Welcome to PDBbind-CN database

Browse entries in the PDBbind-CN Database

HEADER    RNA BINDING PROTEIN/RNA                 21-FEB-06   2G4B              
TITLE     STRUCTURE OF U2AF65 VARIANT WITH POLYURIDINE TRACT                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 5'-R(P*UP*UP*UP*UP*UP*UP*U)-3';                            
COMPND   3 CHAIN: B;                                                            
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 OTHER_DETAILS: POLYPYRIMIDINE TRACT;                                 
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: SPLICING FACTOR U2AF 65 KDA SUBUNIT;                       
COMPND   8 CHAIN: A;                                                            
COMPND   9 FRAGMENT: RNA BINDING DOMAIN;                                        
COMPND  10 SYNONYM: U2 AUXILIARY FACTOR 65 KDA SUBUNIT, U2 SNRNP AUXILIARY      
COMPND  11 FACTOR LARGE SUBUNIT, HU2AF65;                                       
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 SYNTHETIC: YES;                                                      
SOURCE   3 MOL_ID: 2;                                                           
SOURCE   4 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   5 ORGANISM_COMMON: HUMAN;                                              
SOURCE   6 ORGANISM_TAXID: 9606;                                                
SOURCE   7 GENE: U2AF65;                                                        
SOURCE   8 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21;                            
SOURCE   9 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE  10 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE  11 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  12 EXPRESSION_SYSTEM_PLASMID: PGEX-6P                                   
KEYWDS    PROTEIN-RNA COMPLEX, RNA SPLICING FACTOR, RNA RECOGNITION MOTIF, RNA  
KEYWDS   2 BINDING PROTEIN-RNA COMPLEX                                          
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    E.A.SICKMIER,C.L.KIELKOPF                                             
REVDAT   4   31-JAN-18 2G4B    1       JRNL                                     
REVDAT   3   16-AUG-17 2G4B    1       SOURCE REMARK                            
REVDAT   2   24-FEB-09 2G4B    1       VERSN                                    
REVDAT   1   25-JUL-06 2G4B    0                                                
JRNL        AUTH   E.A.SICKMIER,K.E.FRATO,S.PARANAWITHANA,H.SHEN,M.R.GREEN,     
JRNL        AUTH 2 C.L.KIELKOPF                                                 
JRNL        TITL   STRUCTURAL BASIS OF POLYPYRIMIDINE TRACT RECOGNITION BY THE  
JRNL        TITL 2 ESSENTIAL SPLICING FACTOR U2AF65.                            
JRNL        REF    MOL.CELL                      V.  23    49 2006              
JRNL        REFN                   ISSN 1097-2765                               
JRNL        PMID   16818232                                                     
JRNL        DOI    10.1016/J.MOLCEL.2006.05.025                                 
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   E.A.SICKMIER,K.E.FRATO,C.L.KIELKOPF                          
REMARK   1  TITL   CRYSTALLIZATION AND PRELIMINARY X-RAY ANALYSIS OF A U2AF65   
REMARK   1  TITL 2 VARIANT IN COMPLEX WITH A POLYPYRIMIDINE-TRACT ANALOGUE BY   
REMARK   1  TITL 3 USE OF PROTEIN ENGINEERING.                                  
REMARK   1  REF    ACTA CRYSTALLOGR.,SECT.F      V.  62   457 2006              
REMARK   1  REFN                   ESSN 1744-3091                               
REMARK   1  PMID   16682775                                                     
REMARK   1  DOI    10.1107/S1744309106012504                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS                                                  
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU,              
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : ENGH & HUBER                                    
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.50                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 20.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL                           
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL                           
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : NULL                           
REMARK   3   NUMBER OF REFLECTIONS             : 9684                           
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : NULL                            
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.261                           
REMARK   3   FREE R VALUE                     : 0.276                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL                            
REMARK   3   FREE R VALUE TEST SET COUNT      : 996                             
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL                         
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL                         
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL                         
REMARK   3   BIN R VALUE           (WORKING SET) : NULL                         
REMARK   3   BIN FREE R VALUE                    : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL                         
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL                         
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 1332                                    
REMARK   3   NUCLEIC ACID ATOMS       : 141                                     
REMARK   3   HETEROGEN ATOMS          : 6                                       
REMARK   3   SOLVENT ATOMS            : 30                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL                            
REMARK   3   ESD FROM SIGMAA              (A) : NULL                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.007                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.510                           
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL                            
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : NULL                                      
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : NULL                                                 
REMARK   3   KSOL        : NULL                                                 
REMARK   3   BSOL        : NULL                                                 
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 2G4B COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 28-FEB-06.                  
REMARK 100 THE DEPOSITION ID IS D_1000036670.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 06-APR-05                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : NSLS                               
REMARK 200  BEAMLINE                       : X8C                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0                                
REMARK 200  MONOCHROMATOR                  : PARABOLIC COLLIMATING MIRROR       
REMARK 200                                   PLACED UPSTREAM OF THE             
REMARK 200                                   MONOCHROMATOR                      
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 4                     
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 11182                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.500                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -1.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.7                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.50                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.59                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.7                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: CNS                                                   
REMARK 200 STARTING MODEL: PDB ENTRY: 2FZR                                      
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 65.83                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.60                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: .6 M AMMONIUM SULFATE, 100 MM 2-(N       
REMARK 280  -MORPHOLINO) ETHANESULFONIC ACID, SODIUM SALT (MES) PH 6.5, 10%     
REMARK 280  DIOXANE, 200 MM NON-DETERGENT SULFOBETAINE (NDSB) 195 , VAPOR       
REMARK 280  DIFFUSION, HANGING DROP, TEMPERATURE 277K                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 65 2 2                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+2/3                                            
REMARK 290       3555   -X+Y,-X,Z+1/3                                           
REMARK 290       4555   -X,-Y,Z+1/2                                             
REMARK 290       5555   Y,-X+Y,Z+1/6                                            
REMARK 290       6555   X-Y,X,Z+5/6                                             
REMARK 290       7555   Y,X,-Z+2/3                                              
REMARK 290       8555   X-Y,-Y,-Z                                               
REMARK 290       9555   -X,-X+Y,-Z+1/3                                          
REMARK 290      10555   -Y,-X,-Z+1/6                                            
REMARK 290      11555   -X+Y,Y,-Z+1/2                                           
REMARK 290      12555   X,X-Y,-Z+5/6                                            
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       41.76333            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       20.88167            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       31.32250            
REMARK 290   SMTRY1   5  0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   5 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       10.44083            
REMARK 290   SMTRY1   6  0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       52.20417            
REMARK 290   SMTRY1   7 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   7  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       41.76333            
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   9 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   9 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   9  0.000000  0.000000 -1.000000       20.88167            
REMARK 290   SMTRY1  10  0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  10 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3  10  0.000000  0.000000 -1.000000       10.44083            
REMARK 290   SMTRY1  11 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2  11  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3  11  0.000000  0.000000 -1.000000       31.32250            
REMARK 290   SMTRY1  12  0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  12  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3  12  0.000000  0.000000 -1.000000       52.20417            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300 REMARK: THE SECOND PART OF THE BIOLOGICAL ASSEMBLY IS GENERATED BY   
REMARK 300 THE FOLLOWING SIX-FOLD AXIS: MATRIX 0.5001393 0.8659449 0.0003453 -  
REMARK 300 0.8659446 0.5001394 -0.0007568 -0.0008280 0.0000795 0.9999996        
REMARK 300 TRANSLATION 129.3170471 -0.0240173 -10.3325310                       
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, A                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2  0.500000  0.866025  0.000000      -64.69400            
REMARK 350   BIOMT2   2 -0.866025  0.500000  0.000000      112.05329            
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000       10.44083            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500      U B   1   P       U B   1   OP3    -0.081                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500      U B   1   C2' -  C3' -  O3' ANGL. DEV. =  13.1 DEGREES          
REMARK 500      U B   3   C2' -  C3' -  O3' ANGL. DEV. =  15.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ILE A 310        0.75    -58.04                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    ALA A 335        -13.72                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DIO A 41                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 2FZR   RELATED DB: PDB                                   
REMARK 900 UNLIGANDED U2AF65 RRM1                                               
DBREF  2G4B A  148   237  UNP    P26368   U2AF2_HUMAN    148    237             
DBREF  2G4B A  258   336  UNP    P26368   U2AF2_HUMAN    258    336             
DBREF  2G4B B    1     7  PDB    2G4B     2G4B             1      7             
SEQRES   1 B    7    U   U   U   U   U   U   U                                  
SEQRES   1 A  172  LEU GLY SER ALA ARG ARG LEU TYR VAL GLY ASN ILE PRO          
SEQRES   2 A  172  PHE GLY ILE THR GLU GLU ALA MET MET ASP PHE PHE ASN          
SEQRES   3 A  172  ALA GLN MET ARG LEU GLY GLY LEU THR GLN ALA PRO GLY          
SEQRES   4 A  172  ASN PRO VAL LEU ALA VAL GLN ILE ASN GLN ASP LYS ASN          
SEQRES   5 A  172  PHE ALA PHE LEU GLU PHE ARG SER VAL ASP GLU THR THR          
SEQRES   6 A  172  GLN ALA MET ALA PHE ASP GLY ILE ILE PHE GLN GLY GLN          
SEQRES   7 A  172  SER LEU LYS ILE ARG ARG PRO HIS ASP TYR GLN PRO LEU          
SEQRES   8 A  172  PRO GLY ALA HIS LYS LEU PHE ILE GLY GLY LEU PRO ASN          
SEQRES   9 A  172  TYR LEU ASN ASP ASP GLN VAL LYS GLU LEU LEU THR SER          
SEQRES  10 A  172  PHE GLY PRO LEU LYS ALA PHE ASN LEU VAL LYS ASP SER          
SEQRES  11 A  172  ALA THR GLY LEU SER LYS GLY TYR ALA PHE CYS GLU TYR          
SEQRES  12 A  172  VAL ASP ILE ASN VAL THR ASP GLN ALA ILE ALA GLY LEU          
SEQRES  13 A  172  ASN GLY MET GLN LEU GLY ASP LYS LYS LEU LEU VAL GLN          
SEQRES  14 A  172  ARG ALA SER                                                  
HET    DIO  A  41       6                                                       
HETNAM     DIO 1,4-DIETHYLENE DIOXIDE                                           
FORMUL   3  DIO    C4 H8 O2                                                     
FORMUL   4  HOH   *30(H2 O)                                                     
HELIX    1   1 GLY A  146  ALA A  148  5                                   3    
HELIX    2   2 THR A  161  GLY A  176  1                                  16    
HELIX    3   3 SER A  204  MET A  212  1                                   9    
HELIX    4   4 ALA A  213  ASP A  215  5                                   3    
HELIX    5   5 ASN A  271  SER A  281  1                                  11    
HELIX    6   6 ASN A  311  ASN A  321  1                                  11    
SHEET    1   A 4 VAL A 186  ASN A 192  0                                        
SHEET    2   A 4 PHE A 197  PHE A 202 -1  O  PHE A 197   N  ASN A 192           
SHEET    3   A 4 ARG A 150  GLY A 154 -1  N  VAL A 153   O  ALA A 198           
SHEET    4   A 4 LYS A 225  ARG A 227 -1  O  ARG A 227   N  TYR A 152           
SHEET    1   B 2 ILE A 218  PHE A 219  0                                        
SHEET    2   B 2 GLN A 222  SER A 223 -1  O  GLN A 222   N  PHE A 219           
SHEET    1   C 4 LEU A 285  LYS A 292  0                                        
SHEET    2   C 4 SER A 299  TYR A 307 -1  O  GLU A 306   N  LYS A 286           
SHEET    3   C 4 LEU A 261  GLY A 264 -1  N  ILE A 263   O  ALA A 303           
SHEET    4   C 4 LEU A 331  ARG A 334 -1  O  GLN A 333   N  PHE A 262           
SHEET    1   D 2 GLN A 324  LEU A 325  0                                        
SHEET    2   D 2 LYS A 328  LYS A 329 -1  O  LYS A 328   N  LEU A 325           
SITE     1 AC1  3 LYS A 225  ARG A 227  HOH B  28                               
CRYST1  129.388  129.388   62.645  90.00  90.00 120.00 P 65 2 2     12          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.007729  0.004462  0.000000        0.00000                         
SCALE2      0.000000  0.008924  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.015963        0.00000                         
ATOM      1  OP3   U B   1      26.624 157.113 -67.521  1.00 98.97           O  
ATOM      2  P     U B   1      27.490 157.945 -68.462  1.00 99.73           P  
ATOM      3  OP1   U B   1      27.075 157.800 -69.924  1.00 99.73           O  
ATOM      4  OP2   U B   1      27.618 159.405 -68.039  1.00 99.73           O  
ATOM      5  O5'   U B   1      28.997 157.324 -68.343  1.00 99.73           O  
ATOM      6  C5'   U B   1      30.106 157.943 -69.024  1.00 99.37           C  
ATOM      7  C4'   U B   1      31.147 156.911 -69.406  1.00 99.16           C  
ATOM      8  O4'   U B   1      32.026 156.666 -68.275  1.00 99.73           O  
ATOM      9  C3'   U B   1      30.559 155.554 -69.752  1.00 98.28           C  
ATOM     10  O3'   U B   1      30.612 155.122 -71.116  1.00 98.74           O  
ATOM     11  C2'   U B   1      30.685 154.674 -68.506  1.00 98.36           C  
ATOM     12  O2'   U B   1      31.060 153.334 -68.748  1.00 97.38           O  
ATOM     13  C1'   U B   1      31.825 155.364 -67.752  1.00 99.07           C  
ATOM     14  N1    U B   1      31.695 155.448 -66.290  1.00 99.44           N  
ATOM     15  C2    U B   1      32.733 154.923 -65.534  1.00 99.73           C  
ATOM     16  O2    U B   1      33.724 154.413 -66.033  1.00 99.73           O  
ATOM     17  N3    U B   1      32.573 155.020 -64.175  1.00 99.65           N  
ATOM     18  C4    U B   1      31.506 155.576 -63.504  1.00 99.73           C  
ATOM     19  O4    U B   1      31.512 155.589 -62.270  1.00 99.73           O  
ATOM     20  C5    U B   1      30.470 156.097 -64.352  1.00 99.73           C  
ATOM     21  C6    U B   1      30.598 156.017 -65.684  1.00 99.52           C  
ATOM     22  P     U B   2      31.757 154.094 -71.617  1.00 98.43           P  
ATOM     23  OP1   U B   2      32.678 153.711 -70.512  1.00 97.35           O  
ATOM     24  OP2   U B   2      32.324 154.645 -72.880  1.00 98.96           O  
ATOM     25  O5'   U B   2      30.933 152.807 -72.046  1.00 95.41           O  
ATOM     26  C5'   U B   2      31.338 152.037 -73.162  1.00 90.91           C  
ATOM     27  C4'   U B   2      30.728 150.672 -73.082  1.00 86.07           C  
ATOM     28  O4'   U B   2      29.291 150.817 -73.045  1.00 86.65           O  
ATOM     29  C3'   U B   2      31.044 149.846 -74.316  1.00 83.86           C  
ATOM     30  O3'   U B   2      31.479 148.540 -73.975  1.00 78.69           O  
ATOM     31  C2'   U B   2      29.827 149.962 -75.229  1.00 85.42           C  
ATOM     32  O2'   U B   2      29.465 148.711 -75.780  1.00 88.58           O  
ATOM     33  C1'   U B   2      28.720 150.344 -74.243  1.00 85.90           C  
ATOM     34  N1    U B   2      27.728 151.315 -74.719  1.00 86.02           N  
ATOM     35  C2    U B   2      26.537 150.805 -75.202  1.00 86.90           C  
ATOM     36  O2    U B   2      26.299 149.610 -75.246  1.00 87.74           O  
ATOM     37  N3    U B   2      25.634 151.743 -75.631  1.00 87.73           N  
ATOM     38  C4    U B   2      25.799 153.111 -75.628  1.00 87.80           C  
ATOM     39  O4    U B   2      24.894 153.828 -76.061  1.00 88.76           O  
ATOM     40  C5    U B   2      27.060 153.561 -75.113  1.00 86.96           C  
ATOM     41  C6    U B   2      27.959 152.669 -74.687  1.00 86.17           C  
ATOM     42  P     U B   3      32.810 147.933 -74.615  1.00 71.90           P  
ATOM     43  OP1   U B   3      33.942 148.855 -74.336  1.00 72.74           O  
ATOM     44  OP2   U B   3      32.496 147.548 -76.013  1.00 72.36           O  
ATOM     45  O5'   U B   3      33.013 146.625 -73.738  1.00 69.85           O  
ATOM     46  C5'   U B   3      32.675 146.641 -72.361  1.00 65.01           C  
ATOM     47  C4'   U B   3      33.140 145.377 -71.691  1.00 65.54           C  
ATOM     48  O4'   U B   3      32.235 144.291 -72.023  1.00 66.04           O  
ATOM     49  C3'   U B   3      34.498 144.916 -72.182  1.00 64.92           C  
ATOM     50  O3'   U B   3      35.718 145.382 -71.615  1.00 64.55           O  
ATOM     51  C2'   U B   3      34.271 143.847 -73.246  1.00 64.16           C  
ATOM     52  O2'   U B   3      35.178 142.773 -73.148  1.00 66.25           O  
ATOM     53  C1'   U B   3      32.866 143.354 -72.887  1.00 63.83           C  
ATOM     54  N1    U B   3      31.944 143.037 -73.989  1.00 58.92           N  
ATOM     55  C2    U B   3      31.674 141.699 -74.240  1.00 55.22           C  
ATOM     56  O2    U B   3      32.209 140.788 -73.642  1.00 54.29           O  
ATOM     57  N3    U B   3      30.747 141.467 -75.220  1.00 52.82           N  
ATOM     58  C4    U B   3      30.085 142.403 -75.973  1.00 53.38           C  
ATOM     59  O4    U B   3      29.237 142.033 -76.792  1.00 54.71           O  
ATOM     60  C5    U B   3      30.441 143.759 -75.683  1.00 54.24           C  
ATOM     61  C6    U B   3      31.341 144.021 -74.725  1.00 57.06           C  
ATOM     62  P     U B   4      36.446 144.547 -70.459  1.00 64.07           P  
ATOM     63  OP1   U B   4      37.366 145.510 -69.815  1.00 65.59           O  
ATOM     64  OP2   U B   4      36.987 143.293 -71.029  1.00 68.30           O  
ATOM     65  O5'   U B   4      35.298 144.194 -69.415  1.00 64.11           O  
ATOM     66  C5'   U B   4      35.005 145.067 -68.319  1.00 64.29           C  
ATOM     67  C4'   U B   4      34.454 144.273 -67.166  1.00 61.65           C  
ATOM     68  O4'   U B   4      33.261 143.600 -67.613  1.00 61.93           O  
ATOM     69  C3'   U B   4      35.396 143.175 -66.716  1.00 62.59           C  
ATOM     70  O3'   U B   4      36.301 143.655 -65.705  1.00 66.79           O  
ATOM     71  C2'   U B   4      34.511 141.986 -66.340  1.00 61.29           C  
ATOM     72  O2'   U B   4      34.365 141.728 -64.962  1.00 64.76           O  
ATOM     73  C1'   U B   4      33.177 142.323 -67.016  1.00 61.42           C  
ATOM     74  N1    U B   4      32.690 141.361 -68.014  1.00 59.86           N  
ATOM     75  C2    U B   4      31.773 140.419 -67.589  1.00 58.58           C  
ATOM     76  O2    U B   4      31.355 140.372 -66.444  1.00 56.29           O  
ATOM     77  N3    U B   4      31.357 139.539 -68.553  1.00 58.84           N  
ATOM     78  C4    U B   4      31.750 139.510 -69.876  1.00 60.40           C  
ATOM     79  O4    U B   4      31.277 138.655 -70.627  1.00 61.31           O  
ATOM     80  C5    U B   4      32.696 140.521 -70.243  1.00 58.30           C  
ATOM     81  C6    U B   4      33.122 141.389 -69.323  1.00 59.91           C  
ATOM     82  P     U B   5      35.749 144.366 -64.347  1.00 63.08           P  
ATOM     83  OP1   U B   5      34.447 143.836 -63.885  1.00 64.39           O  
ATOM     84  OP2   U B   5      35.907 145.822 -64.564  1.00 64.69           O  
ATOM     85  O5'   U B   5      36.806 143.941 -63.239  1.00 63.31           O  
ATOM     86  C5'   U B   5      37.333 142.614 -63.184  1.00 62.90           C  
ATOM     87  C4'   U B   5      38.832 142.673 -63.049  1.00 61.84           C  
ATOM     88  O4'   U B   5      39.384 143.266 -64.236  1.00 63.75           O  
ATOM     89  C3'   U B   5      39.337 143.542 -61.903  1.00 61.65           C  
ATOM     90  O3'   U B   5      39.733 142.673 -60.852  1.00 62.34           O  
ATOM     91  C2'   U B   5      40.633 144.178 -62.432  1.00 64.05           C  
ATOM     92  O2'   U B   5      41.812 143.642 -61.884  1.00 70.00           O  
ATOM     93  C1'   U B   5      40.637 143.787 -63.905  1.00 62.07           C  
ATOM     94  N1    U B   5      41.077 144.775 -64.892  1.00 58.93           N  
ATOM     95  C2    U B   5      42.389 145.205 -64.808  1.00 58.83           C  
ATOM     96  O2    U B   5      43.155 144.847 -63.922  1.00 56.07           O  
ATOM     97  N3    U B   5      42.773 146.069 -65.800  1.00 57.69           N  
ATOM     98  C4    U B   5      41.994 146.540 -66.831  1.00 57.74           C  
ATOM     99  O4    U B   5      42.486 147.300 -67.658  1.00 59.34           O  
ATOM    100  C5    U B   5      40.648 146.069 -66.828  1.00 59.00           C  
ATOM    101  C6    U B   5      40.245 145.227 -65.879  1.00 59.47           C  
ATOM    102  P     U B   6      38.768 142.388 -59.610  1.00 64.05           P  
ATOM    103  OP1   U B   6      37.461 141.934 -60.152  1.00 65.24           O  
ATOM    104  OP2   U B   6      38.817 143.525 -58.660  1.00 64.73           O  
ATOM    105  O5'   U B   6      39.468 141.142 -58.913  1.00 63.77           O  
ATOM    106  C5'   U B   6      39.194 139.827 -59.366  1.00 68.33           C  
ATOM    107  C4'   U B   6      40.467 139.031 -59.486  1.00 71.18           C  
ATOM    108  O4'   U B   6      41.322 139.615 -60.499  1.00 70.15           O  
ATOM    109  C3'   U B   6      41.345 138.985 -58.252  1.00 73.74           C  
ATOM    110  O3'   U B   6      40.885 137.993 -57.355  1.00 79.65           O  
ATOM    111  C2'   U B   6      42.700 138.614 -58.840  1.00 72.80           C  
ATOM    112  O2'   U B   6      42.818 137.236 -59.135  1.00 73.11           O  
ATOM    113  C1'   U B   6      42.680 139.396 -60.152  1.00 70.03           C  
ATOM    114  N1    U B   6      43.362 140.696 -60.087  1.00 67.79           N  
ATOM    115  C2    U B   6      44.739 140.695 -60.131  1.00 67.39           C  
ATOM    116  O2    U B   6      45.396 139.668 -60.142  1.00 71.44           O  
ATOM    117  N3    U B   6      45.319 141.938 -60.159  1.00 65.11           N  
ATOM    118  C4    U B   6      44.672 143.153 -60.130  1.00 64.21           C  
ATOM    119  O4    U B   6      45.325 144.192 -60.207  1.00 62.53           O  
ATOM    120  C5    U B   6      43.253 143.066 -60.040  1.00 64.73           C  
ATOM    121  C6    U B   6      42.660 141.870 -60.021  1.00 65.84           C  
ATOM    122  P     U B   7      41.487 137.932 -55.874  1.00 86.35           P  
ATOM    123  OP1   U B   7      40.470 137.250 -55.030  1.00 86.50           O  
ATOM    124  OP2   U B   7      41.960 139.294 -55.509  1.00 85.79           O  
ATOM    125  O5'   U B   7      42.764 136.981 -56.000  1.00 89.80           O  
ATOM    126  C5'   U B   7      43.757 136.936 -54.972  1.00 94.24           C  
ATOM    127  C4'   U B   7      44.881 135.997 -55.361  1.00 97.65           C  
ATOM    128  O4'   U B   7      45.393 136.371 -56.673  1.00 99.66           O  
ATOM    129  C3'   U B   7      46.105 136.038 -54.453  1.00 99.38           C  
ATOM    130  O3'   U B   7      45.960 135.355 -53.188  1.00 98.73           O  
ATOM    131  C2'   U B   7      47.220 135.552 -55.378  1.00 99.73           C  
ATOM    132  O2'   U B   7      47.263 134.144 -55.523  1.00 99.22           O  
ATOM    133  C1'   U B   7      46.805 136.189 -56.711  1.00 99.73           C  
ATOM    134  N1    U B   7      47.440 137.489 -56.999  1.00 99.73           N  
ATOM    135  C2    U B   7      48.810 137.505 -57.264  1.00 99.73           C  
ATOM    136  O2    U B   7      49.501 136.496 -57.260  1.00 99.73           O  
ATOM    137  N3    U B   7      49.337 138.747 -57.537  1.00 99.73           N  
ATOM    138  C4    U B   7      48.658 139.953 -57.575  1.00 99.73           C  
ATOM    139  O4    U B   7      49.275 140.989 -57.850  1.00 99.73           O  
ATOM    140  C5    U B   7      47.252 139.859 -57.287  1.00 99.73           C  
ATOM    141  C6    U B   7      46.706 138.663 -57.015  1.00 99.73           C  
TER     142        U B   7                                                      
ATOM    143  N   LEU A 145      55.726 145.528 -56.466  1.00 87.11           N  
ATOM    144  CA  LEU A 145      55.616 144.085 -56.101  1.00 86.27           C  
ATOM    145  C   LEU A 145      55.730 143.193 -57.339  1.00 85.86           C  
ATOM    146  O   LEU A 145      56.683 143.313 -58.115  1.00 85.67           O  
ATOM    147  CB  LEU A 145      54.288 143.821 -55.368  1.00 86.64           C  
ATOM    148  CG  LEU A 145      52.986 144.391 -55.955  1.00 85.55           C  
ATOM    149  CD1 LEU A 145      51.793 143.562 -55.514  1.00 84.97           C  
ATOM    150  CD2 LEU A 145      52.817 145.845 -55.545  1.00 85.40           C  
ATOM    151  N   GLY A 146      54.764 142.288 -57.495  1.00 84.51           N  
ATOM    152  CA  GLY A 146      54.734 141.388 -58.631  1.00 81.33           C  
ATOM    153  C   GLY A 146      53.644 141.755 -59.622  1.00 79.62           C  
ATOM    154  O   GLY A 146      53.243 140.926 -60.433  1.00 80.65           O  
ATOM    155  N   SER A 147      53.131 142.980 -59.529  1.00 77.54           N  
ATOM    156  CA  SER A 147      52.089 143.457 -60.434  1.00 74.76           C  
ATOM    157  C   SER A 147      52.688 143.934 -61.746  1.00 73.19           C  
ATOM    158  O   SER A 147      51.984 144.108 -62.746  1.00 73.26           O  
ATOM    159  CB  SER A 147      51.293 144.571 -59.778  1.00 76.05           C  
ATOM    160  OG  SER A 147      50.504 144.027 -58.739  1.00 80.95           O  
ATOM    161  N   ALA A 148      53.995 144.166 -61.724  1.00 70.57           N  
ATOM    162  CA  ALA A 148      54.723 144.585 -62.907  1.00 67.06           C  
ATOM    163  C   ALA A 148      55.071 143.334 -63.701  1.00 65.37           C  
ATOM    164  O   ALA A 148      55.804 143.398 -64.688  1.00 65.17           O  
ATOM    165  CB  ALA A 148      55.978 145.303 -62.505  1.00 68.18           C  
ATOM    166  N   ARG A 149      54.560 142.194 -63.241  1.00 62.95           N  
ATOM    167  CA  ARG A 149      54.800 140.917 -63.890  1.00 61.95           C  
ATOM    168  C   ARG A 149      53.533 140.182 -64.318  1.00 61.00           C  
ATOM    169  O   ARG A 149      53.601 139.040 -64.785  1.00 59.86           O  
ATOM    170  CB  ARG A 149      55.675 140.022 -63.013  1.00 61.75           C  
ATOM    171  CG  ARG A 149      57.145 140.412 -63.047  1.00 63.56           C  
ATOM    172  CD  ARG A 149      58.039 139.352 -62.425  1.00 65.53           C  
ATOM    173  NE  ARG A 149      57.905 139.299 -60.974  1.00 69.22           N  
ATOM    174  CZ  ARG A 149      58.753 138.674 -60.160  1.00 71.85           C  
ATOM    175  NH1 ARG A 149      59.812 138.032 -60.643  1.00 72.27           N  
ATOM    176  NH2 ARG A 149      58.545 138.698 -58.851  1.00 74.14           N  
ATOM    177  N   ARG A 150      52.385 140.849 -64.184  1.00 59.20           N  
ATOM    178  CA  ARG A 150      51.099 140.268 -64.577  1.00 57.68           C  
ATOM    179  C   ARG A 150      50.419 141.170 -65.605  1.00 56.35           C  
ATOM    180  O   ARG A 150      50.760 142.342 -65.732  1.00 56.69           O  
ATOM    181  CB  ARG A 150      50.166 140.106 -63.368  1.00 58.50           C  
ATOM    182  CG  ARG A 150      50.847 139.674 -62.075  1.00 60.66           C  
ATOM    183  CD  ARG A 150      49.853 139.125 -61.063  1.00 62.03           C  
ATOM    184  NE  ARG A 150      49.930 137.665 -60.980  1.00 64.83           N  
ATOM    185  CZ  ARG A 150      48.877 136.852 -60.873  1.00 65.86           C  
ATOM    186  NH1 ARG A 150      47.642 137.346 -60.824  1.00 65.60           N  
ATOM    187  NH2 ARG A 150      49.059 135.535 -60.868  1.00 64.58           N  
ATOM    188  N   LEU A 151      49.514 140.603 -66.392  1.00 55.33           N  
ATOM    189  CA  LEU A 151      48.768 141.388 -67.372  1.00 54.76           C  
ATOM    190  C   LEU A 151      47.315 140.929 -67.421  1.00 53.80           C  
ATOM    191  O   LEU A 151      47.007 139.753 -67.256  1.00 53.34           O  
ATOM    192  CB  LEU A 151      49.374 141.285 -68.776  1.00 54.64           C  
ATOM    193  CG  LEU A 151      50.656 142.030 -69.152  1.00 56.08           C  
ATOM    194  CD1 LEU A 151      50.884 141.924 -70.650  1.00 52.72           C  
ATOM    195  CD2 LEU A 151      50.558 143.490 -68.752  1.00 58.53           C  
ATOM    196  N   TYR A 152      46.416 141.883 -67.575  1.00 54.18           N  
ATOM    197  CA  TYR A 152      45.003 141.575 -67.684  1.00 54.04           C  
ATOM    198  C   TYR A 152      44.699 141.413 -69.167  1.00 54.54           C  
ATOM    199  O   TYR A 152      45.091 142.240 -70.000  1.00 54.16           O  
ATOM    200  CB  TYR A 152      44.154 142.717 -67.104  1.00 55.57           C  
ATOM    201  CG  TYR A 152      42.697 142.711 -67.550  1.00 56.88           C  
ATOM    202  CD1 TYR A 152      42.306 143.358 -68.719  1.00 55.82           C  
ATOM    203  CD2 TYR A 152      41.721 142.034 -66.823  1.00 58.14           C  
ATOM    204  CE1 TYR A 152      41.002 143.326 -69.156  1.00 55.99           C  
ATOM    205  CE2 TYR A 152      40.400 142.000 -67.256  1.00 58.60           C  
ATOM    206  CZ  TYR A 152      40.052 142.647 -68.428  1.00 58.56           C  
ATOM    207  OH  TYR A 152      38.756 142.595 -68.899  1.00 61.35           O  
ATOM    208  N   VAL A 153      44.035 140.321 -69.506  1.00 54.30           N  
ATOM    209  CA  VAL A 153      43.648 140.098 -70.884  1.00 53.42           C  
ATOM    210  C   VAL A 153      42.162 139.777 -70.875  1.00 53.68           C  
ATOM    211  O   VAL A 153      41.730 138.748 -70.354  1.00 54.40           O  
ATOM    212  CB  VAL A 153      44.505 138.996 -71.573  1.00 54.22           C  
ATOM    213  CG1 VAL A 153      44.762 137.839 -70.628  1.00 55.80           C  
ATOM    214  CG2 VAL A 153      43.835 138.518 -72.860  1.00 51.30           C  
ATOM    215  N   GLY A 154      41.377 140.737 -71.342  1.00 52.86           N  
ATOM    216  CA  GLY A 154      39.944 140.553 -71.391  1.00 53.26           C  
ATOM    217  C   GLY A 154      39.455 140.234 -72.789  1.00 53.65           C  
ATOM    218  O   GLY A 154      40.206 140.378 -73.767  1.00 52.77           O  
ATOM    219  N   ASN A 155      38.180 139.840 -72.868  1.00 52.22           N  
ATOM    220  CA  ASN A 155      37.516 139.479 -74.114  1.00 52.32           C  
ATOM    221  C   ASN A 155      38.089 138.174 -74.662  1.00 52.66           C  
ATOM    222  O   ASN A 155      38.279 138.014 -75.870  1.00 53.06           O  
ATOM    223  CB  ASN A 155      37.650 140.605 -75.140  1.00 52.64           C  
ATOM    224  CG  ASN A 155      36.822 140.361 -76.377  1.00 53.26           C  
ATOM    225  OD1 ASN A 155      37.336 140.373 -77.492  1.00 56.96           O  
ATOM    226  ND2 ASN A 155      35.535 140.113 -76.187  1.00 55.82           N  
ATOM    227  N   ILE A 156      38.348 137.234 -73.761  1.00 52.31           N  
ATOM    228  CA  ILE A 156      38.910 135.951 -74.145  1.00 52.38           C  
ATOM    229  C   ILE A 156      37.856 135.051 -74.756  1.00 53.62           C  
ATOM    230  O   ILE A 156      36.670 135.199 -74.460  1.00 55.22           O  
ATOM    231  CB  ILE A 156      39.551 135.231 -72.939  1.00 50.56           C  
ATOM    232  CG1 ILE A 156      38.508 134.952 -71.870  1.00 48.03           C  
ATOM    233  CG2 ILE A 156      40.647 136.091 -72.341  1.00 54.16           C  
ATOM    234  CD1 ILE A 156      39.048 134.194 -70.699  1.00 47.47           C  
ATOM    235  N   PRO A 157      38.264 134.149 -75.669  1.00 53.82           N  
ATOM    236  CA  PRO A 157      37.352 133.216 -76.325  1.00 52.98           C  
ATOM    237  C   PRO A 157      36.664 132.363 -75.270  1.00 53.62           C  
ATOM    238  O   PRO A 157      37.270 132.006 -74.245  1.00 50.88           O  
ATOM    239  CB  PRO A 157      38.296 132.368 -77.171  1.00 53.94           C  
ATOM    240  CG  PRO A 157      39.325 133.324 -77.556  1.00 54.96           C  
ATOM    241  CD  PRO A 157      39.609 134.026 -76.250  1.00 55.19           C  
ATOM    242  N   PHE A 158      35.399 132.038 -75.524  1.00 53.46           N  
ATOM    243  CA  PHE A 158      34.635 131.229 -74.590  1.00 54.19           C  
ATOM    244  C   PHE A 158      35.181 129.813 -74.454  1.00 54.45           C  
ATOM    245  O   PHE A 158      35.566 129.185 -75.446  1.00 54.98           O  
ATOM    246  CB  PHE A 158      33.168 131.169 -75.007  1.00 56.44           C  
ATOM    247  CG  PHE A 158      32.289 130.495 -73.998  1.00 56.35           C  
ATOM    248  CD1 PHE A 158      32.062 131.083 -72.763  1.00 57.36           C  
ATOM    249  CD2 PHE A 158      31.718 129.260 -74.269  1.00 58.05           C  
ATOM    250  CE1 PHE A 158      31.284 130.458 -71.807  1.00 58.61           C  
ATOM    251  CE2 PHE A 158      30.930 128.620 -73.315  1.00 60.34           C  
ATOM    252  CZ  PHE A 158      30.715 129.225 -72.076  1.00 58.83           C  
ATOM    253  N   GLY A 159      35.234 129.329 -73.215  1.00 53.54           N  
ATOM    254  CA  GLY A 159      35.711 127.980 -72.970  1.00 53.18           C  
ATOM    255  C   GLY A 159      37.166 127.707 -73.300  1.00 52.79           C  
ATOM    256  O   GLY A 159      37.573 126.549 -73.400  1.00 54.05           O  
ATOM    257  N   ILE A 160      37.945 128.758 -73.523  1.00 52.31           N  
ATOM    258  CA  ILE A 160      39.364 128.589 -73.804  1.00 52.53           C  
ATOM    259  C   ILE A 160      40.001 128.033 -72.521  1.00 53.86           C  
ATOM    260  O   ILE A 160      39.574 128.387 -71.410  1.00 53.03           O  
ATOM    261  CB  ILE A 160      40.017 129.934 -74.152  1.00 51.88           C  
ATOM    262  CG1 ILE A 160      41.417 129.712 -74.692  1.00 49.43           C  
ATOM    263  CG2 ILE A 160      40.075 130.834 -72.930  1.00 52.04           C  
ATOM    264  CD1 ILE A 160      41.417 129.005 -75.988  1.00 54.00           C  
ATOM    265  N   THR A 161      40.958 127.117 -72.667  1.00 53.43           N  
ATOM    266  CA  THR A 161      41.622 126.547 -71.498  1.00 54.61           C  
ATOM    267  C   THR A 161      42.783 127.436 -71.105  1.00 53.92           C  
ATOM    268  O   THR A 161      43.330 128.156 -71.940  1.00 53.29           O  
ATOM    269  CB  THR A 161      42.175 125.119 -71.750  1.00 56.07           C  
ATOM    270  OG1 THR A 161      43.255 125.161 -72.694  1.00 57.63           O  
ATOM    271  CG2 THR A 161      41.089 124.219 -72.278  1.00 57.17           C  
ATOM    272  N   GLU A 162      43.156 127.388 -69.832  1.00 53.73           N  
ATOM    273  CA  GLU A 162      44.272 128.183 -69.349  1.00 54.48           C  
ATOM    274  C   GLU A 162      45.549 127.808 -70.091  1.00 54.64           C  
ATOM    275  O   GLU A 162      46.334 128.684 -70.467  1.00 53.90           O  
ATOM    276  CB  GLU A 162      44.444 127.997 -67.850  1.00 54.43           C  
ATOM    277  CG  GLU A 162      43.252 128.502 -67.060  1.00 57.03           C  
ATOM    278  CD  GLU A 162      43.432 128.357 -65.560  1.00 58.20           C  
ATOM    279  OE1 GLU A 162      42.986 129.263 -64.820  1.00 55.57           O  
ATOM    280  OE2 GLU A 162      44.011 127.334 -65.128  1.00 59.48           O  
ATOM    281  N   GLU A 163      45.707 126.514 -70.370  1.00 53.90           N  
ATOM    282  CA  GLU A 163      46.881 126.035 -71.081  1.00 54.83           C  
ATOM    283  C   GLU A 163      46.944 126.549 -72.516  1.00 53.91           C  
ATOM    284  O   GLU A 163      48.015 126.892 -72.999  1.00 54.22           O  
ATOM    285  CB  GLU A 163      46.955 124.508 -71.075  1.00 56.81           C  
ATOM    286  CG  GLU A 163      48.326 123.997 -71.509  1.00 60.38           C  
ATOM    287  CD  GLU A 163      48.379 122.508 -71.818  1.00 62.31           C  
ATOM    288  OE1 GLU A 163      47.318 121.846 -71.872  1.00 64.51           O  
ATOM    289  OE2 GLU A 163      49.501 122.000 -72.031  1.00 62.95           O  
ATOM    290  N   ALA A 164      45.803 126.613 -73.193  1.00 54.52           N  
ATOM    291  CA  ALA A 164      45.765 127.094 -74.575  1.00 53.78           C  
ATOM    292  C   ALA A 164      46.181 128.550 -74.623  1.00 54.73           C  
ATOM    293  O   ALA A 164      46.804 129.007 -75.576  1.00 54.94           O  
ATOM    294  CB  ALA A 164      44.384 126.942 -75.138  1.00 53.07           C  
ATOM    295  N   MET A 165      45.832 129.270 -73.566  1.00 56.31           N  
ATOM    296  CA  MET A 165      46.149 130.681 -73.438  1.00 55.71           C  
ATOM    297  C   MET A 165      47.661 130.822 -73.310  1.00 54.78           C  
ATOM    298  O   MET A 165      48.283 131.602 -74.025  1.00 55.83           O  
ATOM    299  CB  MET A 165      45.484 131.215 -72.175  1.00 58.31           C  
ATOM    300  CG  MET A 165      45.089 132.672 -72.213  1.00 60.60           C  
ATOM    301  SD  MET A 165      43.574 132.906 -73.130  1.00 60.12           S  
ATOM    302  CE  MET A 165      44.173 133.889 -74.497  1.00 62.38           C  
ATOM    303  N   MET A 166      48.244 130.023 -72.420  1.00 53.51           N  
ATOM    304  CA  MET A 166      49.676 130.048 -72.168  1.00 52.26           C  
ATOM    305  C   MET A 166      50.464 129.716 -73.421  1.00 52.73           C  
ATOM    306  O   MET A 166      51.380 130.444 -73.802  1.00 54.42           O  
ATOM    307  CB  MET A 166      50.026 129.060 -71.067  1.00 51.21           C  
ATOM    308  CG  MET A 166      51.296 129.396 -70.330  1.00 52.43           C  
ATOM    309  SD  MET A 166      51.575 128.327 -68.896  1.00 51.54           S  
ATOM    310  CE  MET A 166      53.196 127.773 -69.238  1.00 54.81           C  
ATOM    311  N   ASP A 167      50.094 128.625 -74.075  1.00 51.21           N  
ATOM    312  CA  ASP A 167      50.772 128.207 -75.291  1.00 50.62           C  
ATOM    313  C   ASP A 167      50.716 129.286 -76.374  1.00 49.75           C  
ATOM    314  O   ASP A 167      51.692 129.499 -77.088  1.00 50.01           O  
ATOM    315  CB  ASP A 167      50.173 126.891 -75.811  1.00 51.49           C  
ATOM    316  CG  ASP A 167      50.276 125.748 -74.799  1.00 52.99           C  
ATOM    317  OD1 ASP A 167      51.078 125.847 -73.837  1.00 53.60           O  
ATOM    318  OD2 ASP A 167      49.542 124.746 -74.965  1.00 54.83           O  
ATOM    319  N   PHE A 168      49.585 129.979 -76.477  1.00 49.39           N  
ATOM    320  CA  PHE A 168      49.414 131.033 -77.471  1.00 47.83           C  
ATOM    321  C   PHE A 168      50.351 132.189 -77.210  1.00 48.54           C  
ATOM    322  O   PHE A 168      51.009 132.686 -78.122  1.00 49.17           O  
ATOM    323  CB  PHE A 168      47.990 131.559 -77.455  1.00 47.50           C  
ATOM    324  CG  PHE A 168      47.718 132.600 -78.500  1.00 47.99           C  
ATOM    325  CD1 PHE A 168      47.688 132.265 -79.849  1.00 48.90           C  
ATOM    326  CD2 PHE A 168      47.470 133.912 -78.140  1.00 49.13           C  
ATOM    327  CE1 PHE A 168      47.413 133.221 -80.810  1.00 46.55           C  
ATOM    328  CE2 PHE A 168      47.194 134.874 -79.104  1.00 48.64           C  
ATOM    329  CZ  PHE A 168      47.166 134.524 -80.434  1.00 46.37           C  
ATOM    330  N   PHE A 169      50.412 132.628 -75.961  1.00 48.95           N  
ATOM    331  CA  PHE A 169      51.287 133.739 -75.634  1.00 48.41           C  
ATOM    332  C   PHE A 169      52.778 133.448 -75.651  1.00 47.41           C  
ATOM    333  O   PHE A 169      53.547 134.282 -76.111  1.00 48.03           O  
ATOM    334  CB  PHE A 169      50.848 134.414 -74.352  1.00 46.51           C  
ATOM    335  CG  PHE A 169      49.690 135.333 -74.548  1.00 47.75           C  
ATOM    336  CD1 PHE A 169      48.394 134.894 -74.332  1.00 47.99           C  
ATOM    337  CD2 PHE A 169      49.894 136.639 -74.958  1.00 46.25           C  
ATOM    338  CE1 PHE A 169      47.331 135.741 -74.515  1.00 47.57           C  
ATOM    339  CE2 PHE A 169      48.832 137.490 -75.141  1.00 45.86           C  
ATOM    340  CZ  PHE A 169      47.549 137.043 -74.922  1.00 47.04           C  
ATOM    341  N   ASN A 170      53.196 132.282 -75.168  1.00 46.83           N  
ATOM    342  CA  ASN A 170      54.613 131.938 -75.218  1.00 47.22           C  
ATOM    343  C   ASN A 170      55.033 131.840 -76.683  1.00 47.44           C  
ATOM    344  O   ASN A 170      56.111 132.285 -77.072  1.00 48.16           O  
ATOM    345  CB  ASN A 170      54.884 130.622 -74.496  1.00 47.89           C  
ATOM    346  CG  ASN A 170      55.087 130.813 -73.006  1.00 48.68           C  
ATOM    347  OD1 ASN A 170      55.590 131.847 -72.577  1.00 49.20           O  
ATOM    348  ND2 ASN A 170      54.689 129.823 -72.208  1.00 49.82           N  
ATOM    349  N   ALA A 171      54.136 131.331 -77.515  1.00 48.52           N  
ATOM    350  CA  ALA A 171      54.430 131.216 -78.931  1.00 48.15           C  
ATOM    351  C   ALA A 171      54.532 132.580 -79.599  1.00 47.57           C  
ATOM    352  O   ALA A 171      55.410 132.786 -80.427  1.00 49.18           O  
ATOM    353  CB  ALA A 171      53.397 130.375 -79.611  1.00 49.74           C  
ATOM    354  N   GLN A 172      53.647 133.512 -79.253  1.00 46.16           N  
ATOM    355  CA  GLN A 172      53.706 134.846 -79.862  1.00 47.39           C  
ATOM    356  C   GLN A 172      54.992 135.555 -79.501  1.00 46.08           C  
ATOM    357  O   GLN A 172      55.629 136.178 -80.347  1.00 46.73           O  
ATOM    358  CB  GLN A 172      52.519 135.709 -79.445  1.00 47.96           C  
ATOM    359  CG  GLN A 172      51.197 135.302 -80.072  1.00 49.01           C  
ATOM    360  CD  GLN A 172      51.172 135.486 -81.561  1.00 48.53           C  
ATOM    361  OE1 GLN A 172      50.383 134.854 -82.256  1.00 50.98           O  
ATOM    362  NE2 GLN A 172      52.025 136.364 -82.065  1.00 48.98           N  
ATOM    363  N   MET A 173      55.356 135.431 -78.232  1.00 46.70           N  
ATOM    364  CA  MET A 173      56.565 136.002 -77.657  1.00 47.68           C  
ATOM    365  C   MET A 173      57.828 135.494 -78.349  1.00 49.31           C  
ATOM    366  O   MET A 173      58.818 136.210 -78.436  1.00 49.17           O  
ATOM    367  CB  MET A 173      56.630 135.629 -76.177  1.00 48.75           C  
ATOM    368  CG  MET A 173      55.683 136.398 -75.292  1.00 50.05           C  
ATOM    369  SD  MET A 173      56.346 137.998 -74.895  1.00 53.09           S  
ATOM    370  CE  MET A 173      55.590 138.954 -76.054  1.00 52.57           C  
ATOM    371  N   ARG A 174      57.799 134.232 -78.773  1.00 52.51           N  
ATOM    372  CA  ARG A 174      58.918 133.611 -79.466  1.00 54.41           C  
ATOM    373  C   ARG A 174      58.931 133.958 -80.951  1.00 53.32           C  
ATOM    374  O   ARG A 174      59.990 134.209 -81.520  1.00 54.04           O  
ATOM    375  CB  ARG A 174      58.873 132.088 -79.302  1.00 58.59           C  
ATOM    376  CG  ARG A 174      59.073 131.619 -77.874  1.00 63.09           C  
ATOM    377  CD  ARG A 174      59.424 130.131 -77.801  1.00 68.32           C  
ATOM    378  NE  ARG A 174      60.019 129.803 -76.501  1.00 72.85           N  
ATOM    379  CZ  ARG A 174      61.265 129.367 -76.319  1.00 73.91           C  
ATOM    380  NH1 ARG A 174      62.080 129.182 -77.354  1.00 74.18           N  
ATOM    381  NH2 ARG A 174      61.717 129.163 -75.089  1.00 76.54           N  
ATOM    382  N   LEU A 175      57.758 133.972 -81.574  1.00 52.65           N  
ATOM    383  CA  LEU A 175      57.657 134.284 -82.991  1.00 54.10           C  
ATOM    384  C   LEU A 175      58.052 135.711 -83.274  1.00 55.00           C  
ATOM    385  O   LEU A 175      58.450 136.024 -84.395  1.00 57.93           O  
ATOM    386  CB  LEU A 175      56.241 134.075 -83.516  1.00 55.82           C  
ATOM    387  CG  LEU A 175      55.794 132.692 -83.966  1.00 57.14           C  
ATOM    388  CD1 LEU A 175      54.400 132.788 -84.537  1.00 59.90           C  
ATOM    389  CD2 LEU A 175      56.730 132.177 -85.023  1.00 60.31           C  
ATOM    390  N   GLY A 176      57.904 136.582 -82.279  1.00 53.35           N  
ATOM    391  CA  GLY A 176      58.251 137.977 -82.474  1.00 52.98           C  
ATOM    392  C   GLY A 176      59.653 138.337 -82.033  1.00 52.47           C  
ATOM    393  O   GLY A 176      60.153 139.415 -82.355  1.00 52.16           O  
ATOM    394  N   GLY A 177      60.302 137.415 -81.330  1.00 51.76           N  
ATOM    395  CA  GLY A 177      61.642 137.658 -80.826  1.00 51.21           C  
ATOM    396  C   GLY A 177      61.598 138.616 -79.654  1.00 50.69           C  
ATOM    397  O   GLY A 177      62.542 139.365 -79.413  1.00 51.27           O  
ATOM    398  N   LEU A 178      60.504 138.557 -78.903  1.00 50.41           N  
ATOM    399  CA  LEU A 178      60.297 139.436 -77.767  1.00 50.84           C  
ATOM    400  C   LEU A 178      60.819 138.959 -76.430  1.00 51.13           C  
ATOM    401  O   LEU A 178      60.698 139.674 -75.444  1.00 52.45           O  
ATOM    402  CB  LEU A 178      58.818 139.807 -77.658  1.00 51.88           C  
ATOM    403  CG  LEU A 178      58.309 140.968 -78.532  1.00 51.91           C  
ATOM    404  CD1 LEU A 178      58.831 140.886 -79.961  1.00 51.42           C  
ATOM    405  CD2 LEU A 178      56.787 141.003 -78.514  1.00 51.18           C  
ATOM    406  N   THR A 179      61.418 137.773 -76.385  1.00 52.40           N  
ATOM    407  CA  THR A 179      61.965 137.249 -75.128  1.00 52.10           C  
ATOM    408  C   THR A 179      63.373 137.785 -74.822  1.00 53.16           C  
ATOM    409  O   THR A 179      64.159 138.042 -75.738  1.00 53.25           O  
ATOM    410  CB  THR A 179      62.016 135.740 -75.150  1.00 50.28           C  
ATOM    411  OG1 THR A 179      62.836 135.319 -76.237  1.00 52.29           O  
ATOM    412  CG2 THR A 179      60.643 135.180 -75.340  1.00 50.85           C  
ATOM    413  N   GLN A 180      63.685 137.949 -73.536  1.00 53.97           N  
ATOM    414  CA  GLN A 180      64.990 138.464 -73.130  1.00 54.40           C  
ATOM    415  C   GLN A 180      66.043 137.409 -72.835  1.00 55.60           C  
ATOM    416  O   GLN A 180      67.242 137.681 -72.915  1.00 58.68           O  
ATOM    417  CB  GLN A 180      64.866 139.426 -71.949  1.00 54.10           C  
ATOM    418  CG  GLN A 180      64.263 138.864 -70.683  1.00 56.04           C  
ATOM    419  CD  GLN A 180      64.018 139.952 -69.629  1.00 57.85           C  
ATOM    420  OE1 GLN A 180      64.137 139.711 -68.426  1.00 60.47           O  
ATOM    421  NE2 GLN A 180      63.677 141.155 -70.085  1.00 59.04           N  
ATOM    422  N   ALA A 181      65.600 136.200 -72.525  1.00 55.13           N  
ATOM    423  CA  ALA A 181      66.503 135.108 -72.221  1.00 52.66           C  
ATOM    424  C   ALA A 181      65.887 133.817 -72.728  1.00 52.99           C  
ATOM    425  O   ALA A 181      64.750 133.801 -73.186  1.00 53.31           O  
ATOM    426  CB  ALA A 181      66.731 135.041 -70.734  1.00 52.60           C  
ATOM    427  N   PRO A 182      66.658 132.726 -72.733  1.00 53.90           N  
ATOM    428  CA  PRO A 182      66.060 131.481 -73.218  1.00 54.92           C  
ATOM    429  C   PRO A 182      64.915 131.052 -72.297  1.00 55.67           C  
ATOM    430  O   PRO A 182      64.854 131.476 -71.136  1.00 53.54           O  
ATOM    431  CB  PRO A 182      67.229 130.500 -73.156  1.00 54.32           C  
ATOM    432  CG  PRO A 182      68.418 131.384 -73.390  1.00 54.55           C  
ATOM    433  CD  PRO A 182      68.108 132.572 -72.525  1.00 53.03           C  
ATOM    434  N   GLY A 183      63.991 130.258 -72.839  1.00 55.52           N  
ATOM    435  CA  GLY A 183      62.866 129.784 -72.055  1.00 55.32           C  
ATOM    436  C   GLY A 183      61.640 130.657 -72.178  1.00 54.62           C  
ATOM    437  O   GLY A 183      61.747 131.827 -72.526  1.00 55.25           O  
ATOM    438  N   ASN A 184      60.486 130.089 -71.834  1.00 55.53           N  
ATOM    439  CA  ASN A 184      59.189 130.770 -71.909  1.00 53.67           C  
ATOM    440  C   ASN A 184      58.985 131.906 -70.926  1.00 53.45           C  
ATOM    441  O   ASN A 184      59.302 131.782 -69.746  1.00 54.97           O  
ATOM    442  CB  ASN A 184      58.057 129.772 -71.685  1.00 52.54           C  
ATOM    443  CG  ASN A 184      57.958 128.735 -72.771  1.00 52.84           C  
ATOM    444  OD1 ASN A 184      58.444 128.919 -73.892  1.00 54.83           O  
ATOM    445  ND2 ASN A 184      57.299 127.631 -72.450  1.00 56.15           N  
ATOM    446  N   PRO A 185      58.411 133.021 -71.395  1.00 53.50           N  
ATOM    447  CA  PRO A 185      58.152 134.180 -70.539  1.00 52.73           C  
ATOM    448  C   PRO A 185      56.968 133.893 -69.625  1.00 52.89           C  
ATOM    449  O   PRO A 185      57.070 133.999 -68.407  1.00 53.60           O  
ATOM    450  CB  PRO A 185      57.782 135.261 -71.548  1.00 51.82           C  
ATOM    451  CG  PRO A 185      58.483 134.847 -72.767  1.00 51.39           C  
ATOM    452  CD  PRO A 185      58.221 133.384 -72.805  1.00 52.56           C  
ATOM    453  N   VAL A 186      55.846 133.526 -70.237  1.00 53.74           N  
ATOM    454  CA  VAL A 186      54.608 133.238 -69.523  1.00 53.45           C  
ATOM    455  C   VAL A 186      54.677 131.954 -68.704  1.00 54.20           C  
ATOM    456  O   VAL A 186      54.694 130.849 -69.251  1.00 54.81           O  
ATOM    457  CB  VAL A 186      53.425 133.154 -70.491  1.00 51.80           C  
ATOM    458  CG1 VAL A 186      52.123 133.141 -69.721  1.00 54.39           C  
ATOM    459  CG2 VAL A 186      53.459 134.311 -71.449  1.00 51.93           C  
ATOM    460  N   LEU A 187      54.666 132.127 -67.385  1.00 54.54           N  
ATOM    461  CA  LEU A 187      54.745 131.035 -66.424  1.00 55.47           C  
ATOM    462  C   LEU A 187      53.397 130.417 -66.133  1.00 56.03           C  
ATOM    463  O   LEU A 187      53.296 129.213 -65.943  1.00 58.79           O  
ATOM    464  CB  LEU A 187      55.334 131.543 -65.111  1.00 56.80           C  
ATOM    465  CG  LEU A 187      56.624 132.361 -65.214  1.00 57.76           C  
ATOM    466  CD1 LEU A 187      56.896 133.030 -63.892  1.00 61.47           C  
ATOM    467  CD2 LEU A 187      57.799 131.499 -65.633  1.00 57.38           C  
ATOM    468  N   ALA A 188      52.368 131.252 -66.046  1.00 56.76           N  
ATOM    469  CA  ALA A 188      51.021 130.777 -65.761  1.00 55.40           C  
ATOM    470  C   ALA A 188      49.979 131.750 -66.272  1.00 56.07           C  
ATOM    471  O   ALA A 188      50.297 132.884 -66.627  1.00 55.89           O  
ATOM    472  CB  ALA A 188      50.846 130.576 -64.274  1.00 56.89           C  
ATOM    473  N   VAL A 189      48.735 131.286 -66.330  1.00 56.10           N  
ATOM    474  CA  VAL A 189      47.622 132.108 -66.781  1.00 58.07           C  
ATOM    475  C   VAL A 189      46.323 131.598 -66.177  1.00 59.84           C  
ATOM    476  O   VAL A 189      45.905 130.480 -66.443  1.00 62.86           O  
ATOM    477  CB  VAL A 189      47.539 132.193 -68.345  1.00 57.72           C  
ATOM    478  CG1 VAL A 189      48.098 130.961 -68.974  1.00 59.13           C  
ATOM    479  CG2 VAL A 189      46.096 132.410 -68.816  1.00 57.81           C  
ATOM    480  N   GLN A 190      45.712 132.417 -65.327  1.00 61.72           N  
ATOM    481  CA  GLN A 190      44.458 132.067 -64.666  1.00 62.77           C  
ATOM    482  C   GLN A 190      43.257 132.704 -65.360  1.00 61.74           C  
ATOM    483  O   GLN A 190      43.243 133.909 -65.614  1.00 59.73           O  
ATOM    484  CB  GLN A 190      44.496 132.522 -63.221  1.00 66.22           C  
ATOM    485  CG  GLN A 190      45.739 132.107 -62.493  1.00 72.22           C  
ATOM    486  CD  GLN A 190      46.042 133.049 -61.354  1.00 77.84           C  
ATOM    487  OE1 GLN A 190      46.553 134.162 -61.570  1.00 79.98           O  
ATOM    488  NE2 GLN A 190      45.697 132.634 -60.131  1.00 79.65           N  
ATOM    489  N   ILE A 191      42.238 131.889 -65.629  1.00 61.61           N  
ATOM    490  CA  ILE A 191      41.026 132.351 -66.303  1.00 60.68           C  
ATOM    491  C   ILE A 191      39.797 132.387 -65.405  1.00 60.89           C  
ATOM    492  O   ILE A 191      39.559 131.468 -64.639  1.00 62.58           O  
ATOM    493  CB  ILE A 191      40.699 131.461 -67.528  1.00 59.33           C  
ATOM    494  CG1 ILE A 191      41.773 131.625 -68.601  1.00 56.72           C  
ATOM    495  CG2 ILE A 191      39.332 131.810 -68.097  1.00 57.20           C  
ATOM    496  CD1 ILE A 191      41.592 130.710 -69.757  1.00 54.58           C  
ATOM    497  N   ASN A 192      39.051 133.482 -65.482  1.00 61.46           N  
ATOM    498  CA  ASN A 192      37.808 133.656 -64.740  1.00 61.82           C  
ATOM    499  C   ASN A 192      36.813 133.587 -65.885  1.00 62.61           C  
ATOM    500  O   ASN A 192      36.471 134.612 -66.482  1.00 63.17           O  
ATOM    501  CB  ASN A 192      37.769 135.043 -64.094  1.00 62.15           C  
ATOM    502  CG  ASN A 192      36.588 135.228 -63.165  1.00 61.14           C  
ATOM    503  OD1 ASN A 192      35.462 134.857 -63.480  1.00 62.25           O  
ATOM    504  ND2 ASN A 192      36.843 135.818 -62.013  1.00 62.39           N  
ATOM    505  N   GLN A 193      36.371 132.373 -66.205  1.00 64.27           N  
ATOM    506  CA  GLN A 193      35.473 132.167 -67.335  1.00 67.05           C  
ATOM    507  C   GLN A 193      34.217 133.033 -67.393  1.00 67.32           C  
ATOM    508  O   GLN A 193      33.938 133.638 -68.432  1.00 67.97           O  
ATOM    509  CB  GLN A 193      35.134 130.683 -67.529  1.00 68.72           C  
ATOM    510  CG  GLN A 193      35.015 130.301 -69.018  1.00 75.04           C  
ATOM    511  CD  GLN A 193      34.261 128.990 -69.266  1.00 79.31           C  
ATOM    512  OE1 GLN A 193      33.146 128.991 -69.803  1.00 80.36           O  
ATOM    513  NE2 GLN A 193      34.876 127.868 -68.891  1.00 80.86           N  
ATOM    514  N   ASP A 194      33.478 133.138 -66.295  1.00 67.68           N  
ATOM    515  CA  ASP A 194      32.274 133.955 -66.332  1.00 69.60           C  
ATOM    516  C   ASP A 194      32.547 135.426 -66.560  1.00 69.40           C  
ATOM    517  O   ASP A 194      31.819 136.092 -67.293  1.00 71.62           O  
ATOM    518  CB  ASP A 194      31.440 133.822 -65.067  1.00 71.39           C  
ATOM    519  CG  ASP A 194      30.187 134.696 -65.118  1.00 74.09           C  
ATOM    520  OD1 ASP A 194      29.311 134.440 -65.989  1.00 73.40           O  
ATOM    521  OD2 ASP A 194      30.104 135.663 -64.318  1.00 74.67           O  
ATOM    522  N   LYS A 195      33.575 135.942 -65.904  1.00 67.45           N  
ATOM    523  CA  LYS A 195      33.912 137.346 -66.033  1.00 62.85           C  
ATOM    524  C   LYS A 195      34.585 137.644 -67.361  1.00 61.88           C  
ATOM    525  O   LYS A 195      34.859 138.805 -67.683  1.00 59.64           O  
ATOM    526  CB  LYS A 195      34.770 137.775 -64.849  1.00 63.64           C  
ATOM    527  CG  LYS A 195      33.993 137.901 -63.553  1.00 64.79           C  
ATOM    528  CD  LYS A 195      33.526 139.334 -63.386  1.00 67.21           C  
ATOM    529  CE  LYS A 195      32.148 139.412 -62.779  1.00 68.89           C  
ATOM    530  NZ  LYS A 195      31.152 138.771 -63.685  1.00 69.41           N  
ATOM    531  N   ASN A 196      34.823 136.581 -68.131  1.00 60.10           N  
ATOM    532  CA  ASN A 196      35.439 136.660 -69.457  1.00 57.89           C  
ATOM    533  C   ASN A 196      36.823 137.313 -69.484  1.00 57.61           C  
ATOM    534  O   ASN A 196      37.115 138.146 -70.342  1.00 57.90           O  
ATOM    535  CB  ASN A 196      34.507 137.382 -70.428  1.00 55.82           C  
ATOM    536  CG  ASN A 196      34.967 137.277 -71.863  1.00 55.31           C  
ATOM    537  OD1 ASN A 196      34.996 138.267 -72.600  1.00 53.44           O  
ATOM    538  ND2 ASN A 196      35.338 136.073 -72.268  1.00 53.41           N  
ATOM    539  N   PHE A 197      37.687 136.915 -68.561  1.00 56.93           N  
ATOM    540  CA  PHE A 197      39.022 137.481 -68.532  1.00 57.83           C  
ATOM    541  C   PHE A 197      40.039 136.547 -67.904  1.00 56.66           C  
ATOM    542  O   PHE A 197      39.693 135.628 -67.156  1.00 55.58           O  
ATOM    543  CB  PHE A 197      39.028 138.852 -67.818  1.00 60.82           C  
ATOM    544  CG  PHE A 197      39.022 138.769 -66.311  1.00 62.51           C  
ATOM    545  CD1 PHE A 197      40.210 138.647 -65.601  1.00 62.99           C  
ATOM    546  CD2 PHE A 197      37.830 138.808 -65.602  1.00 64.25           C  
ATOM    547  CE1 PHE A 197      40.204 138.562 -64.216  1.00 63.49           C  
ATOM    548  CE2 PHE A 197      37.824 138.723 -64.208  1.00 63.76           C  
ATOM    549  CZ  PHE A 197      39.010 138.600 -63.521  1.00 62.88           C  
ATOM    550  N   ALA A 198      41.302 136.798 -68.217  1.00 55.52           N  
ATOM    551  CA  ALA A 198      42.391 136.009 -67.681  1.00 55.22           C  
ATOM    552  C   ALA A 198      43.532 136.939 -67.361  1.00 55.38           C  
ATOM    553  O   ALA A 198      43.580 138.075 -67.838  1.00 57.32           O  
ATOM    554  CB  ALA A 198      42.838 134.979 -68.682  1.00 54.38           C  
ATOM    555  N   PHE A 199      44.409 136.482 -66.482  1.00 56.42           N  
ATOM    556  CA  PHE A 199      45.593 137.244 -66.125  1.00 55.79           C  
ATOM    557  C   PHE A 199      46.797 136.401 -66.545  1.00 54.17           C  
ATOM    558  O   PHE A 199      46.766 135.182 -66.441  1.00 53.02           O  
ATOM    559  CB  PHE A 199      45.623 137.531 -64.628  1.00 56.65           C  
ATOM    560  CG  PHE A 199      45.026 138.855 -64.251  1.00 59.29           C  
ATOM    561  CD1 PHE A 199      45.843 139.934 -63.937  1.00 61.88           C  
ATOM    562  CD2 PHE A 199      43.648 139.025 -64.183  1.00 60.94           C  
ATOM    563  CE1 PHE A 199      45.296 141.164 -63.554  1.00 61.86           C  
ATOM    564  CE2 PHE A 199      43.092 140.251 -63.800  1.00 59.81           C  
ATOM    565  CZ  PHE A 199      43.919 141.318 -63.487  1.00 60.54           C  
ATOM    566  N   LEU A 200      47.807 137.040 -67.119  1.00 52.80           N  
ATOM    567  CA  LEU A 200      49.007 136.335 -67.535  1.00 53.47           C  
ATOM    568  C   LEU A 200      50.084 136.633 -66.515  1.00 55.44           C  
ATOM    569  O   LEU A 200      50.250 137.784 -66.102  1.00 57.03           O  
ATOM    570  CB  LEU A 200      49.485 136.831 -68.899  1.00 52.12           C  
ATOM    571  CG  LEU A 200      48.539 136.685 -70.076  1.00 51.83           C  
ATOM    572  CD1 LEU A 200      49.209 137.220 -71.322  1.00 51.26           C  
ATOM    573  CD2 LEU A 200      48.173 135.226 -70.242  1.00 53.49           C  
ATOM    574  N   GLU A 201      50.812 135.600 -66.108  1.00 57.15           N  
ATOM    575  CA  GLU A 201      51.889 135.766 -65.148  1.00 58.20           C  
ATOM    576  C   GLU A 201      53.210 135.555 -65.886  1.00 58.48           C  
ATOM    577  O   GLU A 201      53.409 134.524 -66.527  1.00 57.92           O  
ATOM    578  CB  GLU A 201      51.738 134.767 -64.006  1.00 60.29           C  
ATOM    579  CG  GLU A 201      52.668 135.017 -62.826  1.00 66.57           C  
ATOM    580  CD  GLU A 201      52.606 133.908 -61.767  1.00 71.44           C  
ATOM    581  OE1 GLU A 201      51.575 133.190 -61.690  1.00 72.95           O  
ATOM    582  OE2 GLU A 201      53.594 133.752 -61.009  1.00 74.40           O  
ATOM    583  N   PHE A 202      54.081 136.565 -65.833  1.00 58.55           N  
ATOM    584  CA  PHE A 202      55.385 136.524 -66.493  1.00 57.78           C  
ATOM    585  C   PHE A 202      56.534 136.320 -65.518  1.00 58.20           C  
ATOM    586  O   PHE A 202      56.396 136.560 -64.320  1.00 58.58           O  
ATOM    587  CB  PHE A 202      55.620 137.809 -67.265  1.00 55.65           C  
ATOM    588  CG  PHE A 202      54.722 137.976 -68.437  1.00 56.02           C  
ATOM    589  CD1 PHE A 202      55.159 137.633 -69.715  1.00 55.95           C  
ATOM    590  CD2 PHE A 202      53.450 138.514 -68.280  1.00 55.86           C  
ATOM    591  CE1 PHE A 202      54.346 137.831 -70.819  1.00 54.89           C  
ATOM    592  CE2 PHE A 202      52.629 138.715 -69.378  1.00 55.53           C  
ATOM    593  CZ  PHE A 202      53.077 138.376 -70.650  1.00 54.66           C  
ATOM    594  N   ARG A 203      57.681 135.915 -66.051  1.00 57.56           N  
ATOM    595  CA  ARG A 203      58.861 135.668 -65.233  1.00 57.26           C  
ATOM    596  C   ARG A 203      59.672 136.925 -65.039  1.00 57.75           C  
ATOM    597  O   ARG A 203      60.467 137.018 -64.099  1.00 58.68           O  
ATOM    598  CB  ARG A 203      59.749 134.619 -65.890  1.00 56.45           C  
ATOM    599  CG  ARG A 203      60.299 135.072 -67.220  1.00 55.21           C  
ATOM    600  CD  ARG A 203      61.174 134.023 -67.835  1.00 56.43           C  
ATOM    601  NE  ARG A 203      61.600 134.423 -69.167  1.00 57.49           N  
ATOM    602  CZ  ARG A 203      62.423 133.716 -69.930  1.00 57.58           C  
ATOM    603  NH1 ARG A 203      62.913 132.565 -69.492  1.00 58.70           N  
ATOM    604  NH2 ARG A 203      62.746 134.157 -71.134  1.00 57.62           N  
ATOM    605  N   SER A 204      59.477 137.889 -65.932  1.00 57.28           N  
ATOM    606  CA  SER A 204      60.220 139.137 -65.863  1.00 57.07           C  
ATOM    607  C   SER A 204      59.356 140.356 -66.120  1.00 56.73           C  
ATOM    608  O   SER A 204      58.383 140.300 -66.859  1.00 57.08           O  
ATOM    609  CB  SER A 204      61.342 139.119 -66.885  1.00 58.05           C  
ATOM    610  OG  SER A 204      60.808 139.252 -68.185  1.00 56.65           O  
ATOM    611  N   VAL A 205      59.786 141.476 -65.556  1.00 56.81           N  
ATOM    612  CA  VAL A 205      59.097 142.747 -65.672  1.00 55.52           C  
ATOM    613  C   VAL A 205      59.101 143.267 -67.092  1.00 56.00           C  
ATOM    614  O   VAL A 205      58.093 143.765 -67.591  1.00 56.86           O  
ATOM    615  CB  VAL A 205      59.776 143.792 -64.792  1.00 53.89           C  
ATOM    616  CG1 VAL A 205      59.032 145.095 -64.852  1.00 55.49           C  
ATOM    617  CG2 VAL A 205      59.848 143.297 -63.377  1.00 56.31           C  
ATOM    618  N   ASP A 206      60.242 143.153 -67.750  1.00 56.10           N  
ATOM    619  CA  ASP A 206      60.346 143.669 -69.100  1.00 56.13           C  
ATOM    620  C   ASP A 206      59.523 142.901 -70.101  1.00 53.45           C  
ATOM    621  O   ASP A 206      58.968 143.487 -71.017  1.00 53.95           O  
ATOM    622  CB  ASP A 206      61.799 143.723 -69.537  1.00 59.99           C  
ATOM    623  CG  ASP A 206      61.947 144.146 -70.973  1.00 63.34           C  
ATOM    624  OD1 ASP A 206      62.402 143.305 -71.786  1.00 65.81           O  
ATOM    625  OD2 ASP A 206      61.597 145.308 -71.285  1.00 64.90           O  
ATOM    626  N   GLU A 207      59.466 141.584 -69.938  1.00 52.74           N  
ATOM    627  CA  GLU A 207      58.697 140.739 -70.839  1.00 50.12           C  
ATOM    628  C   GLU A 207      57.203 140.991 -70.646  1.00 50.38           C  
ATOM    629  O   GLU A 207      56.423 140.921 -71.597  1.00 50.40           O  
ATOM    630  CB  GLU A 207      59.086 139.270 -70.653  1.00 48.64           C  
ATOM    631  CG  GLU A 207      60.518 139.004 -71.120  1.00 46.96           C  
ATOM    632  CD  GLU A 207      60.977 137.562 -70.950  1.00 48.79           C  
ATOM    633  OE1 GLU A 207      60.787 136.989 -69.856  1.00 47.96           O  
ATOM    634  OE2 GLU A 207      61.574 137.014 -71.904  1.00 47.21           O  
ATOM    635  N   THR A 208      56.827 141.344 -69.420  1.00 51.10           N  
ATOM    636  CA  THR A 208      55.449 141.677 -69.082  1.00 51.62           C  
ATOM    637  C   THR A 208      55.081 142.887 -69.938  1.00 53.17           C  
ATOM    638  O   THR A 208      54.015 142.944 -70.552  1.00 54.54           O  
ATOM    639  CB  THR A 208      55.343 142.102 -67.617  1.00 51.66           C  
ATOM    640  OG1 THR A 208      55.807 141.044 -66.766  1.00 48.39           O  
ATOM    641  CG2 THR A 208      53.906 142.458 -67.269  1.00 54.55           C  
ATOM    642  N   THR A 209      56.012 143.831 -70.017  1.00 54.42           N  
ATOM    643  CA  THR A 209      55.823 145.050 -70.792  1.00 54.66           C  
ATOM    644  C   THR A 209      55.786 144.766 -72.284  1.00 56.50           C  
ATOM    645  O   THR A 209      54.911 145.257 -73.000  1.00 58.67           O  
ATOM    646  CB  THR A 209      56.949 146.045 -70.523  1.00 51.36           C  
ATOM    647  OG1 THR A 209      56.992 146.332 -69.126  1.00 54.92           O  
ATOM    648  CG2 THR A 209      56.723 147.320 -71.275  1.00 47.69           C  
ATOM    649  N   GLN A 210      56.722 143.949 -72.743  1.00 56.15           N  
ATOM    650  CA  GLN A 210      56.818 143.626 -74.151  1.00 55.84           C  
ATOM    651  C   GLN A 210      55.554 143.023 -74.726  1.00 55.67           C  
ATOM    652  O   GLN A 210      55.152 143.370 -75.833  1.00 56.10           O  
ATOM    653  CB  GLN A 210      57.980 142.677 -74.381  1.00 58.53           C  
ATOM    654  CG  GLN A 210      58.863 143.075 -75.534  1.00 59.17           C  
ATOM    655  CD  GLN A 210      59.565 144.369 -75.279  1.00 60.13           C  
ATOM    656  OE1 GLN A 210      59.810 145.140 -76.201  1.00 62.74           O  
ATOM    657  NE2 GLN A 210      59.901 144.625 -74.016  1.00 61.19           N  
ATOM    658  N   ALA A 211      54.917 142.143 -73.960  1.00 55.27           N  
ATOM    659  CA  ALA A 211      53.701 141.470 -74.407  1.00 54.47           C  
ATOM    660  C   ALA A 211      52.530 142.404 -74.680  1.00 55.78           C  
ATOM    661  O   ALA A 211      51.623 142.065 -75.443  1.00 57.91           O  
ATOM    662  CB  ALA A 211      53.300 140.392 -73.416  1.00 53.83           C  
ATOM    663  N   MET A 212      52.564 143.596 -74.099  1.00 55.12           N  
ATOM    664  CA  MET A 212      51.487 144.551 -74.298  1.00 54.03           C  
ATOM    665  C   MET A 212      51.298 144.988 -75.748  1.00 54.51           C  
ATOM    666  O   MET A 212      50.259 145.530 -76.105  1.00 54.57           O  
ATOM    667  CB  MET A 212      51.686 145.752 -73.388  1.00 54.64           C  
ATOM    668  CG  MET A 212      51.493 145.407 -71.937  1.00 57.16           C  
ATOM    669  SD  MET A 212      51.517 146.849 -70.918  1.00 63.66           S  
ATOM    670  CE  MET A 212      49.938 147.576 -71.302  1.00 60.27           C  
ATOM    671  N   ALA A 213      52.297 144.743 -76.590  1.00 54.88           N  
ATOM    672  CA  ALA A 213      52.201 145.101 -78.000  1.00 53.53           C  
ATOM    673  C   ALA A 213      51.197 144.170 -78.685  1.00 54.46           C  
ATOM    674  O   ALA A 213      50.850 144.356 -79.860  1.00 55.72           O  
ATOM    675  CB  ALA A 213      53.556 144.984 -78.656  1.00 52.86           C  
ATOM    676  N   PHE A 214      50.758 143.152 -77.950  1.00 52.82           N  
ATOM    677  CA  PHE A 214      49.798 142.191 -78.464  1.00 52.88           C  
ATOM    678  C   PHE A 214      48.358 142.603 -78.188  1.00 53.79           C  
ATOM    679  O   PHE A 214      47.441 141.794 -78.307  1.00 55.52           O  
ATOM    680  CB  PHE A 214      50.085 140.802 -77.885  1.00 50.62           C  
ATOM    681  CG  PHE A 214      51.301 140.147 -78.482  1.00 51.25           C  
ATOM    682  CD1 PHE A 214      51.594 140.298 -79.843  1.00 51.66           C  
ATOM    683  CD2 PHE A 214      52.173 139.411 -77.694  1.00 48.10           C  
ATOM    684  CE1 PHE A 214      52.746 139.733 -80.396  1.00 49.17           C  
ATOM    685  CE2 PHE A 214      53.318 138.850 -78.243  1.00 45.95           C  
ATOM    686  CZ  PHE A 214      53.604 139.008 -79.593  1.00 48.47           C  
ATOM    687  N   ASP A 215      48.156 143.860 -77.813  1.00 54.33           N  
ATOM    688  CA  ASP A 215      46.818 144.353 -77.517  1.00 54.76           C  
ATOM    689  C   ASP A 215      45.988 144.366 -78.784  1.00 54.12           C  
ATOM    690  O   ASP A 215      46.419 144.892 -79.798  1.00 55.63           O  
ATOM    691  CB  ASP A 215      46.888 145.765 -76.934  1.00 56.16           C  
ATOM    692  CG  ASP A 215      45.576 146.212 -76.316  1.00 56.90           C  
ATOM    693  OD1 ASP A 215      44.869 145.362 -75.739  1.00 57.98           O  
ATOM    694  OD2 ASP A 215      45.256 147.416 -76.397  1.00 56.98           O  
ATOM    695  N   GLY A 216      44.821 143.735 -78.727  1.00 53.39           N  
ATOM    696  CA  GLY A 216      43.933 143.694 -79.873  1.00 53.12           C  
ATOM    697  C   GLY A 216      44.120 142.518 -80.808  1.00 52.99           C  
ATOM    698  O   GLY A 216      43.328 142.333 -81.723  1.00 54.34           O  
ATOM    699  N   ILE A 217      45.168 141.734 -80.586  1.00 53.00           N  
ATOM    700  CA  ILE A 217      45.471 140.566 -81.402  1.00 52.05           C  
ATOM    701  C   ILE A 217      44.275 139.639 -81.543  1.00 52.73           C  
ATOM    702  O   ILE A 217      43.507 139.443 -80.603  1.00 53.34           O  
ATOM    703  CB  ILE A 217      46.662 139.781 -80.810  1.00 51.41           C  
ATOM    704  CG1 ILE A 217      47.134 138.715 -81.786  1.00 51.73           C  
ATOM    705  CG2 ILE A 217      46.272 139.130 -79.512  1.00 53.00           C  
ATOM    706  CD1 ILE A 217      48.500 138.194 -81.474  1.00 52.37           C  
ATOM    707  N   ILE A 218      44.101 139.087 -82.734  1.00 54.58           N  
ATOM    708  CA  ILE A 218      42.988 138.187 -82.957  1.00 56.10           C  
ATOM    709  C   ILE A 218      43.341 136.792 -82.523  1.00 56.16           C  
ATOM    710  O   ILE A 218      44.341 136.234 -82.952  1.00 57.72           O  
ATOM    711  CB  ILE A 218      42.531 138.161 -84.428  1.00 58.18           C  
ATOM    712  CG1 ILE A 218      41.212 137.400 -84.529  1.00 57.59           C  
ATOM    713  CG2 ILE A 218      43.596 137.535 -85.325  1.00 58.84           C  
ATOM    714  CD1 ILE A 218      40.135 138.000 -83.678  1.00 57.87           C  
ATOM    715  N   PHE A 219      42.513 136.236 -81.655  1.00 56.86           N  
ATOM    716  CA  PHE A 219      42.726 134.891 -81.157  1.00 56.99           C  
ATOM    717  C   PHE A 219      41.371 134.219 -81.082  1.00 56.39           C  
ATOM    718  O   PHE A 219      40.517 134.632 -80.304  1.00 57.26           O  
ATOM    719  CB  PHE A 219      43.362 134.943 -79.771  1.00 58.58           C  
ATOM    720  CG  PHE A 219      43.544 133.597 -79.134  1.00 59.27           C  
ATOM    721  CD1 PHE A 219      44.225 132.584 -79.803  1.00 59.69           C  
ATOM    722  CD2 PHE A 219      43.065 133.355 -77.859  1.00 58.82           C  
ATOM    723  CE1 PHE A 219      44.434 131.350 -79.207  1.00 59.62           C  
ATOM    724  CE2 PHE A 219      43.268 132.125 -77.251  1.00 61.46           C  
ATOM    725  CZ  PHE A 219      43.957 131.117 -77.928  1.00 61.18           C  
ATOM    726  N   GLN A 220      41.176 133.195 -81.903  1.00 55.49           N  
ATOM    727  CA  GLN A 220      39.913 132.467 -81.944  1.00 56.67           C  
ATOM    728  C   GLN A 220      38.725 133.417 -82.110  1.00 56.40           C  
ATOM    729  O   GLN A 220      37.800 133.413 -81.300  1.00 56.88           O  
ATOM    730  CB  GLN A 220      39.726 131.609 -80.688  1.00 56.06           C  
ATOM    731  CG  GLN A 220      40.837 130.602 -80.405  1.00 59.09           C  
ATOM    732  CD  GLN A 220      41.177 129.704 -81.588  1.00 60.70           C  
ATOM    733  OE1 GLN A 220      40.304 129.263 -82.338  1.00 61.70           O  
ATOM    734  NE2 GLN A 220      42.464 129.428 -81.755  1.00 63.35           N  
ATOM    735  N   GLY A 221      38.785 134.258 -83.141  1.00 56.75           N  
ATOM    736  CA  GLY A 221      37.710 135.200 -83.410  1.00 56.59           C  
ATOM    737  C   GLY A 221      37.535 136.390 -82.473  1.00 55.95           C  
ATOM    738  O   GLY A 221      36.819 137.326 -82.818  1.00 55.57           O  
ATOM    739  N   GLN A 222      38.160 136.361 -81.298  1.00 55.62           N  
ATOM    740  CA  GLN A 222      38.045 137.461 -80.346  1.00 55.81           C  
ATOM    741  C   GLN A 222      39.292 138.337 -80.331  1.00 55.01           C  
ATOM    742  O   GLN A 222      40.411 137.837 -80.359  1.00 55.60           O  
ATOM    743  CB  GLN A 222      37.780 136.933 -78.938  1.00 57.14           C  
ATOM    744  CG  GLN A 222      36.553 136.058 -78.818  1.00 61.25           C  
ATOM    745  CD  GLN A 222      35.290 136.753 -79.283  1.00 65.51           C  
ATOM    746  OE1 GLN A 222      34.641 137.467 -78.514  1.00 67.35           O  
ATOM    747  NE2 GLN A 222      34.930 136.546 -80.552  1.00 67.28           N  
ATOM    748  N   SER A 223      39.078 139.649 -80.310  1.00 55.04           N  
ATOM    749  CA  SER A 223      40.147 140.640 -80.281  1.00 53.24           C  
ATOM    750  C   SER A 223      40.472 140.890 -78.814  1.00 52.36           C  
ATOM    751  O   SER A 223      39.671 141.464 -78.088  1.00 52.19           O  
ATOM    752  CB  SER A 223      39.662 141.920 -80.957  1.00 53.37           C  
ATOM    753  OG  SER A 223      40.657 142.919 -80.939  1.00 54.66           O  
ATOM    754  N   LEU A 224      41.651 140.455 -78.386  1.00 52.86           N  
ATOM    755  CA  LEU A 224      42.071 140.569 -76.991  1.00 51.59           C  
ATOM    756  C   LEU A 224      42.392 141.961 -76.441  1.00 52.70           C  
ATOM    757  O   LEU A 224      43.090 142.759 -77.059  1.00 52.74           O  
ATOM    758  CB  LEU A 224      43.246 139.637 -76.746  1.00 50.37           C  
ATOM    759  CG  LEU A 224      43.008 138.181 -77.130  1.00 52.11           C  
ATOM    760  CD1 LEU A 224      44.282 137.392 -76.864  1.00 54.13           C  
ATOM    761  CD2 LEU A 224      41.837 137.597 -76.348  1.00 51.14           C  
ATOM    762  N   LYS A 225      41.886 142.238 -75.248  1.00 54.01           N  
ATOM    763  CA  LYS A 225      42.127 143.518 -74.615  1.00 53.68           C  
ATOM    764  C   LYS A 225      43.146 143.308 -73.529  1.00 53.72           C  
ATOM    765  O   LYS A 225      42.807 142.834 -72.445  1.00 55.94           O  
ATOM    766  CB  LYS A 225      40.837 144.069 -74.017  1.00 54.30           C  
ATOM    767  CG  LYS A 225      40.935 145.503 -73.514  1.00 55.66           C  
ATOM    768  CD  LYS A 225      39.580 146.160 -73.634  1.00 57.97           C  
ATOM    769  CE  LYS A 225      39.353 147.210 -72.589  1.00 60.10           C  
ATOM    770  NZ  LYS A 225      37.912 147.598 -72.619  1.00 64.72           N  
ATOM    771  N   ILE A 226      44.395 143.654 -73.834  1.00 52.20           N  
ATOM    772  CA  ILE A 226      45.505 143.508 -72.905  1.00 51.12           C  
ATOM    773  C   ILE A 226      45.704 144.812 -72.160  1.00 51.64           C  
ATOM    774  O   ILE A 226      45.779 145.855 -72.773  1.00 54.68           O  
ATOM    775  CB  ILE A 226      46.795 143.104 -73.652  1.00 49.40           C  
ATOM    776  CG1 ILE A 226      46.559 141.796 -74.408  1.00 43.74           C  
ATOM    777  CG2 ILE A 226      47.948 142.945 -72.675  1.00 50.06           C  
ATOM    778  CD1 ILE A 226      47.739 141.304 -75.137  1.00 42.28           C  
ATOM    779  N   ARG A 227      45.748 144.740 -70.833  1.00 52.95           N  
ATOM    780  CA  ARG A 227      45.913 145.909 -69.967  1.00 52.23           C  
ATOM    781  C   ARG A 227      46.750 145.533 -68.750  1.00 52.48           C  
ATOM    782  O   ARG A 227      46.856 144.368 -68.393  1.00 53.27           O  
ATOM    783  CB  ARG A 227      44.554 146.374 -69.444  1.00 52.89           C  
ATOM    784  CG  ARG A 227      43.591 146.912 -70.467  1.00 54.03           C  
ATOM    785  CD  ARG A 227      44.103 148.177 -71.099  1.00 54.59           C  
ATOM    786  NE  ARG A 227      44.072 148.052 -72.549  1.00 57.20           N  
ATOM    787  CZ  ARG A 227      43.087 148.496 -73.312  1.00 57.01           C  
ATOM    788  NH1 ARG A 227      42.057 149.114 -72.758  1.00 60.00           N  
ATOM    789  NH2 ARG A 227      43.100 148.258 -74.614  1.00 57.22           N  
ATOM    790  N   ARG A 228      47.309 146.525 -68.078  1.00 52.92           N  
ATOM    791  CA  ARG A 228      48.104 146.244 -66.893  1.00 54.28           C  
ATOM    792  C   ARG A 228      47.108 145.993 -65.789  1.00 54.89           C  
ATOM    793  O   ARG A 228      45.927 146.280 -65.956  1.00 56.69           O  
ATOM    794  CB  ARG A 228      48.986 147.443 -66.539  1.00 52.68           C  
ATOM    795  CG  ARG A 228      49.657 148.050 -67.743  1.00 51.55           C  
ATOM    796  CD  ARG A 228      51.040 148.546 -67.431  1.00 50.85           C  
ATOM    797  NE  ARG A 228      51.942 147.443 -67.139  1.00 50.57           N  
ATOM    798  CZ  ARG A 228      53.154 147.311 -67.664  1.00 49.75           C  
ATOM    799  NH1 ARG A 228      53.620 148.210 -68.514  1.00 49.94           N  
ATOM    800  NH2 ARG A 228      53.908 146.279 -67.324  1.00 51.43           N  
ATOM    801  N   PRO A 229      47.545 145.406 -64.663  1.00 56.50           N  
ATOM    802  CA  PRO A 229      46.562 145.178 -63.601  1.00 57.84           C  
ATOM    803  C   PRO A 229      46.119 146.528 -63.044  1.00 60.90           C  
ATOM    804  O   PRO A 229      46.732 147.561 -63.346  1.00 60.85           O  
ATOM    805  CB  PRO A 229      47.364 144.385 -62.568  1.00 55.61           C  
ATOM    806  CG  PRO A 229      48.389 143.670 -63.392  1.00 53.63           C  
ATOM    807  CD  PRO A 229      48.825 144.749 -64.342  1.00 55.01           C  
ATOM    808  N  AHIS A 230      45.042 146.550 -62.265  0.65 63.05           N  
ATOM    809  N  BHIS A 230      45.053 146.511 -62.247  0.35 61.98           N  
ATOM    810  CA AHIS A 230      44.604 147.819 -61.694  0.65 65.06           C  
ATOM    811  CA BHIS A 230      44.506 147.720 -61.633  0.35 62.57           C  
ATOM    812  C  AHIS A 230      45.465 148.235 -60.507  0.65 65.84           C  
ATOM    813  C  BHIS A 230      45.414 148.206 -60.505  0.35 64.16           C  
ATOM    814  O  AHIS A 230      45.720 149.427 -60.315  0.65 66.86           O  
ATOM    815  O  BHIS A 230      45.649 149.407 -60.357  0.35 64.58           O  
ATOM    816  CB AHIS A 230      43.112 147.811 -61.355  0.65 66.61           C  
ATOM    817  CB BHIS A 230      43.107 147.435 -61.075  0.35 60.60           C  
ATOM    818  CG AHIS A 230      42.241 148.184 -62.518  0.65 67.17           C  
ATOM    819  CG BHIS A 230      42.326 148.665 -60.724  0.35 57.99           C  
ATOM    820  ND1AHIS A 230      40.895 147.887 -62.568  0.65 67.43           N  
ATOM    821  ND1BHIS A 230      41.731 148.842 -59.495  0.35 57.64           N  
ATOM    822  CD2AHIS A 230      42.530 148.825 -63.672  0.65 65.91           C  
ATOM    823  CD2BHIS A 230      42.023 149.766 -61.451  0.35 57.91           C  
ATOM    824  CE1AHIS A 230      40.395 148.333 -63.707  0.65 67.58           C  
ATOM    825  CE1BHIS A 230      41.093 149.999 -59.480  0.35 56.78           C  
ATOM    826  NE2AHIS A 230      41.364 148.905 -64.396  0.65 65.36           N  
ATOM    827  NE2BHIS A 230      41.254 150.579 -60.654  0.35 56.83           N  
ATOM    828  N   ASP A 231      45.953 147.256 -59.744  1.00 65.89           N  
ATOM    829  CA  ASP A 231      46.825 147.550 -58.612  1.00 66.19           C  
ATOM    830  C   ASP A 231      48.196 148.034 -59.078  1.00 66.36           C  
ATOM    831  O   ASP A 231      48.981 148.557 -58.285  1.00 68.77           O  
ATOM    832  CB  ASP A 231      46.969 146.326 -57.684  1.00 69.00           C  
ATOM    833  CG  ASP A 231      47.535 145.089 -58.391  1.00 72.23           C  
ATOM    834  OD1 ASP A 231      47.399 143.973 -57.841  1.00 73.98           O  
ATOM    835  OD2 ASP A 231      48.115 145.211 -59.491  1.00 75.03           O  
ATOM    836  N   TYR A 232      48.457 147.899 -60.375  1.00 65.06           N  
ATOM    837  CA  TYR A 232      49.735 148.301 -60.946  1.00 65.30           C  
ATOM    838  C   TYR A 232      50.075 149.784 -60.912  1.00 66.12           C  
ATOM    839  O   TYR A 232      49.215 150.652 -61.005  1.00 66.97           O  
ATOM    840  CB  TYR A 232      49.872 147.800 -62.391  1.00 63.39           C  
ATOM    841  CG  TYR A 232      51.131 148.281 -63.092  1.00 58.79           C  
ATOM    842  CD1 TYR A 232      52.349 147.656 -62.874  1.00 58.74           C  
ATOM    843  CD2 TYR A 232      51.104 149.376 -63.942  1.00 57.75           C  
ATOM    844  CE1 TYR A 232      53.516 148.108 -63.480  1.00 59.15           C  
ATOM    845  CE2 TYR A 232      52.263 149.838 -64.557  1.00 59.67           C  
ATOM    846  CZ  TYR A 232      53.470 149.199 -64.319  1.00 59.07           C  
ATOM    847  OH  TYR A 232      54.631 149.650 -64.906  1.00 56.66           O  
ATOM    848  N   GLN A 233      51.374 150.030 -60.802  1.00 68.08           N  
ATOM    849  CA  GLN A 233      51.982 151.355 -60.799  1.00 68.92           C  
ATOM    850  C   GLN A 233      53.465 151.042 -60.987  1.00 67.48           C  
ATOM    851  O   GLN A 233      53.948 150.011 -60.499  1.00 66.81           O  
ATOM    852  CB  GLN A 233      51.751 152.093 -59.475  1.00 71.04           C  
ATOM    853  CG  GLN A 233      52.387 151.439 -58.268  1.00 75.25           C  
ATOM    854  CD  GLN A 233      52.720 152.441 -57.181  1.00 79.37           C  
ATOM    855  OE1 GLN A 233      52.500 153.648 -57.340  1.00 81.31           O  
ATOM    856  NE2 GLN A 233      53.278 151.949 -56.072  1.00 81.12           N  
ATOM    857  N   PRO A 234      54.185 151.882 -61.752  1.00 65.76           N  
ATOM    858  CA  PRO A 234      55.613 151.695 -62.013  1.00 65.11           C  
ATOM    859  C   PRO A 234      56.448 151.453 -60.764  1.00 63.58           C  
ATOM    860  O   PRO A 234      56.149 151.967 -59.684  1.00 63.92           O  
ATOM    861  CB  PRO A 234      55.997 152.994 -62.712  1.00 65.72           C  
ATOM    862  CG  PRO A 234      54.785 153.292 -63.508  1.00 64.86           C  
ATOM    863  CD  PRO A 234      53.681 153.050 -62.494  1.00 66.40           C  
ATOM    864  N   LEU A 235      57.476 150.626 -60.927  1.00 63.34           N  
ATOM    865  CA  LEU A 235      58.386 150.268 -59.848  1.00 61.49           C  
ATOM    866  C   LEU A 235      59.283 151.423 -59.434  1.00 61.62           C  
ATOM    867  O   LEU A 235      59.669 152.255 -60.254  1.00 60.18           O  
ATOM    868  CB  LEU A 235      59.247 149.088 -60.270  1.00 61.80           C  
ATOM    869  CG  LEU A 235      58.500 147.799 -60.577  1.00 62.17           C  
ATOM    870  CD1 LEU A 235      59.481 146.784 -61.159  1.00 63.35           C  
ATOM    871  CD2 LEU A 235      57.829 147.273 -59.314  1.00 60.72           C  
ATOM    872  N   PRO A 236      59.651 151.465 -58.148  1.00 62.65           N  
ATOM    873  CA  PRO A 236      60.502 152.482 -57.535  1.00 64.16           C  
ATOM    874  C   PRO A 236      61.593 153.189 -58.351  1.00 65.75           C  
ATOM    875  O   PRO A 236      61.766 154.393 -58.207  1.00 69.23           O  
ATOM    876  CB  PRO A 236      61.034 151.754 -56.320  1.00 62.90           C  
ATOM    877  CG  PRO A 236      59.780 151.069 -55.846  1.00 62.08           C  
ATOM    878  CD  PRO A 236      59.198 150.502 -57.126  1.00 61.53           C  
ATOM    879  N   GLY A 237      62.331 152.490 -59.200  1.00 65.49           N  
ATOM    880  CA  GLY A 237      63.356 153.197 -59.956  1.00 64.06           C  
ATOM    881  C   GLY A 237      62.954 153.448 -61.394  1.00 64.24           C  
ATOM    882  O   GLY A 237      63.775 153.863 -62.215  1.00 65.23           O  
ATOM    883  N   ALA A 258      61.680 153.212 -61.690  1.00 62.93           N  
ATOM    884  CA  ALA A 258      61.142 153.357 -63.036  1.00 60.73           C  
ATOM    885  C   ALA A 258      61.577 154.588 -63.813  1.00 60.78           C  
ATOM    886  O   ALA A 258      62.067 154.464 -64.932  1.00 61.33           O  
ATOM    887  CB  ALA A 258      59.645 153.266 -63.002  1.00 59.48           C  
ATOM    888  N   HIS A 259      61.417 155.772 -63.229  1.00 61.39           N  
ATOM    889  CA  HIS A 259      61.790 157.003 -63.925  1.00 61.92           C  
ATOM    890  C   HIS A 259      62.901 157.796 -63.238  1.00 61.63           C  
ATOM    891  O   HIS A 259      63.059 158.994 -63.474  1.00 62.29           O  
ATOM    892  CB  HIS A 259      60.553 157.877 -64.141  1.00 63.51           C  
ATOM    893  CG  HIS A 259      59.439 157.170 -64.847  1.00 65.02           C  
ATOM    894  ND1 HIS A 259      58.623 156.253 -64.218  1.00 65.57           N  
ATOM    895  CD2 HIS A 259      59.030 157.213 -66.138  1.00 65.79           C  
ATOM    896  CE1 HIS A 259      57.764 155.757 -65.091  1.00 65.03           C  
ATOM    897  NE2 HIS A 259      57.990 156.324 -66.263  1.00 66.48           N  
ATOM    898  N   LYS A 260      63.682 157.107 -62.411  1.00 61.02           N  
ATOM    899  CA  LYS A 260      64.796 157.704 -61.690  1.00 58.73           C  
ATOM    900  C   LYS A 260      65.727 158.444 -62.627  1.00 57.37           C  
ATOM    901  O   LYS A 260      66.043 157.957 -63.704  1.00 57.01           O  
ATOM    902  CB  LYS A 260      65.577 156.618 -60.952  1.00 60.14           C  
ATOM    903  CG  LYS A 260      66.902 157.080 -60.371  1.00 63.73           C  
ATOM    904  CD  LYS A 260      67.345 156.176 -59.249  1.00 65.72           C  
ATOM    905  CE  LYS A 260      66.912 154.761 -59.495  1.00 66.21           C  
ATOM    906  NZ  LYS A 260      67.983 153.818 -59.095  1.00 69.61           N  
ATOM    907  N   LEU A 261      66.132 159.643 -62.226  1.00 57.76           N  
ATOM    908  CA  LEU A 261      67.048 160.445 -63.030  1.00 57.94           C  
ATOM    909  C   LEU A 261      68.447 160.456 -62.441  1.00 57.75           C  
ATOM    910  O   LEU A 261      68.630 160.308 -61.226  1.00 58.00           O  
ATOM    911  CB  LEU A 261      66.554 161.887 -63.146  1.00 58.02           C  
ATOM    912  CG  LEU A 261      65.304 162.103 -63.993  1.00 60.04           C  
ATOM    913  CD1 LEU A 261      64.861 163.555 -63.942  1.00 60.60           C  
ATOM    914  CD2 LEU A 261      65.603 161.686 -65.413  1.00 61.23           C  
ATOM    915  N   PHE A 262      69.432 160.594 -63.320  1.00 56.94           N  
ATOM    916  CA  PHE A 262      70.824 160.685 -62.916  1.00 56.22           C  
ATOM    917  C   PHE A 262      71.165 162.148 -63.099  1.00 57.39           C  
ATOM    918  O   PHE A 262      70.810 162.744 -64.115  1.00 58.87           O  
ATOM    919  CB  PHE A 262      71.715 159.844 -63.826  1.00 56.55           C  
ATOM    920  CG  PHE A 262      73.185 160.144 -63.683  1.00 56.13           C  
ATOM    921  CD1 PHE A 262      73.938 159.533 -62.698  1.00 57.96           C  
ATOM    922  CD2 PHE A 262      73.815 161.034 -64.539  1.00 57.54           C  
ATOM    923  CE1 PHE A 262      75.294 159.801 -62.566  1.00 58.52           C  
ATOM    924  CE2 PHE A 262      75.168 161.309 -64.417  1.00 58.12           C  
ATOM    925  CZ  PHE A 262      75.909 160.691 -63.428  1.00 59.14           C  
ATOM    926  N   ILE A 263      71.788 162.745 -62.091  1.00 58.72           N  
ATOM    927  CA  ILE A 263      72.184 164.142 -62.166  1.00 58.43           C  
ATOM    928  C   ILE A 263      73.652 164.249 -61.792  1.00 60.11           C  
ATOM    929  O   ILE A 263      74.024 164.052 -60.633  1.00 59.77           O  
ATOM    930  CB  ILE A 263      71.387 165.036 -61.219  1.00 57.38           C  
ATOM    931  CG1 ILE A 263      69.885 164.864 -61.441  1.00 58.34           C  
ATOM    932  CG2 ILE A 263      71.781 166.482 -61.444  1.00 58.69           C  
ATOM    933  CD1 ILE A 263      69.261 163.731 -60.637  1.00 58.93           C  
ATOM    934  N   GLY A 264      74.487 164.514 -62.793  1.00 61.26           N  
ATOM    935  CA  GLY A 264      75.911 164.636 -62.560  1.00 62.53           C  
ATOM    936  C   GLY A 264      76.394 166.047 -62.815  1.00 63.81           C  
ATOM    937  O   GLY A 264      75.612 166.914 -63.216  1.00 64.58           O  
ATOM    938  N   GLY A 265      77.684 166.276 -62.578  1.00 64.59           N  
ATOM    939  CA  GLY A 265      78.262 167.591 -62.789  1.00 65.09           C  
ATOM    940  C   GLY A 265      77.999 168.544 -61.639  1.00 64.59           C  
ATOM    941  O   GLY A 265      78.221 169.751 -61.759  1.00 66.65           O  
ATOM    942  N   LEU A 266      77.511 168.005 -60.528  1.00 62.80           N  
ATOM    943  CA  LEU A 266      77.228 168.800 -59.342  1.00 61.53           C  
ATOM    944  C   LEU A 266      78.523 169.244 -58.669  1.00 63.67           C  
ATOM    945  O   LEU A 266      79.509 168.508 -58.670  1.00 63.88           O  
ATOM    946  CB  LEU A 266      76.425 167.973 -58.344  1.00 56.70           C  
ATOM    947  CG  LEU A 266      75.018 167.590 -58.758  1.00 53.65           C  
ATOM    948  CD1 LEU A 266      74.484 166.502 -57.856  1.00 52.70           C  
ATOM    949  CD2 LEU A 266      74.151 168.817 -58.712  1.00 53.33           C  
ATOM    950  N   PRO A 267      78.565 170.491 -58.166  1.00 66.85           N  
ATOM    951  CA  PRO A 267      79.773 170.977 -57.494  1.00 68.89           C  
ATOM    952  C   PRO A 267      79.906 170.175 -56.211  1.00 70.24           C  
ATOM    953  O   PRO A 267      78.910 169.884 -55.545  1.00 70.98           O  
ATOM    954  CB  PRO A 267      79.432 172.436 -57.201  1.00 68.28           C  
ATOM    955  CG  PRO A 267      78.520 172.805 -58.327  1.00 68.35           C  
ATOM    956  CD  PRO A 267      77.612 171.597 -58.375  1.00 68.39           C  
ATOM    957  N   ASN A 268      81.126 169.784 -55.880  1.00 71.75           N  
ATOM    958  CA  ASN A 268      81.346 168.984 -54.685  1.00 73.38           C  
ATOM    959  C   ASN A 268      80.849 169.617 -53.384  1.00 73.00           C  
ATOM    960  O   ASN A 268      80.541 168.902 -52.440  1.00 74.24           O  
ATOM    961  CB  ASN A 268      82.828 168.642 -54.556  1.00 75.50           C  
ATOM    962  CG  ASN A 268      83.687 169.872 -54.321  1.00 79.38           C  
ATOM    963  OD1 ASN A 268      83.662 170.460 -53.236  1.00 81.44           O  
ATOM    964  ND2 ASN A 268      84.432 170.285 -55.346  1.00 81.44           N  
ATOM    965  N   TYR A 269      80.744 170.944 -53.340  1.00 73.60           N  
ATOM    966  CA  TYR A 269      80.318 171.626 -52.118  1.00 73.67           C  
ATOM    967  C   TYR A 269      78.865 171.527 -51.669  1.00 74.57           C  
ATOM    968  O   TYR A 269      78.615 171.478 -50.463  1.00 74.66           O  
ATOM    969  CB  TYR A 269      80.796 173.088 -52.077  1.00 73.01           C  
ATOM    970  CG  TYR A 269      80.611 173.891 -53.344  1.00 71.33           C  
ATOM    971  CD1 TYR A 269      79.475 174.667 -53.541  1.00 70.86           C  
ATOM    972  CD2 TYR A 269      81.586 173.886 -54.343  1.00 72.01           C  
ATOM    973  CE1 TYR A 269      79.305 175.416 -54.701  1.00 71.05           C  
ATOM    974  CE2 TYR A 269      81.431 174.634 -55.509  1.00 72.35           C  
ATOM    975  CZ  TYR A 269      80.284 175.394 -55.682  1.00 72.42           C  
ATOM    976  OH  TYR A 269      80.102 176.109 -56.849  1.00 74.07           O  
ATOM    977  N   LEU A 270      77.919 171.478 -52.611  1.00 75.46           N  
ATOM    978  CA  LEU A 270      76.489 171.379 -52.277  1.00 75.89           C  
ATOM    979  C   LEU A 270      76.152 170.134 -51.456  1.00 77.02           C  
ATOM    980  O   LEU A 270      76.815 169.108 -51.575  1.00 77.41           O  
ATOM    981  CB  LEU A 270      75.636 171.371 -53.543  1.00 75.16           C  
ATOM    982  CG  LEU A 270      75.560 172.626 -54.411  1.00 76.07           C  
ATOM    983  CD1 LEU A 270      76.908 172.955 -55.006  1.00 76.03           C  
ATOM    984  CD2 LEU A 270      74.557 172.397 -55.519  1.00 76.11           C  
ATOM    985  N   ASN A 271      75.134 170.233 -50.605  1.00 79.06           N  
ATOM    986  CA  ASN A 271      74.715 169.099 -49.781  1.00 81.44           C  
ATOM    987  C   ASN A 271      73.286 168.688 -50.146  1.00 82.13           C  
ATOM    988  O   ASN A 271      72.598 169.410 -50.869  1.00 81.75           O  
ATOM    989  CB  ASN A 271      74.828 169.430 -48.280  1.00 83.17           C  
ATOM    990  CG  ASN A 271      73.606 170.173 -47.734  1.00 84.92           C  
ATOM    991  OD1 ASN A 271      73.584 171.406 -47.670  1.00 84.58           O  
ATOM    992  ND2 ASN A 271      72.593 169.414 -47.313  1.00 84.00           N  
ATOM    993  N   ASP A 272      72.844 167.546 -49.622  1.00 82.72           N  
ATOM    994  CA  ASP A 272      71.509 167.017 -49.894  1.00 84.21           C  
ATOM    995  C   ASP A 272      70.412 168.059 -50.085  1.00 84.56           C  
ATOM    996  O   ASP A 272      69.860 168.180 -51.176  1.00 85.02           O  
ATOM    997  CB  ASP A 272      71.088 166.027 -48.800  1.00 86.28           C  
ATOM    998  CG  ASP A 272      71.827 164.691 -48.887  1.00 87.37           C  
ATOM    999  OD1 ASP A 272      71.705 163.873 -47.947  1.00 87.53           O  
ATOM   1000  OD2 ASP A 272      72.519 164.447 -49.897  1.00 87.95           O  
ATOM   1001  N   ASP A 273      70.145 168.843 -49.041  1.00 85.06           N  
ATOM   1002  CA  ASP A 273      69.102 169.875 -49.057  1.00 84.16           C  
ATOM   1003  C   ASP A 273      69.272 170.886 -50.181  1.00 83.80           C  
ATOM   1004  O   ASP A 273      68.294 171.330 -50.782  1.00 83.64           O  
ATOM   1005  CB  ASP A 273      69.064 170.608 -47.715  1.00 84.91           C  
ATOM   1006  CG  ASP A 273      69.086 169.658 -46.530  1.00 86.18           C  
ATOM   1007  OD1 ASP A 273      68.027 169.078 -46.199  1.00 86.43           O  
ATOM   1008  OD2 ASP A 273      70.173 169.483 -45.937  1.00 87.09           O  
ATOM   1009  N   GLN A 274      70.518 171.253 -50.453  1.00 84.35           N  
ATOM   1010  CA  GLN A 274      70.826 172.211 -51.509  1.00 84.61           C  
ATOM   1011  C   GLN A 274      70.533 171.598 -52.877  1.00 84.52           C  
ATOM   1012  O   GLN A 274      69.848 172.203 -53.707  1.00 84.25           O  
ATOM   1013  CB  GLN A 274      72.298 172.621 -51.432  1.00 85.20           C  
ATOM   1014  CG  GLN A 274      72.759 173.013 -50.039  1.00 86.10           C  
ATOM   1015  CD  GLN A 274      74.173 173.572 -50.022  1.00 87.05           C  
ATOM   1016  OE1 GLN A 274      74.449 174.607 -50.631  1.00 86.91           O  
ATOM   1017  NE2 GLN A 274      75.072 172.896 -49.314  1.00 86.94           N  
ATOM   1018  N   VAL A 275      71.054 170.389 -53.091  1.00 84.48           N  
ATOM   1019  CA  VAL A 275      70.866 169.656 -54.340  1.00 84.21           C  
ATOM   1020  C   VAL A 275      69.382 169.412 -54.572  1.00 84.14           C  
ATOM   1021  O   VAL A 275      68.868 169.684 -55.657  1.00 84.21           O  
ATOM   1022  CB  VAL A 275      71.596 168.294 -54.317  1.00 84.35           C  
ATOM   1023  CG1 VAL A 275      71.380 167.565 -55.624  1.00 83.19           C  
ATOM   1024  CG2 VAL A 275      73.084 168.491 -54.064  1.00 84.62           C  
ATOM   1025  N   LYS A 276      68.698 168.926 -53.539  1.00 84.04           N  
ATOM   1026  CA  LYS A 276      67.269 168.663 -53.623  1.00 84.26           C  
ATOM   1027  C   LYS A 276      66.496 169.898 -54.041  1.00 85.00           C  
ATOM   1028  O   LYS A 276      65.611 169.809 -54.883  1.00 85.46           O  
ATOM   1029  CB  LYS A 276      66.721 168.164 -52.289  1.00 84.30           C  
ATOM   1030  CG  LYS A 276      66.839 166.673 -52.082  1.00 84.80           C  
ATOM   1031  CD  LYS A 276      65.762 166.167 -51.126  1.00 85.91           C  
ATOM   1032  CE  LYS A 276      66.129 166.389 -49.674  1.00 85.94           C  
ATOM   1033  NZ  LYS A 276      67.240 165.486 -49.274  1.00 88.63           N  
ATOM   1034  N   GLU A 277      66.850 171.050 -53.471  1.00 86.18           N  
ATOM   1035  CA  GLU A 277      66.172 172.309 -53.782  1.00 86.97           C  
ATOM   1036  C   GLU A 277      66.198 172.628 -55.274  1.00 86.62           C  
ATOM   1037  O   GLU A 277      65.208 173.097 -55.840  1.00 87.01           O  
ATOM   1038  CB  GLU A 277      66.790 173.466 -53.001  1.00 88.50           C  
ATOM   1039  CG  GLU A 277      66.010 174.773 -53.145  1.00 91.63           C  
ATOM   1040  CD  GLU A 277      66.671 175.950 -52.443  1.00 93.18           C  
ATOM   1041  OE1 GLU A 277      67.071 175.801 -51.263  1.00 93.26           O  
ATOM   1042  OE2 GLU A 277      66.783 177.026 -53.077  1.00 93.65           O  
ATOM   1043  N   LEU A 278      67.324 172.340 -55.914  1.00 85.33           N  
ATOM   1044  CA  LEU A 278      67.469 172.595 -57.338  1.00 84.90           C  
ATOM   1045  C   LEU A 278      66.536 171.703 -58.174  1.00 84.18           C  
ATOM   1046  O   LEU A 278      66.091 172.091 -59.254  1.00 84.02           O  
ATOM   1047  CB  LEU A 278      68.937 172.409 -57.738  1.00 84.79           C  
ATOM   1048  CG  LEU A 278      69.458 172.991 -59.057  1.00 84.95           C  
ATOM   1049  CD1 LEU A 278      69.256 172.014 -60.187  1.00 86.30           C  
ATOM   1050  CD2 LEU A 278      68.792 174.323 -59.357  1.00 86.15           C  
ATOM   1051  N   LEU A 279      66.212 170.525 -57.652  1.00 83.76           N  
ATOM   1052  CA  LEU A 279      65.338 169.593 -58.355  1.00 83.27           C  
ATOM   1053  C   LEU A 279      63.876 169.864 -58.020  1.00 83.71           C  
ATOM   1054  O   LEU A 279      63.049 170.027 -58.923  1.00 84.63           O  
ATOM   1055  CB  LEU A 279      65.686 168.148 -57.985  1.00 82.03           C  
ATOM   1056  CG  LEU A 279      67.147 167.716 -58.115  1.00 80.89           C  
ATOM   1057  CD1 LEU A 279      67.314 166.336 -57.535  1.00 81.51           C  
ATOM   1058  CD2 LEU A 279      67.592 167.741 -59.558  1.00 81.18           C  
ATOM   1059  N   THR A 280      63.580 169.928 -56.718  1.00 83.28           N  
ATOM   1060  CA  THR A 280      62.232 170.168 -56.183  1.00 82.66           C  
ATOM   1061  C   THR A 280      61.448 171.216 -56.968  1.00 81.95           C  
ATOM   1062  O   THR A 280      60.224 171.149 -57.065  1.00 81.39           O  
ATOM   1063  CB  THR A 280      62.292 170.643 -54.712  1.00 82.73           C  
ATOM   1064  OG1 THR A 280      63.178 169.801 -53.969  1.00 84.02           O  
ATOM   1065  CG2 THR A 280      60.905 170.593 -54.073  1.00 82.10           C  
ATOM   1066  N   SER A 281      62.170 172.189 -57.510  1.00 81.60           N  
ATOM   1067  CA  SER A 281      61.576 173.263 -58.283  1.00 82.00           C  
ATOM   1068  C   SER A 281      60.561 172.755 -59.306  1.00 81.93           C  
ATOM   1069  O   SER A 281      59.444 173.279 -59.391  1.00 82.13           O  
ATOM   1070  CB  SER A 281      62.675 174.073 -58.978  1.00 82.96           C  
ATOM   1071  OG  SER A 281      63.392 173.288 -59.915  1.00 83.84           O  
ATOM   1072  N   PHE A 282      60.936 171.717 -60.052  1.00 81.44           N  
ATOM   1073  CA  PHE A 282      60.061 171.134 -61.071  1.00 80.14           C  
ATOM   1074  C   PHE A 282      58.934 170.268 -60.520  1.00 79.37           C  
ATOM   1075  O   PHE A 282      58.114 169.759 -61.283  1.00 80.08           O  
ATOM   1076  CB  PHE A 282      60.874 170.314 -62.059  1.00 80.43           C  
ATOM   1077  CG  PHE A 282      61.752 171.133 -62.938  1.00 81.33           C  
ATOM   1078  CD1 PHE A 282      62.920 171.692 -62.444  1.00 82.15           C  
ATOM   1079  CD2 PHE A 282      61.419 171.336 -64.270  1.00 81.59           C  
ATOM   1080  CE1 PHE A 282      63.746 172.442 -63.266  1.00 83.25           C  
ATOM   1081  CE2 PHE A 282      62.237 172.084 -65.101  1.00 82.11           C  
ATOM   1082  CZ  PHE A 282      63.403 172.639 -64.601  1.00 82.89           C  
ATOM   1083  N   GLY A 283      58.909 170.086 -59.204  1.00 77.91           N  
ATOM   1084  CA  GLY A 283      57.875 169.287 -58.577  1.00 76.21           C  
ATOM   1085  C   GLY A 283      58.446 168.460 -57.444  1.00 76.11           C  
ATOM   1086  O   GLY A 283      59.667 168.358 -57.307  1.00 76.66           O  
ATOM   1087  N   PRO A 284      57.588 167.895 -56.583  1.00 75.16           N  
ATOM   1088  CA  PRO A 284      58.004 167.066 -55.446  1.00 74.73           C  
ATOM   1089  C   PRO A 284      58.636 165.739 -55.876  1.00 73.20           C  
ATOM   1090  O   PRO A 284      58.194 165.112 -56.843  1.00 73.39           O  
ATOM   1091  CB  PRO A 284      56.688 166.827 -54.697  1.00 74.97           C  
ATOM   1092  CG  PRO A 284      55.895 168.041 -55.011  1.00 75.93           C  
ATOM   1093  CD  PRO A 284      56.153 168.206 -56.495  1.00 75.77           C  
ATOM   1094  N   LEU A 285      59.656 165.322 -55.128  1.00 71.19           N  
ATOM   1095  CA  LEU A 285      60.388 164.082 -55.370  1.00 69.32           C  
ATOM   1096  C   LEU A 285      59.840 162.934 -54.531  1.00 68.77           C  
ATOM   1097  O   LEU A 285      59.425 163.133 -53.389  1.00 67.86           O  
ATOM   1098  CB  LEU A 285      61.856 164.252 -54.977  1.00 68.81           C  
ATOM   1099  CG  LEU A 285      62.722 165.348 -55.573  1.00 66.75           C  
ATOM   1100  CD1 LEU A 285      63.986 165.485 -54.746  1.00 65.28           C  
ATOM   1101  CD2 LEU A 285      63.038 165.005 -57.011  1.00 69.61           C  
ATOM   1102  N   LYS A 286      59.896 161.724 -55.082  1.00 68.69           N  
ATOM   1103  CA  LYS A 286      59.445 160.540 -54.364  1.00 68.37           C  
ATOM   1104  C   LYS A 286      60.668 159.787 -53.810  1.00 67.56           C  
ATOM   1105  O   LYS A 286      60.542 158.986 -52.880  1.00 68.03           O  
ATOM   1106  CB  LYS A 286      58.597 159.632 -55.264  1.00 69.63           C  
ATOM   1107  CG  LYS A 286      59.373 158.824 -56.291  1.00 73.16           C  
ATOM   1108  CD  LYS A 286      58.585 157.598 -56.761  1.00 74.52           C  
ATOM   1109  CE  LYS A 286      57.607 157.923 -57.880  1.00 76.19           C  
ATOM   1110  NZ  LYS A 286      56.866 156.704 -58.340  1.00 76.17           N  
ATOM   1111  N   ALA A 287      61.847 160.076 -54.372  1.00 65.85           N  
ATOM   1112  CA  ALA A 287      63.115 159.465 -53.959  1.00 62.98           C  
ATOM   1113  C   ALA A 287      64.305 160.331 -54.371  1.00 62.85           C  
ATOM   1114  O   ALA A 287      64.267 160.994 -55.407  1.00 62.58           O  
ATOM   1115  CB  ALA A 287      63.256 158.091 -54.560  1.00 63.01           C  
ATOM   1116  N   PHE A 288      65.370 160.296 -53.571  1.00 62.66           N  
ATOM   1117  CA  PHE A 288      66.582 161.069 -53.839  1.00 62.04           C  
ATOM   1118  C   PHE A 288      67.775 160.581 -53.012  1.00 63.01           C  
ATOM   1119  O   PHE A 288      67.626 160.203 -51.848  1.00 62.01           O  
ATOM   1120  CB  PHE A 288      66.336 162.559 -53.554  1.00 62.68           C  
ATOM   1121  CG  PHE A 288      67.579 163.402 -53.607  1.00 62.26           C  
ATOM   1122  CD1 PHE A 288      67.951 164.038 -54.782  1.00 62.88           C  
ATOM   1123  CD2 PHE A 288      68.402 163.527 -52.489  1.00 63.34           C  
ATOM   1124  CE1 PHE A 288      69.129 164.779 -54.854  1.00 63.32           C  
ATOM   1125  CE2 PHE A 288      69.583 164.263 -52.546  1.00 64.57           C  
ATOM   1126  CZ  PHE A 288      69.948 164.892 -53.733  1.00 64.97           C  
ATOM   1127  N   ASN A 289      68.961 160.620 -53.619  1.00 64.11           N  
ATOM   1128  CA  ASN A 289      70.198 160.222 -52.953  1.00 64.83           C  
ATOM   1129  C   ASN A 289      71.422 160.862 -53.611  1.00 66.06           C  
ATOM   1130  O   ASN A 289      71.591 160.783 -54.824  1.00 67.91           O  
ATOM   1131  CB  ASN A 289      70.346 158.691 -52.919  1.00 65.22           C  
ATOM   1132  CG  ASN A 289      70.588 158.081 -54.293  1.00 64.55           C  
ATOM   1133  OD1 ASN A 289      69.689 158.019 -55.121  1.00 67.92           O  
ATOM   1134  ND2 ASN A 289      71.804 157.611 -54.527  1.00 63.15           N  
ATOM   1135  N   LEU A 290      72.231 161.557 -52.817  1.00 66.57           N  
ATOM   1136  CA  LEU A 290      73.450 162.186 -53.319  1.00 68.29           C  
ATOM   1137  C   LEU A 290      74.587 161.318 -52.835  1.00 70.46           C  
ATOM   1138  O   LEU A 290      74.769 161.162 -51.629  1.00 71.38           O  
ATOM   1139  CB  LEU A 290      73.620 163.591 -52.748  1.00 67.90           C  
ATOM   1140  CG  LEU A 290      74.964 164.264 -53.030  1.00 66.91           C  
ATOM   1141  CD1 LEU A 290      74.994 164.768 -54.458  1.00 68.07           C  
ATOM   1142  CD2 LEU A 290      75.188 165.412 -52.061  1.00 67.84           C  
ATOM   1143  N   VAL A 291      75.349 160.759 -53.769  1.00 72.32           N  
ATOM   1144  CA  VAL A 291      76.463 159.876 -53.436  1.00 74.43           C  
ATOM   1145  C   VAL A 291      77.649 160.583 -52.791  1.00 77.61           C  
ATOM   1146  O   VAL A 291      78.173 161.551 -53.336  1.00 78.59           O  
ATOM   1147  CB  VAL A 291      76.951 159.129 -54.680  1.00 73.16           C  
ATOM   1148  CG1 VAL A 291      78.064 158.166 -54.313  1.00 73.19           C  
ATOM   1149  CG2 VAL A 291      75.791 158.390 -55.325  1.00 73.50           C  
ATOM   1150  N   LYS A 292      78.058 160.105 -51.619  1.00 80.86           N  
ATOM   1151  CA  LYS A 292      79.197 160.685 -50.911  1.00 84.19           C  
ATOM   1152  C   LYS A 292      80.279 159.616 -50.749  1.00 87.11           C  
ATOM   1153  O   LYS A 292      79.966 158.455 -50.490  1.00 87.65           O  
ATOM   1154  CB  LYS A 292      78.791 161.199 -49.527  1.00 82.87           C  
ATOM   1155  CG  LYS A 292      77.438 161.873 -49.425  1.00 81.27           C  
ATOM   1156  CD  LYS A 292      76.379 160.868 -48.988  1.00 82.40           C  
ATOM   1157  CE  LYS A 292      75.207 161.542 -48.271  1.00 82.11           C  
ATOM   1158  NZ  LYS A 292      74.534 162.587 -49.094  1.00 82.17           N  
ATOM   1159  N   ASP A 293      81.545 160.006 -50.880  1.00 90.73           N  
ATOM   1160  CA  ASP A 293      82.661 159.062 -50.754  1.00 94.39           C  
ATOM   1161  C   ASP A 293      82.657 158.342 -49.402  1.00 95.85           C  
ATOM   1162  O   ASP A 293      82.502 158.978 -48.358  1.00 96.16           O  
ATOM   1163  CB  ASP A 293      84.001 159.784 -50.959  1.00 96.04           C  
ATOM   1164  CG  ASP A 293      85.162 158.819 -51.205  1.00 98.65           C  
ATOM   1165  OD1 ASP A 293      85.445 157.968 -50.329  1.00 99.42           O  
ATOM   1166  OD2 ASP A 293      85.793 158.907 -52.283  1.00 99.73           O  
ATOM   1167  N   SER A 294      82.847 157.019 -49.440  1.00 97.48           N  
ATOM   1168  CA  SER A 294      82.872 156.155 -48.243  1.00 98.97           C  
ATOM   1169  C   SER A 294      83.548 156.777 -47.009  1.00 99.73           C  
ATOM   1170  O   SER A 294      82.898 156.978 -45.974  1.00 99.73           O  
ATOM   1171  CB  SER A 294      83.547 154.808 -48.564  1.00 98.85           C  
ATOM   1172  OG  SER A 294      82.775 154.030 -49.465  1.00 97.51           O  
ATOM   1173  N   ALA A 295      84.846 157.068 -47.128  1.00 99.73           N  
ATOM   1174  CA  ALA A 295      85.623 157.668 -46.040  1.00 99.73           C  
ATOM   1175  C   ALA A 295      85.449 159.192 -45.953  1.00 99.15           C  
ATOM   1176  O   ALA A 295      84.879 159.693 -44.984  1.00 99.41           O  
ATOM   1177  CB  ALA A 295      87.105 157.302 -46.176  1.00 99.59           C  
ATOM   1178  N   THR A 296      85.938 159.906 -46.969  1.00 98.36           N  
ATOM   1179  CA  THR A 296      85.850 161.367 -47.070  1.00 96.87           C  
ATOM   1180  C   THR A 296      84.498 161.886 -46.602  1.00 96.33           C  
ATOM   1181  O   THR A 296      84.443 162.784 -45.769  1.00 96.23           O  
ATOM   1182  CB  THR A 296      86.075 161.838 -48.510  1.00 96.78           C  
ATOM   1183  OG1 THR A 296      87.092 161.029 -49.114  1.00 95.31           O  
ATOM   1184  CG2 THR A 296      86.530 163.293 -48.525  1.00 95.49           C  
ATOM   1185  N   GLY A 297      83.422 161.309 -47.178  1.00 95.56           N  
ATOM   1186  CA  GLY A 297      82.071 161.711 -46.815  1.00 94.51           C  
ATOM   1187  C   GLY A 297      81.436 162.867 -47.574  1.00 93.03           C  
ATOM   1188  O   GLY A 297      80.297 163.245 -47.279  1.00 93.84           O  
ATOM   1189  N   LEU A 298      82.167 163.477 -48.505  1.00 90.92           N  
ATOM   1190  CA  LEU A 298      81.595 164.582 -49.274  1.00 88.16           C  
ATOM   1191  C   LEU A 298      81.045 164.099 -50.609  1.00 85.61           C  
ATOM   1192  O   LEU A 298      81.281 162.962 -51.020  1.00 85.65           O  
ATOM   1193  CB  LEU A 298      82.598 165.720 -49.501  1.00 89.06           C  
ATOM   1194  CG  LEU A 298      84.021 165.643 -48.943  1.00 89.31           C  
ATOM   1195  CD1 LEU A 298      84.823 166.790 -49.517  1.00 88.78           C  
ATOM   1196  CD2 LEU A 298      84.033 165.690 -47.415  1.00 89.31           C  
ATOM   1197  N   SER A 299      80.318 164.981 -51.283  1.00 82.32           N  
ATOM   1198  CA  SER A 299      79.706 164.675 -52.564  1.00 78.61           C  
ATOM   1199  C   SER A 299      80.705 164.160 -53.590  1.00 76.87           C  
ATOM   1200  O   SER A 299      81.836 164.636 -53.657  1.00 77.70           O  
ATOM   1201  CB  SER A 299      79.014 165.921 -53.100  1.00 77.92           C  
ATOM   1202  OG  SER A 299      78.376 165.658 -54.329  1.00 79.88           O  
ATOM   1203  N   LYS A 300      80.288 163.153 -54.353  1.00 74.11           N  
ATOM   1204  CA  LYS A 300      81.118 162.569 -55.401  1.00 70.84           C  
ATOM   1205  C   LYS A 300      80.812 163.294 -56.709  1.00 68.24           C  
ATOM   1206  O   LYS A 300      81.351 162.938 -57.754  1.00 68.46           O  
ATOM   1207  CB  LYS A 300      80.819 161.074 -55.569  1.00 71.75           C  
ATOM   1208  CG  LYS A 300      81.018 160.222 -54.323  1.00 73.14           C  
ATOM   1209  CD  LYS A 300      82.417 159.628 -54.207  1.00 74.55           C  
ATOM   1210  CE  LYS A 300      82.685 158.517 -55.229  1.00 75.77           C  
ATOM   1211  NZ  LYS A 300      83.019 159.015 -56.607  1.00 75.87           N  
ATOM   1212  N   GLY A 301      79.896 164.261 -56.648  1.00 65.69           N  
ATOM   1213  CA  GLY A 301      79.526 165.049 -57.815  1.00 63.10           C  
ATOM   1214  C   GLY A 301      78.317 164.622 -58.626  1.00 61.62           C  
ATOM   1215  O   GLY A 301      78.054 165.197 -59.684  1.00 62.03           O  
ATOM   1216  N   TYR A 302      77.575 163.631 -58.138  1.00 61.59           N  
ATOM   1217  CA  TYR A 302      76.391 163.128 -58.835  1.00 59.33           C  
ATOM   1218  C   TYR A 302      75.335 162.575 -57.888  1.00 57.98           C  
ATOM   1219  O   TYR A 302      75.643 162.073 -56.807  1.00 56.77           O  
ATOM   1220  CB  TYR A 302      76.785 162.062 -59.861  1.00 61.84           C  
ATOM   1221  CG  TYR A 302      77.337 160.782 -59.268  1.00 62.65           C  
ATOM   1222  CD1 TYR A 302      76.490 159.722 -58.956  1.00 62.79           C  
ATOM   1223  CD2 TYR A 302      78.701 160.627 -59.022  1.00 62.18           C  
ATOM   1224  CE1 TYR A 302      76.980 158.549 -58.416  1.00 62.34           C  
ATOM   1225  CE2 TYR A 302      79.200 159.448 -58.479  1.00 61.34           C  
ATOM   1226  CZ  TYR A 302      78.327 158.419 -58.181  1.00 61.90           C  
ATOM   1227  OH  TYR A 302      78.781 157.253 -57.633  1.00 63.51           O  
ATOM   1228  N   ALA A 303      74.082 162.657 -58.314  1.00 58.03           N  
ATOM   1229  CA  ALA A 303      72.972 162.184 -57.504  1.00 57.93           C  
ATOM   1230  C   ALA A 303      71.855 161.565 -58.326  1.00 58.11           C  
ATOM   1231  O   ALA A 303      71.794 161.713 -59.546  1.00 58.49           O  
ATOM   1232  CB  ALA A 303      72.426 163.312 -56.678  1.00 58.76           C  
ATOM   1233  N   PHE A 304      70.959 160.879 -57.631  1.00 58.12           N  
ATOM   1234  CA  PHE A 304      69.831 160.225 -58.264  1.00 58.00           C  
ATOM   1235  C   PHE A 304      68.584 160.666 -57.550  1.00 57.23           C  
ATOM   1236  O   PHE A 304      68.581 160.807 -56.332  1.00 56.90           O  
ATOM   1237  CB  PHE A 304      69.961 158.700 -58.154  1.00 58.42           C  
ATOM   1238  CG  PHE A 304      71.203 158.156 -58.784  1.00 59.19           C  
ATOM   1239  CD1 PHE A 304      71.230 157.843 -60.136  1.00 60.71           C  
ATOM   1240  CD2 PHE A 304      72.360 157.990 -58.036  1.00 60.73           C  
ATOM   1241  CE1 PHE A 304      72.389 157.378 -60.737  1.00 61.23           C  
ATOM   1242  CE2 PHE A 304      73.529 157.525 -58.625  1.00 60.68           C  
ATOM   1243  CZ  PHE A 304      73.543 157.220 -59.980  1.00 62.19           C  
ATOM   1244  N   CYS A 305      67.520 160.870 -58.312  1.00 58.93           N  
ATOM   1245  CA  CYS A 305      66.237 161.279 -57.749  1.00 59.13           C  
ATOM   1246  C   CYS A 305      65.101 160.739 -58.613  1.00 59.25           C  
ATOM   1247  O   CYS A 305      65.336 160.072 -59.616  1.00 59.34           O  
ATOM   1248  CB  CYS A 305      66.143 162.802 -57.685  1.00 58.72           C  
ATOM   1249  SG  CYS A 305      65.745 163.557 -59.265  1.00 57.97           S  
ATOM   1250  N   GLU A 306      63.873 161.071 -58.237  1.00 60.67           N  
ATOM   1251  CA  GLU A 306      62.693 160.641 -58.973  1.00 61.43           C  
ATOM   1252  C   GLU A 306      61.476 161.389 -58.439  1.00 61.22           C  
ATOM   1253  O   GLU A 306      61.244 161.413 -57.234  1.00 60.84           O  
ATOM   1254  CB  GLU A 306      62.501 159.139 -58.805  1.00 63.75           C  
ATOM   1255  CG  GLU A 306      61.528 158.532 -59.780  1.00 66.83           C  
ATOM   1256  CD  GLU A 306      61.325 157.058 -59.526  1.00 68.12           C  
ATOM   1257  OE1 GLU A 306      60.992 156.711 -58.375  1.00 66.95           O  
ATOM   1258  OE2 GLU A 306      61.494 156.255 -60.472  1.00 68.52           O  
ATOM   1259  N   TYR A 307      60.728 162.026 -59.337  1.00 61.92           N  
ATOM   1260  CA  TYR A 307      59.538 162.788 -58.968  1.00 63.18           C  
ATOM   1261  C   TYR A 307      58.308 161.910 -58.775  1.00 65.73           C  
ATOM   1262  O   TYR A 307      58.241 160.787 -59.287  1.00 66.03           O  
ATOM   1263  CB  TYR A 307      59.212 163.814 -60.043  1.00 63.05           C  
ATOM   1264  CG  TYR A 307      60.320 164.789 -60.354  1.00 62.66           C  
ATOM   1265  CD1 TYR A 307      61.119 164.617 -61.478  1.00 61.82           C  
ATOM   1266  CD2 TYR A 307      60.546 165.904 -59.542  1.00 63.36           C  
ATOM   1267  CE1 TYR A 307      62.112 165.527 -61.792  1.00 63.75           C  
ATOM   1268  CE2 TYR A 307      61.543 166.826 -59.845  1.00 63.23           C  
ATOM   1269  CZ  TYR A 307      62.323 166.630 -60.973  1.00 64.69           C  
ATOM   1270  OH  TYR A 307      63.321 167.525 -61.288  1.00 66.48           O  
ATOM   1271  N   VAL A 308      57.322 162.449 -58.063  1.00 68.39           N  
ATOM   1272  CA  VAL A 308      56.073 161.739 -57.802  1.00 70.81           C  
ATOM   1273  C   VAL A 308      55.281 161.634 -59.106  1.00 73.05           C  
ATOM   1274  O   VAL A 308      54.892 160.540 -59.523  1.00 74.29           O  
ATOM   1275  CB  VAL A 308      55.227 162.463 -56.741  1.00 69.74           C  
ATOM   1276  CG1 VAL A 308      54.112 161.549 -56.262  1.00 70.48           C  
ATOM   1277  CG2 VAL A 308      56.101 162.895 -55.569  1.00 69.15           C  
ATOM   1278  N   ASP A 309      55.032 162.773 -59.743  1.00 75.28           N  
ATOM   1279  CA  ASP A 309      54.323 162.771 -61.015  1.00 78.15           C  
ATOM   1280  C   ASP A 309      55.385 162.455 -62.047  1.00 78.33           C  
ATOM   1281  O   ASP A 309      56.095 163.348 -62.506  1.00 78.06           O  
ATOM   1282  CB  ASP A 309      53.699 164.140 -61.306  1.00 81.03           C  
ATOM   1283  CG  ASP A 309      52.975 164.182 -62.651  1.00 83.51           C  
ATOM   1284  OD1 ASP A 309      53.359 165.009 -63.510  1.00 85.12           O  
ATOM   1285  OD2 ASP A 309      52.028 163.388 -62.853  1.00 85.13           O  
ATOM   1286  N   ILE A 310      55.486 161.181 -62.409  1.00 78.99           N  
ATOM   1287  CA  ILE A 310      56.493 160.723 -63.362  1.00 80.45           C  
ATOM   1288  C   ILE A 310      56.467 161.378 -64.741  1.00 80.87           C  
ATOM   1289  O   ILE A 310      57.279 161.054 -65.607  1.00 81.45           O  
ATOM   1290  CB  ILE A 310      56.477 159.186 -63.512  1.00 81.21           C  
ATOM   1291  CG1 ILE A 310      55.165 158.710 -64.142  1.00 81.45           C  
ATOM   1292  CG2 ILE A 310      56.717 158.534 -62.146  1.00 81.63           C  
ATOM   1293  CD1 ILE A 310      53.941 158.848 -63.242  1.00 84.52           C  
ATOM   1294  N   ASN A 311      55.545 162.309 -64.937  1.00 81.96           N  
ATOM   1295  CA  ASN A 311      55.440 163.011 -66.202  1.00 83.03           C  
ATOM   1296  C   ASN A 311      56.350 164.220 -66.210  1.00 83.20           C  
ATOM   1297  O   ASN A 311      56.849 164.616 -67.263  1.00 84.16           O  
ATOM   1298  CB  ASN A 311      53.995 163.431 -66.468  1.00 84.80           C  
ATOM   1299  CG  ASN A 311      53.101 162.250 -66.777  1.00 85.84           C  
ATOM   1300  OD1 ASN A 311      53.029 161.799 -67.924  1.00 85.98           O  
ATOM   1301  ND2 ASN A 311      52.434 161.722 -65.751  1.00 86.50           N  
ATOM   1302  N   VAL A 312      56.579 164.799 -65.034  1.00 83.17           N  
ATOM   1303  CA  VAL A 312      57.450 165.966 -64.923  1.00 84.02           C  
ATOM   1304  C   VAL A 312      58.918 165.617 -65.201  1.00 83.33           C  
ATOM   1305  O   VAL A 312      59.764 166.504 -65.301  1.00 82.83           O  
ATOM   1306  CB  VAL A 312      57.350 166.630 -63.529  1.00 85.38           C  
ATOM   1307  CG1 VAL A 312      55.903 166.937 -63.184  1.00 87.17           C  
ATOM   1308  CG2 VAL A 312      57.968 165.749 -62.477  1.00 85.66           C  
ATOM   1309  N   THR A 313      59.204 164.324 -65.345  1.00 83.30           N  
ATOM   1310  CA  THR A 313      60.558 163.841 -65.608  1.00 83.39           C  
ATOM   1311  C   THR A 313      61.205 164.504 -66.825  1.00 84.51           C  
ATOM   1312  O   THR A 313      62.310 165.044 -66.727  1.00 85.83           O  
ATOM   1313  CB  THR A 313      60.587 162.307 -65.789  1.00 81.75           C  
ATOM   1314  OG1 THR A 313      60.135 161.670 -64.587  1.00 79.78           O  
ATOM   1315  CG2 THR A 313      61.991 161.841 -66.083  1.00 81.84           C  
ATOM   1316  N   ASP A 314      60.511 164.485 -67.959  1.00 84.53           N  
ATOM   1317  CA  ASP A 314      61.039 165.091 -69.178  1.00 84.52           C  
ATOM   1318  C   ASP A 314      61.165 166.605 -69.058  1.00 84.23           C  
ATOM   1319  O   ASP A 314      62.132 167.188 -69.548  1.00 83.67           O  
ATOM   1320  CB  ASP A 314      60.170 164.722 -70.375  1.00 84.74           C  
ATOM   1321  CG  ASP A 314      60.047 163.230 -70.551  1.00 85.60           C  
ATOM   1322  OD1 ASP A 314      60.962 162.625 -71.150  1.00 85.73           O  
ATOM   1323  OD2 ASP A 314      59.048 162.661 -70.062  1.00 86.43           O  
ATOM   1324  N   GLN A 315      60.189 167.235 -68.407  1.00 83.99           N  
ATOM   1325  CA  GLN A 315      60.212 168.683 -68.212  1.00 84.63           C  
ATOM   1326  C   GLN A 315      61.431 169.064 -67.378  1.00 83.44           C  
ATOM   1327  O   GLN A 315      62.067 170.089 -67.629  1.00 83.35           O  
ATOM   1328  CB  GLN A 315      58.939 169.163 -67.510  1.00 87.12           C  
ATOM   1329  CG  GLN A 315      57.656 168.982 -68.314  1.00 89.56           C  
ATOM   1330  CD  GLN A 315      56.418 169.420 -67.542  1.00 91.62           C  
ATOM   1331  OE1 GLN A 315      56.087 168.847 -66.498  1.00 93.30           O  
ATOM   1332  NE2 GLN A 315      55.727 170.440 -68.051  1.00 91.88           N  
ATOM   1333  N   ALA A 316      61.753 168.218 -66.399  1.00 81.87           N  
ATOM   1334  CA  ALA A 316      62.903 168.427 -65.527  1.00 78.85           C  
ATOM   1335  C   ALA A 316      64.200 168.186 -66.286  1.00 77.35           C  
ATOM   1336  O   ALA A 316      65.177 168.898 -66.073  1.00 76.90           O  
ATOM   1337  CB  ALA A 316      62.826 167.519 -64.324  1.00 77.81           C  
ATOM   1338  N   ILE A 317      64.216 167.186 -67.167  1.00 75.73           N  
ATOM   1339  CA  ILE A 317      65.421 166.908 -67.944  1.00 75.65           C  
ATOM   1340  C   ILE A 317      65.747 168.124 -68.801  1.00 76.17           C  
ATOM   1341  O   ILE A 317      66.853 168.654 -68.734  1.00 76.65           O  
ATOM   1342  CB  ILE A 317      65.277 165.670 -68.872  1.00 74.71           C  
ATOM   1343  CG1 ILE A 317      65.047 164.401 -68.051  1.00 74.49           C  
ATOM   1344  CG2 ILE A 317      66.532 165.492 -69.709  1.00 72.47           C  
ATOM   1345  CD1 ILE A 317      64.871 163.152 -68.898  1.00 73.11           C  
ATOM   1346  N   ALA A 318      64.765 168.591 -69.566  1.00 76.96           N  
ATOM   1347  CA  ALA A 318      64.956 169.749 -70.439  1.00 76.89           C  
ATOM   1348  C   ALA A 318      65.494 170.952 -69.672  1.00 76.50           C  
ATOM   1349  O   ALA A 318      66.560 171.476 -69.996  1.00 75.27           O  
ATOM   1350  CB  ALA A 318      63.650 170.109 -71.134  1.00 76.26           C  
ATOM   1351  N   GLY A 319      64.780 171.332 -68.614  1.00 77.23           N  
ATOM   1352  CA  GLY A 319      65.167 172.478 -67.806  1.00 77.78           C  
ATOM   1353  C   GLY A 319      66.495 172.412 -67.072  1.00 78.36           C  
ATOM   1354  O   GLY A 319      67.259 173.383 -67.079  1.00 79.00           O  
ATOM   1355  N   LEU A 320      66.789 171.263 -66.468  1.00 77.60           N  
ATOM   1356  CA  LEU A 320      68.012 171.093 -65.701  1.00 76.14           C  
ATOM   1357  C   LEU A 320      69.261 170.666 -66.465  1.00 77.04           C  
ATOM   1358  O   LEU A 320      70.359 171.119 -66.140  1.00 78.03           O  
ATOM   1359  CB  LEU A 320      67.761 170.145 -64.533  1.00 75.06           C  
ATOM   1360  CG  LEU A 320      66.700 170.619 -63.538  1.00 73.98           C  
ATOM   1361  CD1 LEU A 320      66.482 169.588 -62.447  1.00 73.37           C  
ATOM   1362  CD2 LEU A 320      67.129 171.939 -62.941  1.00 75.15           C  
ATOM   1363  N   ASN A 321      69.109 169.807 -67.472  1.00 76.76           N  
ATOM   1364  CA  ASN A 321      70.261 169.329 -68.247  1.00 76.63           C  
ATOM   1365  C   ASN A 321      71.019 170.485 -68.879  1.00 76.62           C  
ATOM   1366  O   ASN A 321      70.411 171.425 -69.383  1.00 76.74           O  
ATOM   1367  CB  ASN A 321      69.813 168.335 -69.330  1.00 76.13           C  
ATOM   1368  CG  ASN A 321      70.984 167.647 -70.036  1.00 76.27           C  
ATOM   1369  OD1 ASN A 321      72.000 167.314 -69.422  1.00 75.16           O  
ATOM   1370  ND2 ASN A 321      70.824 167.405 -71.331  1.00 77.63           N  
ATOM   1371  N   GLY A 322      72.346 170.433 -68.792  1.00 77.68           N  
ATOM   1372  CA  GLY A 322      73.181 171.472 -69.372  1.00 79.91           C  
ATOM   1373  C   GLY A 322      73.342 172.756 -68.573  1.00 81.85           C  
ATOM   1374  O   GLY A 322      74.225 173.560 -68.882  1.00 82.12           O  
ATOM   1375  N   MET A 323      72.501 172.953 -67.555  1.00 83.33           N  
ATOM   1376  CA  MET A 323      72.555 174.144 -66.706  1.00 84.30           C  
ATOM   1377  C   MET A 323      73.961 174.349 -66.142  1.00 85.03           C  
ATOM   1378  O   MET A 323      74.678 173.386 -65.859  1.00 85.11           O  
ATOM   1379  CB  MET A 323      71.544 174.022 -65.556  1.00 85.36           C  
ATOM   1380  CG  MET A 323      71.490 175.216 -64.596  1.00 86.69           C  
ATOM   1381  SD  MET A 323      70.482 174.901 -63.096  1.00 90.47           S  
ATOM   1382  CE  MET A 323      69.522 176.424 -62.960  1.00 89.22           C  
ATOM   1383  N   GLN A 324      74.361 175.611 -66.025  1.00 85.86           N  
ATOM   1384  CA  GLN A 324      75.671 175.966 -65.497  1.00 86.50           C  
ATOM   1385  C   GLN A 324      75.592 176.094 -63.976  1.00 86.45           C  
ATOM   1386  O   GLN A 324      74.743 176.810 -63.449  1.00 86.55           O  
ATOM   1387  CB  GLN A 324      76.144 177.287 -66.115  1.00 87.48           C  
ATOM   1388  CG  GLN A 324      77.561 177.722 -65.730  1.00 88.81           C  
ATOM   1389  CD  GLN A 324      78.657 176.859 -66.349  1.00 89.35           C  
ATOM   1390  OE1 GLN A 324      79.690 176.610 -65.720  1.00 90.16           O  
ATOM   1391  NE2 GLN A 324      78.448 176.422 -67.591  1.00 87.95           N  
ATOM   1392  N   LEU A 325      76.449 175.349 -63.287  1.00 86.06           N  
ATOM   1393  CA  LEU A 325      76.530 175.350 -61.827  1.00 85.87           C  
ATOM   1394  C   LEU A 325      78.010 175.462 -61.492  1.00 86.32           C  
ATOM   1395  O   LEU A 325      78.778 174.529 -61.748  1.00 87.18           O  
ATOM   1396  CB  LEU A 325      75.992 174.038 -61.252  1.00 85.49           C  
ATOM   1397  CG  LEU A 325      74.593 173.998 -60.646  1.00 84.96           C  
ATOM   1398  CD1 LEU A 325      74.474 175.060 -59.577  1.00 86.51           C  
ATOM   1399  CD2 LEU A 325      73.547 174.202 -61.718  1.00 85.77           C  
ATOM   1400  N   GLY A 326      78.414 176.580 -60.899  1.00 85.84           N  
ATOM   1401  CA  GLY A 326      79.821 176.760 -60.598  1.00 84.93           C  
ATOM   1402  C   GLY A 326      80.528 176.759 -61.942  1.00 85.14           C  
ATOM   1403  O   GLY A 326      80.050 177.391 -62.893  1.00 85.51           O  
ATOM   1404  N   ASP A 327      81.637 176.034 -62.043  1.00 84.46           N  
ATOM   1405  CA  ASP A 327      82.367 175.944 -63.307  1.00 84.11           C  
ATOM   1406  C   ASP A 327      82.075 174.606 -63.985  1.00 84.84           C  
ATOM   1407  O   ASP A 327      82.891 174.096 -64.756  1.00 85.26           O  
ATOM   1408  CB  ASP A 327      83.875 176.105 -63.081  1.00 83.94           C  
ATOM   1409  CG  ASP A 327      84.439 175.110 -62.074  1.00 83.75           C  
ATOM   1410  OD1 ASP A 327      83.674 174.301 -61.508  1.00 84.52           O  
ATOM   1411  OD2 ASP A 327      85.667 175.149 -61.842  1.00 84.36           O  
ATOM   1412  N   LYS A 328      80.911 174.038 -63.676  1.00 84.98           N  
ATOM   1413  CA  LYS A 328      80.502 172.754 -64.236  1.00 85.13           C  
ATOM   1414  C   LYS A 328      79.189 172.815 -64.998  1.00 84.02           C  
ATOM   1415  O   LYS A 328      78.313 173.623 -64.695  1.00 82.67           O  
ATOM   1416  CB  LYS A 328      80.365 171.701 -63.130  1.00 85.87           C  
ATOM   1417  CG  LYS A 328      81.656 171.287 -62.463  1.00 86.56           C  
ATOM   1418  CD  LYS A 328      81.381 170.194 -61.459  1.00 88.03           C  
ATOM   1419  CE  LYS A 328      82.656 169.667 -60.824  1.00 89.01           C  
ATOM   1420  NZ  LYS A 328      82.352 168.534 -59.897  1.00 89.89           N  
ATOM   1421  N   LYS A 329      79.079 171.959 -66.009  1.00 84.11           N  
ATOM   1422  CA  LYS A 329      77.865 171.859 -66.802  1.00 84.30           C  
ATOM   1423  C   LYS A 329      77.097 170.645 -66.298  1.00 82.62           C  
ATOM   1424  O   LYS A 329      77.636 169.539 -66.186  1.00 81.59           O  
ATOM   1425  CB  LYS A 329      78.169 171.765 -68.306  1.00 86.37           C  
ATOM   1426  CG  LYS A 329      79.500 171.096 -68.679  1.00 90.76           C  
ATOM   1427  CD  LYS A 329      79.469 169.570 -68.529  1.00 93.99           C  
ATOM   1428  CE  LYS A 329      80.796 168.933 -68.948  1.00 96.20           C  
ATOM   1429  NZ  LYS A 329      80.805 167.450 -68.748  1.00 97.30           N  
ATOM   1430  N   LEU A 330      75.858 170.889 -65.900  1.00 80.87           N  
ATOM   1431  CA  LEU A 330      75.001 169.842 -65.383  1.00 79.87           C  
ATOM   1432  C   LEU A 330      74.651 168.812 -66.463  1.00 79.56           C  
ATOM   1433  O   LEU A 330      74.631 169.120 -67.661  1.00 80.65           O  
ATOM   1434  CB  LEU A 330      73.730 170.473 -64.821  1.00 78.45           C  
ATOM   1435  CG  LEU A 330      73.061 169.753 -63.658  1.00 77.85           C  
ATOM   1436  CD1 LEU A 330      74.025 169.682 -62.486  1.00 78.08           C  
ATOM   1437  CD2 LEU A 330      71.798 170.496 -63.259  1.00 77.33           C  
ATOM   1438  N   LEU A 331      74.422 167.577 -66.032  1.00 77.89           N  
ATOM   1439  CA  LEU A 331      74.056 166.496 -66.936  1.00 75.96           C  
ATOM   1440  C   LEU A 331      72.883 165.746 -66.335  1.00 75.91           C  
ATOM   1441  O   LEU A 331      73.016 165.098 -65.292  1.00 76.24           O  
ATOM   1442  CB  LEU A 331      75.224 165.531 -67.147  1.00 75.85           C  
ATOM   1443  CG  LEU A 331      74.894 164.221 -67.874  1.00 74.99           C  
ATOM   1444  CD1 LEU A 331      74.287 164.507 -69.235  1.00 74.98           C  
ATOM   1445  CD2 LEU A 331      76.143 163.370 -68.010  1.00 75.50           C  
ATOM   1446  N   VAL A 332      71.732 165.847 -66.993  1.00 74.75           N  
ATOM   1447  CA  VAL A 332      70.527 165.179 -66.529  1.00 72.62           C  
ATOM   1448  C   VAL A 332      69.945 164.273 -67.606  1.00 72.22           C  
ATOM   1449  O   VAL A 332      69.709 164.690 -68.737  1.00 72.63           O  
ATOM   1450  CB  VAL A 332      69.484 166.189 -66.072  1.00 71.86           C  
ATOM   1451  CG1 VAL A 332      68.275 165.475 -65.498  1.00 71.90           C  
ATOM   1452  CG2 VAL A 332      70.102 167.113 -65.042  1.00 71.43           C  
ATOM   1453  N   GLN A 333      69.721 163.020 -67.231  1.00 71.06           N  
ATOM   1454  CA  GLN A 333      69.185 162.005 -68.125  1.00 69.18           C  
ATOM   1455  C   GLN A 333      68.630 160.880 -67.253  1.00 69.58           C  
ATOM   1456  O   GLN A 333      69.001 160.753 -66.090  1.00 70.42           O  
ATOM   1457  CB  GLN A 333      70.316 161.469 -68.995  1.00 68.15           C  
ATOM   1458  CG  GLN A 333      71.451 160.861 -68.188  1.00 68.31           C  
ATOM   1459  CD  GLN A 333      72.699 160.589 -69.014  1.00 68.48           C  
ATOM   1460  OE1 GLN A 333      72.846 161.093 -70.130  1.00 66.79           O  
ATOM   1461  NE2 GLN A 333      73.613 159.792 -68.458  1.00 67.64           N  
ATOM   1462  N   ARG A 334      67.723 160.081 -67.802  1.00 68.49           N  
ATOM   1463  CA  ARG A 334      67.144 158.964 -67.060  1.00 67.15           C  
ATOM   1464  C   ARG A 334      68.309 158.038 -66.731  1.00 66.36           C  
ATOM   1465  O   ARG A 334      69.194 157.821 -67.550  1.00 64.35           O  
ATOM   1466  CB  ARG A 334      66.083 158.256 -67.906  1.00 66.79           C  
ATOM   1467  CG  ARG A 334      65.160 159.238 -68.647  1.00 65.18           C  
ATOM   1468  CD  ARG A 334      64.031 158.556 -69.374  1.00 64.37           C  
ATOM   1469  NE  ARG A 334      62.855 158.407 -68.527  1.00 63.64           N  
ATOM   1470  CZ  ARG A 334      61.850 159.277 -68.488  1.00 63.53           C  
ATOM   1471  NH1 ARG A 334      61.871 160.366 -69.251  1.00 63.19           N  
ATOM   1472  NH2 ARG A 334      60.820 159.057 -67.684  1.00 63.29           N  
ATOM   1473  N   ALA A 335      68.339 157.580 -65.487  1.00 67.50           N  
ATOM   1474  CA  ALA A 335      69.406 156.730 -64.977  1.00 68.84           C  
ATOM   1475  C   ALA A 335      69.418 155.303 -65.521  1.00 70.47           C  
ATOM   1476  O   ALA A 335      70.391 154.588 -65.302  1.00 70.20           O  
ATOM   1477  CB  ALA A 335      69.361 156.702 -63.436  1.00 68.66           C  
ATOM   1478  N   SER A 336      68.681 155.017 -66.592  1.00 73.23           N  
ATOM   1479  CA  SER A 336      68.638 153.633 -67.073  1.00 73.31           C  
ATOM   1480  C   SER A 336      68.681 153.484 -68.573  1.00 73.30           C  
ATOM   1481  O   SER A 336      69.695 153.947 -69.137  1.00 73.14           O  
ATOM   1482  CB  SER A 336      67.389 152.963 -66.520  1.00 74.74           C  
ATOM   1483  OG  SER A 336      67.454 151.562 -66.657  1.00 76.36           O  
ATOM   1484  OXT SER A 336      67.741 152.873 -69.140  1.00 74.77           O  
TER    1485      SER A 336                                                      
HETATM 1486  C1  DIO A  41      39.088 150.561 -70.563  1.00 65.07           C  
HETATM 1487  C2  DIO A  41      40.915 151.903 -71.457  1.00 67.29           C  
HETATM 1488  C1' DIO A  41      38.445 150.478 -71.936  1.00 66.32           C  
HETATM 1489  C2' DIO A  41      40.289 151.833 -72.844  1.00 68.60           C  
HETATM 1490  O1  DIO A  41      40.479 150.779 -70.712  1.00 65.19           O  
HETATM 1491  O1' DIO A  41      39.440 150.685 -72.929  1.00 67.32           O  
HETATM 1492  O   HOH B  10      44.419 137.060 -51.495  1.00 61.31           O  
HETATM 1493  O   HOH B  28      40.756 148.354 -69.405  1.00 79.05           O  
HETATM 1494  O   HOH B  29      52.118 136.920 -55.974  1.00 74.31           O  
HETATM 1495  O   HOH A   1      64.647 128.175 -75.629  1.00 34.55           O  
HETATM 1496  O   HOH A   2      56.044 136.472 -61.729  1.00 69.13           O  
HETATM 1497  O   HOH A   3      56.214 145.578 -66.469  1.00 54.76           O  
HETATM 1498  O   HOH A   4      52.618 151.055 -69.530  1.00 41.29           O  
HETATM 1499  O   HOH A   5      41.402 125.819 -76.133  1.00 58.57           O  
HETATM 1500  O   HOH A   6      45.710 133.705 -83.801  1.00 65.74           O  
HETATM 1501  O   HOH A   7      62.716 135.733 -78.832  1.00 55.12           O  
HETATM 1502  O   HOH A   8      57.784 141.008 -82.860  1.00 58.32           O  
HETATM 1503  O   HOH A   9      62.771 156.026 -67.085  1.00 75.36           O  
HETATM 1504  O   HOH A  11      51.839 123.317 -73.063  1.00 70.55           O  
HETATM 1505  O   HOH A  12      41.623 125.892 -67.776  1.00 50.18           O  
HETATM 1506  O   HOH A  13      56.907 144.605 -77.906  1.00 58.72           O  
HETATM 1507  O   HOH A  14      29.964 137.928 -66.999  1.00 59.22           O  
HETATM 1508  O   HOH A  15      77.108 168.048 -54.037  1.00 67.26           O  
HETATM 1509  O   HOH A  16      44.177 124.383 -68.933  1.00 66.33           O  
HETATM 1510  O   HOH A  17      61.227 161.181 -61.866  1.00 51.65           O  
HETATM 1511  O   HOH A  18      76.061 157.304 -50.916  1.00 57.06           O  
HETATM 1512  O   HOH A  19      52.053 144.781 -65.448  1.00 71.72           O  
HETATM 1513  O   HOH A  20      62.518 161.765 -49.597  1.00 69.00           O  
HETATM 1514  O   HOH A  21      42.573 123.084 -74.916  1.00 59.76           O  
HETATM 1515  O   HOH A  22      77.537 174.976 -69.715  1.00 86.69           O  
HETATM 1516  O   HOH A  23      60.408 126.811 -70.177  1.00 62.86           O  
HETATM 1517  O   HOH A  24      79.200 167.654 -49.941  1.00 72.93           O  
HETATM 1518  O   HOH A  26      81.795 162.033 -43.887  1.00 58.52           O  
HETATM 1519  O   HOH A  27      57.141 141.970 -60.145  1.00 61.86           O  
HETATM 1520  O   HOH A  30      35.714 140.604 -71.460  1.00 75.78           O  
HETATM 1521  O   HOH A  31      33.665 138.433 -75.247  1.00 84.82           O  
CONECT 1486 1488 1490                                                           
CONECT 1487 1489 1490                                                           
CONECT 1488 1486 1491                                                           
CONECT 1489 1487 1491                                                           
CONECT 1490 1486 1487                                                           
CONECT 1491 1488 1489                                                           
MASTER      341    0    1    6   12    0    1    6 1509    2    6   15          
END

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Related entries of code: 2g4b

Entries with 90% protein sequence similarity cutoff in PDBbind
PDB Code	Check Database	Protein Sequence Similarity
No similar entries are found!
Complexes with the same small molecule ligand
PDB Code	Check Database	Ligand Name
1jbr	RCSB PDB PDBbind	RNA
1knz	RCSB PDB PDBbind	RNA
1kq2	RCSB PDB PDBbind	RNA
1mwi	RCSB PDB PDBbind	RNA
1n32	RCSB PDB PDBbind	RNA
1n33	RCSB PDB PDBbind	RNA
1n34	RCSB PDB PDBbind	RNA
1n36	RCSB PDB PDBbind	RNA
1rkj	RCSB PDB PDBbind	RNA
2b6g	RCSB PDB PDBbind	RNA

Entry Information

PDB ID	2g4b
Complex Type	Protein-Nucleic Acid
PDBbind Subset	general set
Protein Name	Splicing factor U2AF 65 kDa subunit
Ligand Name	RNA
EC.Number	E.C.-.-.-.-
Resolution	2.5(Å)
Affinity (Kd/Ki/IC50)	Kd=1.8uM
Release Year	2006
Protein/NA Sequence	Check fasta file
Primary Reference	Molecular Cell. (2006) 23, pp. 49-59

Links to External Databases

RCSB PDB	The mother database
PDBsum	Enhanced annotations on PDB entries
Pubchem	Comprehensive collection of chemical and biological data
UniProtKB AC	UniProt accession number (AC): P26368
Entrez Gene ID	NCBI Entrez Gene ID: 11338
ASD	Information of known allosteric effects of PDB entries

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