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HEADER    TRANSCRIPTION REGULATOR                 13-MAY-10   3N00              
TITLE     CRYSTAL STRUCTURE OF A DELETION MUTANT OF HUMAN REVERBA LIGAND BINDING
TITLE    2 DOMAIN BOUND WITH AN NCOR ID1 PEPTIDE DETERMINED TO 2.60A            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: REV-ERBA-ALPHA;                                            
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 1, V-ERBA-      
COMPND   5 RELATED PROTEIN 1, EAR-1;                                            
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: NUCLEAR RECEPTOR COREPRESSOR 1;                            
COMPND   9 CHAIN: B;                                                            
COMPND  10 FRAGMENT: CORNR BOX 2 RESIDUES 2045-2065;                            
COMPND  11 SYNONYM: N-COR1, N-COR;                                              
COMPND  12 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: NR1D1, EAR1, HREV, THRAL;                                      
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21DE3;                                   
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PET24;                                
SOURCE  10 MOL_ID: 2;                                                           
SOURCE  11 SYNTHETIC: YES;                                                      
SOURCE  12 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  13 ORGANISM_COMMON: HUMAN;                                              
SOURCE  14 ORGANISM_TAXID: 9606                                                 
KEYWDS    REVERBA NCORID1, ANTI-PARALLEL B-SHEET, TRANSCRIPTION REGULATOR       
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    R.GAMPE,R.NOLTE                                                       
REVDAT   3   16-AUG-17 3N00    1       SOURCE REMARK                            
REVDAT   2   21-JUL-10 3N00    1       JRNL                                     
REVDAT   1   30-JUN-10 3N00    0                                                
JRNL        AUTH   C.A.PHELAN,R.T.GAMPE,M.H.LAMBERT,D.J.PARKS,V.MONTANA,        
JRNL        AUTH 2 J.BYNUM,T.M.BRODERICK,X.HU,S.P.WILLIAMS,R.T.NOLTE,M.A.LAZAR  
JRNL        TITL   STRUCTURE OF REV-ERBALPHA BOUND TO N-COR REVEALS A UNIQUE    
JRNL        TITL 2 MECHANISM OF NUCLEAR RECEPTOR-CO-REPRESSOR INTERACTION.      
JRNL        REF    NAT.STRUCT.MOL.BIOL.          V.  17   808 2010              
JRNL        REFN                   ISSN 1545-9993                               
JRNL        PMID   20581824                                                     
JRNL        DOI    10.1038/NSMB.1860                                            
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 6.0.2                                         
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON                               
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 30.04                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.9                           
REMARK   3   NUMBER OF REFLECTIONS             : 7693                           
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.200                           
REMARK   3   R VALUE            (WORKING SET) : 0.199                           
REMARK   3   FREE R VALUE                     : 0.266                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.800                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 225                             
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.60                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.67                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 554                          
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 98.79                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2640                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 16                           
REMARK   3   BIN FREE R VALUE                    : 0.2620                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 1549                                    
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 62                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 32.00                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 39.15                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -0.01000                                             
REMARK   3    B22 (A**2) : -0.01000                                             
REMARK   3    B33 (A**2) : 0.01000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.320         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.206         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 10.170        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.948                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.918                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  1570 ; 0.010 ; 0.022       
REMARK   3   BOND LENGTHS OTHERS               (A):  1055 ; 0.001 ; 0.020       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  2116 ; 1.126 ; 1.967       
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  2564 ; 0.837 ; 3.000       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   201 ; 5.433 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):    63 ;28.156 ;23.175       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   274 ;15.115 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    12 ;22.934 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   255 ; 0.055 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  1730 ; 0.003 ; 0.020       
REMARK   3   GENERAL PLANES OTHERS             (A):   318 ; 0.001 ; 0.020       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  1012 ; 0.604 ; 1.500       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):   417 ; 0.067 ; 1.500       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  1610 ; 1.184 ; 2.000       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):   558 ; 1.591 ; 3.000       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):   506 ; 2.900 ; 4.500       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL                              
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : BABINET MODEL WITH MASK                              
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING   
REMARK   3  POSITIONS                                                           
REMARK   4                                                                      
REMARK   4 3N00 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-MAY-10.                  
REMARK 100 THE DEPOSITION ID IS D_1000059207.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : NULL                               
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 7.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 17-ID                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1                                  
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MAR CCD 165 MM                     
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 7921                               
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.600                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9                               
REMARK 200  DATA REDUNDANCY                : 10.90                              
REMARK 200  R MERGE                    (I) : 0.04900                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 50.5000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.69                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.4                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 9.80                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.29600                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 7.300                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: AMORE                                                 
REMARK 200 STARTING MODEL: 1DB1                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 41.53                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.10                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 1UL OF PRECIPITANT COMPOSED OF 6-9% OF   
REMARK 280  PEG 3350, 8% GLYCEROL, 200MM PROLINE, 80MM HEPES WAS MIXED WITH     
REMARK 280  1UL OF THE REV-ERBA NCOR COMPLEX AT 5-6 MG/LIT TO OBTAIN            
REMARK 280  DIFFRACTION GRADE CRYSTALS, PH 7.5, VAPOR DIFFUSION, TEMPERATURE    
REMARK 280  295K                                                                
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: H 3 2                            
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z                                                
REMARK 290       3555   -X+Y,-X,Z                                               
REMARK 290       4555   Y,X,-Z                                                  
REMARK 290       5555   X-Y,-Y,-Z                                               
REMARK 290       6555   -X,-X+Y,-Z                                              
REMARK 290       7555   X+2/3,Y+1/3,Z+1/3                                       
REMARK 290       8555   -Y+2/3,X-Y+1/3,Z+1/3                                    
REMARK 290       9555   -X+Y+2/3,-X+1/3,Z+1/3                                   
REMARK 290      10555   Y+2/3,X+1/3,-Z+1/3                                      
REMARK 290      11555   X-Y+2/3,-Y+1/3,-Z+1/3                                   
REMARK 290      12555   -X+2/3,-X+Y+1/3,-Z+1/3                                  
REMARK 290      13555   X+1/3,Y+2/3,Z+2/3                                       
REMARK 290      14555   -Y+1/3,X-Y+2/3,Z+2/3                                    
REMARK 290      15555   -X+Y+1/3,-X+2/3,Z+2/3                                   
REMARK 290      16555   Y+1/3,X+2/3,-Z+2/3                                      
REMARK 290      17555   X-Y+1/3,-Y+2/3,-Z+2/3                                   
REMARK 290      18555   -X+1/3,-X+Y+2/3,-Z+2/3                                  
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   7  1.000000  0.000000  0.000000       56.27500            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       32.49039            
REMARK 290   SMTRY3   7  0.000000  0.000000  1.000000       34.61100            
REMARK 290   SMTRY1   8 -0.500000 -0.866025  0.000000       56.27500            
REMARK 290   SMTRY2   8  0.866025 -0.500000  0.000000       32.49039            
REMARK 290   SMTRY3   8  0.000000  0.000000  1.000000       34.61100            
REMARK 290   SMTRY1   9 -0.500000  0.866025  0.000000       56.27500            
REMARK 290   SMTRY2   9 -0.866025 -0.500000  0.000000       32.49039            
REMARK 290   SMTRY3   9  0.000000  0.000000  1.000000       34.61100            
REMARK 290   SMTRY1  10 -0.500000  0.866025  0.000000       56.27500            
REMARK 290   SMTRY2  10  0.866025  0.500000  0.000000       32.49039            
REMARK 290   SMTRY3  10  0.000000  0.000000 -1.000000       34.61100            
REMARK 290   SMTRY1  11  1.000000  0.000000  0.000000       56.27500            
REMARK 290   SMTRY2  11  0.000000 -1.000000  0.000000       32.49039            
REMARK 290   SMTRY3  11  0.000000  0.000000 -1.000000       34.61100            
REMARK 290   SMTRY1  12 -0.500000 -0.866025  0.000000       56.27500            
REMARK 290   SMTRY2  12 -0.866025  0.500000  0.000000       32.49039            
REMARK 290   SMTRY3  12  0.000000  0.000000 -1.000000       34.61100            
REMARK 290   SMTRY1  13  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2  13  0.000000  1.000000  0.000000       64.98077            
REMARK 290   SMTRY3  13  0.000000  0.000000  1.000000       69.22200            
REMARK 290   SMTRY1  14 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  14  0.866025 -0.500000  0.000000       64.98077            
REMARK 290   SMTRY3  14  0.000000  0.000000  1.000000       69.22200            
REMARK 290   SMTRY1  15 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  15 -0.866025 -0.500000  0.000000       64.98077            
REMARK 290   SMTRY3  15  0.000000  0.000000  1.000000       69.22200            
REMARK 290   SMTRY1  16 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  16  0.866025  0.500000  0.000000       64.98077            
REMARK 290   SMTRY3  16  0.000000  0.000000 -1.000000       69.22200            
REMARK 290   SMTRY1  17  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2  17  0.000000 -1.000000  0.000000       64.98077            
REMARK 290   SMTRY3  17  0.000000  0.000000 -1.000000       69.22200            
REMARK 290   SMTRY1  18 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  18 -0.866025  0.500000  0.000000       64.98077            
REMARK 290   SMTRY3  18  0.000000  0.000000 -1.000000       69.22200            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5470 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 18680 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -48.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000      194.94232            
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000      103.83300            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 2040 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 10030 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -17.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   271                                                      
REMARK 465     LYS A   272                                                      
REMARK 465     LYS A   273                                                      
REMARK 465     HIS A   274                                                      
REMARK 465     HIS A   275                                                      
REMARK 465     HIS A   276                                                      
REMARK 465     HIS A   277                                                      
REMARK 465     HIS A   278                                                      
REMARK 465     HIS A   279                                                      
REMARK 465     GLY A   280                                                      
REMARK 465     PRO A   281                                                      
REMARK 465     GLU A   282                                                      
REMARK 465     THR A   400                                                      
REMARK 465     TYR A   401                                                      
REMARK 465     ALA A   402                                                      
REMARK 465     HIS A   403                                                      
REMARK 465     ASP A   404                                                      
REMARK 465     LYS A   405                                                      
REMARK 465     LEU A   406                                                      
REMARK 465     GLY A   407                                                      
REMARK 465     SER A   408                                                      
REMARK 465     SER A   409                                                      
REMARK 465     PRO A   410                                                      
REMARK 465     GLY A   411                                                      
REMARK 465     ASN A   412                                                      
REMARK 465     PHE A   413                                                      
REMARK 465     ASN A   414                                                      
REMARK 465     ALA A   415                                                      
REMARK 465     ASN A   416                                                      
REMARK 465     HIS A   417                                                      
REMARK 465     ALA A   418                                                      
REMARK 465     SER A   419                                                      
REMARK 465     GLY A   420                                                      
REMARK 465     SER A   421                                                      
REMARK 465     PRO A   422                                                      
REMARK 465     TYR A   423                                                      
REMARK 465     PRO A   424                                                      
REMARK 465     HIS A   425                                                      
REMARK 465     GLY A   426                                                      
REMARK 465     ARG A   427                                                      
REMARK 465     SER A   428                                                      
REMARK 465     GLY A   429                                                      
REMARK 465     ARG A   430                                                      
REMARK 465     THR A   431                                                      
REMARK 465     GLN A   493                                                      
REMARK 465     THR A   494                                                      
REMARK 465     VAL A   495                                                      
REMARK 465     MET A   496                                                      
REMARK 465     PHE A   497                                                      
REMARK 465     LEU A   498                                                      
REMARK 465     SER A   499                                                      
REMARK 465     ARG A   500                                                      
REMARK 465     THR A   501                                                      
REMARK 465     THR A   502                                                      
REMARK 465     TYR A   503                                                      
REMARK 465     SER A   504                                                      
REMARK 465     LEU A   505                                                      
REMARK 465     GLN A   506                                                      
REMARK 465     ASP A   612                                                      
REMARK 465     ALA A   613                                                      
REMARK 465     GLN A   614                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU A 286    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 294    CZ   NH1  NH2                                       
REMARK 470     GLU A 434    CG   CD   OE1  OE2                                  
REMARK 470     ILE A 435    CG2  CD1                                            
REMARK 470     ASP A 438    CB   CG   OD1  OD2                                  
REMARK 470     SER A 442    OG                                                  
REMARK 470     PHE A 484    CD1  CD2  CE1  CE2  CZ                              
REMARK 470     ALA A 485    CB                                                  
REMARK 470     LEU A 487    CG   CD1  CD2                                       
REMARK 470     PHE A 488    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN A 489    CB   CG   OD1  ND2                                  
REMARK 470     VAL A 490    CB   CG1  CG2                                       
REMARK 470     LYS A 491    CB   CG   CD   CE   NZ                              
REMARK 470     ASP A 492    CB   CG   OD1  OD2                                  
REMARK 470     GLU A 507    CB   CG   CD   OE1  OE2                             
REMARK 470     MET A 513    CG   SD   CE                                        
REMARK 470     LEU A 517    CG   CD1  CD2                                       
REMARK 470     SER A 518    CB   OG                                             
REMARK 470     PHE A 521    CE1  CE2  CZ                                        
REMARK 470     ASP A 522    OD1  OD2                                            
REMARK 470     GLU A 525    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 564    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 576    NZ                                                  
REMARK 470     ARG A 610    CZ   NH1  NH2                                       
REMARK 470     GLN B2061    CG   CD   OE1  NE2                                  
REMARK 470     ARG B2065    O                                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A 487       24.81    -75.07                                   
REMARK 500    PHE A 488     -128.97    -94.00                                   
REMARK 500    ASN A 489     -151.69   -171.08                                   
REMARK 500    LYS A 491      -73.86    -67.98                                   
REMARK 500    LEU A 516      -72.79    -73.10                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 VAL A  432     GLN A  433                  149.73                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 2VOV   RELATED DB: PDB                                   
REMARK 900 CRYSTAL STRUCTURE OF A DELETION MUTANT OF APO HUMAN REVERBB LIGAND   
REMARK 900 BINDING DOMAIN DETERMINED TO 2.40A                                   
REMARK 900 RELATED ID: 3CQV   RELATED DB: PDB                                   
REMARK 900 CRYSTAL STRUCTURE OF HEME BOUND HUMAN REVERBB LIGAND BINDING DOMAIN  
REMARK 900 BOUND DETERMINED TO 1.90A                                            
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 RESIDUES 324-422 WERE DELETED IN THIS CONSTRUCT.                     
DBREF  3N00 A  281   422  UNP    P20393   NR1D1_HUMAN    281    323             
DBREF  3N00 A  423   614  UNP    P20393   NR1D1_HUMAN    423    614             
DBREF  3N00 B 2045  2065  UNP    O75376   NCOR1_HUMAN   2045   2065             
SEQADV 3N00 MET A  271  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 LYS A  272  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 LYS A  273  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 HIS A  274  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 HIS A  275  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 HIS A  276  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 HIS A  277  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 HIS A  278  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 HIS A  279  UNP  P20393              EXPRESSION TAG                 
SEQADV 3N00 GLY A  280  UNP  P20393              EXPRESSION TAG                 
SEQRES   1 A  245  MET LYS LYS HIS HIS HIS HIS HIS HIS GLY PRO GLU PRO          
SEQRES   2 A  245  THR VAL GLU ASP VAL ILE SER GLN VAL ALA ARG ALA HIS          
SEQRES   3 A  245  ARG GLU ILE PHE THR TYR ALA HIS ASP LYS LEU GLY SER          
SEQRES   4 A  245  SER PRO GLY ASN PHE ASN ALA ASN HIS ALA SER GLY SER          
SEQRES   5 A  245  PRO TYR PRO HIS GLY ARG SER GLY ARG THR VAL GLN GLU          
SEQRES   6 A  245  ILE TRP GLU ASP PHE SER MET SER PHE THR PRO ALA VAL          
SEQRES   7 A  245  ARG GLU VAL VAL GLU PHE ALA LYS HIS ILE PRO GLY PHE          
SEQRES   8 A  245  ARG ASP LEU SER GLN HIS ASP GLN VAL THR LEU LEU LYS          
SEQRES   9 A  245  ALA GLY THR PHE GLU VAL LEU MET VAL ARG PHE ALA SER          
SEQRES  10 A  245  LEU PHE ASN VAL LYS ASP GLN THR VAL MET PHE LEU SER          
SEQRES  11 A  245  ARG THR THR TYR SER LEU GLN GLU LEU GLY ALA MET GLY          
SEQRES  12 A  245  MET GLY ASP LEU LEU SER ALA MET PHE ASP PHE SER GLU          
SEQRES  13 A  245  LYS LEU ASN SER LEU ALA LEU THR GLU GLU GLU LEU GLY          
SEQRES  14 A  245  LEU PHE THR ALA VAL VAL LEU VAL SER ALA ASP ARG SER          
SEQRES  15 A  245  GLY MET GLU ASN SER ALA SER VAL GLU GLN LEU GLN GLU          
SEQRES  16 A  245  THR LEU LEU ARG ALA LEU ARG ALA LEU VAL LEU LYS ASN          
SEQRES  17 A  245  ARG PRO LEU GLU THR SER ARG PHE THR LYS LEU LEU LEU          
SEQRES  18 A  245  LYS LEU PRO ASP LEU ARG THR LEU ASN ASN MET HIS SER          
SEQRES  19 A  245  GLU LYS LEU LEU SER PHE ARG VAL ASP ALA GLN                  
SEQRES   1 B   21  THR HIS ARG LEU ILE THR LEU ALA ASP HIS ILE CYS GLN          
SEQRES   2 B   21  ILE ILE THR GLN ASP PHE ALA ARG                              
FORMUL   3  HOH   *62(H2 O)                                                     
HELIX    1   1 THR A  284  PHE A  300  1                                  17    
HELIX    2   2 GLN A  433  ILE A  457  1                                  25    
HELIX    3   3 GLY A  459  LEU A  463  5                                   5    
HELIX    4   4 SER A  464  LEU A  487  1                                  24    
HELIX    5   5 LEU A  508  GLY A  512  5                                   5    
HELIX    6   6 MET A  513  LEU A  530  1                                  18    
HELIX    7   7 THR A  533  SER A  547  1                                  15    
HELIX    8   8 ASN A  555  ARG A  578  1                                  24    
HELIX    9   9 SER A  583  LEU A  590  1                                   8    
HELIX   10  10 LEU A  590  SER A  603  1                                  14    
HELIX   11  11 LEU B 2051  ARG B 2065  1                                  15    
SHEET    1   A 2 LEU A 606  ARG A 610  0                                        
SHEET    2   A 2 HIS B2046  THR B2050 -1  O  ILE B2049   N  LEU A 607           
CRYST1  112.550  112.550  103.833  90.00  90.00 120.00 H 3 2        18          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.008885  0.005130  0.000000        0.00000                         
SCALE2      0.000000  0.010259  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.009631        0.00000                         
ATOM      1  N   PRO A 283     -20.157  54.411  36.291  1.00 57.41           N  
ATOM      2  CA  PRO A 283     -20.483  53.239  37.100  1.00 57.06           C  
ATOM      3  C   PRO A 283     -21.979  53.184  37.401  1.00 56.35           C  
ATOM      4  O   PRO A 283     -22.759  53.950  36.811  1.00 56.35           O  
ATOM      5  CB  PRO A 283     -19.689  53.492  38.384  1.00 57.35           C  
ATOM      6  CG  PRO A 283     -19.759  55.007  38.549  1.00 57.78           C  
ATOM      7  CD  PRO A 283     -19.942  55.602  37.139  1.00 57.55           C  
ATOM      8  N   THR A 284     -22.369  52.308  38.322  1.00 55.36           N  
ATOM      9  CA  THR A 284     -23.785  52.073  38.583  1.00 54.75           C  
ATOM     10  C   THR A 284     -24.391  53.255  39.319  1.00 53.88           C  
ATOM     11  O   THR A 284     -23.712  53.917  40.090  1.00 54.18           O  
ATOM     12  CB  THR A 284     -23.997  50.797  39.407  1.00 54.80           C  
ATOM     13  OG1 THR A 284     -23.656  51.040  40.776  1.00 54.85           O  
ATOM     14  CG2 THR A 284     -23.136  49.660  38.853  1.00 55.21           C  
ATOM     15  N   VAL A 285     -25.671  53.516  39.084  1.00 52.87           N  
ATOM     16  CA  VAL A 285     -26.381  54.589  39.782  1.00 51.88           C  
ATOM     17  C   VAL A 285     -26.213  54.531  41.315  1.00 51.70           C  
ATOM     18  O   VAL A 285     -26.083  55.575  41.966  1.00 52.06           O  
ATOM     19  CB  VAL A 285     -27.866  54.575  39.426  1.00 51.52           C  
ATOM     20  CG1 VAL A 285     -28.637  55.514  40.315  1.00 51.51           C  
ATOM     21  CG2 VAL A 285     -28.047  54.950  37.977  1.00 51.01           C  
ATOM     22  N   GLU A 286     -26.181  53.322  41.880  1.00 51.18           N  
ATOM     23  CA  GLU A 286     -26.053  53.129  43.330  1.00 50.52           C  
ATOM     24  C   GLU A 286     -24.666  53.514  43.851  1.00 49.98           C  
ATOM     25  O   GLU A 286     -24.556  54.163  44.889  1.00 49.48           O  
ATOM     26  CB  GLU A 286     -26.378  51.678  43.706  1.00 50.62           C  
ATOM     27  N   ASP A 287     -23.622  53.112  43.128  1.00 49.62           N  
ATOM     28  CA  ASP A 287     -22.236  53.508  43.437  1.00 49.70           C  
ATOM     29  C   ASP A 287     -22.053  55.020  43.505  1.00 48.69           C  
ATOM     30  O   ASP A 287     -21.488  55.538  44.468  1.00 48.65           O  
ATOM     31  CB  ASP A 287     -21.278  52.999  42.359  1.00 50.27           C  
ATOM     32  CG  ASP A 287     -21.143  51.497  42.354  1.00 52.93           C  
ATOM     33  OD1 ASP A 287     -20.964  50.931  43.454  1.00 56.28           O  
ATOM     34  OD2 ASP A 287     -21.211  50.889  41.249  1.00 56.99           O  
ATOM     35  N   VAL A 288     -22.515  55.701  42.454  1.00 47.57           N  
ATOM     36  CA  VAL A 288     -22.444  57.153  42.350  1.00 46.72           C  
ATOM     37  C   VAL A 288     -23.139  57.814  43.538  1.00 46.20           C  
ATOM     38  O   VAL A 288     -22.523  58.624  44.232  1.00 45.69           O  
ATOM     39  CB  VAL A 288     -23.085  57.660  41.027  1.00 46.94           C  
ATOM     40  CG1 VAL A 288     -23.247  59.185  41.040  1.00 46.28           C  
ATOM     41  CG2 VAL A 288     -22.266  57.207  39.821  1.00 45.91           C  
ATOM     42  N   ILE A 289     -24.405  57.460  43.775  1.00 45.49           N  
ATOM     43  CA  ILE A 289     -25.146  57.997  44.919  1.00 45.44           C  
ATOM     44  C   ILE A 289     -24.380  57.771  46.222  1.00 45.67           C  
ATOM     45  O   ILE A 289     -24.216  58.686  47.036  1.00 45.48           O  
ATOM     46  CB  ILE A 289     -26.539  57.345  45.102  1.00 45.34           C  
ATOM     47  CG1 ILE A 289     -27.476  57.649  43.936  1.00 45.62           C  
ATOM     48  CG2 ILE A 289     -27.204  57.872  46.371  1.00 45.32           C  
ATOM     49  CD1 ILE A 289     -28.795  56.896  44.015  1.00 44.26           C  
ATOM     50  N   SER A 290     -23.935  56.533  46.416  1.00 46.05           N  
ATOM     51  CA  SER A 290     -23.225  56.133  47.627  1.00 46.42           C  
ATOM     52  C   SER A 290     -21.935  56.931  47.766  1.00 46.51           C  
ATOM     53  O   SER A 290     -21.706  57.584  48.781  1.00 46.72           O  
ATOM     54  CB  SER A 290     -22.921  54.632  47.583  1.00 46.52           C  
ATOM     55  OG  SER A 290     -21.855  54.278  48.445  1.00 47.79           O  
ATOM     56  N   GLN A 291     -21.112  56.898  46.727  1.00 46.51           N  
ATOM     57  CA  GLN A 291     -19.838  57.600  46.742  1.00 46.69           C  
ATOM     58  C   GLN A 291     -19.954  59.098  46.988  1.00 46.12           C  
ATOM     59  O   GLN A 291     -19.254  59.643  47.842  1.00 46.41           O  
ATOM     60  CB  GLN A 291     -19.107  57.373  45.432  1.00 47.12           C  
ATOM     61  CG  GLN A 291     -17.615  57.617  45.566  1.00 49.71           C  
ATOM     62  CD  GLN A 291     -16.819  57.007  44.436  1.00 51.98           C  
ATOM     63  OE1 GLN A 291     -17.107  55.885  43.985  1.00 54.04           O  
ATOM     64  NE2 GLN A 291     -15.810  57.746  43.962  1.00 52.65           N  
ATOM     65  N   VAL A 292     -20.833  59.763  46.241  1.00 45.50           N  
ATOM     66  CA  VAL A 292     -21.024  61.204  46.389  1.00 44.87           C  
ATOM     67  C   VAL A 292     -21.541  61.551  47.778  1.00 45.15           C  
ATOM     68  O   VAL A 292     -21.006  62.444  48.411  1.00 45.42           O  
ATOM     69  CB  VAL A 292     -21.988  61.790  45.330  1.00 44.62           C  
ATOM     70  CG1 VAL A 292     -22.421  63.214  45.712  1.00 43.78           C  
ATOM     71  CG2 VAL A 292     -21.356  61.753  43.946  1.00 43.76           C  
ATOM     72  N   ALA A 293     -22.570  60.838  48.244  1.00 45.45           N  
ATOM     73  CA  ALA A 293     -23.225  61.110  49.538  1.00 45.39           C  
ATOM     74  C   ALA A 293     -22.255  61.002  50.706  1.00 45.87           C  
ATOM     75  O   ALA A 293     -22.312  61.779  51.667  1.00 45.25           O  
ATOM     76  CB  ALA A 293     -24.364  60.155  49.737  1.00 44.97           C  
ATOM     77  N   ARG A 294     -21.364  60.024  50.594  1.00 46.80           N  
ATOM     78  CA  ARG A 294     -20.310  59.777  51.569  1.00 47.88           C  
ATOM     79  C   ARG A 294     -19.296  60.922  51.604  1.00 48.27           C  
ATOM     80  O   ARG A 294     -19.025  61.492  52.679  1.00 48.83           O  
ATOM     81  CB  ARG A 294     -19.617  58.464  51.213  1.00 48.17           C  
ATOM     82  CG  ARG A 294     -18.553  57.988  52.183  1.00 50.09           C  
ATOM     83  CD  ARG A 294     -18.155  56.528  51.853  1.00 51.81           C  
ATOM     84  NE  ARG A 294     -17.098  56.035  52.731  1.00 52.99           N  
ATOM     85  N   ALA A 295     -18.746  61.257  50.434  1.00 48.32           N  
ATOM     86  CA  ALA A 295     -17.845  62.403  50.303  1.00 48.52           C  
ATOM     87  C   ALA A 295     -18.488  63.669  50.862  1.00 48.79           C  
ATOM     88  O   ALA A 295     -17.852  64.400  51.601  1.00 49.38           O  
ATOM     89  CB  ALA A 295     -17.428  62.610  48.848  1.00 48.31           C  
ATOM     90  N   HIS A 296     -19.749  63.920  50.530  1.00 49.20           N  
ATOM     91  CA  HIS A 296     -20.461  65.079  51.058  1.00 49.76           C  
ATOM     92  C   HIS A 296     -20.544  65.043  52.586  1.00 51.23           C  
ATOM     93  O   HIS A 296     -20.338  66.065  53.242  1.00 51.71           O  
ATOM     94  CB  HIS A 296     -21.867  65.174  50.464  1.00 49.42           C  
ATOM     95  CG  HIS A 296     -22.611  66.414  50.855  1.00 47.78           C  
ATOM     96  ND1 HIS A 296     -23.698  66.393  51.698  1.00 47.22           N  
ATOM     97  CD2 HIS A 296     -22.434  67.708  50.507  1.00 47.39           C  
ATOM     98  CE1 HIS A 296     -24.158  67.621  51.857  1.00 47.65           C  
ATOM     99  NE2 HIS A 296     -23.407  68.439  51.145  1.00 47.58           N  
ATOM    100  N   ARG A 297     -20.836  63.876  53.155  1.00 52.60           N  
ATOM    101  CA  ARG A 297     -20.943  63.764  54.607  1.00 53.75           C  
ATOM    102  C   ARG A 297     -19.602  63.960  55.301  1.00 54.20           C  
ATOM    103  O   ARG A 297     -19.536  64.638  56.323  1.00 54.13           O  
ATOM    104  CB  ARG A 297     -21.564  62.428  55.028  1.00 54.25           C  
ATOM    105  CG  ARG A 297     -22.998  62.572  55.523  1.00 56.14           C  
ATOM    106  CD  ARG A 297     -23.583  61.242  55.946  1.00 58.87           C  
ATOM    107  NE  ARG A 297     -24.325  60.574  54.860  1.00 61.42           N  
ATOM    108  CZ  ARG A 297     -23.939  59.466  54.212  1.00 62.14           C  
ATOM    109  NH1 ARG A 297     -22.785  58.847  54.503  1.00 62.48           N  
ATOM    110  NH2 ARG A 297     -24.724  58.963  53.261  1.00 61.89           N  
ATOM    111  N   GLU A 298     -18.543  63.380  54.743  1.00 54.83           N  
ATOM    112  CA  GLU A 298     -17.202  63.508  55.324  1.00 55.54           C  
ATOM    113  C   GLU A 298     -16.626  64.911  55.243  1.00 55.32           C  
ATOM    114  O   GLU A 298     -16.094  65.416  56.232  1.00 55.74           O  
ATOM    115  CB  GLU A 298     -16.221  62.554  54.643  1.00 56.08           C  
ATOM    116  CG  GLU A 298     -16.262  61.137  55.191  1.00 58.61           C  
ATOM    117  CD  GLU A 298     -15.856  60.110  54.157  1.00 62.93           C  
ATOM    118  OE1 GLU A 298     -15.229  60.489  53.126  1.00 65.87           O  
ATOM    119  OE2 GLU A 298     -16.181  58.918  54.371  1.00 65.19           O  
ATOM    120  N   ILE A 299     -16.727  65.532  54.067  1.00 55.08           N  
ATOM    121  CA  ILE A 299     -15.974  66.758  53.765  1.00 54.59           C  
ATOM    122  C   ILE A 299     -16.709  68.011  54.203  1.00 54.63           C  
ATOM    123  O   ILE A 299     -16.079  69.018  54.485  1.00 54.96           O  
ATOM    124  CB  ILE A 299     -15.617  66.865  52.258  1.00 54.41           C  
ATOM    125  CG1 ILE A 299     -14.819  65.626  51.820  1.00 53.92           C  
ATOM    126  CG2 ILE A 299     -14.828  68.158  51.982  1.00 53.59           C  
ATOM    127  CD1 ILE A 299     -14.654  65.448  50.331  1.00 53.46           C  
ATOM    128  N   PHE A 300     -18.031  67.955  54.270  1.00 54.77           N  
ATOM    129  CA  PHE A 300     -18.812  69.100  54.726  1.00 55.01           C  
ATOM    130  C   PHE A 300     -19.408  68.899  56.140  1.00 55.39           C  
ATOM    131  O   PHE A 300     -20.509  68.335  56.323  1.00 55.73           O  
ATOM    132  CB  PHE A 300     -19.914  69.402  53.709  1.00 55.15           C  
ATOM    133  CG  PHE A 300     -19.398  69.780  52.347  1.00 54.57           C  
ATOM    134  CD1 PHE A 300     -18.738  70.984  52.146  1.00 54.07           C  
ATOM    135  CD2 PHE A 300     -19.587  68.941  51.269  1.00 54.38           C  
ATOM    136  CE1 PHE A 300     -18.267  71.340  50.890  1.00 54.17           C  
ATOM    137  CE2 PHE A 300     -19.119  69.289  50.008  1.00 54.86           C  
ATOM    138  CZ  PHE A 300     -18.456  70.494  49.819  1.00 54.27           C  
ATOM    139  N   VAL A 432     -17.100  94.940  62.608  1.00 69.37           N  
ATOM    140  CA  VAL A 432     -16.841  96.363  62.379  1.00 69.18           C  
ATOM    141  C   VAL A 432     -16.220  96.483  60.972  1.00 69.05           C  
ATOM    142  O   VAL A 432     -16.897  96.870  60.004  1.00 69.46           O  
ATOM    143  CB  VAL A 432     -15.938  96.964  63.511  1.00 69.24           C  
ATOM    144  CG1 VAL A 432     -16.383  98.387  63.853  1.00 69.27           C  
ATOM    145  CG2 VAL A 432     -15.964  96.061  64.756  1.00 68.69           C  
ATOM    146  N   GLN A 433     -14.926  96.183  60.883  1.00 68.53           N  
ATOM    147  CA  GLN A 433     -14.313  95.622  59.686  1.00 67.88           C  
ATOM    148  C   GLN A 433     -13.743  94.261  60.057  1.00 67.36           C  
ATOM    149  O   GLN A 433     -13.195  93.551  59.205  1.00 67.60           O  
ATOM    150  CB  GLN A 433     -13.176  96.505  59.181  1.00 67.94           C  
ATOM    151  CG  GLN A 433     -11.862  96.395  59.981  1.00 68.11           C  
ATOM    152  CD  GLN A 433     -10.621  96.623  59.127  1.00 68.66           C  
ATOM    153  OE1 GLN A 433     -10.696  96.644  57.893  1.00 69.59           O  
ATOM    154  NE2 GLN A 433      -9.468  96.786  59.781  1.00 68.21           N  
ATOM    155  N   GLU A 434     -13.819  93.933  61.346  1.00 66.39           N  
ATOM    156  CA  GLU A 434     -13.427  92.635  61.835  1.00 65.54           C  
ATOM    157  C   GLU A 434     -14.410  91.615  61.273  1.00 64.71           C  
ATOM    158  O   GLU A 434     -14.020  90.489  60.982  1.00 64.86           O  
ATOM    159  CB  GLU A 434     -13.412  92.617  63.371  1.00 65.45           C  
ATOM    160  N   ILE A 435     -15.669  92.013  61.093  1.00 63.70           N  
ATOM    161  CA  ILE A 435     -16.676  91.131  60.484  1.00 63.18           C  
ATOM    162  C   ILE A 435     -16.349  90.803  59.011  1.00 62.63           C  
ATOM    163  O   ILE A 435     -16.566  89.672  58.544  1.00 62.56           O  
ATOM    164  CB  ILE A 435     -18.106  91.739  60.550  1.00 63.24           C  
ATOM    165  CG1 ILE A 435     -18.550  91.959  62.002  1.00 62.94           C  
ATOM    166  N   TRP A 436     -15.827  91.797  58.292  1.00 61.75           N  
ATOM    167  CA  TRP A 436     -15.481  91.651  56.879  1.00 61.07           C  
ATOM    168  C   TRP A 436     -14.250  90.765  56.691  1.00 60.90           C  
ATOM    169  O   TRP A 436     -14.225  89.894  55.818  1.00 60.86           O  
ATOM    170  CB  TRP A 436     -15.246  93.028  56.245  1.00 60.90           C  
ATOM    171  CG  TRP A 436     -15.098  92.997  54.762  1.00 59.92           C  
ATOM    172  CD1 TRP A 436     -15.531  92.023  53.920  1.00 59.42           C  
ATOM    173  CD2 TRP A 436     -14.517  94.007  53.938  1.00 59.24           C  
ATOM    174  NE1 TRP A 436     -15.238  92.347  52.628  1.00 59.19           N  
ATOM    175  CE2 TRP A 436     -14.614  93.561  52.604  1.00 58.87           C  
ATOM    176  CE3 TRP A 436     -13.914  95.240  54.194  1.00 59.42           C  
ATOM    177  CZ2 TRP A 436     -14.120  94.297  51.524  1.00 58.45           C  
ATOM    178  CZ3 TRP A 436     -13.427  95.978  53.116  1.00 59.32           C  
ATOM    179  CH2 TRP A 436     -13.533  95.498  51.798  1.00 58.96           C  
ATOM    180  N   GLU A 437     -13.232  90.999  57.512  1.00 60.47           N  
ATOM    181  CA  GLU A 437     -12.065  90.132  57.544  1.00 60.18           C  
ATOM    182  C   GLU A 437     -12.465  88.687  57.880  1.00 59.53           C  
ATOM    183  O   GLU A 437     -11.917  87.752  57.301  1.00 59.65           O  
ATOM    184  CB  GLU A 437     -11.025  90.662  58.546  1.00 60.45           C  
ATOM    185  CG  GLU A 437     -10.348  92.003  58.139  1.00 61.67           C  
ATOM    186  CD  GLU A 437      -9.356  92.557  59.190  1.00 63.30           C  
ATOM    187  OE1 GLU A 437      -9.395  92.136  60.378  1.00 63.73           O  
ATOM    188  OE2 GLU A 437      -8.529  93.427  58.815  1.00 63.92           O  
ATOM    189  N   ASP A 438     -13.432  88.515  58.788  1.00 58.94           N  
ATOM    190  CA  ASP A 438     -13.844  87.186  59.286  1.00 58.24           C  
ATOM    191  C   ASP A 438     -14.609  86.388  58.232  1.00 57.66           C  
ATOM    192  O   ASP A 438     -14.346  85.198  58.007  1.00 57.27           O  
ATOM    193  N   PHE A 439     -15.565  87.063  57.602  1.00 56.99           N  
ATOM    194  CA  PHE A 439     -16.216  86.571  56.398  1.00 56.56           C  
ATOM    195  C   PHE A 439     -15.194  86.261  55.292  1.00 55.80           C  
ATOM    196  O   PHE A 439     -15.248  85.204  54.663  1.00 55.54           O  
ATOM    197  CB  PHE A 439     -17.193  87.635  55.912  1.00 56.81           C  
ATOM    198  CG  PHE A 439     -17.967  87.247  54.690  1.00 58.04           C  
ATOM    199  CD1 PHE A 439     -18.900  86.221  54.744  1.00 59.31           C  
ATOM    200  CD2 PHE A 439     -17.791  87.931  53.489  1.00 59.47           C  
ATOM    201  CE1 PHE A 439     -19.641  85.864  53.611  1.00 60.19           C  
ATOM    202  CE2 PHE A 439     -18.527  87.585  52.349  1.00 60.18           C  
ATOM    203  CZ  PHE A 439     -19.452  86.551  52.412  1.00 60.31           C  
ATOM    204  N   SER A 440     -14.248  87.171  55.078  1.00 55.04           N  
ATOM    205  CA  SER A 440     -13.297  87.029  53.981  1.00 54.35           C  
ATOM    206  C   SER A 440     -12.491  85.743  54.088  1.00 54.44           C  
ATOM    207  O   SER A 440     -12.294  85.058  53.093  1.00 54.69           O  
ATOM    208  CB  SER A 440     -12.371  88.234  53.902  1.00 53.91           C  
ATOM    209  OG  SER A 440     -13.107  89.387  53.552  1.00 52.37           O  
ATOM    210  N   MET A 441     -12.049  85.400  55.290  1.00 54.22           N  
ATOM    211  CA  MET A 441     -11.238  84.188  55.493  1.00 54.30           C  
ATOM    212  C   MET A 441     -12.032  82.899  55.678  1.00 53.28           C  
ATOM    213  O   MET A 441     -11.448  81.821  55.778  1.00 52.86           O  
ATOM    214  CB  MET A 441     -10.356  84.356  56.716  1.00 55.12           C  
ATOM    215  CG  MET A 441      -9.048  85.053  56.451  1.00 57.41           C  
ATOM    216  SD  MET A 441      -8.168  85.046  58.012  1.00 63.62           S  
ATOM    217  CE  MET A 441      -9.353  85.909  59.080  1.00 61.74           C  
ATOM    218  N   SER A 442     -13.349  83.017  55.772  1.00 52.55           N  
ATOM    219  CA  SER A 442     -14.226  81.856  55.739  1.00 51.98           C  
ATOM    220  C   SER A 442     -14.053  81.076  54.419  1.00 51.41           C  
ATOM    221  O   SER A 442     -14.045  79.841  54.409  1.00 51.65           O  
ATOM    222  CB  SER A 442     -15.682  82.303  55.897  1.00 51.77           C  
ATOM    223  N   PHE A 443     -13.889  81.813  53.318  1.00 50.53           N  
ATOM    224  CA  PHE A 443     -13.889  81.245  51.959  1.00 49.72           C  
ATOM    225  C   PHE A 443     -12.737  80.288  51.643  1.00 48.59           C  
ATOM    226  O   PHE A 443     -12.906  79.367  50.849  1.00 48.47           O  
ATOM    227  CB  PHE A 443     -13.917  82.374  50.906  1.00 49.89           C  
ATOM    228  CG  PHE A 443     -15.225  83.120  50.852  1.00 50.62           C  
ATOM    229  CD1 PHE A 443     -16.303  82.599  50.145  1.00 51.71           C  
ATOM    230  CD2 PHE A 443     -15.377  84.340  51.505  1.00 51.29           C  
ATOM    231  CE1 PHE A 443     -17.518  83.279  50.097  1.00 52.32           C  
ATOM    232  CE2 PHE A 443     -16.582  85.033  51.460  1.00 51.43           C  
ATOM    233  CZ  PHE A 443     -17.657  84.498  50.756  1.00 52.30           C  
ATOM    234  N   THR A 444     -11.574  80.510  52.247  1.00 47.39           N  
ATOM    235  CA  THR A 444     -10.382  79.720  51.910  1.00 46.45           C  
ATOM    236  C   THR A 444     -10.527  78.239  52.281  1.00 45.64           C  
ATOM    237  O   THR A 444     -10.302  77.380  51.443  1.00 45.42           O  
ATOM    238  CB  THR A 444      -9.091  80.324  52.521  1.00 46.28           C  
ATOM    239  OG1 THR A 444      -8.915  81.674  52.055  1.00 46.88           O  
ATOM    240  CG2 THR A 444      -7.894  79.497  52.138  1.00 45.39           C  
ATOM    241  N   PRO A 445     -10.906  77.938  53.535  1.00 44.88           N  
ATOM    242  CA  PRO A 445     -11.178  76.521  53.839  1.00 44.18           C  
ATOM    243  C   PRO A 445     -12.402  75.973  53.088  1.00 43.39           C  
ATOM    244  O   PRO A 445     -12.419  74.806  52.701  1.00 43.30           O  
ATOM    245  CB  PRO A 445     -11.410  76.516  55.365  1.00 44.20           C  
ATOM    246  CG  PRO A 445     -11.701  77.963  55.733  1.00 44.30           C  
ATOM    247  CD  PRO A 445     -10.968  78.797  54.738  1.00 44.58           C  
ATOM    248  N   ALA A 446     -13.410  76.811  52.877  1.00 42.54           N  
ATOM    249  CA  ALA A 446     -14.596  76.393  52.129  1.00 42.10           C  
ATOM    250  C   ALA A 446     -14.231  75.997  50.704  1.00 41.59           C  
ATOM    251  O   ALA A 446     -14.631  74.945  50.234  1.00 41.82           O  
ATOM    252  CB  ALA A 446     -15.639  77.492  52.126  1.00 41.83           C  
ATOM    253  N   VAL A 447     -13.449  76.828  50.028  1.00 41.38           N  
ATOM    254  CA  VAL A 447     -13.010  76.517  48.670  1.00 41.30           C  
ATOM    255  C   VAL A 447     -12.201  75.207  48.657  1.00 41.83           C  
ATOM    256  O   VAL A 447     -12.371  74.385  47.757  1.00 41.89           O  
ATOM    257  CB  VAL A 447     -12.210  77.689  48.024  1.00 41.18           C  
ATOM    258  CG1 VAL A 447     -11.749  77.319  46.626  1.00 41.03           C  
ATOM    259  CG2 VAL A 447     -13.060  78.950  47.960  1.00 39.59           C  
ATOM    260  N   ARG A 448     -11.357  74.995  49.668  1.00 42.05           N  
ATOM    261  CA  ARG A 448     -10.594  73.748  49.764  1.00 42.39           C  
ATOM    262  C   ARG A 448     -11.480  72.558  50.025  1.00 42.20           C  
ATOM    263  O   ARG A 448     -11.165  71.471  49.574  1.00 42.35           O  
ATOM    264  CB  ARG A 448      -9.528  73.811  50.855  1.00 42.75           C  
ATOM    265  CG  ARG A 448      -8.391  74.755  50.534  1.00 44.83           C  
ATOM    266  CD  ARG A 448      -7.201  74.491  51.411  1.00 48.73           C  
ATOM    267  NE  ARG A 448      -6.200  75.557  51.295  1.00 52.51           N  
ATOM    268  CZ  ARG A 448      -6.050  76.578  52.144  1.00 56.02           C  
ATOM    269  NH1 ARG A 448      -6.837  76.715  53.224  1.00 57.88           N  
ATOM    270  NH2 ARG A 448      -5.095  77.479  51.913  1.00 56.73           N  
ATOM    271  N   GLU A 449     -12.575  72.752  50.759  1.00 42.31           N  
ATOM    272  CA  GLU A 449     -13.555  71.673  50.979  1.00 42.30           C  
ATOM    273  C   GLU A 449     -14.208  71.291  49.665  1.00 41.71           C  
ATOM    274  O   GLU A 449     -14.391  70.115  49.382  1.00 41.63           O  
ATOM    275  CB  GLU A 449     -14.650  72.084  51.972  1.00 42.56           C  
ATOM    276  CG  GLU A 449     -14.157  72.226  53.397  1.00 44.76           C  
ATOM    277  CD  GLU A 449     -15.192  72.776  54.361  1.00 47.26           C  
ATOM    278  OE1 GLU A 449     -16.233  73.339  53.932  1.00 48.69           O  
ATOM    279  OE2 GLU A 449     -14.942  72.642  55.577  1.00 49.49           O  
ATOM    280  N   VAL A 450     -14.558  72.293  48.870  1.00 40.95           N  
ATOM    281  CA  VAL A 450     -15.151  72.046  47.570  1.00 40.61           C  
ATOM    282  C   VAL A 450     -14.166  71.310  46.655  1.00 40.62           C  
ATOM    283  O   VAL A 450     -14.548  70.362  45.973  1.00 40.70           O  
ATOM    284  CB  VAL A 450     -15.645  73.365  46.898  1.00 40.67           C  
ATOM    285  CG1 VAL A 450     -16.144  73.082  45.493  1.00 39.08           C  
ATOM    286  CG2 VAL A 450     -16.738  74.027  47.756  1.00 38.95           C  
ATOM    287  N   VAL A 451     -12.903  71.723  46.655  1.00 40.55           N  
ATOM    288  CA  VAL A 451     -11.904  71.060  45.830  1.00 40.66           C  
ATOM    289  C   VAL A 451     -11.754  69.580  46.222  1.00 41.24           C  
ATOM    290  O   VAL A 451     -11.675  68.726  45.356  1.00 41.58           O  
ATOM    291  CB  VAL A 451     -10.531  71.782  45.877  1.00 40.69           C  
ATOM    292  CG1 VAL A 451      -9.489  71.012  45.076  1.00 40.04           C  
ATOM    293  CG2 VAL A 451     -10.647  73.204  45.343  1.00 39.28           C  
ATOM    294  N   GLU A 452     -11.742  69.274  47.513  1.00 41.63           N  
ATOM    295  CA  GLU A 452     -11.625  67.884  47.972  1.00 42.28           C  
ATOM    296  C   GLU A 452     -12.869  67.049  47.604  1.00 41.83           C  
ATOM    297  O   GLU A 452     -12.762  65.917  47.144  1.00 42.24           O  
ATOM    298  CB  GLU A 452     -11.376  67.857  49.494  1.00 42.89           C  
ATOM    299  CG  GLU A 452     -10.997  66.480  50.101  1.00 45.65           C  
ATOM    300  CD  GLU A 452      -9.620  65.976  49.646  1.00 50.40           C  
ATOM    301  OE1 GLU A 452      -8.776  66.821  49.252  1.00 53.80           O  
ATOM    302  OE2 GLU A 452      -9.378  64.739  49.673  1.00 53.08           O  
ATOM    303  N   PHE A 453     -14.050  67.609  47.821  1.00 41.35           N  
ATOM    304  CA  PHE A 453     -15.302  66.988  47.390  1.00 40.69           C  
ATOM    305  C   PHE A 453     -15.194  66.634  45.916  1.00 40.60           C  
ATOM    306  O   PHE A 453     -15.350  65.481  45.559  1.00 40.45           O  
ATOM    307  CB  PHE A 453     -16.472  67.941  47.677  1.00 40.44           C  
ATOM    308  CG  PHE A 453     -17.839  67.439  47.233  1.00 40.29           C  
ATOM    309  CD1 PHE A 453     -18.411  66.315  47.807  1.00 39.68           C  
ATOM    310  CD2 PHE A 453     -18.581  68.152  46.283  1.00 39.32           C  
ATOM    311  CE1 PHE A 453     -19.662  65.890  47.423  1.00 39.27           C  
ATOM    312  CE2 PHE A 453     -19.830  67.730  45.894  1.00 38.83           C  
ATOM    313  CZ  PHE A 453     -20.374  66.599  46.468  1.00 39.82           C  
ATOM    314  N   ALA A 454     -14.872  67.604  45.065  1.00 40.76           N  
ATOM    315  CA  ALA A 454     -14.784  67.343  43.619  1.00 40.93           C  
ATOM    316  C   ALA A 454     -13.932  66.106  43.319  1.00 41.21           C  
ATOM    317  O   ALA A 454     -14.283  65.290  42.462  1.00 40.85           O  
ATOM    318  CB  ALA A 454     -14.246  68.553  42.864  1.00 40.66           C  
ATOM    319  N   LYS A 455     -12.832  65.949  44.046  1.00 41.76           N  
ATOM    320  CA  LYS A 455     -11.921  64.833  43.806  1.00 42.39           C  
ATOM    321  C   LYS A 455     -12.588  63.490  44.084  1.00 42.80           C  
ATOM    322  O   LYS A 455     -12.154  62.478  43.544  1.00 43.09           O  
ATOM    323  CB  LYS A 455     -10.655  64.962  44.663  1.00 42.59           C  
ATOM    324  CG  LYS A 455      -9.774  66.165  44.338  1.00 43.00           C  
ATOM    325  CD  LYS A 455      -8.588  66.236  45.298  1.00 44.07           C  
ATOM    326  CE  LYS A 455      -7.571  67.302  44.895  1.00 44.17           C  
ATOM    327  NZ  LYS A 455      -6.493  67.367  45.919  1.00 44.59           N  
ATOM    328  N   HIS A 456     -13.630  63.484  44.921  1.00 43.10           N  
ATOM    329  CA  HIS A 456     -14.375  62.261  45.245  1.00 43.61           C  
ATOM    330  C   HIS A 456     -15.567  61.965  44.327  1.00 43.42           C  
ATOM    331  O   HIS A 456     -16.220  60.920  44.461  1.00 43.33           O  
ATOM    332  CB  HIS A 456     -14.849  62.312  46.692  1.00 44.00           C  
ATOM    333  CG  HIS A 456     -13.746  62.123  47.681  1.00 46.78           C  
ATOM    334  ND1 HIS A 456     -12.867  63.131  48.016  1.00 49.61           N  
ATOM    335  CD2 HIS A 456     -13.362  61.033  48.389  1.00 48.92           C  
ATOM    336  CE1 HIS A 456     -11.995  62.673  48.900  1.00 50.67           C  
ATOM    337  NE2 HIS A 456     -12.275  61.404  49.146  1.00 50.07           N  
ATOM    338  N   ILE A 457     -15.839  62.877  43.400  1.00 43.16           N  
ATOM    339  CA  ILE A 457     -16.930  62.721  42.459  1.00 43.02           C  
ATOM    340  C   ILE A 457     -16.468  61.723  41.394  1.00 43.48           C  
ATOM    341  O   ILE A 457     -15.461  61.971  40.701  1.00 43.47           O  
ATOM    342  CB  ILE A 457     -17.335  64.084  41.815  1.00 42.90           C  
ATOM    343  CG1 ILE A 457     -17.719  65.095  42.908  1.00 42.43           C  
ATOM    344  CG2 ILE A 457     -18.492  63.899  40.829  1.00 42.61           C  
ATOM    345  CD1 ILE A 457     -18.106  66.479  42.409  1.00 41.48           C  
ATOM    346  N   PRO A 458     -17.183  60.581  41.274  1.00 43.74           N  
ATOM    347  CA  PRO A 458     -16.830  59.552  40.296  1.00 43.61           C  
ATOM    348  C   PRO A 458     -16.647  60.142  38.913  1.00 43.92           C  
ATOM    349  O   PRO A 458     -17.607  60.645  38.335  1.00 44.02           O  
ATOM    350  CB  PRO A 458     -18.046  58.619  40.306  1.00 43.62           C  
ATOM    351  CG  PRO A 458     -18.695  58.841  41.612  1.00 43.85           C  
ATOM    352  CD  PRO A 458     -18.442  60.262  41.978  1.00 43.83           C  
ATOM    353  N   GLY A 459     -15.419  60.109  38.407  1.00 44.29           N  
ATOM    354  CA  GLY A 459     -15.121  60.585  37.065  1.00 44.89           C  
ATOM    355  C   GLY A 459     -14.535  61.980  36.971  1.00 45.62           C  
ATOM    356  O   GLY A 459     -14.036  62.370  35.917  1.00 45.62           O  
ATOM    357  N   PHE A 460     -14.590  62.748  38.055  1.00 46.72           N  
ATOM    358  CA  PHE A 460     -14.028  64.090  38.020  1.00 47.53           C  
ATOM    359  C   PHE A 460     -12.533  64.050  37.729  1.00 48.18           C  
ATOM    360  O   PHE A 460     -12.036  64.818  36.889  1.00 48.23           O  
ATOM    361  CB  PHE A 460     -14.280  64.844  39.319  1.00 47.49           C  
ATOM    362  CG  PHE A 460     -13.832  66.286  39.272  1.00 48.52           C  
ATOM    363  CD1 PHE A 460     -14.630  67.260  38.679  1.00 49.54           C  
ATOM    364  CD2 PHE A 460     -12.617  66.670  39.809  1.00 49.55           C  
ATOM    365  CE1 PHE A 460     -14.224  68.589  38.626  1.00 49.50           C  
ATOM    366  CE2 PHE A 460     -12.214  67.991  39.768  1.00 50.37           C  
ATOM    367  CZ  PHE A 460     -13.022  68.953  39.167  1.00 50.16           C  
ATOM    368  N   ARG A 461     -11.819  63.147  38.400  1.00 48.99           N  
ATOM    369  CA  ARG A 461     -10.361  63.096  38.248  1.00 49.92           C  
ATOM    370  C   ARG A 461      -9.885  62.316  37.025  1.00 50.12           C  
ATOM    371  O   ARG A 461      -8.689  62.129  36.853  1.00 50.59           O  
ATOM    372  CB  ARG A 461      -9.680  62.602  39.525  1.00 49.94           C  
ATOM    373  CG  ARG A 461     -10.062  63.446  40.742  1.00 51.10           C  
ATOM    374  CD  ARG A 461      -8.855  63.875  41.565  1.00 51.71           C  
ATOM    375  NE  ARG A 461      -8.126  64.978  40.949  1.00 52.15           N  
ATOM    376  CZ  ARG A 461      -6.914  65.389  41.302  1.00 51.25           C  
ATOM    377  NH1 ARG A 461      -6.256  64.810  42.300  1.00 51.23           N  
ATOM    378  NH2 ARG A 461      -6.360  66.398  40.644  1.00 51.68           N  
ATOM    379  N   ASP A 462     -10.813  61.882  36.173  1.00 50.52           N  
ATOM    380  CA  ASP A 462     -10.470  61.427  34.816  1.00 50.63           C  
ATOM    381  C   ASP A 462     -10.526  62.554  33.795  1.00 50.35           C  
ATOM    382  O   ASP A 462     -10.040  62.391  32.688  1.00 49.98           O  
ATOM    383  CB  ASP A 462     -11.397  60.309  34.353  1.00 50.82           C  
ATOM    384  CG  ASP A 462     -11.398  59.118  35.293  1.00 52.11           C  
ATOM    385  OD1 ASP A 462     -10.365  58.863  35.958  1.00 53.57           O  
ATOM    386  OD2 ASP A 462     -12.450  58.440  35.362  1.00 53.98           O  
ATOM    387  N   LEU A 463     -11.148  63.676  34.149  1.00 50.40           N  
ATOM    388  CA  LEU A 463     -11.068  64.868  33.318  1.00 50.38           C  
ATOM    389  C   LEU A 463      -9.621  65.355  33.383  1.00 50.64           C  
ATOM    390  O   LEU A 463      -8.913  65.076  34.369  1.00 51.18           O  
ATOM    391  CB  LEU A 463     -12.005  65.977  33.823  1.00 50.40           C  
ATOM    392  CG  LEU A 463     -13.510  65.713  33.969  1.00 50.26           C  
ATOM    393  CD1 LEU A 463     -14.218  66.959  34.474  1.00 48.80           C  
ATOM    394  CD2 LEU A 463     -14.130  65.254  32.668  1.00 49.57           C  
ATOM    395  N   SER A 464      -9.183  66.080  32.351  1.00 50.36           N  
ATOM    396  CA  SER A 464      -7.831  66.630  32.320  1.00 50.09           C  
ATOM    397  C   SER A 464      -7.657  67.624  33.455  1.00 50.50           C  
ATOM    398  O   SER A 464      -8.639  68.162  33.973  1.00 50.30           O  
ATOM    399  CB  SER A 464      -7.544  67.306  30.974  1.00 49.94           C  
ATOM    400  OG  SER A 464      -8.394  68.413  30.739  1.00 49.41           O  
ATOM    401  N   GLN A 465      -6.411  67.864  33.848  1.00 51.03           N  
ATOM    402  CA  GLN A 465      -6.120  68.846  34.901  1.00 51.62           C  
ATOM    403  C   GLN A 465      -6.730  70.208  34.573  1.00 51.15           C  
ATOM    404  O   GLN A 465      -7.335  70.857  35.441  1.00 51.32           O  
ATOM    405  CB  GLN A 465      -4.610  68.989  35.111  1.00 52.20           C  
ATOM    406  CG  GLN A 465      -4.029  67.978  36.096  1.00 54.56           C  
ATOM    407  CD  GLN A 465      -4.012  68.499  37.524  1.00 57.60           C  
ATOM    408  OE1 GLN A 465      -4.607  67.898  38.431  1.00 59.69           O  
ATOM    409  NE2 GLN A 465      -3.327  69.627  37.733  1.00 58.35           N  
ATOM    410  N   HIS A 466      -6.564  70.621  33.316  1.00 50.43           N  
ATOM    411  CA  HIS A 466      -7.099  71.885  32.819  1.00 49.88           C  
ATOM    412  C   HIS A 466      -8.619  71.962  32.975  1.00 48.71           C  
ATOM    413  O   HIS A 466      -9.138  72.973  33.427  1.00 48.80           O  
ATOM    414  CB  HIS A 466      -6.705  72.080  31.351  1.00 50.06           C  
ATOM    415  CG  HIS A 466      -7.304  73.294  30.711  1.00 52.10           C  
ATOM    416  ND1 HIS A 466      -6.619  74.484  30.582  1.00 54.75           N  
ATOM    417  CD2 HIS A 466      -8.524  73.500  30.152  1.00 54.09           C  
ATOM    418  CE1 HIS A 466      -7.390  75.370  29.972  1.00 55.44           C  
ATOM    419  NE2 HIS A 466      -8.552  74.798  29.702  1.00 55.06           N  
ATOM    420  N   ASP A 467      -9.322  70.897  32.597  1.00 47.55           N  
ATOM    421  CA  ASP A 467     -10.787  70.861  32.658  1.00 46.53           C  
ATOM    422  C   ASP A 467     -11.275  70.843  34.116  1.00 45.43           C  
ATOM    423  O   ASP A 467     -12.131  71.628  34.480  1.00 45.37           O  
ATOM    424  CB  ASP A 467     -11.331  69.663  31.858  1.00 46.69           C  
ATOM    425  CG  ASP A 467     -11.210  69.857  30.334  1.00 47.23           C  
ATOM    426  OD1 ASP A 467     -10.607  70.855  29.894  1.00 48.42           O  
ATOM    427  OD2 ASP A 467     -11.725  69.018  29.563  1.00 47.63           O  
ATOM    428  N   GLN A 468     -10.706  69.969  34.941  1.00 44.36           N  
ATOM    429  CA  GLN A 468     -10.911  69.996  36.393  1.00 43.75           C  
ATOM    430  C   GLN A 468     -10.806  71.418  36.963  1.00 43.45           C  
ATOM    431  O   GLN A 468     -11.728  71.924  37.616  1.00 43.36           O  
ATOM    432  CB  GLN A 468      -9.864  69.116  37.100  1.00 43.58           C  
ATOM    433  CG  GLN A 468     -10.041  67.600  36.902  1.00 43.33           C  
ATOM    434  CD  GLN A 468      -8.967  66.758  37.607  1.00 41.03           C  
ATOM    435  OE1 GLN A 468      -8.493  67.114  38.684  1.00 39.39           O  
ATOM    436  NE2 GLN A 468      -8.600  65.632  36.999  1.00 38.85           N  
ATOM    437  N   VAL A 469      -9.662  72.049  36.719  1.00 43.08           N  
ATOM    438  CA  VAL A 469      -9.384  73.375  37.259  1.00 42.67           C  
ATOM    439  C   VAL A 469     -10.369  74.392  36.696  1.00 42.29           C  
ATOM    440  O   VAL A 469     -10.839  75.267  37.421  1.00 42.63           O  
ATOM    441  CB  VAL A 469      -7.928  73.832  36.951  1.00 42.82           C  
ATOM    442  CG1 VAL A 469      -7.729  75.257  37.410  1.00 43.07           C  
ATOM    443  CG2 VAL A 469      -6.905  72.921  37.638  1.00 42.17           C  
ATOM    444  N   THR A 470     -10.689  74.259  35.408  1.00 41.54           N  
ATOM    445  CA  THR A 470     -11.626  75.159  34.741  1.00 40.81           C  
ATOM    446  C   THR A 470     -13.021  75.060  35.362  1.00 40.41           C  
ATOM    447  O   THR A 470     -13.688  76.086  35.547  1.00 40.73           O  
ATOM    448  CB  THR A 470     -11.668  74.920  33.194  1.00 40.78           C  
ATOM    449  OG1 THR A 470     -10.409  75.286  32.609  1.00 40.30           O  
ATOM    450  CG2 THR A 470     -12.744  75.756  32.540  1.00 40.86           C  
ATOM    451  N   LEU A 471     -13.450  73.848  35.713  1.00 39.61           N  
ATOM    452  CA  LEU A 471     -14.773  73.660  36.326  1.00 39.20           C  
ATOM    453  C   LEU A 471     -14.857  74.246  37.729  1.00 38.84           C  
ATOM    454  O   LEU A 471     -15.886  74.811  38.099  1.00 38.81           O  
ATOM    455  CB  LEU A 471     -15.158  72.183  36.414  1.00 39.13           C  
ATOM    456  CG  LEU A 471     -15.882  71.552  35.242  1.00 39.51           C  
ATOM    457  CD1 LEU A 471     -16.143  70.085  35.575  1.00 39.75           C  
ATOM    458  CD2 LEU A 471     -17.185  72.283  34.905  1.00 40.28           C  
ATOM    459  N   LEU A 472     -13.794  74.077  38.521  1.00 38.36           N  
ATOM    460  CA  LEU A 472     -13.785  74.584  39.904  1.00 37.64           C  
ATOM    461  C   LEU A 472     -13.809  76.103  39.924  1.00 37.46           C  
ATOM    462  O   LEU A 472     -14.526  76.713  40.734  1.00 36.73           O  
ATOM    463  CB  LEU A 472     -12.594  74.032  40.684  1.00 37.32           C  
ATOM    464  CG  LEU A 472     -12.839  72.560  41.062  1.00 37.73           C  
ATOM    465  CD1 LEU A 472     -11.544  71.773  41.198  1.00 35.82           C  
ATOM    466  CD2 LEU A 472     -13.715  72.439  42.329  1.00 36.27           C  
ATOM    467  N   LYS A 473     -13.049  76.710  39.011  1.00 37.23           N  
ATOM    468  CA  LYS A 473     -13.052  78.155  38.865  1.00 37.29           C  
ATOM    469  C   LYS A 473     -14.430  78.644  38.460  1.00 36.81           C  
ATOM    470  O   LYS A 473     -14.957  79.593  39.027  1.00 36.34           O  
ATOM    471  CB  LYS A 473     -12.034  78.580  37.824  1.00 37.71           C  
ATOM    472  CG  LYS A 473     -10.581  78.512  38.289  1.00 39.71           C  
ATOM    473  CD  LYS A 473      -9.701  79.254  37.286  1.00 42.34           C  
ATOM    474  CE  LYS A 473      -8.292  78.702  37.219  1.00 44.03           C  
ATOM    475  NZ  LYS A 473      -7.605  78.821  38.523  1.00 45.39           N  
ATOM    476  N   ALA A 474     -15.021  77.971  37.483  1.00 36.84           N  
ATOM    477  CA  ALA A 474     -16.335  78.363  36.975  1.00 36.79           C  
ATOM    478  C   ALA A 474     -17.446  78.079  37.990  1.00 36.73           C  
ATOM    479  O   ALA A 474     -18.303  78.920  38.210  1.00 36.93           O  
ATOM    480  CB  ALA A 474     -16.618  77.662  35.658  1.00 36.51           C  
ATOM    481  N   GLY A 475     -17.392  76.917  38.646  1.00 36.82           N  
ATOM    482  CA  GLY A 475     -18.506  76.411  39.451  1.00 36.52           C  
ATOM    483  C   GLY A 475     -18.424  76.472  40.960  1.00 36.53           C  
ATOM    484  O   GLY A 475     -19.423  76.191  41.614  1.00 37.03           O  
ATOM    485  N   THR A 476     -17.270  76.826  41.531  1.00 36.53           N  
ATOM    486  CA  THR A 476     -17.108  76.826  42.999  1.00 36.59           C  
ATOM    487  C   THR A 476     -17.989  77.859  43.748  1.00 37.02           C  
ATOM    488  O   THR A 476     -18.522  77.545  44.814  1.00 37.26           O  
ATOM    489  CB  THR A 476     -15.609  76.987  43.435  1.00 36.78           C  
ATOM    490  OG1 THR A 476     -14.838  75.899  42.920  1.00 35.92           O  
ATOM    491  CG2 THR A 476     -15.459  77.016  44.979  1.00 35.65           C  
ATOM    492  N   PHE A 477     -18.143  79.075  43.217  1.00 37.25           N  
ATOM    493  CA  PHE A 477     -19.001  80.078  43.867  1.00 37.48           C  
ATOM    494  C   PHE A 477     -20.429  79.574  44.005  1.00 37.34           C  
ATOM    495  O   PHE A 477     -21.055  79.753  45.032  1.00 37.18           O  
ATOM    496  CB  PHE A 477     -18.996  81.391  43.090  1.00 37.87           C  
ATOM    497  CG  PHE A 477     -19.868  82.466  43.698  1.00 39.99           C  
ATOM    498  CD1 PHE A 477     -19.361  83.340  44.642  1.00 42.64           C  
ATOM    499  CD2 PHE A 477     -21.195  82.603  43.325  1.00 42.21           C  
ATOM    500  CE1 PHE A 477     -20.170  84.337  45.204  1.00 43.50           C  
ATOM    501  CE2 PHE A 477     -22.003  83.595  43.888  1.00 43.29           C  
ATOM    502  CZ  PHE A 477     -21.485  84.460  44.820  1.00 43.00           C  
ATOM    503  N   GLU A 478     -20.937  78.939  42.962  1.00 37.56           N  
ATOM    504  CA  GLU A 478     -22.304  78.431  42.973  1.00 37.83           C  
ATOM    505  C   GLU A 478     -22.467  77.303  43.997  1.00 38.06           C  
ATOM    506  O   GLU A 478     -23.490  77.225  44.678  1.00 37.94           O  
ATOM    507  CB  GLU A 478     -22.709  77.960  41.569  1.00 37.85           C  
ATOM    508  CG  GLU A 478     -22.895  79.092  40.546  1.00 38.69           C  
ATOM    509  CD  GLU A 478     -22.950  78.596  39.100  1.00 41.31           C  
ATOM    510  OE1 GLU A 478     -23.559  77.530  38.842  1.00 43.31           O  
ATOM    511  OE2 GLU A 478     -22.377  79.274  38.214  1.00 42.58           O  
ATOM    512  N   VAL A 479     -21.460  76.434  44.100  1.00 38.17           N  
ATOM    513  CA  VAL A 479     -21.448  75.374  45.111  1.00 38.38           C  
ATOM    514  C   VAL A 479     -21.448  75.982  46.507  1.00 38.81           C  
ATOM    515  O   VAL A 479     -22.176  75.533  47.369  1.00 38.80           O  
ATOM    516  CB  VAL A 479     -20.219  74.441  44.956  1.00 38.45           C  
ATOM    517  CG1 VAL A 479     -20.109  73.470  46.124  1.00 38.09           C  
ATOM    518  CG2 VAL A 479     -20.290  73.695  43.640  1.00 37.70           C  
ATOM    519  N   LEU A 480     -20.643  77.015  46.722  1.00 39.49           N  
ATOM    520  CA  LEU A 480     -20.657  77.726  47.996  1.00 40.15           C  
ATOM    521  C   LEU A 480     -22.042  78.320  48.325  1.00 41.22           C  
ATOM    522  O   LEU A 480     -22.462  78.315  49.472  1.00 41.00           O  
ATOM    523  CB  LEU A 480     -19.573  78.804  48.011  1.00 39.66           C  
ATOM    524  CG  LEU A 480     -18.148  78.246  48.046  1.00 39.38           C  
ATOM    525  CD1 LEU A 480     -17.130  79.364  48.048  1.00 38.29           C  
ATOM    526  CD2 LEU A 480     -17.936  77.321  49.245  1.00 38.01           C  
ATOM    527  N   MET A 481     -22.750  78.819  47.322  1.00 42.82           N  
ATOM    528  CA  MET A 481     -24.116  79.269  47.515  1.00 44.30           C  
ATOM    529  C   MET A 481     -24.999  78.159  48.062  1.00 45.38           C  
ATOM    530  O   MET A 481     -25.900  78.426  48.845  1.00 45.20           O  
ATOM    531  CB  MET A 481     -24.724  79.745  46.195  1.00 44.90           C  
ATOM    532  CG  MET A 481     -24.080  80.966  45.552  1.00 46.75           C  
ATOM    533  SD  MET A 481     -24.050  82.376  46.672  1.00 50.83           S  
ATOM    534  CE  MET A 481     -22.500  82.036  47.550  1.00 50.73           C  
ATOM    535  N   VAL A 482     -24.761  76.922  47.621  1.00 47.22           N  
ATOM    536  CA  VAL A 482     -25.550  75.757  48.062  1.00 48.43           C  
ATOM    537  C   VAL A 482     -25.167  75.352  49.474  1.00 50.08           C  
ATOM    538  O   VAL A 482     -26.026  74.992  50.264  1.00 50.57           O  
ATOM    539  CB  VAL A 482     -25.372  74.514  47.127  1.00 48.33           C  
ATOM    540  CG1 VAL A 482     -26.127  73.305  47.680  1.00 47.54           C  
ATOM    541  CG2 VAL A 482     -25.826  74.821  45.713  1.00 47.38           C  
ATOM    542  N   ARG A 483     -23.873  75.399  49.769  1.00 52.33           N  
ATOM    543  CA  ARG A 483     -23.344  75.082  51.098  1.00 54.36           C  
ATOM    544  C   ARG A 483     -23.793  76.084  52.162  1.00 55.79           C  
ATOM    545  O   ARG A 483     -24.166  75.699  53.258  1.00 55.60           O  
ATOM    546  CB  ARG A 483     -21.810  75.031  51.055  1.00 54.57           C  
ATOM    547  CG  ARG A 483     -21.222  73.767  50.446  1.00 56.41           C  
ATOM    548  CD  ARG A 483     -21.657  72.517  51.216  1.00 60.04           C  
ATOM    549  NE  ARG A 483     -21.573  72.714  52.671  1.00 63.35           N  
ATOM    550  CZ  ARG A 483     -22.392  72.173  53.584  1.00 65.78           C  
ATOM    551  NH1 ARG A 483     -23.395  71.349  53.241  1.00 65.59           N  
ATOM    552  NH2 ARG A 483     -22.196  72.466  54.871  1.00 66.79           N  
ATOM    553  N   PHE A 484     -23.737  77.368  51.836  1.00 58.02           N  
ATOM    554  CA  PHE A 484     -24.238  78.393  52.723  1.00 60.00           C  
ATOM    555  C   PHE A 484     -25.694  78.100  53.010  1.00 61.91           C  
ATOM    556  O   PHE A 484     -26.140  78.177  54.147  1.00 62.03           O  
ATOM    557  CB  PHE A 484     -24.082  79.776  52.088  1.00 60.17           C  
ATOM    558  CG  PHE A 484     -22.643  80.232  51.968  1.00 60.69           C  
ATOM    559  N   ALA A 485     -26.421  77.729  51.963  1.00 64.47           N  
ATOM    560  CA  ALA A 485     -27.843  77.396  52.050  1.00 66.71           C  
ATOM    561  C   ALA A 485     -28.219  76.598  53.291  1.00 69.05           C  
ATOM    562  O   ALA A 485     -29.152  76.962  54.008  1.00 69.66           O  
ATOM    563  N   SER A 486     -27.490  75.513  53.542  1.00 71.10           N  
ATOM    564  CA  SER A 486     -27.723  74.681  54.723  1.00 72.49           C  
ATOM    565  C   SER A 486     -27.253  75.420  55.981  1.00 73.73           C  
ATOM    566  O   SER A 486     -27.963  75.442  56.991  1.00 74.21           O  
ATOM    567  CB  SER A 486     -27.029  73.308  54.582  1.00 72.58           C  
ATOM    568  OG  SER A 486     -25.622  73.393  54.776  1.00 72.76           O  
ATOM    569  N   LEU A 487     -26.078  76.048  55.901  1.00 75.07           N  
ATOM    570  CA  LEU A 487     -25.484  76.784  57.031  1.00 76.17           C  
ATOM    571  C   LEU A 487     -26.138  78.154  57.332  1.00 77.23           C  
ATOM    572  O   LEU A 487     -25.486  79.032  57.909  1.00 77.32           O  
ATOM    573  CB  LEU A 487     -23.981  76.998  56.782  1.00 76.30           C  
ATOM    574  N   PHE A 488     -27.409  78.329  56.950  1.00 78.33           N  
ATOM    575  CA  PHE A 488     -28.152  79.569  57.198  1.00 78.98           C  
ATOM    576  C   PHE A 488     -28.936  79.420  58.504  1.00 79.75           C  
ATOM    577  O   PHE A 488     -28.354  79.037  59.522  1.00 80.09           O  
ATOM    578  CB  PHE A 488     -29.080  79.887  56.019  1.00 78.99           C  
ATOM    579  N   ASN A 489     -30.240  79.711  58.490  1.00 80.49           N  
ATOM    580  CA  ASN A 489     -31.054  79.599  59.706  1.00 80.96           C  
ATOM    581  C   ASN A 489     -32.559  79.752  59.522  1.00 81.47           C  
ATOM    582  O   ASN A 489     -33.118  79.410  58.476  1.00 81.41           O  
ATOM    583  N   VAL A 490     -33.211  80.230  60.580  1.00 82.15           N  
ATOM    584  CA  VAL A 490     -34.637  80.585  60.563  1.00 82.57           C  
ATOM    585  C   VAL A 490     -34.788  82.078  60.826  1.00 82.88           C  
ATOM    586  O   VAL A 490     -35.461  82.790  60.064  1.00 82.81           O  
ATOM    587  N   LYS A 491     -34.160  82.541  61.912  1.00 83.08           N  
ATOM    588  CA  LYS A 491     -33.975  83.974  62.173  1.00 83.11           C  
ATOM    589  C   LYS A 491     -33.017  84.639  61.185  1.00 83.05           C  
ATOM    590  O   LYS A 491     -33.445  85.385  60.296  1.00 83.21           O  
ATOM    591  N   ASP A 492     -31.722  84.369  61.337  1.00 82.84           N  
ATOM    592  CA  ASP A 492     -30.696  84.965  60.484  1.00 82.59           C  
ATOM    593  C   ASP A 492     -29.634  85.668  61.302  1.00 82.50           C  
ATOM    594  O   ASP A 492     -28.636  85.056  61.686  1.00 82.47           O  
ATOM    595  N   GLU A 507     -27.751  94.021  60.293  1.00 88.49           N  
ATOM    596  CA  GLU A 507     -26.932  92.820  60.400  1.00 88.73           C  
ATOM    597  C   GLU A 507     -25.551  93.012  59.765  1.00 88.81           C  
ATOM    598  O   GLU A 507     -24.827  93.954  60.108  1.00 88.92           O  
ATOM    599  N   LEU A 508     -25.200  92.117  58.838  1.00 88.68           N  
ATOM    600  CA  LEU A 508     -23.915  92.178  58.124  1.00 88.56           C  
ATOM    601  C   LEU A 508     -24.035  92.938  56.792  1.00 88.54           C  
ATOM    602  O   LEU A 508     -23.278  92.676  55.848  1.00 88.68           O  
ATOM    603  CB  LEU A 508     -23.377  90.758  57.867  1.00 88.53           C  
ATOM    604  CG  LEU A 508     -22.994  89.873  59.062  1.00 88.38           C  
ATOM    605  CD1 LEU A 508     -22.788  88.429  58.619  1.00 88.29           C  
ATOM    606  CD2 LEU A 508     -21.740  90.387  59.760  1.00 88.17           C  
ATOM    607  N   GLY A 509     -24.977  93.880  56.718  1.00 88.38           N  
ATOM    608  CA  GLY A 509     -25.184  94.676  55.510  1.00 88.25           C  
ATOM    609  C   GLY A 509     -24.042  95.637  55.231  1.00 88.23           C  
ATOM    610  O   GLY A 509     -23.600  95.784  54.083  1.00 88.28           O  
ATOM    611  N   ALA A 510     -23.543  96.260  56.296  1.00 88.14           N  
ATOM    612  CA  ALA A 510     -22.619  97.393  56.191  1.00 88.02           C  
ATOM    613  C   ALA A 510     -21.271  97.088  55.524  1.00 87.88           C  
ATOM    614  O   ALA A 510     -20.560  98.016  55.143  1.00 88.08           O  
ATOM    615  CB  ALA A 510     -22.393  98.020  57.575  1.00 87.96           C  
ATOM    616  N   MET A 511     -20.906  95.816  55.383  1.00 87.56           N  
ATOM    617  CA  MET A 511     -19.627  95.468  54.744  1.00 87.24           C  
ATOM    618  C   MET A 511     -19.711  95.437  53.201  1.00 86.74           C  
ATOM    619  O   MET A 511     -18.674  95.398  52.523  1.00 86.59           O  
ATOM    620  CB  MET A 511     -19.092  94.130  55.295  1.00 87.33           C  
ATOM    621  CG  MET A 511     -19.904  92.893  54.903  1.00 87.60           C  
ATOM    622  SD  MET A 511     -19.211  91.335  55.471  1.00 87.90           S  
ATOM    623  CE  MET A 511     -18.938  91.697  57.205  1.00 88.35           C  
ATOM    624  N   GLY A 512     -20.936  95.469  52.661  1.00 86.09           N  
ATOM    625  CA  GLY A 512     -21.174  95.268  51.222  1.00 85.54           C  
ATOM    626  C   GLY A 512     -21.562  93.836  50.866  1.00 84.99           C  
ATOM    627  O   GLY A 512     -21.827  93.509  49.707  1.00 84.82           O  
ATOM    628  N   MET A 513     -21.590  92.978  51.879  1.00 84.30           N  
ATOM    629  CA  MET A 513     -22.084  91.626  51.744  1.00 83.67           C  
ATOM    630  C   MET A 513     -23.590  91.654  52.029  1.00 82.99           C  
ATOM    631  O   MET A 513     -24.211  90.603  52.231  1.00 83.22           O  
ATOM    632  CB  MET A 513     -21.352  90.695  52.724  1.00 83.58           C  
ATOM    633  N   GLY A 514     -24.172  92.858  52.043  1.00 81.89           N  
ATOM    634  CA  GLY A 514     -25.592  93.031  52.292  1.00 81.09           C  
ATOM    635  C   GLY A 514     -26.446  92.320  51.266  1.00 80.29           C  
ATOM    636  O   GLY A 514     -27.094  91.315  51.578  1.00 80.43           O  
ATOM    637  N   ASP A 515     -26.440  92.828  50.036  1.00 79.24           N  
ATOM    638  CA  ASP A 515     -27.210  92.200  48.949  1.00 78.47           C  
ATOM    639  C   ASP A 515     -26.766  90.754  48.614  1.00 77.47           C  
ATOM    640  O   ASP A 515     -27.548  90.005  48.028  1.00 77.47           O  
ATOM    641  CB  ASP A 515     -27.250  93.080  47.681  1.00 78.49           C  
ATOM    642  CG  ASP A 515     -25.894  93.664  47.312  1.00 79.17           C  
ATOM    643  OD1 ASP A 515     -25.217  94.228  48.206  1.00 79.85           O  
ATOM    644  OD2 ASP A 515     -25.520  93.580  46.120  1.00 80.19           O  
ATOM    645  N   LEU A 516     -25.542  90.362  48.990  1.00 76.12           N  
ATOM    646  CA  LEU A 516     -25.108  88.962  48.857  1.00 75.12           C  
ATOM    647  C   LEU A 516     -25.783  88.063  49.902  1.00 74.31           C  
ATOM    648  O   LEU A 516     -26.679  87.287  49.564  1.00 74.19           O  
ATOM    649  CB  LEU A 516     -23.577  88.815  48.935  1.00 74.95           C  
ATOM    650  CG  LEU A 516     -23.032  87.386  48.747  1.00 74.43           C  
ATOM    651  CD1 LEU A 516     -23.668  86.699  47.544  1.00 73.48           C  
ATOM    652  CD2 LEU A 516     -21.518  87.368  48.614  1.00 73.29           C  
ATOM    653  N   LEU A 517     -25.375  88.175  51.165  1.00 73.24           N  
ATOM    654  CA  LEU A 517     -25.918  87.305  52.211  1.00 72.39           C  
ATOM    655  C   LEU A 517     -27.447  87.366  52.241  1.00 71.58           C  
ATOM    656  O   LEU A 517     -28.093  86.397  52.640  1.00 71.72           O  
ATOM    657  CB  LEU A 517     -25.324  87.645  53.582  1.00 72.27           C  
ATOM    658  N   SER A 518     -28.017  88.490  51.805  1.00 70.62           N  
ATOM    659  CA  SER A 518     -29.471  88.630  51.660  1.00 69.82           C  
ATOM    660  C   SER A 518     -30.044  87.923  50.434  1.00 69.05           C  
ATOM    661  O   SER A 518     -31.201  87.503  50.432  1.00 69.22           O  
ATOM    662  N   ALA A 519     -29.242  87.824  49.377  1.00 68.35           N  
ATOM    663  CA  ALA A 519     -29.580  86.987  48.219  1.00 67.60           C  
ATOM    664  C   ALA A 519     -29.388  85.516  48.583  1.00 66.79           C  
ATOM    665  O   ALA A 519     -30.222  84.678  48.239  1.00 66.81           O  
ATOM    666  CB  ALA A 519     -28.722  87.353  47.005  1.00 67.44           C  
ATOM    667  N   MET A 520     -28.292  85.222  49.284  1.00 65.77           N  
ATOM    668  CA  MET A 520     -28.016  83.878  49.780  1.00 65.38           C  
ATOM    669  C   MET A 520     -29.116  83.368  50.724  1.00 64.90           C  
ATOM    670  O   MET A 520     -29.415  82.174  50.736  1.00 64.80           O  
ATOM    671  CB  MET A 520     -26.664  83.823  50.502  1.00 65.58           C  
ATOM    672  CG  MET A 520     -25.456  84.237  49.652  1.00 66.24           C  
ATOM    673  SD  MET A 520     -23.885  83.460  50.128  1.00 68.91           S  
ATOM    674  CE  MET A 520     -23.998  83.377  51.916  1.00 68.30           C  
ATOM    675  N   PHE A 521     -29.712  84.267  51.510  1.00 64.32           N  
ATOM    676  CA  PHE A 521     -30.828  83.905  52.397  1.00 63.70           C  
ATOM    677  C   PHE A 521     -32.055  83.494  51.583  1.00 62.75           C  
ATOM    678  O   PHE A 521     -32.672  82.464  51.863  1.00 62.85           O  
ATOM    679  CB  PHE A 521     -31.180  85.058  53.363  1.00 63.88           C  
ATOM    680  CG  PHE A 521     -32.461  84.833  54.169  1.00 64.82           C  
ATOM    681  CD1 PHE A 521     -32.465  84.011  55.291  1.00 65.17           C  
ATOM    682  CD2 PHE A 521     -33.657  85.453  53.802  1.00 65.92           C  
ATOM    683  N   ASP A 522     -32.405  84.288  50.576  1.00 61.58           N  
ATOM    684  CA  ASP A 522     -33.612  84.016  49.796  1.00 60.82           C  
ATOM    685  C   ASP A 522     -33.467  82.720  48.976  1.00 60.01           C  
ATOM    686  O   ASP A 522     -34.420  81.939  48.873  1.00 60.25           O  
ATOM    687  CB  ASP A 522     -33.958  85.201  48.886  1.00 60.91           C  
ATOM    688  CG  ASP A 522     -34.146  86.506  49.658  1.00 61.07           C  
ATOM    689  N   PHE A 523     -32.279  82.490  48.407  1.00 58.63           N  
ATOM    690  CA  PHE A 523     -32.015  81.263  47.659  1.00 57.44           C  
ATOM    691  C   PHE A 523     -32.180  80.043  48.555  1.00 57.22           C  
ATOM    692  O   PHE A 523     -32.828  79.075  48.184  1.00 57.20           O  
ATOM    693  CB  PHE A 523     -30.604  81.262  47.057  1.00 56.86           C  
ATOM    694  CG  PHE A 523     -30.249  79.971  46.368  1.00 54.71           C  
ATOM    695  CD1 PHE A 523     -30.780  79.663  45.121  1.00 52.54           C  
ATOM    696  CD2 PHE A 523     -29.405  79.048  46.975  1.00 53.22           C  
ATOM    697  CE1 PHE A 523     -30.463  78.474  44.485  1.00 51.24           C  
ATOM    698  CE2 PHE A 523     -29.089  77.848  46.345  1.00 51.69           C  
ATOM    699  CZ  PHE A 523     -29.618  77.566  45.100  1.00 51.47           C  
ATOM    700  N   SER A 524     -31.592  80.104  49.740  1.00 56.97           N  
ATOM    701  CA  SER A 524     -31.608  78.977  50.667  1.00 57.11           C  
ATOM    702  C   SER A 524     -33.003  78.665  51.184  1.00 56.78           C  
ATOM    703  O   SER A 524     -33.348  77.499  51.379  1.00 56.74           O  
ATOM    704  CB  SER A 524     -30.686  79.265  51.834  1.00 57.21           C  
ATOM    705  OG  SER A 524     -29.437  79.710  51.332  1.00 58.31           O  
ATOM    706  N   GLU A 525     -33.793  79.713  51.409  1.00 56.27           N  
ATOM    707  CA  GLU A 525     -35.194  79.556  51.739  1.00 55.63           C  
ATOM    708  C   GLU A 525     -35.800  78.668  50.682  1.00 55.16           C  
ATOM    709  O   GLU A 525     -36.366  77.627  51.004  1.00 55.42           O  
ATOM    710  CB  GLU A 525     -35.910  80.910  51.762  1.00 55.96           C  
ATOM    711  N   LYS A 526     -35.652  79.067  49.419  1.00 54.49           N  
ATOM    712  CA  LYS A 526     -36.163  78.275  48.294  1.00 54.18           C  
ATOM    713  C   LYS A 526     -35.655  76.831  48.320  1.00 53.08           C  
ATOM    714  O   LYS A 526     -36.418  75.888  48.129  1.00 52.46           O  
ATOM    715  CB  LYS A 526     -35.807  78.920  46.946  1.00 54.55           C  
ATOM    716  CG  LYS A 526     -37.031  79.427  46.168  1.00 56.80           C  
ATOM    717  CD  LYS A 526     -36.691  79.819  44.713  1.00 58.94           C  
ATOM    718  CE  LYS A 526     -35.682  80.974  44.669  1.00 60.02           C  
ATOM    719  NZ  LYS A 526     -35.649  81.653  43.348  1.00 61.48           N  
ATOM    720  N   LEU A 527     -34.364  76.671  48.569  1.00 51.92           N  
ATOM    721  CA  LEU A 527     -33.759  75.366  48.542  1.00 51.45           C  
ATOM    722  C   LEU A 527     -34.336  74.483  49.633  1.00 51.41           C  
ATOM    723  O   LEU A 527     -34.599  73.308  49.399  1.00 51.45           O  
ATOM    724  CB  LEU A 527     -32.249  75.491  48.701  1.00 51.43           C  
ATOM    725  CG  LEU A 527     -31.425  74.217  48.514  1.00 51.29           C  
ATOM    726  CD1 LEU A 527     -31.597  73.673  47.099  1.00 50.85           C  
ATOM    727  CD2 LEU A 527     -29.946  74.483  48.843  1.00 50.93           C  
ATOM    728  N   ASN A 528     -34.559  75.053  50.814  1.00 51.40           N  
ATOM    729  CA  ASN A 528     -35.020  74.274  51.968  1.00 51.53           C  
ATOM    730  C   ASN A 528     -36.483  73.832  51.836  1.00 50.67           C  
ATOM    731  O   ASN A 528     -36.906  72.860  52.476  1.00 51.05           O  
ATOM    732  CB  ASN A 528     -34.796  75.045  53.284  1.00 52.02           C  
ATOM    733  CG  ASN A 528     -33.309  75.385  53.533  1.00 54.63           C  
ATOM    734  OD1 ASN A 528     -32.479  75.317  52.617  1.00 57.97           O  
ATOM    735  ND2 ASN A 528     -32.978  75.770  54.769  1.00 56.59           N  
ATOM    736  N   SER A 529     -37.251  74.522  50.998  1.00 49.51           N  
ATOM    737  CA  SER A 529     -38.650  74.155  50.769  1.00 48.68           C  
ATOM    738  C   SER A 529     -38.765  72.778  50.122  1.00 47.63           C  
ATOM    739  O   SER A 529     -39.727  72.049  50.368  1.00 47.90           O  
ATOM    740  CB  SER A 529     -39.335  75.190  49.885  1.00 48.75           C  
ATOM    741  OG  SER A 529     -38.681  75.279  48.629  1.00 50.20           O  
ATOM    742  N   LEU A 530     -37.775  72.429  49.299  1.00 46.33           N  
ATOM    743  CA  LEU A 530     -37.674  71.092  48.702  1.00 45.00           C  
ATOM    744  C   LEU A 530     -37.447  69.994  49.744  1.00 43.99           C  
ATOM    745  O   LEU A 530     -37.752  68.829  49.494  1.00 43.79           O  
ATOM    746  CB  LEU A 530     -36.528  71.051  47.686  1.00 44.95           C  
ATOM    747  CG  LEU A 530     -36.655  71.958  46.471  1.00 44.48           C  
ATOM    748  CD1 LEU A 530     -35.359  71.958  45.701  1.00 43.78           C  
ATOM    749  CD2 LEU A 530     -37.823  71.508  45.611  1.00 44.77           C  
ATOM    750  N   ALA A 531     -36.900  70.368  50.898  1.00 42.91           N  
ATOM    751  CA  ALA A 531     -36.546  69.421  51.960  1.00 42.18           C  
ATOM    752  C   ALA A 531     -35.684  68.251  51.449  1.00 41.17           C  
ATOM    753  O   ALA A 531     -35.996  67.088  51.682  1.00 41.21           O  
ATOM    754  CB  ALA A 531     -37.805  68.911  52.691  1.00 41.99           C  
ATOM    755  N   LEU A 532     -34.588  68.570  50.771  1.00 40.21           N  
ATOM    756  CA  LEU A 532     -33.687  67.544  50.272  1.00 39.72           C  
ATOM    757  C   LEU A 532     -33.088  66.721  51.411  1.00 39.64           C  
ATOM    758  O   LEU A 532     -32.696  67.283  52.429  1.00 39.88           O  
ATOM    759  CB  LEU A 532     -32.543  68.175  49.481  1.00 39.40           C  
ATOM    760  CG  LEU A 532     -32.851  69.021  48.243  1.00 38.94           C  
ATOM    761  CD1 LEU A 532     -31.520  69.350  47.546  1.00 38.19           C  
ATOM    762  CD2 LEU A 532     -33.835  68.327  47.282  1.00 36.43           C  
ATOM    763  N   THR A 533     -33.004  65.402  51.231  1.00 39.54           N  
ATOM    764  CA  THR A 533     -32.245  64.535  52.142  1.00 39.43           C  
ATOM    765  C   THR A 533     -30.776  64.826  51.928  1.00 40.00           C  
ATOM    766  O   THR A 533     -30.433  65.581  51.019  1.00 39.86           O  
ATOM    767  CB  THR A 533     -32.492  63.032  51.880  1.00 39.39           C  
ATOM    768  OG1 THR A 533     -31.987  62.668  50.591  1.00 39.10           O  
ATOM    769  CG2 THR A 533     -33.975  62.698  51.943  1.00 38.85           C  
ATOM    770  N   GLU A 534     -29.905  64.231  52.744  1.00 40.85           N  
ATOM    771  CA  GLU A 534     -28.457  64.475  52.614  1.00 41.67           C  
ATOM    772  C   GLU A 534     -27.908  63.876  51.331  1.00 41.25           C  
ATOM    773  O   GLU A 534     -27.032  64.466  50.715  1.00 41.67           O  
ATOM    774  CB  GLU A 534     -27.654  63.938  53.811  1.00 42.32           C  
ATOM    775  CG  GLU A 534     -27.636  64.878  55.015  1.00 45.31           C  
ATOM    776  CD  GLU A 534     -26.549  65.953  54.949  1.00 49.08           C  
ATOM    777  OE1 GLU A 534     -25.340  65.596  54.985  1.00 51.48           O  
ATOM    778  OE2 GLU A 534     -26.913  67.159  54.906  1.00 50.66           O  
ATOM    779  N   GLU A 535     -28.399  62.705  50.938  1.00 40.61           N  
ATOM    780  CA  GLU A 535     -28.023  62.131  49.649  1.00 40.23           C  
ATOM    781  C   GLU A 535     -28.425  63.036  48.489  1.00 39.38           C  
ATOM    782  O   GLU A 535     -27.640  63.230  47.561  1.00 39.10           O  
ATOM    783  CB  GLU A 535     -28.665  60.769  49.438  1.00 40.44           C  
ATOM    784  CG  GLU A 535     -28.032  59.669  50.238  1.00 42.37           C  
ATOM    785  CD  GLU A 535     -28.756  58.344  50.068  1.00 45.60           C  
ATOM    786  OE1 GLU A 535     -30.017  58.343  49.962  1.00 46.82           O  
ATOM    787  OE2 GLU A 535     -28.058  57.303  50.043  1.00 48.05           O  
ATOM    788  N   GLU A 536     -29.649  63.562  48.535  1.00 38.17           N  
ATOM    789  CA  GLU A 536     -30.150  64.418  47.466  1.00 37.48           C  
ATOM    790  C   GLU A 536     -29.304  65.687  47.390  1.00 36.89           C  
ATOM    791  O   GLU A 536     -28.835  66.079  46.322  1.00 36.41           O  
ATOM    792  CB  GLU A 536     -31.641  64.748  47.684  1.00 37.69           C  
ATOM    793  CG  GLU A 536     -32.561  63.517  47.528  1.00 37.97           C  
ATOM    794  CD  GLU A 536     -34.049  63.778  47.761  1.00 37.89           C  
ATOM    795  OE1 GLU A 536     -34.432  64.759  48.431  1.00 37.54           O  
ATOM    796  OE2 GLU A 536     -34.855  62.961  47.281  1.00 37.71           O  
ATOM    797  N   LEU A 537     -29.083  66.306  48.541  1.00 36.25           N  
ATOM    798  CA  LEU A 537     -28.275  67.525  48.617  1.00 35.99           C  
ATOM    799  C   LEU A 537     -26.824  67.287  48.150  1.00 35.70           C  
ATOM    800  O   LEU A 537     -26.257  68.094  47.390  1.00 35.76           O  
ATOM    801  CB  LEU A 537     -28.308  68.079  50.044  1.00 35.82           C  
ATOM    802  CG  LEU A 537     -27.577  69.379  50.337  1.00 35.44           C  
ATOM    803  CD1 LEU A 537     -28.272  70.528  49.619  1.00 34.97           C  
ATOM    804  CD2 LEU A 537     -27.509  69.583  51.848  1.00 33.10           C  
ATOM    805  N   GLY A 538     -26.231  66.187  48.596  1.00 35.25           N  
ATOM    806  CA  GLY A 538     -24.859  65.850  48.207  1.00 35.33           C  
ATOM    807  C   GLY A 538     -24.713  65.717  46.701  1.00 35.30           C  
ATOM    808  O   GLY A 538     -23.779  66.229  46.096  1.00 35.72           O  
ATOM    809  N   LEU A 539     -25.679  65.046  46.097  1.00 35.08           N  
ATOM    810  CA  LEU A 539     -25.652  64.737  44.694  1.00 34.83           C  
ATOM    811  C   LEU A 539     -26.061  65.981  43.901  1.00 34.35           C  
ATOM    812  O   LEU A 539     -25.530  66.244  42.817  1.00 34.19           O  
ATOM    813  CB  LEU A 539     -26.588  63.551  44.433  1.00 35.10           C  
ATOM    814  CG  LEU A 539     -26.415  62.757  43.139  1.00 36.77           C  
ATOM    815  CD1 LEU A 539     -24.946  62.547  42.775  1.00 37.83           C  
ATOM    816  CD2 LEU A 539     -27.117  61.431  43.247  1.00 38.05           C  
ATOM    817  N   PHE A 540     -26.988  66.763  44.447  1.00 33.56           N  
ATOM    818  CA  PHE A 540     -27.302  68.049  43.845  1.00 33.14           C  
ATOM    819  C   PHE A 540     -26.049  68.916  43.833  1.00 32.57           C  
ATOM    820  O   PHE A 540     -25.690  69.480  42.811  1.00 32.93           O  
ATOM    821  CB  PHE A 540     -28.459  68.757  44.566  1.00 33.15           C  
ATOM    822  CG  PHE A 540     -28.730  70.145  44.055  1.00 33.54           C  
ATOM    823  CD1 PHE A 540     -29.158  70.352  42.756  1.00 34.83           C  
ATOM    824  CD2 PHE A 540     -28.526  71.254  44.863  1.00 35.22           C  
ATOM    825  CE1 PHE A 540     -29.405  71.649  42.274  1.00 35.19           C  
ATOM    826  CE2 PHE A 540     -28.761  72.541  44.389  1.00 35.33           C  
ATOM    827  CZ  PHE A 540     -29.205  72.735  43.095  1.00 34.79           C  
ATOM    828  N   THR A 541     -25.362  69.005  44.960  1.00 32.04           N  
ATOM    829  CA  THR A 541     -24.161  69.836  45.045  1.00 31.35           C  
ATOM    830  C   THR A 541     -23.138  69.480  43.955  1.00 31.42           C  
ATOM    831  O   THR A 541     -22.575  70.374  43.319  1.00 31.70           O  
ATOM    832  CB  THR A 541     -23.541  69.722  46.441  1.00 31.19           C  
ATOM    833  OG1 THR A 541     -24.510  70.179  47.379  1.00 30.66           O  
ATOM    834  CG2 THR A 541     -22.261  70.541  46.561  1.00 28.79           C  
ATOM    835  N   ALA A 542     -22.928  68.181  43.743  1.00 31.31           N  
ATOM    836  CA  ALA A 542     -22.018  67.664  42.714  1.00 30.92           C  
ATOM    837  C   ALA A 542     -22.521  68.050  41.345  1.00 30.84           C  
ATOM    838  O   ALA A 542     -21.733  68.407  40.476  1.00 30.84           O  
ATOM    839  CB  ALA A 542     -21.905  66.155  42.822  1.00 30.46           C  
ATOM    840  N   VAL A 543     -23.838  67.995  41.151  1.00 31.03           N  
ATOM    841  CA  VAL A 543     -24.411  68.363  39.867  1.00 31.24           C  
ATOM    842  C   VAL A 543     -24.101  69.831  39.590  1.00 32.25           C  
ATOM    843  O   VAL A 543     -23.698  70.169  38.485  1.00 33.00           O  
ATOM    844  CB  VAL A 543     -25.921  68.084  39.776  1.00 31.00           C  
ATOM    845  CG1 VAL A 543     -26.550  68.898  38.643  1.00 30.77           C  
ATOM    846  CG2 VAL A 543     -26.174  66.617  39.567  1.00 29.95           C  
ATOM    847  N   VAL A 544     -24.246  70.685  40.601  1.00 33.09           N  
ATOM    848  CA  VAL A 544     -23.949  72.113  40.466  1.00 33.70           C  
ATOM    849  C   VAL A 544     -22.495  72.363  40.008  1.00 34.97           C  
ATOM    850  O   VAL A 544     -22.261  73.114  39.049  1.00 35.61           O  
ATOM    851  CB  VAL A 544     -24.270  72.878  41.784  1.00 33.56           C  
ATOM    852  CG1 VAL A 544     -23.712  74.298  41.750  1.00 32.61           C  
ATOM    853  CG2 VAL A 544     -25.774  72.907  42.011  1.00 32.98           C  
ATOM    854  N   LEU A 545     -21.532  71.714  40.658  1.00 36.00           N  
ATOM    855  CA  LEU A 545     -20.126  71.878  40.308  1.00 36.99           C  
ATOM    856  C   LEU A 545     -19.835  71.542  38.862  1.00 38.15           C  
ATOM    857  O   LEU A 545     -19.079  72.261  38.209  1.00 38.91           O  
ATOM    858  CB  LEU A 545     -19.230  70.998  41.185  1.00 37.31           C  
ATOM    859  CG  LEU A 545     -17.738  70.989  40.810  1.00 37.34           C  
ATOM    860  CD1 LEU A 545     -17.209  72.423  40.507  1.00 36.98           C  
ATOM    861  CD2 LEU A 545     -16.946  70.329  41.920  1.00 36.81           C  
ATOM    862  N   VAL A 546     -20.402  70.443  38.363  1.00 39.26           N  
ATOM    863  CA  VAL A 546     -20.076  69.984  36.999  1.00 39.93           C  
ATOM    864  C   VAL A 546     -21.034  70.586  35.975  1.00 40.83           C  
ATOM    865  O   VAL A 546     -20.913  70.323  34.789  1.00 41.06           O  
ATOM    866  CB  VAL A 546     -20.036  68.423  36.871  1.00 39.87           C  
ATOM    867  CG1 VAL A 546     -19.188  67.814  37.981  1.00 38.38           C  
ATOM    868  CG2 VAL A 546     -21.449  67.815  36.862  1.00 40.21           C  
ATOM    869  N   SER A 547     -21.975  71.396  36.445  1.00 41.99           N  
ATOM    870  CA  SER A 547     -22.934  72.077  35.579  1.00 42.73           C  
ATOM    871  C   SER A 547     -22.525  73.516  35.382  1.00 44.05           C  
ATOM    872  O   SER A 547     -23.306  74.303  34.879  1.00 43.99           O  
ATOM    873  CB  SER A 547     -24.346  72.027  36.184  1.00 42.43           C  
ATOM    874  OG  SER A 547     -24.837  70.700  36.191  1.00 41.22           O  
ATOM    875  N   ALA A 548     -21.299  73.855  35.781  1.00 46.12           N  
ATOM    876  CA  ALA A 548     -20.748  75.199  35.601  1.00 47.55           C  
ATOM    877  C   ALA A 548     -20.557  75.537  34.118  1.00 49.23           C  
ATOM    878  O   ALA A 548     -20.494  74.646  33.267  1.00 49.39           O  
ATOM    879  CB  ALA A 548     -19.420  75.308  36.334  1.00 47.56           C  
ATOM    880  N   ASP A 549     -20.464  76.830  33.813  1.00 51.26           N  
ATOM    881  CA  ASP A 549     -20.196  77.285  32.451  1.00 52.97           C  
ATOM    882  C   ASP A 549     -18.890  76.689  31.888  1.00 53.97           C  
ATOM    883  O   ASP A 549     -17.846  76.721  32.548  1.00 53.80           O  
ATOM    884  CB  ASP A 549     -20.127  78.812  32.416  1.00 53.53           C  
ATOM    885  CG  ASP A 549     -19.824  79.344  31.026  1.00 55.49           C  
ATOM    886  OD1 ASP A 549     -20.779  79.527  30.233  1.00 58.32           O  
ATOM    887  OD2 ASP A 549     -18.626  79.554  30.728  1.00 58.07           O  
ATOM    888  N   ARG A 550     -18.955  76.158  30.666  1.00 55.28           N  
ATOM    889  CA  ARG A 550     -17.829  75.411  30.088  1.00 56.23           C  
ATOM    890  C   ARG A 550     -16.947  76.218  29.128  1.00 57.10           C  
ATOM    891  O   ARG A 550     -16.222  75.621  28.310  1.00 57.19           O  
ATOM    892  CB  ARG A 550     -18.342  74.189  29.331  1.00 56.26           C  
ATOM    893  CG  ARG A 550     -19.037  73.182  30.180  1.00 57.08           C  
ATOM    894  CD  ARG A 550     -19.488  72.016  29.330  1.00 58.26           C  
ATOM    895  NE  ARG A 550     -20.652  71.365  29.916  1.00 59.99           N  
ATOM    896  CZ  ARG A 550     -21.590  70.712  29.232  1.00 61.66           C  
ATOM    897  NH1 ARG A 550     -22.598  70.167  29.890  1.00 62.55           N  
ATOM    898  NH2 ARG A 550     -21.537  70.596  27.905  1.00 61.69           N  
ATOM    899  N   SER A 551     -17.001  77.550  29.193  1.00 57.91           N  
ATOM    900  CA  SER A 551     -16.087  78.341  28.369  1.00 58.70           C  
ATOM    901  C   SER A 551     -14.683  77.938  28.796  1.00 58.95           C  
ATOM    902  O   SER A 551     -14.348  78.033  29.978  1.00 59.33           O  
ATOM    903  CB  SER A 551     -16.301  79.855  28.531  1.00 58.87           C  
ATOM    904  OG  SER A 551     -16.186  80.262  29.889  1.00 60.05           O  
ATOM    905  N   GLY A 552     -13.903  77.418  27.847  1.00 59.08           N  
ATOM    906  CA  GLY A 552     -12.495  77.069  28.072  1.00 58.90           C  
ATOM    907  C   GLY A 552     -12.180  75.586  28.175  1.00 59.00           C  
ATOM    908  O   GLY A 552     -11.054  75.222  28.532  1.00 59.24           O  
ATOM    909  N   MET A 553     -13.144  74.720  27.856  1.00 58.83           N  
ATOM    910  CA  MET A 553     -12.951  73.283  28.062  1.00 58.71           C  
ATOM    911  C   MET A 553     -12.077  72.686  26.975  1.00 58.55           C  
ATOM    912  O   MET A 553     -12.339  72.891  25.794  1.00 58.84           O  
ATOM    913  CB  MET A 553     -14.291  72.528  28.106  1.00 58.71           C  
ATOM    914  CG  MET A 553     -15.003  72.594  29.444  1.00 58.85           C  
ATOM    915  SD  MET A 553     -14.031  72.059  30.875  1.00 58.72           S  
ATOM    916  CE  MET A 553     -14.876  72.999  32.143  1.00 57.69           C  
ATOM    917  N   GLU A 554     -11.050  71.939  27.378  1.00 58.18           N  
ATOM    918  CA  GLU A 554     -10.280  71.139  26.434  1.00 58.08           C  
ATOM    919  C   GLU A 554     -11.169  70.046  25.859  1.00 57.75           C  
ATOM    920  O   GLU A 554     -11.314  69.948  24.638  1.00 58.26           O  
ATOM    921  CB  GLU A 554      -9.035  70.537  27.083  1.00 58.30           C  
ATOM    922  CG  GLU A 554      -7.911  71.548  27.264  1.00 59.37           C  
ATOM    923  CD  GLU A 554      -6.762  71.016  28.098  1.00 61.35           C  
ATOM    924  OE1 GLU A 554      -6.915  69.935  28.715  1.00 63.20           O  
ATOM    925  OE2 GLU A 554      -5.705  71.688  28.142  1.00 62.39           O  
ATOM    926  N   ASN A 555     -11.775  69.235  26.728  1.00 56.98           N  
ATOM    927  CA  ASN A 555     -12.793  68.290  26.281  1.00 55.97           C  
ATOM    928  C   ASN A 555     -14.149  68.511  26.949  1.00 55.22           C  
ATOM    929  O   ASN A 555     -14.488  67.852  27.927  1.00 55.43           O  
ATOM    930  CB  ASN A 555     -12.335  66.849  26.464  1.00 55.78           C  
ATOM    931  CG  ASN A 555     -13.188  65.879  25.666  1.00 56.20           C  
ATOM    932  OD1 ASN A 555     -13.996  66.299  24.831  1.00 56.99           O  
ATOM    933  ND2 ASN A 555     -13.012  64.583  25.904  1.00 55.81           N  
ATOM    934  N   SER A 556     -14.929  69.426  26.385  1.00 54.11           N  
ATOM    935  CA  SER A 556     -16.284  69.698  26.849  1.00 53.34           C  
ATOM    936  C   SER A 556     -17.225  68.480  26.816  1.00 52.39           C  
ATOM    937  O   SER A 556     -18.133  68.383  27.631  1.00 52.17           O  
ATOM    938  CB  SER A 556     -16.890  70.825  26.019  1.00 53.48           C  
ATOM    939  OG  SER A 556     -17.919  71.498  26.735  1.00 54.86           O  
ATOM    940  N   ALA A 557     -17.021  67.557  25.884  1.00 51.49           N  
ATOM    941  CA  ALA A 557     -17.843  66.340  25.835  1.00 50.99           C  
ATOM    942  C   ALA A 557     -17.667  65.450  27.080  1.00 50.50           C  
ATOM    943  O   ALA A 557     -18.621  64.836  27.564  1.00 50.52           O  
ATOM    944  CB  ALA A 557     -17.555  65.540  24.567  1.00 50.75           C  
ATOM    945  N   SER A 558     -16.447  65.374  27.597  1.00 49.82           N  
ATOM    946  CA  SER A 558     -16.190  64.556  28.781  1.00 49.16           C  
ATOM    947  C   SER A 558     -16.865  65.162  30.016  1.00 48.54           C  
ATOM    948  O   SER A 558     -17.367  64.435  30.878  1.00 47.62           O  
ATOM    949  CB  SER A 558     -14.687  64.407  29.007  1.00 48.95           C  
ATOM    950  OG  SER A 558     -14.067  65.679  29.130  1.00 49.36           O  
ATOM    951  N   VAL A 559     -16.861  66.495  30.088  1.00 48.30           N  
ATOM    952  CA  VAL A 559     -17.525  67.208  31.174  1.00 48.16           C  
ATOM    953  C   VAL A 559     -19.008  66.943  31.096  1.00 48.19           C  
ATOM    954  O   VAL A 559     -19.663  66.741  32.107  1.00 48.29           O  
ATOM    955  CB  VAL A 559     -17.282  68.727  31.124  1.00 48.13           C  
ATOM    956  CG1 VAL A 559     -18.234  69.462  32.090  1.00 47.78           C  
ATOM    957  CG2 VAL A 559     -15.831  69.035  31.449  1.00 47.52           C  
ATOM    958  N   GLU A 560     -19.529  66.909  29.880  1.00 48.17           N  
ATOM    959  CA  GLU A 560     -20.938  66.676  29.700  1.00 48.15           C  
ATOM    960  C   GLU A 560     -21.365  65.237  30.020  1.00 47.19           C  
ATOM    961  O   GLU A 560     -22.429  65.021  30.595  1.00 47.11           O  
ATOM    962  CB  GLU A 560     -21.366  67.062  28.295  1.00 48.68           C  
ATOM    963  CG  GLU A 560     -22.869  67.120  28.171  1.00 51.27           C  
ATOM    964  CD  GLU A 560     -23.333  67.468  26.796  1.00 55.60           C  
ATOM    965  OE1 GLU A 560     -22.534  68.077  26.030  1.00 58.05           O  
ATOM    966  OE2 GLU A 560     -24.511  67.130  26.494  1.00 58.47           O  
ATOM    967  N   GLN A 561     -20.568  64.250  29.661  1.00 46.41           N  
ATOM    968  CA  GLN A 561     -20.916  62.879  30.030  1.00 46.36           C  
ATOM    969  C   GLN A 561     -20.993  62.718  31.543  1.00 44.91           C  
ATOM    970  O   GLN A 561     -21.824  61.968  32.056  1.00 44.58           O  
ATOM    971  CB  GLN A 561     -19.912  61.890  29.450  1.00 47.13           C  
ATOM    972  CG  GLN A 561     -20.054  61.738  27.942  1.00 51.05           C  
ATOM    973  CD  GLN A 561     -19.079  60.732  27.333  1.00 56.36           C  
ATOM    974  OE1 GLN A 561     -18.516  59.865  28.032  1.00 59.86           O  
ATOM    975  NE2 GLN A 561     -18.882  60.839  26.011  1.00 59.37           N  
ATOM    976  N   LEU A 562     -20.120  63.437  32.243  1.00 43.60           N  
ATOM    977  CA  LEU A 562     -20.072  63.415  33.698  1.00 42.65           C  
ATOM    978  C   LEU A 562     -21.319  64.083  34.288  1.00 41.88           C  
ATOM    979  O   LEU A 562     -21.938  63.560  35.219  1.00 41.79           O  
ATOM    980  CB  LEU A 562     -18.806  64.120  34.186  1.00 42.50           C  
ATOM    981  CG  LEU A 562     -18.572  64.170  35.693  1.00 42.91           C  
ATOM    982  CD1 LEU A 562     -18.539  62.746  36.276  1.00 41.90           C  
ATOM    983  CD2 LEU A 562     -17.297  64.956  36.010  1.00 42.09           C  
ATOM    984  N   GLN A 563     -21.686  65.235  33.737  1.00 40.80           N  
ATOM    985  CA  GLN A 563     -22.898  65.920  34.140  1.00 40.18           C  
ATOM    986  C   GLN A 563     -24.105  64.997  34.018  1.00 39.75           C  
ATOM    987  O   GLN A 563     -24.908  64.894  34.950  1.00 40.17           O  
ATOM    988  CB  GLN A 563     -23.114  67.174  33.293  1.00 40.10           C  
ATOM    989  CG  GLN A 563     -24.269  68.047  33.780  1.00 40.33           C  
ATOM    990  CD  GLN A 563     -24.649  69.147  32.804  1.00 39.93           C  
ATOM    991  OE1 GLN A 563     -25.081  70.230  33.206  1.00 39.28           O  
ATOM    992  NE2 GLN A 563     -24.515  68.865  31.520  1.00 39.53           N  
ATOM    993  N   GLU A 564     -24.222  64.320  32.876  1.00 39.15           N  
ATOM    994  CA  GLU A 564     -25.368  63.450  32.595  1.00 38.39           C  
ATOM    995  C   GLU A 564     -25.391  62.247  33.541  1.00 38.04           C  
ATOM    996  O   GLU A 564     -26.463  61.834  34.009  1.00 37.70           O  
ATOM    997  CB  GLU A 564     -25.354  62.987  31.133  1.00 38.09           C  
ATOM    998  N   THR A 565     -24.213  61.692  33.828  1.00 37.51           N  
ATOM    999  CA  THR A 565     -24.112  60.597  34.786  1.00 37.21           C  
ATOM   1000  C   THR A 565     -24.694  61.017  36.120  1.00 36.96           C  
ATOM   1001  O   THR A 565     -25.487  60.270  36.708  1.00 37.42           O  
ATOM   1002  CB  THR A 565     -22.654  60.112  34.970  1.00 37.28           C  
ATOM   1003  OG1 THR A 565     -22.264  59.335  33.832  1.00 38.00           O  
ATOM   1004  CG2 THR A 565     -22.518  59.240  36.201  1.00 37.40           C  
ATOM   1005  N   LEU A 566     -24.324  62.215  36.580  1.00 36.53           N  
ATOM   1006  CA  LEU A 566     -24.728  62.698  37.900  1.00 36.17           C  
ATOM   1007  C   LEU A 566     -26.206  63.054  37.948  1.00 36.37           C  
ATOM   1008  O   LEU A 566     -26.885  62.779  38.936  1.00 35.99           O  
ATOM   1009  CB  LEU A 566     -23.882  63.897  38.319  1.00 36.07           C  
ATOM   1010  CG  LEU A 566     -22.406  63.629  38.636  1.00 35.82           C  
ATOM   1011  CD1 LEU A 566     -21.685  64.953  38.751  1.00 35.51           C  
ATOM   1012  CD2 LEU A 566     -22.210  62.774  39.901  1.00 33.82           C  
ATOM   1013  N   LEU A 567     -26.706  63.653  36.873  1.00 37.09           N  
ATOM   1014  CA  LEU A 567     -28.129  63.967  36.761  1.00 37.43           C  
ATOM   1015  C   LEU A 567     -28.953  62.702  36.646  1.00 38.10           C  
ATOM   1016  O   LEU A 567     -30.090  62.668  37.051  1.00 38.34           O  
ATOM   1017  CB  LEU A 567     -28.388  64.844  35.543  1.00 37.27           C  
ATOM   1018  CG  LEU A 567     -27.767  66.235  35.585  1.00 37.38           C  
ATOM   1019  CD1 LEU A 567     -27.721  66.841  34.177  1.00 36.92           C  
ATOM   1020  CD2 LEU A 567     -28.524  67.134  36.568  1.00 36.38           C  
ATOM   1021  N   ARG A 568     -28.384  61.660  36.071  1.00 39.41           N  
ATOM   1022  CA  ARG A 568     -29.085  60.389  35.960  1.00 40.75           C  
ATOM   1023  C   ARG A 568     -29.307  59.809  37.362  1.00 40.40           C  
ATOM   1024  O   ARG A 568     -30.409  59.376  37.700  1.00 40.24           O  
ATOM   1025  CB  ARG A 568     -28.268  59.431  35.084  1.00 41.65           C  
ATOM   1026  CG  ARG A 568     -28.930  58.077  34.767  1.00 46.04           C  
ATOM   1027  CD  ARG A 568     -27.946  57.122  34.025  1.00 51.37           C  
ATOM   1028  NE  ARG A 568     -26.724  56.860  34.812  1.00 55.86           N  
ATOM   1029  CZ  ARG A 568     -25.766  55.985  34.482  1.00 58.54           C  
ATOM   1030  NH1 ARG A 568     -25.870  55.253  33.373  1.00 59.28           N  
ATOM   1031  NH2 ARG A 568     -24.697  55.834  35.276  1.00 58.93           N  
ATOM   1032  N   ALA A 569     -28.251  59.828  38.173  1.00 40.07           N  
ATOM   1033  CA  ALA A 569     -28.303  59.312  39.523  1.00 39.92           C  
ATOM   1034  C   ALA A 569     -29.275  60.119  40.367  1.00 40.21           C  
ATOM   1035  O   ALA A 569     -30.099  59.545  41.088  1.00 40.15           O  
ATOM   1036  CB  ALA A 569     -26.939  59.352  40.134  1.00 39.99           C  
ATOM   1037  N   LEU A 570     -29.181  61.449  40.258  1.00 40.13           N  
ATOM   1038  CA  LEU A 570     -30.044  62.361  41.011  1.00 39.79           C  
ATOM   1039  C   LEU A 570     -31.517  62.120  40.725  1.00 39.92           C  
ATOM   1040  O   LEU A 570     -32.356  62.213  41.616  1.00 39.83           O  
ATOM   1041  CB  LEU A 570     -29.688  63.818  40.695  1.00 39.47           C  
ATOM   1042  CG  LEU A 570     -30.410  64.908  41.500  1.00 38.18           C  
ATOM   1043  CD1 LEU A 570     -30.238  64.696  43.001  1.00 35.82           C  
ATOM   1044  CD2 LEU A 570     -29.904  66.280  41.081  1.00 36.06           C  
ATOM   1045  N   ARG A 571     -31.825  61.805  39.477  1.00 40.55           N  
ATOM   1046  CA  ARG A 571     -33.199  61.565  39.064  1.00 41.15           C  
ATOM   1047  C   ARG A 571     -33.703  60.248  39.641  1.00 41.20           C  
ATOM   1048  O   ARG A 571     -34.819  60.160  40.159  1.00 41.75           O  
ATOM   1049  CB  ARG A 571     -33.270  61.539  37.553  1.00 41.50           C  
ATOM   1050  CG  ARG A 571     -34.661  61.676  36.963  1.00 44.08           C  
ATOM   1051  CD  ARG A 571     -34.540  61.763  35.441  1.00 47.79           C  
ATOM   1052  NE  ARG A 571     -35.835  61.689  34.771  1.00 51.70           N  
ATOM   1053  CZ  ARG A 571     -36.562  60.578  34.616  1.00 54.52           C  
ATOM   1054  NH1 ARG A 571     -36.149  59.407  35.108  1.00 55.93           N  
ATOM   1055  NH2 ARG A 571     -37.733  60.641  33.983  1.00 55.42           N  
ATOM   1056  N   ALA A 572     -32.883  59.216  39.542  1.00 41.24           N  
ATOM   1057  CA  ALA A 572     -33.193  57.970  40.189  1.00 41.35           C  
ATOM   1058  C   ALA A 572     -33.474  58.273  41.659  1.00 41.65           C  
ATOM   1059  O   ALA A 572     -34.567  58.024  42.134  1.00 41.79           O  
ATOM   1060  CB  ALA A 572     -32.043  56.994  40.040  1.00 41.15           C  
ATOM   1061  N   LEU A 573     -32.507  58.865  42.355  1.00 42.28           N  
ATOM   1062  CA  LEU A 573     -32.604  59.071  43.812  1.00 42.65           C  
ATOM   1063  C   LEU A 573     -33.888  59.771  44.182  1.00 43.16           C  
ATOM   1064  O   LEU A 573     -34.625  59.314  45.046  1.00 43.51           O  
ATOM   1065  CB  LEU A 573     -31.414  59.883  44.348  1.00 42.51           C  
ATOM   1066  CG  LEU A 573     -31.299  60.065  45.871  1.00 42.50           C  
ATOM   1067  CD1 LEU A 573     -31.501  58.746  46.611  1.00 41.20           C  
ATOM   1068  CD2 LEU A 573     -29.949  60.683  46.222  1.00 40.93           C  
ATOM   1069  N   VAL A 574     -34.158  60.873  43.504  1.00 43.57           N  
ATOM   1070  CA  VAL A 574     -35.324  61.665  43.796  1.00 44.04           C  
ATOM   1071  C   VAL A 574     -36.624  60.909  43.551  1.00 44.89           C  
ATOM   1072  O   VAL A 574     -37.605  61.169  44.228  1.00 45.30           O  
ATOM   1073  CB  VAL A 574     -35.293  62.978  42.994  1.00 43.93           C  
ATOM   1074  CG1 VAL A 574     -36.653  63.516  42.811  1.00 44.21           C  
ATOM   1075  CG2 VAL A 574     -34.419  64.001  43.709  1.00 43.82           C  
ATOM   1076  N   LEU A 575     -36.647  59.979  42.598  1.00 46.06           N  
ATOM   1077  CA  LEU A 575     -37.887  59.251  42.271  1.00 46.85           C  
ATOM   1078  C   LEU A 575     -38.121  58.012  43.136  1.00 47.31           C  
ATOM   1079  O   LEU A 575     -39.263  57.595  43.330  1.00 47.40           O  
ATOM   1080  CB  LEU A 575     -37.934  58.874  40.791  1.00 47.19           C  
ATOM   1081  CG  LEU A 575     -38.597  59.921  39.889  1.00 48.59           C  
ATOM   1082  CD1 LEU A 575     -38.249  59.640  38.432  1.00 50.31           C  
ATOM   1083  CD2 LEU A 575     -40.120  59.964  40.082  1.00 48.74           C  
ATOM   1084  N   LYS A 576     -37.046  57.417  43.634  1.00 48.03           N  
ATOM   1085  CA  LYS A 576     -37.135  56.402  44.686  1.00 48.80           C  
ATOM   1086  C   LYS A 576     -37.695  57.049  45.957  1.00 48.93           C  
ATOM   1087  O   LYS A 576     -38.520  56.452  46.650  1.00 49.73           O  
ATOM   1088  CB  LYS A 576     -35.749  55.776  44.948  1.00 49.03           C  
ATOM   1089  CG  LYS A 576     -35.665  54.788  46.138  1.00 50.50           C  
ATOM   1090  CD  LYS A 576     -35.030  55.407  47.411  1.00 51.73           C  
ATOM   1091  CE  LYS A 576     -34.854  54.365  48.538  1.00 52.06           C  
ATOM   1092  N   ASN A 577     -37.258  58.277  46.236  1.00 48.92           N  
ATOM   1093  CA  ASN A 577     -37.605  58.980  47.472  1.00 48.73           C  
ATOM   1094  C   ASN A 577     -39.033  59.497  47.474  1.00 49.01           C  
ATOM   1095  O   ASN A 577     -39.763  59.260  48.438  1.00 49.29           O  
ATOM   1096  CB  ASN A 577     -36.626  60.142  47.738  1.00 48.58           C  
ATOM   1097  CG  ASN A 577     -35.342  59.693  48.421  1.00 47.60           C  
ATOM   1098  OD1 ASN A 577     -35.219  58.557  48.826  1.00 47.13           O  
ATOM   1099  ND2 ASN A 577     -34.389  60.601  48.558  1.00 47.84           N  
ATOM   1100  N   ARG A 578     -39.424  60.213  46.416  1.00 49.31           N  
ATOM   1101  CA  ARG A 578     -40.771  60.792  46.315  1.00 49.64           C  
ATOM   1102  C   ARG A 578     -41.426  60.567  44.943  1.00 49.91           C  
ATOM   1103  O   ARG A 578     -41.503  61.499  44.130  1.00 50.02           O  
ATOM   1104  CB  ARG A 578     -40.739  62.284  46.630  1.00 49.63           C  
ATOM   1105  CG  ARG A 578     -39.991  62.648  47.900  1.00 50.64           C  
ATOM   1106  CD  ARG A 578     -40.478  63.983  48.480  1.00 52.09           C  
ATOM   1107  NE  ARG A 578     -41.770  63.828  49.161  1.00 53.47           N  
ATOM   1108  CZ  ARG A 578     -42.857  64.592  49.000  1.00 54.04           C  
ATOM   1109  NH1 ARG A 578     -42.871  65.639  48.175  1.00 54.66           N  
ATOM   1110  NH2 ARG A 578     -43.951  64.310  49.704  1.00 54.33           N  
ATOM   1111  N   PRO A 579     -41.929  59.334  44.693  1.00 50.34           N  
ATOM   1112  CA  PRO A 579     -42.575  58.953  43.413  1.00 50.54           C  
ATOM   1113  C   PRO A 579     -43.781  59.802  42.946  1.00 50.90           C  
ATOM   1114  O   PRO A 579     -44.015  59.933  41.738  1.00 51.30           O  
ATOM   1115  CB  PRO A 579     -43.005  57.506  43.659  1.00 50.45           C  
ATOM   1116  CG  PRO A 579     -42.070  57.002  44.699  1.00 50.44           C  
ATOM   1117  CD  PRO A 579     -41.748  58.164  45.580  1.00 50.26           C  
ATOM   1118  N   LEU A 580     -44.537  60.376  43.871  1.00 51.07           N  
ATOM   1119  CA  LEU A 580     -45.701  61.160  43.475  1.00 51.43           C  
ATOM   1120  C   LEU A 580     -45.369  62.630  43.145  1.00 51.57           C  
ATOM   1121  O   LEU A 580     -46.112  63.295  42.386  1.00 51.82           O  
ATOM   1122  CB  LEU A 580     -46.793  61.066  44.540  1.00 51.50           C  
ATOM   1123  CG  LEU A 580     -47.222  59.632  44.910  1.00 52.26           C  
ATOM   1124  CD1 LEU A 580     -48.636  59.662  45.520  1.00 52.37           C  
ATOM   1125  CD2 LEU A 580     -47.155  58.639  43.732  1.00 50.69           C  
ATOM   1126  N   GLU A 581     -44.281  63.152  43.710  1.00 51.11           N  
ATOM   1127  CA  GLU A 581     -43.828  64.476  43.323  1.00 50.83           C  
ATOM   1128  C   GLU A 581     -42.925  64.298  42.102  1.00 50.12           C  
ATOM   1129  O   GLU A 581     -41.714  64.073  42.241  1.00 50.78           O  
ATOM   1130  CB  GLU A 581     -43.097  65.180  44.467  1.00 51.03           C  
ATOM   1131  CG  GLU A 581     -42.973  66.695  44.251  1.00 52.21           C  
ATOM   1132  CD  GLU A 581     -41.894  67.348  45.106  1.00 54.49           C  
ATOM   1133  OE1 GLU A 581     -41.214  66.625  45.881  1.00 55.60           O  
ATOM   1134  OE2 GLU A 581     -41.722  68.588  45.001  1.00 55.26           O  
ATOM   1135  N   THR A 582     -43.519  64.372  40.911  1.00 48.85           N  
ATOM   1136  CA  THR A 582     -42.782  64.120  39.666  1.00 47.81           C  
ATOM   1137  C   THR A 582     -42.034  65.356  39.161  1.00 46.82           C  
ATOM   1138  O   THR A 582     -41.148  65.237  38.325  1.00 47.64           O  
ATOM   1139  CB  THR A 582     -43.711  63.541  38.561  1.00 47.90           C  
ATOM   1140  OG1 THR A 582     -44.990  64.169  38.637  1.00 46.78           O  
ATOM   1141  CG2 THR A 582     -43.895  62.018  38.741  1.00 47.72           C  
ATOM   1142  N   SER A 583     -42.364  66.532  39.687  1.00 45.38           N  
ATOM   1143  CA  SER A 583     -41.621  67.757  39.378  1.00 44.31           C  
ATOM   1144  C   SER A 583     -40.511  68.059  40.397  1.00 43.09           C  
ATOM   1145  O   SER A 583     -39.928  69.153  40.390  1.00 42.71           O  
ATOM   1146  CB  SER A 583     -42.580  68.940  39.376  1.00 44.56           C  
ATOM   1147  OG  SER A 583     -43.011  69.207  40.706  1.00 44.65           O  
ATOM   1148  N   ARG A 584     -40.240  67.111  41.290  1.00 41.64           N  
ATOM   1149  CA  ARG A 584     -39.214  67.298  42.309  1.00 40.64           C  
ATOM   1150  C   ARG A 584     -37.877  67.516  41.652  1.00 39.02           C  
ATOM   1151  O   ARG A 584     -37.155  68.424  41.994  1.00 38.95           O  
ATOM   1152  CB  ARG A 584     -39.134  66.083  43.234  1.00 40.90           C  
ATOM   1153  CG  ARG A 584     -38.065  66.196  44.320  1.00 41.79           C  
ATOM   1154  CD  ARG A 584     -38.228  65.110  45.390  1.00 43.45           C  
ATOM   1155  NE  ARG A 584     -37.310  65.292  46.523  1.00 44.32           N  
ATOM   1156  CZ  ARG A 584     -37.473  66.176  47.509  1.00 43.18           C  
ATOM   1157  NH1 ARG A 584     -38.526  66.987  47.537  1.00 41.61           N  
ATOM   1158  NH2 ARG A 584     -36.571  66.240  48.480  1.00 43.81           N  
ATOM   1159  N   PHE A 585     -37.551  66.659  40.707  1.00 37.86           N  
ATOM   1160  CA  PHE A 585     -36.311  66.780  39.963  1.00 37.01           C  
ATOM   1161  C   PHE A 585     -36.322  68.053  39.115  1.00 36.83           C  
ATOM   1162  O   PHE A 585     -35.294  68.701  38.927  1.00 36.44           O  
ATOM   1163  CB  PHE A 585     -36.133  65.543  39.086  1.00 36.67           C  
ATOM   1164  CG  PHE A 585     -34.858  65.524  38.323  1.00 35.46           C  
ATOM   1165  CD1 PHE A 585     -33.659  65.262  38.972  1.00 33.30           C  
ATOM   1166  CD2 PHE A 585     -34.848  65.781  36.956  1.00 34.10           C  
ATOM   1167  CE1 PHE A 585     -32.478  65.245  38.277  1.00 32.44           C  
ATOM   1168  CE2 PHE A 585     -33.665  65.766  36.257  1.00 33.70           C  
ATOM   1169  CZ  PHE A 585     -32.471  65.491  36.923  1.00 32.92           C  
ATOM   1170  N   THR A 586     -37.501  68.404  38.613  1.00 36.95           N  
ATOM   1171  CA  THR A 586     -37.683  69.631  37.843  1.00 37.10           C  
ATOM   1172  C   THR A 586     -37.354  70.847  38.689  1.00 37.87           C  
ATOM   1173  O   THR A 586     -36.618  71.714  38.235  1.00 38.21           O  
ATOM   1174  CB  THR A 586     -39.111  69.733  37.276  1.00 36.71           C  
ATOM   1175  OG1 THR A 586     -39.375  68.560  36.497  1.00 36.70           O  
ATOM   1176  CG2 THR A 586     -39.268  70.949  36.416  1.00 35.37           C  
ATOM   1177  N   LYS A 587     -37.874  70.904  39.916  1.00 38.62           N  
ATOM   1178  CA  LYS A 587     -37.592  72.030  40.817  1.00 39.44           C  
ATOM   1179  C   LYS A 587     -36.100  72.189  41.121  1.00 39.51           C  
ATOM   1180  O   LYS A 587     -35.579  73.315  41.135  1.00 39.71           O  
ATOM   1181  CB  LYS A 587     -38.336  71.871  42.136  1.00 40.09           C  
ATOM   1182  CG  LYS A 587     -39.850  72.021  42.041  1.00 42.20           C  
ATOM   1183  CD  LYS A 587     -40.500  71.637  43.376  1.00 45.56           C  
ATOM   1184  CE  LYS A 587     -41.949  71.152  43.189  1.00 48.62           C  
ATOM   1185  NZ  LYS A 587     -42.714  70.965  44.492  1.00 50.60           N  
ATOM   1186  N   LEU A 588     -35.424  71.065  41.361  1.00 39.25           N  
ATOM   1187  CA  LEU A 588     -33.983  71.060  41.574  1.00 39.24           C  
ATOM   1188  C   LEU A 588     -33.220  71.599  40.377  1.00 39.09           C  
ATOM   1189  O   LEU A 588     -32.330  72.432  40.524  1.00 39.34           O  
ATOM   1190  CB  LEU A 588     -33.487  69.647  41.895  1.00 39.37           C  
ATOM   1191  CG  LEU A 588     -33.581  69.281  43.374  1.00 39.67           C  
ATOM   1192  CD1 LEU A 588     -33.378  67.779  43.586  1.00 39.25           C  
ATOM   1193  CD2 LEU A 588     -32.563  70.111  44.160  1.00 38.98           C  
ATOM   1194  N   LEU A 589     -33.547  71.106  39.193  1.00 38.98           N  
ATOM   1195  CA  LEU A 589     -32.950  71.637  37.971  1.00 39.22           C  
ATOM   1196  C   LEU A 589     -33.206  73.144  37.768  1.00 38.86           C  
ATOM   1197  O   LEU A 589     -32.439  73.808  37.075  1.00 38.34           O  
ATOM   1198  CB  LEU A 589     -33.447  70.866  36.732  1.00 39.55           C  
ATOM   1199  CG  LEU A 589     -32.909  69.449  36.516  1.00 40.26           C  
ATOM   1200  CD1 LEU A 589     -33.604  68.808  35.309  1.00 40.21           C  
ATOM   1201  CD2 LEU A 589     -31.409  69.469  36.338  1.00 39.63           C  
ATOM   1202  N   LEU A 590     -34.288  73.671  38.349  1.00 38.98           N  
ATOM   1203  CA  LEU A 590     -34.607  75.108  38.228  1.00 38.93           C  
ATOM   1204  C   LEU A 590     -33.737  75.982  39.132  1.00 38.67           C  
ATOM   1205  O   LEU A 590     -33.704  77.208  38.982  1.00 39.17           O  
ATOM   1206  CB  LEU A 590     -36.093  75.379  38.510  1.00 38.92           C  
ATOM   1207  CG  LEU A 590     -37.114  74.953  37.444  1.00 39.06           C  
ATOM   1208  CD1 LEU A 590     -38.506  75.273  37.978  1.00 39.21           C  
ATOM   1209  CD2 LEU A 590     -36.883  75.610  36.096  1.00 36.37           C  
ATOM   1210  N   LYS A 591     -33.022  75.360  40.062  1.00 38.31           N  
ATOM   1211  CA  LYS A 591     -32.091  76.090  40.906  1.00 37.84           C  
ATOM   1212  C   LYS A 591     -30.859  76.504  40.115  1.00 37.57           C  
ATOM   1213  O   LYS A 591     -30.134  77.377  40.539  1.00 37.87           O  
ATOM   1214  CB  LYS A 591     -31.694  75.243  42.104  1.00 37.53           C  
ATOM   1215  CG  LYS A 591     -32.879  74.788  42.954  1.00 38.38           C  
ATOM   1216  CD  LYS A 591     -33.529  75.933  43.735  1.00 38.82           C  
ATOM   1217  CE  LYS A 591     -34.937  75.587  44.168  1.00 39.12           C  
ATOM   1218  NZ  LYS A 591     -35.876  75.576  42.994  1.00 39.93           N  
ATOM   1219  N   LEU A 592     -30.629  75.898  38.959  1.00 37.41           N  
ATOM   1220  CA  LEU A 592     -29.405  76.148  38.221  1.00 37.65           C  
ATOM   1221  C   LEU A 592     -29.319  77.537  37.606  1.00 38.19           C  
ATOM   1222  O   LEU A 592     -28.279  78.169  37.732  1.00 38.18           O  
ATOM   1223  CB  LEU A 592     -29.179  75.084  37.151  1.00 37.45           C  
ATOM   1224  CG  LEU A 592     -28.948  73.649  37.631  1.00 37.93           C  
ATOM   1225  CD1 LEU A 592     -28.636  72.780  36.405  1.00 40.22           C  
ATOM   1226  CD2 LEU A 592     -27.841  73.518  38.677  1.00 36.85           C  
ATOM   1227  N   PRO A 593     -30.391  78.008  36.922  1.00 39.20           N  
ATOM   1228  CA  PRO A 593     -30.398  79.381  36.412  1.00 39.39           C  
ATOM   1229  C   PRO A 593     -30.253  80.384  37.533  1.00 39.91           C  
ATOM   1230  O   PRO A 593     -29.530  81.377  37.364  1.00 40.60           O  
ATOM   1231  CB  PRO A 593     -31.787  79.535  35.770  1.00 39.50           C  
ATOM   1232  CG  PRO A 593     -32.287  78.175  35.536  1.00 39.57           C  
ATOM   1233  CD  PRO A 593     -31.643  77.301  36.576  1.00 39.61           C  
ATOM   1234  N   ASP A 594     -30.934  80.124  38.656  1.00 39.91           N  
ATOM   1235  CA  ASP A 594     -30.830  80.967  39.855  1.00 40.25           C  
ATOM   1236  C   ASP A 594     -29.373  81.098  40.299  1.00 40.08           C  
ATOM   1237  O   ASP A 594     -28.892  82.210  40.603  1.00 40.54           O  
ATOM   1238  CB  ASP A 594     -31.634  80.389  41.029  1.00 40.34           C  
ATOM   1239  CG  ASP A 594     -33.112  80.242  40.725  1.00 41.69           C  
ATOM   1240  OD1 ASP A 594     -33.605  80.923  39.798  1.00 44.39           O  
ATOM   1241  OD2 ASP A 594     -33.788  79.454  41.430  1.00 43.26           O  
ATOM   1242  N   LEU A 595     -28.679  79.962  40.342  1.00 39.33           N  
ATOM   1243  CA  LEU A 595     -27.291  79.940  40.785  1.00 38.97           C  
ATOM   1244  C   LEU A 595     -26.415  80.699  39.807  1.00 39.23           C  
ATOM   1245  O   LEU A 595     -25.508  81.400  40.217  1.00 39.04           O  
ATOM   1246  CB  LEU A 595     -26.792  78.507  40.983  1.00 38.39           C  
ATOM   1247  CG  LEU A 595     -27.237  77.875  42.303  1.00 37.21           C  
ATOM   1248  CD1 LEU A 595     -26.995  76.388  42.269  1.00 35.95           C  
ATOM   1249  CD2 LEU A 595     -26.514  78.506  43.475  1.00 35.85           C  
ATOM   1250  N   ARG A 596     -26.704  80.583  38.519  1.00 39.70           N  
ATOM   1251  CA  ARG A 596     -25.971  81.346  37.518  1.00 40.36           C  
ATOM   1252  C   ARG A 596     -26.165  82.844  37.747  1.00 40.81           C  
ATOM   1253  O   ARG A 596     -25.226  83.635  37.598  1.00 40.59           O  
ATOM   1254  CB  ARG A 596     -26.453  80.997  36.121  1.00 40.53           C  
ATOM   1255  CG  ARG A 596     -25.343  80.913  35.121  1.00 41.80           C  
ATOM   1256  CD  ARG A 596     -24.589  79.582  35.215  1.00 43.32           C  
ATOM   1257  NE  ARG A 596     -24.273  79.080  33.875  1.00 44.98           N  
ATOM   1258  CZ  ARG A 596     -24.182  77.796  33.544  1.00 47.75           C  
ATOM   1259  NH1 ARG A 596     -24.386  76.851  34.452  1.00 49.42           N  
ATOM   1260  NH2 ARG A 596     -23.894  77.443  32.293  1.00 49.39           N  
ATOM   1261  N   THR A 597     -27.383  83.237  38.120  1.00 41.06           N  
ATOM   1262  CA  THR A 597     -27.663  84.644  38.364  1.00 41.40           C  
ATOM   1263  C   THR A 597     -26.955  85.132  39.617  1.00 41.44           C  
ATOM   1264  O   THR A 597     -26.286  86.153  39.565  1.00 41.79           O  
ATOM   1265  CB  THR A 597     -29.181  84.953  38.431  1.00 41.58           C  
ATOM   1266  OG1 THR A 597     -29.737  84.866  37.118  1.00 42.93           O  
ATOM   1267  CG2 THR A 597     -29.438  86.347  38.940  1.00 40.33           C  
ATOM   1268  N   LEU A 598     -27.094  84.422  40.732  1.00 41.80           N  
ATOM   1269  CA  LEU A 598     -26.390  84.809  41.963  1.00 42.03           C  
ATOM   1270  C   LEU A 598     -24.901  84.943  41.633  1.00 42.67           C  
ATOM   1271  O   LEU A 598     -24.239  85.912  42.010  1.00 42.10           O  
ATOM   1272  CB  LEU A 598     -26.588  83.776  43.074  1.00 41.90           C  
ATOM   1273  CG  LEU A 598     -27.979  83.558  43.681  1.00 41.77           C  
ATOM   1274  CD1 LEU A 598     -28.036  82.272  44.517  1.00 41.38           C  
ATOM   1275  CD2 LEU A 598     -28.338  84.721  44.543  1.00 41.49           C  
ATOM   1276  N   ASN A 599     -24.394  83.968  40.886  1.00 43.70           N  
ATOM   1277  CA  ASN A 599     -23.007  83.965  40.476  1.00 44.51           C  
ATOM   1278  C   ASN A 599     -22.662  85.228  39.683  1.00 45.74           C  
ATOM   1279  O   ASN A 599     -21.735  85.963  40.042  1.00 45.77           O  
ATOM   1280  CB  ASN A 599     -22.690  82.711  39.663  1.00 44.22           C  
ATOM   1281  CG  ASN A 599     -21.240  82.620  39.298  1.00 43.65           C  
ATOM   1282  OD1 ASN A 599     -20.400  83.261  39.909  1.00 42.95           O  
ATOM   1283  ND2 ASN A 599     -20.934  81.826  38.300  1.00 44.54           N  
ATOM   1284  N   ASN A 600     -23.426  85.488  38.624  1.00 47.02           N  
ATOM   1285  CA  ASN A 600     -23.139  86.607  37.730  1.00 47.83           C  
ATOM   1286  C   ASN A 600     -23.236  87.973  38.456  1.00 48.47           C  
ATOM   1287  O   ASN A 600     -22.549  88.922  38.082  1.00 48.88           O  
ATOM   1288  CB  ASN A 600     -24.025  86.522  36.458  1.00 47.94           C  
ATOM   1289  CG  ASN A 600     -23.669  85.283  35.531  1.00 48.81           C  
ATOM   1290  OD1 ASN A 600     -22.572  84.692  35.624  1.00 48.31           O  
ATOM   1291  ND2 ASN A 600     -24.607  84.908  34.645  1.00 46.29           N  
ATOM   1292  N   MET A 601     -24.023  88.050  39.528  1.00 48.98           N  
ATOM   1293  CA  MET A 601     -24.175  89.292  40.300  1.00 49.67           C  
ATOM   1294  C   MET A 601     -23.208  89.508  41.475  1.00 49.23           C  
ATOM   1295  O   MET A 601     -22.835  90.645  41.765  1.00 49.34           O  
ATOM   1296  CB  MET A 601     -25.582  89.361  40.872  1.00 50.30           C  
ATOM   1297  CG  MET A 601     -26.634  89.349  39.819  1.00 53.39           C  
ATOM   1298  SD  MET A 601     -28.234  89.774  40.511  1.00 60.73           S  
ATOM   1299  CE  MET A 601     -28.230  91.570  40.251  1.00 61.44           C  
ATOM   1300  N   HIS A 602     -22.828  88.436  42.165  1.00 48.61           N  
ATOM   1301  CA  HIS A 602     -22.131  88.569  43.441  1.00 48.25           C  
ATOM   1302  C   HIS A 602     -20.695  88.052  43.495  1.00 48.30           C  
ATOM   1303  O   HIS A 602     -19.991  88.334  44.462  1.00 48.67           O  
ATOM   1304  CB  HIS A 602     -22.944  87.894  44.533  1.00 48.00           C  
ATOM   1305  CG  HIS A 602     -24.307  88.467  44.688  1.00 47.67           C  
ATOM   1306  ND1 HIS A 602     -24.522  89.806  44.914  1.00 48.13           N  
ATOM   1307  CD2 HIS A 602     -25.527  87.889  44.644  1.00 47.97           C  
ATOM   1308  CE1 HIS A 602     -25.819  90.029  45.011  1.00 48.38           C  
ATOM   1309  NE2 HIS A 602     -26.451  88.882  44.851  1.00 48.06           N  
ATOM   1310  N   SER A 603     -20.238  87.320  42.485  1.00 48.25           N  
ATOM   1311  CA  SER A 603     -18.875  86.783  42.519  1.00 48.30           C  
ATOM   1312  C   SER A 603     -17.828  87.889  42.493  1.00 48.63           C  
ATOM   1313  O   SER A 603     -16.662  87.651  42.793  1.00 48.86           O  
ATOM   1314  CB  SER A 603     -18.642  85.829  41.355  1.00 48.19           C  
ATOM   1315  OG  SER A 603     -19.026  86.428  40.143  1.00 47.46           O  
ATOM   1316  N   GLU A 604     -18.255  89.091  42.129  1.00 48.95           N  
ATOM   1317  CA  GLU A 604     -17.379  90.237  42.082  1.00 49.47           C  
ATOM   1318  C   GLU A 604     -17.348  91.008  43.415  1.00 49.04           C  
ATOM   1319  O   GLU A 604     -16.630  92.006  43.522  1.00 49.32           O  
ATOM   1320  CB  GLU A 604     -17.795  91.159  40.928  1.00 50.03           C  
ATOM   1321  CG  GLU A 604     -16.650  91.534  39.979  1.00 52.77           C  
ATOM   1322  CD  GLU A 604     -16.243  90.381  39.054  1.00 57.21           C  
ATOM   1323  OE1 GLU A 604     -16.402  90.538  37.816  1.00 60.10           O  
ATOM   1324  OE2 GLU A 604     -15.783  89.317  39.554  1.00 59.87           O  
ATOM   1325  N   LYS A 605     -18.100  90.561  44.426  1.00 48.37           N  
ATOM   1326  CA  LYS A 605     -18.011  91.170  45.766  1.00 47.86           C  
ATOM   1327  C   LYS A 605     -16.565  91.159  46.274  1.00 47.02           C  
ATOM   1328  O   LYS A 605     -15.844  90.188  46.066  1.00 46.60           O  
ATOM   1329  CB  LYS A 605     -18.901  90.442  46.787  1.00 47.89           C  
ATOM   1330  CG  LYS A 605     -20.400  90.696  46.652  1.00 48.97           C  
ATOM   1331  CD  LYS A 605     -20.765  92.161  46.422  1.00 50.44           C  
ATOM   1332  CE  LYS A 605     -22.273  92.399  46.580  1.00 51.15           C  
ATOM   1333  NZ  LYS A 605     -22.687  92.351  48.025  1.00 51.45           N  
ATOM   1334  N   LEU A 606     -16.165  92.243  46.942  1.00 46.34           N  
ATOM   1335  CA  LEU A 606     -14.802  92.393  47.457  1.00 45.66           C  
ATOM   1336  C   LEU A 606     -14.620  91.647  48.753  1.00 45.40           C  
ATOM   1337  O   LEU A 606     -15.447  91.742  49.640  1.00 45.44           O  
ATOM   1338  CB  LEU A 606     -14.454  93.862  47.707  1.00 45.35           C  
ATOM   1339  CG  LEU A 606     -14.124  94.734  46.495  1.00 44.90           C  
ATOM   1340  CD1 LEU A 606     -13.817  96.133  46.999  1.00 44.52           C  
ATOM   1341  CD2 LEU A 606     -12.972  94.182  45.660  1.00 42.79           C  
ATOM   1342  N   LEU A 607     -13.529  90.904  48.844  1.00 45.29           N  
ATOM   1343  CA  LEU A 607     -13.043  90.406  50.106  1.00 45.45           C  
ATOM   1344  C   LEU A 607     -11.907  91.301  50.582  1.00 45.92           C  
ATOM   1345  O   LEU A 607     -11.407  92.141  49.842  1.00 45.72           O  
ATOM   1346  CB  LEU A 607     -12.561  88.965  49.946  1.00 45.38           C  
ATOM   1347  CG  LEU A 607     -13.645  87.962  49.541  1.00 44.91           C  
ATOM   1348  CD1 LEU A 607     -13.136  86.554  49.795  1.00 44.40           C  
ATOM   1349  CD2 LEU A 607     -14.959  88.204  50.292  1.00 43.79           C  
ATOM   1350  N   SER A 608     -11.505  91.115  51.827  1.00 46.74           N  
ATOM   1351  CA  SER A 608     -10.477  91.945  52.434  1.00 47.57           C  
ATOM   1352  C   SER A 608      -9.567  91.113  53.313  1.00 48.24           C  
ATOM   1353  O   SER A 608     -10.047  90.360  54.162  1.00 48.40           O  
ATOM   1354  CB  SER A 608     -11.132  93.023  53.283  1.00 47.63           C  
ATOM   1355  OG  SER A 608     -10.176  93.962  53.714  1.00 48.21           O  
ATOM   1356  N   PHE A 609      -8.260  91.249  53.120  1.00 49.12           N  
ATOM   1357  CA  PHE A 609      -7.290  90.503  53.916  1.00 50.05           C  
ATOM   1358  C   PHE A 609      -6.213  91.439  54.411  1.00 51.15           C  
ATOM   1359  O   PHE A 609      -5.582  92.120  53.614  1.00 51.29           O  
ATOM   1360  CB  PHE A 609      -6.660  89.378  53.089  1.00 50.00           C  
ATOM   1361  CG  PHE A 609      -7.654  88.371  52.605  1.00 49.57           C  
ATOM   1362  CD1 PHE A 609      -8.061  87.340  53.430  1.00 48.44           C  
ATOM   1363  CD2 PHE A 609      -8.219  88.482  51.332  1.00 49.62           C  
ATOM   1364  CE1 PHE A 609      -9.001  86.419  52.997  1.00 48.70           C  
ATOM   1365  CE2 PHE A 609      -9.163  87.565  50.890  1.00 49.17           C  
ATOM   1366  CZ  PHE A 609      -9.552  86.528  51.725  1.00 48.96           C  
ATOM   1367  N   ARG A 610      -5.999  91.460  55.722  1.00 52.69           N  
ATOM   1368  CA  ARG A 610      -4.981  92.318  56.310  1.00 54.17           C  
ATOM   1369  C   ARG A 610      -3.609  91.893  55.807  1.00 54.91           C  
ATOM   1370  O   ARG A 610      -3.183  90.766  56.036  1.00 55.31           O  
ATOM   1371  CB  ARG A 610      -5.024  92.271  57.846  1.00 54.59           C  
ATOM   1372  CG  ARG A 610      -4.275  93.442  58.531  1.00 55.91           C  
ATOM   1373  CD  ARG A 610      -4.381  93.371  60.053  1.00 57.57           C  
ATOM   1374  NE  ARG A 610      -5.770  93.342  60.518  1.00 58.61           N  
ATOM   1375  N   VAL A 611      -2.944  92.793  55.087  1.00 55.80           N  
ATOM   1376  CA  VAL A 611      -1.604  92.553  54.606  1.00 56.50           C  
ATOM   1377  C   VAL A 611      -0.671  92.787  55.784  1.00 57.31           C  
ATOM   1378  O   VAL A 611      -0.045  91.846  56.300  1.00 58.06           O  
ATOM   1379  CB  VAL A 611      -1.237  93.498  53.453  1.00 56.51           C  
ATOM   1380  CG1 VAL A 611       0.280  93.513  53.229  1.00 56.77           C  
ATOM   1381  CG2 VAL A 611      -1.971  93.094  52.185  1.00 56.69           C  
TER    1382      VAL A 611                                                      
ATOM   1383  N   THR B2045      -2.209  97.568  56.519  1.00 48.84           N  
ATOM   1384  CA  THR B2045      -2.844  97.696  55.175  1.00 48.64           C  
ATOM   1385  C   THR B2045      -3.631  96.431  54.842  1.00 48.20           C  
ATOM   1386  O   THR B2045      -3.599  95.450  55.589  1.00 48.04           O  
ATOM   1387  CB  THR B2045      -1.796  97.997  54.070  1.00 48.74           C  
ATOM   1388  OG1 THR B2045      -0.731  97.040  54.134  1.00 49.41           O  
ATOM   1389  CG2 THR B2045      -1.212  99.405  54.248  1.00 49.18           C  
ATOM   1390  N   HIS B2046      -4.359  96.475  53.733  1.00 47.88           N  
ATOM   1391  CA  HIS B2046      -5.213  95.370  53.330  1.00 47.62           C  
ATOM   1392  C   HIS B2046      -5.082  95.102  51.861  1.00 47.33           C  
ATOM   1393  O   HIS B2046      -4.834  96.012  51.072  1.00 47.00           O  
ATOM   1394  CB  HIS B2046      -6.680  95.671  53.619  1.00 47.67           C  
ATOM   1395  CG  HIS B2046      -7.014  95.668  55.070  1.00 48.39           C  
ATOM   1396  ND1 HIS B2046      -6.511  96.603  55.948  1.00 49.53           N  
ATOM   1397  CD2 HIS B2046      -7.799  94.845  55.802  1.00 48.97           C  
ATOM   1398  CE1 HIS B2046      -6.971  96.354  57.162  1.00 49.82           C  
ATOM   1399  NE2 HIS B2046      -7.756  95.293  57.101  1.00 48.97           N  
ATOM   1400  N   ARG B2047      -5.257  93.829  51.520  1.00 47.15           N  
ATOM   1401  CA  ARG B2047      -5.479  93.387  50.154  1.00 47.05           C  
ATOM   1402  C   ARG B2047      -6.988  93.276  49.910  1.00 45.87           C  
ATOM   1403  O   ARG B2047      -7.699  92.550  50.630  1.00 45.60           O  
ATOM   1404  CB  ARG B2047      -4.831  92.012  49.939  1.00 47.77           C  
ATOM   1405  CG  ARG B2047      -3.507  92.018  49.191  1.00 50.64           C  
ATOM   1406  CD  ARG B2047      -2.817  90.636  49.235  1.00 54.50           C  
ATOM   1407  NE  ARG B2047      -3.746  89.496  49.328  1.00 57.80           N  
ATOM   1408  CZ  ARG B2047      -4.557  89.068  48.344  1.00 61.01           C  
ATOM   1409  NH1 ARG B2047      -4.595  89.701  47.162  1.00 61.66           N  
ATOM   1410  NH2 ARG B2047      -5.352  87.999  48.541  1.00 61.07           N  
ATOM   1411  N   LEU B2048      -7.473  94.000  48.905  1.00 44.69           N  
ATOM   1412  CA  LEU B2048      -8.875  93.905  48.481  1.00 43.94           C  
ATOM   1413  C   LEU B2048      -8.935  93.103  47.197  1.00 43.36           C  
ATOM   1414  O   LEU B2048      -8.318  93.458  46.189  1.00 43.59           O  
ATOM   1415  CB  LEU B2048      -9.508  95.284  48.291  1.00 43.79           C  
ATOM   1416  CG  LEU B2048      -9.542  96.163  49.554  1.00 43.53           C  
ATOM   1417  CD1 LEU B2048      -9.908  97.580  49.192  1.00 42.64           C  
ATOM   1418  CD2 LEU B2048     -10.488  95.609  50.604  1.00 42.76           C  
ATOM   1419  N   ILE B2049      -9.671  91.997  47.259  1.00 42.75           N  
ATOM   1420  CA  ILE B2049      -9.707  91.000  46.187  1.00 41.49           C  
ATOM   1421  C   ILE B2049     -11.148  90.527  46.017  1.00 40.71           C  
ATOM   1422  O   ILE B2049     -11.840  90.268  46.999  1.00 40.68           O  
ATOM   1423  CB  ILE B2049      -8.717  89.820  46.493  1.00 41.24           C  
ATOM   1424  CG1 ILE B2049      -8.575  88.888  45.282  1.00 41.15           C  
ATOM   1425  CG2 ILE B2049      -9.123  89.067  47.757  1.00 40.63           C  
ATOM   1426  CD1 ILE B2049      -7.403  87.903  45.377  1.00 40.56           C  
ATOM   1427  N   THR B2050     -11.614  90.453  44.774  1.00 40.01           N  
ATOM   1428  CA  THR B2050     -12.959  89.947  44.505  1.00 39.28           C  
ATOM   1429  C   THR B2050     -13.091  88.492  44.913  1.00 39.04           C  
ATOM   1430  O   THR B2050     -12.127  87.725  44.886  1.00 38.39           O  
ATOM   1431  CB  THR B2050     -13.361  90.079  43.040  1.00 39.08           C  
ATOM   1432  OG1 THR B2050     -12.441  89.337  42.227  1.00 38.94           O  
ATOM   1433  CG2 THR B2050     -13.388  91.547  42.632  1.00 37.52           C  
ATOM   1434  N   LEU B2051     -14.303  88.139  45.310  1.00 39.27           N  
ATOM   1435  CA  LEU B2051     -14.618  86.794  45.761  1.00 39.79           C  
ATOM   1436  C   LEU B2051     -14.278  85.794  44.664  1.00 39.81           C  
ATOM   1437  O   LEU B2051     -13.747  84.727  44.932  1.00 39.71           O  
ATOM   1438  CB  LEU B2051     -16.091  86.730  46.144  1.00 39.98           C  
ATOM   1439  CG  LEU B2051     -16.726  85.413  46.577  1.00 41.37           C  
ATOM   1440  CD1 LEU B2051     -15.812  84.524  47.442  1.00 41.28           C  
ATOM   1441  CD2 LEU B2051     -17.994  85.806  47.331  1.00 42.05           C  
ATOM   1442  N   ALA B2052     -14.546  86.172  43.417  1.00 40.17           N  
ATOM   1443  CA  ALA B2052     -14.167  85.354  42.265  1.00 40.25           C  
ATOM   1444  C   ALA B2052     -12.635  85.164  42.155  1.00 40.44           C  
ATOM   1445  O   ALA B2052     -12.154  84.045  41.949  1.00 40.62           O  
ATOM   1446  CB  ALA B2052     -14.735  85.965  40.983  1.00 39.97           C  
ATOM   1447  N   ASP B2053     -11.869  86.247  42.294  1.00 40.59           N  
ATOM   1448  CA  ASP B2053     -10.414  86.162  42.136  1.00 40.61           C  
ATOM   1449  C   ASP B2053      -9.786  85.384  43.284  1.00 40.14           C  
ATOM   1450  O   ASP B2053      -8.821  84.660  43.069  1.00 40.68           O  
ATOM   1451  CB  ASP B2053      -9.771  87.550  42.004  1.00 41.07           C  
ATOM   1452  CG  ASP B2053     -10.074  88.228  40.655  1.00 42.95           C  
ATOM   1453  OD1 ASP B2053     -10.369  87.517  39.658  1.00 45.54           O  
ATOM   1454  OD2 ASP B2053     -10.011  89.485  40.592  1.00 44.78           O  
ATOM   1455  N   HIS B2054     -10.342  85.505  44.487  1.00 39.50           N  
ATOM   1456  CA  HIS B2054      -9.882  84.712  45.635  1.00 39.11           C  
ATOM   1457  C   HIS B2054     -10.085  83.212  45.392  1.00 39.48           C  
ATOM   1458  O   HIS B2054      -9.231  82.386  45.744  1.00 39.45           O  
ATOM   1459  CB  HIS B2054     -10.609  85.159  46.914  1.00 38.80           C  
ATOM   1460  CG  HIS B2054     -10.095  84.516  48.161  1.00 37.68           C  
ATOM   1461  ND1 HIS B2054      -8.758  84.511  48.499  1.00 36.17           N  
ATOM   1462  CD2 HIS B2054     -10.738  83.858  49.156  1.00 36.80           C  
ATOM   1463  CE1 HIS B2054      -8.598  83.862  49.640  1.00 36.56           C  
ATOM   1464  NE2 HIS B2054      -9.785  83.464  50.065  1.00 36.15           N  
ATOM   1465  N   ILE B2055     -11.218  82.872  44.776  1.00 39.95           N  
ATOM   1466  CA  ILE B2055     -11.553  81.491  44.481  1.00 39.95           C  
ATOM   1467  C   ILE B2055     -10.545  80.895  43.511  1.00 40.61           C  
ATOM   1468  O   ILE B2055     -10.049  79.802  43.749  1.00 40.85           O  
ATOM   1469  CB  ILE B2055     -13.016  81.354  43.957  1.00 39.88           C  
ATOM   1470  CG1 ILE B2055     -13.996  81.497  45.125  1.00 39.58           C  
ATOM   1471  CG2 ILE B2055     -13.256  80.000  43.258  1.00 38.80           C  
ATOM   1472  CD1 ILE B2055     -15.456  81.524  44.723  1.00 38.36           C  
ATOM   1473  N   CYS B2056     -10.219  81.603  42.439  1.00 41.25           N  
ATOM   1474  CA  CYS B2056      -9.242  81.077  41.474  1.00 42.62           C  
ATOM   1475  C   CYS B2056      -7.849  80.907  42.074  1.00 42.51           C  
ATOM   1476  O   CYS B2056      -7.168  79.912  41.813  1.00 42.24           O  
ATOM   1477  CB  CYS B2056      -9.177  81.962  40.226  1.00 42.91           C  
ATOM   1478  SG  CYS B2056     -10.820  82.167  39.459  1.00 47.05           S  
ATOM   1479  N   GLN B2057      -7.442  81.882  42.879  1.00 42.92           N  
ATOM   1480  CA  GLN B2057      -6.183  81.811  43.602  1.00 43.66           C  
ATOM   1481  C   GLN B2057      -6.110  80.561  44.469  1.00 43.58           C  
ATOM   1482  O   GLN B2057      -5.148  79.793  44.395  1.00 44.20           O  
ATOM   1483  CB  GLN B2057      -5.971  83.076  44.452  1.00 44.28           C  
ATOM   1484  CG  GLN B2057      -5.615  84.334  43.600  1.00 46.95           C  
ATOM   1485  CD  GLN B2057      -5.052  85.528  44.408  1.00 50.10           C  
ATOM   1486  OE1 GLN B2057      -4.981  85.498  45.649  1.00 52.70           O  
ATOM   1487  NE2 GLN B2057      -4.659  86.586  43.691  1.00 50.36           N  
ATOM   1488  N   ILE B2058      -7.132  80.335  45.278  1.00 43.42           N  
ATOM   1489  CA  ILE B2058      -7.117  79.186  46.174  1.00 43.35           C  
ATOM   1490  C   ILE B2058      -7.122  77.867  45.416  1.00 43.34           C  
ATOM   1491  O   ILE B2058      -6.450  76.929  45.818  1.00 43.62           O  
ATOM   1492  CB  ILE B2058      -8.286  79.245  47.145  1.00 43.41           C  
ATOM   1493  CG1 ILE B2058      -8.068  80.404  48.099  1.00 43.50           C  
ATOM   1494  CG2 ILE B2058      -8.429  77.932  47.923  1.00 42.85           C  
ATOM   1495  CD1 ILE B2058      -9.287  80.752  48.816  1.00 45.51           C  
ATOM   1496  N   ILE B2059      -7.872  77.799  44.320  1.00 43.45           N  
ATOM   1497  CA  ILE B2059      -7.884  76.603  43.467  1.00 43.52           C  
ATOM   1498  C   ILE B2059      -6.502  76.375  42.842  1.00 43.85           C  
ATOM   1499  O   ILE B2059      -5.982  75.255  42.840  1.00 43.04           O  
ATOM   1500  CB  ILE B2059      -8.927  76.722  42.330  1.00 43.33           C  
ATOM   1501  CG1 ILE B2059     -10.346  76.702  42.912  1.00 42.93           C  
ATOM   1502  CG2 ILE B2059      -8.721  75.611  41.297  1.00 41.81           C  
ATOM   1503  CD1 ILE B2059     -11.353  77.473  42.075  1.00 42.16           C  
ATOM   1504  N   THR B2060      -5.924  77.458  42.328  1.00 44.40           N  
ATOM   1505  CA  THR B2060      -4.615  77.409  41.712  1.00 45.02           C  
ATOM   1506  C   THR B2060      -3.549  76.977  42.700  1.00 45.90           C  
ATOM   1507  O   THR B2060      -2.777  76.059  42.424  1.00 45.77           O  
ATOM   1508  CB  THR B2060      -4.220  78.763  41.147  1.00 44.93           C  
ATOM   1509  OG1 THR B2060      -5.205  79.176  40.198  1.00 44.65           O  
ATOM   1510  CG2 THR B2060      -2.860  78.664  40.470  1.00 44.29           C  
ATOM   1511  N   GLN B2061      -3.509  77.644  43.846  1.00 47.09           N  
ATOM   1512  CA  GLN B2061      -2.572  77.279  44.893  1.00 48.35           C  
ATOM   1513  C   GLN B2061      -2.786  75.829  45.345  1.00 49.45           C  
ATOM   1514  O   GLN B2061      -1.829  75.107  45.592  1.00 49.97           O  
ATOM   1515  CB  GLN B2061      -2.689  78.241  46.085  1.00 48.48           C  
ATOM   1516  N   ASP B2062      -4.036  75.400  45.442  1.00 50.80           N  
ATOM   1517  CA  ASP B2062      -4.336  74.055  45.915  1.00 52.17           C  
ATOM   1518  C   ASP B2062      -3.856  72.993  44.917  1.00 52.86           C  
ATOM   1519  O   ASP B2062      -3.379  71.930  45.315  1.00 53.48           O  
ATOM   1520  CB  ASP B2062      -5.838  73.923  46.183  1.00 52.51           C  
ATOM   1521  CG  ASP B2062      -6.216  72.603  46.854  1.00 54.19           C  
ATOM   1522  OD1 ASP B2062      -7.039  72.640  47.809  1.00 55.99           O  
ATOM   1523  OD2 ASP B2062      -5.713  71.532  46.422  1.00 56.25           O  
ATOM   1524  N   PHE B2063      -3.988  73.269  43.622  1.00 53.52           N  
ATOM   1525  CA  PHE B2063      -3.543  72.318  42.592  1.00 53.79           C  
ATOM   1526  C   PHE B2063      -2.024  72.307  42.390  1.00 54.27           C  
ATOM   1527  O   PHE B2063      -1.486  71.315  41.912  1.00 54.32           O  
ATOM   1528  CB  PHE B2063      -4.270  72.570  41.266  1.00 53.54           C  
ATOM   1529  CG  PHE B2063      -5.531  71.774  41.120  1.00 53.96           C  
ATOM   1530  CD1 PHE B2063      -6.678  72.126  41.818  1.00 54.56           C  
ATOM   1531  CD2 PHE B2063      -5.572  70.647  40.299  1.00 54.49           C  
ATOM   1532  CE1 PHE B2063      -7.850  71.375  41.684  1.00 54.57           C  
ATOM   1533  CE2 PHE B2063      -6.738  69.895  40.164  1.00 54.40           C  
ATOM   1534  CZ  PHE B2063      -7.876  70.258  40.856  1.00 53.92           C  
ATOM   1535  N   ALA B2064      -1.341  73.395  42.762  1.00 55.06           N  
ATOM   1536  CA  ALA B2064       0.133  73.471  42.692  1.00 55.62           C  
ATOM   1537  C   ALA B2064       0.861  72.839  43.890  1.00 56.51           C  
ATOM   1538  O   ALA B2064       2.088  72.715  43.864  1.00 56.64           O  
ATOM   1539  CB  ALA B2064       0.596  74.921  42.515  1.00 55.15           C  
ATOM   1540  N   ARG B2065       0.131  72.433  44.933  1.00 57.44           N  
ATOM   1541  CA  ARG B2065       0.778  71.892  46.139  1.00 58.07           C  
ATOM   1542  C   ARG B2065       1.112  70.409  45.989  1.00 58.26           C  
ATOM   1543  CB  ARG B2065      -0.076  72.138  47.388  1.00 58.35           C  
ATOM   1544  CG  ARG B2065      -1.366  71.357  47.455  1.00 59.56           C  
ATOM   1545  CD  ARG B2065      -2.048  71.569  48.795  1.00 61.27           C  
ATOM   1546  NE  ARG B2065      -3.479  71.227  48.796  1.00 63.03           N  
ATOM   1547  CZ  ARG B2065      -3.988  69.992  48.766  1.00 64.15           C  
ATOM   1548  NH1 ARG B2065      -3.204  68.916  48.697  1.00 64.90           N  
ATOM   1549  NH2 ARG B2065      -5.307  69.828  48.792  1.00 65.06           N  
ATOM   1550  OXT ARG B2065       2.252  70.048  45.687  1.00 58.53           O  
TER    1551      ARG B2065                                                      
HETATM 1552  O   HOH A   1     -33.620  71.404  50.832  1.00 35.33           O  
HETATM 1553  O   HOH A   2     -42.277  68.946  35.837  1.00 25.95           O  
HETATM 1554  O   HOH A   4     -32.019  60.105  49.934  1.00 38.61           O  
HETATM 1555  O   HOH A   5     -11.158  66.708  30.381  1.00 39.55           O  
HETATM 1556  O   HOH A   6     -17.030  97.145  53.175  1.00 54.28           O  
HETATM 1557  O   HOH A   7     -23.145  59.332  31.054  1.00 48.96           O  
HETATM 1558  O   HOH A   8      -5.450  69.530  44.265  1.00 54.71           O  
HETATM 1559  O   HOH A   9     -37.229  63.408  49.241  1.00 50.80           O  
HETATM 1560  O   HOH A  10     -29.805  61.021  53.519  1.00 47.82           O  
HETATM 1561  O   HOH A  11     -27.025  82.167  53.763  1.00 52.92           O  
HETATM 1562  O   HOH A  12     -13.821  71.385  24.244  1.00 60.97           O  
HETATM 1563  O   HOH A  13     -25.590  87.233  62.781  1.00 50.54           O  
HETATM 1564  O   HOH A  14     -20.420  72.048  32.803  1.00 51.46           O  
HETATM 1565  O   HOH A  16     -23.360  81.367  60.543  1.00 63.83           O  
HETATM 1566  O   HOH A  17     -24.901  83.305  60.208  1.00 46.42           O  
HETATM 1567  O   HOH A  19     -15.510  78.385  32.632  1.00 54.86           O  
HETATM 1568  O   HOH A  20     -16.094  59.530  50.101  1.00 52.23           O  
HETATM 1569  O   HOH A  21     -27.888  89.917  60.177  1.00 54.30           O  
HETATM 1570  O   HOH A  22     -20.762  79.566  35.347  1.00 60.43           O  
HETATM 1571  O   HOH A  23      -6.310  62.628  38.211  1.00 64.17           O  
HETATM 1572  O   HOH A  24      -8.871  82.036  34.973  1.00 44.74           O  
HETATM 1573  O   HOH A  26     -26.326  62.539  56.771  1.00 64.39           O  
HETATM 1574  O   HOH A  27     -32.857  82.220  65.187  1.00 64.88           O  
HETATM 1575  O   HOH A  28      -8.076  68.587  47.689  1.00 59.39           O  
HETATM 1576  O   HOH A  29     -13.503  78.681  34.597  1.00 38.49           O  
HETATM 1577  O   HOH A  30     -23.416  86.385  64.085  1.00 58.45           O  
HETATM 1578  O   HOH A  31     -10.515  73.368  54.312  1.00 57.69           O  
HETATM 1579  O   HOH A  32     -31.469  55.790  48.646  1.00 47.51           O  
HETATM 1580  O   HOH A  33     -43.297  71.463  37.283  1.00 38.98           O  
HETATM 1581  O   HOH A  34     -25.923  76.961  37.399  1.00 43.98           O  
HETATM 1582  O   HOH A  35     -22.792  75.020  30.534  1.00 41.04           O  
HETATM 1583  O   HOH A  36     -29.803  67.665  54.735  1.00 70.53           O  
HETATM 1584  O   HOH A  37     -19.089  80.460  63.898  1.00 69.62           O  
HETATM 1585  O   HOH A  38     -29.602  90.996  46.087  1.00 59.39           O  
HETATM 1586  O   HOH A  40      -5.019  76.277  48.577  1.00 48.04           O  
HETATM 1587  O   HOH A  41     -12.745  75.188  62.790  1.00 67.74           O  
HETATM 1588  O   HOH A  43     -16.266  76.177  60.562  1.00 77.46           O  
HETATM 1589  O   HOH A  44     -25.023  69.984  54.995  1.00 49.01           O  
HETATM 1590  O   HOH A  45     -21.411  95.622  59.025  1.00 53.72           O  
HETATM 1591  O   HOH A  46     -41.326  69.935  47.606  1.00 55.62           O  
HETATM 1592  O   HOH A  47     -16.595  80.203  41.233  1.00 38.56           O  
HETATM 1593  O   HOH A  48     -19.221  53.330  47.937  1.00 54.50           O  
HETATM 1594  O   HOH A  49     -19.280  84.623  58.768  1.00 61.76           O  
HETATM 1595  O   HOH A  50     -19.058  59.058  36.419  1.00 57.41           O  
HETATM 1596  O   HOH A  51     -14.406  81.553  36.247  1.00 56.64           O  
HETATM 1597  O   HOH A  52     -31.117  84.275  41.094  1.00 53.88           O  
HETATM 1598  O   HOH A  53     -24.121  70.763  50.215  1.00 42.25           O  
HETATM 1599  O   HOH A  54     -17.453  71.347  57.293  1.00 65.91           O  
HETATM 1600  O   HOH A  55     -22.298  83.435  33.688  1.00 44.09           O  
HETATM 1601  O   HOH A  56     -16.381  83.010  37.953  1.00 44.65           O  
HETATM 1602  O   HOH A  58     -21.487  75.899  28.698  1.00 50.31           O  
HETATM 1603  O   HOH A  59     -19.809  84.355  65.442  1.00 50.42           O  
HETATM 1604  O   HOH A  60      -2.631  88.270  53.033  1.00 52.35           O  
HETATM 1605  O   HOH A  61       0.952  89.555  57.330  1.00 62.10           O  
HETATM 1606  O   HOH A  62     -22.862  67.269  55.987  1.00 67.73           O  
HETATM 1607  O   HOH B   3      -5.566  99.100  56.241  1.00 43.12           O  
HETATM 1608  O   HOH B  15      -9.690  91.411  42.616  1.00 39.99           O  
HETATM 1609  O   HOH B  18      -1.861  75.342  39.701  1.00 61.93           O  
HETATM 1610  O   HOH B  25       0.338  78.896  43.739  1.00 58.48           O  
HETATM 1611  O   HOH B  39       0.311  75.870  46.709  1.00 51.44           O  
HETATM 1612  O   HOH B  42      -6.300  85.234  47.896  1.00 45.21           O  
HETATM 1613  O   HOH B  57      -0.771  69.623  43.730  1.00 63.18           O  
MASTER      457    0    0   11    2    0    0    6 1611    2    0   21          
END

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Related entries of code: 3n00

Entries with 90% protein sequence similarity cutoff in PDBbind
PDB Code	Check Database	Protein Sequence Similarity
No similar entries are found!
Complexes with the same small molecule ligand
PDB Code	Check Database	Ligand Name
1a3b	RCSB PDB PDBbind	21-mer
1rpq	RCSB PDB PDBbind	21-mer
2m55	RCSB PDB PDBbind	21-mer
2oqj	RCSB PDB PDBbind	21-mer
2vay	RCSB PDB PDBbind	21-mer
2zvk	RCSB PDB PDBbind	21-mer
3aa0	RCSB PDB PDBbind	21-mer
3c4m	RCSB PDB PDBbind	21-mer
3ehu	RCSB PDB PDBbind	21-mer

Entry Information

PDB ID	3n00
Complex Type	Protein-Protein
PDBbind Subset	general set
Protein Name	truncated human Rev-erba ligand binding domain
Ligand Name	21-mer
EC.Number	E.C.-.-.-.-
Resolution	2.6(Å)
Affinity (Kd/Ki/IC50)	IC50=0.22uM
Release Year	2010
Protein/NA Sequence	Check fasta file
Primary Reference	(2010) Nat.Struct.Mol.Biol. Vol. 17: pp. 808-814

Links to External Databases

RCSB PDB	The mother database
PDBsum	Enhanced annotations on PDB entries
Pubchem	Comprehensive collection of chemical and biological data
UniProtKB AC	UniProt accession number (AC): O75376 P20393
Entrez Gene ID	NCBI Entrez Gene ID: 9611 9572
ASD	Information of known allosteric effects of PDB entries

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