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Related entries of code: 4ff8
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
3qupRCSB PDB    PDBbind323aa, >3QUP_1|Chain... *
4feqRCSB PDB    PDBbind323aa, >4FEQ_1|Chain... at 100%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
No complexes with the same small molecule ligand are found!

Entry Information
PDB ID4ff8
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameTyrosine-protein kinase receptor TYRO3
Ligand Name14S
EC.Number E.C.2.7.10.1
Resolution 2.4(Å)
Affinity (Kd/Ki/IC50)IC50=0.40uM
Release Year2013
Protein/NA SequenceCheck fasta file
Primary Reference (2013) Bioorg.Med.Chem.Lett. Vol. 23: pp. 1046-1050
Ligand Properties
Formula C25H34N6O3
Molecular Weight 466.576
Exact Mass 466.269
No. of atoms 68
No. of bonds 71
Polar Surface Area 108.48
LOGP Value 3.32      (Computed with XLOGP3)
3.67      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 3
No. of Hydrogen Bond Acceptors: 4
No. of Rotatable Bonds: 12
No. of Nitrogen and Oxygen Atoms: 9
No. of Rings: 4
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): P55144  
Entrez Gene IDNCBI Entrez Gene ID: 22174  
ASDInformation of known allosteric effects of PDB entries

 
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