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Related entries of code: 3pp1
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
3e8nRCSB PDB    PDBbind341aa, >3E8N_1|Chain... at 97%
3eqbRCSB PDB    PDBbind333aa, >3EQB_1|Chain... at 99%
3mblRCSB PDB    PDBbind328aa, >3MBL_1|Chain... at 97%
3v01RCSB PDB    PDBbind341aa, >3V01_1|Chain... at 97%
3v04RCSB PDB    PDBbind341aa, >3V04_1|Chain... at 97%
3zlsRCSB PDB    PDBbind348aa, >3ZLS_1|Chain... at 98%
3zlwRCSB PDB    PDBbind348aa, >3ZLW_1|Chain... at 98%
3zlxRCSB PDB    PDBbind348aa, >3ZLX_1|Chain... at 98%
3zlyRCSB PDB    PDBbind348aa, >3ZLY_1|Chain... at 98%
3zm4RCSB PDB    PDBbind348aa, >3ZM4_1|Chain... at 98%
4arkRCSB PDB    PDBbind341aa, >4ARK_1|Chain... at 97%
4lmnRCSB PDB    PDBbind341aa, >4LMN_1|Chain... at 97%
5eymRCSB PDB    PDBbind359aa, >5EYM_1|Chains... at 98%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
No complexes with the same small molecule ligand are found!
Entry Information
PDB ID3pp1
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameDual specificity mitogen-activated protein kinase kinase 1, MEK1
Ligand NameIZG
EC.Number E.C.2.7.12.2
Resolution 2.7(Å)
Affinity (Kd/Ki/IC50)IC50=3.2nM
Release Year2011
Protein/NA SequenceCheck fasta file
Primary Reference (2011) Bioorg.Med.Chem.Lett. Vol. 21: pp. 1315-1319
Ligand Properties
Formula C17H17F2IN4O4
Molecular Weight 506.243
Exact Mass 506.026
No. of atoms 45
No. of bonds 47
Polar Surface Area 105.47
LOGP Value 0.90      (Computed with XLOGP3)
-0.16      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 3
No. of Hydrogen Bond Acceptors: 4
No. of Rotatable Bonds: 7
No. of Nitrogen and Oxygen Atoms: 8
No. of Rings: 3
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): Q02750  
Entrez Gene IDNCBI Entrez Gene ID: 5604  
ASDInformation of known allosteric effects of PDB entries
 
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