Welcome to PDBbind-CN database

Browse entries in the PDBbind-CN Database

HEADER    GENE REGULATION/RNA/DNA                 26-FEB-04   1SI2              
TITLE     CRYSTAL STRUCTURE OF THE PAZ DOMAIN OF HUMAN EIF2C1 IN                
TITLE    2 COMPLEX WITH A 9-MER SIRNA-LIKE DUPLEX OF DEOXYNUCLEOTIDE            
TITLE    3 OVERHANG                                                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 5'-R(*CP*GP*UP*GP*AP*CP*U)-D(P*CP*T)-3';                   
COMPND   3 CHAIN: B;                                                            
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2C 1;             
COMPND   7 CHAIN: A;                                                            
COMPND   8 FRAGMENT: PAZ DOMAIN (RESIDUES 225-369);                             
COMPND   9 SYNONYM: EIF2C 1, EIF-2C 1, PUTATIVE RNA-BINDING PROTEIN             
COMPND  10 Q99, ARGONAUTE 1;                                                    
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 SYNTHETIC: YES;                                                      
SOURCE   3 MOL_ID: 2;                                                           
SOURCE   4 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   5 ORGANISM_COMMON: HUMAN;                                              
SOURCE   6 ORGANISM_TAXID: 9606;                                                
SOURCE   7 GENE: EIF2C1;                                                        
SOURCE   8 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE   9 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  10 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE  11 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  12 EXPRESSION_SYSTEM_PLASMID: PET19B                                    
KEYWDS    PROTEIN-RNA COMPLEX, RNA INTERFERENCE, DOUBLE HELIX,                  
KEYWDS   2 OVERHANG, GENE REGULATION/RNA/DNA COMPLEX                            
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    K.YE,J.B.MA,D.PATEL                                                   
REVDAT   2   24-FEB-09 1SI2    1       VERSN                                    
REVDAT   1   25-MAY-04 1SI2    0                                                
JRNL        AUTH   J.B.MA,K.YE,D.J.PATEL                                        
JRNL        TITL   STRUCTURAL BASIS FOR OVERHANG-SPECIFIC SMALL                 
JRNL        TITL 2 INTERFERING RNA RECOGNITION BY THE PAZ DOMAIN.               
JRNL        REF    NATURE                        V. 429   318 2004              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   15152257                                                     
JRNL        DOI    10.1038/NATURE02519                                          
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.1                                              
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,             
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : ENGH & HUBER                                    
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.71                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL                           
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL                           
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 93.8                           
REMARK   3   NUMBER OF REFLECTIONS             : 5873                           
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.221                           
REMARK   3   FREE R VALUE                     : 0.261                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 9.900                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 581                             
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.011                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 10                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.60                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.69                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 88.30                        
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 504                          
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3130                       
REMARK   3   BIN FREE R VALUE                    : 0.3420                       
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 8.70                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 48                           
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.049                        
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 977                                     
REMARK   3   NUCLEIC ACID ATOMS       : 184                                     
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 16                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 62.30                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 51.50                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 0.89000                                              
REMARK   3    B22 (A**2) : 0.89000                                              
REMARK   3    B33 (A**2) : -1.77000                                             
REMARK   3    B12 (A**2) : 8.79000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.35                            
REMARK   3   ESD FROM SIGMAA              (A) : 0.35                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.45                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.45                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.007                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.20                            
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 21.10                           
REMARK   3   IMPROPER ANGLES        (DEGREES) : 1.13                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED                                
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.570 ; 1.500                
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 2.720 ; 2.000                
REMARK   3   SIDE-CHAIN BOND              (A**2) : 1.890 ; 2.000                
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 2.900 ; 2.500                
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : FLAT MODEL                                           
REMARK   3   KSOL        : 0.33                                                 
REMARK   3   BSOL        : 37.03                                                
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM                              
REMARK   3  PARAMETER FILE  2  : DNA-RNA_REP.PARAM                              
REMARK   3  PARAMETER FILE  3  : WATER_REP.PARAM                                
REMARK   3  PARAMETER FILE  4  : ION.PARAM                                      
REMARK   3  PARAMETER FILE  5  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP                                    
REMARK   3  TOPOLOGY FILE  2   : DNA-RNA.TOP                                    
REMARK   3  TOPOLOGY FILE  3   : WATER.TOP                                      
REMARK   3  TOPOLOGY FILE  4   : ION.TOP                                        
REMARK   3  TOPOLOGY FILE  5   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1SI2 COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-MAR-04.                  
REMARK 100 THE RCSB ID CODE IS RCSB021725.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 13-NOV-03                          
REMARK 200  TEMPERATURE           (KELVIN) : 100.0                              
REMARK 200  PH                             : 7.60                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 14-ID-B                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9810                             
REMARK 200  MONOCHROMATOR                  : DIAMOND (111) DOUBLE-CRYSTAL       
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH                        
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 6225                               
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.600                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.0                               
REMARK 200  DATA REDUNDANCY                : 10.200                             
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.08700                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 27.8000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.69                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0                              
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : 0.69600                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 3.100                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SAD                                            
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD                          
REMARK 200 SOFTWARE USED: CNS 1.1                                               
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 50.00                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.49                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: PEG 1000, POTASSIUM CHLORIDE, HEPES      
REMARK 280  -NAOH, DITHIOTHREITOL, PH 7.60, VAPOR DIFFUSION, HANGING DROP,      
REMARK 280  TEMPERATURE 293K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 64                             
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+1/3                                            
REMARK 290       3555   -X+Y,-X,Z+2/3                                           
REMARK 290       4555   -X,-Y,Z                                                 
REMARK 290       5555   Y,-X+Y,Z+1/3                                            
REMARK 290       6555   X-Y,X,Z+2/3                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       11.47933            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       22.95867            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   5  0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   5 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       11.47933            
REMARK 290   SMTRY1   6  0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       22.95867            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300 REMARK: THE BIOLOGICAL ASSEMBLE CONSISTS OF TWO PAZ DOMAINS          
REMARK 300 BOUND TO EACH END OF A 9-MER SIRNA-LIKE DUPLEX GENERATED FROM        
REMARK 300 THE PROTEIN MONOMER AND THE 9-MER SINGLE STRANDED RNA IN THE         
REMARK 300 ASYMMETRIC UNIT BY THE OPERATION: -X+1,-Y+2,Z.                       
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, A                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000      173.29342            
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLY A   221                                                      
REMARK 465     SER A   222                                                      
REMARK 465     HIS A   223                                                      
REMARK 465     LEU A   296                                                      
REMARK 465     GLU A   297                                                      
REMARK 465     SER A   298                                                      
REMARK 465     GLY A   299                                                      
REMARK 465     GLN A   300                                                      
REMARK 465     THR A   301                                                      
REMARK 465     CYS A   350                                                      
REMARK 465     ILE A   351                                                      
REMARK 465     LYS A   352                                                      
REMARK 465     LYS A   353                                                      
REMARK 465     LEU A   354                                                      
REMARK 465     THR A   355                                                      
REMARK 465     ASP A   356                                                      
REMARK 465     ASN A   357                                                      
REMARK 465     GLN A   358                                                      
REMARK 465     THR A   359                                                      
REMARK 465     SER A   360                                                      
REMARK 465     THR A   361                                                      
REMARK 465     MET A   362                                                      
REMARK 465     ILE A   363                                                      
REMARK 465     LYS A   364                                                      
REMARK 465     ALA A   365                                                      
REMARK 465     THR A   366                                                      
REMARK 465     ALA A   367                                                      
REMARK 465     ARG A   368                                                      
REMARK 465     SER A   369                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;            
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     MET A 224    CG   SD   CE                                        
REMARK 470     GLN A 295    CG   CD   OE1  NE2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A 240       41.70   -102.72                                   
REMARK 500    ASP A 242       31.56    -98.68                                   
REMARK 500    GLU A 243      -30.84   -132.71                                   
REMARK 500    PRO A 245       28.10    -70.08                                   
REMARK 500    PRO A 247     -177.14    -68.32                                   
REMARK 500    PRO A 293       92.17    -65.17                                   
REMARK 500    GLN A 332       -9.45    -47.16                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1SI3   RELATED DB: PDB                                   
DBREF  1SI2 A  225   369  UNP    Q9UL18   I2C1_HUMAN     225    369             
DBREF  1SI2 B  401   409  PDB    1SI2     1SI2           401    409             
SEQADV 1SI2 GLY A  221  UNP  Q9UL18              CLONING ARTIFACT               
SEQADV 1SI2 SER A  222  UNP  Q9UL18              CLONING ARTIFACT               
SEQADV 1SI2 HIS A  223  UNP  Q9UL18              CLONING ARTIFACT               
SEQADV 1SI2 MET A  224  UNP  Q9UL18              CLONING ARTIFACT               
SEQRES   1 B    9    C   G   U   G   A   C   U  DC  DT                          
SEQRES   1 A  149  GLY SER HIS MET ALA GLN PRO VAL ILE GLU PHE MET CYS          
SEQRES   2 A  149  GLU VAL LEU ASP ILE ARG ASN ILE ASP GLU GLN PRO LYS          
SEQRES   3 A  149  PRO LEU THR ASP SER GLN ARG VAL ARG PHE THR LYS GLU          
SEQRES   4 A  149  ILE LYS GLY LEU LYS VAL GLU VAL THR HIS CYS GLY GLN          
SEQRES   5 A  149  MET LYS ARG LYS TYR ARG VAL CYS ASN VAL THR ARG ARG          
SEQRES   6 A  149  PRO ALA SER HIS GLN THR PHE PRO LEU GLN LEU GLU SER          
SEQRES   7 A  149  GLY GLN THR VAL GLU CYS THR VAL ALA GLN TYR PHE LYS          
SEQRES   8 A  149  GLN LYS TYR ASN LEU GLN LEU LYS TYR PRO HIS LEU PRO          
SEQRES   9 A  149  CYS LEU GLN VAL GLY GLN GLU GLN LYS HIS THR TYR LEU          
SEQRES  10 A  149  PRO LEU GLU VAL CYS ASN ILE VAL ALA GLY GLN ARG CYS          
SEQRES  11 A  149  ILE LYS LYS LEU THR ASP ASN GLN THR SER THR MET ILE          
SEQRES  12 A  149  LYS ALA THR ALA ARG SER                                      
FORMUL   3  HOH   *16(H2 O)                                                     
HELIX    1   1 VAL A  228  ASP A  237  1                                  10    
HELIX    2   2 THR A  249  LYS A  261  1                                  13    
HELIX    3   3 VAL A  306  LYS A  313  1                                   8    
SHEET    1   A 6 GLN A 226  PRO A 227  0                                        
SHEET    2   A 6 CYS A 342  ILE A 344 -1  O  ILE A 344   N  GLN A 226           
SHEET    3   A 6 LYS A 264  VAL A 267 -1  N  GLU A 266   O  ASN A 343           
SHEET    4   A 6 LYS A 276  PRO A 286 -1  O  TYR A 277   N  VAL A 265           
SHEET    5   A 6 PRO A 324  VAL A 328 -1  O  GLN A 327   N  ASN A 281           
SHEET    6   A 6 THR A 335  PRO A 338 -1  O  LEU A 337   N  LEU A 326           
SHEET    1   B 2 THR A 291  PRO A 293  0                                        
SHEET    2   B 2 GLU A 303  THR A 305 -1  O  CYS A 304   N  PHE A 292           
CRYST1  100.051  100.051   34.438  90.00  90.00 120.00 P 64          6          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.009995  0.005771  0.000000        0.00000                         
SCALE2      0.000000  0.011541  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.029038        0.00000                         
ATOM      1  O5'   C B 401      -5.751  86.006   3.780  1.00 55.95           O  
ATOM      2  C5'   C B 401      -6.276  85.084   4.727  1.00 53.19           C  
ATOM      3  C4'   C B 401      -7.284  84.178   4.064  1.00 52.96           C  
ATOM      4  O4'   C B 401      -8.342  84.996   3.493  1.00 52.83           O  
ATOM      5  C3'   C B 401      -6.797  83.380   2.864  1.00 52.58           C  
ATOM      6  O3'   C B 401      -6.071  82.208   3.226  1.00 51.82           O  
ATOM      7  C2'   C B 401      -8.112  83.033   2.181  1.00 52.86           C  
ATOM      8  O2'   C B 401      -8.795  81.976   2.828  1.00 52.53           O  
ATOM      9  C1'   C B 401      -8.884  84.343   2.354  1.00 52.64           C  
ATOM     10  N1    C B 401      -8.740  85.224   1.186  1.00 51.28           N  
ATOM     11  C2    C B 401      -9.536  84.975   0.064  1.00 50.72           C  
ATOM     12  O2    C B 401     -10.362  84.059   0.112  1.00 51.37           O  
ATOM     13  N3    C B 401      -9.394  85.740  -1.038  1.00 51.03           N  
ATOM     14  C4    C B 401      -8.512  86.740  -1.046  1.00 52.49           C  
ATOM     15  N4    C B 401      -8.415  87.473  -2.161  1.00 52.33           N  
ATOM     16  C5    C B 401      -7.691  87.033   0.092  1.00 52.39           C  
ATOM     17  C6    C B 401      -7.840  86.255   1.178  1.00 51.88           C  
ATOM     18  P     G B 402      -4.935  81.643   2.235  1.00 50.93           P  
ATOM     19  OP1   G B 402      -4.378  80.406   2.837  1.00 52.03           O  
ATOM     20  OP2   G B 402      -4.030  82.769   1.912  1.00 51.59           O  
ATOM     21  O5'   G B 402      -5.737  81.226   0.920  1.00 49.64           O  
ATOM     22  C5'   G B 402      -6.717  80.195   0.972  1.00 47.93           C  
ATOM     23  C4'   G B 402      -7.374  80.010  -0.375  1.00 47.53           C  
ATOM     24  O4'   G B 402      -8.184  81.168  -0.704  1.00 46.53           O  
ATOM     25  C3'   G B 402      -6.443  79.856  -1.564  1.00 47.20           C  
ATOM     26  O3'   G B 402      -5.982  78.521  -1.691  1.00 46.95           O  
ATOM     27  C2'   G B 402      -7.352  80.234  -2.726  1.00 47.42           C  
ATOM     28  O2'   G B 402      -8.191  79.174  -3.151  1.00 46.23           O  
ATOM     29  C1'   G B 402      -8.172  81.371  -2.109  1.00 47.30           C  
ATOM     30  N9    G B 402      -7.564  82.669  -2.368  1.00 48.16           N  
ATOM     31  C8    G B 402      -6.952  83.488  -1.450  1.00 49.31           C  
ATOM     32  N7    G B 402      -6.478  84.583  -1.975  1.00 49.39           N  
ATOM     33  C5    G B 402      -6.800  84.485  -3.322  1.00 49.78           C  
ATOM     34  C6    G B 402      -6.537  85.376  -4.397  1.00 49.60           C  
ATOM     35  O6    G B 402      -5.944  86.459  -4.372  1.00 50.49           O  
ATOM     36  N1    G B 402      -7.042  84.890  -5.598  1.00 48.76           N  
ATOM     37  C2    G B 402      -7.710  83.702  -5.751  1.00 48.23           C  
ATOM     38  N2    G B 402      -8.118  83.418  -6.991  1.00 47.49           N  
ATOM     39  N3    G B 402      -7.958  82.858  -4.760  1.00 49.10           N  
ATOM     40  C4    G B 402      -7.477  83.312  -3.580  1.00 49.21           C  
ATOM     41  P     U B 403      -4.534  78.243  -2.317  1.00 47.69           P  
ATOM     42  OP1   U B 403      -4.209  76.813  -2.075  1.00 48.57           O  
ATOM     43  OP2   U B 403      -3.610  79.291  -1.831  1.00 49.09           O  
ATOM     44  O5'   U B 403      -4.722  78.498  -3.875  1.00 46.00           O  
ATOM     45  C5'   U B 403      -5.549  77.664  -4.664  1.00 46.01           C  
ATOM     46  C4'   U B 403      -5.628  78.213  -6.064  1.00 48.16           C  
ATOM     47  O4'   U B 403      -6.240  79.530  -6.010  1.00 48.00           O  
ATOM     48  C3'   U B 403      -4.290  78.439  -6.764  1.00 48.49           C  
ATOM     49  O3'   U B 403      -3.832  77.232  -7.391  1.00 49.20           O  
ATOM     50  C2'   U B 403      -4.646  79.528  -7.774  1.00 47.50           C  
ATOM     51  O2'   U B 403      -5.318  79.031  -8.909  1.00 48.06           O  
ATOM     52  C1'   U B 403      -5.644  80.373  -6.978  1.00 47.87           C  
ATOM     53  N1    U B 403      -5.019  81.502  -6.282  1.00 47.81           N  
ATOM     54  C2    U B 403      -4.780  82.652  -7.012  1.00 46.99           C  
ATOM     55  O2    U B 403      -5.087  82.762  -8.177  1.00 45.43           O  
ATOM     56  N3    U B 403      -4.167  83.666  -6.318  1.00 47.93           N  
ATOM     57  C4    U B 403      -3.783  83.647  -4.991  1.00 48.65           C  
ATOM     58  O4    U B 403      -3.254  84.644  -4.503  1.00 50.33           O  
ATOM     59  C5    U B 403      -4.076  82.426  -4.299  1.00 48.62           C  
ATOM     60  C6    U B 403      -4.673  81.421  -4.952  1.00 48.26           C  
ATOM     61  P     G B 404      -2.260  76.864  -7.393  1.00 49.86           P  
ATOM     62  OP1   G B 404      -2.086  75.427  -7.723  1.00 51.00           O  
ATOM     63  OP2   G B 404      -1.671  77.404  -6.148  1.00 49.66           O  
ATOM     64  O5'   G B 404      -1.674  77.719  -8.595  1.00 51.34           O  
ATOM     65  C5'   G B 404      -2.101  77.485  -9.928  1.00 55.21           C  
ATOM     66  C4'   G B 404      -1.831  78.700 -10.770  1.00 56.69           C  
ATOM     67  O4'   G B 404      -2.664  79.790 -10.294  1.00 57.33           O  
ATOM     68  C3'   G B 404      -0.414  79.252 -10.682  1.00 57.03           C  
ATOM     69  O3'   G B 404       0.492  78.554 -11.537  1.00 57.45           O  
ATOM     70  C2'   G B 404      -0.623  80.699 -11.102  1.00 57.34           C  
ATOM     71  O2'   G B 404      -0.731  80.853 -12.501  1.00 56.82           O  
ATOM     72  C1'   G B 404      -1.957  81.011 -10.414  1.00 58.91           C  
ATOM     73  N9    G B 404      -1.723  81.548  -9.077  1.00 62.40           N  
ATOM     74  C8    G B 404      -1.617  80.877  -7.879  1.00 64.08           C  
ATOM     75  N7    G B 404      -1.330  81.665  -6.874  1.00 62.13           N  
ATOM     76  C5    G B 404      -1.263  82.926  -7.447  1.00 65.17           C  
ATOM     77  C6    G B 404      -0.974  84.198  -6.870  1.00 66.05           C  
ATOM     78  O6    G B 404      -0.720  84.480  -5.691  1.00 66.13           O  
ATOM     79  N1    G B 404      -0.996  85.201  -7.830  1.00 68.24           N  
ATOM     80  C2    G B 404      -1.263  85.007  -9.168  1.00 68.66           C  
ATOM     81  N2    G B 404      -1.220  86.088  -9.951  1.00 69.85           N  
ATOM     82  N3    G B 404      -1.541  83.846  -9.707  1.00 66.20           N  
ATOM     83  C4    G B 404      -1.520  82.860  -8.803  1.00 64.33           C  
ATOM     84  P     A B 405       2.075  78.779 -11.319  1.00 55.94           P  
ATOM     85  OP1   A B 405       2.817  77.923 -12.277  1.00 57.51           O  
ATOM     86  OP2   A B 405       2.364  78.671  -9.870  1.00 56.15           O  
ATOM     87  O5'   A B 405       2.297  80.302 -11.733  1.00 56.55           O  
ATOM     88  C5'   A B 405       2.219  80.703 -13.100  1.00 57.24           C  
ATOM     89  C4'   A B 405       2.817  82.082 -13.289  1.00 57.50           C  
ATOM     90  O4'   A B 405       1.984  83.077 -12.633  1.00 58.02           O  
ATOM     91  C3'   A B 405       4.200  82.320 -12.703  1.00 56.81           C  
ATOM     92  O3'   A B 405       5.229  81.874 -13.572  1.00 54.92           O  
ATOM     93  C2'   A B 405       4.238  83.835 -12.606  1.00 57.59           C  
ATOM     94  O2'   A B 405       4.547  84.407 -13.862  1.00 57.87           O  
ATOM     95  C1'   A B 405       2.795  84.153 -12.192  1.00 58.01           C  
ATOM     96  N9    A B 405       2.642  84.272 -10.742  1.00 59.38           N  
ATOM     97  C8    A B 405       2.018  83.403  -9.882  1.00 59.59           C  
ATOM     98  N7    A B 405       2.077  83.769  -8.624  1.00 59.39           N  
ATOM     99  C5    A B 405       2.781  84.964  -8.657  1.00 59.02           C  
ATOM    100  C6    A B 405       3.183  85.856  -7.644  1.00 58.87           C  
ATOM    101  N6    A B 405       2.931  85.670  -6.344  1.00 57.80           N  
ATOM    102  N1    A B 405       3.865  86.960  -8.017  1.00 59.39           N  
ATOM    103  C2    A B 405       4.126  87.145  -9.319  1.00 60.07           C  
ATOM    104  N3    A B 405       3.805  86.381 -10.361  1.00 60.22           N  
ATOM    105  C4    A B 405       3.127  85.292  -9.957  1.00 59.88           C  
ATOM    106  P     C B 406       6.703  81.619 -12.987  1.00 55.85           P  
ATOM    107  OP1   C B 406       7.488  80.954 -14.062  1.00 55.75           O  
ATOM    108  OP2   C B 406       6.573  80.967 -11.653  1.00 54.70           O  
ATOM    109  O5'   C B 406       7.303  83.077 -12.751  1.00 55.08           O  
ATOM    110  C5'   C B 406       7.621  83.925 -13.848  1.00 55.38           C  
ATOM    111  C4'   C B 406       8.265  85.195 -13.353  1.00 54.88           C  
ATOM    112  O4'   C B 406       7.332  85.892 -12.490  1.00 54.94           O  
ATOM    113  C3'   C B 406       9.490  84.997 -12.482  1.00 55.13           C  
ATOM    114  O3'   C B 406      10.651  84.843 -13.280  1.00 56.78           O  
ATOM    115  C2'   C B 406       9.523  86.290 -11.682  1.00 54.42           C  
ATOM    116  O2'   C B 406      10.062  87.359 -12.429  1.00 52.99           O  
ATOM    117  C1'   C B 406       8.033  86.535 -11.441  1.00 54.26           C  
ATOM    118  N1    C B 406       7.526  86.013 -10.156  1.00 55.00           N  
ATOM    119  C2    C B 406       7.423  86.888  -9.061  1.00 55.09           C  
ATOM    120  O2    C B 406       7.741  88.074  -9.207  1.00 56.00           O  
ATOM    121  N3    C B 406       6.971  86.419  -7.876  1.00 54.14           N  
ATOM    122  C4    C B 406       6.612  85.143  -7.757  1.00 54.00           C  
ATOM    123  N4    C B 406       6.167  84.735  -6.571  1.00 53.11           N  
ATOM    124  C5    C B 406       6.694  84.229  -8.854  1.00 54.31           C  
ATOM    125  C6    C B 406       7.157  84.702 -10.023  1.00 54.53           C  
ATOM    126  P     U B 407      11.926  84.078 -12.678  1.00 60.54           P  
ATOM    127  OP1   U B 407      12.966  83.984 -13.744  1.00 58.81           O  
ATOM    128  OP2   U B 407      11.459  82.839 -12.004  1.00 60.91           O  
ATOM    129  O5'   U B 407      12.437  85.069 -11.543  1.00 61.56           O  
ATOM    130  C5'   U B 407      13.003  86.324 -11.882  1.00 61.95           C  
ATOM    131  C4'   U B 407      13.328  87.116 -10.639  1.00 62.83           C  
ATOM    132  O4'   U B 407      12.117  87.536  -9.962  1.00 63.35           O  
ATOM    133  C3'   U B 407      14.061  86.396  -9.528  1.00 62.75           C  
ATOM    134  O3'   U B 407      15.433  86.213  -9.809  1.00 64.04           O  
ATOM    135  C2'   U B 407      13.867  87.355  -8.363  1.00 63.12           C  
ATOM    136  O2'   U B 407      14.780  88.436  -8.383  1.00 62.47           O  
ATOM    137  C1'   U B 407      12.438  87.849  -8.613  1.00 63.72           C  
ATOM    138  N1    U B 407      11.486  87.188  -7.711  1.00 64.14           N  
ATOM    139  C2    U B 407      11.207  87.832  -6.525  1.00 63.92           C  
ATOM    140  O2    U B 407      11.649  88.934  -6.259  1.00 63.47           O  
ATOM    141  N3    U B 407      10.391  87.144  -5.667  1.00 63.80           N  
ATOM    142  C4    U B 407       9.827  85.913  -5.875  1.00 63.35           C  
ATOM    143  O4    U B 407       9.202  85.381  -4.962  1.00 64.27           O  
ATOM    144  C5    U B 407      10.123  85.327  -7.145  1.00 63.76           C  
ATOM    145  C6    U B 407      10.923  85.971  -8.001  1.00 64.12           C  
ATOM    146  P    DC B 408      16.107  84.799  -9.480  1.00 64.95           P  
ATOM    147  OP1  DC B 408      15.983  84.556  -8.017  1.00 64.12           O  
ATOM    148  OP2  DC B 408      17.441  84.739 -10.121  1.00 65.25           O  
ATOM    149  O5'  DC B 408      15.154  83.785 -10.248  1.00 64.56           O  
ATOM    150  C5'  DC B 408      15.658  82.558 -10.726  1.00 65.60           C  
ATOM    151  C4'  DC B 408      14.952  81.419 -10.040  1.00 65.89           C  
ATOM    152  O4'  DC B 408      14.054  80.811 -10.996  1.00 67.84           O  
ATOM    153  C3'  DC B 408      15.917  80.327  -9.603  1.00 65.09           C  
ATOM    154  O3'  DC B 408      15.532  79.741  -8.370  1.00 62.90           O  
ATOM    155  C2'  DC B 408      15.860  79.310 -10.719  1.00 66.80           C  
ATOM    156  C1'  DC B 408      14.472  79.492 -11.310  1.00 69.24           C  
ATOM    157  N1   DC B 408      14.506  79.368 -12.773  1.00 72.14           N  
ATOM    158  C2   DC B 408      13.481  78.682 -13.422  1.00 73.96           C  
ATOM    159  O2   DC B 408      12.518  78.266 -12.754  1.00 75.97           O  
ATOM    160  N3   DC B 408      13.560  78.494 -14.760  1.00 74.68           N  
ATOM    161  C4   DC B 408      14.600  78.978 -15.440  1.00 74.79           C  
ATOM    162  N4   DC B 408      14.658  78.738 -16.748  1.00 76.70           N  
ATOM    163  C5   DC B 408      15.633  79.721 -14.807  1.00 74.63           C  
ATOM    164  C6   DC B 408      15.547  79.892 -13.486  1.00 72.92           C  
ATOM    165  P    DT B 409      16.559  78.763  -7.629  1.00 62.00           P  
ATOM    166  OP1  DT B 409      16.090  78.541  -6.237  1.00 62.03           O  
ATOM    167  OP2  DT B 409      17.920  79.307  -7.872  1.00 61.36           O  
ATOM    168  O5'  DT B 409      16.433  77.396  -8.436  1.00 62.02           O  
ATOM    169  C5'  DT B 409      15.236  76.636  -8.388  1.00 61.25           C  
ATOM    170  C4'  DT B 409      15.366  75.401  -9.246  1.00 61.31           C  
ATOM    171  O4'  DT B 409      15.219  75.742 -10.638  1.00 61.88           O  
ATOM    172  C3'  DT B 409      16.699  74.665  -9.125  1.00 61.22           C  
ATOM    173  O3'  DT B 409      16.715  73.523  -8.289  1.00 62.04           O  
ATOM    174  C2'  DT B 409      17.185  74.487 -10.552  1.00 61.70           C  
ATOM    175  C1'  DT B 409      15.986  74.841 -11.410  1.00 63.20           C  
ATOM    176  N1   DT B 409      16.377  75.534 -12.648  1.00 65.78           N  
ATOM    177  C2   DT B 409      15.788  75.156 -13.831  1.00 67.19           C  
ATOM    178  O2   DT B 409      14.903  74.317 -13.901  1.00 68.23           O  
ATOM    179  N3   DT B 409      16.271  75.805 -14.937  1.00 69.70           N  
ATOM    180  C4   DT B 409      17.252  76.784 -14.971  1.00 69.94           C  
ATOM    181  O4   DT B 409      17.610  77.261 -16.045  1.00 70.40           O  
ATOM    182  C5   DT B 409      17.788  77.161 -13.689  1.00 68.73           C  
ATOM    183  C7   DT B 409      18.820  78.239 -13.619  1.00 69.74           C  
ATOM    184  C6   DT B 409      17.333  76.525 -12.609  1.00 67.11           C  
TER     185       DT B 409                                                      
ATOM    186  N   MET A 224       3.450  78.390  11.822  1.00 52.38           N  
ATOM    187  CA  MET A 224       4.858  78.157  11.383  1.00 52.59           C  
ATOM    188  C   MET A 224       4.920  77.164  10.215  1.00 52.94           C  
ATOM    189  O   MET A 224       4.019  76.332  10.032  1.00 54.96           O  
ATOM    190  CB  MET A 224       5.690  77.626  12.556  1.00 50.91           C  
ATOM    191  N   ALA A 225       5.983  77.259   9.422  1.00 50.40           N  
ATOM    192  CA  ALA A 225       6.169  76.366   8.286  1.00 48.00           C  
ATOM    193  C   ALA A 225       6.946  75.124   8.734  1.00 47.11           C  
ATOM    194  O   ALA A 225       7.903  75.222   9.501  1.00 48.50           O  
ATOM    195  CB  ALA A 225       6.923  77.087   7.180  1.00 47.45           C  
ATOM    196  N   GLN A 226       6.531  73.955   8.259  1.00 44.10           N  
ATOM    197  CA  GLN A 226       7.199  72.708   8.623  1.00 40.99           C  
ATOM    198  C   GLN A 226       8.122  72.261   7.493  1.00 37.33           C  
ATOM    199  O   GLN A 226       7.715  72.256   6.336  1.00 37.18           O  
ATOM    200  CB  GLN A 226       6.149  71.627   8.908  1.00 40.68           C  
ATOM    201  CG  GLN A 226       6.704  70.224   9.048  1.00 43.58           C  
ATOM    202  CD  GLN A 226       5.606  69.160   9.143  1.00 45.62           C  
ATOM    203  OE1 GLN A 226       4.650  69.157   8.359  1.00 47.26           O  
ATOM    204  NE2 GLN A 226       5.751  68.247  10.095  1.00 45.40           N  
ATOM    205  N   PRO A 227       9.386  71.913   7.811  1.00 35.16           N  
ATOM    206  CA  PRO A 227      10.365  71.459   6.803  1.00 32.80           C  
ATOM    207  C   PRO A 227       9.787  70.235   6.100  1.00 31.10           C  
ATOM    208  O   PRO A 227       9.205  69.371   6.759  1.00 27.12           O  
ATOM    209  CB  PRO A 227      11.588  71.100   7.639  1.00 32.44           C  
ATOM    210  CG  PRO A 227      11.468  72.022   8.826  1.00 32.88           C  
ATOM    211  CD  PRO A 227       9.995  71.954   9.151  1.00 32.92           C  
ATOM    212  N   VAL A 228       9.926  70.145   4.780  1.00 30.03           N  
ATOM    213  CA  VAL A 228       9.337  68.997   4.122  1.00 31.96           C  
ATOM    214  C   VAL A 228      10.081  67.737   4.497  1.00 32.86           C  
ATOM    215  O   VAL A 228       9.521  66.640   4.402  1.00 33.50           O  
ATOM    216  CB  VAL A 228       9.242  69.154   2.565  1.00 32.17           C  
ATOM    217  CG1 VAL A 228       9.214  70.614   2.199  1.00 34.34           C  
ATOM    218  CG2 VAL A 228      10.341  68.406   1.862  1.00 30.53           C  
ATOM    219  N   ILE A 229      11.331  67.886   4.939  1.00 33.20           N  
ATOM    220  CA  ILE A 229      12.100  66.722   5.354  1.00 34.92           C  
ATOM    221  C   ILE A 229      11.390  66.086   6.543  1.00 36.35           C  
ATOM    222  O   ILE A 229      11.195  64.875   6.576  1.00 38.30           O  
ATOM    223  CB  ILE A 229      13.534  67.083   5.770  1.00 35.52           C  
ATOM    224  CG1 ILE A 229      14.363  67.454   4.540  1.00 36.34           C  
ATOM    225  CG2 ILE A 229      14.179  65.889   6.466  1.00 32.23           C  
ATOM    226  CD1 ILE A 229      14.798  66.248   3.711  1.00 38.17           C  
ATOM    227  N   GLU A 230      11.006  66.907   7.516  1.00 37.53           N  
ATOM    228  CA  GLU A 230      10.293  66.425   8.700  1.00 39.85           C  
ATOM    229  C   GLU A 230       8.928  65.847   8.335  1.00 39.61           C  
ATOM    230  O   GLU A 230       8.485  64.856   8.925  1.00 41.29           O  
ATOM    231  CB  GLU A 230      10.071  67.559   9.698  1.00 41.84           C  
ATOM    232  CG  GLU A 230      11.245  67.885  10.582  1.00 46.38           C  
ATOM    233  CD  GLU A 230      10.911  68.994  11.566  1.00 51.38           C  
ATOM    234  OE1 GLU A 230       9.770  68.988  12.107  1.00 54.04           O  
ATOM    235  OE2 GLU A 230      11.784  69.862  11.803  1.00 50.78           O  
ATOM    236  N   PHE A 231       8.252  66.486   7.384  1.00 37.57           N  
ATOM    237  CA  PHE A 231       6.941  66.029   6.949  1.00 36.65           C  
ATOM    238  C   PHE A 231       7.114  64.627   6.357  1.00 37.36           C  
ATOM    239  O   PHE A 231       6.328  63.713   6.638  1.00 36.35           O  
ATOM    240  CB  PHE A 231       6.365  66.994   5.908  1.00 34.48           C  
ATOM    241  CG  PHE A 231       5.053  66.549   5.331  1.00 33.71           C  
ATOM    242  CD1 PHE A 231       3.896  66.563   6.101  1.00 34.73           C  
ATOM    243  CD2 PHE A 231       4.969  66.119   4.012  1.00 32.23           C  
ATOM    244  CE1 PHE A 231       2.660  66.154   5.559  1.00 32.92           C  
ATOM    245  CE2 PHE A 231       3.752  65.710   3.465  1.00 31.09           C  
ATOM    246  CZ  PHE A 231       2.596  65.729   4.240  1.00 30.70           C  
ATOM    247  N   MET A 232       8.154  64.472   5.541  1.00 36.36           N  
ATOM    248  CA  MET A 232       8.470  63.198   4.925  1.00 36.15           C  
ATOM    249  C   MET A 232       8.690  62.134   5.999  1.00 37.14           C  
ATOM    250  O   MET A 232       8.030  61.094   6.016  1.00 39.46           O  
ATOM    251  CB  MET A 232       9.743  63.320   4.095  1.00 35.37           C  
ATOM    252  CG  MET A 232      10.223  61.985   3.553  1.00 38.18           C  
ATOM    253  SD  MET A 232      11.949  61.986   3.051  1.00 36.65           S  
ATOM    254  CE  MET A 232      11.751  62.194   1.356  1.00 40.66           C  
ATOM    255  N   CYS A 233       9.630  62.389   6.896  1.00 36.87           N  
ATOM    256  CA  CYS A 233       9.917  61.428   7.939  1.00 38.58           C  
ATOM    257  C   CYS A 233       8.629  61.005   8.643  1.00 39.51           C  
ATOM    258  O   CYS A 233       8.454  59.840   9.009  1.00 39.08           O  
ATOM    259  CB  CYS A 233      10.930  62.014   8.930  1.00 39.52           C  
ATOM    260  SG  CYS A 233      12.628  62.154   8.254  1.00 39.09           S  
ATOM    261  N   GLU A 234       7.715  61.946   8.821  1.00 40.02           N  
ATOM    262  CA  GLU A 234       6.456  61.623   9.471  1.00 41.18           C  
ATOM    263  C   GLU A 234       5.605  60.721   8.602  1.00 41.42           C  
ATOM    264  O   GLU A 234       4.964  59.790   9.098  1.00 41.31           O  
ATOM    265  CB  GLU A 234       5.672  62.887   9.779  1.00 43.27           C  
ATOM    266  CG  GLU A 234       6.110  63.599  11.029  1.00 47.38           C  
ATOM    267  CD  GLU A 234       5.251  64.804  11.287  1.00 49.81           C  
ATOM    268  OE1 GLU A 234       5.398  65.434  12.359  1.00 50.55           O  
ATOM    269  OE2 GLU A 234       4.424  65.113  10.401  1.00 49.97           O  
ATOM    270  N   VAL A 235       5.587  61.007   7.303  1.00 40.88           N  
ATOM    271  CA  VAL A 235       4.800  60.212   6.378  1.00 39.94           C  
ATOM    272  C   VAL A 235       5.355  58.792   6.275  1.00 41.16           C  
ATOM    273  O   VAL A 235       4.602  57.824   6.334  1.00 40.57           O  
ATOM    274  CB  VAL A 235       4.761  60.872   4.981  1.00 38.98           C  
ATOM    275  CG1 VAL A 235       4.030  59.965   3.979  1.00 37.30           C  
ATOM    276  CG2 VAL A 235       4.063  62.223   5.078  1.00 34.82           C  
ATOM    277  N   LEU A 236       6.675  58.670   6.158  1.00 43.03           N  
ATOM    278  CA  LEU A 236       7.320  57.362   6.032  1.00 44.18           C  
ATOM    279  C   LEU A 236       7.657  56.672   7.359  1.00 46.99           C  
ATOM    280  O   LEU A 236       8.247  55.586   7.364  1.00 46.39           O  
ATOM    281  CB  LEU A 236       8.593  57.509   5.212  1.00 41.70           C  
ATOM    282  CG  LEU A 236       8.395  58.103   3.819  1.00 41.15           C  
ATOM    283  CD1 LEU A 236       9.752  58.272   3.184  1.00 42.04           C  
ATOM    284  CD2 LEU A 236       7.504  57.211   2.965  1.00 38.51           C  
ATOM    285  N   ASP A 237       7.275  57.300   8.470  1.00 48.83           N  
ATOM    286  CA  ASP A 237       7.542  56.774   9.802  1.00 52.87           C  
ATOM    287  C   ASP A 237       9.034  56.596  10.086  1.00 55.31           C  
ATOM    288  O   ASP A 237       9.481  55.516  10.457  1.00 55.62           O  
ATOM    289  CB  ASP A 237       6.809  55.450  10.007  1.00 54.58           C  
ATOM    290  CG  ASP A 237       5.328  55.641  10.275  1.00 57.38           C  
ATOM    291  OD1 ASP A 237       4.568  54.649  10.209  1.00 58.01           O  
ATOM    292  OD2 ASP A 237       4.924  56.788  10.564  1.00 59.76           O  
ATOM    293  N   ILE A 238       9.799  57.667   9.906  1.00 58.11           N  
ATOM    294  CA  ILE A 238      11.235  57.639  10.158  1.00 61.54           C  
ATOM    295  C   ILE A 238      11.549  58.567  11.326  1.00 65.30           C  
ATOM    296  O   ILE A 238      10.852  59.561  11.537  1.00 65.49           O  
ATOM    297  CB  ILE A 238      12.045  58.145   8.942  1.00 60.01           C  
ATOM    298  CG1 ILE A 238      11.742  57.303   7.709  1.00 58.58           C  
ATOM    299  CG2 ILE A 238      13.525  58.078   9.241  1.00 58.16           C  
ATOM    300  CD1 ILE A 238      12.504  57.741   6.487  1.00 56.13           C  
ATOM    301  N   ARG A 239      12.590  58.236  12.085  1.00 69.89           N  
ATOM    302  CA  ARG A 239      13.018  59.065  13.211  1.00 74.71           C  
ATOM    303  C   ARG A 239      14.523  59.267  13.090  1.00 76.52           C  
ATOM    304  O   ARG A 239      15.075  60.266  13.548  1.00 76.84           O  
ATOM    305  CB  ARG A 239      12.706  58.386  14.554  1.00 76.15           C  
ATOM    306  CG  ARG A 239      11.233  58.115  14.811  1.00 78.93           C  
ATOM    307  CD  ARG A 239      10.979  57.680  16.259  1.00 81.78           C  
ATOM    308  NE  ARG A 239       9.597  57.236  16.457  1.00 84.06           N  
ATOM    309  CZ  ARG A 239       9.026  57.024  17.641  1.00 83.56           C  
ATOM    310  NH1 ARG A 239       9.710  57.214  18.760  1.00 83.45           N  
ATOM    311  NH2 ARG A 239       7.762  56.622  17.704  1.00 82.75           N  
ATOM    312  N   ASN A 240      15.164  58.305  12.438  1.00 79.88           N  
ATOM    313  CA  ASN A 240      16.611  58.283  12.238  1.00 82.09           C  
ATOM    314  C   ASN A 240      17.042  58.699  10.832  1.00 82.28           C  
ATOM    315  O   ASN A 240      17.943  58.087  10.251  1.00 81.15           O  
ATOM    316  CB  ASN A 240      17.120  56.866  12.511  1.00 84.41           C  
ATOM    317  CG  ASN A 240      16.458  55.822  11.607  1.00 85.46           C  
ATOM    318  OD1 ASN A 240      15.231  55.670  11.602  1.00 85.25           O  
ATOM    319  ND2 ASN A 240      17.271  55.103  10.838  1.00 85.27           N  
ATOM    320  N   ILE A 241      16.413  59.733  10.283  1.00 82.81           N  
ATOM    321  CA  ILE A 241      16.763  60.170   8.939  1.00 83.45           C  
ATOM    322  C   ILE A 241      18.261  60.409   8.813  1.00 84.72           C  
ATOM    323  O   ILE A 241      18.835  60.264   7.734  1.00 85.15           O  
ATOM    324  CB  ILE A 241      16.017  61.458   8.546  1.00 82.67           C  
ATOM    325  CG1 ILE A 241      16.366  61.824   7.103  1.00 81.66           C  
ATOM    326  CG2 ILE A 241      16.375  62.586   9.503  1.00 82.24           C  
ATOM    327  CD1 ILE A 241      15.618  63.007   6.578  1.00 82.39           C  
ATOM    328  N   ASP A 242      18.890  60.762   9.928  1.00 86.29           N  
ATOM    329  CA  ASP A 242      20.323  61.026   9.949  1.00 87.25           C  
ATOM    330  C   ASP A 242      21.117  59.831  10.453  1.00 86.99           C  
ATOM    331  O   ASP A 242      22.168  59.986  11.070  1.00 86.30           O  
ATOM    332  CB  ASP A 242      20.605  62.248  10.821  1.00 88.44           C  
ATOM    333  CG  ASP A 242      20.160  63.538  10.166  1.00 89.82           C  
ATOM    334  OD1 ASP A 242      20.008  64.552  10.881  1.00 90.72           O  
ATOM    335  OD2 ASP A 242      19.973  63.540   8.929  1.00 90.52           O  
ATOM    336  N   GLU A 243      20.605  58.638  10.182  1.00 87.05           N  
ATOM    337  CA  GLU A 243      21.260  57.409  10.603  1.00 87.22           C  
ATOM    338  C   GLU A 243      21.271  56.496   9.386  1.00 86.78           C  
ATOM    339  O   GLU A 243      22.179  55.686   9.195  1.00 86.45           O  
ATOM    340  CB  GLU A 243      20.472  56.778  11.751  1.00 88.04           C  
ATOM    341  CG  GLU A 243      21.196  55.676  12.501  1.00 90.84           C  
ATOM    342  CD  GLU A 243      20.436  55.225  13.743  1.00 93.05           C  
ATOM    343  OE1 GLU A 243      19.292  54.737  13.601  1.00 93.97           O  
ATOM    344  OE2 GLU A 243      20.982  55.362  14.863  1.00 93.68           O  
ATOM    345  N   GLN A 244      20.245  56.659   8.558  1.00 86.41           N  
ATOM    346  CA  GLN A 244      20.091  55.887   7.336  1.00 84.76           C  
ATOM    347  C   GLN A 244      20.263  56.776   6.117  1.00 83.00           C  
ATOM    348  O   GLN A 244      19.279  57.232   5.528  1.00 83.36           O  
ATOM    349  CB  GLN A 244      18.706  55.247   7.267  1.00 86.16           C  
ATOM    350  CG  GLN A 244      18.539  53.962   8.051  1.00 88.16           C  
ATOM    351  CD  GLN A 244      17.171  53.343   7.822  1.00 88.79           C  
ATOM    352  OE1 GLN A 244      16.758  53.135   6.680  1.00 88.89           O  
ATOM    353  NE2 GLN A 244      16.460  53.047   8.907  1.00 89.30           N  
ATOM    354  N   PRO A 245      21.515  57.058   5.733  1.00 80.90           N  
ATOM    355  CA  PRO A 245      21.736  57.904   4.555  1.00 78.97           C  
ATOM    356  C   PRO A 245      21.327  57.121   3.299  1.00 76.61           C  
ATOM    357  O   PRO A 245      21.853  57.342   2.205  1.00 76.48           O  
ATOM    358  CB  PRO A 245      23.237  58.184   4.608  1.00 79.18           C  
ATOM    359  CG  PRO A 245      23.538  58.121   6.084  1.00 79.96           C  
ATOM    360  CD  PRO A 245      22.756  56.905   6.511  1.00 80.00           C  
ATOM    361  N   LYS A 246      20.382  56.202   3.488  1.00 73.23           N  
ATOM    362  CA  LYS A 246      19.859  55.347   2.426  1.00 68.77           C  
ATOM    363  C   LYS A 246      18.830  56.088   1.584  1.00 64.22           C  
ATOM    364  O   LYS A 246      18.050  56.889   2.099  1.00 62.98           O  
ATOM    365  CB  LYS A 246      19.186  54.111   3.033  1.00 70.46           C  
ATOM    366  CG  LYS A 246      19.981  53.417   4.135  1.00 72.30           C  
ATOM    367  CD  LYS A 246      19.178  52.270   4.750  1.00 73.74           C  
ATOM    368  CE  LYS A 246      19.955  51.576   5.872  1.00 75.11           C  
ATOM    369  NZ  LYS A 246      19.227  50.401   6.445  1.00 73.49           N  
ATOM    370  N   PRO A 247      18.814  55.829   0.270  1.00 60.77           N  
ATOM    371  CA  PRO A 247      17.836  56.511  -0.575  1.00 57.60           C  
ATOM    372  C   PRO A 247      16.453  55.982  -0.205  1.00 55.28           C  
ATOM    373  O   PRO A 247      16.310  55.164   0.705  1.00 55.92           O  
ATOM    374  CB  PRO A 247      18.242  56.091  -1.986  1.00 57.61           C  
ATOM    375  CG  PRO A 247      19.690  55.765  -1.858  1.00 58.03           C  
ATOM    376  CD  PRO A 247      19.742  55.034  -0.549  1.00 59.36           C  
ATOM    377  N   LEU A 248      15.434  56.445  -0.912  1.00 51.83           N  
ATOM    378  CA  LEU A 248      14.084  55.988  -0.648  1.00 47.06           C  
ATOM    379  C   LEU A 248      13.709  54.767  -1.499  1.00 45.36           C  
ATOM    380  O   LEU A 248      14.164  54.616  -2.638  1.00 43.17           O  
ATOM    381  CB  LEU A 248      13.091  57.119  -0.916  1.00 43.07           C  
ATOM    382  CG  LEU A 248      13.067  58.260   0.097  1.00 42.14           C  
ATOM    383  CD1 LEU A 248      12.003  59.288  -0.313  1.00 40.10           C  
ATOM    384  CD2 LEU A 248      12.771  57.706   1.479  1.00 37.81           C  
ATOM    385  N   THR A 249      12.891  53.889  -0.932  1.00 43.18           N  
ATOM    386  CA  THR A 249      12.429  52.725  -1.671  1.00 43.01           C  
ATOM    387  C   THR A 249      11.366  53.250  -2.641  1.00 42.41           C  
ATOM    388  O   THR A 249      10.854  54.360  -2.461  1.00 41.63           O  
ATOM    389  CB  THR A 249      11.782  51.677  -0.734  1.00 43.99           C  
ATOM    390  OG1 THR A 249      10.566  52.203  -0.181  1.00 43.31           O  
ATOM    391  CG2 THR A 249      12.726  51.324   0.407  1.00 43.10           C  
ATOM    392  N   ASP A 250      11.039  52.472  -3.667  1.00 41.87           N  
ATOM    393  CA  ASP A 250      10.024  52.895  -4.626  1.00 41.52           C  
ATOM    394  C   ASP A 250       8.710  53.007  -3.884  1.00 39.85           C  
ATOM    395  O   ASP A 250       7.870  53.873  -4.170  1.00 39.07           O  
ATOM    396  CB  ASP A 250       9.909  51.884  -5.756  1.00 43.78           C  
ATOM    397  CG  ASP A 250      11.156  51.841  -6.615  1.00 48.32           C  
ATOM    398  OD1 ASP A 250      11.410  52.841  -7.326  1.00 48.21           O  
ATOM    399  OD2 ASP A 250      11.887  50.821  -6.566  1.00 49.56           O  
ATOM    400  N   SER A 251       8.566  52.136  -2.897  1.00 37.14           N  
ATOM    401  CA  SER A 251       7.388  52.097  -2.064  1.00 35.28           C  
ATOM    402  C   SER A 251       7.316  53.394  -1.257  1.00 35.70           C  
ATOM    403  O   SER A 251       6.273  54.050  -1.190  1.00 36.45           O  
ATOM    404  CB  SER A 251       7.490  50.888  -1.142  1.00 35.23           C  
ATOM    405  OG  SER A 251       6.333  50.710  -0.366  1.00 34.72           O  
ATOM    406  N   GLN A 252       8.438  53.776  -0.662  1.00 36.07           N  
ATOM    407  CA  GLN A 252       8.490  54.990   0.145  1.00 36.43           C  
ATOM    408  C   GLN A 252       8.258  56.258  -0.671  1.00 35.84           C  
ATOM    409  O   GLN A 252       7.553  57.166  -0.230  1.00 35.49           O  
ATOM    410  CB  GLN A 252       9.831  55.079   0.865  1.00 37.68           C  
ATOM    411  CG  GLN A 252      10.061  53.958   1.861  1.00 40.46           C  
ATOM    412  CD  GLN A 252      11.467  53.971   2.455  1.00 42.15           C  
ATOM    413  OE1 GLN A 252      12.475  53.882   1.732  1.00 39.89           O  
ATOM    414  NE2 GLN A 252      11.540  54.083   3.781  1.00 40.50           N  
ATOM    415  N   ARG A 253       8.855  56.318  -1.856  1.00 35.21           N  
ATOM    416  CA  ARG A 253       8.705  57.479  -2.720  1.00 34.65           C  
ATOM    417  C   ARG A 253       7.249  57.648  -3.108  1.00 36.54           C  
ATOM    418  O   ARG A 253       6.720  58.759  -3.062  1.00 36.61           O  
ATOM    419  CB  ARG A 253       9.565  57.324  -3.977  1.00 34.72           C  
ATOM    420  CG  ARG A 253       9.366  58.415  -5.021  1.00 35.92           C  
ATOM    421  CD  ARG A 253      10.397  58.308  -6.143  1.00 35.57           C  
ATOM    422  NE  ARG A 253      10.547  56.932  -6.593  1.00 36.80           N  
ATOM    423  CZ  ARG A 253       9.596  56.240  -7.209  1.00 38.77           C  
ATOM    424  NH1 ARG A 253       9.820  54.982  -7.572  1.00 38.11           N  
ATOM    425  NH2 ARG A 253       8.427  56.812  -7.474  1.00 38.54           N  
ATOM    426  N   VAL A 254       6.601  56.546  -3.490  1.00 37.64           N  
ATOM    427  CA  VAL A 254       5.190  56.587  -3.878  1.00 37.26           C  
ATOM    428  C   VAL A 254       4.316  57.039  -2.713  1.00 38.17           C  
ATOM    429  O   VAL A 254       3.360  57.798  -2.907  1.00 38.65           O  
ATOM    430  CB  VAL A 254       4.681  55.208  -4.371  1.00 36.43           C  
ATOM    431  CG1 VAL A 254       3.160  55.187  -4.361  1.00 34.13           C  
ATOM    432  CG2 VAL A 254       5.184  54.941  -5.790  1.00 33.45           C  
ATOM    433  N   ARG A 255       4.635  56.575  -1.507  1.00 37.96           N  
ATOM    434  CA  ARG A 255       3.859  56.963  -0.331  1.00 36.76           C  
ATOM    435  C   ARG A 255       4.075  58.431   0.007  1.00 34.69           C  
ATOM    436  O   ARG A 255       3.146  59.126   0.425  1.00 36.25           O  
ATOM    437  CB  ARG A 255       4.235  56.108   0.872  1.00 38.30           C  
ATOM    438  CG  ARG A 255       3.358  54.890   1.062  1.00 43.22           C  
ATOM    439  CD  ARG A 255       3.742  54.163   2.336  1.00 44.70           C  
ATOM    440  NE  ARG A 255       5.003  53.454   2.171  1.00 47.64           N  
ATOM    441  CZ  ARG A 255       5.895  53.290   3.138  1.00 48.16           C  
ATOM    442  NH1 ARG A 255       5.654  53.798   4.342  1.00 48.07           N  
ATOM    443  NH2 ARG A 255       7.016  52.614   2.900  1.00 46.39           N  
ATOM    444  N   PHE A 256       5.302  58.900  -0.169  1.00 29.28           N  
ATOM    445  CA  PHE A 256       5.612  60.286   0.116  1.00 27.29           C  
ATOM    446  C   PHE A 256       4.989  61.209  -0.947  1.00 27.59           C  
ATOM    447  O   PHE A 256       4.413  62.245  -0.612  1.00 28.06           O  
ATOM    448  CB  PHE A 256       7.129  60.468   0.156  1.00 25.39           C  
ATOM    449  CG  PHE A 256       7.572  61.897   0.290  1.00 24.47           C  
ATOM    450  CD1 PHE A 256       8.508  62.432  -0.589  1.00 24.94           C  
ATOM    451  CD2 PHE A 256       7.073  62.706   1.302  1.00 22.67           C  
ATOM    452  CE1 PHE A 256       8.934  63.753  -0.449  1.00 25.93           C  
ATOM    453  CE2 PHE A 256       7.499  64.023   1.441  1.00 19.72           C  
ATOM    454  CZ  PHE A 256       8.421  64.542   0.575  1.00 20.32           C  
ATOM    455  N   THR A 257       5.102  60.825  -2.218  1.00 25.59           N  
ATOM    456  CA  THR A 257       4.566  61.619  -3.317  1.00 26.20           C  
ATOM    457  C   THR A 257       3.087  61.929  -3.150  1.00 29.13           C  
ATOM    458  O   THR A 257       2.664  63.072  -3.335  1.00 30.70           O  
ATOM    459  CB  THR A 257       4.756  60.912  -4.669  1.00 24.74           C  
ATOM    460  OG1 THR A 257       6.148  60.652  -4.887  1.00 23.79           O  
ATOM    461  CG2 THR A 257       4.243  61.780  -5.790  1.00 22.13           C  
ATOM    462  N   LYS A 258       2.305  60.912  -2.803  1.00 30.52           N  
ATOM    463  CA  LYS A 258       0.868  61.078  -2.606  1.00 32.09           C  
ATOM    464  C   LYS A 258       0.524  62.184  -1.634  1.00 32.38           C  
ATOM    465  O   LYS A 258      -0.474  62.882  -1.807  1.00 33.55           O  
ATOM    466  CB  LYS A 258       0.241  59.788  -2.078  1.00 33.10           C  
ATOM    467  CG  LYS A 258      -0.118  58.785  -3.148  1.00 35.45           C  
ATOM    468  CD  LYS A 258      -0.654  57.508  -2.511  1.00 39.57           C  
ATOM    469  CE  LYS A 258      -1.018  56.471  -3.555  1.00 38.42           C  
ATOM    470  NZ  LYS A 258      -1.398  55.185  -2.914  1.00 40.54           N  
ATOM    471  N   GLU A 259       1.355  62.334  -0.610  1.00 32.40           N  
ATOM    472  CA  GLU A 259       1.128  63.326   0.428  1.00 32.18           C  
ATOM    473  C   GLU A 259       1.618  64.720   0.107  1.00 31.65           C  
ATOM    474  O   GLU A 259       0.996  65.703   0.491  1.00 30.84           O  
ATOM    475  CB  GLU A 259       1.784  62.860   1.724  1.00 33.15           C  
ATOM    476  CG  GLU A 259       1.350  61.485   2.130  1.00 38.11           C  
ATOM    477  CD  GLU A 259      -0.148  61.396   2.352  1.00 41.42           C  
ATOM    478  OE1 GLU A 259      -0.710  60.286   2.219  1.00 44.27           O  
ATOM    479  OE2 GLU A 259      -0.769  62.433   2.671  1.00 45.67           O  
ATOM    480  N   ILE A 260       2.742  64.813  -0.586  1.00 31.09           N  
ATOM    481  CA  ILE A 260       3.289  66.118  -0.890  1.00 30.60           C  
ATOM    482  C   ILE A 260       2.707  66.724  -2.156  1.00 31.75           C  
ATOM    483  O   ILE A 260       2.651  67.941  -2.293  1.00 33.59           O  
ATOM    484  CB  ILE A 260       4.827  66.055  -0.985  1.00 29.45           C  
ATOM    485  CG1 ILE A 260       5.389  67.470  -1.077  1.00 28.39           C  
ATOM    486  CG2 ILE A 260       5.254  65.192  -2.150  1.00 28.77           C  
ATOM    487  CD1 ILE A 260       5.229  68.255   0.205  1.00 24.75           C  
ATOM    488  N   LYS A 261       2.261  65.879  -3.078  1.00 32.87           N  
ATOM    489  CA  LYS A 261       1.678  66.362  -4.319  1.00 32.84           C  
ATOM    490  C   LYS A 261       0.464  67.251  -4.018  1.00 32.06           C  
ATOM    491  O   LYS A 261      -0.464  66.838  -3.329  1.00 31.79           O  
ATOM    492  CB  LYS A 261       1.258  65.175  -5.184  1.00 35.86           C  
ATOM    493  CG  LYS A 261       0.970  65.531  -6.633  1.00 40.84           C  
ATOM    494  CD  LYS A 261       0.553  64.301  -7.457  1.00 45.18           C  
ATOM    495  CE  LYS A 261       1.671  63.271  -7.558  1.00 49.21           C  
ATOM    496  NZ  LYS A 261       1.312  62.104  -8.429  1.00 51.15           N  
ATOM    497  N   GLY A 262       0.481  68.482  -4.511  1.00 31.02           N  
ATOM    498  CA  GLY A 262      -0.644  69.370  -4.278  1.00 30.28           C  
ATOM    499  C   GLY A 262      -0.492  70.319  -3.104  1.00 29.73           C  
ATOM    500  O   GLY A 262      -1.270  71.257  -2.975  1.00 30.16           O  
ATOM    501  N   LEU A 263       0.476  70.070  -2.226  1.00 28.43           N  
ATOM    502  CA  LEU A 263       0.697  70.970  -1.094  1.00 27.28           C  
ATOM    503  C   LEU A 263       1.498  72.175  -1.579  1.00 26.61           C  
ATOM    504  O   LEU A 263       2.155  72.119  -2.616  1.00 26.48           O  
ATOM    505  CB  LEU A 263       1.456  70.264   0.043  1.00 23.87           C  
ATOM    506  CG  LEU A 263       0.679  69.164   0.788  1.00 24.19           C  
ATOM    507  CD1 LEU A 263       1.366  68.847   2.125  1.00 15.15           C  
ATOM    508  CD2 LEU A 263      -0.773  69.625   1.019  1.00 17.55           C  
ATOM    509  N   LYS A 264       1.422  73.272  -0.842  1.00 28.49           N  
ATOM    510  CA  LYS A 264       2.159  74.474  -1.213  1.00 29.38           C  
ATOM    511  C   LYS A 264       3.422  74.577  -0.366  1.00 28.17           C  
ATOM    512  O   LYS A 264       3.383  74.361   0.859  1.00 24.66           O  
ATOM    513  CB  LYS A 264       1.307  75.732  -1.003  1.00 31.34           C  
ATOM    514  CG  LYS A 264       2.052  77.019  -1.360  1.00 36.49           C  
ATOM    515  CD  LYS A 264       1.246  78.267  -1.029  1.00 41.39           C  
ATOM    516  CE  LYS A 264      -0.005  78.388  -1.897  1.00 43.50           C  
ATOM    517  NZ  LYS A 264      -0.694  79.704  -1.731  1.00 42.27           N  
ATOM    518  N   VAL A 265       4.536  74.907  -1.014  1.00 25.32           N  
ATOM    519  CA  VAL A 265       5.783  75.043  -0.276  1.00 26.67           C  
ATOM    520  C   VAL A 265       6.508  76.372  -0.479  1.00 28.03           C  
ATOM    521  O   VAL A 265       6.325  77.050  -1.490  1.00 28.96           O  
ATOM    522  CB  VAL A 265       6.767  73.901  -0.611  1.00 24.50           C  
ATOM    523  CG1 VAL A 265       6.166  72.587  -0.216  1.00 24.10           C  
ATOM    524  CG2 VAL A 265       7.120  73.919  -2.093  1.00 22.56           C  
ATOM    525  N   GLU A 266       7.337  76.735   0.491  1.00 29.22           N  
ATOM    526  CA  GLU A 266       8.106  77.969   0.402  1.00 32.33           C  
ATOM    527  C   GLU A 266       9.597  77.677   0.522  1.00 32.11           C  
ATOM    528  O   GLU A 266      10.041  76.935   1.399  1.00 30.98           O  
ATOM    529  CB  GLU A 266       7.691  78.963   1.494  1.00 34.23           C  
ATOM    530  CG  GLU A 266       7.777  78.398   2.907  1.00 39.59           C  
ATOM    531  CD  GLU A 266       7.638  79.474   3.975  1.00 44.10           C  
ATOM    532  OE1 GLU A 266       6.777  80.377   3.808  1.00 45.32           O  
ATOM    533  OE2 GLU A 266       8.383  79.404   4.985  1.00 43.97           O  
ATOM    534  N   VAL A 267      10.349  78.274  -0.388  1.00 33.48           N  
ATOM    535  CA  VAL A 267      11.796  78.146  -0.461  1.00 36.30           C  
ATOM    536  C   VAL A 267      12.478  78.804   0.753  1.00 37.76           C  
ATOM    537  O   VAL A 267      12.012  79.839   1.231  1.00 38.75           O  
ATOM    538  CB  VAL A 267      12.261  78.782  -1.780  1.00 36.73           C  
ATOM    539  CG1 VAL A 267      13.419  79.734  -1.543  1.00 36.39           C  
ATOM    540  CG2 VAL A 267      12.605  77.679  -2.771  1.00 37.99           C  
ATOM    541  N   THR A 268      13.569  78.212   1.252  1.00 38.55           N  
ATOM    542  CA  THR A 268      14.256  78.770   2.426  1.00 40.65           C  
ATOM    543  C   THR A 268      15.713  79.166   2.210  1.00 42.78           C  
ATOM    544  O   THR A 268      16.350  79.692   3.122  1.00 43.91           O  
ATOM    545  CB  THR A 268      14.287  77.790   3.610  1.00 41.09           C  
ATOM    546  OG1 THR A 268      15.226  76.742   3.332  1.00 41.89           O  
ATOM    547  CG2 THR A 268      12.909  77.203   3.873  1.00 41.27           C  
ATOM    548  N   HIS A 269      16.240  78.913   1.016  1.00 43.11           N  
ATOM    549  CA  HIS A 269      17.628  79.215   0.716  1.00 42.38           C  
ATOM    550  C   HIS A 269      17.883  80.610   0.154  1.00 43.85           C  
ATOM    551  O   HIS A 269      19.006  80.920  -0.242  1.00 43.19           O  
ATOM    552  CB  HIS A 269      18.161  78.179  -0.270  1.00 43.97           C  
ATOM    553  CG  HIS A 269      17.517  78.249  -1.618  1.00 42.84           C  
ATOM    554  ND1 HIS A 269      16.176  77.999  -1.813  1.00 42.27           N  
ATOM    555  CD2 HIS A 269      18.019  78.586  -2.829  1.00 42.38           C  
ATOM    556  CE1 HIS A 269      15.879  78.182  -3.088  1.00 43.29           C  
ATOM    557  NE2 HIS A 269      16.979  78.539  -3.726  1.00 42.96           N  
ATOM    558  N   CYS A 270      16.859  81.453   0.115  1.00 43.93           N  
ATOM    559  CA  CYS A 270      17.030  82.791  -0.430  1.00 44.15           C  
ATOM    560  C   CYS A 270      16.756  83.900   0.558  1.00 44.77           C  
ATOM    561  O   CYS A 270      16.370  84.996   0.172  1.00 45.09           O  
ATOM    562  CB  CYS A 270      16.135  82.968  -1.641  1.00 44.22           C  
ATOM    563  SG  CYS A 270      16.496  81.766  -2.895  1.00 49.20           S  
ATOM    564  N   GLY A 271      16.965  83.615   1.833  1.00 46.55           N  
ATOM    565  CA  GLY A 271      16.726  84.615   2.850  1.00 47.98           C  
ATOM    566  C   GLY A 271      15.252  84.923   3.036  1.00 49.54           C  
ATOM    567  O   GLY A 271      14.452  84.050   3.394  1.00 50.66           O  
ATOM    568  N   GLN A 272      14.892  86.177   2.790  1.00 49.67           N  
ATOM    569  CA  GLN A 272      13.520  86.613   2.944  1.00 49.68           C  
ATOM    570  C   GLN A 272      12.728  86.540   1.647  1.00 47.75           C  
ATOM    571  O   GLN A 272      11.550  86.915   1.596  1.00 46.39           O  
ATOM    572  CB  GLN A 272      13.495  88.026   3.519  1.00 53.12           C  
ATOM    573  CG  GLN A 272      13.728  88.056   5.019  1.00 56.51           C  
ATOM    574  CD  GLN A 272      12.610  87.366   5.793  1.00 58.69           C  
ATOM    575  OE1 GLN A 272      11.463  87.835   5.810  1.00 57.15           O  
ATOM    576  NE2 GLN A 272      12.939  86.240   6.435  1.00 59.73           N  
ATOM    577  N   MET A 273      13.380  86.068   0.595  1.00 44.89           N  
ATOM    578  CA  MET A 273      12.694  85.915  -0.672  1.00 45.87           C  
ATOM    579  C   MET A 273      12.128  84.491  -0.624  1.00 45.29           C  
ATOM    580  O   MET A 273      12.636  83.580  -1.285  1.00 44.54           O  
ATOM    581  CB  MET A 273      13.669  86.059  -1.837  1.00 46.64           C  
ATOM    582  CG  MET A 273      12.976  86.094  -3.180  1.00 49.54           C  
ATOM    583  SD  MET A 273      14.108  85.785  -4.537  1.00 52.31           S  
ATOM    584  CE  MET A 273      14.918  87.400  -4.611  1.00 56.47           C  
ATOM    585  N   LYS A 274      11.087  84.307   0.185  1.00 43.03           N  
ATOM    586  CA  LYS A 274      10.466  83.000   0.353  1.00 41.85           C  
ATOM    587  C   LYS A 274       9.452  82.678  -0.739  1.00 39.43           C  
ATOM    588  O   LYS A 274       8.251  82.606  -0.490  1.00 38.71           O  
ATOM    589  CB  LYS A 274       9.800  82.926   1.723  1.00 42.33           C  
ATOM    590  CG  LYS A 274      10.762  83.108   2.865  1.00 43.62           C  
ATOM    591  CD  LYS A 274      10.036  83.029   4.189  1.00 45.77           C  
ATOM    592  CE  LYS A 274      11.002  83.142   5.346  1.00 47.03           C  
ATOM    593  NZ  LYS A 274      10.299  82.997   6.650  1.00 47.93           N  
ATOM    594  N   ARG A 275       9.953  82.476  -1.947  1.00 36.42           N  
ATOM    595  CA  ARG A 275       9.106  82.174  -3.080  1.00 35.22           C  
ATOM    596  C   ARG A 275       8.282  80.917  -2.810  1.00 36.07           C  
ATOM    597  O   ARG A 275       8.793  79.919  -2.299  1.00 34.88           O  
ATOM    598  CB  ARG A 275       9.971  81.982  -4.314  1.00 34.45           C  
ATOM    599  CG  ARG A 275       9.201  81.932  -5.599  1.00 34.01           C  
ATOM    600  CD  ARG A 275      10.160  81.865  -6.747  1.00 32.07           C  
ATOM    601  NE  ARG A 275       9.484  81.943  -8.034  1.00 32.64           N  
ATOM    602  CZ  ARG A 275      10.134  82.046  -9.186  1.00 33.30           C  
ATOM    603  NH1 ARG A 275      11.458  82.080  -9.188  1.00 32.72           N  
ATOM    604  NH2 ARG A 275       9.470  82.120 -10.332  1.00 35.23           N  
ATOM    605  N   LYS A 276       7.001  80.978  -3.155  1.00 36.59           N  
ATOM    606  CA  LYS A 276       6.093  79.865  -2.940  1.00 35.68           C  
ATOM    607  C   LYS A 276       5.868  79.064  -4.202  1.00 35.91           C  
ATOM    608  O   LYS A 276       5.763  79.620  -5.294  1.00 36.51           O  
ATOM    609  CB  LYS A 276       4.743  80.370  -2.451  1.00 36.96           C  
ATOM    610  CG  LYS A 276       4.771  81.068  -1.110  1.00 38.97           C  
ATOM    611  CD  LYS A 276       3.356  81.314  -0.624  1.00 40.10           C  
ATOM    612  CE  LYS A 276       3.358  81.898   0.767  1.00 45.29           C  
ATOM    613  NZ  LYS A 276       2.009  81.765   1.407  1.00 52.08           N  
ATOM    614  N   TYR A 277       5.791  77.750  -4.041  1.00 35.05           N  
ATOM    615  CA  TYR A 277       5.547  76.861  -5.165  1.00 34.79           C  
ATOM    616  C   TYR A 277       4.492  75.812  -4.821  1.00 34.67           C  
ATOM    617  O   TYR A 277       4.229  75.506  -3.646  1.00 35.57           O  
ATOM    618  CB  TYR A 277       6.819  76.127  -5.574  1.00 34.62           C  
ATOM    619  CG  TYR A 277       7.963  76.990  -6.022  1.00 35.57           C  
ATOM    620  CD1 TYR A 277       8.846  77.543  -5.100  1.00 35.06           C  
ATOM    621  CD2 TYR A 277       8.210  77.197  -7.384  1.00 38.06           C  
ATOM    622  CE1 TYR A 277       9.953  78.269  -5.518  1.00 35.93           C  
ATOM    623  CE2 TYR A 277       9.316  77.926  -7.819  1.00 35.69           C  
ATOM    624  CZ  TYR A 277      10.184  78.453  -6.881  1.00 37.89           C  
ATOM    625  OH  TYR A 277      11.300  79.141  -7.302  1.00 41.44           O  
ATOM    626  N   ARG A 278       3.890  75.263  -5.863  1.00 33.77           N  
ATOM    627  CA  ARG A 278       2.897  74.222  -5.702  1.00 33.18           C  
ATOM    628  C   ARG A 278       3.629  72.953  -6.083  1.00 32.50           C  
ATOM    629  O   ARG A 278       4.169  72.844  -7.180  1.00 33.59           O  
ATOM    630  CB  ARG A 278       1.727  74.436  -6.655  1.00 33.55           C  
ATOM    631  CG  ARG A 278       0.758  73.269  -6.695  1.00 34.79           C  
ATOM    632  CD  ARG A 278      -0.030  73.175  -5.395  1.00 35.47           C  
ATOM    633  NE  ARG A 278      -0.849  74.366  -5.181  1.00 33.67           N  
ATOM    634  CZ  ARG A 278      -1.453  74.661  -4.033  1.00 35.74           C  
ATOM    635  NH1 ARG A 278      -1.333  73.852  -2.987  1.00 31.40           N  
ATOM    636  NH2 ARG A 278      -2.173  75.774  -3.929  1.00 35.90           N  
ATOM    637  N   VAL A 279       3.684  72.000  -5.174  1.00 32.16           N  
ATOM    638  CA  VAL A 279       4.361  70.766  -5.484  1.00 34.20           C  
ATOM    639  C   VAL A 279       3.486  69.971  -6.440  1.00 35.66           C  
ATOM    640  O   VAL A 279       2.333  69.694  -6.131  1.00 36.67           O  
ATOM    641  CB  VAL A 279       4.592  69.941  -4.221  1.00 33.98           C  
ATOM    642  CG1 VAL A 279       5.258  68.619  -4.583  1.00 34.45           C  
ATOM    643  CG2 VAL A 279       5.442  70.726  -3.248  1.00 32.60           C  
ATOM    644  N   CYS A 280       4.010  69.616  -7.608  1.00 36.74           N  
ATOM    645  CA  CYS A 280       3.204  68.836  -8.539  1.00 37.85           C  
ATOM    646  C   CYS A 280       3.687  67.390  -8.668  1.00 37.71           C  
ATOM    647  O   CYS A 280       2.978  66.546  -9.223  1.00 38.62           O  
ATOM    648  CB  CYS A 280       3.152  69.507  -9.918  1.00 38.40           C  
ATOM    649  SG  CYS A 280       4.684  69.511 -10.847  1.00 44.08           S  
ATOM    650  N   ASN A 281       4.877  67.094  -8.147  1.00 36.33           N  
ATOM    651  CA  ASN A 281       5.394  65.729  -8.217  1.00 36.11           C  
ATOM    652  C   ASN A 281       6.705  65.551  -7.445  1.00 35.50           C  
ATOM    653  O   ASN A 281       7.262  66.521  -6.944  1.00 35.55           O  
ATOM    654  CB  ASN A 281       5.589  65.342  -9.684  1.00 35.81           C  
ATOM    655  CG  ASN A 281       5.377  63.858  -9.938  1.00 35.93           C  
ATOM    656  OD1 ASN A 281       5.307  63.428 -11.083  1.00 37.24           O  
ATOM    657  ND2 ASN A 281       5.273  63.073  -8.875  1.00 34.01           N  
ATOM    658  N   VAL A 282       7.170  64.307  -7.328  1.00 35.54           N  
ATOM    659  CA  VAL A 282       8.437  63.994  -6.657  1.00 36.69           C  
ATOM    660  C   VAL A 282       9.300  63.245  -7.667  1.00 38.42           C  
ATOM    661  O   VAL A 282       8.827  62.307  -8.315  1.00 40.36           O  
ATOM    662  CB  VAL A 282       8.253  63.087  -5.417  1.00 36.25           C  
ATOM    663  CG1 VAL A 282       9.620  62.699  -4.848  1.00 37.24           C  
ATOM    664  CG2 VAL A 282       7.457  63.806  -4.352  1.00 36.16           C  
ATOM    665  N   THR A 283      10.558  63.652  -7.811  1.00 38.96           N  
ATOM    666  CA  THR A 283      11.445  62.998  -8.773  1.00 38.61           C  
ATOM    667  C   THR A 283      11.806  61.587  -8.352  1.00 38.20           C  
ATOM    668  O   THR A 283      11.713  61.232  -7.179  1.00 39.07           O  
ATOM    669  CB  THR A 283      12.770  63.779  -8.967  1.00 40.15           C  
ATOM    670  OG1 THR A 283      13.493  63.832  -7.727  1.00 41.61           O  
ATOM    671  CG2 THR A 283      12.492  65.187  -9.454  1.00 38.95           C  
ATOM    672  N   ARG A 284      12.215  60.776  -9.316  1.00 38.54           N  
ATOM    673  CA  ARG A 284      12.623  59.411  -9.014  1.00 40.32           C  
ATOM    674  C   ARG A 284      14.110  59.413  -8.690  1.00 41.22           C  
ATOM    675  O   ARG A 284      14.575  58.626  -7.871  1.00 42.58           O  
ATOM    676  CB  ARG A 284      12.361  58.473 -10.199  1.00 39.04           C  
ATOM    677  CG  ARG A 284      10.903  58.135 -10.396  1.00 39.29           C  
ATOM    678  CD  ARG A 284      10.712  57.032 -11.418  1.00 40.14           C  
ATOM    679  NE  ARG A 284       9.298  56.709 -11.580  1.00 39.38           N  
ATOM    680  CZ  ARG A 284       8.832  55.770 -12.392  1.00 37.72           C  
ATOM    681  NH1 ARG A 284       9.666  55.048 -13.124  1.00 39.25           N  
ATOM    682  NH2 ARG A 284       7.529  55.559 -12.475  1.00 39.36           N  
ATOM    683  N   ARG A 285      14.849  60.311  -9.333  1.00 41.76           N  
ATOM    684  CA  ARG A 285      16.285  60.414  -9.125  1.00 42.14           C  
ATOM    685  C   ARG A 285      16.624  61.328  -7.949  1.00 40.66           C  
ATOM    686  O   ARG A 285      15.922  62.304  -7.686  1.00 39.32           O  
ATOM    687  CB  ARG A 285      16.938  60.924 -10.405  1.00 43.17           C  
ATOM    688  CG  ARG A 285      16.375  60.248 -11.643  1.00 46.88           C  
ATOM    689  CD  ARG A 285      17.242  60.493 -12.864  1.00 50.54           C  
ATOM    690  NE  ARG A 285      18.616  60.059 -12.610  1.00 54.36           N  
ATOM    691  CZ  ARG A 285      19.560  59.966 -13.539  1.00 53.31           C  
ATOM    692  NH1 ARG A 285      19.279  60.275 -14.802  1.00 51.65           N  
ATOM    693  NH2 ARG A 285      20.784  59.571 -13.199  1.00 51.80           N  
ATOM    694  N   PRO A 286      17.709  61.017  -7.219  1.00 41.12           N  
ATOM    695  CA  PRO A 286      18.091  61.848  -6.077  1.00 40.25           C  
ATOM    696  C   PRO A 286      18.625  63.178  -6.578  1.00 40.81           C  
ATOM    697  O   PRO A 286      18.966  63.308  -7.757  1.00 40.14           O  
ATOM    698  CB  PRO A 286      19.174  61.025  -5.385  1.00 38.91           C  
ATOM    699  CG  PRO A 286      19.004  59.638  -5.934  1.00 40.34           C  
ATOM    700  CD  PRO A 286      18.634  59.885  -7.358  1.00 40.30           C  
ATOM    701  N   ALA A 287      18.685  64.163  -5.689  1.00 41.69           N  
ATOM    702  CA  ALA A 287      19.187  65.477  -6.053  1.00 43.01           C  
ATOM    703  C   ALA A 287      20.608  65.319  -6.600  1.00 45.34           C  
ATOM    704  O   ALA A 287      21.056  66.081  -7.455  1.00 43.55           O  
ATOM    705  CB  ALA A 287      19.181  66.375  -4.843  1.00 42.85           C  
ATOM    706  N   SER A 288      21.311  64.308  -6.103  1.00 48.31           N  
ATOM    707  CA  SER A 288      22.662  64.042  -6.554  1.00 50.21           C  
ATOM    708  C   SER A 288      22.676  63.691  -8.039  1.00 52.31           C  
ATOM    709  O   SER A 288      23.641  63.990  -8.730  1.00 54.12           O  
ATOM    710  CB  SER A 288      23.276  62.895  -5.748  1.00 50.74           C  
ATOM    711  OG  SER A 288      22.609  61.668  -5.986  1.00 50.67           O  
ATOM    712  N   HIS A 289      21.605  63.078  -8.540  1.00 54.34           N  
ATOM    713  CA  HIS A 289      21.554  62.693  -9.949  1.00 55.00           C  
ATOM    714  C   HIS A 289      20.515  63.385 -10.820  1.00 55.76           C  
ATOM    715  O   HIS A 289      20.627  63.356 -12.044  1.00 55.66           O  
ATOM    716  CB  HIS A 289      21.372  61.184 -10.071  1.00 56.46           C  
ATOM    717  CG  HIS A 289      22.532  60.401  -9.549  1.00 58.35           C  
ATOM    718  ND1 HIS A 289      22.892  60.406  -8.218  1.00 58.13           N  
ATOM    719  CD2 HIS A 289      23.443  59.626 -10.184  1.00 59.19           C  
ATOM    720  CE1 HIS A 289      23.976  59.669  -8.057  1.00 59.37           C  
ATOM    721  NE2 HIS A 289      24.331  59.185  -9.234  1.00 59.52           N  
ATOM    722  N   GLN A 290      19.502  63.994 -10.213  1.00 56.52           N  
ATOM    723  CA  GLN A 290      18.487  64.680 -11.011  1.00 57.42           C  
ATOM    724  C   GLN A 290      19.146  65.767 -11.849  1.00 58.18           C  
ATOM    725  O   GLN A 290      19.806  66.669 -11.328  1.00 58.08           O  
ATOM    726  CB  GLN A 290      17.403  65.306 -10.130  1.00 56.34           C  
ATOM    727  CG  GLN A 290      16.303  65.966 -10.950  1.00 54.79           C  
ATOM    728  CD  GLN A 290      15.598  64.988 -11.884  1.00 54.99           C  
ATOM    729  OE1 GLN A 290      15.205  65.348 -12.992  1.00 56.16           O  
ATOM    730  NE2 GLN A 290      15.426  63.749 -11.434  1.00 53.73           N  
ATOM    731  N   THR A 291      18.952  65.678 -13.154  1.00 59.07           N  
ATOM    732  CA  THR A 291      19.546  66.628 -14.073  1.00 59.96           C  
ATOM    733  C   THR A 291      18.515  67.558 -14.694  1.00 60.42           C  
ATOM    734  O   THR A 291      17.323  67.246 -14.719  1.00 59.54           O  
ATOM    735  CB  THR A 291      20.285  65.874 -15.188  1.00 59.90           C  
ATOM    736  OG1 THR A 291      20.552  66.769 -16.271  1.00 62.63           O  
ATOM    737  CG2 THR A 291      19.448  64.699 -15.680  1.00 58.73           C  
ATOM    738  N   PHE A 292      18.980  68.706 -15.184  1.00 61.07           N  
ATOM    739  CA  PHE A 292      18.095  69.675 -15.828  1.00 62.42           C  
ATOM    740  C   PHE A 292      18.853  70.620 -16.778  1.00 63.69           C  
ATOM    741  O   PHE A 292      20.060  70.845 -16.628  1.00 61.95           O  
ATOM    742  CB  PHE A 292      17.337  70.497 -14.777  1.00 60.90           C  
ATOM    743  CG  PHE A 292      18.194  71.493 -14.055  1.00 60.60           C  
ATOM    744  CD1 PHE A 292      19.081  71.086 -13.069  1.00 59.65           C  
ATOM    745  CD2 PHE A 292      18.149  72.842 -14.398  1.00 60.22           C  
ATOM    746  CE1 PHE A 292      19.917  72.009 -12.433  1.00 59.51           C  
ATOM    747  CE2 PHE A 292      18.978  73.770 -13.772  1.00 59.15           C  
ATOM    748  CZ  PHE A 292      19.864  73.352 -12.787  1.00 58.95           C  
ATOM    749  N   PRO A 293      18.143  71.177 -17.778  1.00 65.04           N  
ATOM    750  CA  PRO A 293      18.663  72.103 -18.792  1.00 65.93           C  
ATOM    751  C   PRO A 293      19.128  73.443 -18.221  1.00 67.26           C  
ATOM    752  O   PRO A 293      18.335  74.378 -18.096  1.00 67.39           O  
ATOM    753  CB  PRO A 293      17.474  72.281 -19.736  1.00 66.06           C  
ATOM    754  CG  PRO A 293      16.734  70.995 -19.605  1.00 65.30           C  
ATOM    755  CD  PRO A 293      16.769  70.767 -18.118  1.00 65.37           C  
ATOM    756  N   LEU A 294      20.411  73.535 -17.886  1.00 68.77           N  
ATOM    757  CA  LEU A 294      20.975  74.765 -17.332  1.00 70.32           C  
ATOM    758  C   LEU A 294      21.639  75.624 -18.414  1.00 71.64           C  
ATOM    759  O   LEU A 294      22.447  75.124 -19.208  1.00 72.65           O  
ATOM    760  CB  LEU A 294      21.989  74.422 -16.237  1.00 69.67           C  
ATOM    761  CG  LEU A 294      22.734  75.585 -15.574  1.00 70.34           C  
ATOM    762  CD1 LEU A 294      21.760  76.679 -15.164  1.00 69.97           C  
ATOM    763  CD2 LEU A 294      23.500  75.061 -14.365  1.00 70.46           C  
ATOM    764  N   GLN A 295      21.297  76.913 -18.441  1.00 71.39           N  
ATOM    765  CA  GLN A 295      21.846  77.840 -19.430  1.00 71.95           C  
ATOM    766  C   GLN A 295      23.103  78.551 -18.938  1.00 72.75           C  
ATOM    767  O   GLN A 295      23.909  79.031 -19.741  1.00 73.44           O  
ATOM    768  CB  GLN A 295      20.796  78.883 -19.816  1.00 72.02           C  
ATOM    769  N   VAL A 302      23.450  73.391 -21.671  1.00 86.32           N  
ATOM    770  CA  VAL A 302      24.178  72.282 -21.057  1.00 87.86           C  
ATOM    771  C   VAL A 302      23.523  71.832 -19.752  1.00 87.90           C  
ATOM    772  O   VAL A 302      23.216  72.652 -18.883  1.00 88.06           O  
ATOM    773  CB  VAL A 302      25.643  72.666 -20.753  1.00 88.39           C  
ATOM    774  CG1 VAL A 302      26.330  73.131 -22.026  1.00 89.10           C  
ATOM    775  CG2 VAL A 302      25.693  73.750 -19.684  1.00 88.71           C  
ATOM    776  N   GLU A 303      23.326  70.524 -19.611  1.00 87.12           N  
ATOM    777  CA  GLU A 303      22.692  69.978 -18.420  1.00 86.26           C  
ATOM    778  C   GLU A 303      23.548  69.947 -17.163  1.00 84.30           C  
ATOM    779  O   GLU A 303      24.764  69.762 -17.217  1.00 83.27           O  
ATOM    780  CB  GLU A 303      22.140  68.585 -18.716  1.00 88.24           C  
ATOM    781  CG  GLU A 303      20.757  68.642 -19.344  1.00 92.25           C  
ATOM    782  CD  GLU A 303      20.214  67.278 -19.709  1.00 94.85           C  
ATOM    783  OE1 GLU A 303      20.375  66.337 -18.898  1.00 96.33           O  
ATOM    784  OE2 GLU A 303      19.614  67.155 -20.801  1.00 96.22           O  
ATOM    785  N   CYS A 304      22.878  70.129 -16.028  1.00 82.49           N  
ATOM    786  CA  CYS A 304      23.522  70.158 -14.721  1.00 79.77           C  
ATOM    787  C   CYS A 304      22.733  69.378 -13.671  1.00 77.15           C  
ATOM    788  O   CYS A 304      21.577  69.010 -13.879  1.00 77.56           O  
ATOM    789  CB  CYS A 304      23.673  71.616 -14.266  1.00 80.74           C  
ATOM    790  SG  CYS A 304      24.398  71.871 -12.622  1.00 81.98           S  
ATOM    791  N   THR A 305      23.378  69.136 -12.540  1.00 73.66           N  
ATOM    792  CA  THR A 305      22.771  68.425 -11.431  1.00 71.33           C  
ATOM    793  C   THR A 305      22.255  69.430 -10.401  1.00 70.96           C  
ATOM    794  O   THR A 305      22.959  70.372 -10.039  1.00 70.60           O  
ATOM    795  CB  THR A 305      23.803  67.483 -10.786  1.00 70.29           C  
ATOM    796  OG1 THR A 305      23.625  66.168 -11.313  1.00 68.48           O  
ATOM    797  CG2 THR A 305      23.665  67.454  -9.278  1.00 70.42           C  
ATOM    798  N   VAL A 306      21.030  69.227  -9.925  1.00 70.18           N  
ATOM    799  CA  VAL A 306      20.451  70.142  -8.947  1.00 69.82           C  
ATOM    800  C   VAL A 306      21.329  70.299  -7.710  1.00 69.49           C  
ATOM    801  O   VAL A 306      21.385  71.378  -7.127  1.00 70.30           O  
ATOM    802  CB  VAL A 306      19.032  69.695  -8.498  1.00 69.63           C  
ATOM    803  CG1 VAL A 306      18.149  69.460  -9.714  1.00 69.44           C  
ATOM    804  CG2 VAL A 306      19.114  68.454  -7.647  1.00 69.44           C  
ATOM    805  N   ALA A 307      22.012  69.230  -7.310  1.00 68.88           N  
ATOM    806  CA  ALA A 307      22.883  69.290  -6.141  1.00 69.36           C  
ATOM    807  C   ALA A 307      24.026  70.255  -6.428  1.00 70.40           C  
ATOM    808  O   ALA A 307      24.421  71.049  -5.565  1.00 70.01           O  
ATOM    809  CB  ALA A 307      23.430  67.912  -5.822  1.00 68.77           C  
ATOM    810  N   GLN A 308      24.550  70.172  -7.649  1.00 71.06           N  
ATOM    811  CA  GLN A 308      25.635  71.034  -8.096  1.00 71.74           C  
ATOM    812  C   GLN A 308      25.168  72.463  -7.973  1.00 70.87           C  
ATOM    813  O   GLN A 308      25.841  73.307  -7.382  1.00 71.21           O  
ATOM    814  CB  GLN A 308      25.966  70.765  -9.564  1.00 74.18           C  
ATOM    815  CG  GLN A 308      27.227  69.951  -9.810  1.00 77.44           C  
ATOM    816  CD  GLN A 308      27.415  69.608 -11.287  1.00 78.87           C  
ATOM    817  OE1 GLN A 308      27.502  70.498 -12.143  1.00 78.84           O  
ATOM    818  NE2 GLN A 308      27.475  68.310 -11.590  1.00 77.76           N  
ATOM    819  N   TYR A 309      23.996  72.712  -8.548  1.00 69.00           N  
ATOM    820  CA  TYR A 309      23.389  74.029  -8.554  1.00 67.07           C  
ATOM    821  C   TYR A 309      23.430  74.707  -7.189  1.00 66.36           C  
ATOM    822  O   TYR A 309      23.955  75.808  -7.058  1.00 65.97           O  
ATOM    823  CB  TYR A 309      21.944  73.926  -9.029  1.00 66.72           C  
ATOM    824  CG  TYR A 309      21.301  75.259  -9.308  1.00 65.80           C  
ATOM    825  CD1 TYR A 309      21.423  75.871 -10.556  1.00 65.17           C  
ATOM    826  CD2 TYR A 309      20.588  75.925  -8.315  1.00 66.36           C  
ATOM    827  CE1 TYR A 309      20.849  77.117 -10.807  1.00 64.54           C  
ATOM    828  CE2 TYR A 309      20.014  77.170  -8.554  1.00 66.13           C  
ATOM    829  CZ  TYR A 309      20.148  77.757  -9.799  1.00 65.09           C  
ATOM    830  OH  TYR A 309      19.576  78.983 -10.022  1.00 65.43           O  
ATOM    831  N   PHE A 310      22.885  74.056  -6.168  1.00 65.42           N  
ATOM    832  CA  PHE A 310      22.871  74.658  -4.838  1.00 65.25           C  
ATOM    833  C   PHE A 310      24.247  74.750  -4.189  1.00 67.69           C  
ATOM    834  O   PHE A 310      24.414  75.398  -3.157  1.00 67.44           O  
ATOM    835  CB  PHE A 310      21.884  73.914  -3.930  1.00 60.02           C  
ATOM    836  CG  PHE A 310      20.446  74.241  -4.225  1.00 55.79           C  
ATOM    837  CD1 PHE A 310      19.855  73.833  -5.417  1.00 53.17           C  
ATOM    838  CD2 PHE A 310      19.703  75.026  -3.347  1.00 54.49           C  
ATOM    839  CE1 PHE A 310      18.551  74.208  -5.734  1.00 51.58           C  
ATOM    840  CE2 PHE A 310      18.394  75.408  -3.657  1.00 52.64           C  
ATOM    841  CZ  PHE A 310      17.820  74.998  -4.855  1.00 50.39           C  
ATOM    842  N   LYS A 311      25.235  74.113  -4.807  1.00 70.70           N  
ATOM    843  CA  LYS A 311      26.601  74.143  -4.296  1.00 73.08           C  
ATOM    844  C   LYS A 311      27.368  75.229  -5.052  1.00 74.37           C  
ATOM    845  O   LYS A 311      28.228  75.913  -4.492  1.00 74.38           O  
ATOM    846  CB  LYS A 311      27.274  72.784  -4.513  1.00 74.31           C  
ATOM    847  CG  LYS A 311      28.555  72.557  -3.713  1.00 75.51           C  
ATOM    848  CD  LYS A 311      29.736  73.381  -4.209  1.00 77.07           C  
ATOM    849  CE  LYS A 311      30.986  73.096  -3.373  1.00 77.54           C  
ATOM    850  NZ  LYS A 311      32.169  73.903  -3.795  1.00 76.64           N  
ATOM    851  N   GLN A 312      27.043  75.387  -6.330  1.00 74.40           N  
ATOM    852  CA  GLN A 312      27.707  76.379  -7.155  1.00 74.68           C  
ATOM    853  C   GLN A 312      27.083  77.752  -6.958  1.00 74.01           C  
ATOM    854  O   GLN A 312      27.748  78.681  -6.507  1.00 75.35           O  
ATOM    855  CB  GLN A 312      27.634  75.969  -8.632  1.00 76.43           C  
ATOM    856  CG  GLN A 312      28.009  74.501  -8.875  1.00 79.02           C  
ATOM    857  CD  GLN A 312      28.179  74.153 -10.346  1.00 80.22           C  
ATOM    858  OE1 GLN A 312      27.327  74.473 -11.180  1.00 80.73           O  
ATOM    859  NE2 GLN A 312      29.282  73.482 -10.669  1.00 80.56           N  
ATOM    860  N   LYS A 313      25.797  77.869  -7.272  1.00 73.23           N  
ATOM    861  CA  LYS A 313      25.077  79.136  -7.160  1.00 71.19           C  
ATOM    862  C   LYS A 313      24.779  79.636  -5.751  1.00 69.45           C  
ATOM    863  O   LYS A 313      24.773  80.842  -5.518  1.00 70.28           O  
ATOM    864  CB  LYS A 313      23.766  79.066  -7.948  1.00 70.77           C  
ATOM    865  CG  LYS A 313      22.991  80.372  -7.963  1.00 71.13           C  
ATOM    866  CD  LYS A 313      22.002  80.396  -9.113  1.00 72.53           C  
ATOM    867  CE  LYS A 313      21.310  81.743  -9.231  1.00 73.27           C  
ATOM    868  NZ  LYS A 313      20.517  81.848 -10.494  1.00 72.90           N  
ATOM    869  N   TYR A 314      24.526  78.729  -4.816  1.00 67.69           N  
ATOM    870  CA  TYR A 314      24.218  79.136  -3.447  1.00 66.49           C  
ATOM    871  C   TYR A 314      25.280  78.684  -2.470  1.00 66.43           C  
ATOM    872  O   TYR A 314      25.232  79.006  -1.283  1.00 65.90           O  
ATOM    873  CB  TYR A 314      22.852  78.590  -3.029  1.00 64.57           C  
ATOM    874  CG  TYR A 314      21.743  79.238  -3.803  1.00 63.11           C  
ATOM    875  CD1 TYR A 314      21.433  80.578  -3.603  1.00 62.04           C  
ATOM    876  CD2 TYR A 314      21.060  78.545  -4.800  1.00 62.39           C  
ATOM    877  CE1 TYR A 314      20.481  81.215  -4.375  1.00 61.77           C  
ATOM    878  CE2 TYR A 314      20.104  79.177  -5.581  1.00 61.68           C  
ATOM    879  CZ  TYR A 314      19.823  80.513  -5.363  1.00 61.57           C  
ATOM    880  OH  TYR A 314      18.892  81.160  -6.138  1.00 62.43           O  
ATOM    881  N   ASN A 315      26.243  77.935  -2.980  1.00 66.61           N  
ATOM    882  CA  ASN A 315      27.320  77.447  -2.151  1.00 66.87           C  
ATOM    883  C   ASN A 315      26.766  76.766  -0.902  1.00 66.28           C  
ATOM    884  O   ASN A 315      27.002  77.215   0.220  1.00 66.39           O  
ATOM    885  CB  ASN A 315      28.239  78.608  -1.762  1.00 68.07           C  
ATOM    886  CG  ASN A 315      29.591  78.137  -1.267  1.00 70.16           C  
ATOM    887  OD1 ASN A 315      29.700  77.501  -0.216  1.00 70.49           O  
ATOM    888  ND2 ASN A 315      30.636  78.443  -2.031  1.00 71.57           N  
ATOM    889  N   LEU A 316      26.007  75.693  -1.104  1.00 65.88           N  
ATOM    890  CA  LEU A 316      25.457  74.938   0.015  1.00 65.34           C  
ATOM    891  C   LEU A 316      25.395  73.453  -0.326  1.00 64.53           C  
ATOM    892  O   LEU A 316      24.571  73.009  -1.125  1.00 64.79           O  
ATOM    893  CB  LEU A 316      24.069  75.477   0.425  1.00 65.65           C  
ATOM    894  CG  LEU A 316      22.740  75.170  -0.282  1.00 65.63           C  
ATOM    895  CD1 LEU A 316      22.156  73.859   0.227  1.00 64.00           C  
ATOM    896  CD2 LEU A 316      21.751  76.296   0.006  1.00 64.59           C  
ATOM    897  N   GLN A 317      26.311  72.693   0.257  1.00 64.06           N  
ATOM    898  CA  GLN A 317      26.344  71.260   0.030  1.00 63.68           C  
ATOM    899  C   GLN A 317      25.047  70.754   0.628  1.00 61.16           C  
ATOM    900  O   GLN A 317      24.712  71.082   1.766  1.00 60.29           O  
ATOM    901  CB  GLN A 317      27.534  70.620   0.756  1.00 66.69           C  
ATOM    902  CG  GLN A 317      28.908  70.996   0.207  1.00 70.80           C  
ATOM    903  CD  GLN A 317      29.276  70.226  -1.053  1.00 73.13           C  
ATOM    904  OE1 GLN A 317      28.588  70.313  -2.071  1.00 74.95           O  
ATOM    905  NE2 GLN A 317      30.367  69.465  -0.988  1.00 74.12           N  
ATOM    906  N   LEU A 318      24.310  69.969  -0.140  1.00 58.29           N  
ATOM    907  CA  LEU A 318      23.052  69.437   0.351  1.00 56.91           C  
ATOM    908  C   LEU A 318      23.281  68.373   1.419  1.00 55.70           C  
ATOM    909  O   LEU A 318      24.172  67.536   1.289  1.00 57.11           O  
ATOM    910  CB  LEU A 318      22.255  68.849  -0.816  1.00 56.01           C  
ATOM    911  CG  LEU A 318      21.834  69.886  -1.854  1.00 55.58           C  
ATOM    912  CD1 LEU A 318      21.338  69.215  -3.116  1.00 56.30           C  
ATOM    913  CD2 LEU A 318      20.767  70.768  -1.250  1.00 55.74           C  
ATOM    914  N   LYS A 319      22.491  68.416   2.485  1.00 53.92           N  
ATOM    915  CA  LYS A 319      22.605  67.418   3.542  1.00 53.10           C  
ATOM    916  C   LYS A 319      22.088  66.056   3.067  1.00 52.09           C  
ATOM    917  O   LYS A 319      22.590  65.022   3.497  1.00 53.07           O  
ATOM    918  CB  LYS A 319      21.810  67.843   4.781  1.00 54.56           C  
ATOM    919  CG  LYS A 319      22.549  68.760   5.733  1.00 55.20           C  
ATOM    920  CD  LYS A 319      21.688  69.123   6.942  1.00 56.72           C  
ATOM    921  CE  LYS A 319      20.598  70.128   6.582  1.00 56.97           C  
ATOM    922  NZ  LYS A 319      19.800  70.521   7.773  1.00 56.94           N  
ATOM    923  N   TYR A 320      21.087  66.063   2.184  1.00 50.52           N  
ATOM    924  CA  TYR A 320      20.490  64.826   1.675  1.00 48.56           C  
ATOM    925  C   TYR A 320      20.432  64.745   0.147  1.00 47.66           C  
ATOM    926  O   TYR A 320      19.349  64.757  -0.448  1.00 45.64           O  
ATOM    927  CB  TYR A 320      19.069  64.658   2.230  1.00 48.77           C  
ATOM    928  CG  TYR A 320      18.952  64.886   3.717  1.00 48.66           C  
ATOM    929  CD1 TYR A 320      18.767  66.170   4.233  1.00 49.05           C  
ATOM    930  CD2 TYR A 320      19.055  63.823   4.614  1.00 48.58           C  
ATOM    931  CE1 TYR A 320      18.689  66.388   5.610  1.00 48.43           C  
ATOM    932  CE2 TYR A 320      18.983  64.028   5.991  1.00 46.70           C  
ATOM    933  CZ  TYR A 320      18.802  65.309   6.478  1.00 48.15           C  
ATOM    934  OH  TYR A 320      18.758  65.518   7.833  1.00 49.00           O  
ATOM    935  N   PRO A 321      21.601  64.646  -0.509  1.00 47.35           N  
ATOM    936  CA  PRO A 321      21.671  64.560  -1.973  1.00 46.22           C  
ATOM    937  C   PRO A 321      21.086  63.243  -2.468  1.00 45.46           C  
ATOM    938  O   PRO A 321      20.832  63.071  -3.659  1.00 45.04           O  
ATOM    939  CB  PRO A 321      23.170  64.650  -2.256  1.00 45.89           C  
ATOM    940  CG  PRO A 321      23.723  65.345  -1.047  1.00 45.92           C  
ATOM    941  CD  PRO A 321      22.952  64.714   0.070  1.00 46.28           C  
ATOM    942  N   HIS A 322      20.883  62.319  -1.534  1.00 44.85           N  
ATOM    943  CA  HIS A 322      20.337  60.996  -1.831  1.00 45.05           C  
ATOM    944  C   HIS A 322      18.807  60.934  -1.887  1.00 42.56           C  
ATOM    945  O   HIS A 322      18.251  60.004  -2.457  1.00 42.53           O  
ATOM    946  CB  HIS A 322      20.848  59.991  -0.802  1.00 46.55           C  
ATOM    947  CG  HIS A 322      20.727  60.466   0.612  1.00 49.13           C  
ATOM    948  ND1 HIS A 322      19.926  59.839   1.542  1.00 49.34           N  
ATOM    949  CD2 HIS A 322      21.307  61.507   1.254  1.00 49.08           C  
ATOM    950  CE1 HIS A 322      20.019  60.472   2.698  1.00 49.65           C  
ATOM    951  NE2 HIS A 322      20.851  61.489   2.549  1.00 50.54           N  
ATOM    952  N   LEU A 323      18.134  61.911  -1.285  1.00 40.09           N  
ATOM    953  CA  LEU A 323      16.676  61.961  -1.307  1.00 36.10           C  
ATOM    954  C   LEU A 323      16.252  62.675  -2.589  1.00 35.40           C  
ATOM    955  O   LEU A 323      17.030  63.410  -3.180  1.00 34.99           O  
ATOM    956  CB  LEU A 323      16.148  62.710  -0.081  1.00 32.54           C  
ATOM    957  CG  LEU A 323      16.558  62.091   1.256  1.00 30.89           C  
ATOM    958  CD1 LEU A 323      16.072  62.961   2.393  1.00 32.09           C  
ATOM    959  CD2 LEU A 323      16.003  60.688   1.376  1.00 29.21           C  
ATOM    960  N   PRO A 324      15.012  62.457  -3.042  1.00 35.02           N  
ATOM    961  CA  PRO A 324      14.533  63.099  -4.267  1.00 35.13           C  
ATOM    962  C   PRO A 324      14.342  64.611  -4.157  1.00 35.58           C  
ATOM    963  O   PRO A 324      14.506  65.208  -3.092  1.00 35.84           O  
ATOM    964  CB  PRO A 324      13.196  62.400  -4.523  1.00 33.30           C  
ATOM    965  CG  PRO A 324      13.329  61.114  -3.820  1.00 33.19           C  
ATOM    966  CD  PRO A 324      14.027  61.483  -2.556  1.00 33.70           C  
ATOM    967  N   CYS A 325      13.968  65.206  -5.283  1.00 35.92           N  
ATOM    968  CA  CYS A 325      13.685  66.625  -5.376  1.00 36.16           C  
ATOM    969  C   CYS A 325      12.193  66.714  -5.637  1.00 36.56           C  
ATOM    970  O   CYS A 325      11.563  65.748  -6.113  1.00 33.62           O  
ATOM    971  CB  CYS A 325      14.398  67.263  -6.568  1.00 37.72           C  
ATOM    972  SG  CYS A 325      16.164  67.016  -6.597  1.00 43.60           S  
ATOM    973  N   LEU A 326      11.634  67.877  -5.325  1.00 35.56           N  
ATOM    974  CA  LEU A 326      10.227  68.122  -5.559  1.00 33.96           C  
ATOM    975  C   LEU A 326      10.137  68.801  -6.909  1.00 33.88           C  
ATOM    976  O   LEU A 326      11.052  69.524  -7.305  1.00 33.02           O  
ATOM    977  CB  LEU A 326       9.655  69.076  -4.511  1.00 33.23           C  
ATOM    978  CG  LEU A 326       9.585  68.675  -3.040  1.00 32.54           C  
ATOM    979  CD1 LEU A 326       8.916  69.793  -2.255  1.00 31.97           C  
ATOM    980  CD2 LEU A 326       8.805  67.390  -2.895  1.00 31.70           C  
ATOM    981  N   GLN A 327       9.063  68.543  -7.641  1.00 33.00           N  
ATOM    982  CA  GLN A 327       8.890  69.244  -8.891  1.00 34.71           C  
ATOM    983  C   GLN A 327       7.838  70.295  -8.547  1.00 34.75           C  
ATOM    984  O   GLN A 327       6.802  69.982  -7.948  1.00 34.79           O  
ATOM    985  CB  GLN A 327       8.389  68.338 -10.017  1.00 35.47           C  
ATOM    986  CG  GLN A 327       8.233  69.115 -11.333  1.00 36.86           C  
ATOM    987  CD  GLN A 327       7.805  68.261 -12.517  1.00 38.87           C  
ATOM    988  OE1 GLN A 327       7.493  68.789 -13.582  1.00 41.73           O  
ATOM    989  NE2 GLN A 327       7.800  66.943 -12.344  1.00 38.07           N  
ATOM    990  N   VAL A 328       8.111  71.544  -8.895  1.00 33.61           N  
ATOM    991  CA  VAL A 328       7.170  72.602  -8.588  1.00 33.65           C  
ATOM    992  C   VAL A 328       6.799  73.379  -9.827  1.00 35.70           C  
ATOM    993  O   VAL A 328       7.517  73.340 -10.819  1.00 36.69           O  
ATOM    994  CB  VAL A 328       7.752  73.561  -7.535  1.00 32.39           C  
ATOM    995  CG1 VAL A 328       7.881  72.831  -6.186  1.00 28.65           C  
ATOM    996  CG2 VAL A 328       9.108  74.088  -8.003  1.00 26.77           C  
ATOM    997  N   GLY A 329       5.670  74.075  -9.769  1.00 37.22           N  
ATOM    998  CA  GLY A 329       5.230  74.860 -10.905  1.00 42.71           C  
ATOM    999  C   GLY A 329       4.643  74.031 -12.034  1.00 46.77           C  
ATOM   1000  O   GLY A 329       4.266  72.878 -11.842  1.00 47.74           O  
ATOM   1001  N   GLN A 330       4.563  74.628 -13.216  1.00 50.28           N  
ATOM   1002  CA  GLN A 330       4.024  73.963 -14.393  1.00 54.78           C  
ATOM   1003  C   GLN A 330       4.841  72.719 -14.716  1.00 56.60           C  
ATOM   1004  O   GLN A 330       6.066  72.748 -14.632  1.00 56.33           O  
ATOM   1005  CB  GLN A 330       4.073  74.929 -15.569  1.00 57.29           C  
ATOM   1006  CG  GLN A 330       3.460  76.282 -15.255  1.00 61.70           C  
ATOM   1007  CD  GLN A 330       4.045  77.406 -16.099  1.00 64.92           C  
ATOM   1008  OE1 GLN A 330       3.539  78.529 -16.089  1.00 66.12           O  
ATOM   1009  NE2 GLN A 330       5.121  77.110 -16.827  1.00 65.82           N  
ATOM   1010  N   GLU A 331       4.167  71.631 -15.082  1.00 59.28           N  
ATOM   1011  CA  GLU A 331       4.860  70.388 -15.420  1.00 62.10           C  
ATOM   1012  C   GLU A 331       5.973  70.683 -16.414  1.00 63.46           C  
ATOM   1013  O   GLU A 331       7.159  70.580 -16.091  1.00 63.94           O  
ATOM   1014  CB  GLU A 331       3.921  69.378 -16.091  1.00 64.78           C  
ATOM   1015  CG  GLU A 331       2.582  69.122 -15.416  1.00 67.11           C  
ATOM   1016  CD  GLU A 331       1.712  68.153 -16.222  1.00 67.90           C  
ATOM   1017  OE1 GLU A 331       1.489  68.412 -17.430  1.00 66.09           O  
ATOM   1018  OE2 GLU A 331       1.256  67.134 -15.646  1.00 68.02           O  
ATOM   1019  N   GLN A 332       5.560  71.047 -17.630  1.00 64.21           N  
ATOM   1020  CA  GLN A 332       6.466  71.343 -18.741  1.00 65.49           C  
ATOM   1021  C   GLN A 332       7.638  72.265 -18.413  1.00 64.30           C  
ATOM   1022  O   GLN A 332       8.544  72.419 -19.227  1.00 64.93           O  
ATOM   1023  CB  GLN A 332       5.669  71.921 -19.929  1.00 68.39           C  
ATOM   1024  CG  GLN A 332       4.830  70.880 -20.706  1.00 72.03           C  
ATOM   1025  CD  GLN A 332       3.656  71.487 -21.494  1.00 73.55           C  
ATOM   1026  OE1 GLN A 332       2.741  72.082 -20.913  1.00 74.65           O  
ATOM   1027  NE2 GLN A 332       3.677  71.325 -22.818  1.00 72.52           N  
ATOM   1028  N   LYS A 333       7.632  72.867 -17.227  1.00 62.97           N  
ATOM   1029  CA  LYS A 333       8.706  73.771 -16.825  1.00 60.71           C  
ATOM   1030  C   LYS A 333       9.863  73.019 -16.159  1.00 59.46           C  
ATOM   1031  O   LYS A 333      10.974  73.537 -16.042  1.00 59.82           O  
ATOM   1032  CB  LYS A 333       8.156  74.837 -15.876  1.00 61.31           C  
ATOM   1033  CG  LYS A 333       8.852  76.179 -15.978  1.00 61.76           C  
ATOM   1034  CD  LYS A 333       8.237  77.190 -15.029  1.00 63.58           C  
ATOM   1035  CE  LYS A 333       8.808  78.587 -15.261  1.00 64.13           C  
ATOM   1036  NZ  LYS A 333      10.291  78.625 -15.129  1.00 65.23           N  
ATOM   1037  N   HIS A 334       9.591  71.799 -15.716  1.00 58.26           N  
ATOM   1038  CA  HIS A 334      10.591  70.953 -15.077  1.00 57.84           C  
ATOM   1039  C   HIS A 334      11.514  71.627 -14.054  1.00 55.62           C  
ATOM   1040  O   HIS A 334      12.744  71.585 -14.175  1.00 55.27           O  
ATOM   1041  CB  HIS A 334      11.410  70.249 -16.159  1.00 60.62           C  
ATOM   1042  CG  HIS A 334      10.570  69.445 -17.104  1.00 65.82           C  
ATOM   1043  ND1 HIS A 334       9.693  68.470 -16.673  1.00 66.69           N  
ATOM   1044  CD2 HIS A 334      10.430  69.505 -18.451  1.00 66.65           C  
ATOM   1045  CE1 HIS A 334       9.048  67.967 -17.711  1.00 66.78           C  
ATOM   1046  NE2 HIS A 334       9.476  68.579 -18.802  1.00 67.97           N  
ATOM   1047  N   THR A 335      10.904  72.235 -13.037  1.00 52.17           N  
ATOM   1048  CA  THR A 335      11.640  72.896 -11.963  1.00 47.09           C  
ATOM   1049  C   THR A 335      11.737  71.950 -10.775  1.00 44.39           C  
ATOM   1050  O   THR A 335      10.726  71.518 -10.228  1.00 43.55           O  
ATOM   1051  CB  THR A 335      10.931  74.167 -11.516  1.00 45.76           C  
ATOM   1052  OG1 THR A 335      10.673  74.984 -12.662  1.00 46.32           O  
ATOM   1053  CG2 THR A 335      11.797  74.940 -10.533  1.00 43.56           C  
ATOM   1054  N   TYR A 336      12.961  71.626 -10.384  1.00 43.52           N  
ATOM   1055  CA  TYR A 336      13.192  70.710  -9.273  1.00 42.00           C  
ATOM   1056  C   TYR A 336      13.830  71.417  -8.087  1.00 40.04           C  
ATOM   1057  O   TYR A 336      14.749  72.200  -8.248  1.00 40.94           O  
ATOM   1058  CB  TYR A 336      14.086  69.558  -9.732  1.00 41.55           C  
ATOM   1059  CG  TYR A 336      13.607  68.902 -10.999  1.00 41.54           C  
ATOM   1060  CD1 TYR A 336      14.369  68.962 -12.168  1.00 43.23           C  
ATOM   1061  CD2 TYR A 336      12.391  68.218 -11.036  1.00 42.86           C  
ATOM   1062  CE1 TYR A 336      13.940  68.355 -13.348  1.00 42.35           C  
ATOM   1063  CE2 TYR A 336      11.945  67.603 -12.211  1.00 44.44           C  
ATOM   1064  CZ  TYR A 336      12.728  67.675 -13.365  1.00 45.31           C  
ATOM   1065  OH  TYR A 336      12.308  67.058 -14.528  1.00 46.38           O  
ATOM   1066  N   LEU A 337      13.331  71.131  -6.894  1.00 38.71           N  
ATOM   1067  CA  LEU A 337      13.833  71.743  -5.675  1.00 35.93           C  
ATOM   1068  C   LEU A 337      14.223  70.667  -4.689  1.00 35.63           C  
ATOM   1069  O   LEU A 337      13.498  69.685  -4.506  1.00 37.35           O  
ATOM   1070  CB  LEU A 337      12.749  72.620  -5.044  1.00 33.42           C  
ATOM   1071  CG  LEU A 337      12.666  74.108  -5.392  1.00 33.47           C  
ATOM   1072  CD1 LEU A 337      12.974  74.351  -6.847  1.00 33.19           C  
ATOM   1073  CD2 LEU A 337      11.269  74.610  -5.034  1.00 34.01           C  
ATOM   1074  N   PRO A 338      15.380  70.828  -4.039  1.00 34.10           N  
ATOM   1075  CA  PRO A 338      15.829  69.830  -3.058  1.00 33.28           C  
ATOM   1076  C   PRO A 338      14.892  69.916  -1.854  1.00 31.07           C  
ATOM   1077  O   PRO A 338      14.466  71.008  -1.493  1.00 31.45           O  
ATOM   1078  CB  PRO A 338      17.252  70.289  -2.710  1.00 33.37           C  
ATOM   1079  CG  PRO A 338      17.644  71.172  -3.877  1.00 35.29           C  
ATOM   1080  CD  PRO A 338      16.379  71.891  -4.222  1.00 32.26           C  
ATOM   1081  N   LEU A 339      14.568  68.788  -1.239  1.00 28.86           N  
ATOM   1082  CA  LEU A 339      13.675  68.809  -0.089  1.00 31.15           C  
ATOM   1083  C   LEU A 339      14.198  69.725   1.020  1.00 33.70           C  
ATOM   1084  O   LEU A 339      13.432  70.442   1.666  1.00 33.56           O  
ATOM   1085  CB  LEU A 339      13.485  67.399   0.476  1.00 30.32           C  
ATOM   1086  CG  LEU A 339      13.108  66.253  -0.469  1.00 31.16           C  
ATOM   1087  CD1 LEU A 339      12.720  65.070   0.384  1.00 29.62           C  
ATOM   1088  CD2 LEU A 339      11.952  66.633  -1.388  1.00 30.86           C  
ATOM   1089  N   GLU A 340      15.506  69.694   1.240  1.00 36.50           N  
ATOM   1090  CA  GLU A 340      16.143  70.510   2.271  1.00 37.70           C  
ATOM   1091  C   GLU A 340      15.729  71.965   2.321  1.00 36.74           C  
ATOM   1092  O   GLU A 340      15.511  72.505   3.400  1.00 39.27           O  
ATOM   1093  CB  GLU A 340      17.648  70.488   2.099  1.00 40.83           C  
ATOM   1094  CG  GLU A 340      18.283  69.185   2.441  1.00 45.47           C  
ATOM   1095  CD  GLU A 340      19.689  69.147   1.960  1.00 46.33           C  
ATOM   1096  OE1 GLU A 340      20.439  70.099   2.270  1.00 48.35           O  
ATOM   1097  OE2 GLU A 340      20.035  68.175   1.264  1.00 48.59           O  
ATOM   1098  N   VAL A 341      15.653  72.600   1.157  1.00 34.94           N  
ATOM   1099  CA  VAL A 341      15.300  74.015   1.066  1.00 32.82           C  
ATOM   1100  C   VAL A 341      13.804  74.288   1.103  1.00 32.12           C  
ATOM   1101  O   VAL A 341      13.378  75.430   0.932  1.00 31.96           O  
ATOM   1102  CB  VAL A 341      15.855  74.651  -0.239  1.00 32.35           C  
ATOM   1103  CG1 VAL A 341      17.348  74.432  -0.339  1.00 31.94           C  
ATOM   1104  CG2 VAL A 341      15.158  74.069  -1.441  1.00 29.46           C  
ATOM   1105  N   CYS A 342      13.005  73.255   1.338  1.00 31.12           N  
ATOM   1106  CA  CYS A 342      11.561  73.434   1.350  1.00 30.77           C  
ATOM   1107  C   CYS A 342      10.818  73.290   2.675  1.00 30.37           C  
ATOM   1108  O   CYS A 342      11.097  72.405   3.482  1.00 29.94           O  
ATOM   1109  CB  CYS A 342      10.924  72.500   0.328  1.00 28.44           C  
ATOM   1110  SG  CYS A 342      11.352  72.891  -1.354  1.00 29.09           S  
ATOM   1111  N   ASN A 343       9.850  74.179   2.859  1.00 30.18           N  
ATOM   1112  CA  ASN A 343       8.998  74.205   4.032  1.00 32.93           C  
ATOM   1113  C   ASN A 343       7.542  74.164   3.557  1.00 35.25           C  
ATOM   1114  O   ASN A 343       7.187  74.824   2.576  1.00 36.84           O  
ATOM   1115  CB  ASN A 343       9.225  75.492   4.816  1.00 35.16           C  
ATOM   1116  CG  ASN A 343      10.297  75.357   5.853  1.00 34.75           C  
ATOM   1117  OD1 ASN A 343      11.412  74.962   5.561  1.00 38.51           O  
ATOM   1118  ND2 ASN A 343       9.961  75.688   7.083  1.00 39.61           N  
ATOM   1119  N   ILE A 344       6.702  73.395   4.239  1.00 34.94           N  
ATOM   1120  CA  ILE A 344       5.303  73.325   3.854  1.00 36.46           C  
ATOM   1121  C   ILE A 344       4.620  74.581   4.348  1.00 39.31           C  
ATOM   1122  O   ILE A 344       4.738  74.934   5.521  1.00 40.56           O  
ATOM   1123  CB  ILE A 344       4.583  72.085   4.463  1.00 34.41           C  
ATOM   1124  CG1 ILE A 344       5.048  70.818   3.744  1.00 33.68           C  
ATOM   1125  CG2 ILE A 344       3.058  72.235   4.340  1.00 30.60           C  
ATOM   1126  CD1 ILE A 344       4.407  69.560   4.251  1.00 34.75           C  
ATOM   1127  N   VAL A 345       3.911  75.249   3.442  1.00 41.53           N  
ATOM   1128  CA  VAL A 345       3.193  76.473   3.769  1.00 43.96           C  
ATOM   1129  C   VAL A 345       1.802  76.128   4.295  1.00 47.07           C  
ATOM   1130  O   VAL A 345       0.979  75.543   3.584  1.00 47.26           O  
ATOM   1131  CB  VAL A 345       3.055  77.380   2.520  1.00 43.15           C  
ATOM   1132  CG1 VAL A 345       2.294  78.656   2.869  1.00 40.81           C  
ATOM   1133  CG2 VAL A 345       4.427  77.706   1.967  1.00 41.40           C  
ATOM   1134  N   ALA A 346       1.545  76.485   5.546  1.00 51.26           N  
ATOM   1135  CA  ALA A 346       0.245  76.220   6.156  1.00 55.85           C  
ATOM   1136  C   ALA A 346      -0.797  77.249   5.691  1.00 58.47           C  
ATOM   1137  O   ALA A 346      -0.501  78.446   5.594  1.00 58.20           O  
ATOM   1138  CB  ALA A 346       0.371  76.245   7.681  1.00 54.37           C  
ATOM   1139  N   GLY A 347      -2.008  76.772   5.397  1.00 61.19           N  
ATOM   1140  CA  GLY A 347      -3.080  77.656   4.963  1.00 64.21           C  
ATOM   1141  C   GLY A 347      -3.398  78.696   6.026  1.00 66.99           C  
ATOM   1142  O   GLY A 347      -3.029  78.533   7.193  1.00 66.12           O  
ATOM   1143  N   GLN A 348      -4.081  79.768   5.636  1.00 69.57           N  
ATOM   1144  CA  GLN A 348      -4.412  80.816   6.593  1.00 72.70           C  
ATOM   1145  C   GLN A 348      -5.871  81.257   6.564  1.00 74.13           C  
ATOM   1146  O   GLN A 348      -6.171  82.424   6.816  1.00 75.40           O  
ATOM   1147  CB  GLN A 348      -3.513  82.035   6.373  1.00 71.99           C  
ATOM   1148  CG  GLN A 348      -2.030  81.723   6.407  1.00 72.94           C  
ATOM   1149  CD  GLN A 348      -1.187  82.935   6.769  1.00 73.57           C  
ATOM   1150  OE1 GLN A 348      -1.199  83.392   7.914  1.00 73.02           O  
ATOM   1151  NE2 GLN A 348      -0.452  83.462   5.792  1.00 73.34           N  
ATOM   1152  N   ARG A 349      -6.778  80.331   6.264  1.00 75.57           N  
ATOM   1153  CA  ARG A 349      -8.202  80.659   6.218  1.00 76.53           C  
ATOM   1154  C   ARG A 349      -8.659  81.364   7.497  1.00 76.32           C  
ATOM   1155  O   ARG A 349      -8.097  81.156   8.574  1.00 75.86           O  
ATOM   1156  CB  ARG A 349      -9.040  79.391   6.009  1.00 77.53           C  
ATOM   1157  CG  ARG A 349      -9.108  78.887   4.573  1.00 77.97           C  
ATOM   1158  CD  ARG A 349     -10.036  77.683   4.488  1.00 79.51           C  
ATOM   1159  NE  ARG A 349     -10.267  77.223   3.121  1.00 81.74           N  
ATOM   1160  CZ  ARG A 349      -9.307  76.870   2.269  1.00 82.97           C  
ATOM   1161  NH1 ARG A 349      -8.032  76.926   2.635  1.00 83.72           N  
ATOM   1162  NH2 ARG A 349      -9.625  76.451   1.051  1.00 83.50           N  
TER    1163      ARG A 349                                                      
HETATM 1164  O   HOH B 508      13.630  79.680  -5.254  1.00 33.56           O  
HETATM 1165  O   HOH A 501       2.254  70.392   8.847  1.00 26.66           O  
HETATM 1166  O   HOH A 502      15.832  58.866  -2.538  1.00 37.21           O  
HETATM 1167  O   HOH A 503       7.896  71.728 -13.129  1.00 27.50           O  
HETATM 1168  O   HOH A 504      13.275  61.417 -11.770  1.00 39.36           O  
HETATM 1169  O   HOH A 505       4.678  82.112  -5.643  1.00 38.29           O  
HETATM 1170  O   HOH A 506       2.801  72.843 -17.746  1.00 43.28           O  
HETATM 1171  O   HOH A 507       5.673  59.299  12.294  1.00 30.63           O  
HETATM 1172  O   HOH A 509      13.679  73.435   6.210  1.00 40.95           O  
HETATM 1173  O   HOH A 510       9.133  61.975  12.957  1.00 50.66           O  
HETATM 1174  O   HOH A 511       4.508  80.113   6.150  1.00 34.88           O  
HETATM 1175  O   HOH A 512      -1.228  65.367   2.445  1.00 32.82           O  
HETATM 1176  O   HOH A 513      14.493  55.145   5.008  1.00 44.74           O  
HETATM 1177  O   HOH A 514      17.121  68.028 -19.442  1.00 41.63           O  
HETATM 1178  O   HOH A 515      -0.111  73.376   1.579  1.00 36.97           O  
HETATM 1179  O   HOH A 516      13.238  70.761   4.557  1.00 46.87           O  
MASTER      304    0    0    3    8    0    0    6 1177    2    0   13          
END

Display Options: Goto PDB code: 3D presentation of molecule is powered by 3Dmol, which supports all modern browsers and mobile devices via WebGL.
Hold mouse button: left to rotate,middle to shift,right to zoom

Related entries of code: 1si2

Entries with 90% protein sequence similarity cutoff in PDBbind
PDB Code	Check Database	Protein Sequence Similarity
1si3	RCSB PDB PDBbind	149aa, >1SI3_2\|Chain... at 100%
Complexes with the same small molecule ligand
PDB Code	Check Database	Ligand Name
1si3	RCSB PDB PDBbind	9-mer
3gib	RCSB PDB PDBbind	9-mer
3h15	RCSB PDB PDBbind	9-mer
3k5q	RCSB PDB PDBbind	9-mer
3k5y	RCSB PDB PDBbind	9-mer
3k5z	RCSB PDB PDBbind	9-mer
3k61	RCSB PDB PDBbind	9-mer
3k62	RCSB PDB PDBbind	9-mer
3k64	RCSB PDB PDBbind	9-mer
5yki	RCSB PDB PDBbind	9-mer
5zvb	RCSB PDB PDBbind	9-mer

Entry Information

PDB ID	1si2
Complex Type	Protein-Nucleic Acid
PDBbind Subset	general set
Protein Name	Eukaryotic translation initiation factor 2C 1
Ligand Name	9-mer
EC.Number	E.C.-.-.-.-
Resolution	2.6(Å)
Affinity (Kd/Ki/IC50)	Kd=0.89nM
Release Year	2004
Protein/NA Sequence	Check fasta file
Primary Reference	Nature. (2004) 429, pp. 318-22

Links to External Databases

RCSB PDB	The mother database
PDBsum	Enhanced annotations on PDB entries
Pubchem	Comprehensive collection of chemical and biological data
UniProtKB AC	UniProt accession number (AC): Q9UL18
Entrez Gene ID	NCBI Entrez Gene ID: 26523
ASD	Information of known allosteric effects of PDB entries

This site has been visited

times since Nov 2007.

Technical Support（技术支持）: yingsaisi@foxmail.com