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HEADER    INSULIN                                 21-MAY-01   1H59              
TITLE     COMPLEX OF IGFBP-5 WITH IGF-I                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: INSULIN-LIKE GROWTH FACTOR IA;                             
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: RESIDUES 49-118;                                           
COMPND   5 SYNONYM: IGF-I, IGF-IA, SOMATOMEDIN C;                               
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5;              
COMPND   8 CHAIN: B;                                                            
COMPND   9 FRAGMENT: N-TERMINAL IGF BINDING DOMAIN RESIDUE 58-111;              
COMPND  10 SYNONYM: IGFBP-5, IBP-5, IGF-BINDING PROTEIN 5                       
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   7 ORGANISM_COMMON: HUMAN;                                              
SOURCE   8 ORGANISM_TAXID: 9606                                                 
KEYWDS    INSULIN, INSULIN-LIKE GROWTH FACTOR, IGF BINDING PROTEIN              
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    W.ZESLAWSKI,H.G.BEISEL,M.KAMIONKA,W.KALUS,R.A.ENGH,R.HUBER,           
AUTHOR   2 T.A.HOLAK                                                            
REVDAT   2   24-FEB-09 1H59    1       VERSN                                    
REVDAT   1   16-MAY-02 1H59    0                                                
JRNL        AUTH   W.ZESAAWSKI,H.G.BEISEL,M.KAMIONKA,W.KALUS,R.A.ENGH,          
JRNL        AUTH 2 R.HUBER,K.LANG,T.A.HOLAK                                     
JRNL        TITL   THE INTERACTION OF INSULIN-LIKE GROWTH FACTOR-I              
JRNL        TITL 2 WITH THE N-TERMINAL DOMAIN OF IGFBP-5                        
JRNL        REF    EMBO J.                       V.  20  3638 2001              
JRNL        REFN                   ISSN 0261-4189                               
JRNL        PMID   11447105                                                     
JRNL        DOI    10.1093/EMBOJ/20.14.3638                                     
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.1  ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.0                                              
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,             
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : NULL                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.1                            
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 16.2                           
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.0                            
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL                           
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL                           
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 99.3                           
REMARK   3   NUMBER OF REFLECTIONS             : 8023                           
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.218                           
REMARK   3   FREE R VALUE                     : 0.262                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 6                               
REMARK   3   FREE R VALUE TEST SET COUNT      : 501                             
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL                         
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL                         
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL                         
REMARK   3   BIN R VALUE           (WORKING SET) : NULL                         
REMARK   3   BIN FREE R VALUE                    : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL                         
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL                         
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 765                                     
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 44                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL                            
REMARK   3   ESD FROM SIGMAA              (A) : NULL                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.013                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.7                             
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL                            
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : NULL                                      
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : NULL                                                 
REMARK   3   KSOL        : NULL                                                 
REMARK   3   BSOL        : NULL                                                 
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : NULL                                           
REMARK   3  PARAMETER FILE  2  : NULL                                           
REMARK   3  PARAMETER FILE  3  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : NULL                                           
REMARK   3  TOPOLOGY FILE  2   : NULL                                           
REMARK   3  TOPOLOGY FILE  3   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1H59 COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 21-MAY-01.                  
REMARK 100 THE PDBE ID CODE IS EBI-8077.                                        
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : NULL                               
REMARK 200  TEMPERATURE           (KELVIN) : 278.0                              
REMARK 200  PH                             : 5.60                               
REMARK 200  NUMBER OF CRYSTALS USED        : 2                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : N                                  
REMARK 200  RADIATION SOURCE               : ROTATING ANODE                     
REMARK 200  BEAMLINE                       : NULL                               
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU RU200                       
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418                             
REMARK 200  MONOCHROMATOR                  : GRAPHITE                           
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE                        
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH                        
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM                             
REMARK 200  DATA SCALING SOFTWARE          : CCP4 (SCALA)                       
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 8035                               
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.100                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 16.200                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 96.9                               
REMARK 200  DATA REDUNDANCY                : 5.600                              
REMARK 200  R MERGE                    (I) : 0.08200                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.11                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.23                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.9                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.44800                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SIR                          
REMARK 200 SOFTWARE USED: NULL                                                  
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): NULL                                      
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): NULL                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: NULL                                     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 3                           
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X+1/2,-Y,Z+1/2                                         
REMARK 290       3555   -X,Y+1/2,-Z+1/2                                         
REMARK 290       4555   X+1/2,-Y+1/2,-Z                                         
REMARK 290       5555   Z,X,Y                                                   
REMARK 290       6555   Z+1/2,-X+1/2,-Y                                         
REMARK 290       7555   -Z+1/2,-X,Y+1/2                                         
REMARK 290       8555   -Z,X+1/2,-Y+1/2                                         
REMARK 290       9555   Y,Z,X                                                   
REMARK 290      10555   -Y,Z+1/2,-X+1/2                                         
REMARK 290      11555   Y+1/2,-Z+1/2,-X                                         
REMARK 290      12555   -Y+1/2,-Z,X+1/2                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       37.19250            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       37.19250            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       37.19250            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       37.19250            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       37.19250            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       37.19250            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY2   5  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY1   6  0.000000  0.000000  1.000000       37.19250            
REMARK 290   SMTRY2   6 -1.000000  0.000000  0.000000       37.19250            
REMARK 290   SMTRY3   6  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY1   7  0.000000  0.000000 -1.000000       37.19250            
REMARK 290   SMTRY2   7 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   7  0.000000  1.000000  0.000000       37.19250            
REMARK 290   SMTRY1   8  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY2   8  1.000000  0.000000  0.000000       37.19250            
REMARK 290   SMTRY3   8  0.000000 -1.000000  0.000000       37.19250            
REMARK 290   SMTRY1   9  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   9  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY3   9  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY1  10  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY2  10  0.000000  0.000000  1.000000       37.19250            
REMARK 290   SMTRY3  10 -1.000000  0.000000  0.000000       37.19250            
REMARK 290   SMTRY1  11  0.000000  1.000000  0.000000       37.19250            
REMARK 290   SMTRY2  11  0.000000  0.000000 -1.000000       37.19250            
REMARK 290   SMTRY3  11 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY1  12  0.000000 -1.000000  0.000000       37.19250            
REMARK 290   SMTRY2  12  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY3  12  1.000000  0.000000  0.000000       37.19250            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY.  THE REMARK MAY ALSO PROVIDE INFORMATION ON              
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300                                                                      
REMARK 300 DETAILS:TRIMER OF THE HETERODIMERIC COMPLEX OF IGF-                  
REMARK 300 IA AND IGFBP-5                                                       
REMARK 350                                                                      
REMARK 350 GENERATING THE BIOMOLECULE                                           
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE:  1                                                      
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC                  
REMARK 350 SOFTWARE USED: PQS                                                   
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 350   BIOMT2   2  1.000000  0.000000  0.000000       37.19250            
REMARK 350   BIOMT3   2  0.000000 -1.000000  0.000000       37.19250            
REMARK 350   BIOMT1   3  0.000000  1.000000  0.000000      -37.19250            
REMARK 350   BIOMT2   3  0.000000  0.000000 -1.000000       37.19250            
REMARK 350   BIOMT3   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 375                                                                      
REMARK 375 SPECIAL POSITION                                                     
REMARK 375      HOH A2017  LIES ON A SPECIAL POSITION.                          
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLY A     1                                                      
REMARK 465     GLY A    32                                                      
REMARK 465     SER A    33                                                      
REMARK 465     SER A    34                                                      
REMARK 465     SER A    35                                                      
REMARK 465     ARG A    36                                                      
REMARK 465     ARG A    37                                                      
REMARK 465     ALA A    38                                                      
REMARK 465     PRO A    39                                                      
REMARK 465     GLN A    40                                                      
REMARK 465     LYS A    65                                                      
REMARK 465     PRO A    66                                                      
REMARK 465     ALA A    67                                                      
REMARK 465     LYS A    68                                                      
REMARK 465     SER A    69                                                      
REMARK 465     ALA A    70                                                      
REMARK 465     LYS B    84                                                      
REMARK 465     SER B    85                                                      
REMARK 465     TYR B    86                                                      
REMARK 465     ARG B    87                                                      
REMARK 465     GLU B    88                                                      
REMARK 465     GLN B    89                                                      
REMARK 465     VAL B    90                                                      
REMARK 465     LYS B    91                                                      
REMARK 465     ILE B    92                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ARG A  50      -82.36   -114.61                                   
REMARK 500    ASN B  82     -112.73    -27.44                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525                                                                      
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT                    
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST                  
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT                 
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE                       
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;                             
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE                  
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 2GF1   RELATED DB: PDB                                   
REMARK 900  INSULIN-LIKE GROWTH FACTOR (NMR, MINIMUM                            
REMARK 900  AVERAGE STRUCTURE)                                                  
REMARK 900 RELATED ID: 3GF1   RELATED DB: PDB                                   
REMARK 900  INSULIN-LIKE GROWTH FACTOR (NMR, 10                                 
REMARK 900  STRUCTURES)                                                         
DBREF  1H59 A    1    70  UNP    P01343   IGFA_HUMAN      49    118             
DBREF  1H59 B   39    92  UNP    P24593   IBP5_HUMAN      59    112             
SEQADV 1H59 SER B   39  UNP  P24593    CYS    59 CONFLICT                       
SEQRES   1 A   70  GLY PRO GLU THR LEU CYS GLY ALA GLU LEU VAL ASP ALA          
SEQRES   2 A   70  LEU GLN PHE VAL CYS GLY ASP ARG GLY PHE TYR PHE ASN          
SEQRES   3 A   70  LYS PRO THR GLY TYR GLY SER SER SER ARG ARG ALA PRO          
SEQRES   4 A   70  GLN THR GLY ILE VAL ASP GLU CYS CYS PHE ARG SER CYS          
SEQRES   5 A   70  ASP LEU ARG ARG LEU GLU MET TYR CYS ALA PRO LEU LYS          
SEQRES   6 A   70  PRO ALA LYS SER ALA                                          
SEQRES   1 B   54  SER ALA LEU ALA GLU GLY GLN SER CYS GLY VAL TYR THR          
SEQRES   2 B   54  GLU ARG CYS ALA GLN GLY LEU ARG CYS LEU PRO ARG GLN          
SEQRES   3 B   54  ASP GLU GLU LYS PRO LEU HIS ALA LEU LEU HIS GLY ARG          
SEQRES   4 B   54  GLY VAL CYS LEU ASN GLU LYS SER TYR ARG GLU GLN VAL          
SEQRES   5 B   54  LYS ILE                                                      
FORMUL   3  HOH   *44(H2 O1)                                                    
HELIX    1   1 CYS A    6  GLY A   19  1                                  14    
HELIX    2   2 ASP A   20  GLY A   22  5                                   3    
HELIX    3   3 GLY A   42  ARG A   50  1                                   9    
HELIX    4   4 ASP A   53  TYR A   60  1                                   8    
HELIX    5   5 LYS B   68  HIS B   75  1                                   8    
SHEET    1  BA 3 SER B  46  CYS B  47  0                                        
SHEET    2  BA 3 GLY B  78  LEU B  81 -1  O  GLY B  78   N  CYS B  47           
SHEET    3  BA 3 ARG B  59  LEU B  61 -1  O  ARG B  59   N  LEU B  81           
SSBOND   1 CYS A    6    CYS A   48                          1555   1555  2.03  
SSBOND   2 CYS A   18    CYS A   61                          1555   1555  2.03  
SSBOND   3 CYS A   47    CYS A   52                          1555   1555  2.03  
SSBOND   4 CYS B   47    CYS B   60                          1555   1555  2.04  
SSBOND   5 CYS B   54    CYS B   80                          1555   1555  2.03  
CRYST1   74.385   74.385   74.385  90.00  90.00  90.00 P 21 3       12          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.013443  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.013443  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.013443        0.00000                         
ATOM      1  N   PRO A   2      12.286  21.170  20.867  1.00 48.45           N  
ATOM      2  CA  PRO A   2      10.895  21.262  21.370  1.00 47.18           C  
ATOM      3  C   PRO A   2       9.908  20.943  20.252  1.00 44.31           C  
ATOM      4  O   PRO A   2       9.908  21.594  19.208  1.00 46.80           O  
ATOM      5  CB  PRO A   2      10.704  22.686  21.862  1.00 48.41           C  
ATOM      6  CG  PRO A   2      11.649  23.436  20.928  1.00 49.62           C  
ATOM      7  CD  PRO A   2      12.881  22.517  20.805  1.00 49.31           C  
ATOM      8  N   GLU A   3       9.065  19.942  20.475  1.00 40.09           N  
ATOM      9  CA  GLU A   3       8.078  19.540  19.478  1.00 35.47           C  
ATOM     10  C   GLU A   3       7.002  20.607  19.258  1.00 33.04           C  
ATOM     11  O   GLU A   3       6.553  21.252  20.198  1.00 33.26           O  
ATOM     12  CB  GLU A   3       7.425  18.219  19.904  1.00 31.82           C  
ATOM     13  CG  GLU A   3       6.324  17.741  18.977  1.00 30.50           C  
ATOM     14  CD  GLU A   3       5.811  16.350  19.321  1.00 29.25           C  
ATOM     15  OE1 GLU A   3       5.562  16.074  20.512  1.00 29.70           O  
ATOM     16  OE2 GLU A   3       5.640  15.537  18.391  1.00 28.06           O  
ATOM     17  N   THR A   4       6.605  20.796  18.006  1.00 33.52           N  
ATOM     18  CA  THR A   4       5.564  21.761  17.671  1.00 32.64           C  
ATOM     19  C   THR A   4       4.539  21.099  16.756  1.00 32.21           C  
ATOM     20  O   THR A   4       4.854  20.143  16.045  1.00 31.41           O  
ATOM     21  CB  THR A   4       6.133  23.010  16.949  1.00 33.01           C  
ATOM     22  OG1 THR A   4       6.850  22.600  15.781  1.00 34.92           O  
ATOM     23  CG2 THR A   4       7.063  23.795  17.868  1.00 33.39           C  
ATOM     24  N   LEU A   5       3.311  21.607  16.794  1.00 28.70           N  
ATOM     25  CA  LEU A   5       2.225  21.094  15.973  1.00 27.95           C  
ATOM     26  C   LEU A   5       1.479  22.281  15.380  1.00 27.71           C  
ATOM     27  O   LEU A   5       1.089  23.196  16.102  1.00 25.30           O  
ATOM     28  CB  LEU A   5       1.248  20.263  16.811  1.00 30.16           C  
ATOM     29  CG  LEU A   5       1.261  18.739  16.718  1.00 32.01           C  
ATOM     30  CD1 LEU A   5      -0.021  18.204  17.364  1.00 27.14           C  
ATOM     31  CD2 LEU A   5       1.346  18.295  15.262  1.00 28.94           C  
ATOM     32  N   CYS A   6       1.274  22.257  14.068  1.00 27.68           N  
ATOM     33  CA  CYS A   6       0.586  23.344  13.387  1.00 27.97           C  
ATOM     34  C   CYS A   6      -0.467  22.815  12.429  1.00 27.16           C  
ATOM     35  O   CYS A   6      -0.555  21.617  12.189  1.00 25.39           O  
ATOM     36  CB  CYS A   6       1.580  24.177  12.571  1.00 31.40           C  
ATOM     37  SG  CYS A   6       3.038  24.809  13.457  1.00 38.95           S  
ATOM     38  N   GLY A   7      -1.255  23.736  11.887  1.00 26.22           N  
ATOM     39  CA  GLY A   7      -2.279  23.399  10.914  1.00 25.51           C  
ATOM     40  C   GLY A   7      -3.307  22.330  11.229  1.00 25.84           C  
ATOM     41  O   GLY A   7      -3.814  22.213  12.351  1.00 24.26           O  
ATOM     42  N   ALA A   8      -3.633  21.559  10.199  1.00 22.75           N  
ATOM     43  CA  ALA A   8      -4.622  20.495  10.301  1.00 23.80           C  
ATOM     44  C   ALA A   8      -4.242  19.484  11.371  1.00 22.59           C  
ATOM     45  O   ALA A   8      -5.102  18.969  12.073  1.00 23.77           O  
ATOM     46  CB  ALA A   8      -4.783  19.804   8.946  1.00 23.28           C  
ATOM     47  N   GLU A   9      -2.950  19.205  11.511  1.00 23.09           N  
ATOM     48  CA  GLU A   9      -2.528  18.244  12.522  1.00 24.67           C  
ATOM     49  C   GLU A   9      -2.799  18.730  13.935  1.00 21.39           C  
ATOM     50  O   GLU A   9      -3.115  17.934  14.812  1.00 21.62           O  
ATOM     51  CB  GLU A   9      -1.047  17.911  12.370  1.00 26.80           C  
ATOM     52  CG  GLU A   9      -0.741  17.101  11.132  1.00 32.24           C  
ATOM     53  CD  GLU A   9       0.698  16.651  11.096  1.00 36.38           C  
ATOM     54  OE1 GLU A   9       1.588  17.526  11.148  1.00 39.56           O  
ATOM     55  OE2 GLU A   9       0.936  15.427  11.022  1.00 37.49           O  
ATOM     56  N   LEU A  10      -2.660  20.032  14.163  1.00 20.36           N  
ATOM     57  CA  LEU A  10      -2.915  20.588  15.484  1.00 19.60           C  
ATOM     58  C   LEU A  10      -4.411  20.461  15.818  1.00 18.65           C  
ATOM     59  O   LEU A  10      -4.793  20.141  16.945  1.00 16.88           O  
ATOM     60  CB  LEU A  10      -2.488  22.061  15.530  1.00 20.83           C  
ATOM     61  CG  LEU A  10      -2.900  22.790  16.813  1.00 23.06           C  
ATOM     62  CD1 LEU A  10      -2.279  22.087  18.012  1.00 22.52           C  
ATOM     63  CD2 LEU A  10      -2.466  24.252  16.753  1.00 24.50           C  
ATOM     64  N   VAL A  11      -5.253  20.732  14.830  1.00 15.88           N  
ATOM     65  CA  VAL A  11      -6.695  20.633  15.013  1.00 18.59           C  
ATOM     66  C   VAL A  11      -7.097  19.177  15.250  1.00 18.86           C  
ATOM     67  O   VAL A  11      -7.914  18.891  16.116  1.00 19.03           O  
ATOM     68  CB  VAL A  11      -7.455  21.193  13.786  1.00 21.42           C  
ATOM     69  CG1 VAL A  11      -8.955  20.957  13.935  1.00 21.23           C  
ATOM     70  CG2 VAL A  11      -7.185  22.691  13.659  1.00 23.65           C  
ATOM     71  N   ASP A  12      -6.520  18.253  14.489  1.00 19.12           N  
ATOM     72  CA  ASP A  12      -6.853  16.845  14.679  1.00 17.94           C  
ATOM     73  C   ASP A  12      -6.449  16.374  16.074  1.00 17.94           C  
ATOM     74  O   ASP A  12      -7.192  15.636  16.715  1.00 17.22           O  
ATOM     75  CB  ASP A  12      -6.173  15.977  13.615  1.00 18.04           C  
ATOM     76  CG  ASP A  12      -6.792  16.155  12.239  1.00 18.18           C  
ATOM     77  OD1 ASP A  12      -7.888  16.747  12.148  1.00 17.41           O  
ATOM     78  OD2 ASP A  12      -6.190  15.696  11.250  1.00 17.12           O  
ATOM     79  N   ALA A  13      -5.277  16.804  16.538  1.00 17.64           N  
ATOM     80  CA  ALA A  13      -4.796  16.430  17.870  1.00 19.37           C  
ATOM     81  C   ALA A  13      -5.751  16.943  18.952  1.00 19.44           C  
ATOM     82  O   ALA A  13      -6.028  16.242  19.925  1.00 22.14           O  
ATOM     83  CB  ALA A  13      -3.371  16.986  18.101  1.00 13.96           C  
ATOM     84  N   LEU A  14      -6.245  18.168  18.783  1.00 21.01           N  
ATOM     85  CA  LEU A  14      -7.188  18.760  19.735  1.00 22.46           C  
ATOM     86  C   LEU A  14      -8.498  17.976  19.777  1.00 21.46           C  
ATOM     87  O   LEU A  14      -9.054  17.715  20.848  1.00 22.17           O  
ATOM     88  CB  LEU A  14      -7.482  20.216  19.359  1.00 22.01           C  
ATOM     89  CG  LEU A  14      -6.434  21.234  19.809  1.00 24.59           C  
ATOM     90  CD1 LEU A  14      -6.611  22.540  19.059  1.00 26.66           C  
ATOM     91  CD2 LEU A  14      -6.554  21.439  21.309  1.00 24.62           C  
ATOM     92  N   GLN A  15      -8.993  17.615  18.600  1.00 21.30           N  
ATOM     93  CA  GLN A  15     -10.224  16.845  18.487  1.00 22.52           C  
ATOM     94  C   GLN A  15     -10.040  15.491  19.174  1.00 22.02           C  
ATOM     95  O   GLN A  15     -10.938  15.003  19.860  1.00 22.22           O  
ATOM     96  CB  GLN A  15     -10.577  16.631  17.010  1.00 21.07           C  
ATOM     97  CG  GLN A  15     -11.745  15.682  16.800  1.00 27.80           C  
ATOM     98  CD  GLN A  15     -13.071  16.277  17.247  1.00 29.64           C  
ATOM     99  OE1 GLN A  15     -13.943  15.568  17.747  1.00 35.24           O  
ATOM    100  NE2 GLN A  15     -13.231  17.579  17.057  1.00 28.27           N  
ATOM    101  N   PHE A  16      -8.866  14.893  18.997  1.00 21.16           N  
ATOM    102  CA  PHE A  16      -8.584  13.596  19.606  1.00 24.00           C  
ATOM    103  C   PHE A  16      -8.499  13.703  21.133  1.00 24.10           C  
ATOM    104  O   PHE A  16      -9.121  12.927  21.854  1.00 23.16           O  
ATOM    105  CB  PHE A  16      -7.271  13.019  19.056  1.00 23.82           C  
ATOM    106  CG  PHE A  16      -6.952  11.640  19.578  1.00 29.07           C  
ATOM    107  CD1 PHE A  16      -7.795  10.566  19.303  1.00 31.09           C  
ATOM    108  CD2 PHE A  16      -5.821  11.419  20.357  1.00 31.17           C  
ATOM    109  CE1 PHE A  16      -7.518   9.289  19.796  1.00 32.48           C  
ATOM    110  CE2 PHE A  16      -5.532  10.143  20.857  1.00 34.53           C  
ATOM    111  CZ  PHE A  16      -6.382   9.078  20.576  1.00 32.86           C  
ATOM    112  N   VAL A  17      -7.741  14.677  21.623  1.00 22.26           N  
ATOM    113  CA  VAL A  17      -7.578  14.856  23.062  1.00 24.25           C  
ATOM    114  C   VAL A  17      -8.859  15.289  23.775  1.00 25.86           C  
ATOM    115  O   VAL A  17      -9.221  14.726  24.803  1.00 26.11           O  
ATOM    116  CB  VAL A  17      -6.457  15.886  23.360  1.00 25.26           C  
ATOM    117  CG1 VAL A  17      -6.397  16.202  24.848  1.00 24.79           C  
ATOM    118  CG2 VAL A  17      -5.126  15.336  22.893  1.00 22.56           C  
ATOM    119  N   CYS A  18      -9.551  16.275  23.215  1.00 26.25           N  
ATOM    120  CA  CYS A  18     -10.772  16.806  23.819  1.00 27.65           C  
ATOM    121  C   CYS A  18     -12.067  16.036  23.553  1.00 29.15           C  
ATOM    122  O   CYS A  18     -12.993  16.092  24.358  1.00 31.90           O  
ATOM    123  CB  CYS A  18     -10.949  18.263  23.392  1.00 22.29           C  
ATOM    124  SG  CYS A  18      -9.517  19.306  23.795  1.00 21.36           S  
ATOM    125  N   GLY A  19     -12.144  15.337  22.426  1.00 31.46           N  
ATOM    126  CA  GLY A  19     -13.340  14.568  22.121  1.00 31.99           C  
ATOM    127  C   GLY A  19     -14.626  15.372  22.043  1.00 34.26           C  
ATOM    128  O   GLY A  19     -14.649  16.479  21.504  1.00 35.27           O  
ATOM    129  N   ASP A  20     -15.700  14.816  22.594  1.00 34.61           N  
ATOM    130  CA  ASP A  20     -17.003  15.470  22.575  1.00 37.53           C  
ATOM    131  C   ASP A  20     -17.090  16.743  23.416  1.00 35.72           C  
ATOM    132  O   ASP A  20     -18.071  17.475  23.329  1.00 37.26           O  
ATOM    133  CB  ASP A  20     -18.094  14.486  23.016  1.00 40.28           C  
ATOM    134  CG  ASP A  20     -17.768  13.810  24.322  1.00 44.00           C  
ATOM    135  OD1 ASP A  20     -17.483  14.523  25.305  1.00 47.54           O  
ATOM    136  OD2 ASP A  20     -17.797  12.563  24.369  1.00 50.02           O  
ATOM    137  N   ARG A  21     -16.073  17.016  24.225  1.00 35.25           N  
ATOM    138  CA  ARG A  21     -16.083  18.228  25.041  1.00 32.99           C  
ATOM    139  C   ARG A  21     -15.962  19.473  24.166  1.00 31.94           C  
ATOM    140  O   ARG A  21     -16.540  20.513  24.465  1.00 32.47           O  
ATOM    141  CB  ARG A  21     -14.920  18.218  26.028  1.00 33.07           C  
ATOM    142  CG  ARG A  21     -14.955  17.084  27.027  1.00 36.04           C  
ATOM    143  CD  ARG A  21     -13.650  17.027  27.788  1.00 38.67           C  
ATOM    144  NE  ARG A  21     -13.361  18.293  28.449  1.00 40.34           N  
ATOM    145  CZ  ARG A  21     -12.237  18.547  29.109  1.00 41.42           C  
ATOM    146  NH1 ARG A  21     -11.296  17.618  29.194  1.00 39.64           N  
ATOM    147  NH2 ARG A  21     -12.057  19.728  29.688  1.00 42.26           N  
ATOM    148  N   GLY A  22     -15.214  19.365  23.075  1.00 29.01           N  
ATOM    149  CA  GLY A  22     -15.024  20.521  22.221  1.00 26.06           C  
ATOM    150  C   GLY A  22     -13.815  21.261  22.757  1.00 24.26           C  
ATOM    151  O   GLY A  22     -13.289  20.890  23.802  1.00 22.46           O  
ATOM    152  N   PHE A  23     -13.373  22.306  22.066  1.00 22.86           N  
ATOM    153  CA  PHE A  23     -12.198  23.045  22.512  1.00 22.17           C  
ATOM    154  C   PHE A  23     -12.181  24.489  22.024  1.00 21.88           C  
ATOM    155  O   PHE A  23     -12.973  24.877  21.162  1.00 23.17           O  
ATOM    156  CB  PHE A  23     -10.933  22.312  22.039  1.00 20.23           C  
ATOM    157  CG  PHE A  23     -10.925  22.004  20.560  1.00 21.99           C  
ATOM    158  CD1 PHE A  23     -10.457  22.938  19.642  1.00 22.24           C  
ATOM    159  CD2 PHE A  23     -11.414  20.787  20.086  1.00 23.68           C  
ATOM    160  CE1 PHE A  23     -10.474  22.670  18.270  1.00 25.86           C  
ATOM    161  CE2 PHE A  23     -11.439  20.506  18.713  1.00 25.11           C  
ATOM    162  CZ  PHE A  23     -10.968  21.449  17.805  1.00 25.09           C  
ATOM    163  N   TYR A  24     -11.274  25.279  22.587  1.00 21.43           N  
ATOM    164  CA  TYR A  24     -11.134  26.683  22.215  1.00 22.21           C  
ATOM    165  C   TYR A  24      -9.784  26.938  21.576  1.00 23.50           C  
ATOM    166  O   TYR A  24      -8.853  26.141  21.727  1.00 23.43           O  
ATOM    167  CB  TYR A  24     -11.273  27.587  23.439  1.00 22.91           C  
ATOM    168  CG  TYR A  24     -12.633  27.540  24.077  1.00 23.87           C  
ATOM    169  CD1 TYR A  24     -13.779  27.855  23.345  1.00 23.25           C  
ATOM    170  CD2 TYR A  24     -12.781  27.175  25.411  1.00 25.69           C  
ATOM    171  CE1 TYR A  24     -15.036  27.804  23.928  1.00 23.74           C  
ATOM    172  CE2 TYR A  24     -14.034  27.125  26.003  1.00 25.28           C  
ATOM    173  CZ  TYR A  24     -15.153  27.437  25.260  1.00 26.80           C  
ATOM    174  OH  TYR A  24     -16.389  27.374  25.853  1.00 30.71           O  
ATOM    175  N   PHE A  25      -9.682  28.064  20.875  1.00 22.72           N  
ATOM    176  CA  PHE A  25      -8.448  28.451  20.208  1.00 25.06           C  
ATOM    177  C   PHE A  25      -7.732  29.657  20.804  1.00 26.11           C  
ATOM    178  O   PHE A  25      -6.514  29.635  20.992  1.00 26.19           O  
ATOM    179  CB  PHE A  25      -8.706  28.776  18.731  1.00 24.67           C  
ATOM    180  CG  PHE A  25      -8.965  27.582  17.878  1.00 27.79           C  
ATOM    181  CD1 PHE A  25     -10.263  27.237  17.517  1.00 27.21           C  
ATOM    182  CD2 PHE A  25      -7.909  26.803  17.417  1.00 28.61           C  
ATOM    183  CE1 PHE A  25     -10.506  26.131  16.705  1.00 30.80           C  
ATOM    184  CE2 PHE A  25      -8.143  25.692  16.604  1.00 30.69           C  
ATOM    185  CZ  PHE A  25      -9.445  25.358  16.248  1.00 28.62           C  
ATOM    186  N   ASN A  26      -8.482  30.714  21.095  1.00 27.47           N  
ATOM    187  CA  ASN A  26      -7.865  31.948  21.574  1.00 29.42           C  
ATOM    188  C   ASN A  26      -7.345  31.989  23.000  1.00 29.47           C  
ATOM    189  O   ASN A  26      -6.367  32.680  23.280  1.00 29.14           O  
ATOM    190  CB  ASN A  26      -8.809  33.129  21.342  1.00 28.22           C  
ATOM    191  CG  ASN A  26      -8.057  34.427  21.126  1.00 31.48           C  
ATOM    192  OD1 ASN A  26      -7.194  34.509  20.254  1.00 34.77           O  
ATOM    193  ND2 ASN A  26      -8.372  35.441  21.914  1.00 31.59           N  
ATOM    194  N   LYS A  27      -7.995  31.263  23.901  1.00 29.57           N  
ATOM    195  CA  LYS A  27      -7.569  31.244  25.293  1.00 30.66           C  
ATOM    196  C   LYS A  27      -7.821  29.864  25.867  1.00 31.08           C  
ATOM    197  O   LYS A  27      -8.707  29.148  25.403  1.00 30.45           O  
ATOM    198  CB  LYS A  27      -8.362  32.264  26.118  1.00 30.77           C  
ATOM    199  CG  LYS A  27      -8.294  33.694  25.627  1.00 34.21           C  
ATOM    200  CD  LYS A  27      -6.919  34.297  25.856  1.00 37.48           C  
ATOM    201  CE  LYS A  27      -6.920  35.784  25.530  1.00 40.53           C  
ATOM    202  NZ  LYS A  27      -5.582  36.399  25.766  1.00 44.14           N  
ATOM    203  N   PRO A  28      -7.032  29.464  26.875  1.00 31.82           N  
ATOM    204  CA  PRO A  28      -7.215  28.152  27.496  1.00 33.47           C  
ATOM    205  C   PRO A  28      -8.391  28.272  28.459  1.00 35.58           C  
ATOM    206  O   PRO A  28      -8.724  29.377  28.900  1.00 32.43           O  
ATOM    207  CB  PRO A  28      -5.895  27.932  28.225  1.00 34.86           C  
ATOM    208  CG  PRO A  28      -5.534  29.319  28.659  1.00 34.31           C  
ATOM    209  CD  PRO A  28      -5.841  30.142  27.421  1.00 32.67           C  
ATOM    210  N   THR A  29      -9.025  27.150  28.774  1.00 37.76           N  
ATOM    211  CA  THR A  29     -10.154  27.165  29.695  1.00 41.89           C  
ATOM    212  C   THR A  29      -9.631  27.378  31.110  1.00 45.51           C  
ATOM    213  O   THR A  29      -8.550  26.903  31.456  1.00 44.18           O  
ATOM    214  CB  THR A  29     -10.940  25.836  29.640  1.00 41.67           C  
ATOM    215  OG1 THR A  29     -11.557  25.697  28.353  1.00 43.11           O  
ATOM    216  CG2 THR A  29     -12.019  25.805  30.717  1.00 42.37           C  
ATOM    217  N   GLY A  30     -10.390  28.112  31.916  1.00 50.36           N  
ATOM    218  CA  GLY A  30      -9.985  28.354  33.288  1.00 56.95           C  
ATOM    219  C   GLY A  30      -8.974  29.468  33.469  1.00 61.71           C  
ATOM    220  O   GLY A  30      -9.261  30.628  33.172  1.00 63.19           O  
ATOM    221  N   TYR A  31      -7.787  29.107  33.955  1.00 65.17           N  
ATOM    222  CA  TYR A  31      -6.715  30.067  34.209  1.00 68.15           C  
ATOM    223  C   TYR A  31      -7.058  30.842  35.479  1.00 68.59           C  
ATOM    224  O   TYR A  31      -7.492  32.010  35.373  1.00 69.00           O  
ATOM    225  CB  TYR A  31      -6.541  31.020  33.015  1.00 70.95           C  
ATOM    226  CG  TYR A  31      -5.399  32.012  33.154  1.00 73.49           C  
ATOM    227  CD1 TYR A  31      -5.486  33.094  34.033  1.00 74.34           C  
ATOM    228  CD2 TYR A  31      -4.229  31.868  32.406  1.00 74.79           C  
ATOM    229  CE1 TYR A  31      -4.445  34.004  34.167  1.00 76.14           C  
ATOM    230  CE2 TYR A  31      -3.177  32.778  32.533  1.00 76.14           C  
ATOM    231  CZ  TYR A  31      -3.294  33.842  33.416  1.00 76.89           C  
ATOM    232  OH  TYR A  31      -2.264  34.743  33.556  1.00 77.25           O  
ATOM    233  OXT TYR A  31      -6.913  30.253  36.573  1.00 68.68           O  
ATOM    234  N   THR A  41      -2.348  32.688  26.380  1.00 41.52           N  
ATOM    235  CA  THR A  41      -2.354  33.032  24.928  1.00 40.17           C  
ATOM    236  C   THR A  41      -3.105  31.956  24.138  1.00 36.92           C  
ATOM    237  O   THR A  41      -3.705  31.060  24.730  1.00 36.68           O  
ATOM    238  CB  THR A  41      -0.918  33.149  24.393  1.00 42.36           C  
ATOM    239  OG1 THR A  41      -0.923  33.851  23.141  1.00 46.28           O  
ATOM    240  CG2 THR A  41      -0.325  31.766  24.185  1.00 44.57           C  
ATOM    241  N   GLY A  42      -3.064  32.049  22.809  1.00 33.32           N  
ATOM    242  CA  GLY A  42      -3.763  31.092  21.963  1.00 30.89           C  
ATOM    243  C   GLY A  42      -2.997  29.810  21.687  1.00 29.22           C  
ATOM    244  O   GLY A  42      -1.768  29.789  21.730  1.00 27.67           O  
ATOM    245  N   ILE A  43      -3.726  28.738  21.383  1.00 27.59           N  
ATOM    246  CA  ILE A  43      -3.106  27.441  21.115  1.00 26.54           C  
ATOM    247  C   ILE A  43      -2.186  27.427  19.878  1.00 26.00           C  
ATOM    248  O   ILE A  43      -1.163  26.742  19.875  1.00 23.28           O  
ATOM    249  CB  ILE A  43      -4.184  26.327  20.976  1.00 26.50           C  
ATOM    250  CG1 ILE A  43      -3.513  24.950  20.910  1.00 28.05           C  
ATOM    251  CG2 ILE A  43      -5.039  26.562  19.734  1.00 25.25           C  
ATOM    252  CD1 ILE A  43      -2.830  24.535  22.192  1.00 29.33           C  
ATOM    253  N   VAL A  44      -2.544  28.166  18.831  1.00 27.62           N  
ATOM    254  CA  VAL A  44      -1.704  28.221  17.628  1.00 31.20           C  
ATOM    255  C   VAL A  44      -0.354  28.848  17.968  1.00 33.88           C  
ATOM    256  O   VAL A  44       0.694  28.350  17.550  1.00 33.44           O  
ATOM    257  CB  VAL A  44      -2.353  29.056  16.502  1.00 32.97           C  
ATOM    258  CG1 VAL A  44      -1.364  29.237  15.353  1.00 33.20           C  
ATOM    259  CG2 VAL A  44      -3.614  28.368  16.001  1.00 33.05           C  
ATOM    260  N   ASP A  45      -0.383  29.944  18.724  1.00 35.62           N  
ATOM    261  CA  ASP A  45       0.844  30.623  19.132  1.00 36.95           C  
ATOM    262  C   ASP A  45       1.719  29.668  19.931  1.00 37.42           C  
ATOM    263  O   ASP A  45       2.888  29.467  19.608  1.00 40.61           O  
ATOM    264  CB  ASP A  45       0.524  31.847  19.996  1.00 38.58           C  
ATOM    265  CG  ASP A  45       0.486  33.135  19.198  1.00 39.81           C  
ATOM    266  OD1 ASP A  45      -0.356  34.000  19.516  1.00 42.11           O  
ATOM    267  OD2 ASP A  45       1.300  33.291  18.265  1.00 38.39           O  
ATOM    268  N   GLU A  46       1.150  29.082  20.980  1.00 35.14           N  
ATOM    269  CA  GLU A  46       1.903  28.154  21.810  1.00 34.98           C  
ATOM    270  C   GLU A  46       2.383  26.937  21.027  1.00 33.34           C  
ATOM    271  O   GLU A  46       3.577  26.795  20.765  1.00 33.89           O  
ATOM    272  CB  GLU A  46       1.062  27.683  22.999  1.00 35.29           C  
ATOM    273  CG  GLU A  46       0.816  28.736  24.070  1.00 41.36           C  
ATOM    274  CD  GLU A  46       2.103  29.232  24.714  1.00 44.18           C  
ATOM    275  OE1 GLU A  46       2.938  28.388  25.107  1.00 44.06           O  
ATOM    276  OE2 GLU A  46       2.277  30.463  24.833  1.00 44.52           O  
ATOM    277  N   CYS A  47       1.444  26.077  20.637  1.00 29.37           N  
ATOM    278  CA  CYS A  47       1.769  24.844  19.923  1.00 29.96           C  
ATOM    279  C   CYS A  47       2.496  24.937  18.595  1.00 29.21           C  
ATOM    280  O   CYS A  47       3.383  24.132  18.320  1.00 30.38           O  
ATOM    281  CB  CYS A  47       0.504  23.986  19.756  1.00 26.58           C  
ATOM    282  SG  CYS A  47       0.250  22.978  21.239  1.00 26.80           S  
ATOM    283  N   CYS A  48       2.153  25.919  17.777  1.00 28.58           N  
ATOM    284  CA  CYS A  48       2.792  26.029  16.479  1.00 30.29           C  
ATOM    285  C   CYS A  48       4.138  26.760  16.422  1.00 32.48           C  
ATOM    286  O   CYS A  48       5.013  26.394  15.629  1.00 31.64           O  
ATOM    287  CB  CYS A  48       1.825  26.666  15.482  1.00 32.91           C  
ATOM    288  SG  CYS A  48       2.559  26.749  13.832  1.00 41.22           S  
ATOM    289  N   PHE A  49       4.318  27.775  17.261  1.00 32.39           N  
ATOM    290  CA  PHE A  49       5.559  28.545  17.247  1.00 33.94           C  
ATOM    291  C   PHE A  49       6.477  28.382  18.452  1.00 34.62           C  
ATOM    292  O   PHE A  49       7.656  28.724  18.376  1.00 36.79           O  
ATOM    293  CB  PHE A  49       5.232  30.028  17.057  1.00 32.89           C  
ATOM    294  CG  PHE A  49       4.520  30.322  15.771  1.00 30.98           C  
ATOM    295  CD1 PHE A  49       5.168  30.155  14.552  1.00 30.72           C  
ATOM    296  CD2 PHE A  49       3.194  30.737  15.774  1.00 29.66           C  
ATOM    297  CE1 PHE A  49       4.504  30.397  13.353  1.00 31.20           C  
ATOM    298  CE2 PHE A  49       2.523  30.981  14.584  1.00 29.98           C  
ATOM    299  CZ  PHE A  49       3.178  30.810  13.371  1.00 31.19           C  
ATOM    300  N   ARG A  50       5.956  27.859  19.558  1.00 35.31           N  
ATOM    301  CA  ARG A  50       6.765  27.687  20.759  1.00 37.16           C  
ATOM    302  C   ARG A  50       6.980  26.223  21.149  1.00 37.35           C  
ATOM    303  O   ARG A  50       8.011  25.632  20.832  1.00 37.72           O  
ATOM    304  CB  ARG A  50       6.127  28.456  21.922  1.00 39.61           C  
ATOM    305  CG  ARG A  50       6.136  29.980  21.735  1.00 45.48           C  
ATOM    306  CD  ARG A  50       5.256  30.688  22.769  1.00 49.13           C  
ATOM    307  NE  ARG A  50       5.220  32.139  22.566  1.00 54.47           N  
ATOM    308  CZ  ARG A  50       4.361  32.962  23.171  1.00 57.80           C  
ATOM    309  NH1 ARG A  50       3.455  32.485  24.018  1.00 58.23           N  
ATOM    310  NH2 ARG A  50       4.410  34.271  22.943  1.00 58.43           N  
ATOM    311  N   SER A  51       6.009  25.636  21.836  1.00 36.82           N  
ATOM    312  CA  SER A  51       6.123  24.245  22.259  1.00 36.64           C  
ATOM    313  C   SER A  51       4.749  23.614  22.450  1.00 34.49           C  
ATOM    314  O   SER A  51       3.830  24.255  22.959  1.00 35.64           O  
ATOM    315  CB  SER A  51       6.913  24.160  23.569  1.00 36.90           C  
ATOM    316  OG  SER A  51       6.843  22.858  24.116  1.00 42.09           O  
ATOM    317  N   CYS A  52       4.620  22.353  22.047  1.00 31.83           N  
ATOM    318  CA  CYS A  52       3.355  21.636  22.171  1.00 27.84           C  
ATOM    319  C   CYS A  52       3.572  20.302  22.862  1.00 27.84           C  
ATOM    320  O   CYS A  52       4.584  19.641  22.645  1.00 29.73           O  
ATOM    321  CB  CYS A  52       2.765  21.374  20.786  1.00 26.29           C  
ATOM    322  SG  CYS A  52       0.950  21.153  20.677  1.00 25.58           S  
ATOM    323  N   ASP A  53       2.622  19.926  23.706  1.00 28.33           N  
ATOM    324  CA  ASP A  53       2.649  18.649  24.398  1.00 30.31           C  
ATOM    325  C   ASP A  53       1.216  18.346  24.795  1.00 30.38           C  
ATOM    326  O   ASP A  53       0.338  19.207  24.664  1.00 29.48           O  
ATOM    327  CB  ASP A  53       3.561  18.679  25.634  1.00 33.16           C  
ATOM    328  CG  ASP A  53       3.229  19.806  26.596  1.00 35.20           C  
ATOM    329  OD1 ASP A  53       2.036  20.048  26.866  1.00 34.50           O  
ATOM    330  OD2 ASP A  53       4.179  20.440  27.100  1.00 39.85           O  
ATOM    331  N   LEU A  54       0.974  17.129  25.266  1.00 29.20           N  
ATOM    332  CA  LEU A  54      -0.368  16.725  25.658  1.00 31.11           C  
ATOM    333  C   LEU A  54      -1.009  17.589  26.734  1.00 30.74           C  
ATOM    334  O   LEU A  54      -2.207  17.870  26.667  1.00 27.74           O  
ATOM    335  CB  LEU A  54      -0.374  15.261  26.110  1.00 31.37           C  
ATOM    336  CG  LEU A  54      -0.354  14.214  24.991  1.00 34.52           C  
ATOM    337  CD1 LEU A  54      -0.302  12.822  25.591  1.00 36.09           C  
ATOM    338  CD2 LEU A  54      -1.603  14.361  24.123  1.00 35.95           C  
ATOM    339  N   ARG A  55      -0.227  18.012  27.725  1.00 31.56           N  
ATOM    340  CA  ARG A  55      -0.782  18.830  28.800  1.00 34.34           C  
ATOM    341  C   ARG A  55      -1.271  20.180  28.282  1.00 32.74           C  
ATOM    342  O   ARG A  55      -2.300  20.682  28.726  1.00 32.45           O  
ATOM    343  CB  ARG A  55       0.251  19.043  29.911  1.00 38.80           C  
ATOM    344  CG  ARG A  55      -0.257  19.915  31.051  1.00 47.66           C  
ATOM    345  CD  ARG A  55       0.785  20.080  32.153  1.00 55.42           C  
ATOM    346  NE  ARG A  55       0.337  21.016  33.183  1.00 61.23           N  
ATOM    347  CZ  ARG A  55       1.059  21.368  34.243  1.00 65.09           C  
ATOM    348  NH1 ARG A  55       2.273  20.862  34.423  1.00 66.31           N  
ATOM    349  NH2 ARG A  55       0.571  22.237  35.120  1.00 66.42           N  
ATOM    350  N   ARG A  56      -0.535  20.757  27.336  1.00 31.40           N  
ATOM    351  CA  ARG A  56      -0.908  22.041  26.760  1.00 33.43           C  
ATOM    352  C   ARG A  56      -2.250  21.930  26.026  1.00 31.70           C  
ATOM    353  O   ARG A  56      -3.121  22.789  26.171  1.00 30.50           O  
ATOM    354  CB  ARG A  56       0.174  22.509  25.786  1.00 36.65           C  
ATOM    355  CG  ARG A  56      -0.072  23.894  25.210  1.00 44.36           C  
ATOM    356  CD  ARG A  56       0.139  24.966  26.264  1.00 50.86           C  
ATOM    357  NE  ARG A  56       1.538  25.052  26.675  1.00 53.58           N  
ATOM    358  CZ  ARG A  56       1.985  25.846  27.641  1.00 56.11           C  
ATOM    359  NH1 ARG A  56       1.141  26.627  28.304  1.00 56.49           N  
ATOM    360  NH2 ARG A  56       3.277  25.865  27.942  1.00 57.01           N  
ATOM    361  N   LEU A  57      -2.408  20.859  25.250  1.00 30.08           N  
ATOM    362  CA  LEU A  57      -3.631  20.619  24.485  1.00 28.56           C  
ATOM    363  C   LEU A  57      -4.873  20.511  25.366  1.00 28.56           C  
ATOM    364  O   LEU A  57      -5.903  21.120  25.077  1.00 26.60           O  
ATOM    365  CB  LEU A  57      -3.484  19.337  23.643  1.00 24.71           C  
ATOM    366  CG  LEU A  57      -2.498  19.427  22.467  1.00 25.16           C  
ATOM    367  CD1 LEU A  57      -2.266  18.052  21.855  1.00 25.45           C  
ATOM    368  CD2 LEU A  57      -3.045  20.381  21.417  1.00 25.04           C  
ATOM    369  N   GLU A  58      -4.771  19.740  26.444  1.00 29.27           N  
ATOM    370  CA  GLU A  58      -5.899  19.546  27.349  1.00 29.45           C  
ATOM    371  C   GLU A  58      -6.379  20.838  28.003  1.00 26.98           C  
ATOM    372  O   GLU A  58      -7.548  20.960  28.356  1.00 26.79           O  
ATOM    373  CB  GLU A  58      -5.539  18.517  28.426  1.00 32.63           C  
ATOM    374  CG  GLU A  58      -5.251  17.142  27.858  1.00 41.62           C  
ATOM    375  CD  GLU A  58      -5.007  16.101  28.931  1.00 46.45           C  
ATOM    376  OE1 GLU A  58      -5.923  15.868  29.748  1.00 47.01           O  
ATOM    377  OE2 GLU A  58      -3.901  15.518  28.954  1.00 47.37           O  
ATOM    378  N   MET A  59      -5.485  21.805  28.156  1.00 25.43           N  
ATOM    379  CA  MET A  59      -5.857  23.079  28.760  1.00 27.07           C  
ATOM    380  C   MET A  59      -6.883  23.827  27.907  1.00 26.07           C  
ATOM    381  O   MET A  59      -7.644  24.648  28.421  1.00 26.94           O  
ATOM    382  CB  MET A  59      -4.622  23.965  28.932  1.00 28.76           C  
ATOM    383  CG  MET A  59      -3.616  23.475  29.953  1.00 33.93           C  
ATOM    384  SD  MET A  59      -2.160  24.548  29.943  1.00 42.31           S  
ATOM    385  CE  MET A  59      -2.861  26.092  30.568  1.00 40.03           C  
ATOM    386  N   TYR A  60      -6.904  23.546  26.607  1.00 23.71           N  
ATOM    387  CA  TYR A  60      -7.828  24.228  25.707  1.00 24.20           C  
ATOM    388  C   TYR A  60      -9.145  23.507  25.468  1.00 24.59           C  
ATOM    389  O   TYR A  60     -10.004  24.015  24.750  1.00 23.53           O  
ATOM    390  CB  TYR A  60      -7.141  24.536  24.367  1.00 22.53           C  
ATOM    391  CG  TYR A  60      -6.054  25.587  24.496  1.00 23.27           C  
ATOM    392  CD1 TYR A  60      -4.794  25.257  25.000  1.00 23.79           C  
ATOM    393  CD2 TYR A  60      -6.301  26.923  24.163  1.00 24.44           C  
ATOM    394  CE1 TYR A  60      -3.811  26.225  25.170  1.00 25.75           C  
ATOM    395  CE2 TYR A  60      -5.323  27.903  24.336  1.00 24.69           C  
ATOM    396  CZ  TYR A  60      -4.080  27.545  24.839  1.00 26.37           C  
ATOM    397  OH  TYR A  60      -3.112  28.503  25.020  1.00 29.55           O  
ATOM    398  N   CYS A  61      -9.314  22.327  26.064  1.00 25.69           N  
ATOM    399  CA  CYS A  61     -10.568  21.598  25.912  1.00 25.12           C  
ATOM    400  C   CYS A  61     -11.642  22.398  26.645  1.00 28.22           C  
ATOM    401  O   CYS A  61     -11.346  23.095  27.609  1.00 26.64           O  
ATOM    402  CB  CYS A  61     -10.480  20.197  26.538  1.00 23.04           C  
ATOM    403  SG  CYS A  61      -9.281  19.035  25.795  1.00 24.30           S  
ATOM    404  N   ALA A  62     -12.885  22.305  26.188  1.00 31.44           N  
ATOM    405  CA  ALA A  62     -13.976  23.021  26.840  1.00 35.50           C  
ATOM    406  C   ALA A  62     -14.387  22.270  28.114  1.00 39.58           C  
ATOM    407  O   ALA A  62     -14.056  21.095  28.287  1.00 38.59           O  
ATOM    408  CB  ALA A  62     -15.165  23.149  25.889  1.00 34.68           C  
ATOM    409  N   PRO A  63     -15.105  22.946  29.029  1.00 43.28           N  
ATOM    410  CA  PRO A  63     -15.559  22.347  30.292  1.00 45.95           C  
ATOM    411  C   PRO A  63     -16.687  21.319  30.182  1.00 48.67           C  
ATOM    412  O   PRO A  63     -17.376  21.235  29.166  1.00 48.01           O  
ATOM    413  CB  PRO A  63     -16.002  23.558  31.116  1.00 46.29           C  
ATOM    414  CG  PRO A  63     -15.224  24.694  30.529  1.00 45.50           C  
ATOM    415  CD  PRO A  63     -15.305  24.404  29.056  1.00 43.94           C  
ATOM    416  N   LEU A  64     -16.855  20.568  31.272  1.00 52.88           N  
ATOM    417  CA  LEU A  64     -17.870  19.528  31.463  1.00 55.50           C  
ATOM    418  C   LEU A  64     -17.324  18.127  31.304  1.00 57.11           C  
ATOM    419  O   LEU A  64     -16.093  17.996  31.140  1.00 58.74           O  
ATOM    420  CB  LEU A  64     -19.061  19.715  30.522  1.00 56.62           C  
ATOM    421  CG  LEU A  64     -19.808  21.040  30.660  1.00 58.22           C  
ATOM    422  CD1 LEU A  64     -21.293  20.790  30.430  1.00 59.37           C  
ATOM    423  CD2 LEU A  64     -19.580  21.635  32.040  1.00 58.04           C  
ATOM    424  OXT LEU A  64     -18.143  17.178  31.358  1.00 57.70           O  
TER     425      LEU A  64                                                      
ATOM    426  N   SER B  39     -13.720  -3.401  17.275  1.00 58.47           N  
ATOM    427  CA  SER B  39     -14.362  -2.351  18.115  1.00 57.58           C  
ATOM    428  C   SER B  39     -13.310  -1.576  18.903  1.00 56.28           C  
ATOM    429  O   SER B  39     -12.244  -1.252  18.377  1.00 56.57           O  
ATOM    430  CB  SER B  39     -15.365  -2.991  19.079  1.00 59.00           C  
ATOM    431  OG  SER B  39     -14.721  -3.902  19.953  1.00 61.35           O  
ATOM    432  N   ALA B  40     -13.611  -1.286  20.164  1.00 53.32           N  
ATOM    433  CA  ALA B  40     -12.690  -0.544  21.012  1.00 50.57           C  
ATOM    434  C   ALA B  40     -11.396  -1.314  21.239  1.00 49.80           C  
ATOM    435  O   ALA B  40     -11.406  -2.534  21.407  1.00 50.30           O  
ATOM    436  CB  ALA B  40     -13.348  -0.230  22.346  1.00 50.99           C  
ATOM    437  N   LEU B  41     -10.281  -0.591  21.237  1.00 45.57           N  
ATOM    438  CA  LEU B  41      -8.971  -1.193  21.454  1.00 43.28           C  
ATOM    439  C   LEU B  41      -8.783  -1.539  22.932  1.00 42.24           C  
ATOM    440  O   LEU B  41      -9.236  -0.808  23.814  1.00 41.16           O  
ATOM    441  CB  LEU B  41      -7.877  -0.227  20.990  1.00 40.27           C  
ATOM    442  CG  LEU B  41      -7.494  -0.187  19.501  1.00 40.88           C  
ATOM    443  CD1 LEU B  41      -8.630  -0.665  18.610  1.00 37.72           C  
ATOM    444  CD2 LEU B  41      -7.069   1.232  19.143  1.00 37.68           C  
ATOM    445  N   ALA B  42      -8.113  -2.655  23.200  1.00 41.11           N  
ATOM    446  CA  ALA B  42      -7.891  -3.093  24.576  1.00 40.48           C  
ATOM    447  C   ALA B  42      -6.610  -2.524  25.169  1.00 39.24           C  
ATOM    448  O   ALA B  42      -5.830  -1.868  24.477  1.00 38.76           O  
ATOM    449  CB  ALA B  42      -7.864  -4.618  24.639  1.00 39.75           C  
ATOM    450  N   GLU B  43      -6.403  -2.771  26.460  1.00 39.27           N  
ATOM    451  CA  GLU B  43      -5.213  -2.288  27.150  1.00 38.65           C  
ATOM    452  C   GLU B  43      -3.965  -2.962  26.586  1.00 37.56           C  
ATOM    453  O   GLU B  43      -3.904  -4.188  26.486  1.00 37.11           O  
ATOM    454  CB  GLU B  43      -5.316  -2.573  28.655  1.00 41.85           C  
ATOM    455  CG  GLU B  43      -4.159  -1.998  29.472  1.00 45.40           C  
ATOM    456  CD  GLU B  43      -4.231  -2.364  30.948  1.00 47.82           C  
ATOM    457  OE1 GLU B  43      -5.227  -2.012  31.614  1.00 50.74           O  
ATOM    458  OE2 GLU B  43      -3.283  -3.006  31.444  1.00 49.75           O  
ATOM    459  N   GLY B  44      -2.974  -2.156  26.218  1.00 35.48           N  
ATOM    460  CA  GLY B  44      -1.740  -2.691  25.670  1.00 33.93           C  
ATOM    461  C   GLY B  44      -1.711  -2.703  24.152  1.00 32.93           C  
ATOM    462  O   GLY B  44      -0.666  -2.932  23.542  1.00 32.61           O  
ATOM    463  N   GLN B  45      -2.859  -2.446  23.535  1.00 31.74           N  
ATOM    464  CA  GLN B  45      -2.949  -2.447  22.081  1.00 30.82           C  
ATOM    465  C   GLN B  45      -2.556  -1.097  21.481  1.00 30.79           C  
ATOM    466  O   GLN B  45      -2.806  -0.045  22.067  1.00 31.74           O  
ATOM    467  CB  GLN B  45      -4.373  -2.818  21.653  1.00 31.47           C  
ATOM    468  CG  GLN B  45      -4.530  -3.118  20.164  1.00 31.16           C  
ATOM    469  CD  GLN B  45      -5.929  -3.615  19.810  1.00 30.41           C  
ATOM    470  OE1 GLN B  45      -6.200  -3.967  18.664  1.00 30.09           O  
ATOM    471  NE2 GLN B  45      -6.816  -3.650  20.797  1.00 29.72           N  
ATOM    472  N   SER B  46      -1.930  -1.127  20.310  1.00 29.55           N  
ATOM    473  CA  SER B  46      -1.529   0.107  19.647  1.00 29.84           C  
ATOM    474  C   SER B  46      -2.750   0.975  19.347  1.00 27.63           C  
ATOM    475  O   SER B  46      -3.851   0.467  19.134  1.00 26.91           O  
ATOM    476  CB  SER B  46      -0.772  -0.208  18.358  1.00 28.36           C  
ATOM    477  OG  SER B  46       0.549  -0.617  18.664  1.00 34.06           O  
ATOM    478  N   CYS B  47      -2.543   2.287  19.332  1.00 27.18           N  
ATOM    479  CA  CYS B  47      -3.619   3.233  19.083  1.00 25.85           C  
ATOM    480  C   CYS B  47      -3.033   4.544  18.572  1.00 26.46           C  
ATOM    481  O   CYS B  47      -1.831   4.790  18.685  1.00 28.40           O  
ATOM    482  CB  CYS B  47      -4.388   3.499  20.389  1.00 25.30           C  
ATOM    483  SG  CYS B  47      -3.300   4.101  21.724  1.00 28.90           S  
ATOM    484  N   GLY B  48      -3.895   5.389  18.018  1.00 25.42           N  
ATOM    485  CA  GLY B  48      -3.441   6.670  17.518  1.00 24.68           C  
ATOM    486  C   GLY B  48      -4.594   7.619  17.293  1.00 24.57           C  
ATOM    487  O   GLY B  48      -5.754   7.265  17.497  1.00 24.39           O  
ATOM    488  N   VAL B  49      -4.276   8.832  16.866  1.00 25.01           N  
ATOM    489  CA  VAL B  49      -5.297   9.833  16.599  1.00 24.08           C  
ATOM    490  C   VAL B  49      -6.320   9.349  15.576  1.00 25.55           C  
ATOM    491  O   VAL B  49      -7.507   9.628  15.701  1.00 27.63           O  
ATOM    492  CB  VAL B  49      -4.652  11.139  16.072  1.00 23.73           C  
ATOM    493  CG1 VAL B  49      -5.724  12.123  15.636  1.00 23.71           C  
ATOM    494  CG2 VAL B  49      -3.784  11.748  17.150  1.00 21.54           C  
ATOM    495  N   TYR B  50      -5.859   8.603  14.577  1.00 27.40           N  
ATOM    496  CA  TYR B  50      -6.735   8.131  13.510  1.00 28.08           C  
ATOM    497  C   TYR B  50      -7.173   6.663  13.549  1.00 29.31           C  
ATOM    498  O   TYR B  50      -7.685   6.148  12.556  1.00 31.59           O  
ATOM    499  CB  TYR B  50      -6.067   8.426  12.168  1.00 26.58           C  
ATOM    500  CG  TYR B  50      -5.626   9.868  12.032  1.00 26.76           C  
ATOM    501  CD1 TYR B  50      -6.561  10.888  11.835  1.00 24.56           C  
ATOM    502  CD2 TYR B  50      -4.274  10.218  12.127  1.00 23.57           C  
ATOM    503  CE1 TYR B  50      -6.164  12.218  11.736  1.00 23.17           C  
ATOM    504  CE2 TYR B  50      -3.866  11.546  12.030  1.00 24.76           C  
ATOM    505  CZ  TYR B  50      -4.817  12.541  11.834  1.00 19.86           C  
ATOM    506  OH  TYR B  50      -4.420  13.854  11.736  1.00 20.16           O  
ATOM    507  N   THR B  51      -6.981   5.991  14.679  1.00 29.31           N  
ATOM    508  CA  THR B  51      -7.384   4.591  14.800  1.00 28.76           C  
ATOM    509  C   THR B  51      -8.672   4.545  15.600  1.00 30.25           C  
ATOM    510  O   THR B  51      -9.198   5.584  15.997  1.00 29.66           O  
ATOM    511  CB  THR B  51      -6.333   3.742  15.566  1.00 27.30           C  
ATOM    512  OG1 THR B  51      -6.285   4.165  16.935  1.00 27.10           O  
ATOM    513  CG2 THR B  51      -4.944   3.896  14.944  1.00 25.06           C  
ATOM    514  N   GLU B  52      -9.187   3.343  15.832  1.00 32.77           N  
ATOM    515  CA  GLU B  52     -10.393   3.198  16.634  1.00 35.03           C  
ATOM    516  C   GLU B  52      -9.995   3.682  18.021  1.00 34.86           C  
ATOM    517  O   GLU B  52      -8.806   3.718  18.356  1.00 32.99           O  
ATOM    518  CB  GLU B  52     -10.827   1.730  16.707  1.00 38.95           C  
ATOM    519  CG  GLU B  52     -11.317   1.146  15.395  1.00 42.98           C  
ATOM    520  CD  GLU B  52     -12.554   1.852  14.872  1.00 48.93           C  
ATOM    521  OE1 GLU B  52     -13.516   2.021  15.653  1.00 49.81           O  
ATOM    522  OE2 GLU B  52     -12.566   2.233  13.680  1.00 49.71           O  
ATOM    523  N   ARG B  53     -10.977   4.050  18.831  1.00 36.33           N  
ATOM    524  CA  ARG B  53     -10.691   4.528  20.174  1.00 38.61           C  
ATOM    525  C   ARG B  53     -10.412   3.397  21.153  1.00 37.36           C  
ATOM    526  O   ARG B  53     -10.854   2.263  20.953  1.00 37.28           O  
ATOM    527  CB  ARG B  53     -11.853   5.389  20.675  1.00 43.21           C  
ATOM    528  CG  ARG B  53     -11.988   6.685  19.897  1.00 49.72           C  
ATOM    529  CD  ARG B  53     -13.194   7.500  20.324  1.00 56.57           C  
ATOM    530  NE  ARG B  53     -13.145   7.890  21.729  1.00 61.53           N  
ATOM    531  CZ  ARG B  53     -13.987   8.753  22.288  1.00 63.65           C  
ATOM    532  NH1 ARG B  53     -14.939   9.316  21.556  1.00 64.66           N  
ATOM    533  NH2 ARG B  53     -13.878   9.054  23.575  1.00 65.21           N  
ATOM    534  N   CYS B  54      -9.655   3.711  22.201  1.00 35.80           N  
ATOM    535  CA  CYS B  54      -9.324   2.733  23.232  1.00 37.19           C  
ATOM    536  C   CYS B  54     -10.600   2.430  24.001  1.00 39.75           C  
ATOM    537  O   CYS B  54     -11.555   3.205  23.949  1.00 39.46           O  
ATOM    538  CB  CYS B  54      -8.283   3.289  24.210  1.00 32.76           C  
ATOM    539  SG  CYS B  54      -6.595   3.539  23.563  1.00 31.75           S  
ATOM    540  N   ALA B  55     -10.612   1.311  24.722  1.00 39.90           N  
ATOM    541  CA  ALA B  55     -11.782   0.929  25.496  1.00 42.01           C  
ATOM    542  C   ALA B  55     -11.980   1.909  26.643  1.00 43.33           C  
ATOM    543  O   ALA B  55     -11.035   2.562  27.090  1.00 44.41           O  
ATOM    544  CB  ALA B  55     -11.620  -0.493  26.035  1.00 40.89           C  
ATOM    545  N   GLN B  56     -13.217   2.005  27.114  1.00 46.27           N  
ATOM    546  CA  GLN B  56     -13.569   2.900  28.209  1.00 46.98           C  
ATOM    547  C   GLN B  56     -12.649   2.685  29.405  1.00 46.86           C  
ATOM    548  O   GLN B  56     -12.315   1.549  29.746  1.00 46.71           O  
ATOM    549  CB  GLN B  56     -15.020   2.661  28.631  1.00 49.45           C  
ATOM    550  CG  GLN B  56     -16.030   2.703  27.487  1.00 52.92           C  
ATOM    551  CD  GLN B  56     -16.073   1.414  26.671  1.00 55.64           C  
ATOM    552  OE1 GLN B  56     -15.076   0.999  26.077  1.00 54.71           O  
ATOM    553  NE2 GLN B  56     -17.240   0.777  26.641  1.00 55.29           N  
ATOM    554  N   GLY B  57     -12.242   3.779  30.040  1.00 46.46           N  
ATOM    555  CA  GLY B  57     -11.366   3.679  31.193  1.00 45.89           C  
ATOM    556  C   GLY B  57      -9.903   3.715  30.799  1.00 46.63           C  
ATOM    557  O   GLY B  57      -9.017   3.747  31.653  1.00 47.54           O  
ATOM    558  N   LEU B  58      -9.650   3.707  29.496  1.00 45.76           N  
ATOM    559  CA  LEU B  58      -8.290   3.745  28.974  1.00 44.32           C  
ATOM    560  C   LEU B  58      -8.153   4.923  28.009  1.00 43.40           C  
ATOM    561  O   LEU B  58      -9.143   5.390  27.441  1.00 42.14           O  
ATOM    562  CB  LEU B  58      -7.982   2.450  28.212  1.00 45.02           C  
ATOM    563  CG  LEU B  58      -8.134   1.093  28.908  1.00 45.27           C  
ATOM    564  CD1 LEU B  58      -8.043  -0.017  27.872  1.00 44.01           C  
ATOM    565  CD2 LEU B  58      -7.060   0.928  29.970  1.00 44.12           C  
ATOM    566  N   ARG B  59      -6.929   5.407  27.836  1.00 40.99           N  
ATOM    567  CA  ARG B  59      -6.674   6.487  26.899  1.00 41.20           C  
ATOM    568  C   ARG B  59      -5.382   6.183  26.149  1.00 38.98           C  
ATOM    569  O   ARG B  59      -4.509   5.465  26.648  1.00 37.23           O  
ATOM    570  CB  ARG B  59      -6.593   7.853  27.604  1.00 42.80           C  
ATOM    571  CG  ARG B  59      -5.456   8.032  28.582  1.00 48.53           C  
ATOM    572  CD  ARG B  59      -5.366   9.484  29.058  1.00 50.94           C  
ATOM    573  NE  ARG B  59      -5.012  10.404  27.977  1.00 54.00           N  
ATOM    574  CZ  ARG B  59      -4.944  11.728  28.108  1.00 55.67           C  
ATOM    575  NH1 ARG B  59      -5.208  12.300  29.276  1.00 55.62           N  
ATOM    576  NH2 ARG B  59      -4.607  12.485  27.070  1.00 54.65           N  
ATOM    577  N   CYS B  60      -5.277   6.724  24.941  1.00 34.30           N  
ATOM    578  CA  CYS B  60      -4.121   6.504  24.097  1.00 34.00           C  
ATOM    579  C   CYS B  60      -2.931   7.400  24.451  1.00 34.57           C  
ATOM    580  O   CYS B  60      -2.995   8.617  24.305  1.00 34.82           O  
ATOM    581  CB  CYS B  60      -4.527   6.698  22.630  1.00 31.12           C  
ATOM    582  SG  CYS B  60      -3.259   6.122  21.472  1.00 28.31           S  
ATOM    583  N   LEU B  61      -1.846   6.785  24.919  1.00 35.17           N  
ATOM    584  CA  LEU B  61      -0.637   7.516  25.295  1.00 37.27           C  
ATOM    585  C   LEU B  61       0.571   7.005  24.539  1.00 37.81           C  
ATOM    586  O   LEU B  61       0.640   5.830  24.187  1.00 37.72           O  
ATOM    587  CB  LEU B  61      -0.345   7.379  26.794  1.00 36.88           C  
ATOM    588  CG  LEU B  61      -1.281   8.031  27.804  1.00 39.20           C  
ATOM    589  CD1 LEU B  61      -1.388   9.534  27.548  1.00 37.47           C  
ATOM    590  CD2 LEU B  61      -2.625   7.367  27.702  1.00 40.69           C  
ATOM    591  N   PRO B  62       1.553   7.885  24.293  1.00 40.67           N  
ATOM    592  CA  PRO B  62       2.771   7.512  23.573  1.00 43.32           C  
ATOM    593  C   PRO B  62       3.806   6.884  24.502  1.00 45.58           C  
ATOM    594  O   PRO B  62       3.670   6.939  25.723  1.00 43.82           O  
ATOM    595  CB  PRO B  62       3.245   8.843  23.011  1.00 42.71           C  
ATOM    596  CG  PRO B  62       2.918   9.781  24.133  1.00 41.70           C  
ATOM    597  CD  PRO B  62       1.530   9.335  24.565  1.00 42.50           C  
ATOM    598  N   ARG B  63       4.834   6.283  23.913  1.00 48.66           N  
ATOM    599  CA  ARG B  63       5.910   5.663  24.678  1.00 52.24           C  
ATOM    600  C   ARG B  63       6.731   6.811  25.261  1.00 53.02           C  
ATOM    601  O   ARG B  63       7.001   7.790  24.565  1.00 52.38           O  
ATOM    602  CB  ARG B  63       6.805   4.830  23.757  1.00 54.66           C  
ATOM    603  CG  ARG B  63       6.073   4.003  22.705  1.00 57.98           C  
ATOM    604  CD  ARG B  63       5.569   2.675  23.239  1.00 60.28           C  
ATOM    605  NE  ARG B  63       5.043   1.841  22.159  1.00 63.63           N  
ATOM    606  CZ  ARG B  63       4.710   0.561  22.294  1.00 64.74           C  
ATOM    607  NH1 ARG B  63       4.847  -0.043  23.467  1.00 64.62           N  
ATOM    608  NH2 ARG B  63       4.239  -0.116  21.254  1.00 64.94           N  
ATOM    609  N   GLN B  64       7.132   6.694  26.524  1.00 54.59           N  
ATOM    610  CA  GLN B  64       7.918   7.746  27.161  1.00 56.19           C  
ATOM    611  C   GLN B  64       9.278   7.975  26.508  1.00 54.95           C  
ATOM    612  O   GLN B  64       9.976   8.924  26.852  1.00 55.19           O  
ATOM    613  CB  GLN B  64       8.112   7.454  28.654  1.00 58.46           C  
ATOM    614  CG  GLN B  64       6.844   7.599  29.483  1.00 62.16           C  
ATOM    615  CD  GLN B  64       7.117   7.649  30.977  1.00 64.31           C  
ATOM    616  OE1 GLN B  64       6.189   7.677  31.787  1.00 65.56           O  
ATOM    617  NE2 GLN B  64       8.393   7.669  31.349  1.00 65.48           N  
ATOM    618  N   ASP B  65       9.653   7.117  25.566  1.00 54.23           N  
ATOM    619  CA  ASP B  65      10.936   7.273  24.888  1.00 54.67           C  
ATOM    620  C   ASP B  65      10.795   7.952  23.524  1.00 54.03           C  
ATOM    621  O   ASP B  65      11.772   8.089  22.786  1.00 54.88           O  
ATOM    622  CB  ASP B  65      11.622   5.914  24.714  1.00 56.29           C  
ATOM    623  CG  ASP B  65      10.868   4.995  23.776  1.00 57.63           C  
ATOM    624  OD1 ASP B  65       9.738   4.586  24.119  1.00 57.64           O  
ATOM    625  OD2 ASP B  65      11.407   4.684  22.693  1.00 58.07           O  
ATOM    626  N   GLU B  66       9.581   8.376  23.188  1.00 52.05           N  
ATOM    627  CA  GLU B  66       9.346   9.044  21.912  1.00 50.06           C  
ATOM    628  C   GLU B  66       9.952  10.443  21.938  1.00 49.71           C  
ATOM    629  O   GLU B  66       9.778  11.183  22.905  1.00 49.58           O  
ATOM    630  CB  GLU B  66       7.841   9.145  21.629  1.00 47.94           C  
ATOM    631  CG  GLU B  66       7.164   7.825  21.284  1.00 45.31           C  
ATOM    632  CD  GLU B  66       7.504   7.334  19.885  1.00 44.11           C  
ATOM    633  OE1 GLU B  66       8.316   7.987  19.197  1.00 44.31           O  
ATOM    634  OE2 GLU B  66       6.958   6.291  19.468  1.00 43.74           O  
ATOM    635  N   GLU B  67      10.668  10.799  20.876  1.00 49.99           N  
ATOM    636  CA  GLU B  67      11.275  12.123  20.775  1.00 50.53           C  
ATOM    637  C   GLU B  67      10.139  13.125  20.547  1.00 48.30           C  
ATOM    638  O   GLU B  67      10.140  14.229  21.092  1.00 47.77           O  
ATOM    639  CB  GLU B  67      12.245  12.170  19.591  1.00 53.83           C  
ATOM    640  CG  GLU B  67      13.195  10.979  19.489  1.00 59.06           C  
ATOM    641  CD  GLU B  67      14.234  10.942  20.595  1.00 62.91           C  
ATOM    642  OE1 GLU B  67      13.845  10.864  21.780  1.00 64.79           O  
ATOM    643  OE2 GLU B  67      15.443  10.987  20.276  1.00 64.81           O  
ATOM    644  N   LYS B  68       9.170  12.715  19.733  1.00 44.89           N  
ATOM    645  CA  LYS B  68       8.010  13.537  19.404  1.00 41.91           C  
ATOM    646  C   LYS B  68       6.757  12.753  19.786  1.00 36.81           C  
ATOM    647  O   LYS B  68       6.151  12.096  18.944  1.00 36.07           O  
ATOM    648  CB  LYS B  68       7.980  13.821  17.903  1.00 44.05           C  
ATOM    649  CG  LYS B  68       9.325  14.192  17.299  1.00 48.60           C  
ATOM    650  CD  LYS B  68       9.857  15.501  17.840  1.00 51.03           C  
ATOM    651  CE  LYS B  68      11.163  15.858  17.156  1.00 54.19           C  
ATOM    652  NZ  LYS B  68      11.008  15.877  15.673  1.00 54.98           N  
ATOM    653  N   PRO B  69       6.352  12.814  21.064  1.00 33.10           N  
ATOM    654  CA  PRO B  69       5.166  12.094  21.540  1.00 30.73           C  
ATOM    655  C   PRO B  69       3.895  12.383  20.738  1.00 28.46           C  
ATOM    656  O   PRO B  69       3.145  11.466  20.407  1.00 26.39           O  
ATOM    657  CB  PRO B  69       5.032  12.557  22.993  1.00 29.25           C  
ATOM    658  CG  PRO B  69       6.414  12.979  23.366  1.00 33.62           C  
ATOM    659  CD  PRO B  69       6.900  13.675  22.126  1.00 31.55           C  
ATOM    660  N   LEU B  70       3.647  13.657  20.445  1.00 26.72           N  
ATOM    661  CA  LEU B  70       2.447  14.033  19.700  1.00 27.00           C  
ATOM    662  C   LEU B  70       2.485  13.438  18.306  1.00 26.72           C  
ATOM    663  O   LEU B  70       1.488  12.881  17.829  1.00 25.47           O  
ATOM    664  CB  LEU B  70       2.311  15.559  19.632  1.00 25.43           C  
ATOM    665  CG  LEU B  70       2.028  16.231  20.981  1.00 25.63           C  
ATOM    666  CD1 LEU B  70       1.938  17.740  20.801  1.00 26.23           C  
ATOM    667  CD2 LEU B  70       0.727  15.684  21.565  1.00 23.13           C  
ATOM    668  N   HIS B  71       3.638  13.545  17.653  1.00 26.27           N  
ATOM    669  CA  HIS B  71       3.787  12.978  16.322  1.00 26.43           C  
ATOM    670  C   HIS B  71       3.654  11.457  16.381  1.00 25.51           C  
ATOM    671  O   HIS B  71       3.177  10.841  15.434  1.00 26.07           O  
ATOM    672  CB  HIS B  71       5.129  13.384  15.702  1.00 26.14           C  
ATOM    673  CG  HIS B  71       5.135  14.777  15.153  1.00 28.44           C  
ATOM    674  ND1 HIS B  71       5.291  15.893  15.947  1.00 28.51           N  
ATOM    675  CD2 HIS B  71       4.945  15.236  13.893  1.00 29.08           C  
ATOM    676  CE1 HIS B  71       5.196  16.979  15.201  1.00 28.30           C  
ATOM    677  NE2 HIS B  71       4.985  16.607  13.951  1.00 30.59           N  
ATOM    678  N   ALA B  72       4.048  10.853  17.499  1.00 25.45           N  
ATOM    679  CA  ALA B  72       3.939   9.400  17.643  1.00 26.65           C  
ATOM    680  C   ALA B  72       2.467   8.996  17.660  1.00 27.13           C  
ATOM    681  O   ALA B  72       2.083   7.976  17.086  1.00 26.66           O  
ATOM    682  CB  ALA B  72       4.620   8.936  18.927  1.00 26.26           C  
ATOM    683  N   LEU B  73       1.650   9.805  18.327  1.00 26.56           N  
ATOM    684  CA  LEU B  73       0.219   9.552  18.423  1.00 27.39           C  
ATOM    685  C   LEU B  73      -0.458   9.717  17.069  1.00 24.51           C  
ATOM    686  O   LEU B  73      -1.336   8.939  16.703  1.00 24.68           O  
ATOM    687  CB  LEU B  73      -0.412  10.502  19.442  1.00 30.38           C  
ATOM    688  CG  LEU B  73      -0.845   9.899  20.780  1.00 35.02           C  
ATOM    689  CD1 LEU B  73       0.235   8.981  21.334  1.00 37.66           C  
ATOM    690  CD2 LEU B  73      -1.146  11.031  21.749  1.00 34.89           C  
ATOM    691  N   LEU B  74      -0.044  10.737  16.327  1.00 25.25           N  
ATOM    692  CA  LEU B  74      -0.598  10.988  15.005  1.00 23.89           C  
ATOM    693  C   LEU B  74      -0.287   9.807  14.090  1.00 26.28           C  
ATOM    694  O   LEU B  74      -1.095   9.440  13.235  1.00 23.75           O  
ATOM    695  CB  LEU B  74      -0.006  12.280  14.423  1.00 22.63           C  
ATOM    696  CG  LEU B  74      -0.503  13.563  15.113  1.00 24.73           C  
ATOM    697  CD1 LEU B  74       0.428  14.725  14.804  1.00 24.97           C  
ATOM    698  CD2 LEU B  74      -1.937  13.864  14.663  1.00 23.07           C  
ATOM    699  N   HIS B  75       0.879   9.198  14.290  1.00 26.07           N  
ATOM    700  CA  HIS B  75       1.289   8.071  13.468  1.00 30.78           C  
ATOM    701  C   HIS B  75       0.935   6.703  14.052  1.00 32.10           C  
ATOM    702  O   HIS B  75       1.539   5.695  13.698  1.00 33.73           O  
ATOM    703  CB  HIS B  75       2.789   8.173  13.178  1.00 33.64           C  
ATOM    704  CG  HIS B  75       3.162   9.419  12.438  1.00 38.80           C  
ATOM    705  ND1 HIS B  75       2.718   9.683  11.160  1.00 41.10           N  
ATOM    706  CD2 HIS B  75       3.870  10.507  12.821  1.00 40.91           C  
ATOM    707  CE1 HIS B  75       3.133  10.881  10.789  1.00 41.21           C  
ATOM    708  NE2 HIS B  75       3.834  11.403  11.779  1.00 44.19           N  
ATOM    709  N   GLY B  76      -0.051   6.681  14.943  1.00 32.63           N  
ATOM    710  CA  GLY B  76      -0.508   5.436  15.541  1.00 32.02           C  
ATOM    711  C   GLY B  76       0.471   4.625  16.374  1.00 34.41           C  
ATOM    712  O   GLY B  76       0.343   3.399  16.446  1.00 34.43           O  
ATOM    713  N   ARG B  77       1.434   5.285  17.013  1.00 32.88           N  
ATOM    714  CA  ARG B  77       2.410   4.580  17.837  1.00 34.75           C  
ATOM    715  C   ARG B  77       2.125   4.701  19.329  1.00 34.86           C  
ATOM    716  O   ARG B  77       2.996   4.458  20.161  1.00 36.41           O  
ATOM    717  CB  ARG B  77       3.828   5.075  17.538  1.00 35.67           C  
ATOM    718  CG  ARG B  77       4.297   4.757  16.126  1.00 37.36           C  
ATOM    719  CD  ARG B  77       5.807   4.695  16.057  1.00 37.48           C  
ATOM    720  NE  ARG B  77       6.435   5.956  16.436  1.00 38.77           N  
ATOM    721  CZ  ARG B  77       6.610   6.985  15.613  1.00 38.84           C  
ATOM    722  NH1 ARG B  77       6.204   6.909  14.355  1.00 38.80           N  
ATOM    723  NH2 ARG B  77       7.202   8.090  16.047  1.00 38.47           N  
ATOM    724  N   GLY B  78       0.900   5.082  19.669  1.00 33.38           N  
ATOM    725  CA  GLY B  78       0.545   5.190  21.068  1.00 31.84           C  
ATOM    726  C   GLY B  78       0.087   3.823  21.546  1.00 31.67           C  
ATOM    727  O   GLY B  78       0.032   2.871  20.767  1.00 31.30           O  
ATOM    728  N   VAL B  79      -0.239   3.721  22.824  1.00 31.21           N  
ATOM    729  CA  VAL B  79      -0.711   2.466  23.393  1.00 33.83           C  
ATOM    730  C   VAL B  79      -1.811   2.774  24.403  1.00 32.69           C  
ATOM    731  O   VAL B  79      -1.735   3.768  25.125  1.00 34.48           O  
ATOM    732  CB  VAL B  79       0.443   1.700  24.101  1.00 36.30           C  
ATOM    733  CG1 VAL B  79       1.096   2.589  25.140  1.00 39.47           C  
ATOM    734  CG2 VAL B  79      -0.094   0.436  24.760  1.00 38.17           C  
ATOM    735  N   CYS B  80      -2.842   1.939  24.432  1.00 32.38           N  
ATOM    736  CA  CYS B  80      -3.942   2.129  25.365  1.00 34.85           C  
ATOM    737  C   CYS B  80      -3.486   1.739  26.768  1.00 37.39           C  
ATOM    738  O   CYS B  80      -3.119   0.591  27.005  1.00 35.79           O  
ATOM    739  CB  CYS B  80      -5.144   1.270  24.964  1.00 32.27           C  
ATOM    740  SG  CYS B  80      -5.879   1.648  23.342  1.00 34.08           S  
ATOM    741  N   LEU B  81      -3.509   2.700  27.689  1.00 42.01           N  
ATOM    742  CA  LEU B  81      -3.091   2.463  29.070  1.00 46.11           C  
ATOM    743  C   LEU B  81      -4.095   2.988  30.093  1.00 49.50           C  
ATOM    744  O   LEU B  81      -5.128   3.556  29.741  1.00 48.23           O  
ATOM    745  CB  LEU B  81      -1.729   3.114  29.337  1.00 46.36           C  
ATOM    746  CG  LEU B  81      -0.510   2.625  28.548  1.00 47.24           C  
ATOM    747  CD1 LEU B  81       0.680   3.510  28.871  1.00 47.79           C  
ATOM    748  CD2 LEU B  81      -0.206   1.174  28.885  1.00 45.42           C  
ATOM    749  N   ASN B  82      -3.750   2.790  31.363  1.00 54.82           N  
ATOM    750  CA  ASN B  82      -4.541   3.195  32.527  1.00 59.40           C  
ATOM    751  C   ASN B  82      -5.487   4.394  32.410  1.00 61.49           C  
ATOM    752  O   ASN B  82      -6.503   4.339  31.719  1.00 61.26           O  
ATOM    753  CB  ASN B  82      -3.602   3.443  33.711  1.00 61.17           C  
ATOM    754  CG  ASN B  82      -2.493   4.426  33.378  1.00 62.57           C  
ATOM    755  OD1 ASN B  82      -2.714   5.414  32.677  1.00 64.48           O  
ATOM    756  ND2 ASN B  82      -1.295   4.165  33.887  1.00 62.95           N  
ATOM    757  N   GLU B  83      -5.141   5.458  33.134  1.00 64.37           N  
ATOM    758  CA  GLU B  83      -5.910   6.700  33.202  1.00 66.99           C  
ATOM    759  C   GLU B  83      -6.939   6.864  32.096  1.00 67.27           C  
ATOM    760  O   GLU B  83      -8.128   7.052  32.426  1.00 68.26           O  
ATOM    761  CB  GLU B  83      -4.964   7.905  33.200  1.00 68.36           C  
ATOM    762  CG  GLU B  83      -3.745   7.748  34.100  1.00 70.54           C  
ATOM    763  CD  GLU B  83      -4.079   7.137  35.448  1.00 71.94           C  
ATOM    764  OE1 GLU B  83      -4.920   7.708  36.172  1.00 73.55           O  
ATOM    765  OE2 GLU B  83      -3.496   6.084  35.783  1.00 72.89           O  
ATOM    766  OXT GLU B  83      -6.545   6.810  30.915  1.00 69.07           O  
TER     767      GLU B  83                                                      
HETATM  768  O   HOH A2001      -6.959  25.238  10.263  1.00 54.50           O  
HETATM  769  O   HOH A2002      -9.932  24.512   6.606  1.00 48.25           O  
HETATM  770  O   HOH A2003      -3.808  24.960   7.754  1.00 67.71           O  
HETATM  771  O   HOH A2004       2.515  20.323  12.519  1.00 42.58           O  
HETATM  772  O   HOH A2005      -2.241  21.870   7.572  1.00 48.21           O  
HETATM  773  O   HOH A2006       2.752  16.695   8.509  1.00 59.59           O  
HETATM  774  O   HOH A2007       4.162  17.600  11.512  1.00 48.15           O  
HETATM  775  O   HOH A2008      -0.597  19.777   9.560  1.00 40.19           O  
HETATM  776  O   HOH A2009      -5.667  31.612  15.738  1.00 53.82           O  
HETATM  777  O   HOH A2010     -14.590  17.960  14.582  1.00 46.20           O  
HETATM  778  O   HOH A2011      -7.378  11.115  23.652  1.00 41.42           O  
HETATM  779  O   HOH A2012     -13.498  26.961  19.475  1.00 26.29           O  
HETATM  780  O   HOH A2013      -5.002  30.025  18.420  1.00 36.23           O  
HETATM  781  O   HOH A2014      -6.625  37.630  21.651  1.00 61.08           O  
HETATM  782  O   HOH A2015     -10.623  35.486  23.247  1.00 48.03           O  
HETATM  783  O   HOH A2016      -8.400  32.856  29.980  1.00 60.13           O  
HETATM  784  O   HOH A2017      -1.831  38.943  35.406  0.50 67.81           O  
HETATM  785  O   HOH A2018      -0.454  33.470  16.194  1.00 44.55           O  
HETATM  786  O   HOH A2019      -2.644  31.927  18.931  1.00 37.23           O  
HETATM  787  O   HOH A2020       3.964  25.988  25.041  1.00 54.34           O  
HETATM  788  O   HOH A2021       7.236  20.067  23.369  1.00 42.55           O  
HETATM  789  O   HOH A2022       5.133  17.056  23.108  1.00 30.14           O  
HETATM  790  O   HOH A2023       3.849  23.009  26.307  1.00 55.69           O  
HETATM  791  O   HOH A2024       6.971  19.806  27.054  1.00 62.02           O  
HETATM  792  O   HOH A2025       3.084  15.212  24.509  1.00 46.38           O  
HETATM  793  O   HOH A2026       2.633  16.411  28.461  1.00 38.79           O  
HETATM  794  O   HOH B2001       1.920  -3.265  24.783  1.00 57.34           O  
HETATM  795  O   HOH B2002      -4.078  -0.471  16.534  1.00 76.11           O  
HETATM  796  O   HOH B2003       2.278   1.311  19.768  1.00 44.76           O  
HETATM  797  O   HOH B2004      -7.124   5.979  19.437  1.00 36.83           O  
HETATM  798  O   HOH B2005      -3.143   7.399  14.215  1.00 29.35           O  
HETATM  799  O   HOH B2006      -9.710   8.110  16.167  1.00 45.79           O  
HETATM  800  O   HOH B2007      -8.092   0.771  14.789  1.00 47.22           O  
HETATM  801  O   HOH B2008     -13.597   3.240  18.060  1.00 44.21           O  
HETATM  802  O   HOH B2009      -8.565   6.277  22.112  1.00 34.63           O  
HETATM  803  O   HOH B2010      -7.512   8.258  24.298  1.00 34.80           O  
HETATM  804  O   HOH B2011      -4.408  10.918  24.751  1.00 29.96           O  
HETATM  805  O   HOH B2012       9.980   5.519  30.788  1.00 46.86           O  
HETATM  806  O   HOH B2013      11.682   8.280  18.689  1.00 78.53           O  
HETATM  807  O   HOH B2014      15.955   8.250  19.107  1.00 48.54           O  
HETATM  808  O   HOH B2015       9.154  10.467  18.403  1.00 53.88           O  
HETATM  809  O   HOH B2016      -1.894   1.792  15.573  1.00 42.85           O  
HETATM  810  O   HOH B2017       6.930  10.297  13.784  1.00 49.24           O  
HETATM  811  O   HOH B2018       5.123   4.904  12.841  1.00 49.26           O  
CONECT   37  288                                                                
CONECT  124  403                                                                
CONECT  282  322                                                                
CONECT  288   37                                                                
CONECT  322  282                                                                
CONECT  403  124                                                                
CONECT  483  582                                                                
CONECT  539  740                                                                
CONECT  582  483                                                                
CONECT  740  539                                                                
MASTER      326    0    0    5    3    0    0    6  809    2   10   11          
END

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Related entries of code: 1h59

Entries with 90% protein sequence similarity cutoff in PDBbind
PDB Code	Check Database	Protein Sequence Similarity
No similar entries are found!
Complexes with the same small molecule ligand
PDB Code	Check Database	Ligand Name
1wqj	RCSB PDB PDBbind	IGF-I

Entry Information

PDB ID	1h59
Complex Type	Protein-Protein
PDBbind Subset	general set
Protein Name	IGFBP-5
Ligand Name	IGF-I
EC.Number	E.C.-.-.-.-
Resolution	2.1(Å)
Affinity (Kd/Ki/IC50)	Kd=37nM
Release Year	2002
Protein/NA Sequence	Check fasta file
Primary Reference	The EMBO journal. (2001) 20, pp. 3638-44

Links to External Databases

RCSB PDB	The mother database
PDBsum	Enhanced annotations on PDB entries
Pubchem	Comprehensive collection of chemical and biological data
UniProtKB AC	UniProt accession number (AC): P24593 P05019
Entrez Gene ID	NCBI Entrez Gene ID: 3488 3479
ASD	Information of known allosteric effects of PDB entries

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