Browse entries in the PDBbind-CN Database
HEADER RNA BINDING PROTEIN/RNA 15-AUG-14 4R3I TITLE THE CRYSTAL STRUCTURE OF AN RNA COMPLEX COMPND MOL_ID: 1; COMPND 2 MOLECULE: YTH DOMAIN-CONTAINING PROTEIN 1; COMPND 3 CHAIN: A; COMPND 4 SYNONYM: PUTATIVE SPLICING FACTOR YT521, YT521-B; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: RNA (5'-R(*GP*GP*(6MZ)P*CP*U)-3'); COMPND 8 CHAIN: B; COMPND 9 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: YTHDC1, KIAA1966, YT521; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 8 EXPRESSION_SYSTEM_STRAIN: BL21-V2R-PRARE2; SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PET28-MHL; SOURCE 11 MOL_ID: 2; SOURCE 12 SYNTHETIC: YES; SOURCE 13 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; SOURCE 14 ORGANISM_TAXID: 32630 KEYWDS STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, RNA BINDING KEYWDS 2 PROTEIN-RNA COMPLEX EXPDTA X-RAY DIFFRACTION AUTHOR W.TEMPEL,C.XU,K.LIU,Y.LI,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN, AUTHOR 2 STRUCTURAL GENOMICS CONSORTIUM (SGC) REVDAT 3 19-NOV-14 4R3I 1 JRNL REVDAT 2 01-OCT-14 4R3I 1 JRNL REVDAT 1 17-SEP-14 4R3I 0 JRNL AUTH C.XU,X.WANG,K.LIU,I.A.ROUNDTREE,W.TEMPEL,Y.LI,Z.LU,C.HE, JRNL AUTH 2 J.MIN JRNL TITL STRUCTURAL BASIS FOR SELECTIVE BINDING OF M(6)A RNA BY THE JRNL TITL 2 YTHDC1 YTH DOMAIN. JRNL REF NAT.CHEM.BIOL. V. 10 927 2014 JRNL REFN ISSN 1552-4450 JRNL PMID 25242552 JRNL DOI 10.1038/NCHEMBIO.1654 REMARK 2 REMARK 2 RESOLUTION. 1.80 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.8.0049 REMARK 3 AUTHORS : MURSHUDOV,VAGIN,DODSON REMARK 3 REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 1.80 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 30.00 REMARK 3 DATA CUTOFF (SIGMA(F)) : 0.000 REMARK 3 COMPLETENESS FOR RANGE (%) : 97.2 REMARK 3 NUMBER OF REFLECTIONS : 14013 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3 R VALUE (WORKING + TEST SET) : 0.206 REMARK 3 R VALUE (WORKING SET) : 0.203 REMARK 3 FREE R VALUE : 0.264 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.000 REMARK 3 FREE R VALUE TEST SET COUNT : 700 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 1.80 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 1.85 REMARK 3 REFLECTION IN BIN (WORKING SET) : 932 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 94.41 REMARK 3 BIN R VALUE (WORKING SET) : 0.2660 REMARK 3 BIN FREE R VALUE SET COUNT : 48 REMARK 3 BIN FREE R VALUE : 0.2910 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 1275 REMARK 3 NUCLEIC ACID ATOMS : 106 REMARK 3 HETEROGEN ATOMS : 7 REMARK 3 SOLVENT ATOMS : 89 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 21.35 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : -1.33000 REMARK 3 B22 (A**2) : -1.57000 REMARK 3 B33 (A**2) : 2.28000 REMARK 3 B12 (A**2) : -0.00000 REMARK 3 B13 (A**2) : 0.74000 REMARK 3 B23 (A**2) : -0.00000 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A): 0.169 REMARK 3 ESU BASED ON FREE R VALUE (A): 0.163 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): 0.128 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 4.237 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.945 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.892 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A): 1430 ; 0.012 ; 0.019 REMARK 3 BOND LENGTHS OTHERS (A): 1308 ; 0.001 ; 0.020 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 1957 ; 1.371 ; 1.923 REMARK 3 BOND ANGLES OTHERS (DEGREES): 3013 ; 0.792 ; 3.000 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 163 ; 6.206 ; 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 55 ;31.952 ;23.636 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 225 ;11.705 ;15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 7 ;15.135 ;15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 215 ; 0.077 ; 0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A): 1525 ; 0.007 ; 0.021 REMARK 3 GENERAL PLANES OTHERS (A): 326 ; 0.001 ; 0.020 REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED CONTACTS OTHERS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) OTHERS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 655 ; 1.826 ; 2.108 REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): 654 ; 1.825 ; 2.102 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 817 ; 2.749 ; 3.144 REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 LONG RANGE B REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 LONG RANGE B OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : MASK REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: DIFFRACTION DATA FOR MOLECULAR REMARK 3 REPLACEMENT AND EARLY REFINEMENT WERE REDUCED WITH HKL3000. COOT REMARK 3 WAS USED FOR INTERACTIVE MODEL BUILDING. MODEL GEOMETRY WAS REMARK 3 EVALUATED WITH MOLPROBITY. REMARK 4 REMARK 4 4R3I COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 25-AUG-14. REMARK 100 THE RCSB ID CODE IS RCSB086852. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 21-JAN-14 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : 6.5 REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : N REMARK 200 RADIATION SOURCE : ROTATING ANODE REMARK 200 BEAMLINE : NULL REMARK 200 X-RAY GENERATOR MODEL : RIGAKU REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 1.5418 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : IMAGE PLATE REMARK 200 DETECTOR MANUFACTURER : RIGAKU RAXIS REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : AIMLESS REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 14029 REMARK 200 RESOLUTION RANGE HIGH (A) : 1.800 REMARK 200 RESOLUTION RANGE LOW (A) : 34.730 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 97.1 REMARK 200 DATA REDUNDANCY : 3.600 REMARK 200 R MERGE (I) : 0.11200 REMARK 200 R SYM (I) : NULL REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : 8.5000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.80 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 1.84 REMARK 200 COMPLETENESS FOR SHELL (%) : 90.7 REMARK 200 DATA REDUNDANCY IN SHELL : 3.30 REMARK 200 R MERGE FOR SHELL (I) : 0.58700 REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 <I/SIGMA(I)> FOR SHELL : 2.300 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: PHASER REMARK 200 STARTING MODEL: A DIFFERENT CRYSTAL FORM OF SAME PROTEIN REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 35.80 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.90 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 25% PEG3350, 0.2 M AMONIUM SULFATE, REMARK 280 0.1 M BIS-TRIS, PH 6.5, VAPOR DIFFUSION, TEMPERATURE 291K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X,Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 19.87400 REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 TOTAL BURIED SURFACE AREA: 1990 ANGSTROM**2 REMARK 350 SURFACE AREA OF THE COMPLEX: 8310 ANGSTROM**2 REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -9.0 KCAL/MOL REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ARG A 508 REMARK 465 HIS A 509 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 THR A 345 OG1 CG2 REMARK 470 SER A 346 OG REMARK 470 LYS A 349 CE NZ REMARK 470 LYS A 374 CD CE NZ REMARK 470 LYS A 386 CD CE NZ REMARK 470 ARG A 392 NE CZ NH1 NH2 REMARK 470 LYS A 408 NZ REMARK 470 LYS A 437 CG CD CE NZ REMARK 470 GLN A 502 CG CD OE1 NE2 REMARK 470 HIS A 505 CG ND1 CD2 CE1 NE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLU A 405 16.26 53.71 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 4R3H RELATED DB: PDB DBREF 4R3I A 345 509 UNP Q96MU7 YTDC1_HUMAN 345 509 DBREF 4R3I B 1 5 PDB 4R3I 4R3I 1 5 SEQADV 4R3I GLY A 344 UNP Q96MU7 EXPRESSION TAG SEQRES 1 A 166 GLY THR SER LYS LEU LYS TYR VAL LEU GLN ASP ALA ARG SEQRES 2 A 166 PHE PHE LEU ILE LYS SER ASN ASN HIS GLU ASN VAL SER SEQRES 3 A 166 LEU ALA LYS ALA LYS GLY VAL TRP SER THR LEU PRO VAL SEQRES 4 A 166 ASN GLU LYS LYS LEU ASN LEU ALA PHE ARG SER ALA ARG SEQRES 5 A 166 SER VAL ILE LEU ILE PHE SER VAL ARG GLU SER GLY LYS SEQRES 6 A 166 PHE GLN GLY PHE ALA ARG LEU SER SER GLU SER HIS HIS SEQRES 7 A 166 GLY GLY SER PRO ILE HIS TRP VAL LEU PRO ALA GLY MET SEQRES 8 A 166 SER ALA LYS MET LEU GLY GLY VAL PHE LYS ILE ASP TRP SEQRES 9 A 166 ILE CYS ARG ARG GLU LEU PRO PHE THR LYS SER ALA HIS SEQRES 10 A 166 LEU THR ASN PRO TRP ASN GLU HIS LYS PRO VAL LYS ILE SEQRES 11 A 166 GLY ARG ASP GLY GLN GLU ILE GLU LEU GLU CYS GLY THR SEQRES 12 A 166 GLN LEU CYS LEU LEU PHE PRO PRO ASP GLU SER ILE ASP SEQRES 13 A 166 LEU TYR GLN VAL ILE HIS LYS MET ARG HIS SEQRES 1 B 5 G G 6MZ C U MODRES 4R3I 6MZ B 3 A N6-METHYLADENOSINE-5'-MONOPHOSPHATE HET 6MZ B 3 23 HET UNX A 601 1 HET UNX A 602 1 HET UNX A 603 1 HET UNX A 604 1 HET UNX A 605 1 HET UNX A 606 1 HET UNX A 607 1 HETNAM 6MZ N6-METHYLADENOSINE-5'-MONOPHOSPHATE HETNAM UNX UNKNOWN ATOM OR ION FORMUL 2 6MZ C11 H16 N5 O7 P FORMUL 3 UNX 7(X) FORMUL 10 HOH *89(H2 O) HELIX 1 1 GLY A 344 GLN A 353 1 10 HELIX 2 2 ASN A 364 GLY A 375 1 12 HELIX 3 3 LEU A 380 ARG A 392 1 13 HELIX 4 4 ALA A 436 GLY A 440 5 5 HELIX 5 5 THR A 456 ALA A 459 5 4 HELIX 6 6 ASN A 463 GLU A 467 5 5 HELIX 7 7 GLU A 481 PHE A 492 1 12 HELIX 8 8 ASP A 499 MET A 507 1 9 SHEET 1 A 6 VAL A 376 TRP A 377 0 SHEET 2 A 6 PHE A 443 CYS A 449 -1 O PHE A 443 N TRP A 377 SHEET 3 A 6 GLY A 411 LEU A 415 -1 N PHE A 412 O ILE A 448 SHEET 4 A 6 SER A 396 VAL A 403 -1 N LEU A 399 O ALA A 413 SHEET 5 A 6 ALA A 355 SER A 362 1 N ARG A 356 O ILE A 398 SHEET 6 A 6 GLU A 479 ILE A 480 -1 O ILE A 480 N PHE A 357 SHEET 1 B 2 LYS A 408 PHE A 409 0 SHEET 2 B 2 LEU A 453 PRO A 454 -1 O LEU A 453 N PHE A 409 LINK O3' G B 2 P 6MZ B 3 1555 1555 1.61 LINK O3' 6MZ B 3 P C B 4 1555 1555 1.59 CRYST1 35.728 39.748 56.238 90.00 103.56 90.00 P 1 21 1 2 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.027989 0.000000 0.006752 0.00000 SCALE2 0.000000 0.025158 0.000000 0.00000 SCALE3 0.000000 0.000000 0.018292 0.00000 ATOM 1 N GLY A 344 38.015 -12.120 62.769 1.00 71.29 N ATOM 2 CA GLY A 344 36.803 -11.939 63.618 1.00 67.00 C ATOM 3 C GLY A 344 36.998 -10.834 64.636 1.00 65.22 C ATOM 4 O GLY A 344 36.750 -9.656 64.344 1.00 54.62 O ATOM 5 N THR A 345 37.443 -11.214 65.833 1.00 66.33 N ATOM 6 CA THR A 345 37.743 -10.243 66.897 1.00 66.32 C ATOM 7 C THR A 345 38.961 -9.360 66.551 1.00 58.34 C ATOM 8 O THR A 345 39.015 -8.208 66.969 1.00 53.06 O ATOM 9 CB THR A 345 37.970 -10.930 68.266 1.00 62.92 C ATOM 10 N SER A 346 39.918 -9.892 65.782 1.00 50.05 N ATOM 11 CA SER A 346 41.106 -9.128 65.399 1.00 46.66 C ATOM 12 C SER A 346 40.715 -7.862 64.644 1.00 42.17 C ATOM 13 O SER A 346 41.283 -6.801 64.892 1.00 37.33 O ATOM 14 CB SER A 346 42.084 -9.963 64.549 1.00 45.14 C ATOM 15 N LYS A 347 39.751 -7.964 63.728 1.00 38.43 N ATOM 16 CA LYS A 347 39.297 -6.777 62.992 1.00 38.90 C ATOM 17 C LYS A 347 38.497 -5.832 63.893 1.00 35.34 C ATOM 18 O LYS A 347 38.703 -4.614 63.854 1.00 30.18 O ATOM 19 CB LYS A 347 38.511 -7.162 61.747 1.00 39.19 C ATOM 20 CG LYS A 347 39.421 -7.696 60.661 1.00 43.11 C ATOM 21 CD LYS A 347 38.657 -8.171 59.451 1.00 48.19 C ATOM 22 CE LYS A 347 39.616 -8.747 58.431 1.00 51.79 C ATOM 23 NZ LYS A 347 38.911 -9.090 57.169 1.00 58.40 N ATOM 24 N LEU A 348 37.603 -6.399 64.706 1.00 33.24 N ATOM 25 CA LEU A 348 36.840 -5.611 65.665 1.00 30.45 C ATOM 26 C LEU A 348 37.804 -4.949 66.630 1.00 28.08 C ATOM 27 O LEU A 348 37.706 -3.762 66.848 1.00 23.13 O ATOM 28 CB LEU A 348 35.814 -6.465 66.419 1.00 30.23 C ATOM 29 CG LEU A 348 34.962 -5.777 67.489 1.00 29.77 C ATOM 30 CD1 LEU A 348 34.242 -4.572 66.917 1.00 31.87 C ATOM 31 CD2 LEU A 348 33.956 -6.753 68.073 1.00 30.20 C ATOM 32 N LYS A 349 38.765 -5.703 67.171 1.00 29.34 N ATOM 33 CA LYS A 349 39.658 -5.162 68.221 1.00 29.72 C ATOM 34 C LYS A 349 40.519 -4.060 67.647 1.00 29.13 C ATOM 35 O LYS A 349 40.922 -3.124 68.359 1.00 28.87 O ATOM 36 CB LYS A 349 40.535 -6.247 68.881 1.00 31.34 C ATOM 37 CG LYS A 349 39.854 -7.045 69.994 1.00 32.21 C ATOM 38 CD LYS A 349 40.848 -7.546 71.029 1.00 32.53 C ATOM 39 N TYR A 350 40.806 -4.174 66.358 1.00 28.11 N ATOM 40 CA TYR A 350 41.512 -3.138 65.644 1.00 29.94 C ATOM 41 C TYR A 350 40.652 -1.885 65.597 1.00 28.86 C ATOM 42 O TYR A 350 41.124 -0.787 65.897 1.00 26.95 O ATOM 43 CB TYR A 350 41.849 -3.592 64.212 1.00 32.82 C ATOM 44 CG TYR A 350 42.663 -2.583 63.467 1.00 35.09 C ATOM 45 CD1 TYR A 350 43.995 -2.372 63.791 1.00 39.25 C ATOM 46 CD2 TYR A 350 42.104 -1.812 62.468 1.00 39.80 C ATOM 47 CE1 TYR A 350 44.760 -1.431 63.122 1.00 41.89 C ATOM 48 CE2 TYR A 350 42.858 -0.868 61.790 1.00 45.32 C ATOM 49 CZ TYR A 350 44.190 -0.685 62.123 1.00 42.48 C ATOM 50 OH TYR A 350 44.949 0.248 61.455 1.00 46.70 O ATOM 51 N VAL A 351 39.385 -2.041 65.216 1.00 23.98 N ATOM 52 CA VAL A 351 38.498 -0.899 65.151 1.00 22.92 C ATOM 53 C VAL A 351 38.294 -0.296 66.550 1.00 20.84 C ATOM 54 O VAL A 351 38.170 0.930 66.679 1.00 23.04 O ATOM 55 CB VAL A 351 37.153 -1.232 64.473 1.00 24.78 C ATOM 56 CG1 VAL A 351 36.219 -0.029 64.539 1.00 24.63 C ATOM 57 CG2 VAL A 351 37.363 -1.648 63.016 1.00 25.01 C ATOM 58 N LEU A 352 38.265 -1.122 67.592 1.00 19.32 N ATOM 59 CA LEU A 352 38.096 -0.603 68.965 1.00 19.95 C ATOM 60 C LEU A 352 39.366 0.044 69.530 1.00 22.32 C ATOM 61 O LEU A 352 39.300 0.787 70.509 1.00 21.68 O ATOM 62 CB LEU A 352 37.627 -1.695 69.936 1.00 23.30 C ATOM 63 CG LEU A 352 36.276 -2.403 69.644 1.00 22.49 C ATOM 64 CD1 LEU A 352 36.030 -3.488 70.690 1.00 21.78 C ATOM 65 CD2 LEU A 352 35.094 -1.445 69.580 1.00 22.22 C ATOM 66 N GLN A 353 40.520 -0.265 68.949 1.00 20.88 N ATOM 67 CA GLN A 353 41.774 0.320 69.408 1.00 23.16 C ATOM 68 C GLN A 353 41.833 1.825 69.126 1.00 21.74 C ATOM 69 O GLN A 353 41.403 2.287 68.078 1.00 21.00 O ATOM 70 CB GLN A 353 42.941 -0.415 68.782 1.00 24.37 C ATOM 71 CG GLN A 353 44.289 0.161 69.100 1.00 25.34 C ATOM 72 CD GLN A 353 45.371 -0.640 68.444 1.00 27.10 C ATOM 73 OE1 GLN A 353 45.558 -0.563 67.219 1.00 27.19 O ATOM 74 NE2 GLN A 353 46.069 -1.450 69.237 1.00 27.11 N ATOM 75 N ASP A 354 42.329 2.568 70.109 1.00 22.80 N ATOM 76 CA ASP A 354 42.482 4.038 70.049 1.00 22.53 C ATOM 77 C ASP A 354 41.133 4.808 70.104 1.00 20.15 C ATOM 78 O ASP A 354 41.085 6.028 69.875 1.00 21.66 O ATOM 79 CB ASP A 354 43.246 4.465 68.772 1.00 22.69 C ATOM 80 CG ASP A 354 44.758 4.346 68.902 1.00 22.76 C ATOM 81 OD1 ASP A 354 45.296 4.029 70.015 1.00 21.53 O ATOM 82 OD2 ASP A 354 45.401 4.612 67.859 1.00 22.81 O ATOM 83 N ALA A 355 40.063 4.108 70.410 1.00 19.35 N ATOM 84 CA ALA A 355 38.738 4.689 70.282 1.00 17.03 C ATOM 85 C ALA A 355 38.320 5.415 71.526 1.00 16.70 C ATOM 86 O ALA A 355 38.697 5.038 72.668 1.00 15.74 O ATOM 87 CB ALA A 355 37.718 3.594 69.989 1.00 19.11 C ATOM 88 N ARG A 356 37.452 6.387 71.319 1.00 15.15 N ATOM 89 CA ARG A 356 36.680 6.937 72.404 1.00 15.20 C ATOM 90 C ARG A 356 35.256 6.429 72.221 1.00 15.00 C ATOM 91 O ARG A 356 34.777 6.257 71.075 1.00 13.86 O ATOM 92 CB ARG A 356 36.721 8.433 72.368 1.00 17.20 C ATOM 93 CG ARG A 356 38.140 8.940 72.488 1.00 18.68 C ATOM 94 CD ARG A 356 38.195 10.433 72.522 1.00 20.05 C ATOM 95 NE ARG A 356 37.483 10.993 73.685 1.00 20.99 N ATOM 96 CZ ARG A 356 37.451 12.284 73.951 1.00 22.04 C ATOM 97 NH1 ARG A 356 38.095 13.131 73.161 1.00 22.70 N ATOM 98 NH2 ARG A 356 36.786 12.733 75.002 1.00 24.04 N ATOM 99 N PHE A 357 34.608 6.169 73.348 1.00 12.94 N ATOM 100 CA PHE A 357 33.289 5.555 73.370 1.00 13.42 C ATOM 101 C PHE A 357 32.272 6.529 73.974 1.00 12.95 C ATOM 102 O PHE A 357 32.461 7.015 75.101 1.00 11.45 O ATOM 103 CB PHE A 357 33.368 4.295 74.223 1.00 14.43 C ATOM 104 CG PHE A 357 34.330 3.262 73.681 1.00 15.02 C ATOM 105 CD1 PHE A 357 33.928 2.359 72.729 1.00 15.26 C ATOM 106 CD2 PHE A 357 35.666 3.233 74.103 1.00 15.89 C ATOM 107 CE1 PHE A 357 34.800 1.416 72.218 1.00 15.50 C ATOM 108 CE2 PHE A 357 36.545 2.298 73.597 1.00 14.89 C ATOM 109 CZ PHE A 357 36.120 1.383 72.646 1.00 15.58 C ATOM 110 N PHE A 358 31.194 6.806 73.247 1.00 13.49 N ATOM 111 CA PHE A 358 30.059 7.570 73.816 1.00 13.59 C ATOM 112 C PHE A 358 28.762 6.769 73.820 1.00 13.31 C ATOM 113 O PHE A 358 28.387 6.179 72.817 1.00 12.05 O ATOM 114 CB PHE A 358 29.854 8.901 73.114 1.00 14.49 C ATOM 115 CG PHE A 358 31.042 9.808 73.219 1.00 14.16 C ATOM 116 CD1 PHE A 358 32.159 9.614 72.389 1.00 15.03 C ATOM 117 CD2 PHE A 358 31.076 10.838 74.145 1.00 14.15 C ATOM 118 CE1 PHE A 358 33.260 10.446 72.468 1.00 15.07 C ATOM 119 CE2 PHE A 358 32.193 11.660 74.228 1.00 15.42 C ATOM 120 CZ PHE A 358 33.275 11.470 73.379 1.00 15.49 C ATOM 121 N LEU A 359 28.137 6.723 74.985 1.00 13.31 N ATOM 122 CA LEU A 359 26.735 6.336 75.096 1.00 14.52 C ATOM 123 C LEU A 359 25.795 7.312 74.345 1.00 15.19 C ATOM 124 O LEU A 359 25.858 8.515 74.547 1.00 16.29 O ATOM 125 CB LEU A 359 26.333 6.308 76.580 1.00 14.21 C ATOM 126 CG LEU A 359 24.967 5.718 76.876 1.00 15.89 C ATOM 127 CD1 LEU A 359 24.948 4.271 76.401 1.00 15.69 C ATOM 128 CD2 LEU A 359 24.666 5.841 78.376 1.00 16.35 C ATOM 129 N ILE A 360 24.908 6.779 73.519 1.00 14.18 N ATOM 130 CA ILE A 360 23.924 7.550 72.826 1.00 12.85 C ATOM 131 C ILE A 360 22.571 7.106 73.294 1.00 12.70 C ATOM 132 O ILE A 360 22.274 5.906 73.272 1.00 11.72 O ATOM 133 CB ILE A 360 24.086 7.364 71.316 1.00 13.27 C ATOM 134 CG1 ILE A 360 25.389 8.034 70.861 1.00 15.26 C ATOM 135 CG2 ILE A 360 22.870 7.893 70.553 1.00 13.86 C ATOM 136 CD1 ILE A 360 25.453 9.550 71.047 1.00 15.43 C ATOM 137 N LYS A 361 21.731 8.044 73.754 1.00 12.14 N ATOM 138 CA LYS A 361 20.361 7.660 74.157 1.00 12.46 C ATOM 139 C LYS A 361 19.375 8.229 73.137 1.00 12.00 C ATOM 140 O LYS A 361 19.543 9.346 72.657 1.00 11.98 O ATOM 141 CB LYS A 361 19.993 8.131 75.571 1.00 13.70 C ATOM 142 CG LYS A 361 20.853 7.592 76.677 1.00 13.71 C ATOM 143 CD LYS A 361 20.776 6.066 76.833 1.00 14.52 C ATOM 144 CE LYS A 361 19.429 5.609 77.394 1.00 15.36 C ATOM 145 NZ LYS A 361 19.383 4.150 77.726 1.00 14.25 N ATOM 146 N SER A 362 18.349 7.446 72.812 1.00 12.80 N ATOM 147 CA SER A 362 17.256 7.913 72.021 1.00 13.38 C ATOM 148 C SER A 362 15.937 7.689 72.777 1.00 13.13 C ATOM 149 O SER A 362 15.727 6.653 73.384 1.00 12.17 O ATOM 150 CB SER A 362 17.228 7.194 70.664 1.00 14.72 C ATOM 151 OG SER A 362 16.029 7.471 69.980 1.00 13.51 O ATOM 152 N ASN A 363 15.060 8.682 72.731 1.00 14.66 N ATOM 153 CA ASN A 363 13.749 8.581 73.368 1.00 16.54 C ATOM 154 C ASN A 363 12.802 7.660 72.589 1.00 16.11 C ATOM 155 O ASN A 363 11.784 7.215 73.107 1.00 17.07 O ATOM 156 CB ASN A 363 13.147 9.975 73.593 1.00 18.26 C ATOM 157 CG ASN A 363 13.595 10.606 74.940 1.00 22.11 C ATOM 158 OD1 ASN A 363 14.528 10.124 75.620 1.00 23.39 O ATOM 159 ND2 ASN A 363 12.927 11.692 75.323 1.00 23.83 N ATOM 160 N ASN A 364 13.156 7.308 71.359 1.00 14.04 N ATOM 161 CA ASN A 364 12.340 6.351 70.634 1.00 14.95 C ATOM 162 C ASN A 364 13.133 5.308 69.825 1.00 15.19 C ATOM 163 O ASN A 364 14.331 5.475 69.604 1.00 14.80 O ATOM 164 CB ASN A 364 11.367 7.107 69.768 1.00 15.50 C ATOM 165 CG ASN A 364 12.058 8.061 68.846 1.00 15.54 C ATOM 166 OD1 ASN A 364 12.810 7.638 67.963 1.00 14.79 O ATOM 167 ND2 ASN A 364 11.805 9.358 69.034 1.00 15.56 N ATOM 168 N HIS A 365 12.461 4.219 69.437 1.00 14.76 N ATOM 169 CA HIS A 365 13.040 3.159 68.607 1.00 14.61 C ATOM 170 C HIS A 365 13.214 3.575 67.170 1.00 14.47 C ATOM 171 O HIS A 365 14.155 3.135 66.499 1.00 15.56 O ATOM 172 CB HIS A 365 12.157 1.921 68.617 1.00 14.48 C ATOM 173 CG HIS A 365 12.111 1.259 69.946 1.00 15.17 C ATOM 174 ND1 HIS A 365 13.095 0.398 70.375 1.00 16.65 N ATOM 175 CD2 HIS A 365 11.240 1.377 70.968 1.00 17.04 C ATOM 176 CE1 HIS A 365 12.812 -0.015 71.604 1.00 15.80 C ATOM 177 NE2 HIS A 365 11.692 0.565 71.985 1.00 18.86 N ATOM 178 N GLU A 366 12.316 4.424 66.701 1.00 13.72 N ATOM 179 CA GLU A 366 12.255 4.753 65.268 1.00 15.69 C ATOM 180 C GLU A 366 13.500 5.524 64.818 1.00 16.06 C ATOM 181 O GLU A 366 13.999 5.320 63.701 1.00 15.82 O ATOM 182 CB GLU A 366 10.975 5.558 64.969 1.00 17.29 C ATOM 183 CG GLU A 366 10.919 6.219 63.593 1.00 17.93 C ATOM 184 CD GLU A 366 10.917 5.259 62.438 1.00 20.56 C ATOM 185 OE1 GLU A 366 10.579 4.069 62.623 1.00 25.62 O ATOM 186 OE2 GLU A 366 11.227 5.724 61.319 1.00 25.64 O ATOM 187 N ASN A 367 14.033 6.385 65.674 1.00 15.07 N ATOM 188 CA ASN A 367 15.220 7.172 65.241 1.00 15.28 C ATOM 189 C ASN A 367 16.466 6.284 65.124 1.00 15.03 C ATOM 190 O ASN A 367 17.327 6.486 64.236 1.00 13.39 O ATOM 191 CB ASN A 367 15.435 8.389 66.158 1.00 16.64 C ATOM 192 CG ASN A 367 14.342 9.469 65.990 1.00 15.74 C ATOM 193 OD1 ASN A 367 13.511 9.414 65.069 1.00 14.04 O ATOM 194 ND2 ASN A 367 14.355 10.461 66.873 1.00 15.01 N ATOM 195 N VAL A 368 16.558 5.290 65.997 1.00 13.75 N ATOM 196 CA VAL A 368 17.641 4.311 65.934 1.00 13.83 C ATOM 197 C VAL A 368 17.518 3.427 64.715 1.00 13.32 C ATOM 198 O VAL A 368 18.523 3.109 64.089 1.00 13.01 O ATOM 199 CB VAL A 368 17.736 3.458 67.223 1.00 14.21 C ATOM 200 CG1 VAL A 368 18.796 2.369 67.087 1.00 13.71 C ATOM 201 CG2 VAL A 368 18.073 4.353 68.406 1.00 13.68 C ATOM 202 N SER A 369 16.291 3.070 64.363 1.00 14.52 N ATOM 203 CA SER A 369 16.033 2.278 63.162 1.00 18.02 C ATOM 204 C SER A 369 16.322 3.064 61.854 1.00 17.55 C ATOM 205 O SER A 369 16.853 2.518 60.890 1.00 17.41 O ATOM 206 CB SER A 369 14.590 1.738 63.190 1.00 19.37 C ATOM 207 OG SER A 369 14.201 1.245 61.909 1.00 25.43 O ATOM 208 N LEU A 370 15.968 4.344 61.835 1.00 18.72 N ATOM 209 CA LEU A 370 16.312 5.220 60.721 1.00 19.87 C ATOM 210 C LEU A 370 17.825 5.364 60.622 1.00 18.81 C ATOM 211 O LEU A 370 18.410 5.323 59.516 1.00 19.36 O ATOM 212 CB LEU A 370 15.671 6.602 60.905 1.00 20.64 C ATOM 213 CG LEU A 370 15.915 7.605 59.768 1.00 23.50 C ATOM 214 CD1 LEU A 370 15.597 7.019 58.389 1.00 24.74 C ATOM 215 CD2 LEU A 370 15.083 8.855 59.992 1.00 24.68 C ATOM 216 N ALA A 371 18.461 5.542 61.777 1.00 16.99 N ATOM 217 CA ALA A 371 19.924 5.611 61.868 1.00 16.94 C ATOM 218 C ALA A 371 20.625 4.334 61.352 1.00 17.60 C ATOM 219 O ALA A 371 21.656 4.401 60.626 1.00 17.83 O ATOM 220 CB ALA A 371 20.346 5.889 63.310 1.00 17.80 C ATOM 221 N LYS A 372 20.084 3.180 61.722 1.00 17.23 N ATOM 222 CA LYS A 372 20.595 1.890 61.223 1.00 18.04 C ATOM 223 C LYS A 372 20.429 1.740 59.711 1.00 18.99 C ATOM 224 O LYS A 372 21.312 1.187 59.027 1.00 19.21 O ATOM 225 CB LYS A 372 19.910 0.730 61.922 1.00 17.60 C ATOM 226 CG LYS A 372 20.519 0.469 63.283 1.00 18.08 C ATOM 227 CD LYS A 372 19.756 -0.583 64.031 1.00 17.70 C ATOM 228 CE LYS A 372 20.552 -1.132 65.186 1.00 18.70 C ATOM 229 NZ LYS A 372 19.801 -2.261 65.824 1.00 18.18 N ATOM 230 N ALA A 373 19.302 2.225 59.208 1.00 20.74 N ATOM 231 CA ALA A 373 18.962 2.097 57.793 1.00 23.24 C ATOM 232 C ALA A 373 19.752 3.055 56.891 1.00 23.05 C ATOM 233 O ALA A 373 20.118 2.676 55.783 1.00 25.17 O ATOM 234 CB ALA A 373 17.459 2.278 57.591 1.00 22.15 C ATOM 235 N LYS A 374 20.033 4.271 57.374 1.00 21.43 N ATOM 236 CA LYS A 374 20.601 5.352 56.549 1.00 22.52 C ATOM 237 C LYS A 374 22.036 5.772 56.918 1.00 20.74 C ATOM 238 O LYS A 374 22.706 6.433 56.124 1.00 21.81 O ATOM 239 CB LYS A 374 19.672 6.578 56.600 1.00 23.30 C ATOM 240 CG LYS A 374 18.284 6.293 56.059 1.00 26.29 C ATOM 241 N GLY A 375 22.498 5.408 58.116 1.00 21.15 N ATOM 242 CA GLY A 375 23.871 5.676 58.525 1.00 20.37 C ATOM 243 C GLY A 375 24.131 7.134 58.860 1.00 19.09 C ATOM 244 O GLY A 375 25.181 7.681 58.525 1.00 16.85 O ATOM 245 N VAL A 376 23.187 7.733 59.571 1.00 17.00 N ATOM 246 CA VAL A 376 23.287 9.100 60.080 1.00 16.71 C ATOM 247 C VAL A 376 22.795 9.138 61.539 1.00 16.11 C ATOM 248 O VAL A 376 22.026 8.270 61.962 1.00 17.32 O ATOM 249 CB VAL A 376 22.446 10.076 59.255 1.00 16.03 C ATOM 250 CG1 VAL A 376 22.948 10.104 57.827 1.00 17.03 C ATOM 251 CG2 VAL A 376 20.977 9.700 59.296 1.00 16.23 C ATOM 252 N TRP A 377 23.272 10.107 62.302 1.00 15.55 N ATOM 253 CA TRP A 377 22.728 10.380 63.631 1.00 15.65 C ATOM 254 C TRP A 377 22.748 11.877 63.896 1.00 17.52 C ATOM 255 O TRP A 377 23.598 12.615 63.350 1.00 15.56 O ATOM 256 CB TRP A 377 23.520 9.668 64.714 1.00 15.36 C ATOM 257 CG TRP A 377 22.892 9.783 66.069 1.00 14.74 C ATOM 258 CD1 TRP A 377 23.426 10.392 67.200 1.00 14.83 C ATOM 259 CD2 TRP A 377 21.617 9.275 66.458 1.00 14.05 C ATOM 260 NE1 TRP A 377 22.533 10.301 68.255 1.00 13.92 N ATOM 261 CE2 TRP A 377 21.428 9.598 67.829 1.00 13.97 C ATOM 262 CE3 TRP A 377 20.596 8.587 65.780 1.00 13.31 C ATOM 263 CZ2 TRP A 377 20.266 9.249 68.505 1.00 13.13 C ATOM 264 CZ3 TRP A 377 19.484 8.244 66.443 1.00 12.10 C ATOM 265 CH2 TRP A 377 19.309 8.579 67.807 1.00 11.81 C ATOM 266 N SER A 378 21.788 12.340 64.702 1.00 18.39 N ATOM 267 CA SER A 378 21.835 13.688 65.246 1.00 18.75 C ATOM 268 C SER A 378 21.704 13.625 66.762 1.00 17.42 C ATOM 269 O SER A 378 20.968 12.793 67.286 1.00 18.60 O ATOM 270 CB SER A 378 20.737 14.546 64.651 1.00 18.80 C ATOM 271 OG SER A 378 20.899 14.682 63.244 1.00 17.23 O ATOM 272 N THR A 379 22.469 14.458 67.463 1.00 17.84 N ATOM 273 CA THR A 379 22.317 14.594 68.927 1.00 16.83 C ATOM 274 C THR A 379 22.047 16.051 69.290 1.00 16.98 C ATOM 275 O THR A 379 22.024 16.920 68.421 1.00 15.09 O ATOM 276 CB THR A 379 23.532 14.045 69.711 1.00 16.28 C ATOM 277 OG1 THR A 379 23.193 13.971 71.111 1.00 15.54 O ATOM 278 CG2 THR A 379 24.829 14.930 69.503 1.00 16.21 C ATOM 279 N LEU A 380 21.810 16.316 70.579 1.00 17.40 N ATOM 280 CA LEU A 380 21.557 17.688 71.034 1.00 17.91 C ATOM 281 C LEU A 380 22.878 18.481 71.040 1.00 16.57 C ATOM 282 O LEU A 380 23.962 17.880 70.988 1.00 13.96 O ATOM 283 CB LEU A 380 20.866 17.671 72.390 1.00 18.00 C ATOM 284 CG LEU A 380 19.489 16.988 72.271 1.00 19.95 C ATOM 285 CD1 LEU A 380 19.018 16.418 73.593 1.00 21.31 C ATOM 286 CD2 LEU A 380 18.472 17.963 71.685 1.00 22.96 C ATOM 287 N PRO A 381 22.791 19.832 71.042 1.00 18.45 N ATOM 288 CA PRO A 381 23.992 20.675 70.824 1.00 18.87 C ATOM 289 C PRO A 381 25.182 20.442 71.731 1.00 17.86 C ATOM 290 O PRO A 381 26.320 20.405 71.259 1.00 18.60 O ATOM 291 CB PRO A 381 23.444 22.090 70.986 1.00 18.85 C ATOM 292 CG PRO A 381 22.056 21.985 70.481 1.00 19.44 C ATOM 293 CD PRO A 381 21.565 20.653 71.009 1.00 19.27 C ATOM 294 N VAL A 382 24.949 20.273 73.021 1.00 16.41 N ATOM 295 CA VAL A 382 26.051 20.015 73.929 1.00 16.48 C ATOM 296 C VAL A 382 26.888 18.775 73.529 1.00 16.01 C ATOM 297 O VAL A 382 28.100 18.851 73.437 1.00 15.10 O ATOM 298 CB VAL A 382 25.563 19.885 75.374 1.00 15.46 C ATOM 299 CG1 VAL A 382 26.684 19.356 76.262 1.00 17.24 C ATOM 300 CG2 VAL A 382 25.050 21.206 75.874 1.00 17.14 C ATOM 301 N ASN A 383 26.226 17.634 73.297 1.00 15.19 N ATOM 302 CA ASN A 383 26.917 16.417 72.853 1.00 16.94 C ATOM 303 C ASN A 383 27.487 16.531 71.460 1.00 15.99 C ATOM 304 O ASN A 383 28.501 15.864 71.122 1.00 15.74 O ATOM 305 CB ASN A 383 25.948 15.225 72.880 1.00 16.23 C ATOM 306 CG ASN A 383 25.457 14.908 74.279 1.00 19.22 C ATOM 307 OD1 ASN A 383 26.015 15.363 75.279 1.00 21.73 O ATOM 308 ND2 ASN A 383 24.418 14.100 74.355 1.00 21.28 N ATOM 309 N GLU A 384 26.811 17.310 70.622 1.00 16.92 N ATOM 310 CA GLU A 384 27.256 17.486 69.238 1.00 18.20 C ATOM 311 C GLU A 384 28.645 18.103 69.264 1.00 17.77 C ATOM 312 O GLU A 384 29.550 17.650 68.540 1.00 17.39 O ATOM 313 CB GLU A 384 26.305 18.375 68.464 1.00 19.00 C ATOM 314 CG GLU A 384 26.683 18.572 67.005 1.00 20.73 C ATOM 315 CD GLU A 384 25.829 19.637 66.333 1.00 23.60 C ATOM 316 OE1 GLU A 384 25.008 20.280 67.019 1.00 23.06 O ATOM 317 OE2 GLU A 384 25.986 19.853 65.110 1.00 27.38 O ATOM 318 N LYS A 385 28.837 19.094 70.149 1.00 18.74 N ATOM 319 CA LYS A 385 30.135 19.754 70.314 1.00 19.92 C ATOM 320 C LYS A 385 31.167 18.762 70.832 1.00 18.23 C ATOM 321 O LYS A 385 32.289 18.694 70.321 1.00 20.66 O ATOM 322 CB LYS A 385 30.011 20.967 71.264 1.00 23.96 C ATOM 323 CG LYS A 385 31.309 21.707 71.591 1.00 27.95 C ATOM 324 CD LYS A 385 32.026 22.192 70.338 1.00 30.98 C ATOM 325 CE LYS A 385 33.098 23.241 70.638 1.00 33.12 C ATOM 326 NZ LYS A 385 33.865 23.589 69.401 1.00 33.35 N ATOM 327 N LYS A 386 30.789 17.983 71.845 1.00 17.53 N ATOM 328 CA LYS A 386 31.705 16.988 72.425 1.00 18.43 C ATOM 329 C LYS A 386 32.117 15.948 71.382 1.00 17.33 C ATOM 330 O LYS A 386 33.277 15.555 71.311 1.00 17.53 O ATOM 331 CB LYS A 386 31.077 16.292 73.638 1.00 19.65 C ATOM 332 CG LYS A 386 30.841 17.224 74.823 1.00 21.00 C ATOM 333 N LEU A 387 31.172 15.508 70.571 1.00 17.20 N ATOM 334 CA LEU A 387 31.484 14.515 69.534 1.00 18.36 C ATOM 335 C LEU A 387 32.410 15.055 68.424 1.00 19.45 C ATOM 336 O LEU A 387 33.362 14.379 68.024 1.00 18.48 O ATOM 337 CB LEU A 387 30.200 13.923 68.931 1.00 18.29 C ATOM 338 CG LEU A 387 29.382 12.949 69.795 1.00 16.28 C ATOM 339 CD1 LEU A 387 28.146 12.495 69.022 1.00 16.15 C ATOM 340 CD2 LEU A 387 30.208 11.752 70.255 1.00 18.40 C ATOM 341 N ASN A 388 32.139 16.252 67.927 1.00 20.14 N ATOM 342 CA ASN A 388 33.057 16.890 66.937 1.00 19.96 C ATOM 343 C ASN A 388 34.490 16.988 67.444 1.00 19.81 C ATOM 344 O ASN A 388 35.449 16.587 66.763 1.00 19.81 O ATOM 345 CB ASN A 388 32.487 18.246 66.523 1.00 20.49 C ATOM 346 CG ASN A 388 31.322 18.105 65.583 1.00 19.89 C ATOM 347 OD1 ASN A 388 31.317 17.196 64.760 1.00 21.59 O ATOM 348 ND2 ASN A 388 30.328 18.977 65.695 1.00 21.99 N ATOM 349 N LEU A 389 34.644 17.429 68.693 1.00 21.56 N ATOM 350 CA LEU A 389 35.942 17.514 69.301 1.00 20.66 C ATOM 351 C LEU A 389 36.619 16.163 69.379 1.00 19.42 C ATOM 352 O LEU A 389 37.807 16.050 69.106 1.00 16.48 O ATOM 353 CB LEU A 389 35.847 18.113 70.712 1.00 21.66 C ATOM 354 CG LEU A 389 35.585 19.610 70.776 1.00 23.41 C ATOM 355 CD1 LEU A 389 35.218 19.998 72.202 1.00 25.47 C ATOM 356 CD2 LEU A 389 36.809 20.384 70.334 1.00 22.49 C ATOM 357 N ALA A 390 35.856 15.143 69.769 1.00 19.48 N ATOM 358 CA ALA A 390 36.390 13.791 69.957 1.00 19.24 C ATOM 359 C ALA A 390 36.845 13.185 68.648 1.00 18.62 C ATOM 360 O ALA A 390 37.844 12.459 68.588 1.00 18.27 O ATOM 361 CB ALA A 390 35.350 12.895 70.607 1.00 20.27 C ATOM 362 N PHE A 391 36.116 13.493 67.599 1.00 18.64 N ATOM 363 CA PHE A 391 36.413 12.981 66.259 1.00 20.56 C ATOM 364 C PHE A 391 37.838 13.271 65.834 1.00 24.43 C ATOM 365 O PHE A 391 38.473 12.438 65.190 1.00 25.83 O ATOM 366 CB PHE A 391 35.460 13.610 65.273 1.00 20.21 C ATOM 367 CG PHE A 391 35.568 13.070 63.873 1.00 20.23 C ATOM 368 CD1 PHE A 391 35.147 11.769 63.569 1.00 18.73 C ATOM 369 CD2 PHE A 391 36.029 13.877 62.833 1.00 20.66 C ATOM 370 CE1 PHE A 391 35.217 11.280 62.265 1.00 19.77 C ATOM 371 CE2 PHE A 391 36.102 13.378 61.525 1.00 20.14 C ATOM 372 CZ PHE A 391 35.697 12.082 61.248 1.00 19.67 C ATOM 373 N ARG A 392 38.319 14.461 66.211 1.00 29.23 N ATOM 374 CA ARG A 392 39.622 14.985 65.814 1.00 28.66 C ATOM 375 C ARG A 392 40.729 14.572 66.767 1.00 31.71 C ATOM 376 O ARG A 392 41.871 14.932 66.536 1.00 32.24 O ATOM 377 CB ARG A 392 39.575 16.514 65.778 1.00 28.65 C ATOM 378 CG ARG A 392 38.339 17.086 65.086 1.00 29.26 C ATOM 379 CD ARG A 392 38.449 18.587 64.852 1.00 33.20 C ATOM 380 N SER A 393 40.404 13.842 67.837 1.00 30.16 N ATOM 381 CA SER A 393 41.393 13.485 68.843 1.00 32.20 C ATOM 382 C SER A 393 41.705 11.998 68.903 1.00 29.95 C ATOM 383 O SER A 393 42.605 11.595 69.647 1.00 30.62 O ATOM 384 CB SER A 393 40.906 13.931 70.237 1.00 32.37 C ATOM 385 OG SER A 393 39.963 13.006 70.774 1.00 30.86 O ATOM 386 N ALA A 394 40.946 11.189 68.167 1.00 26.90 N ATOM 387 CA ALA A 394 41.060 9.738 68.231 1.00 25.22 C ATOM 388 C ALA A 394 40.927 9.140 66.866 1.00 23.81 C ATOM 389 O ALA A 394 40.271 9.727 66.009 1.00 22.01 O ATOM 390 CB ALA A 394 39.960 9.192 69.113 1.00 27.09 C ATOM 391 N ARG A 395 41.532 7.965 66.660 1.00 24.66 N ATOM 392 CA ARG A 395 41.426 7.263 65.382 1.00 26.20 C ATOM 393 C ARG A 395 39.937 7.016 65.103 1.00 24.70 C ATOM 394 O ARG A 395 39.487 7.103 63.954 1.00 23.52 O ATOM 395 CB ARG A 395 42.248 5.923 65.365 1.00 28.50 C ATOM 396 CG ARG A 395 42.089 5.123 64.066 1.00 31.02 C ATOM 397 CD ARG A 395 43.119 4.006 63.857 1.00 35.56 C ATOM 398 NE ARG A 395 42.833 2.756 64.597 1.00 36.15 N ATOM 399 CZ ARG A 395 43.764 1.894 65.039 1.00 43.38 C ATOM 400 NH1 ARG A 395 43.397 0.804 65.712 1.00 44.73 N ATOM 401 NH2 ARG A 395 45.069 2.121 64.845 1.00 38.68 N ATOM 402 N SER A 396 39.180 6.739 66.169 1.00 21.75 N ATOM 403 CA SER A 396 37.744 6.401 66.065 1.00 20.16 C ATOM 404 C SER A 396 36.937 6.894 67.268 1.00 17.95 C ATOM 405 O SER A 396 37.367 6.800 68.423 1.00 13.99 O ATOM 406 CB SER A 396 37.569 4.880 65.989 1.00 22.45 C ATOM 407 OG SER A 396 38.307 4.273 64.942 1.00 21.95 O ATOM 408 N VAL A 397 35.729 7.374 66.996 1.00 18.03 N ATOM 409 CA VAL A 397 34.770 7.620 68.036 1.00 17.51 C ATOM 410 C VAL A 397 33.648 6.620 67.812 1.00 16.05 C ATOM 411 O VAL A 397 33.062 6.580 66.715 1.00 15.24 O ATOM 412 CB VAL A 397 34.208 9.045 67.927 1.00 17.90 C ATOM 413 CG1 VAL A 397 33.035 9.239 68.879 1.00 17.87 C ATOM 414 CG2 VAL A 397 35.332 10.071 68.144 1.00 16.59 C ATOM 415 N ILE A 398 33.381 5.829 68.835 1.00 14.92 N ATOM 416 CA ILE A 398 32.359 4.792 68.808 1.00 15.53 C ATOM 417 C ILE A 398 31.129 5.266 69.584 1.00 13.53 C ATOM 418 O ILE A 398 31.211 5.646 70.770 1.00 13.31 O ATOM 419 CB ILE A 398 32.900 3.474 69.384 1.00 15.50 C ATOM 420 CG1 ILE A 398 34.140 3.030 68.617 1.00 16.73 C ATOM 421 CG2 ILE A 398 31.813 2.396 69.398 1.00 15.97 C ATOM 422 CD1 ILE A 398 33.874 2.466 67.249 1.00 16.13 C ATOM 423 N LEU A 399 29.994 5.232 68.915 1.00 13.49 N ATOM 424 CA LEU A 399 28.690 5.561 69.514 1.00 13.13 C ATOM 425 C LEU A 399 27.969 4.250 69.881 1.00 12.53 C ATOM 426 O LEU A 399 27.788 3.373 69.013 1.00 15.00 O ATOM 427 CB LEU A 399 27.862 6.316 68.520 1.00 12.89 C ATOM 428 CG LEU A 399 28.351 7.643 67.976 1.00 14.01 C ATOM 429 CD1 LEU A 399 27.203 8.277 67.232 1.00 13.31 C ATOM 430 CD2 LEU A 399 28.844 8.504 69.114 1.00 15.16 C ATOM 431 N ILE A 400 27.626 4.083 71.140 1.00 12.04 N ATOM 432 CA ILE A 400 26.976 2.853 71.588 1.00 12.40 C ATOM 433 C ILE A 400 25.525 3.250 71.902 1.00 12.43 C ATOM 434 O ILE A 400 25.286 4.066 72.818 1.00 11.02 O ATOM 435 CB ILE A 400 27.650 2.236 72.834 1.00 13.08 C ATOM 436 CG1 ILE A 400 29.144 1.996 72.594 1.00 13.42 C ATOM 437 CG2 ILE A 400 26.959 0.933 73.177 1.00 12.77 C ATOM 438 CD1 ILE A 400 29.903 1.452 73.801 1.00 13.77 C ATOM 439 N PHE A 401 24.568 2.680 71.159 1.00 11.95 N ATOM 440 CA PHE A 401 23.173 3.162 71.174 1.00 12.45 C ATOM 441 C PHE A 401 22.336 2.431 72.215 1.00 11.28 C ATOM 442 O PHE A 401 22.421 1.226 72.357 1.00 11.70 O ATOM 443 CB PHE A 401 22.516 3.007 69.769 1.00 13.06 C ATOM 444 CG PHE A 401 23.022 3.987 68.733 1.00 13.38 C ATOM 445 CD1 PHE A 401 24.292 3.828 68.140 1.00 14.33 C ATOM 446 CD2 PHE A 401 22.251 5.091 68.368 1.00 14.63 C ATOM 447 CE1 PHE A 401 24.755 4.737 67.195 1.00 14.34 C ATOM 448 CE2 PHE A 401 22.720 5.997 67.416 1.00 15.13 C ATOM 449 CZ PHE A 401 23.975 5.816 66.837 1.00 14.06 C ATOM 450 N SER A 402 21.518 3.169 72.937 1.00 11.00 N ATOM 451 CA SER A 402 20.511 2.582 73.849 1.00 10.47 C ATOM 452 C SER A 402 19.233 3.409 73.846 1.00 11.03 C ATOM 453 O SER A 402 19.212 4.605 74.279 1.00 11.91 O ATOM 454 CB SER A 402 21.073 2.540 75.244 1.00 11.08 C ATOM 455 OG SER A 402 20.107 2.063 76.131 1.00 10.94 O ATOM 456 N VAL A 403 18.132 2.771 73.432 1.00 11.77 N ATOM 457 CA VAL A 403 16.830 3.433 73.492 1.00 11.31 C ATOM 458 C VAL A 403 16.420 3.572 74.965 1.00 12.41 C ATOM 459 O VAL A 403 16.491 2.615 75.714 1.00 12.59 O ATOM 460 CB VAL A 403 15.781 2.689 72.687 1.00 11.26 C ATOM 461 CG1 VAL A 403 14.397 3.381 72.840 1.00 10.55 C ATOM 462 CG2 VAL A 403 16.234 2.580 71.213 1.00 10.91 C ATOM 463 N ARG A 404 15.986 4.764 75.367 1.00 13.66 N ATOM 464 CA ARG A 404 15.615 4.977 76.776 1.00 15.17 C ATOM 465 C ARG A 404 14.451 4.025 77.207 1.00 15.30 C ATOM 466 O ARG A 404 13.546 3.702 76.450 1.00 17.43 O ATOM 467 CB ARG A 404 15.309 6.455 77.043 1.00 16.74 C ATOM 468 CG ARG A 404 15.131 6.808 78.512 1.00 19.30 C ATOM 469 CD ARG A 404 14.917 8.298 78.714 1.00 22.94 C ATOM 470 NE ARG A 404 13.665 8.777 78.127 1.00 25.67 N ATOM 471 CZ ARG A 404 12.442 8.611 78.634 1.00 27.89 C ATOM 472 NH1 ARG A 404 11.418 9.131 77.977 1.00 28.27 N ATOM 473 NH2 ARG A 404 12.224 7.968 79.801 1.00 29.58 N ATOM 474 N GLU A 405 14.548 3.557 78.437 1.00 15.26 N ATOM 475 CA GLU A 405 13.694 2.511 78.996 1.00 16.79 C ATOM 476 C GLU A 405 13.582 1.186 78.233 1.00 16.60 C ATOM 477 O GLU A 405 12.697 0.378 78.526 1.00 17.24 O ATOM 478 CB GLU A 405 12.302 3.088 79.305 1.00 18.14 C ATOM 479 CG GLU A 405 12.350 4.175 80.376 1.00 20.33 C ATOM 480 CD GLU A 405 10.958 4.557 80.873 1.00 23.76 C ATOM 481 OE1 GLU A 405 10.016 4.553 80.058 1.00 28.74 O ATOM 482 OE2 GLU A 405 10.803 4.810 82.089 1.00 30.57 O ATOM 483 N SER A 406 14.484 0.913 77.306 1.00 15.68 N ATOM 484 CA SER A 406 14.436 -0.344 76.552 1.00 14.83 C ATOM 485 C SER A 406 15.095 -1.537 77.250 1.00 15.66 C ATOM 486 O SER A 406 14.916 -2.712 76.843 1.00 13.86 O ATOM 487 CB SER A 406 15.075 -0.171 75.159 1.00 12.69 C ATOM 488 OG SER A 406 16.501 -0.052 75.218 1.00 11.86 O ATOM 489 N GLY A 407 15.906 -1.271 78.263 1.00 16.28 N ATOM 490 CA GLY A 407 16.629 -2.351 78.942 1.00 16.27 C ATOM 491 C GLY A 407 17.742 -2.991 78.093 1.00 16.34 C ATOM 492 O GLY A 407 18.295 -4.019 78.489 1.00 15.22 O ATOM 493 N LYS A 408 18.078 -2.371 76.944 1.00 16.55 N ATOM 494 CA LYS A 408 19.080 -2.891 76.007 1.00 18.69 C ATOM 495 C LYS A 408 19.921 -1.796 75.349 1.00 17.11 C ATOM 496 O LYS A 408 19.478 -0.666 75.226 1.00 14.69 O ATOM 497 CB LYS A 408 18.392 -3.588 74.824 1.00 19.78 C ATOM 498 CG LYS A 408 17.359 -4.626 75.177 1.00 21.89 C ATOM 499 CD LYS A 408 16.590 -4.986 73.925 1.00 21.24 C ATOM 500 CE LYS A 408 15.586 -6.102 74.168 1.00 26.07 C ATOM 501 N PHE A 409 21.094 -2.196 74.839 1.00 14.95 N ATOM 502 CA PHE A 409 21.763 -1.485 73.768 1.00 13.66 C ATOM 503 C PHE A 409 21.333 -2.098 72.428 1.00 13.67 C ATOM 504 O PHE A 409 21.218 -3.323 72.317 1.00 16.79 O ATOM 505 CB PHE A 409 23.298 -1.615 73.864 1.00 12.70 C ATOM 506 CG PHE A 409 23.866 -1.305 75.210 1.00 12.63 C ATOM 507 CD1 PHE A 409 24.012 -2.298 76.174 1.00 12.50 C ATOM 508 CD2 PHE A 409 24.309 -0.008 75.499 1.00 13.19 C ATOM 509 CE1 PHE A 409 24.560 -1.991 77.418 1.00 13.15 C ATOM 510 CE2 PHE A 409 24.834 0.314 76.763 1.00 13.14 C ATOM 511 CZ PHE A 409 24.980 -0.663 77.696 1.00 13.15 C ATOM 512 N GLN A 410 21.233 -1.258 71.393 1.00 14.11 N ATOM 513 CA GLN A 410 20.754 -1.648 70.056 1.00 14.22 C ATOM 514 C GLN A 410 21.829 -1.770 69.014 1.00 14.42 C ATOM 515 O GLN A 410 21.541 -2.151 67.871 1.00 14.61 O ATOM 516 CB GLN A 410 19.683 -0.655 69.544 1.00 14.56 C ATOM 517 CG GLN A 410 18.303 -0.862 70.146 1.00 15.76 C ATOM 518 CD GLN A 410 18.178 -0.333 71.564 1.00 16.37 C ATOM 519 OE1 GLN A 410 18.846 0.623 71.928 1.00 15.26 O ATOM 520 NE2 GLN A 410 17.289 -0.924 72.351 1.00 15.54 N ATOM 521 N GLY A 411 23.075 -1.438 69.395 1.00 15.63 N ATOM 522 CA GLY A 411 24.240 -1.689 68.578 1.00 15.72 C ATOM 523 C GLY A 411 25.258 -0.609 68.774 1.00 15.10 C ATOM 524 O GLY A 411 25.090 0.239 69.651 1.00 14.05 O ATOM 525 N PHE A 412 26.295 -0.624 67.941 1.00 15.10 N ATOM 526 CA PHE A 412 27.293 0.469 67.911 1.00 14.90 C ATOM 527 C PHE A 412 27.869 0.818 66.536 1.00 14.87 C ATOM 528 O PHE A 412 27.963 -0.029 65.634 1.00 13.36 O ATOM 529 CB PHE A 412 28.422 0.256 68.921 1.00 16.15 C ATOM 530 CG PHE A 412 29.258 -1.014 68.710 1.00 16.04 C ATOM 531 CD1 PHE A 412 28.870 -2.212 69.283 1.00 16.53 C ATOM 532 CD2 PHE A 412 30.497 -0.959 68.054 1.00 15.59 C ATOM 533 CE1 PHE A 412 29.648 -3.350 69.156 1.00 15.53 C ATOM 534 CE2 PHE A 412 31.275 -2.090 67.913 1.00 15.18 C ATOM 535 CZ PHE A 412 30.846 -3.287 68.469 1.00 15.05 C ATOM 536 N ALA A 413 28.313 2.066 66.421 1.00 14.25 N ATOM 537 CA ALA A 413 28.776 2.618 65.162 1.00 15.86 C ATOM 538 C ALA A 413 29.993 3.502 65.376 1.00 17.66 C ATOM 539 O ALA A 413 30.275 3.955 66.483 1.00 16.17 O ATOM 540 CB ALA A 413 27.681 3.434 64.508 1.00 16.09 C ATOM 541 N ARG A 414 30.689 3.762 64.288 1.00 16.45 N ATOM 542 CA ARG A 414 31.827 4.666 64.309 1.00 18.81 C ATOM 543 C ARG A 414 31.482 5.919 63.557 1.00 17.65 C ATOM 544 O ARG A 414 30.990 5.830 62.445 1.00 19.99 O ATOM 545 CB ARG A 414 33.006 3.975 63.650 1.00 17.90 C ATOM 546 CG ARG A 414 34.265 4.787 63.584 1.00 18.58 C ATOM 547 CD ARG A 414 35.312 4.085 62.748 1.00 20.24 C ATOM 548 NE ARG A 414 36.499 4.930 62.691 1.00 20.50 N ATOM 549 CZ ARG A 414 36.695 5.932 61.849 1.00 20.73 C ATOM 550 NH1 ARG A 414 35.813 6.229 60.899 1.00 23.31 N ATOM 551 NH2 ARG A 414 37.808 6.627 61.943 1.00 21.41 N ATOM 552 N LEU A 415 31.736 7.086 64.147 1.00 18.37 N ATOM 553 CA LEU A 415 31.617 8.373 63.423 1.00 19.70 C ATOM 554 C LEU A 415 32.506 8.390 62.179 1.00 21.24 C ATOM 555 O LEU A 415 33.715 8.153 62.297 1.00 22.47 O ATOM 556 CB LEU A 415 32.069 9.551 64.299 1.00 20.31 C ATOM 557 CG LEU A 415 31.102 10.152 65.307 1.00 21.22 C ATOM 558 CD1 LEU A 415 31.700 11.405 65.948 1.00 19.81 C ATOM 559 CD2 LEU A 415 29.768 10.428 64.632 1.00 22.38 C ATOM 560 N SER A 416 31.922 8.676 61.008 1.00 19.91 N ATOM 561 CA SER A 416 32.717 8.841 59.778 1.00 21.49 C ATOM 562 C SER A 416 32.918 10.304 59.405 1.00 21.47 C ATOM 563 O SER A 416 33.744 10.603 58.537 1.00 22.11 O ATOM 564 CB SER A 416 32.104 8.071 58.595 1.00 20.13 C ATOM 565 OG SER A 416 30.849 8.586 58.219 1.00 23.54 O ATOM 566 N SER A 417 32.172 11.203 60.062 1.00 20.19 N ATOM 567 CA SER A 417 32.251 12.649 59.827 1.00 21.11 C ATOM 568 C SER A 417 31.989 13.438 61.121 1.00 21.46 C ATOM 569 O SER A 417 31.410 12.915 62.072 1.00 19.39 O ATOM 570 CB SER A 417 31.240 13.086 58.728 1.00 19.86 C ATOM 571 OG SER A 417 29.954 13.459 59.255 1.00 18.95 O ATOM 572 N GLU A 418 32.432 14.698 61.135 1.00 23.62 N ATOM 573 CA GLU A 418 31.834 15.727 62.010 1.00 23.16 C ATOM 574 C GLU A 418 30.422 16.059 61.587 1.00 22.01 C ATOM 575 O GLU A 418 29.993 15.732 60.483 1.00 18.72 O ATOM 576 CB GLU A 418 32.639 17.019 62.001 1.00 25.10 C ATOM 577 CG GLU A 418 33.932 16.915 62.765 1.00 28.60 C ATOM 578 CD GLU A 418 34.726 18.210 62.734 1.00 35.33 C ATOM 579 OE1 GLU A 418 34.108 19.298 62.876 1.00 40.85 O ATOM 580 OE2 GLU A 418 35.958 18.127 62.562 1.00 36.56 O ATOM 581 N SER A 419 29.700 16.732 62.469 1.00 20.29 N ATOM 582 CA SER A 419 28.313 17.084 62.188 1.00 20.20 C ATOM 583 C SER A 419 28.287 18.100 61.059 1.00 21.52 C ATOM 584 O SER A 419 29.156 18.974 60.983 1.00 21.91 O ATOM 585 CB SER A 419 27.629 17.665 63.426 1.00 22.70 C ATOM 586 OG SER A 419 28.147 18.945 63.741 1.00 23.26 O ATOM 587 N HIS A 420 27.309 17.956 60.176 1.00 21.28 N ATOM 588 CA HIS A 420 27.086 18.913 59.103 1.00 24.14 C ATOM 589 C HIS A 420 25.739 19.603 59.298 1.00 21.89 C ATOM 590 O HIS A 420 24.757 18.964 59.650 1.00 22.03 O ATOM 591 CB HIS A 420 27.170 18.232 57.727 1.00 25.17 C ATOM 592 CG HIS A 420 26.844 19.152 56.602 1.00 31.70 C ATOM 593 ND1 HIS A 420 27.697 20.157 56.197 1.00 35.37 N ATOM 594 CD2 HIS A 420 25.735 19.264 55.829 1.00 35.11 C ATOM 595 CE1 HIS A 420 27.139 20.835 55.208 1.00 34.95 C ATOM 596 NE2 HIS A 420 25.951 20.309 54.961 1.00 35.88 N ATOM 597 N HIS A 421 25.729 20.914 59.069 1.00 24.56 N ATOM 598 CA HIS A 421 24.538 21.758 59.172 1.00 24.06 C ATOM 599 C HIS A 421 24.212 22.401 57.839 1.00 26.63 C ATOM 600 O HIS A 421 25.114 22.649 57.030 1.00 29.12 O ATOM 601 CB HIS A 421 24.790 22.896 60.143 1.00 27.17 C ATOM 602 CG HIS A 421 24.718 22.499 61.576 1.00 27.99 C ATOM 603 ND1 HIS A 421 23.608 22.739 62.354 1.00 30.06 N ATOM 604 CD2 HIS A 421 25.626 21.901 62.380 1.00 31.07 C ATOM 605 CE1 HIS A 421 23.832 22.289 63.574 1.00 32.15 C ATOM 606 NE2 HIS A 421 25.050 21.780 63.615 1.00 30.46 N ATOM 607 N GLY A 422 22.932 22.736 57.640 1.00 24.68 N ATOM 608 CA GLY A 422 22.479 23.412 56.424 1.00 24.92 C ATOM 609 C GLY A 422 22.154 22.483 55.274 1.00 24.34 C ATOM 610 O GLY A 422 21.889 22.945 54.146 1.00 21.98 O ATOM 611 N GLY A 423 22.186 21.176 55.548 1.00 23.93 N ATOM 612 CA GLY A 423 21.793 20.167 54.575 1.00 22.85 C ATOM 613 C GLY A 423 20.318 19.837 54.713 1.00 23.33 C ATOM 614 O GLY A 423 19.554 20.548 55.379 1.00 25.14 O ATOM 615 N SER A 424 19.913 18.747 54.090 1.00 20.96 N ATOM 616 CA SER A 424 18.509 18.358 54.107 1.00 22.13 C ATOM 617 C SER A 424 18.208 17.654 55.454 1.00 25.00 C ATOM 618 O SER A 424 18.812 16.619 55.759 1.00 24.14 O ATOM 619 CB SER A 424 18.196 17.452 52.921 1.00 22.48 C ATOM 620 OG SER A 424 18.263 18.192 51.689 1.00 18.40 O ATOM 621 N PRO A 425 17.277 18.214 56.248 1.00 24.88 N ATOM 622 CA PRO A 425 16.948 17.683 57.580 1.00 26.58 C ATOM 623 C PRO A 425 16.505 16.212 57.559 1.00 24.78 C ATOM 624 O PRO A 425 15.809 15.785 56.637 1.00 27.05 O ATOM 625 CB PRO A 425 15.792 18.568 58.046 1.00 27.24 C ATOM 626 CG PRO A 425 15.193 19.131 56.809 1.00 28.12 C ATOM 627 CD PRO A 425 16.287 19.210 55.787 1.00 26.32 C ATOM 628 N ILE A 426 16.900 15.456 58.580 1.00 20.17 N ATOM 629 CA ILE A 426 16.452 14.067 58.731 1.00 20.91 C ATOM 630 C ILE A 426 15.050 14.065 59.340 1.00 19.95 C ATOM 631 O ILE A 426 14.734 14.896 60.189 1.00 19.92 O ATOM 632 CB ILE A 426 17.406 13.261 59.631 1.00 20.90 C ATOM 633 CG1 ILE A 426 18.838 13.290 59.074 1.00 23.23 C ATOM 634 CG2 ILE A 426 16.896 11.833 59.840 1.00 19.90 C ATOM 635 CD1 ILE A 426 18.950 12.865 57.631 1.00 24.57 C ATOM 636 N HIS A 427 14.222 13.111 58.944 1.00 21.75 N ATOM 637 CA HIS A 427 12.869 13.034 59.439 1.00 22.44 C ATOM 638 C HIS A 427 12.790 12.379 60.806 1.00 20.07 C ATOM 639 O HIS A 427 12.077 11.411 60.990 1.00 19.86 O ATOM 640 CB HIS A 427 11.972 12.277 58.455 1.00 27.74 C ATOM 641 CG HIS A 427 10.524 12.626 58.593 1.00 35.08 C ATOM 642 ND1 HIS A 427 9.609 12.435 57.578 1.00 40.69 N ATOM 643 CD2 HIS A 427 9.840 13.196 59.616 1.00 37.42 C ATOM 644 CE1 HIS A 427 8.420 12.846 57.984 1.00 43.11 C ATOM 645 NE2 HIS A 427 8.535 13.314 59.215 1.00 39.38 N ATOM 646 N TRP A 428 13.515 12.915 61.762 1.00 17.13 N ATOM 647 CA TRP A 428 13.465 12.396 63.131 1.00 16.64 C ATOM 648 C TRP A 428 12.063 12.468 63.738 1.00 18.55 C ATOM 649 O TRP A 428 11.301 13.392 63.475 1.00 20.69 O ATOM 650 CB TRP A 428 14.432 13.170 64.012 1.00 16.06 C ATOM 651 CG TRP A 428 15.914 13.131 63.590 1.00 16.55 C ATOM 652 CD1 TRP A 428 16.716 14.201 63.392 1.00 15.87 C ATOM 653 CD2 TRP A 428 16.741 11.968 63.349 1.00 16.99 C ATOM 654 NE1 TRP A 428 17.973 13.794 63.052 1.00 17.74 N ATOM 655 CE2 TRP A 428 18.013 12.430 63.018 1.00 15.89 C ATOM 656 CE3 TRP A 428 16.519 10.592 63.397 1.00 15.15 C ATOM 657 CZ2 TRP A 428 19.056 11.574 62.697 1.00 15.52 C ATOM 658 CZ3 TRP A 428 17.561 9.748 63.100 1.00 14.83 C ATOM 659 CH2 TRP A 428 18.811 10.239 62.765 1.00 15.62 C ATOM 660 N VAL A 429 11.737 11.503 64.580 1.00 16.85 N ATOM 661 CA VAL A 429 10.588 11.623 65.472 1.00 19.72 C ATOM 662 C VAL A 429 11.059 12.424 66.673 1.00 19.68 C ATOM 663 O VAL A 429 11.915 11.977 67.429 1.00 17.88 O ATOM 664 CB VAL A 429 10.050 10.250 65.903 1.00 18.07 C ATOM 665 CG1 VAL A 429 9.090 10.377 67.099 1.00 18.20 C ATOM 666 CG2 VAL A 429 9.393 9.572 64.706 1.00 18.43 C ATOM 667 N LEU A 430 10.457 13.605 66.836 1.00 21.99 N ATOM 668 CA LEU A 430 10.907 14.596 67.792 1.00 24.52 C ATOM 669 C LEU A 430 10.086 14.466 69.052 1.00 24.45 C ATOM 670 O LEU A 430 8.872 14.732 69.041 1.00 24.04 O ATOM 671 CB LEU A 430 10.778 16.006 67.210 1.00 29.35 C ATOM 672 CG LEU A 430 11.294 16.146 65.762 1.00 31.87 C ATOM 673 CD1 LEU A 430 10.620 17.319 65.054 1.00 36.25 C ATOM 674 CD2 LEU A 430 12.812 16.257 65.730 1.00 32.96 C ATOM 675 N PRO A 431 10.730 14.026 70.141 1.00 23.54 N ATOM 676 CA PRO A 431 10.102 14.036 71.435 1.00 27.19 C ATOM 677 C PRO A 431 9.588 15.417 71.747 1.00 29.21 C ATOM 678 O PRO A 431 10.142 16.420 71.238 1.00 26.75 O ATOM 679 CB PRO A 431 11.245 13.687 72.384 1.00 26.61 C ATOM 680 CG PRO A 431 12.139 12.839 71.557 1.00 27.99 C ATOM 681 CD PRO A 431 12.100 13.496 70.211 1.00 25.99 C ATOM 682 N ALA A 432 8.543 15.451 72.571 1.00 31.86 N ATOM 683 CA ALA A 432 7.854 16.676 72.933 1.00 36.24 C ATOM 684 C ALA A 432 8.812 17.656 73.630 1.00 34.18 C ATOM 685 O ALA A 432 9.603 17.254 74.483 1.00 34.60 O ATOM 686 CB ALA A 432 6.662 16.353 73.811 1.00 34.13 C ATOM 687 N GLY A 433 8.753 18.928 73.220 1.00 34.32 N ATOM 688 CA GLY A 433 9.697 19.958 73.687 1.00 34.19 C ATOM 689 C GLY A 433 11.031 20.021 72.948 1.00 34.06 C ATOM 690 O GLY A 433 11.836 20.913 73.194 1.00 35.62 O ATOM 691 N MET A 434 11.271 19.074 72.037 1.00 31.34 N ATOM 692 CA MET A 434 12.477 19.049 71.238 1.00 30.13 C ATOM 693 C MET A 434 12.130 19.483 69.808 1.00 31.30 C ATOM 694 O MET A 434 11.157 18.990 69.205 1.00 32.93 O ATOM 695 CB MET A 434 13.046 17.635 71.236 1.00 31.70 C ATOM 696 CG MET A 434 14.563 17.547 71.260 1.00 35.88 C ATOM 697 SD MET A 434 15.146 15.828 71.236 1.00 36.25 S ATOM 698 CE MET A 434 15.074 15.451 72.988 1.00 35.27 C ATOM 699 N SER A 435 12.916 20.407 69.270 1.00 27.89 N ATOM 700 CA SER A 435 12.689 20.910 67.925 1.00 27.86 C ATOM 701 C SER A 435 13.629 20.268 66.912 1.00 26.43 C ATOM 702 O SER A 435 14.662 19.684 67.287 1.00 29.16 O ATOM 703 CB SER A 435 12.903 22.413 67.921 1.00 27.49 C ATOM 704 OG SER A 435 14.258 22.712 68.202 1.00 24.65 O ATOM 705 N ALA A 436 13.288 20.377 65.625 1.00 25.77 N ATOM 706 CA ALA A 436 14.200 19.957 64.561 1.00 24.42 C ATOM 707 C ALA A 436 15.562 20.702 64.668 1.00 25.70 C ATOM 708 O ALA A 436 16.621 20.124 64.446 1.00 23.94 O ATOM 709 CB ALA A 436 13.563 20.204 63.212 1.00 25.91 C ATOM 710 N LYS A 437 15.530 21.980 65.036 1.00 26.85 N ATOM 711 CA LYS A 437 16.763 22.778 65.131 1.00 26.01 C ATOM 712 C LYS A 437 17.749 22.176 66.123 1.00 25.71 C ATOM 713 O LYS A 437 18.978 22.188 65.881 1.00 27.74 O ATOM 714 CB LYS A 437 16.462 24.249 65.501 1.00 25.69 C ATOM 715 N MET A 438 17.236 21.660 67.241 1.00 24.11 N ATOM 716 CA MET A 438 18.092 21.010 68.233 1.00 25.11 C ATOM 717 C MET A 438 18.841 19.752 67.699 1.00 24.51 C ATOM 718 O MET A 438 19.911 19.406 68.207 1.00 23.61 O ATOM 719 CB MET A 438 17.269 20.644 69.471 1.00 27.48 C ATOM 720 CG MET A 438 16.766 21.833 70.254 1.00 27.54 C ATOM 721 SD MET A 438 15.748 21.261 71.623 1.00 30.28 S ATOM 722 CE MET A 438 14.792 22.742 71.965 1.00 31.80 C ATOM 723 N LEU A 439 18.264 19.071 66.700 1.00 25.27 N ATOM 724 CA LEU A 439 18.929 17.903 66.062 1.00 25.19 C ATOM 725 C LEU A 439 19.260 18.176 64.586 1.00 27.03 C ATOM 726 O LEU A 439 19.143 17.276 63.729 1.00 27.21 O ATOM 727 CB LEU A 439 18.046 16.660 66.167 1.00 23.52 C ATOM 728 CG LEU A 439 17.490 16.378 67.553 1.00 23.41 C ATOM 729 CD1 LEU A 439 16.324 15.394 67.445 1.00 25.40 C ATOM 730 CD2 LEU A 439 18.570 15.828 68.452 1.00 22.85 C ATOM 731 N GLY A 440 19.667 19.411 64.287 1.00 28.33 N ATOM 732 CA GLY A 440 19.993 19.809 62.909 1.00 27.22 C ATOM 733 C GLY A 440 21.430 19.481 62.517 1.00 27.33 C ATOM 734 O GLY A 440 21.801 19.599 61.335 1.00 27.37 O ATOM 735 N GLY A 441 22.247 19.089 63.502 1.00 24.17 N ATOM 736 CA GLY A 441 23.621 18.615 63.235 1.00 25.66 C ATOM 737 C GLY A 441 23.554 17.159 62.799 1.00 24.35 C ATOM 738 O GLY A 441 23.083 16.310 63.558 1.00 21.03 O ATOM 739 N VAL A 442 23.963 16.878 61.555 1.00 21.65 N ATOM 740 CA VAL A 442 23.901 15.530 61.033 1.00 18.38 C ATOM 741 C VAL A 442 25.288 14.918 60.897 1.00 18.32 C ATOM 742 O VAL A 442 26.109 15.431 60.170 1.00 18.97 O ATOM 743 CB VAL A 442 23.175 15.436 59.675 1.00 19.44 C ATOM 744 CG1 VAL A 442 23.142 13.977 59.227 1.00 18.94 C ATOM 745 CG2 VAL A 442 21.754 16.001 59.767 1.00 19.69 C ATOM 746 N PHE A 443 25.518 13.815 61.621 1.00 16.65 N ATOM 747 CA PHE A 443 26.772 13.078 61.615 1.00 16.04 C ATOM 748 C PHE A 443 26.587 11.880 60.698 1.00 16.51 C ATOM 749 O PHE A 443 25.565 11.207 60.779 1.00 14.68 O ATOM 750 CB PHE A 443 27.074 12.480 63.002 1.00 16.71 C ATOM 751 CG PHE A 443 27.502 13.484 64.063 1.00 17.42 C ATOM 752 CD1 PHE A 443 26.552 14.096 64.901 1.00 19.23 C ATOM 753 CD2 PHE A 443 28.869 13.772 64.273 1.00 18.48 C ATOM 754 CE1 PHE A 443 26.955 14.992 65.910 1.00 18.84 C ATOM 755 CE2 PHE A 443 29.272 14.662 65.285 1.00 19.76 C ATOM 756 CZ PHE A 443 28.305 15.273 66.097 1.00 18.02 C ATOM 757 N LYS A 444 27.580 11.570 59.875 1.00 15.97 N ATOM 758 CA LYS A 444 27.581 10.288 59.181 1.00 17.31 C ATOM 759 C LYS A 444 28.200 9.237 60.081 1.00 15.42 C ATOM 760 O LYS A 444 29.149 9.524 60.789 1.00 15.35 O ATOM 761 CB LYS A 444 28.330 10.373 57.871 1.00 20.24 C ATOM 762 CG LYS A 444 27.644 11.282 56.884 1.00 23.42 C ATOM 763 CD LYS A 444 28.332 11.251 55.524 1.00 29.59 C ATOM 764 CE LYS A 444 27.762 12.304 54.599 1.00 33.15 C ATOM 765 NZ LYS A 444 28.577 12.413 53.364 1.00 37.10 N ATOM 766 N ILE A 445 27.625 8.032 60.076 1.00 15.33 N ATOM 767 CA ILE A 445 28.157 6.917 60.828 1.00 16.52 C ATOM 768 C ILE A 445 28.187 5.639 60.008 1.00 16.59 C ATOM 769 O ILE A 445 27.383 5.447 59.116 1.00 15.78 O ATOM 770 CB ILE A 445 27.351 6.670 62.114 1.00 16.51 C ATOM 771 CG1 ILE A 445 25.906 6.214 61.774 1.00 16.65 C ATOM 772 CG2 ILE A 445 27.326 7.957 62.949 1.00 16.04 C ATOM 773 CD1 ILE A 445 25.047 5.876 62.975 1.00 17.85 C ATOM 774 N ASP A 446 29.124 4.762 60.350 1.00 17.72 N ATOM 775 CA ASP A 446 29.232 3.437 59.757 1.00 17.24 C ATOM 776 C ASP A 446 28.966 2.456 60.873 1.00 16.04 C ATOM 777 O ASP A 446 29.699 2.420 61.887 1.00 18.28 O ATOM 778 CB ASP A 446 30.630 3.203 59.183 1.00 18.66 C ATOM 779 CG ASP A 446 30.905 4.058 57.966 1.00 25.62 C ATOM 780 OD1 ASP A 446 30.067 4.011 57.020 1.00 31.87 O ATOM 781 OD2 ASP A 446 31.938 4.786 57.954 1.00 28.34 O ATOM 782 N TRP A 447 27.915 1.681 60.714 1.00 15.27 N ATOM 783 CA TRP A 447 27.577 0.693 61.726 1.00 14.04 C ATOM 784 C TRP A 447 28.650 -0.382 61.824 1.00 14.71 C ATOM 785 O TRP A 447 29.189 -0.849 60.813 1.00 15.35 O ATOM 786 CB TRP A 447 26.220 0.104 61.436 1.00 13.97 C ATOM 787 CG TRP A 447 25.188 1.100 61.763 1.00 13.31 C ATOM 788 CD1 TRP A 447 24.655 2.055 60.930 1.00 13.50 C ATOM 789 CD2 TRP A 447 24.654 1.340 63.067 1.00 11.76 C ATOM 790 NE1 TRP A 447 23.772 2.848 61.645 1.00 13.13 N ATOM 791 CE2 TRP A 447 23.761 2.429 62.959 1.00 11.58 C ATOM 792 CE3 TRP A 447 24.822 0.705 64.308 1.00 11.54 C ATOM 793 CZ2 TRP A 447 23.022 2.897 64.043 1.00 11.67 C ATOM 794 CZ3 TRP A 447 24.126 1.139 65.366 1.00 12.33 C ATOM 795 CH2 TRP A 447 23.217 2.263 65.249 1.00 12.25 C ATOM 796 N ILE A 448 28.982 -0.729 63.063 1.00 15.10 N ATOM 797 CA ILE A 448 29.932 -1.811 63.361 1.00 17.51 C ATOM 798 C ILE A 448 29.161 -3.037 63.810 1.00 16.84 C ATOM 799 O ILE A 448 29.557 -4.166 63.533 1.00 16.80 O ATOM 800 CB ILE A 448 30.982 -1.391 64.430 1.00 19.64 C ATOM 801 CG1 ILE A 448 31.830 -0.229 63.902 1.00 22.90 C ATOM 802 CG2 ILE A 448 31.886 -2.567 64.802 1.00 18.59 C ATOM 803 CD1 ILE A 448 32.424 0.619 64.986 1.00 24.30 C ATOM 804 N CYS A 449 28.034 -2.816 64.466 1.00 15.23 N ATOM 805 CA CYS A 449 27.231 -3.912 64.922 1.00 16.38 C ATOM 806 C CYS A 449 25.827 -3.404 65.078 1.00 16.64 C ATOM 807 O CYS A 449 25.597 -2.481 65.863 1.00 16.82 O ATOM 808 CB CYS A 449 27.768 -4.417 66.259 1.00 17.59 C ATOM 809 SG CYS A 449 26.730 -5.669 67.008 1.00 20.05 S ATOM 810 N ARG A 450 24.891 -3.986 64.313 1.00 15.78 N ATOM 811 CA ARG A 450 23.475 -3.656 64.420 1.00 16.45 C ATOM 812 C ARG A 450 22.704 -4.606 65.350 1.00 17.24 C ATOM 813 O ARG A 450 21.494 -4.445 65.537 1.00 16.63 O ATOM 814 CB ARG A 450 22.817 -3.638 63.036 1.00 16.54 C ATOM 815 CG ARG A 450 23.255 -2.512 62.135 1.00 17.85 C ATOM 816 CD ARG A 450 22.296 -2.330 60.947 1.00 20.00 C ATOM 817 NE ARG A 450 22.762 -1.261 60.051 1.00 21.94 N ATOM 818 CZ ARG A 450 23.867 -1.351 59.293 1.00 22.40 C ATOM 819 NH1 ARG A 450 24.598 -2.455 59.300 1.00 22.48 N ATOM 820 NH2 ARG A 450 24.251 -0.327 58.527 1.00 25.99 N ATOM 821 N ARG A 451 23.406 -5.565 65.942 1.00 17.69 N ATOM 822 CA ARG A 451 22.822 -6.506 66.892 1.00 18.20 C ATOM 823 C ARG A 451 22.668 -5.888 68.273 1.00 19.14 C ATOM 824 O ARG A 451 23.455 -5.034 68.661 1.00 16.35 O ATOM 825 CB ARG A 451 23.720 -7.756 67.023 1.00 20.65 C ATOM 826 CG ARG A 451 23.975 -8.519 65.718 1.00 21.77 C ATOM 827 CD ARG A 451 22.809 -9.363 65.313 1.00 25.95 C ATOM 828 NE ARG A 451 22.508 -10.370 66.340 1.00 28.25 N ATOM 829 CZ ARG A 451 23.102 -11.565 66.448 1.00 30.63 C ATOM 830 NH1 ARG A 451 24.061 -11.953 65.600 1.00 32.39 N ATOM 831 NH2 ARG A 451 22.735 -12.386 67.426 1.00 30.55 N ATOM 832 N GLU A 452 21.670 -6.370 69.011 1.00 17.80 N ATOM 833 CA GLU A 452 21.334 -5.857 70.349 1.00 19.87 C ATOM 834 C GLU A 452 22.092 -6.589 71.443 1.00 18.16 C ATOM 835 O GLU A 452 22.664 -7.661 71.218 1.00 18.09 O ATOM 836 CB GLU A 452 19.843 -6.011 70.661 1.00 21.56 C ATOM 837 CG GLU A 452 18.877 -5.260 69.758 1.00 28.84 C ATOM 838 CD GLU A 452 17.430 -5.460 70.185 1.00 32.35 C ATOM 839 OE1 GLU A 452 17.124 -6.435 70.938 1.00 35.51 O ATOM 840 OE2 GLU A 452 16.600 -4.633 69.774 1.00 40.22 O ATOM 841 N LEU A 453 22.116 -5.964 72.617 1.00 18.15 N ATOM 842 CA LEU A 453 22.714 -6.535 73.802 1.00 18.52 C ATOM 843 C LEU A 453 21.873 -6.080 74.982 1.00 18.42 C ATOM 844 O LEU A 453 21.830 -4.889 75.305 1.00 18.79 O ATOM 845 CB LEU A 453 24.192 -6.105 73.980 1.00 18.23 C ATOM 846 CG LEU A 453 24.942 -6.684 75.213 1.00 17.45 C ATOM 847 CD1 LEU A 453 25.476 -8.078 74.918 1.00 17.90 C ATOM 848 CD2 LEU A 453 26.106 -5.804 75.597 1.00 17.15 C ATOM 849 N PRO A 454 21.180 -7.029 75.629 1.00 19.93 N ATOM 850 CA PRO A 454 20.408 -6.742 76.824 1.00 20.13 C ATOM 851 C PRO A 454 21.305 -6.246 77.935 1.00 17.58 C ATOM 852 O PRO A 454 22.411 -6.741 78.075 1.00 18.52 O ATOM 853 CB PRO A 454 19.832 -8.122 77.213 1.00 21.71 C ATOM 854 CG PRO A 454 19.814 -8.896 75.952 1.00 24.47 C ATOM 855 CD PRO A 454 20.987 -8.414 75.156 1.00 20.78 C ATOM 856 N PHE A 455 20.826 -5.307 78.738 1.00 16.87 N ATOM 857 CA PHE A 455 21.632 -4.797 79.848 1.00 15.88 C ATOM 858 C PHE A 455 22.094 -5.913 80.810 1.00 15.46 C ATOM 859 O PHE A 455 23.132 -5.788 81.427 1.00 15.51 O ATOM 860 CB PHE A 455 20.891 -3.757 80.682 1.00 14.69 C ATOM 861 CG PHE A 455 20.655 -2.430 79.998 1.00 13.47 C ATOM 862 CD1 PHE A 455 21.460 -1.958 78.987 1.00 13.08 C ATOM 863 CD2 PHE A 455 19.642 -1.616 80.458 1.00 12.86 C ATOM 864 CE1 PHE A 455 21.227 -0.734 78.418 1.00 12.89 C ATOM 865 CE2 PHE A 455 19.390 -0.392 79.875 1.00 13.10 C ATOM 866 CZ PHE A 455 20.190 0.063 78.869 1.00 13.57 C ATOM 867 N THR A 456 21.329 -6.986 80.933 1.00 14.99 N ATOM 868 CA THR A 456 21.723 -8.093 81.824 1.00 16.15 C ATOM 869 C THR A 456 23.082 -8.685 81.489 1.00 16.48 C ATOM 870 O THR A 456 23.757 -9.168 82.373 1.00 14.75 O ATOM 871 CB THR A 456 20.692 -9.230 81.821 1.00 16.76 C ATOM 872 OG1 THR A 456 20.508 -9.693 80.487 1.00 15.05 O ATOM 873 CG2 THR A 456 19.380 -8.746 82.353 1.00 18.38 C ATOM 874 N LYS A 457 23.503 -8.603 80.224 1.00 16.73 N ATOM 875 CA LYS A 457 24.774 -9.140 79.808 1.00 17.90 C ATOM 876 C LYS A 457 25.956 -8.209 80.083 1.00 17.29 C ATOM 877 O LYS A 457 27.111 -8.642 79.998 1.00 18.27 O ATOM 878 CB LYS A 457 24.744 -9.439 78.301 1.00 19.61 C ATOM 879 CG LYS A 457 23.709 -10.465 77.883 1.00 22.61 C ATOM 880 CD LYS A 457 23.919 -11.812 78.553 1.00 23.63 C ATOM 881 CE LYS A 457 22.920 -12.845 78.075 1.00 26.29 C ATOM 882 NZ LYS A 457 23.034 -12.967 76.616 1.00 27.74 N ATOM 883 N SER A 458 25.682 -6.944 80.397 1.00 16.38 N ATOM 884 CA SER A 458 26.730 -6.000 80.751 1.00 15.83 C ATOM 885 C SER A 458 26.721 -5.626 82.250 1.00 15.00 C ATOM 886 O SER A 458 27.398 -4.697 82.628 1.00 14.30 O ATOM 887 CB SER A 458 26.595 -4.722 79.914 1.00 16.15 C ATOM 888 OG SER A 458 25.406 -4.009 80.257 1.00 16.21 O ATOM 889 N ALA A 459 25.973 -6.347 83.082 1.00 17.18 N ATOM 890 CA ALA A 459 25.812 -5.962 84.515 1.00 18.03 C ATOM 891 C ALA A 459 27.104 -5.911 85.325 1.00 18.08 C ATOM 892 O ALA A 459 27.207 -5.223 86.338 1.00 20.64 O ATOM 893 CB ALA A 459 24.815 -6.886 85.191 1.00 18.70 C ATOM 894 N HIS A 460 28.077 -6.688 84.909 1.00 19.83 N ATOM 895 CA HIS A 460 29.388 -6.723 85.560 1.00 18.70 C ATOM 896 C HIS A 460 30.308 -5.527 85.207 1.00 19.13 C ATOM 897 O HIS A 460 31.294 -5.306 85.884 1.00 23.29 O ATOM 898 CB HIS A 460 30.090 -8.053 85.208 1.00 17.81 C ATOM 899 CG HIS A 460 30.371 -8.199 83.750 1.00 16.72 C ATOM 900 ND1 HIS A 460 29.393 -8.508 82.833 1.00 17.17 N ATOM 901 CD2 HIS A 460 31.505 -8.024 83.038 1.00 18.23 C ATOM 902 CE1 HIS A 460 29.905 -8.525 81.619 1.00 17.49 C ATOM 903 NE2 HIS A 460 31.191 -8.251 81.714 1.00 18.56 N ATOM 904 N LEU A 461 29.998 -4.788 84.135 1.00 17.52 N ATOM 905 CA LEU A 461 30.808 -3.646 83.664 1.00 14.78 C ATOM 906 C LEU A 461 30.347 -2.344 84.338 1.00 16.58 C ATOM 907 O LEU A 461 29.151 -1.985 84.275 1.00 15.37 O ATOM 908 CB LEU A 461 30.699 -3.498 82.125 1.00 14.03 C ATOM 909 CG LEU A 461 31.341 -4.571 81.256 1.00 15.19 C ATOM 910 CD1 LEU A 461 31.283 -4.184 79.761 1.00 15.67 C ATOM 911 CD2 LEU A 461 32.764 -4.814 81.699 1.00 14.78 C ATOM 912 N THR A 462 31.282 -1.644 84.984 1.00 16.39 N ATOM 913 CA THR A 462 31.020 -0.333 85.590 1.00 18.43 C ATOM 914 C THR A 462 31.893 0.691 84.886 1.00 17.08 C ATOM 915 O THR A 462 32.908 0.339 84.322 1.00 17.74 O ATOM 916 CB THR A 462 31.345 -0.291 87.105 1.00 20.07 C ATOM 917 OG1 THR A 462 32.693 -0.696 87.313 1.00 22.43 O ATOM 918 CG2 THR A 462 30.406 -1.177 87.916 1.00 23.90 C ATOM 919 N ASN A 463 31.451 1.945 84.890 1.00 15.43 N ATOM 920 CA ASN A 463 32.074 3.014 84.120 1.00 14.56 C ATOM 921 C ASN A 463 32.744 4.016 85.078 1.00 13.92 C ATOM 922 O ASN A 463 32.045 4.818 85.728 1.00 12.54 O ATOM 923 CB ASN A 463 31.000 3.696 83.268 1.00 14.07 C ATOM 924 CG ASN A 463 31.533 4.835 82.408 1.00 13.30 C ATOM 925 OD1 ASN A 463 32.721 5.088 82.331 1.00 11.26 O ATOM 926 ND2 ASN A 463 30.612 5.525 81.734 1.00 12.52 N ATOM 927 N PRO A 464 34.095 3.970 85.173 1.00 13.04 N ATOM 928 CA PRO A 464 34.830 4.851 86.070 1.00 14.59 C ATOM 929 C PRO A 464 34.581 6.307 85.788 1.00 14.22 C ATOM 930 O PRO A 464 34.768 7.104 86.677 1.00 17.17 O ATOM 931 CB PRO A 464 36.310 4.552 85.797 1.00 14.32 C ATOM 932 CG PRO A 464 36.355 3.306 85.044 1.00 15.75 C ATOM 933 CD PRO A 464 34.998 3.073 84.431 1.00 14.45 C ATOM 934 N TRP A 465 34.152 6.648 84.578 1.00 13.64 N ATOM 935 CA TRP A 465 33.826 8.059 84.277 1.00 13.64 C ATOM 936 C TRP A 465 32.373 8.432 84.559 1.00 14.35 C ATOM 937 O TRP A 465 31.982 9.584 84.281 1.00 14.65 O ATOM 938 CB TRP A 465 34.233 8.409 82.836 1.00 13.36 C ATOM 939 CG TRP A 465 35.706 8.192 82.550 1.00 12.95 C ATOM 940 CD1 TRP A 465 36.706 7.998 83.455 1.00 13.08 C ATOM 941 CD2 TRP A 465 36.319 8.165 81.255 1.00 12.65 C ATOM 942 NE1 TRP A 465 37.906 7.836 82.797 1.00 13.01 N ATOM 943 CE2 TRP A 465 37.686 7.938 81.442 1.00 13.06 C ATOM 944 CE3 TRP A 465 35.835 8.315 79.951 1.00 12.02 C ATOM 945 CZ2 TRP A 465 38.575 7.844 80.370 1.00 12.47 C ATOM 946 CZ3 TRP A 465 36.716 8.215 78.890 1.00 14.23 C ATOM 947 CH2 TRP A 465 38.069 7.996 79.103 1.00 12.54 C ATOM 948 N ASN A 466 31.574 7.490 85.103 1.00 12.95 N ATOM 949 CA ASN A 466 30.263 7.818 85.662 1.00 12.99 C ATOM 950 C ASN A 466 30.063 7.286 87.083 1.00 14.40 C ATOM 951 O ASN A 466 29.123 6.498 87.365 1.00 14.26 O ATOM 952 CB ASN A 466 29.143 7.327 84.757 1.00 13.16 C ATOM 953 CG ASN A 466 27.837 8.020 85.059 1.00 12.37 C ATOM 954 OD1 ASN A 466 27.850 9.126 85.559 1.00 13.68 O ATOM 955 ND2 ASN A 466 26.722 7.366 84.813 1.00 13.30 N ATOM 956 N GLU A 467 30.956 7.686 87.970 1.00 14.71 N ATOM 957 CA GLU A 467 30.895 7.289 89.378 1.00 17.15 C ATOM 958 C GLU A 467 30.880 5.786 89.578 1.00 16.66 C ATOM 959 O GLU A 467 30.353 5.283 90.600 1.00 16.28 O ATOM 960 CB GLU A 467 29.662 7.879 90.024 1.00 18.27 C ATOM 961 CG GLU A 467 29.561 9.370 89.838 1.00 20.74 C ATOM 962 CD GLU A 467 28.342 9.943 90.525 1.00 23.68 C ATOM 963 OE1 GLU A 467 28.160 9.637 91.716 1.00 26.91 O ATOM 964 OE2 GLU A 467 27.592 10.703 89.893 1.00 27.33 O ATOM 965 N HIS A 468 31.447 5.047 88.627 1.00 17.71 N ATOM 966 CA HIS A 468 31.542 3.584 88.743 1.00 18.37 C ATOM 967 C HIS A 468 30.160 2.910 88.784 1.00 19.82 C ATOM 968 O HIS A 468 30.003 1.787 89.281 1.00 20.13 O ATOM 969 CB HIS A 468 32.395 3.191 89.960 1.00 20.21 C ATOM 970 CG HIS A 468 33.796 3.723 89.902 1.00 19.19 C ATOM 971 ND1 HIS A 468 34.801 3.085 89.214 1.00 21.64 N ATOM 972 CD2 HIS A 468 34.348 4.841 90.426 1.00 20.94 C ATOM 973 CE1 HIS A 468 35.920 3.780 89.327 1.00 22.57 C ATOM 974 NE2 HIS A 468 35.667 4.858 90.048 1.00 22.19 N ATOM 975 N LYS A 469 29.166 3.603 88.222 1.00 17.96 N ATOM 976 CA LYS A 469 27.862 3.042 88.017 1.00 17.39 C ATOM 977 C LYS A 469 27.959 2.004 86.921 1.00 15.32 C ATOM 978 O LYS A 469 28.800 2.111 86.047 1.00 15.77 O ATOM 979 CB LYS A 469 26.855 4.119 87.607 1.00 17.99 C ATOM 980 CG LYS A 469 26.489 5.101 88.720 1.00 19.15 C ATOM 981 CD LYS A 469 25.743 6.278 88.162 1.00 20.30 C ATOM 982 CE LYS A 469 25.293 7.184 89.279 1.00 22.42 C ATOM 983 NZ LYS A 469 24.358 8.189 88.712 1.00 23.69 N ATOM 984 N PRO A 470 27.092 0.975 86.968 1.00 13.67 N ATOM 985 CA PRO A 470 26.992 0.032 85.862 1.00 12.63 C ATOM 986 C PRO A 470 26.863 0.756 84.510 1.00 11.33 C ATOM 987 O PRO A 470 26.136 1.733 84.435 1.00 10.79 O ATOM 988 CB PRO A 470 25.682 -0.706 86.169 1.00 12.65 C ATOM 989 CG PRO A 470 25.581 -0.682 87.687 1.00 14.75 C ATOM 990 CD PRO A 470 26.360 0.521 88.164 1.00 14.79 C ATOM 991 N VAL A 471 27.530 0.246 83.486 1.00 11.09 N ATOM 992 CA VAL A 471 27.645 0.949 82.190 1.00 12.54 C ATOM 993 C VAL A 471 26.313 1.300 81.528 1.00 12.65 C ATOM 994 O VAL A 471 26.240 2.273 80.762 1.00 12.88 O ATOM 995 CB VAL A 471 28.587 0.222 81.184 1.00 13.00 C ATOM 996 CG1 VAL A 471 27.974 -1.056 80.671 1.00 13.56 C ATOM 997 CG2 VAL A 471 28.923 1.141 80.020 1.00 12.76 C ATOM 998 N LYS A 472 25.266 0.506 81.804 1.00 13.73 N ATOM 999 CA LYS A 472 23.903 0.783 81.358 1.00 16.06 C ATOM 1000 C LYS A 472 23.332 2.130 81.829 1.00 16.87 C ATOM 1001 O LYS A 472 22.385 2.657 81.201 1.00 19.54 O ATOM 1002 CB LYS A 472 22.948 -0.333 81.838 1.00 14.95 C ATOM 1003 CG LYS A 472 22.704 -0.352 83.358 1.00 13.43 C ATOM 1004 CD LYS A 472 21.443 -1.118 83.689 1.00 13.63 C ATOM 1005 CE LYS A 472 21.286 -1.365 85.182 1.00 15.35 C ATOM 1006 NZ LYS A 472 19.842 -1.501 85.559 1.00 15.73 N ATOM 1007 N ILE A 473 23.869 2.656 82.940 1.00 16.36 N ATOM 1008 CA ILE A 473 23.404 3.904 83.518 1.00 14.88 C ATOM 1009 C ILE A 473 24.258 5.008 82.920 1.00 15.66 C ATOM 1010 O ILE A 473 25.507 4.938 82.947 1.00 14.61 O ATOM 1011 CB ILE A 473 23.520 3.918 85.051 1.00 14.29 C ATOM 1012 CG1 ILE A 473 22.826 2.698 85.646 1.00 14.79 C ATOM 1013 CG2 ILE A 473 22.951 5.213 85.604 1.00 14.60 C ATOM 1014 CD1 ILE A 473 22.640 2.795 87.154 1.00 15.13 C ATOM 1015 N GLY A 474 23.597 5.999 82.336 1.00 16.73 N ATOM 1016 CA GLY A 474 24.303 7.072 81.625 1.00 15.81 C ATOM 1017 C GLY A 474 23.352 7.909 80.808 1.00 15.06 C ATOM 1018 O GLY A 474 22.438 7.375 80.180 1.00 14.27 O ATOM 1019 N ARG A 475 23.542 9.225 80.843 1.00 13.23 N ATOM 1020 CA ARG A 475 22.741 10.143 80.030 1.00 14.77 C ATOM 1021 C ARG A 475 23.232 10.043 78.569 1.00 12.64 C ATOM 1022 O ARG A 475 24.313 9.506 78.323 1.00 13.12 O ATOM 1023 CB ARG A 475 22.945 11.570 80.526 1.00 17.60 C ATOM 1024 CG ARG A 475 22.378 11.856 81.903 1.00 21.00 C ATOM 1025 CD ARG A 475 20.890 12.143 81.819 1.00 25.41 C ATOM 1026 NE ARG A 475 20.355 12.566 83.112 1.00 28.20 N ATOM 1027 CZ ARG A 475 19.108 12.970 83.318 1.00 33.53 C ATOM 1028 NH1 ARG A 475 18.737 13.324 84.548 1.00 33.08 N ATOM 1029 NH2 ARG A 475 18.232 13.021 82.309 1.00 27.89 N ATOM 1030 N ASP A 476 22.466 10.560 77.623 1.00 12.47 N ATOM 1031 CA ASP A 476 22.935 10.705 76.211 1.00 12.68 C ATOM 1032 C ASP A 476 24.277 11.468 76.233 1.00 13.23 C ATOM 1033 O ASP A 476 24.388 12.494 76.911 1.00 12.53 O ATOM 1034 CB ASP A 476 21.896 11.480 75.426 1.00 12.64 C ATOM 1035 CG ASP A 476 22.225 11.654 73.914 1.00 12.50 C ATOM 1036 OD1 ASP A 476 22.619 10.713 73.201 1.00 11.72 O ATOM 1037 OD2 ASP A 476 22.026 12.802 73.447 1.00 12.79 O ATOM 1038 N GLY A 477 25.279 10.912 75.556 1.00 12.94 N ATOM 1039 CA GLY A 477 26.598 11.545 75.397 1.00 13.37 C ATOM 1040 C GLY A 477 27.608 11.241 76.494 1.00 14.08 C ATOM 1041 O GLY A 477 28.706 11.776 76.477 1.00 12.70 O ATOM 1042 N GLN A 478 27.230 10.412 77.458 1.00 13.18 N ATOM 1043 CA GLN A 478 28.119 10.056 78.540 1.00 14.22 C ATOM 1044 C GLN A 478 29.278 9.303 77.950 1.00 13.38 C ATOM 1045 O GLN A 478 29.088 8.341 77.191 1.00 13.50 O ATOM 1046 CB GLN A 478 27.411 9.180 79.563 1.00 15.22 C ATOM 1047 CG GLN A 478 28.353 8.477 80.540 1.00 15.79 C ATOM 1048 CD GLN A 478 28.948 9.435 81.530 1.00 17.20 C ATOM 1049 OE1 GLN A 478 28.221 10.052 82.317 1.00 17.98 O ATOM 1050 NE2 GLN A 478 30.268 9.592 81.494 1.00 16.00 N ATOM 1051 N GLU A 479 30.496 9.759 78.249 1.00 12.98 N ATOM 1052 CA GLU A 479 31.647 9.076 77.704 1.00 13.89 C ATOM 1053 C GLU A 479 31.921 7.845 78.546 1.00 13.30 C ATOM 1054 O GLU A 479 31.772 7.850 79.808 1.00 12.23 O ATOM 1055 CB GLU A 479 32.880 9.959 77.592 1.00 14.52 C ATOM 1056 CG GLU A 479 33.885 9.318 76.627 1.00 14.97 C ATOM 1057 CD GLU A 479 35.072 10.174 76.292 1.00 15.13 C ATOM 1058 OE1 GLU A 479 35.036 11.404 76.538 1.00 14.48 O ATOM 1059 OE2 GLU A 479 36.065 9.576 75.814 1.00 15.55 O ATOM 1060 N ILE A 480 32.303 6.783 77.863 1.00 12.54 N ATOM 1061 CA ILE A 480 32.638 5.534 78.552 1.00 13.61 C ATOM 1062 C ILE A 480 34.132 5.340 78.529 1.00 14.54 C ATOM 1063 O ILE A 480 34.766 5.451 77.474 1.00 13.74 O ATOM 1064 CB ILE A 480 31.934 4.326 77.923 1.00 12.96 C ATOM 1065 CG1 ILE A 480 30.410 4.548 77.952 1.00 12.94 C ATOM 1066 CG2 ILE A 480 32.253 3.057 78.677 1.00 13.09 C ATOM 1067 CD1 ILE A 480 29.709 3.613 77.023 1.00 12.37 C ATOM 1068 N GLU A 481 34.685 5.100 79.726 1.00 14.89 N ATOM 1069 CA GLU A 481 36.129 4.837 79.870 1.00 15.64 C ATOM 1070 C GLU A 481 36.606 3.699 78.928 1.00 15.62 C ATOM 1071 O GLU A 481 35.854 2.773 78.612 1.00 13.93 O ATOM 1072 CB GLU A 481 36.434 4.551 81.351 1.00 16.65 C ATOM 1073 CG GLU A 481 37.880 4.271 81.719 1.00 18.41 C ATOM 1074 CD GLU A 481 38.236 2.801 81.715 1.00 20.70 C ATOM 1075 OE1 GLU A 481 37.329 1.952 81.910 1.00 24.47 O ATOM 1076 OE2 GLU A 481 39.438 2.496 81.492 1.00 22.80 O ATOM 1077 N LEU A 482 37.869 3.785 78.522 1.00 16.84 N ATOM 1078 CA LEU A 482 38.487 2.879 77.513 1.00 18.63 C ATOM 1079 C LEU A 482 38.260 1.372 77.727 1.00 19.21 C ATOM 1080 O LEU A 482 37.765 0.685 76.836 1.00 18.49 O ATOM 1081 CB LEU A 482 39.991 3.120 77.456 1.00 18.83 C ATOM 1082 CG LEU A 482 40.850 2.330 76.469 1.00 20.74 C ATOM 1083 CD1 LEU A 482 40.334 2.397 75.052 1.00 21.26 C ATOM 1084 CD2 LEU A 482 42.281 2.871 76.530 1.00 24.89 C ATOM 1085 N GLU A 483 38.623 0.874 78.909 1.00 20.30 N ATOM 1086 CA GLU A 483 38.520 -0.574 79.194 1.00 23.55 C ATOM 1087 C GLU A 483 37.049 -1.007 79.186 1.00 21.17 C ATOM 1088 O GLU A 483 36.672 -1.955 78.508 1.00 20.32 O ATOM 1089 CB GLU A 483 39.149 -0.917 80.554 1.00 25.59 C ATOM 1090 CG GLU A 483 40.627 -0.557 80.689 1.00 30.17 C ATOM 1091 CD GLU A 483 41.596 -1.508 79.979 1.00 33.64 C ATOM 1092 OE1 GLU A 483 41.160 -2.441 79.244 1.00 33.83 O ATOM 1093 OE2 GLU A 483 42.823 -1.311 80.174 1.00 39.21 O ATOM 1094 N CYS A 484 36.232 -0.290 79.940 1.00 19.25 N ATOM 1095 CA CYS A 484 34.798 -0.566 80.013 1.00 17.55 C ATOM 1096 C CYS A 484 34.147 -0.551 78.637 1.00 15.37 C ATOM 1097 O CYS A 484 33.383 -1.448 78.298 1.00 13.94 O ATOM 1098 CB CYS A 484 34.141 0.488 80.878 1.00 16.70 C ATOM 1099 SG CYS A 484 32.382 0.252 81.143 1.00 18.43 S ATOM 1100 N GLY A 485 34.398 0.506 77.872 1.00 15.30 N ATOM 1101 CA GLY A 485 33.881 0.606 76.496 1.00 15.61 C ATOM 1102 C GLY A 485 34.313 -0.510 75.558 1.00 16.45 C ATOM 1103 O GLY A 485 33.539 -1.021 74.733 1.00 18.03 O ATOM 1104 N THR A 486 35.577 -0.875 75.643 1.00 16.87 N ATOM 1105 CA THR A 486 36.106 -1.908 74.779 1.00 16.64 C ATOM 1106 C THR A 486 35.467 -3.231 75.116 1.00 14.94 C ATOM 1107 O THR A 486 35.015 -3.955 74.247 1.00 14.99 O ATOM 1108 CB THR A 486 37.635 -2.021 74.921 1.00 17.55 C ATOM 1109 OG1 THR A 486 38.243 -0.782 74.513 1.00 16.73 O ATOM 1110 CG2 THR A 486 38.171 -3.166 74.079 1.00 18.61 C ATOM 1111 N GLN A 487 35.398 -3.525 76.403 1.00 16.46 N ATOM 1112 CA GLN A 487 34.842 -4.776 76.866 1.00 16.90 C ATOM 1113 C GLN A 487 33.357 -4.825 76.572 1.00 16.18 C ATOM 1114 O GLN A 487 32.818 -5.885 76.194 1.00 14.90 O ATOM 1115 CB AGLN A 487 35.120 -4.982 78.374 0.50 17.67 C ATOM 1116 CB BGLN A 487 35.118 -4.957 78.377 0.50 18.36 C ATOM 1117 CG AGLN A 487 36.608 -5.114 78.736 0.50 18.11 C ATOM 1118 CG BGLN A 487 36.602 -5.159 78.701 0.50 19.44 C ATOM 1119 CD AGLN A 487 37.394 -6.006 77.786 0.50 18.77 C ATOM 1120 CD BGLN A 487 36.889 -5.152 80.190 0.50 20.98 C ATOM 1121 OE1AGLN A 487 36.930 -7.088 77.395 0.50 20.89 O ATOM 1122 OE1BGLN A 487 36.143 -5.712 80.971 0.50 23.23 O ATOM 1123 NE2AGLN A 487 38.604 -5.565 77.416 0.50 18.53 N ATOM 1124 NE2BGLN A 487 37.987 -4.516 80.582 0.50 22.17 N ATOM 1125 N LEU A 488 32.682 -3.683 76.678 1.00 15.73 N ATOM 1126 CA LEU A 488 31.271 -3.662 76.381 1.00 14.23 C ATOM 1127 C LEU A 488 31.028 -4.023 74.921 1.00 13.71 C ATOM 1128 O LEU A 488 30.255 -4.930 74.628 1.00 13.77 O ATOM 1129 CB LEU A 488 30.674 -2.287 76.678 1.00 15.12 C ATOM 1130 CG LEU A 488 29.211 -2.116 76.300 1.00 13.92 C ATOM 1131 CD1 LEU A 488 28.295 -3.159 76.931 1.00 14.30 C ATOM 1132 CD2 LEU A 488 28.748 -0.729 76.722 1.00 15.10 C ATOM 1133 N CYS A 489 31.664 -3.312 74.004 1.00 13.78 N ATOM 1134 CA CYS A 489 31.530 -3.620 72.571 1.00 14.46 C ATOM 1135 C CYS A 489 31.817 -5.080 72.246 1.00 16.46 C ATOM 1136 O CYS A 489 31.140 -5.683 71.393 1.00 16.10 O ATOM 1137 CB CYS A 489 32.451 -2.739 71.767 1.00 15.65 C ATOM 1138 SG CYS A 489 31.877 -1.035 71.652 1.00 16.82 S ATOM 1139 N LEU A 490 32.808 -5.655 72.930 1.00 17.16 N ATOM 1140 CA LEU A 490 33.159 -7.063 72.732 1.00 19.05 C ATOM 1141 C LEU A 490 32.053 -8.046 73.187 1.00 19.91 C ATOM 1142 O LEU A 490 31.974 -9.164 72.652 1.00 21.31 O ATOM 1143 CB LEU A 490 34.502 -7.397 73.403 1.00 18.93 C ATOM 1144 CG LEU A 490 35.754 -6.742 72.772 1.00 21.73 C ATOM 1145 CD1 LEU A 490 36.936 -6.772 73.731 1.00 22.16 C ATOM 1146 CD2 LEU A 490 36.170 -7.352 71.440 1.00 22.11 C ATOM 1147 N LEU A 491 31.209 -7.645 74.150 1.00 18.12 N ATOM 1148 CA LEU A 491 30.027 -8.448 74.555 1.00 16.54 C ATOM 1149 C LEU A 491 28.965 -8.574 73.480 1.00 16.29 C ATOM 1150 O LEU A 491 28.174 -9.523 73.496 1.00 15.91 O ATOM 1151 CB LEU A 491 29.362 -7.892 75.821 1.00 15.39 C ATOM 1152 CG LEU A 491 30.186 -7.935 77.102 1.00 15.36 C ATOM 1153 CD1 LEU A 491 29.334 -7.471 78.254 1.00 15.68 C ATOM 1154 CD2 LEU A 491 30.747 -9.321 77.375 1.00 15.24 C ATOM 1155 N PHE A 492 28.907 -7.656 72.528 1.00 16.94 N ATOM 1156 CA PHE A 492 27.818 -7.755 71.545 1.00 18.53 C ATOM 1157 C PHE A 492 27.981 -9.045 70.740 1.00 19.30 C ATOM 1158 O PHE A 492 29.105 -9.416 70.429 1.00 17.75 O ATOM 1159 CB PHE A 492 27.800 -6.569 70.585 1.00 17.94 C ATOM 1160 CG PHE A 492 27.216 -5.304 71.169 1.00 16.91 C ATOM 1161 CD1 PHE A 492 27.967 -4.506 72.019 1.00 16.44 C ATOM 1162 CD2 PHE A 492 25.932 -4.907 70.844 1.00 17.28 C ATOM 1163 CE1 PHE A 492 27.440 -3.335 72.532 1.00 16.84 C ATOM 1164 CE2 PHE A 492 25.401 -3.732 71.361 1.00 17.28 C ATOM 1165 CZ PHE A 492 26.155 -2.952 72.200 1.00 16.59 C ATOM 1166 N PRO A 493 26.859 -9.704 70.376 1.00 20.92 N ATOM 1167 CA PRO A 493 26.972 -10.804 69.398 1.00 23.09 C ATOM 1168 C PRO A 493 27.595 -10.292 68.107 1.00 25.38 C ATOM 1169 O PRO A 493 27.447 -9.109 67.787 1.00 23.33 O ATOM 1170 CB PRO A 493 25.523 -11.280 69.185 1.00 21.90 C ATOM 1171 CG PRO A 493 24.639 -10.341 69.918 1.00 21.05 C ATOM 1172 CD PRO A 493 25.466 -9.436 70.785 1.00 20.80 C ATOM 1173 N PRO A 494 28.356 -11.149 67.403 1.00 27.52 N ATOM 1174 CA PRO A 494 28.917 -10.756 66.112 1.00 29.30 C ATOM 1175 C PRO A 494 27.821 -10.410 65.131 1.00 24.60 C ATOM 1176 O PRO A 494 26.791 -11.082 65.106 1.00 25.43 O ATOM 1177 CB PRO A 494 29.661 -12.017 65.640 1.00 31.33 C ATOM 1178 CG PRO A 494 29.987 -12.762 66.882 1.00 34.05 C ATOM 1179 CD PRO A 494 28.967 -12.387 67.924 1.00 31.37 C ATOM 1180 N ASP A 495 28.013 -9.349 64.367 1.00 25.60 N ATOM 1181 CA ASP A 495 27.028 -8.984 63.371 1.00 25.84 C ATOM 1182 C ASP A 495 27.356 -9.713 62.082 1.00 29.18 C ATOM 1183 O ASP A 495 28.251 -9.312 61.340 1.00 29.03 O ATOM 1184 CB ASP A 495 26.953 -7.472 63.118 1.00 25.39 C ATOM 1185 CG ASP A 495 25.761 -7.094 62.225 1.00 26.22 C ATOM 1186 OD1 ASP A 495 25.509 -7.787 61.210 1.00 28.36 O ATOM 1187 OD2 ASP A 495 25.053 -6.124 62.540 1.00 21.22 O ATOM 1188 N GLU A 496 26.552 -10.732 61.800 1.00 32.22 N ATOM 1189 CA GLU A 496 26.766 -11.647 60.687 1.00 36.22 C ATOM 1190 C GLU A 496 26.697 -10.995 59.303 1.00 35.73 C ATOM 1191 O GLU A 496 26.908 -11.692 58.321 1.00 35.54 O ATOM 1192 CB GLU A 496 25.711 -12.780 60.730 1.00 39.97 C ATOM 1193 CG GLU A 496 25.551 -13.504 62.068 1.00 45.03 C ATOM 1194 CD GLU A 496 26.826 -14.185 62.556 1.00 46.89 C ATOM 1195 OE1 GLU A 496 27.770 -14.398 61.757 1.00 51.21 O ATOM 1196 OE2 GLU A 496 26.874 -14.514 63.757 1.00 50.96 O ATOM 1197 N SER A 497 26.375 -9.691 59.222 1.00 31.95 N ATOM 1198 CA SER A 497 26.162 -9.000 57.932 1.00 32.67 C ATOM 1199 C SER A 497 27.017 -7.751 57.689 1.00 32.96 C ATOM 1200 O SER A 497 26.835 -7.068 56.669 1.00 33.92 O ATOM 1201 CB SER A 497 24.686 -8.594 57.801 1.00 35.67 C ATOM 1202 OG SER A 497 24.366 -7.504 58.652 1.00 40.00 O ATOM 1203 N ILE A 498 27.920 -7.417 58.611 1.00 29.69 N ATOM 1204 CA ILE A 498 28.818 -6.283 58.385 1.00 27.78 C ATOM 1205 C ILE A 498 30.253 -6.759 58.155 1.00 27.86 C ATOM 1206 O ILE A 498 30.817 -7.489 58.958 1.00 26.98 O ATOM 1207 CB ILE A 498 28.809 -5.268 59.551 1.00 25.70 C ATOM 1208 CG1 ILE A 498 27.406 -4.651 59.741 1.00 23.43 C ATOM 1209 CG2 ILE A 498 29.827 -4.165 59.270 1.00 27.23 C ATOM 1210 CD1 ILE A 498 27.251 -3.887 61.047 1.00 21.68 C ATOM 1211 N ASP A 499 30.835 -6.304 57.065 1.00 27.01 N ATOM 1212 CA ASP A 499 32.180 -6.662 56.697 1.00 31.84 C ATOM 1213 C ASP A 499 33.052 -5.486 57.096 1.00 32.29 C ATOM 1214 O ASP A 499 32.909 -4.381 56.575 1.00 31.29 O ATOM 1215 CB ASP A 499 32.224 -6.907 55.184 1.00 35.30 C ATOM 1216 CG ASP A 499 33.552 -7.470 54.707 1.00 38.34 C ATOM 1217 OD1 ASP A 499 34.614 -6.950 55.095 1.00 35.18 O ATOM 1218 OD2 ASP A 499 33.526 -8.428 53.915 1.00 45.12 O ATOM 1219 N LEU A 500 33.980 -5.718 58.002 1.00 33.39 N ATOM 1220 CA LEU A 500 34.749 -4.609 58.561 1.00 39.38 C ATOM 1221 C LEU A 500 35.785 -4.018 57.587 1.00 38.84 C ATOM 1222 O LEU A 500 36.520 -3.096 57.965 1.00 39.12 O ATOM 1223 CB LEU A 500 35.397 -5.057 59.879 1.00 39.28 C ATOM 1224 CG LEU A 500 34.347 -5.500 60.918 1.00 42.02 C ATOM 1225 CD1 LEU A 500 34.974 -6.142 62.156 1.00 43.36 C ATOM 1226 CD2 LEU A 500 33.450 -4.325 61.301 1.00 40.49 C ATOM 1227 N TYR A 501 35.807 -4.524 56.335 1.00 38.87 N ATOM 1228 CA TYR A 501 36.741 -4.074 55.285 1.00 35.07 C ATOM 1229 C TYR A 501 36.626 -2.581 54.994 1.00 35.97 C ATOM 1230 O TYR A 501 37.643 -1.885 54.948 1.00 35.70 O ATOM 1231 CB TYR A 501 36.549 -4.875 53.958 1.00 34.72 C ATOM 1232 CG ATYR A 501 35.464 -4.317 53.038 0.50 32.77 C ATOM 1233 CD1ATYR A 501 34.112 -4.487 53.327 0.50 32.06 C ATOM 1234 CD2ATYR A 501 35.796 -3.591 51.906 0.50 33.17 C ATOM 1235 CE1ATYR A 501 33.134 -3.961 52.514 0.50 30.88 C ATOM 1236 CE2ATYR A 501 34.817 -3.065 51.085 0.50 32.04 C ATOM 1237 CZ ATYR A 501 33.491 -3.254 51.395 0.50 31.66 C ATOM 1238 OH ATYR A 501 32.520 -2.736 50.569 0.50 30.98 O ATOM 1239 N GLN A 502 35.398 -2.086 54.801 1.00 38.61 N ATOM 1240 CA GLN A 502 35.185 -0.686 54.385 1.00 44.03 C ATOM 1241 C GLN A 502 35.452 0.236 55.559 1.00 44.96 C ATOM 1242 O GLN A 502 36.043 1.316 55.398 1.00 47.79 O ATOM 1243 CB GLN A 502 33.752 -0.459 53.868 1.00 43.51 C ATOM 1244 N VAL A 503 35.024 -0.214 56.742 1.00 51.27 N ATOM 1245 CA VAL A 503 35.202 0.543 57.985 1.00 49.31 C ATOM 1246 C VAL A 503 36.684 0.749 58.207 1.00 47.25 C ATOM 1247 O VAL A 503 37.135 1.880 58.397 1.00 48.43 O ATOM 1248 CB VAL A 503 34.595 -0.184 59.214 1.00 52.30 C ATOM 1249 CG1 VAL A 503 34.708 0.690 60.456 1.00 53.95 C ATOM 1250 CG2 VAL A 503 33.137 -0.567 58.966 1.00 54.99 C ATOM 1251 N ILE A 504 37.443 -0.351 58.162 1.00 45.90 N ATOM 1252 CA ILE A 504 38.906 -0.279 58.271 1.00 42.28 C ATOM 1253 C ILE A 504 39.498 0.503 57.085 1.00 40.68 C ATOM 1254 O ILE A 504 40.438 1.271 57.271 1.00 48.36 O ATOM 1255 CB ILE A 504 39.559 -1.676 58.417 1.00 38.13 C ATOM 1256 CG1 ILE A 504 39.103 -2.327 59.723 1.00 36.65 C ATOM 1257 CG2 ILE A 504 41.092 -1.570 58.422 1.00 37.20 C ATOM 1258 CD1 ILE A 504 39.574 -3.752 59.912 1.00 34.69 C ATOM 1259 N HIS A 505 38.940 0.329 55.888 1.00 42.65 N ATOM 1260 CA HIS A 505 39.393 1.089 54.708 1.00 48.41 C ATOM 1261 C HIS A 505 39.411 2.591 54.993 1.00 50.43 C ATOM 1262 O HIS A 505 40.433 3.249 54.807 1.00 55.29 O ATOM 1263 CB HIS A 505 38.517 0.798 53.481 1.00 47.12 C ATOM 1264 N LYS A 506 38.283 3.112 55.470 1.00 57.63 N ATOM 1265 CA LYS A 506 38.147 4.542 55.806 1.00 60.98 C ATOM 1266 C LYS A 506 39.236 5.065 56.747 1.00 64.96 C ATOM 1267 O LYS A 506 39.763 6.164 56.554 1.00 73.53 O ATOM 1268 CB LYS A 506 36.782 4.805 56.424 1.00 57.54 C ATOM 1269 CG LYS A 506 35.646 4.698 55.428 1.00 58.16 C ATOM 1270 CD LYS A 506 34.400 4.130 56.078 1.00 58.07 C ATOM 1271 CE LYS A 506 33.157 4.422 55.259 1.00 56.91 C ATOM 1272 NZ LYS A 506 32.669 5.803 55.514 1.00 55.66 N ATOM 1273 N MET A 507 39.576 4.276 57.756 1.00 62.31 N ATOM 1274 CA MET A 507 40.619 4.659 58.695 1.00 59.25 C ATOM 1275 C MET A 507 41.983 4.460 58.034 1.00 60.68 C ATOM 1276 O MET A 507 42.651 5.421 57.654 1.00 62.54 O ATOM 1277 CB MET A 507 40.534 3.810 59.964 1.00 55.56 C ATOM 1278 CG MET A 507 39.165 3.770 60.625 1.00 50.52 C ATOM 1279 SD MET A 507 38.828 2.148 61.329 1.00 49.82 S ATOM 1280 CE MET A 507 40.302 1.911 62.320 1.00 46.31 C TER 1281 MET A 507 ATOM 1282 O5' G B 1 21.443 23.114 79.489 1.00 28.65 O ATOM 1283 C5' G B 1 20.253 22.525 78.891 1.00 29.69 C ATOM 1284 C4' G B 1 20.070 21.073 79.308 1.00 25.90 C ATOM 1285 O4' G B 1 21.266 20.315 78.932 1.00 22.45 O ATOM 1286 C3' G B 1 19.860 20.806 80.810 1.00 24.30 C ATOM 1287 O3' G B 1 18.953 19.735 81.160 1.00 23.55 O ATOM 1288 C2' G B 1 21.253 20.373 81.257 1.00 23.67 C ATOM 1289 O2' G B 1 21.273 19.660 82.481 1.00 22.51 O ATOM 1290 C1' G B 1 21.684 19.550 80.043 1.00 22.42 C ATOM 1291 N9 G B 1 23.119 19.302 79.941 1.00 23.60 N ATOM 1292 C8 G B 1 24.142 20.184 80.211 1.00 24.12 C ATOM 1293 N7 G B 1 25.325 19.655 80.059 1.00 23.20 N ATOM 1294 C5 G B 1 25.071 18.345 79.674 1.00 23.40 C ATOM 1295 C6 G B 1 25.966 17.292 79.354 1.00 25.08 C ATOM 1296 O6 G B 1 27.203 17.297 79.383 1.00 22.96 O ATOM 1297 N1 G B 1 25.284 16.135 78.979 1.00 24.54 N ATOM 1298 C2 G B 1 23.915 16.002 78.942 1.00 23.68 C ATOM 1299 N2 G B 1 23.442 14.797 78.571 1.00 21.84 N ATOM 1300 N3 G B 1 23.072 16.979 79.235 1.00 20.77 N ATOM 1301 C4 G B 1 23.714 18.118 79.575 1.00 22.92 C ATOM 1302 P G B 2 17.395 20.036 81.369 1.00 21.80 P ATOM 1303 OP1 G B 2 17.304 21.368 82.033 1.00 23.13 O ATOM 1304 OP2 G B 2 16.781 18.855 81.982 1.00 23.26 O ATOM 1305 O5' G B 2 16.872 20.186 79.870 1.00 17.63 O ATOM 1306 C5' G B 2 16.805 19.037 79.031 1.00 16.58 C ATOM 1307 C4' G B 2 16.046 19.346 77.778 1.00 15.30 C ATOM 1308 O4' G B 2 16.562 20.564 77.177 1.00 14.89 O ATOM 1309 C3' G B 2 16.163 18.288 76.692 1.00 15.35 C ATOM 1310 O3' G B 2 15.156 17.286 76.857 1.00 15.08 O ATOM 1311 C2' G B 2 15.903 19.086 75.416 1.00 15.30 C ATOM 1312 O2' G B 2 14.518 19.201 75.182 1.00 16.34 O ATOM 1313 C1' G B 2 16.472 20.466 75.754 1.00 15.52 C ATOM 1314 N9 G B 2 17.792 20.731 75.179 1.00 16.43 N ATOM 1315 C8 G B 2 18.099 21.690 74.242 1.00 15.64 C ATOM 1316 N7 G B 2 19.366 21.715 73.929 1.00 16.70 N ATOM 1317 C5 G B 2 19.932 20.706 74.702 1.00 17.57 C ATOM 1318 C6 G B 2 21.280 20.265 74.796 1.00 17.47 C ATOM 1319 O6 G B 2 22.268 20.676 74.183 1.00 17.65 O ATOM 1320 N1 G B 2 21.413 19.212 75.699 1.00 15.73 N ATOM 1321 C2 G B 2 20.388 18.669 76.433 1.00 15.96 C ATOM 1322 N2 G B 2 20.721 17.679 77.281 1.00 15.04 N ATOM 1323 N3 G B 2 19.130 19.077 76.362 1.00 14.94 N ATOM 1324 C4 G B 2 18.977 20.094 75.485 1.00 15.97 C HETATM 1325 C2 6MZ B 3 15.467 10.815 70.006 1.00 11.32 C HETATM 1326 C4 6MZ B 3 17.121 11.611 71.464 1.00 11.00 C HETATM 1327 C5 6MZ B 3 18.010 11.890 70.368 1.00 11.05 C HETATM 1328 O1P 6MZ B 3 14.289 14.950 77.327 1.00 15.42 O HETATM 1329 O2P 6MZ B 3 16.236 15.932 78.697 1.00 15.60 O HETATM 1330 N9 6MZ B 3 17.775 11.927 72.564 1.00 12.04 N HETATM 1331 N3 6MZ B 3 15.873 11.080 71.255 1.00 10.51 N HETATM 1332 N1 6MZ B 3 16.247 11.071 68.953 1.00 12.21 N HETATM 1333 C6 6MZ B 3 17.481 11.599 69.038 1.00 11.44 C HETATM 1334 N6 6MZ B 3 18.218 11.849 67.933 1.00 13.26 N HETATM 1335 C9 6MZ B 3 17.767 11.564 66.601 1.00 13.13 C HETATM 1336 N7 6MZ B 3 19.160 12.400 70.885 1.00 11.60 N HETATM 1337 C8 6MZ B 3 18.988 12.427 72.232 1.00 12.45 C HETATM 1338 O5' 6MZ B 3 16.579 15.417 76.260 1.00 13.38 O HETATM 1339 C5' 6MZ B 3 17.612 14.403 76.423 1.00 12.35 C HETATM 1340 C4' 6MZ B 3 17.124 13.060 75.846 1.00 11.68 C HETATM 1341 O4' 6MZ B 3 16.994 13.146 74.400 1.00 11.85 O HETATM 1342 C1' 6MZ B 3 17.176 11.820 73.896 1.00 11.55 C HETATM 1343 C2' 6MZ B 3 17.933 10.993 74.913 1.00 11.32 C HETATM 1344 O2' 6MZ B 3 17.123 9.823 75.147 1.00 11.99 O HETATM 1345 C3' 6MZ B 3 18.085 11.901 76.088 1.00 12.09 C HETATM 1346 O3' 6MZ B 3 17.809 11.253 77.325 1.00 13.13 O HETATM 1347 P 6MZ B 3 15.499 15.811 77.405 1.00 15.59 P ATOM 1348 P C B 4 18.779 11.204 78.585 1.00 14.43 P ATOM 1349 OP1 C B 4 17.998 11.583 79.776 1.00 14.76 O ATOM 1350 OP2 C B 4 20.130 11.806 78.344 1.00 13.09 O ATOM 1351 O5' C B 4 19.112 9.650 78.695 1.00 15.24 O ATOM 1352 C5' C B 4 18.329 8.785 79.550 1.00 14.14 C ATOM 1353 C4' C B 4 19.230 8.048 80.504 1.00 12.89 C ATOM 1354 O4' C B 4 19.757 8.958 81.489 1.00 13.66 O ATOM 1355 C3' C B 4 18.567 6.967 81.347 1.00 13.44 C ATOM 1356 O3' C B 4 18.474 5.783 80.559 1.00 11.88 O ATOM 1357 C2' C B 4 19.543 6.814 82.512 1.00 13.79 C ATOM 1358 O2' C B 4 20.547 5.847 82.316 1.00 13.50 O ATOM 1359 C1' C B 4 20.158 8.216 82.631 1.00 13.64 C ATOM 1360 N1 C B 4 19.697 8.923 83.826 1.00 15.65 N ATOM 1361 C2 C B 4 20.496 8.930 84.978 1.00 18.98 C ATOM 1362 O2 C B 4 21.601 8.365 84.949 1.00 20.34 O ATOM 1363 N3 C B 4 20.072 9.607 86.071 1.00 22.00 N ATOM 1364 C4 C B 4 18.880 10.207 86.061 1.00 20.72 C ATOM 1365 N4 C B 4 18.493 10.842 87.167 1.00 24.49 N ATOM 1366 C5 C B 4 18.040 10.198 84.911 1.00 19.87 C ATOM 1367 C6 C B 4 18.478 9.542 83.829 1.00 17.64 C ATOM 1368 P U B 5 17.308 4.670 80.779 1.00 12.34 P ATOM 1369 OP1 U B 5 17.342 3.802 79.583 1.00 10.43 O ATOM 1370 OP2 U B 5 16.053 5.335 81.246 1.00 11.70 O ATOM 1371 O5' U B 5 17.768 3.813 82.030 1.00 11.92 O ATOM 1372 C5' U B 5 18.969 3.002 81.971 1.00 12.90 C ATOM 1373 C4' U B 5 19.338 2.541 83.349 1.00 13.28 C ATOM 1374 O4' U B 5 19.691 3.695 84.124 1.00 13.36 O ATOM 1375 C3' U B 5 18.221 1.853 84.115 1.00 13.87 C ATOM 1376 O3' U B 5 18.296 0.460 83.807 1.00 17.55 O ATOM 1377 C2' U B 5 18.529 2.194 85.577 1.00 14.34 C ATOM 1378 O2' U B 5 19.353 1.227 86.186 1.00 13.45 O ATOM 1379 C1' U B 5 19.267 3.534 85.466 1.00 14.79 C ATOM 1380 N1 U B 5 18.489 4.730 85.840 1.00 17.17 N ATOM 1381 C2 U B 5 18.969 5.525 86.872 1.00 19.09 C ATOM 1382 O2 U B 5 19.989 5.272 87.487 1.00 22.50 O ATOM 1383 N3 U B 5 18.210 6.633 87.143 1.00 18.92 N ATOM 1384 C4 U B 5 17.056 7.030 86.507 1.00 20.19 C ATOM 1385 O4 U B 5 16.492 8.061 86.868 1.00 19.15 O ATOM 1386 C5 U B 5 16.627 6.161 85.451 1.00 18.26 C ATOM 1387 C6 U B 5 17.339 5.066 85.165 1.00 17.22 C TER 1388 U B 5 HETATM 1389 UNK UNX A 601 36.656 0.201 83.446 1.00 22.47 X HETATM 1390 UNK UNX A 602 17.301 -0.856 66.911 1.00 20.41 X HETATM 1391 UNK UNX A 603 22.331 19.161 66.596 1.00 15.35 X HETATM 1392 UNK UNX A 604 22.037 6.188 89.535 1.00 19.08 X HETATM 1393 UNK UNX A 605 11.572 -0.554 74.540 1.00 26.74 X HETATM 1394 UNK UNX A 606 25.956 -14.629 78.209 1.00 17.36 X HETATM 1395 UNK UNX A 607 21.583 4.536 79.746 1.00 8.32 X HETATM 1396 O HOH A 701 22.149 11.357 70.868 1.00 13.91 O HETATM 1397 O HOH A 702 23.782 16.584 66.086 1.00 19.55 O HETATM 1398 O HOH A 703 21.546 15.079 75.144 1.00 20.36 O HETATM 1399 O HOH A 704 36.283 6.884 75.643 1.00 14.82 O HETATM 1400 O HOH A 705 38.682 5.516 75.347 1.00 16.92 O HETATM 1401 O HOH A 706 34.027 11.558 84.135 1.00 15.74 O HETATM 1402 O HOH A 707 33.903 -8.282 77.026 1.00 12.15 O HETATM 1403 O HOH A 708 31.187 -7.881 69.653 1.00 19.67 O HETATM 1404 O HOH A 709 15.275 -2.744 71.121 1.00 20.53 O HETATM 1405 O HOH A 710 20.147 -8.925 67.340 1.00 28.70 O HETATM 1406 O HOH A 711 26.831 1.614 58.142 1.00 22.21 O HETATM 1407 O HOH A 712 16.218 19.313 51.170 1.00 15.20 O HETATM 1408 O HOH A 713 23.481 -4.015 83.458 1.00 18.68 O HETATM 1409 O HOH A 714 25.608 -2.376 82.752 1.00 17.71 O HETATM 1410 O HOH A 715 26.740 -9.490 83.535 1.00 17.71 O HETATM 1411 O HOH A 716 40.250 8.270 84.267 1.00 16.72 O HETATM 1412 O HOH A 717 35.635 8.219 64.224 1.00 12.42 O HETATM 1413 O HOH A 718 40.209 2.738 66.002 1.00 22.97 O HETATM 1414 O HOH A 719 27.267 14.828 57.748 1.00 33.38 O HETATM 1415 O HOH A 720 25.534 10.284 82.613 1.00 15.00 O HETATM 1416 O HOH A 721 19.711 -2.075 88.228 1.00 20.33 O HETATM 1417 O HOH A 722 41.144 -3.025 70.917 1.00 20.03 O HETATM 1418 O HOH A 723 16.577 1.042 79.757 0.50 2.11 O HETATM 1419 O HOH A 724 12.905 22.115 75.312 1.00 27.65 O HETATM 1420 O AHOH A 725 27.896 4.673 81.355 0.50 3.11 O HETATM 1421 O BHOH A 725 27.822 4.340 84.248 0.50 5.17 O HETATM 1422 O HOH A 726 23.404 2.355 57.839 1.00 21.00 O HETATM 1423 O HOH A 727 29.822 20.433 74.800 1.00 23.75 O HETATM 1424 O HOH A 728 33.433 9.132 87.862 1.00 18.62 O HETATM 1425 O HOH A 729 31.330 12.312 79.490 1.00 21.38 O HETATM 1426 O HOH A 730 34.093 -2.704 85.118 1.00 28.10 O HETATM 1427 O HOH A 731 31.112 -8.159 61.433 1.00 35.89 O HETATM 1428 O HOH A 732 28.144 2.297 55.953 1.00 28.99 O HETATM 1429 O HOH A 733 14.112 25.300 68.357 1.00 38.62 O HETATM 1430 O HOH A 734 15.089 23.854 75.249 1.00 25.12 O HETATM 1431 O HOH A 735 22.678 -9.654 84.719 1.00 30.33 O HETATM 1432 O HOH A 736 19.020 -3.831 84.353 1.00 16.25 O HETATM 1433 O HOH A 737 21.712 22.010 66.314 1.00 28.84 O HETATM 1434 O HOH A 738 18.457 16.585 61.008 1.00 25.87 O HETATM 1435 O HOH A 739 37.898 9.889 64.354 1.00 15.34 O HETATM 1436 O HOH A 740 28.756 11.711 84.415 1.00 22.63 O HETATM 1437 O HOH A 741 9.714 10.480 70.921 1.00 20.08 O HETATM 1438 O HOH A 742 9.432 -1.930 72.393 1.00 29.29 O HETATM 1439 O HOH A 743 16.719 0.013 60.563 1.00 24.39 O HETATM 1440 O HOH A 744 13.142 3.508 60.191 1.00 35.31 O HETATM 1441 O HOH A 745 25.286 5.352 54.882 1.00 31.70 O HETATM 1442 O HOH A 746 35.391 15.627 73.481 1.00 22.27 O HETATM 1443 O HOH A 747 32.796 -3.824 87.753 1.00 25.91 O HETATM 1444 O HOH A 748 37.723 16.276 73.506 1.00 24.10 O HETATM 1445 O HOH A 749 7.152 16.674 69.184 1.00 27.34 O HETATM 1446 O HOH A 750 29.487 21.160 62.827 1.00 32.04 O HETATM 1447 O HOH A 751 22.502 19.235 57.835 1.00 25.73 O HETATM 1448 O HOH A 752 21.863 16.953 53.196 1.00 24.24 O HETATM 1449 O HOH A 753 18.965 -4.260 63.804 1.00 25.67 O HETATM 1450 O HOH A 754 23.937 -5.161 60.113 1.00 30.88 O HETATM 1451 O HOH A 755 37.247 7.092 88.110 1.00 24.48 O HETATM 1452 O HOH A 756 25.886 9.855 87.617 1.00 24.62 O HETATM 1453 O HOH A 757 44.902 4.555 72.657 1.00 30.81 O HETATM 1454 O HOH A 758 38.219 9.774 61.606 1.00 29.45 O HETATM 1455 O HOH A 759 19.962 18.894 58.718 1.00 23.48 O HETATM 1456 O HOH A 760 16.713 18.550 62.088 1.00 30.28 O HETATM 1457 O HOH A 761 20.132 23.168 63.508 1.00 35.10 O HETATM 1458 O HOH A 762 14.846 11.263 56.749 1.00 25.79 O HETATM 1459 O HOH A 763 29.049 -6.039 54.597 1.00 32.82 O HETATM 1460 O HOH A 764 29.691 6.688 56.592 1.00 30.41 O HETATM 1461 O HOH A 765 26.741 7.427 56.400 1.00 34.15 O HETATM 1462 O HOH A 766 29.067 21.526 67.194 1.00 31.65 O HETATM 1463 O HOH A 767 12.679 6.178 83.434 1.00 23.74 O HETATM 1464 O HOH A 768 39.736 7.549 86.855 1.00 23.86 O HETATM 1465 O HOH A 769 41.999 6.965 82.720 1.00 33.85 O HETATM 1466 O HOH A 770 36.596 -8.376 77.372 0.50 17.21 O HETATM 1467 O HOH A 771 34.015 -11.063 73.407 1.00 29.86 O HETATM 1468 O HOH A 772 11.489 2.273 75.373 1.00 33.40 O HETATM 1469 O HOH A 773 9.938 10.536 73.396 1.00 25.33 O HETATM 1470 O HOH A 774 43.729 14.245 65.040 1.00 30.49 O HETATM 1471 O HOH B 101 20.707 14.329 77.685 1.00 9.60 O HETATM 1472 O HOH B 102 18.951 16.156 79.014 1.00 15.39 O HETATM 1473 O AHOH B 103 15.337 11.582 80.600 0.50 6.69 O HETATM 1474 O BHOH B 103 15.812 9.898 82.150 0.50 8.32 O HETATM 1475 O HOH B 104 14.492 7.240 81.679 1.00 20.88 O HETATM 1476 O HOH B 105 17.120 23.572 80.777 1.00 13.62 O HETATM 1477 O HOH B 106 15.584 11.863 86.686 1.00 29.35 O HETATM 1478 O HOH B 107 17.022 23.206 78.127 1.00 20.20 O HETATM 1479 O HOH B 108 23.475 17.107 75.411 0.50 7.83 O HETATM 1480 O HOH B 109 24.248 8.748 85.274 1.00 19.95 O HETATM 1481 O HOH B 110 19.569 23.889 72.200 1.00 27.14 O HETATM 1482 O HOH B 111 10.765 12.636 78.637 1.00 18.08 O HETATM 1483 O HOH B 112 13.751 12.278 78.409 1.00 25.94 O HETATM 1484 O HOH B 113 15.569 16.456 81.579 1.00 30.88 O HETATM 1485 O HOH B 114 26.522 13.567 78.627 1.00 19.16 O HETATM 1486 O HOH B 115 27.322 21.409 79.830 1.00 25.16 O CONECT 1310 1347 CONECT 1325 1331 1332 CONECT 1326 1327 1330 1331 CONECT 1327 1326 1333 1336 CONECT 1328 1347 CONECT 1329 1347 CONECT 1330 1326 1337 1342 CONECT 1331 1325 1326 CONECT 1332 1325 1333 CONECT 1333 1327 1332 1334 CONECT 1334 1333 1335 CONECT 1335 1334 CONECT 1336 1327 1337 CONECT 1337 1330 1336 CONECT 1338 1339 1347 CONECT 1339 1338 1340 CONECT 1340 1339 1341 1345 CONECT 1341 1340 1342 CONECT 1342 1330 1341 1343 CONECT 1343 1342 1344 1345 CONECT 1344 1343 CONECT 1345 1340 1343 1346 CONECT 1346 1345 1348 CONECT 1347 1310 1328 1329 1338 CONECT 1348 1346 MASTER 277 0 8 8 8 0 0 6 1477 2 25 14 END
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Complexes with the same small molecule ligand
PDB Code
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Ligand Name
No complexes with the same small molecule ligand are found!
Entry Information
PDB ID
4r3i
Complex Type
Protein-Nucleic Acid
PDBbind Subset
general set
Protein Name
YTH domain-containing protein 1, YTHDC1 YTH domain
Ligand Name
GG(m6A)CU RNA
EC.Number
E.C.-.-.-.-
Resolution
1.8(Å)
Affinity (Kd/Ki/IC50)
Kd=2uM
Release Year
2014
Protein/NA Sequence
Check fasta file
Primary Reference
(2014) Nat.Chem.Biol. Vol. 10: pp. 927-929
Links to External Databases
RCSB PDB
The mother database
PDBsum
Enhanced annotations on PDB entries
Pubchem
Comprehensive collection of chemical and biological data
UniProtKB AC
UniProt accession number (AC):
Q96MU7
Entrez Gene ID
NCBI Entrez Gene ID:
91746
ASD
Information of known allosteric effects of PDB entries
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