Browse entries in the PDBbind-CN Database
HEADER RNA BINDING PROTEIN/METAL BINDING PROTEI30-JAN-15 4XXB TITLE CRYSTAL STRUCTURE OF HUMAN MDM2-RPL11 COMPND MOL_ID: 1; COMPND 2 MOLECULE: 60S RIBOSOMAL PROTEIN L11; COMPND 3 CHAIN: A; COMPND 4 SYNONYM: CLL-ASSOCIATED ANTIGEN KW-12; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: E3 UBIQUITIN-PROTEIN LIGASE MDM2; COMPND 8 CHAIN: B; COMPND 9 FRAGMENT: UNP RESIDUES 293-334; COMPND 10 SYNONYM: DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53-BINDING COMPND 11 PROTEIN MDM2; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: RPL11; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_COMMON: HUMAN; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 GENE: MDM2; SOURCE 13 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 562 KEYWDS MDM2, RPL11, MODPIPE MODEL OF UP, RNA BINDING PROTEIN-METAL BINDING KEYWDS 2 PROTEIN COMPLEX EXPDTA X-RAY DIFFRACTION AUTHOR J.ZHENG,Z.CHEN REVDAT 2 05-FEB-20 4XXB 1 JRNL REMARK REVDAT 1 12-AUG-15 4XXB 0 JRNL AUTH J.ZHENG,Y.LANG,Q.ZHANG,D.CUI,H.SUN,L.JIANG,Z.CHEN,R.ZHANG, JRNL AUTH 2 Y.GAO,W.TIAN,W.WU,J.TANG,Z.CHEN JRNL TITL STRUCTURE OF HUMAN MDM2 COMPLEXED WITH RPL11 REVEALS THE JRNL TITL 2 MOLECULAR BASIS OF P53 ACTIVATION JRNL REF GENES DEV. V. 29 1524 2015 JRNL REFN ISSN 0890-9369 JRNL PMID 26220995 JRNL DOI 10.1101/GAD.261792.115 REMARK 2 REMARK 2 RESOLUTION. 2.40 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.6.0117 REMARK 3 AUTHORS : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER, REMARK 3 : NICHOLLS,WINN,LONG,VAGIN REMARK 3 REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.40 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 50.00 REMARK 3 DATA CUTOFF (SIGMA(F)) : NULL REMARK 3 COMPLETENESS FOR RANGE (%) : 99.0 REMARK 3 NUMBER OF REFLECTIONS : 8807 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3 R VALUE (WORKING + TEST SET) : 0.194 REMARK 3 R VALUE (WORKING SET) : 0.192 REMARK 3 FREE R VALUE : 0.227 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 4.800 REMARK 3 FREE R VALUE TEST SET COUNT : 447 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 2.40 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 2.46 REMARK 3 REFLECTION IN BIN (WORKING SET) : 517 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 90.30 REMARK 3 BIN R VALUE (WORKING SET) : 0.3090 REMARK 3 BIN FREE R VALUE SET COUNT : 32 REMARK 3 BIN FREE R VALUE : 0.3420 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 1533 REMARK 3 NUCLEIC ACID ATOMS : 0 REMARK 3 HETEROGEN ATOMS : 11 REMARK 3 SOLVENT ATOMS : 84 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 53.02 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : 2.24000 REMARK 3 B22 (A**2) : 2.24000 REMARK 3 B33 (A**2) : -3.36000 REMARK 3 B12 (A**2) : 1.12000 REMARK 3 B13 (A**2) : 0.00000 REMARK 3 B23 (A**2) : 0.00000 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A): 0.396 REMARK 3 ESU BASED ON FREE R VALUE (A): 0.238 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): 0.183 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 8.084 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.959 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.941 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A): 1572 ; 0.007 ; 0.019 REMARK 3 BOND LENGTHS OTHERS (A): NULL ; NULL ; NULL REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 2115 ; 1.173 ; 1.967 REMARK 3 BOND ANGLES OTHERS (DEGREES): NULL ; NULL ; NULL REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 190 ; 5.743 ; 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 74 ;36.353 ;23.108 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 276 ;18.358 ;15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 15 ;16.149 ;15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 224 ; 0.086 ; 0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A): 1195 ; 0.003 ; 0.021 REMARK 3 GENERAL PLANES OTHERS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED CONTACTS OTHERS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) OTHERS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 LONG RANGE B REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 LONG RANGE B OTHER ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : MASK REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN USED IF PRESENT IN REMARK 3 THE INPUT REMARK 4 REMARK 4 4XXB COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 04-FEB-15. REMARK 100 THE DEPOSITION ID IS D_1000206458. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 18-NOV-12 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : 8.0 REMARK 200 NUMBER OF CRYSTALS USED : NULL REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : PHOTON FACTORY REMARK 200 BEAMLINE : AR-NE3A REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 1 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : CCD REMARK 200 DETECTOR MANUFACTURER : ADSC QUANTUM 270 REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000 REMARK 200 DATA SCALING SOFTWARE : HKL-3000 REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 9288 REMARK 200 RESOLUTION RANGE HIGH (A) : 2.400 REMARK 200 RESOLUTION RANGE LOW (A) : 50.000 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 99.0 REMARK 200 DATA REDUNDANCY : 15.40 REMARK 200 R MERGE (I) : NULL REMARK 200 R SYM (I) : NULL REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : 37.5000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.40 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.44 REMARK 200 COMPLETENESS FOR SHELL (%) : NULL REMARK 200 DATA REDUNDANCY IN SHELL : 5.20 REMARK 200 R MERGE FOR SHELL (I) : 0.57000 REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 <I/SIGMA(I)> FOR SHELL : 2.000 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: BALBES REMARK 200 STARTING MODEL: 4V88 REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 19.14 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.52 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: PEG, PH 8.0, VAPOR DIFFUSION, HANGING REMARK 280 DROP, TEMPERATURE 293K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 32 2 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -Y,X-Y,Z+2/3 REMARK 290 3555 -X+Y,-X,Z+1/3 REMARK 290 4555 Y,X,-Z REMARK 290 5555 X-Y,-Y,-Z+1/3 REMARK 290 6555 -X,-X+Y,-Z+2/3 REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -0.500000 -0.866025 0.000000 0.00000 REMARK 290 SMTRY2 2 0.866025 -0.500000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 76.75267 REMARK 290 SMTRY1 3 -0.500000 0.866025 0.000000 0.00000 REMARK 290 SMTRY2 3 -0.866025 -0.500000 0.000000 0.00000 REMARK 290 SMTRY3 3 0.000000 0.000000 1.000000 38.37633 REMARK 290 SMTRY1 4 -0.500000 0.866025 0.000000 0.00000 REMARK 290 SMTRY2 4 0.866025 0.500000 0.000000 0.00000 REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 REMARK 290 SMTRY1 5 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 5 0.000000 -1.000000 0.000000 0.00000 REMARK 290 SMTRY3 5 0.000000 0.000000 -1.000000 38.37633 REMARK 290 SMTRY1 6 -0.500000 -0.866025 0.000000 0.00000 REMARK 290 SMTRY2 6 -0.866025 0.500000 0.000000 0.00000 REMARK 290 SMTRY3 6 0.000000 0.000000 -1.000000 76.75267 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 TOTAL BURIED SURFACE AREA: 2990 ANGSTROM**2 REMARK 350 SURFACE AREA OF THE COMPLEX: 10320 ANGSTROM**2 REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -45.0 KCAL/MOL REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 ALA A 2 REMARK 465 GLN A 3 REMARK 465 ASP A 4 REMARK 465 GLN A 5 REMARK 465 GLY A 6 REMARK 465 GLU A 7 REMARK 465 LYS A 8 REMARK 465 GLU A 9 REMARK 465 ASN A 10 REMARK 465 PRO A 11 REMARK 465 MET A 12 REMARK 465 PHE A 139 REMARK 465 SER A 140 REMARK 465 ILE A 141 REMARK 465 ALA A 142 REMARK 465 ASP A 143 REMARK 465 LYS A 144 REMARK 465 LYS A 145 REMARK 465 ARG A 146 REMARK 465 ARG A 147 REMARK 465 THR A 148 REMARK 465 GLY A 149 REMARK 465 CYS A 150 REMARK 465 ILE A 151 REMARK 465 GLY A 152 REMARK 465 ALA A 153 REMARK 465 SER B 290 REMARK 465 PHE B 291 REMARK 465 GLU B 292 REMARK 465 GLY B 335 REMARK 465 LYS B 336 REMARK 465 ASP B 337 REMARK 465 LYS B 338 REMARK 465 GLY B 339 REMARK 465 GLU B 340 REMARK 465 ILE B 341 REMARK 465 SER B 342 REMARK 465 GLU B 343 REMARK 465 LYS B 344 REMARK 465 ALA B 345 REMARK 465 LYS B 346 REMARK 465 LEU B 347 REMARK 465 GLU B 348 REMARK 465 ASN B 349 REMARK 465 SER B 350 REMARK 465 THR B 351 REMARK 465 GLN B 352 REMARK 465 ALA B 353 REMARK 465 GLU B 354 REMARK 465 GLU B 355 REMARK 465 GLY B 356 REMARK 465 PHE B 357 REMARK 465 ASP B 358 REMARK 465 VAL B 359 REMARK 465 PRO B 360 REMARK 465 ASP B 361 REMARK 465 CYS B 362 REMARK 465 LYS B 363 REMARK 465 LYS B 364 REMARK 465 THR B 365 REMARK 465 ILE B 366 REMARK 465 VAL B 367 REMARK 465 ASN B 368 REMARK 465 ASP B 369 REMARK 465 SER B 370 REMARK 465 ARG B 371 REMARK 465 GLU B 372 REMARK 465 SER B 373 REMARK 465 CYS B 374 REMARK 465 VAL B 375 REMARK 465 GLU B 376 REMARK 465 GLU B 377 REMARK 465 ASN B 378 REMARK 465 ASP B 379 REMARK 465 ASP B 380 REMARK 465 LYS B 381 REMARK 465 ILE B 382 REMARK 465 THR B 383 REMARK 465 GLN B 384 REMARK 465 ALA B 385 REMARK 465 SER B 386 REMARK 465 GLN B 387 REMARK 465 SER B 388 REMARK 465 GLN B 389 REMARK 465 GLU B 390 REMARK 465 SER B 391 REMARK 465 GLU B 392 REMARK 465 ASP B 393 REMARK 465 TYR B 394 REMARK 465 SER B 395 REMARK 465 GLN B 396 REMARK 465 PRO B 397 REMARK 465 SER B 398 REMARK 465 THR B 399 REMARK 465 SER B 400 REMARK 465 SER B 401 REMARK 465 SER B 402 REMARK 465 ILE B 403 REMARK 465 ILE B 404 REMARK 465 TYR B 405 REMARK 465 SER B 406 REMARK 465 SER B 407 REMARK 465 GLN B 408 REMARK 465 GLU B 409 REMARK 465 ASP B 410 REMARK 465 VAL B 411 REMARK 465 LYS B 412 REMARK 465 GLU B 413 REMARK 465 PHE B 414 REMARK 465 GLU B 415 REMARK 465 ARG B 416 REMARK 465 GLU B 417 REMARK 465 GLU B 418 REMARK 465 THR B 419 REMARK 465 GLN B 420 REMARK 465 ASP B 421 REMARK 465 LYS B 422 REMARK 465 GLU B 423 REMARK 465 GLU B 424 REMARK 465 SER B 425 REMARK 465 VAL B 426 REMARK 465 GLU B 427 REMARK 465 SER B 428 REMARK 465 SER B 429 REMARK 465 LEU B 430 REMARK 465 PRO B 431 REMARK 465 LEU B 432 REMARK 465 ASN B 433 REMARK 465 ALA B 434 REMARK 465 ILE B 435 REMARK 465 GLU B 436 REMARK 465 PRO B 437 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ARG A 13 CG CD NE CZ NH1 NH2 REMARK 470 LYS A 118 CG CD CE NZ REMARK 470 LYS A 154 CG CD CE NZ REMARK 470 HIS A 155 CG ND1 CD2 CE1 NE2 REMARK 470 ARG A 156 CG CD NE CZ NH1 NH2 REMARK 470 GLU B 293 CG CD OE1 OE2 REMARK 470 GLU B 332 CG CD OE1 OE2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN A 65 -2.22 69.82 REMARK 500 PRO A 137 5.30 -61.93 REMARK 500 CYS B 308 -4.40 -144.14 REMARK 500 REMARK 500 REMARK: NULL REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN A 203 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS A 25 SG REMARK 620 2 HIS B 318 NE2 91.2 REMARK 620 3 IMD A 201 N3 107.4 114.4 REMARK 620 4 HOH A 322 O 109.7 118.0 113.3 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 ZN B 501 ZN REMARK 620 N RES CSSEQI ATOM REMARK 620 1 CYS B 305 SG REMARK 620 2 CYS B 308 SG 112.0 REMARK 620 3 CYS B 319 SG 106.6 97.7 REMARK 620 4 CYS B 322 SG 106.2 116.5 117.5 REMARK 620 N 1 2 3 REMARK 800 REMARK 800 SITE REMARK 800 SITE_IDENTIFIER: AC1 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for residue IMD A 201 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC2 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for residue BME A 202 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC3 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 203 REMARK 800 REMARK 800 SITE_IDENTIFIER: AC4 REMARK 800 EVIDENCE_CODE: SOFTWARE REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 501 DBREF 4XXB A 1 178 UNP P62913 RL11_HUMAN 1 178 DBREF 4XXB B 290 437 UNP Q00987 MDM2_HUMAN 290 437 SEQRES 1 A 178 MET ALA GLN ASP GLN GLY GLU LYS GLU ASN PRO MET ARG SEQRES 2 A 178 GLU LEU ARG ILE ARG LYS LEU CYS LEU ASN ILE CYS VAL SEQRES 3 A 178 GLY GLU SER GLY ASP ARG LEU THR ARG ALA ALA LYS VAL SEQRES 4 A 178 LEU GLU GLN LEU THR GLY GLN THR PRO VAL PHE SER LYS SEQRES 5 A 178 ALA ARG TYR THR VAL ARG SER PHE GLY ILE ARG ARG ASN SEQRES 6 A 178 GLU LYS ILE ALA VAL HIS CYS THR VAL ARG GLY ALA LYS SEQRES 7 A 178 ALA GLU GLU ILE LEU GLU LYS GLY LEU LYS VAL ARG GLU SEQRES 8 A 178 TYR GLU LEU ARG LYS ASN ASN PHE SER ASP THR GLY ASN SEQRES 9 A 178 PHE GLY PHE GLY ILE GLN GLU HIS ILE ASP LEU GLY ILE SEQRES 10 A 178 LYS TYR ASP PRO SER ILE GLY ILE TYR GLY LEU ASP PHE SEQRES 11 A 178 TYR VAL VAL LEU GLY ARG PRO GLY PHE SER ILE ALA ASP SEQRES 12 A 178 LYS LYS ARG ARG THR GLY CYS ILE GLY ALA LYS HIS ARG SEQRES 13 A 178 ILE SER LYS GLU GLU ALA MET ARG TRP PHE GLN GLN LYS SEQRES 14 A 178 TYR ASP GLY ILE ILE LEU PRO GLY LYS SEQRES 1 B 148 SER PHE GLU GLU ASP PRO GLU ILE SER LEU ALA ASP TYR SEQRES 2 B 148 TRP LYS CYS THR SER CYS ASN GLU MET ASN PRO PRO LEU SEQRES 3 B 148 PRO SER HIS CYS ASN ARG CYS TRP ALA LEU ARG GLU ASN SEQRES 4 B 148 TRP LEU PRO GLU ASP LYS GLY LYS ASP LYS GLY GLU ILE SEQRES 5 B 148 SER GLU LYS ALA LYS LEU GLU ASN SER THR GLN ALA GLU SEQRES 6 B 148 GLU GLY PHE ASP VAL PRO ASP CYS LYS LYS THR ILE VAL SEQRES 7 B 148 ASN ASP SER ARG GLU SER CYS VAL GLU GLU ASN ASP ASP SEQRES 8 B 148 LYS ILE THR GLN ALA SER GLN SER GLN GLU SER GLU ASP SEQRES 9 B 148 TYR SER GLN PRO SER THR SER SER SER ILE ILE TYR SER SEQRES 10 B 148 SER GLN GLU ASP VAL LYS GLU PHE GLU ARG GLU GLU THR SEQRES 11 B 148 GLN ASP LYS GLU GLU SER VAL GLU SER SER LEU PRO LEU SEQRES 12 B 148 ASN ALA ILE GLU PRO HET IMD A 201 5 HET BME A 202 4 HET ZN A 203 1 HET ZN B 501 1 HETNAM IMD IMIDAZOLE HETNAM BME BETA-MERCAPTOETHANOL HETNAM ZN ZINC ION FORMUL 3 IMD C3 H5 N2 1+ FORMUL 4 BME C2 H6 O S FORMUL 5 ZN 2(ZN 2+) FORMUL 7 HOH *84(H2 O) HELIX 1 AA1 GLY A 30 GLY A 45 1 16 HELIX 2 AA2 VAL A 57 GLY A 61 5 5 HELIX 3 AA3 ARG A 75 ARG A 90 1 16 HELIX 4 AA4 ASN A 97 PHE A 99 5 3 HELIX 5 AA5 GLU A 111 GLY A 116 5 6 HELIX 6 AA6 SER A 158 TYR A 170 1 13 HELIX 7 AA7 SER B 298 TYR B 302 5 5 SHEET 1 AA1 5 VAL A 49 LYS A 52 0 SHEET 2 AA1 5 LYS A 67 VAL A 74 -1 O ALA A 69 N SER A 51 SHEET 3 AA1 5 ARG A 16 CYS A 25 -1 N LEU A 22 O CYS A 72 SHEET 4 AA1 5 LEU A 128 GLY A 135 -1 O TYR A 131 N CYS A 21 SHEET 5 AA1 5 PHE A 105 ILE A 109 -1 N PHE A 105 O VAL A 132 SHEET 1 AA2 2 GLU A 93 ARG A 95 0 SHEET 2 AA2 2 ILE A 173 LEU A 175 1 O LEU A 175 N LEU A 94 SHEET 1 AA3 2 TRP B 303 LYS B 304 0 SHEET 2 AA3 2 MET B 311 ASN B 312 -1 O ASN B 312 N TRP B 303 LINK SG CYS A 25 ZN ZN A 203 1555 1555 2.42 LINK SG CYS B 305 ZN ZN B 501 1555 1555 2.40 LINK SG CYS B 308 ZN ZN B 501 1555 1555 2.52 LINK NE2 HIS B 318 ZN ZN A 203 1555 1555 2.07 LINK SG CYS B 319 ZN ZN B 501 1555 1555 2.27 LINK SG CYS B 322 ZN ZN B 501 1555 1555 2.17 LINK N3 IMD A 201 ZN ZN A 203 1555 1555 2.05 LINK ZN ZN A 203 O HOH A 322 1555 1555 2.25 CISPEP 1 LEU B 315 PRO B 316 0 11.49 SITE 1 AC1 7 CYS A 25 ILE A 68 ALA A 69 ZN A 203 SITE 2 AC1 7 PRO B 316 HIS B 318 ASN B 320 SITE 1 AC2 5 CYS A 21 TYR A 131 ASP B 294 PRO B 314 SITE 2 AC2 5 LEU B 315 SITE 1 AC3 4 CYS A 25 IMD A 201 HOH A 322 HIS B 318 SITE 1 AC4 4 CYS B 305 CYS B 308 CYS B 319 CYS B 322 CRYST1 58.307 58.307 115.129 90.00 90.00 120.00 P 32 2 1 6 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.017151 0.009902 0.000000 0.00000 SCALE2 0.000000 0.019804 0.000000 0.00000 SCALE3 0.000000 0.000000 0.008686 0.00000 ATOM 1 N ARG A 13 -6.353 12.278 2.508 1.00112.09 N ATOM 2 CA ARG A 13 -6.458 11.016 1.714 1.00109.03 C ATOM 3 C ARG A 13 -6.291 9.763 2.584 1.00109.24 C ATOM 4 O ARG A 13 -6.373 8.636 2.081 1.00114.17 O ATOM 5 CB ARG A 13 -5.431 11.016 0.571 1.00107.18 C ATOM 6 N GLU A 14 -6.065 9.964 3.884 1.00104.03 N ATOM 7 CA GLU A 14 -5.857 8.851 4.818 1.00 99.74 C ATOM 8 C GLU A 14 -6.706 8.985 6.087 1.00 94.19 C ATOM 9 O GLU A 14 -6.373 8.424 7.137 1.00 94.90 O ATOM 10 CB GLU A 14 -4.371 8.704 5.172 1.00101.93 C ATOM 11 CG GLU A 14 -3.773 9.902 5.901 1.00107.34 C ATOM 12 CD GLU A 14 -2.400 9.621 6.485 1.00110.27 C ATOM 13 OE1 GLU A 14 -1.902 8.480 6.352 1.00108.22 O ATOM 14 OE2 GLU A 14 -1.816 10.552 7.080 1.00109.96 O ATOM 15 N LEU A 15 -7.799 9.736 5.980 1.00 80.35 N ATOM 16 CA LEU A 15 -8.728 9.916 7.083 1.00 68.21 C ATOM 17 C LEU A 15 -10.121 9.631 6.548 1.00 63.37 C ATOM 18 O LEU A 15 -10.500 10.153 5.502 1.00 61.43 O ATOM 19 CB LEU A 15 -8.614 11.337 7.638 1.00 65.66 C ATOM 20 CG LEU A 15 -8.760 11.604 9.140 1.00 64.71 C ATOM 21 CD1 LEU A 15 -7.850 10.717 9.976 1.00 67.31 C ATOM 22 CD2 LEU A 15 -8.469 13.065 9.445 1.00 61.09 C ATOM 23 N ARG A 16 -10.865 8.786 7.255 1.00 60.41 N ATOM 24 CA ARG A 16 -12.148 8.273 6.769 1.00 62.15 C ATOM 25 C ARG A 16 -13.286 8.506 7.763 1.00 59.74 C ATOM 26 O ARG A 16 -13.041 8.726 8.951 1.00 60.85 O ATOM 27 CB ARG A 16 -12.040 6.768 6.450 1.00 68.40 C ATOM 28 CG ARG A 16 -11.829 5.863 7.664 1.00 74.02 C ATOM 29 CD ARG A 16 -12.048 4.377 7.369 1.00 81.42 C ATOM 30 NE ARG A 16 -13.467 4.003 7.332 1.00 85.46 N ATOM 31 CZ ARG A 16 -14.079 3.418 6.300 1.00 89.44 C ATOM 32 NH1 ARG A 16 -13.407 3.105 5.195 1.00 89.51 N ATOM 33 NH2 ARG A 16 -15.373 3.131 6.376 1.00 88.93 N ATOM 34 N ILE A 17 -14.528 8.454 7.278 1.00 54.71 N ATOM 35 CA ILE A 17 -15.687 8.463 8.166 1.00 50.62 C ATOM 36 C ILE A 17 -15.897 7.070 8.758 1.00 53.89 C ATOM 37 O ILE A 17 -16.041 6.085 8.023 1.00 54.20 O ATOM 38 CB ILE A 17 -16.974 8.902 7.454 1.00 48.01 C ATOM 39 CG1 ILE A 17 -16.822 10.317 6.891 1.00 49.44 C ATOM 40 CG2 ILE A 17 -18.162 8.823 8.407 1.00 47.05 C ATOM 41 CD1 ILE A 17 -17.948 10.726 5.964 1.00 46.20 C ATOM 42 N ARG A 18 -15.909 7.000 10.087 1.00 53.94 N ATOM 43 CA ARG A 18 -16.154 5.754 10.801 1.00 51.48 C ATOM 44 C ARG A 18 -17.658 5.540 10.970 1.00 51.18 C ATOM 45 O ARG A 18 -18.178 4.458 10.671 1.00 50.80 O ATOM 46 CB ARG A 18 -15.420 5.780 12.137 1.00 54.63 C ATOM 47 CG ARG A 18 -15.810 4.698 13.116 1.00 59.77 C ATOM 48 CD ARG A 18 -14.790 4.612 14.246 1.00 67.14 C ATOM 49 NE ARG A 18 -13.608 3.835 13.860 1.00 70.09 N ATOM 50 CZ ARG A 18 -13.579 2.504 13.775 1.00 74.16 C ATOM 51 NH1 ARG A 18 -14.669 1.784 14.045 1.00 70.04 N ATOM 52 NH2 ARG A 18 -12.456 1.889 13.412 1.00 75.52 N ATOM 53 N LYS A 19 -18.358 6.573 11.432 1.00 48.87 N ATOM 54 CA LYS A 19 -19.824 6.558 11.414 1.00 47.45 C ATOM 55 C LYS A 19 -20.434 7.954 11.463 1.00 44.87 C ATOM 56 O LYS A 19 -19.777 8.928 11.828 1.00 46.60 O ATOM 57 CB LYS A 19 -20.394 5.686 12.538 1.00 48.02 C ATOM 58 CG LYS A 19 -20.237 6.260 13.937 1.00 50.72 C ATOM 59 CD LYS A 19 -20.697 5.259 14.986 1.00 52.21 C ATOM 60 CE LYS A 19 -20.536 5.805 16.395 1.00 51.23 C ATOM 61 NZ LYS A 19 -20.977 4.786 17.380 1.00 49.25 N ATOM 62 N LEU A 20 -21.695 8.028 11.068 1.00 43.89 N ATOM 63 CA LEU A 20 -22.489 9.226 11.201 1.00 44.51 C ATOM 64 C LEU A 20 -23.687 8.887 12.062 1.00 44.76 C ATOM 65 O LEU A 20 -24.449 7.982 11.736 1.00 48.88 O ATOM 66 CB LEU A 20 -22.972 9.699 9.831 1.00 44.26 C ATOM 67 CG LEU A 20 -23.987 10.848 9.830 1.00 43.42 C ATOM 68 CD1 LEU A 20 -23.306 12.145 10.229 1.00 44.08 C ATOM 69 CD2 LEU A 20 -24.649 10.995 8.471 1.00 44.15 C ATOM 70 N CYS A 21 -23.849 9.603 13.165 1.00 45.61 N ATOM 71 CA CYS A 21 -25.026 9.427 14.006 1.00 44.63 C ATOM 72 C CYS A 21 -26.012 10.542 13.725 1.00 42.02 C ATOM 73 O CYS A 21 -25.621 11.704 13.555 1.00 35.89 O ATOM 74 CB CYS A 21 -24.653 9.417 15.487 1.00 46.34 C ATOM 75 SG CYS A 21 -23.346 8.245 15.908 1.00 54.67 S ATOM 76 N LEU A 22 -27.289 10.168 13.674 1.00 42.37 N ATOM 77 CA LEU A 22 -28.386 11.109 13.480 1.00 42.71 C ATOM 78 C LEU A 22 -29.380 10.991 14.626 1.00 43.32 C ATOM 79 O LEU A 22 -29.582 9.906 15.167 1.00 43.87 O ATOM 80 CB LEU A 22 -29.107 10.825 12.161 1.00 42.34 C ATOM 81 CG LEU A 22 -28.281 10.917 10.885 1.00 41.69 C ATOM 82 CD1 LEU A 22 -28.995 10.140 9.802 1.00 41.73 C ATOM 83 CD2 LEU A 22 -28.057 12.365 10.469 1.00 41.16 C ATOM 84 N ASN A 23 -30.006 12.112 14.981 1.00 42.07 N ATOM 85 CA ASN A 23 -30.923 12.166 16.101 1.00 39.52 C ATOM 86 C ASN A 23 -31.986 13.242 15.886 1.00 38.87 C ATOM 87 O ASN A 23 -31.669 14.377 15.495 1.00 34.80 O ATOM 88 CB ASN A 23 -30.128 12.403 17.392 1.00 40.82 C ATOM 89 CG ASN A 23 -31.006 12.774 18.575 1.00 41.87 C ATOM 90 OD1 ASN A 23 -31.403 11.914 19.361 1.00 43.15 O ATOM 91 ND2 ASN A 23 -31.296 14.062 18.716 1.00 39.87 N ATOM 92 N ILE A 24 -33.244 12.859 16.113 1.00 36.62 N ATOM 93 CA ILE A 24 -34.361 13.802 16.173 1.00 37.16 C ATOM 94 C ILE A 24 -34.982 13.779 17.571 1.00 37.95 C ATOM 95 O ILE A 24 -35.426 12.724 18.043 1.00 35.94 O ATOM 96 CB ILE A 24 -35.460 13.483 15.129 1.00 36.17 C ATOM 97 CG1 ILE A 24 -34.929 13.659 13.701 1.00 35.36 C ATOM 98 CG2 ILE A 24 -36.657 14.397 15.320 1.00 34.37 C ATOM 99 CD1 ILE A 24 -35.857 13.148 12.614 1.00 32.38 C ATOM 100 N CYS A 25 -35.013 14.944 18.220 1.00 39.97 N ATOM 101 CA CYS A 25 -35.649 15.101 19.532 1.00 42.06 C ATOM 102 C CYS A 25 -37.114 15.472 19.412 1.00 42.32 C ATOM 103 O CYS A 25 -37.464 16.343 18.621 1.00 45.94 O ATOM 104 CB CYS A 25 -34.953 16.206 20.325 1.00 44.39 C ATOM 105 SG CYS A 25 -33.278 15.791 20.823 1.00 47.44 S ATOM 106 N VAL A 26 -37.965 14.833 20.214 1.00 43.19 N ATOM 107 CA VAL A 26 -39.379 15.220 20.314 1.00 43.45 C ATOM 108 C VAL A 26 -39.746 15.633 21.748 1.00 44.24 C ATOM 109 O VAL A 26 -40.397 16.656 21.949 1.00 44.38 O ATOM 110 CB VAL A 26 -40.337 14.132 19.752 1.00 45.84 C ATOM 111 CG1 VAL A 26 -41.796 14.529 19.943 1.00 44.66 C ATOM 112 CG2 VAL A 26 -40.060 13.886 18.271 1.00 44.91 C ATOM 113 N GLY A 27 -39.307 14.865 22.743 1.00 44.85 N ATOM 114 CA GLY A 27 -39.551 15.237 24.135 1.00 45.74 C ATOM 115 C GLY A 27 -40.621 14.397 24.812 1.00 48.55 C ATOM 116 O GLY A 27 -40.664 14.315 26.037 1.00 48.45 O ATOM 117 N GLU A 28 -41.490 13.776 24.022 1.00 48.59 N ATOM 118 CA GLU A 28 -42.469 12.839 24.562 1.00 51.16 C ATOM 119 C GLU A 28 -42.848 11.776 23.542 1.00 50.57 C ATOM 120 O GLU A 28 -42.651 11.954 22.339 1.00 48.92 O ATOM 121 CB GLU A 28 -43.717 13.559 25.096 1.00 52.50 C ATOM 122 CG GLU A 28 -44.461 14.398 24.068 1.00 56.42 C ATOM 123 CD GLU A 28 -45.684 15.099 24.635 1.00 59.40 C ATOM 124 OE1 GLU A 28 -45.930 15.040 25.861 1.00 59.94 O ATOM 125 OE2 GLU A 28 -46.413 15.714 23.841 1.00 62.28 O ATOM 126 N SER A 29 -43.376 10.661 24.039 1.00 52.25 N ATOM 127 CA SER A 29 -43.827 9.584 23.179 1.00 54.53 C ATOM 128 C SER A 29 -45.197 9.909 22.602 1.00 55.58 C ATOM 129 O SER A 29 -46.003 10.598 23.238 1.00 55.60 O ATOM 130 CB SER A 29 -43.869 8.270 23.942 1.00 55.78 C ATOM 131 OG SER A 29 -43.699 7.191 23.044 1.00 60.75 O ATOM 132 N GLY A 30 -45.447 9.417 21.390 1.00 56.76 N ATOM 133 CA GLY A 30 -46.710 9.656 20.702 1.00 58.00 C ATOM 134 C GLY A 30 -46.554 9.752 19.200 1.00 59.44 C ATOM 135 O GLY A 30 -45.571 9.258 18.632 1.00 60.03 O ATOM 136 N ASP A 31 -47.534 10.396 18.569 1.00 59.08 N ATOM 137 CA ASP A 31 -47.580 10.569 17.120 1.00 60.98 C ATOM 138 C ASP A 31 -46.326 11.226 16.570 1.00 58.46 C ATOM 139 O ASP A 31 -45.685 10.692 15.664 1.00 60.36 O ATOM 140 CB ASP A 31 -48.811 11.392 16.705 1.00 62.95 C ATOM 141 CG ASP A 31 -50.111 10.588 16.751 1.00 67.31 C ATOM 142 OD1 ASP A 31 -50.062 9.345 16.906 1.00 63.63 O ATOM 143 OD2 ASP A 31 -51.191 11.210 16.628 1.00 69.82 O ATOM 144 N ARG A 32 -45.976 12.381 17.124 1.00 54.33 N ATOM 145 CA ARG A 32 -44.865 13.166 16.605 1.00 53.88 C ATOM 146 C ARG A 32 -43.529 12.409 16.703 1.00 52.86 C ATOM 147 O ARG A 32 -42.674 12.543 15.826 1.00 51.23 O ATOM 148 CB ARG A 32 -44.810 14.522 17.304 1.00 56.02 C ATOM 149 CG ARG A 32 -43.807 15.502 16.719 1.00 59.56 C ATOM 150 CD ARG A 32 -44.370 16.317 15.557 1.00 66.38 C ATOM 151 NE ARG A 32 -43.455 17.378 15.113 1.00 66.52 N ATOM 152 CZ ARG A 32 -42.544 17.978 15.884 1.00 63.79 C ATOM 153 NH1 ARG A 32 -42.411 17.651 17.166 1.00 57.98 N ATOM 154 NH2 ARG A 32 -41.767 18.921 15.372 1.00 58.51 N ATOM 155 N LEU A 33 -43.365 11.599 17.749 1.00 52.73 N ATOM 156 CA LEU A 33 -42.163 10.768 17.902 1.00 53.13 C ATOM 157 C LEU A 33 -42.116 9.681 16.825 1.00 53.93 C ATOM 158 O LEU A 33 -41.106 9.532 16.142 1.00 51.93 O ATOM 159 CB LEU A 33 -42.088 10.127 19.294 1.00 52.58 C ATOM 160 CG LEU A 33 -40.730 9.863 19.978 1.00 54.78 C ATOM 161 CD1 LEU A 33 -40.868 8.795 21.055 1.00 52.52 C ATOM 162 CD2 LEU A 33 -39.591 9.493 19.040 1.00 51.50 C ATOM 163 N THR A 34 -43.214 8.937 16.674 1.00 52.72 N ATOM 164 CA THR A 34 -43.286 7.853 15.697 1.00 54.93 C ATOM 165 C THR A 34 -43.108 8.379 14.268 1.00 52.58 C ATOM 166 O THR A 34 -42.513 7.713 13.423 1.00 51.27 O ATOM 167 CB THR A 34 -44.591 7.030 15.837 1.00 59.57 C ATOM 168 OG1 THR A 34 -45.686 7.907 16.120 1.00 67.72 O ATOM 169 CG2 THR A 34 -44.477 6.030 16.978 1.00 58.24 C ATOM 170 N ARG A 35 -43.594 9.588 14.008 1.00 50.46 N ATOM 171 CA ARG A 35 -43.353 10.217 12.714 1.00 52.79 C ATOM 172 C ARG A 35 -41.885 10.620 12.520 1.00 53.58 C ATOM 173 O ARG A 35 -41.388 10.631 11.391 1.00 54.35 O ATOM 174 CB ARG A 35 -44.314 11.379 12.464 1.00 52.55 C ATOM 175 CG ARG A 35 -45.755 10.909 12.325 1.00 55.81 C ATOM 176 CD ARG A 35 -46.649 11.947 11.676 1.00 58.48 C ATOM 177 NE ARG A 35 -46.980 13.017 12.605 1.00 64.54 N ATOM 178 CZ ARG A 35 -48.102 13.077 13.318 1.00 66.88 C ATOM 179 NH1 ARG A 35 -49.020 12.120 13.204 1.00 66.92 N ATOM 180 NH2 ARG A 35 -48.303 14.098 14.148 1.00 63.67 N ATOM 181 N ALA A 36 -41.188 10.932 13.612 1.00 49.77 N ATOM 182 CA ALA A 36 -39.764 11.238 13.523 1.00 47.12 C ATOM 183 C ALA A 36 -38.954 9.980 13.217 1.00 48.68 C ATOM 184 O ALA A 36 -37.891 10.071 12.597 1.00 49.81 O ATOM 185 CB ALA A 36 -39.272 11.892 14.794 1.00 43.09 C ATOM 186 N ALA A 37 -39.455 8.821 13.657 1.00 47.19 N ATOM 187 CA ALA A 37 -38.857 7.522 13.319 1.00 50.59 C ATOM 188 C ALA A 37 -38.936 7.277 11.816 1.00 53.71 C ATOM 189 O ALA A 37 -37.926 6.953 11.185 1.00 52.58 O ATOM 190 CB ALA A 37 -39.529 6.379 14.076 1.00 45.83 C ATOM 191 N LYS A 38 -40.135 7.445 11.254 1.00 56.00 N ATOM 192 CA LYS A 38 -40.343 7.287 9.818 1.00 57.54 C ATOM 193 C LYS A 38 -39.377 8.149 9.032 1.00 55.76 C ATOM 194 O LYS A 38 -38.660 7.644 8.161 1.00 54.27 O ATOM 195 CB LYS A 38 -41.792 7.579 9.418 1.00 63.79 C ATOM 196 CG LYS A 38 -42.543 6.328 8.990 1.00 71.74 C ATOM 197 CD LYS A 38 -44.039 6.414 9.257 1.00 77.18 C ATOM 198 CE LYS A 38 -44.684 5.038 9.130 1.00 78.99 C ATOM 199 NZ LYS A 38 -46.157 5.071 9.345 1.00 79.48 N ATOM 200 N VAL A 39 -39.333 9.440 9.367 1.00 52.34 N ATOM 201 CA VAL A 39 -38.419 10.376 8.714 1.00 48.03 C ATOM 202 C VAL A 39 -36.983 9.850 8.692 1.00 49.25 C ATOM 203 O VAL A 39 -36.312 9.927 7.664 1.00 51.56 O ATOM 204 CB VAL A 39 -38.502 11.787 9.317 1.00 46.85 C ATOM 205 CG1 VAL A 39 -37.270 12.614 8.951 1.00 46.71 C ATOM 206 CG2 VAL A 39 -39.774 12.482 8.848 1.00 45.57 C ATOM 207 N LEU A 40 -36.523 9.292 9.808 1.00 48.61 N ATOM 208 CA LEU A 40 -35.204 8.673 9.833 1.00 48.39 C ATOM 209 C LEU A 40 -35.119 7.416 8.952 1.00 50.98 C ATOM 210 O LEU A 40 -34.095 7.189 8.321 1.00 49.23 O ATOM 211 CB LEU A 40 -34.747 8.386 11.268 1.00 46.55 C ATOM 212 CG LEU A 40 -34.101 9.552 12.018 1.00 43.56 C ATOM 213 CD1 LEU A 40 -33.759 9.142 13.441 1.00 42.00 C ATOM 214 CD2 LEU A 40 -32.860 10.053 11.294 1.00 41.82 C ATOM 215 N GLU A 41 -36.190 6.623 8.899 1.00 54.75 N ATOM 216 CA GLU A 41 -36.250 5.440 8.020 1.00 60.81 C ATOM 217 C GLU A 41 -36.205 5.818 6.544 1.00 60.61 C ATOM 218 O GLU A 41 -35.440 5.240 5.780 1.00 61.35 O ATOM 219 CB GLU A 41 -37.502 4.598 8.298 1.00 64.75 C ATOM 220 CG GLU A 41 -37.355 3.595 9.435 1.00 70.19 C ATOM 221 CD GLU A 41 -38.618 2.780 9.695 1.00 73.59 C ATOM 222 OE1 GLU A 41 -39.716 3.373 9.789 1.00 74.65 O ATOM 223 OE2 GLU A 41 -38.511 1.540 9.823 1.00 71.44 O ATOM 224 N GLN A 42 -37.032 6.786 6.152 1.00 65.30 N ATOM 225 CA GLN A 42 -37.046 7.300 4.781 1.00 66.57 C ATOM 226 C GLN A 42 -35.680 7.850 4.420 1.00 65.54 C ATOM 227 O GLN A 42 -35.155 7.572 3.344 1.00 70.09 O ATOM 228 CB GLN A 42 -38.054 8.445 4.621 1.00 71.76 C ATOM 229 CG GLN A 42 -39.517 8.108 4.859 1.00 75.41 C ATOM 230 CD GLN A 42 -40.381 9.353 5.056 1.00 76.52 C ATOM 231 OE1 GLN A 42 -41.584 9.247 5.290 1.00 81.79 O ATOM 232 NE2 GLN A 42 -39.772 10.532 4.969 1.00 70.86 N ATOM 233 N LEU A 43 -35.112 8.634 5.329 1.00 62.80 N ATOM 234 CA LEU A 43 -33.847 9.308 5.086 1.00 61.23 C ATOM 235 C LEU A 43 -32.670 8.340 5.035 1.00 60.81 C ATOM 236 O LEU A 43 -31.676 8.604 4.361 1.00 64.14 O ATOM 237 CB LEU A 43 -33.612 10.372 6.163 1.00 58.40 C ATOM 238 CG LEU A 43 -32.513 11.443 6.081 1.00 58.65 C ATOM 239 CD1 LEU A 43 -31.254 10.991 6.804 1.00 57.00 C ATOM 240 CD2 LEU A 43 -32.205 11.914 4.661 1.00 56.73 C ATOM 241 N THR A 44 -32.798 7.205 5.709 1.00 58.45 N ATOM 242 CA THR A 44 -31.624 6.437 6.089 1.00 58.81 C ATOM 243 C THR A 44 -31.645 4.974 5.620 1.00 61.09 C ATOM 244 O THR A 44 -30.589 4.363 5.454 1.00 60.41 O ATOM 245 CB THR A 44 -31.400 6.572 7.621 1.00 57.38 C ATOM 246 OG1 THR A 44 -30.006 6.659 7.919 1.00 60.97 O ATOM 247 CG2 THR A 44 -32.039 5.449 8.398 1.00 52.13 C ATOM 248 N GLY A 45 -32.840 4.423 5.412 1.00 62.97 N ATOM 249 CA GLY A 45 -33.001 3.023 5.005 1.00 65.42 C ATOM 250 C GLY A 45 -32.793 2.012 6.120 1.00 69.29 C ATOM 251 O GLY A 45 -32.784 0.805 5.876 1.00 71.96 O ATOM 252 N GLN A 46 -32.613 2.507 7.343 1.00 71.89 N ATOM 253 CA GLN A 46 -32.435 1.668 8.533 1.00 74.12 C ATOM 254 C GLN A 46 -33.538 1.990 9.533 1.00 73.82 C ATOM 255 O GLN A 46 -34.215 3.019 9.414 1.00 71.44 O ATOM 256 CB GLN A 46 -31.078 1.925 9.207 1.00 76.54 C ATOM 257 CG GLN A 46 -29.964 2.421 8.294 1.00 79.53 C ATOM 258 CD GLN A 46 -29.032 1.323 7.822 1.00 85.31 C ATOM 259 OE1 GLN A 46 -27.827 1.376 8.079 1.00 89.29 O ATOM 260 NE2 GLN A 46 -29.575 0.326 7.123 1.00 84.72 N ATOM 261 N THR A 47 -33.708 1.110 10.519 1.00 76.36 N ATOM 262 CA THR A 47 -34.644 1.351 11.622 1.00 75.93 C ATOM 263 C THR A 47 -33.972 2.103 12.756 1.00 70.14 C ATOM 264 O THR A 47 -32.958 1.650 13.289 1.00 73.59 O ATOM 265 CB THR A 47 -35.262 0.058 12.194 1.00 77.84 C ATOM 266 OG1 THR A 47 -34.292 -1.002 12.174 1.00 78.37 O ATOM 267 CG2 THR A 47 -36.490 -0.333 11.401 1.00 76.26 C ATOM 268 N PRO A 48 -34.539 3.261 13.126 1.00 65.15 N ATOM 269 CA PRO A 48 -34.007 4.045 14.231 1.00 62.14 C ATOM 270 C PRO A 48 -34.314 3.403 15.579 1.00 58.95 C ATOM 271 O PRO A 48 -35.192 2.536 15.677 1.00 55.08 O ATOM 272 CB PRO A 48 -34.740 5.382 14.093 1.00 62.09 C ATOM 273 CG PRO A 48 -36.025 5.034 13.428 1.00 60.74 C ATOM 274 CD PRO A 48 -35.708 3.903 12.500 1.00 63.03 C ATOM 275 N VAL A 49 -33.566 3.831 16.593 1.00 55.70 N ATOM 276 CA VAL A 49 -33.742 3.395 17.969 1.00 55.62 C ATOM 277 C VAL A 49 -34.273 4.596 18.757 1.00 55.15 C ATOM 278 O VAL A 49 -33.726 5.695 18.668 1.00 54.24 O ATOM 279 CB VAL A 49 -32.401 2.887 18.569 1.00 58.77 C ATOM 280 CG1 VAL A 49 -32.482 2.684 20.084 1.00 58.77 C ATOM 281 CG2 VAL A 49 -31.971 1.601 17.885 1.00 60.91 C ATOM 282 N PHE A 50 -35.344 4.370 19.513 1.00 55.05 N ATOM 283 CA PHE A 50 -35.928 5.387 20.379 1.00 53.25 C ATOM 284 C PHE A 50 -35.051 5.580 21.608 1.00 52.78 C ATOM 285 O PHE A 50 -34.609 4.606 22.197 1.00 54.28 O ATOM 286 CB PHE A 50 -37.328 4.965 20.813 1.00 53.35 C ATOM 287 CG PHE A 50 -38.282 4.768 19.675 1.00 54.71 C ATOM 288 CD1 PHE A 50 -38.991 5.841 19.155 1.00 54.94 C ATOM 289 CD2 PHE A 50 -38.481 3.504 19.125 1.00 58.71 C ATOM 290 CE1 PHE A 50 -39.879 5.667 18.103 1.00 57.12 C ATOM 291 CE2 PHE A 50 -39.367 3.322 18.071 1.00 59.95 C ATOM 292 CZ PHE A 50 -40.069 4.406 17.560 1.00 58.39 C ATOM 293 N SER A 51 -34.799 6.835 21.978 1.00 52.30 N ATOM 294 CA SER A 51 -34.028 7.168 23.181 1.00 53.63 C ATOM 295 C SER A 51 -34.948 7.504 24.339 1.00 52.42 C ATOM 296 O SER A 51 -36.058 7.989 24.133 1.00 53.56 O ATOM 297 CB SER A 51 -33.107 8.359 22.929 1.00 52.22 C ATOM 298 OG SER A 51 -32.210 8.078 21.882 1.00 56.83 O ATOM 299 N LYS A 52 -34.469 7.263 25.555 1.00 50.90 N ATOM 300 CA LYS A 52 -35.263 7.483 26.753 1.00 50.31 C ATOM 301 C LYS A 52 -34.652 8.628 27.533 1.00 49.19 C ATOM 302 O LYS A 52 -33.431 8.826 27.516 1.00 47.66 O ATOM 303 CB LYS A 52 -35.296 6.227 27.626 1.00 53.07 C ATOM 304 CG LYS A 52 -35.454 4.915 26.866 1.00 57.44 C ATOM 305 CD LYS A 52 -36.842 4.312 26.986 1.00 62.32 C ATOM 306 CE LYS A 52 -36.920 3.320 28.145 1.00 67.96 C ATOM 307 NZ LYS A 52 -38.225 2.594 28.184 1.00 70.16 N ATOM 308 N ALA A 53 -35.499 9.377 28.227 1.00 45.76 N ATOM 309 CA ALA A 53 -35.024 10.462 29.077 1.00 47.48 C ATOM 310 C ALA A 53 -34.156 9.971 30.247 1.00 48.17 C ATOM 311 O ALA A 53 -34.552 9.081 31.004 1.00 44.60 O ATOM 312 CB ALA A 53 -36.196 11.282 29.589 1.00 46.26 C ATOM 313 N ARG A 54 -32.973 10.568 30.374 1.00 52.63 N ATOM 314 CA ARG A 54 -32.060 10.300 31.480 1.00 54.22 C ATOM 315 C ARG A 54 -32.618 10.808 32.815 1.00 51.48 C ATOM 316 O ARG A 54 -32.450 10.155 33.834 1.00 49.79 O ATOM 317 CB ARG A 54 -30.690 10.927 31.210 1.00 60.81 C ATOM 318 CG ARG A 54 -29.995 10.425 29.954 1.00 69.75 C ATOM 319 CD ARG A 54 -28.520 10.817 29.935 1.00 80.85 C ATOM 320 NE ARG A 54 -27.783 10.268 31.077 1.00 91.29 N ATOM 321 CZ ARG A 54 -27.232 9.054 31.115 1.00 98.09 C ATOM 322 NH1 ARG A 54 -27.320 8.237 30.070 1.00101.70 N ATOM 323 NH2 ARG A 54 -26.591 8.651 32.206 1.00 98.34 N ATOM 324 N TYR A 55 -33.271 11.971 32.798 1.00 50.67 N ATOM 325 CA TYR A 55 -33.877 12.561 33.997 1.00 52.16 C ATOM 326 C TYR A 55 -35.264 13.085 33.686 1.00 51.38 C ATOM 327 O TYR A 55 -35.524 13.503 32.553 1.00 52.54 O ATOM 328 CB TYR A 55 -33.064 13.760 34.506 1.00 56.01 C ATOM 329 CG TYR A 55 -31.563 13.586 34.572 1.00 62.11 C ATOM 330 CD1 TYR A 55 -30.969 12.794 35.554 1.00 66.49 C ATOM 331 CD2 TYR A 55 -30.733 14.249 33.670 1.00 63.11 C ATOM 332 CE1 TYR A 55 -29.587 12.651 35.616 1.00 69.90 C ATOM 333 CE2 TYR A 55 -29.355 14.119 33.724 1.00 65.65 C ATOM 334 CZ TYR A 55 -28.785 13.324 34.700 1.00 69.53 C ATOM 335 OH TYR A 55 -27.416 13.198 34.750 1.00 68.52 O ATOM 336 N THR A 56 -36.150 13.112 34.684 1.00 48.30 N ATOM 337 CA THR A 56 -37.396 13.846 34.512 1.00 44.20 C ATOM 338 C THR A 56 -37.067 15.332 34.634 1.00 44.64 C ATOM 339 O THR A 56 -36.153 15.695 35.371 1.00 44.17 O ATOM 340 CB THR A 56 -38.532 13.425 35.480 1.00 45.17 C ATOM 341 OG1 THR A 56 -38.751 14.422 36.484 1.00 43.38 O ATOM 342 CG2 THR A 56 -38.276 12.084 36.106 1.00 42.60 C ATOM 343 N VAL A 57 -37.770 16.176 33.876 1.00 43.47 N ATOM 344 CA VAL A 57 -37.519 17.624 33.878 1.00 43.76 C ATOM 345 C VAL A 57 -38.871 18.329 33.879 1.00 44.32 C ATOM 346 O VAL A 57 -39.488 18.527 32.834 1.00 47.43 O ATOM 347 CB VAL A 57 -36.637 18.098 32.687 1.00 42.50 C ATOM 348 CG1 VAL A 57 -36.313 19.578 32.818 1.00 39.87 C ATOM 349 CG2 VAL A 57 -35.339 17.301 32.591 1.00 38.96 C ATOM 350 N ARG A 58 -39.320 18.691 35.076 1.00 44.39 N ATOM 351 CA ARG A 58 -40.690 19.129 35.314 1.00 43.92 C ATOM 352 C ARG A 58 -41.144 20.214 34.358 1.00 43.55 C ATOM 353 O ARG A 58 -42.209 20.096 33.736 1.00 44.22 O ATOM 354 CB ARG A 58 -40.842 19.632 36.753 1.00 44.31 C ATOM 355 CG ARG A 58 -42.255 20.062 37.092 1.00 44.36 C ATOM 356 CD ARG A 58 -42.373 20.641 38.495 1.00 43.93 C ATOM 357 NE ARG A 58 -43.657 21.315 38.626 1.00 41.11 N ATOM 358 CZ ARG A 58 -43.864 22.579 38.271 1.00 45.30 C ATOM 359 NH1 ARG A 58 -42.862 23.308 37.782 1.00 45.57 N ATOM 360 NH2 ARG A 58 -45.073 23.121 38.408 1.00 47.87 N ATOM 361 N SER A 59 -40.336 21.267 34.253 1.00 41.64 N ATOM 362 CA SER A 59 -40.730 22.454 33.517 1.00 43.65 C ATOM 363 C SER A 59 -40.782 22.256 31.988 1.00 45.66 C ATOM 364 O SER A 59 -41.293 23.128 31.264 1.00 45.36 O ATOM 365 CB SER A 59 -39.835 23.628 33.905 1.00 43.64 C ATOM 366 OG SER A 59 -38.488 23.340 33.612 1.00 50.38 O ATOM 367 N PHE A 60 -40.266 21.116 31.512 1.00 44.66 N ATOM 368 CA PHE A 60 -40.311 20.757 30.091 1.00 45.29 C ATOM 369 C PHE A 60 -41.164 19.520 29.829 1.00 46.78 C ATOM 370 O PHE A 60 -41.191 18.995 28.712 1.00 49.02 O ATOM 371 CB PHE A 60 -38.905 20.559 29.521 1.00 43.02 C ATOM 372 CG PHE A 60 -38.177 21.846 29.234 1.00 42.26 C ATOM 373 CD1 PHE A 60 -38.279 22.457 27.986 1.00 43.51 C ATOM 374 CD2 PHE A 60 -37.380 22.441 30.204 1.00 42.34 C ATOM 375 CE1 PHE A 60 -37.605 23.646 27.716 1.00 44.93 C ATOM 376 CE2 PHE A 60 -36.697 23.626 29.940 1.00 44.25 C ATOM 377 CZ PHE A 60 -36.809 24.232 28.694 1.00 42.79 C ATOM 378 N GLY A 61 -41.861 19.051 30.856 1.00 45.07 N ATOM 379 CA GLY A 61 -42.793 17.942 30.695 1.00 43.72 C ATOM 380 C GLY A 61 -42.106 16.620 30.421 1.00 44.82 C ATOM 381 O GLY A 61 -42.722 15.701 29.877 1.00 41.29 O ATOM 382 N ILE A 62 -40.828 16.528 30.792 1.00 43.97 N ATOM 383 CA ILE A 62 -40.029 15.320 30.566 1.00 43.93 C ATOM 384 C ILE A 62 -40.092 14.382 31.774 1.00 46.16 C ATOM 385 O ILE A 62 -39.957 14.808 32.923 1.00 47.27 O ATOM 386 CB ILE A 62 -38.551 15.657 30.251 1.00 41.14 C ATOM 387 CG1 ILE A 62 -38.450 16.824 29.258 1.00 41.02 C ATOM 388 CG2 ILE A 62 -37.797 14.425 29.751 1.00 36.90 C ATOM 389 CD1 ILE A 62 -39.069 16.563 27.901 1.00 39.87 C ATOM 390 N ARG A 63 -40.311 13.108 31.491 1.00 49.79 N ATOM 391 CA ARG A 63 -40.385 12.066 32.500 1.00 53.88 C ATOM 392 C ARG A 63 -39.255 11.083 32.248 1.00 54.30 C ATOM 393 O ARG A 63 -39.058 10.625 31.112 1.00 55.09 O ATOM 394 CB ARG A 63 -41.722 11.345 32.384 1.00 59.88 C ATOM 395 CG ARG A 63 -42.190 10.622 33.635 1.00 67.93 C ATOM 396 CD ARG A 63 -43.670 10.271 33.534 1.00 73.40 C ATOM 397 NE ARG A 63 -44.438 11.334 32.877 1.00 81.52 N ATOM 398 CZ ARG A 63 -44.854 11.296 31.610 1.00 85.61 C ATOM 399 NH1 ARG A 63 -44.591 10.237 30.845 1.00 86.48 N ATOM 400 NH2 ARG A 63 -45.535 12.318 31.106 1.00 83.61 N ATOM 401 N ARG A 64 -38.509 10.776 33.306 1.00 51.72 N ATOM 402 CA ARG A 64 -37.425 9.805 33.268 1.00 47.35 C ATOM 403 C ARG A 64 -37.895 8.538 32.569 1.00 47.75 C ATOM 404 O ARG A 64 -39.045 8.114 32.741 1.00 44.11 O ATOM 405 CB ARG A 64 -36.994 9.488 34.697 1.00 48.67 C ATOM 406 CG ARG A 64 -35.835 8.522 34.839 1.00 52.40 C ATOM 407 CD ARG A 64 -35.680 8.067 36.290 1.00 56.03 C ATOM 408 NE ARG A 64 -35.119 6.717 36.365 1.00 53.88 N ATOM 409 CZ ARG A 64 -33.820 6.434 36.297 1.00 53.99 C ATOM 410 NH1 ARG A 64 -32.920 7.404 36.177 1.00 53.62 N ATOM 411 NH2 ARG A 64 -33.417 5.172 36.360 1.00 58.75 N ATOM 412 N ASN A 65 -37.010 7.952 31.762 1.00 48.20 N ATOM 413 CA ASN A 65 -37.273 6.671 31.098 1.00 51.84 C ATOM 414 C ASN A 65 -38.324 6.693 29.991 1.00 49.84 C ATOM 415 O ASN A 65 -38.551 5.672 29.345 1.00 49.27 O ATOM 416 CB ASN A 65 -37.589 5.556 32.111 1.00 55.00 C ATOM 417 CG ASN A 65 -36.338 4.978 32.751 1.00 61.28 C ATOM 418 OD1 ASN A 65 -35.295 4.860 32.105 1.00 62.42 O ATOM 419 ND2 ASN A 65 -36.437 4.609 34.030 1.00 64.83 N ATOM 420 N GLU A 66 -38.945 7.841 29.746 1.00 48.38 N ATOM 421 CA GLU A 66 -39.864 7.930 28.618 1.00 51.36 C ATOM 422 C GLU A 66 -39.106 7.991 27.283 1.00 46.76 C ATOM 423 O GLU A 66 -38.008 8.557 27.198 1.00 44.11 O ATOM 424 CB GLU A 66 -40.825 9.114 28.756 1.00 55.36 C ATOM 425 CG GLU A 66 -42.224 8.793 28.250 1.00 65.39 C ATOM 426 CD GLU A 66 -42.953 9.988 27.662 1.00 71.96 C ATOM 427 OE1 GLU A 66 -42.500 11.142 27.860 1.00 79.44 O ATOM 428 OE2 GLU A 66 -43.995 9.763 27.001 1.00 71.34 O ATOM 429 N LYS A 67 -39.691 7.383 26.254 1.00 45.46 N ATOM 430 CA LYS A 67 -39.172 7.488 24.894 1.00 44.10 C ATOM 431 C LYS A 67 -39.429 8.908 24.411 1.00 41.93 C ATOM 432 O LYS A 67 -40.561 9.382 24.446 1.00 42.22 O ATOM 433 CB LYS A 67 -39.841 6.464 23.983 1.00 47.43 C ATOM 434 CG LYS A 67 -39.481 5.023 24.319 1.00 52.78 C ATOM 435 CD LYS A 67 -40.183 4.017 23.414 1.00 59.33 C ATOM 436 CE LYS A 67 -41.630 3.768 23.827 1.00 64.01 C ATOM 437 NZ LYS A 67 -42.312 2.813 22.904 1.00 66.50 N ATOM 438 N ILE A 68 -38.376 9.599 23.987 1.00 39.23 N ATOM 439 CA ILE A 68 -38.484 11.025 23.692 1.00 39.57 C ATOM 440 C ILE A 68 -37.739 11.478 22.424 1.00 38.80 C ATOM 441 O ILE A 68 -37.855 12.638 22.006 1.00 39.25 O ATOM 442 CB ILE A 68 -38.033 11.886 24.902 1.00 38.93 C ATOM 443 CG1 ILE A 68 -36.598 11.558 25.295 1.00 37.83 C ATOM 444 CG2 ILE A 68 -38.972 11.698 26.090 1.00 39.81 C ATOM 445 CD1 ILE A 68 -35.958 12.623 26.161 1.00 40.73 C ATOM 446 N ALA A 69 -36.987 10.569 21.818 1.00 35.99 N ATOM 447 CA ALA A 69 -36.158 10.897 20.673 1.00 37.29 C ATOM 448 C ALA A 69 -35.867 9.638 19.874 1.00 39.38 C ATOM 449 O ALA A 69 -36.086 8.539 20.362 1.00 40.29 O ATOM 450 CB ALA A 69 -34.858 11.539 21.136 1.00 36.59 C ATOM 451 N VAL A 70 -35.368 9.809 18.648 1.00 41.71 N ATOM 452 CA VAL A 70 -34.954 8.693 17.792 1.00 40.39 C ATOM 453 C VAL A 70 -33.579 8.945 17.210 1.00 41.11 C ATOM 454 O VAL A 70 -33.252 10.063 16.836 1.00 39.46 O ATOM 455 CB VAL A 70 -35.926 8.443 16.625 1.00 40.90 C ATOM 456 CG1 VAL A 70 -37.070 7.563 17.070 1.00 41.45 C ATOM 457 CG2 VAL A 70 -36.449 9.753 16.056 1.00 39.50 C ATOM 458 N HIS A 71 -32.772 7.897 17.137 1.00 44.22 N ATOM 459 CA HIS A 71 -31.448 8.027 16.568 1.00 50.34 C ATOM 460 C HIS A 71 -31.099 6.857 15.703 1.00 52.31 C ATOM 461 O HIS A 71 -31.687 5.775 15.822 1.00 49.56 O ATOM 462 CB HIS A 71 -30.396 8.255 17.653 1.00 55.68 C ATOM 463 CG HIS A 71 -30.170 7.066 18.545 1.00 60.60 C ATOM 464 ND1 HIS A 71 -30.884 6.859 19.668 1.00 65.77 N ATOM 465 CD2 HIS A 71 -29.273 6.004 18.447 1.00 64.47 C ATOM 466 CE1 HIS A 71 -30.467 5.724 20.265 1.00 65.70 C ATOM 467 NE2 HIS A 71 -29.483 5.200 19.516 1.00 67.74 N ATOM 468 N CYS A 72 -30.134 7.079 14.817 1.00 52.11 N ATOM 469 CA CYS A 72 -29.737 6.093 13.836 1.00 55.01 C ATOM 470 C CYS A 72 -28.255 6.255 13.574 1.00 55.84 C ATOM 471 O CYS A 72 -27.745 7.377 13.537 1.00 53.83 O ATOM 472 CB CYS A 72 -30.511 6.304 12.535 1.00 57.27 C ATOM 473 SG CYS A 72 -30.723 4.803 11.558 1.00 67.71 S ATOM 474 N THR A 73 -27.568 5.130 13.405 1.00 56.23 N ATOM 475 CA THR A 73 -26.164 5.134 13.019 1.00 54.99 C ATOM 476 C THR A 73 -26.069 4.658 11.569 1.00 54.68 C ATOM 477 O THR A 73 -26.732 3.689 11.185 1.00 54.77 O ATOM 478 CB THR A 73 -25.319 4.243 13.964 1.00 54.85 C ATOM 479 OG1 THR A 73 -25.487 4.684 15.316 1.00 57.89 O ATOM 480 CG2 THR A 73 -23.850 4.323 13.628 1.00 51.49 C ATOM 481 N VAL A 74 -25.288 5.370 10.758 1.00 53.49 N ATOM 482 CA VAL A 74 -25.008 4.942 9.380 1.00 51.10 C ATOM 483 C VAL A 74 -23.518 4.961 9.101 1.00 51.62 C ATOM 484 O VAL A 74 -22.784 5.802 9.641 1.00 50.47 O ATOM 485 CB VAL A 74 -25.758 5.761 8.299 1.00 50.74 C ATOM 486 CG1 VAL A 74 -27.203 5.299 8.188 1.00 48.88 C ATOM 487 CG2 VAL A 74 -25.676 7.258 8.572 1.00 52.91 C ATOM 488 N ARG A 75 -23.085 4.018 8.269 1.00 50.21 N ATOM 489 CA ARG A 75 -21.682 3.898 7.885 1.00 50.35 C ATOM 490 C ARG A 75 -21.563 3.874 6.359 1.00 52.24 C ATOM 491 O ARG A 75 -22.583 3.837 5.646 1.00 49.84 O ATOM 492 CB ARG A 75 -21.075 2.634 8.488 1.00 48.96 C ATOM 493 CG ARG A 75 -21.360 2.478 9.972 1.00 49.47 C ATOM 494 CD ARG A 75 -20.720 1.231 10.561 1.00 49.85 C ATOM 495 NE ARG A 75 -20.874 1.182 12.017 1.00 49.58 N ATOM 496 CZ ARG A 75 -20.006 1.695 12.887 1.00 50.34 C ATOM 497 NH1 ARG A 75 -18.901 2.307 12.458 1.00 48.76 N ATOM 498 NH2 ARG A 75 -20.243 1.596 14.196 1.00 49.18 N ATOM 499 N GLY A 76 -20.321 3.925 5.873 1.00 50.32 N ATOM 500 CA GLY A 76 -20.013 3.759 4.453 1.00 48.05 C ATOM 501 C GLY A 76 -20.623 4.802 3.541 1.00 49.54 C ATOM 502 O GLY A 76 -20.789 5.964 3.927 1.00 52.84 O ATOM 503 N ALA A 77 -20.966 4.382 2.327 1.00 47.63 N ATOM 504 CA ALA A 77 -21.454 5.303 1.300 1.00 47.63 C ATOM 505 C ALA A 77 -22.689 6.081 1.749 1.00 44.92 C ATOM 506 O ALA A 77 -22.856 7.256 1.407 1.00 43.33 O ATOM 507 CB ALA A 77 -21.725 4.552 -0.001 1.00 48.78 C ATOM 508 N LYS A 78 -23.538 5.419 2.530 1.00 47.92 N ATOM 509 CA LYS A 78 -24.779 6.017 3.036 1.00 50.45 C ATOM 510 C LYS A 78 -24.488 7.208 3.965 1.00 49.38 C ATOM 511 O LYS A 78 -25.166 8.243 3.899 1.00 50.54 O ATOM 512 CB LYS A 78 -25.629 4.947 3.740 1.00 51.74 C ATOM 513 CG LYS A 78 -26.990 5.413 4.259 1.00 57.78 C ATOM 514 CD LYS A 78 -28.130 5.279 3.247 1.00 60.09 C ATOM 515 CE LYS A 78 -28.242 6.500 2.343 1.00 62.47 C ATOM 516 NZ LYS A 78 -29.552 6.562 1.631 1.00 67.14 N ATOM 517 N ALA A 79 -23.461 7.056 4.803 1.00 47.54 N ATOM 518 CA ALA A 79 -23.042 8.101 5.731 1.00 48.55 C ATOM 519 C ALA A 79 -22.529 9.335 4.997 1.00 48.23 C ATOM 520 O ALA A 79 -22.962 10.452 5.287 1.00 49.03 O ATOM 521 CB ALA A 79 -22.001 7.570 6.702 1.00 48.29 C ATOM 522 N GLU A 80 -21.625 9.128 4.039 1.00 49.55 N ATOM 523 CA GLU A 80 -21.109 10.210 3.192 1.00 48.71 C ATOM 524 C GLU A 80 -22.225 11.018 2.538 1.00 47.97 C ATOM 525 O GLU A 80 -22.203 12.254 2.535 1.00 51.01 O ATOM 526 CB GLU A 80 -20.196 9.643 2.108 1.00 53.28 C ATOM 527 CG GLU A 80 -18.891 9.076 2.639 1.00 57.34 C ATOM 528 CD GLU A 80 -17.905 8.770 1.535 1.00 63.34 C ATOM 529 OE1 GLU A 80 -17.618 7.572 1.311 1.00 66.80 O ATOM 530 OE2 GLU A 80 -17.428 9.729 0.886 1.00 70.45 O ATOM 531 N GLU A 81 -23.206 10.309 1.999 1.00 46.19 N ATOM 532 CA GLU A 81 -24.295 10.924 1.258 1.00 45.72 C ATOM 533 C GLU A 81 -25.143 11.827 2.154 1.00 44.77 C ATOM 534 O GLU A 81 -25.412 12.987 1.817 1.00 48.68 O ATOM 535 CB GLU A 81 -25.152 9.821 0.629 1.00 47.54 C ATOM 536 CG GLU A 81 -26.236 10.328 -0.303 1.00 52.57 C ATOM 537 CD GLU A 81 -27.297 9.288 -0.613 1.00 56.84 C ATOM 538 OE1 GLU A 81 -28.488 9.587 -0.393 1.00 63.24 O ATOM 539 OE2 GLU A 81 -26.948 8.180 -1.077 1.00 57.06 O ATOM 540 N ILE A 82 -25.566 11.283 3.295 1.00 43.05 N ATOM 541 CA ILE A 82 -26.386 12.019 4.261 1.00 40.26 C ATOM 542 C ILE A 82 -25.632 13.229 4.837 1.00 38.65 C ATOM 543 O ILE A 82 -26.188 14.335 4.895 1.00 37.37 O ATOM 544 CB ILE A 82 -26.935 11.078 5.350 1.00 40.47 C ATOM 545 CG1 ILE A 82 -27.956 10.119 4.722 1.00 42.11 C ATOM 546 CG2 ILE A 82 -27.579 11.873 6.472 1.00 39.99 C ATOM 547 CD1 ILE A 82 -28.104 8.797 5.438 1.00 42.40 C ATOM 548 N LEU A 83 -24.363 13.031 5.200 1.00 35.93 N ATOM 549 CA LEU A 83 -23.492 14.136 5.617 1.00 38.96 C ATOM 550 C LEU A 83 -23.457 15.269 4.608 1.00 41.59 C ATOM 551 O LEU A 83 -23.576 16.453 4.982 1.00 41.75 O ATOM 552 CB LEU A 83 -22.062 13.650 5.870 1.00 39.89 C ATOM 553 CG LEU A 83 -21.081 14.727 6.351 1.00 42.37 C ATOM 554 CD1 LEU A 83 -21.570 15.428 7.619 1.00 40.96 C ATOM 555 CD2 LEU A 83 -19.676 14.156 6.544 1.00 42.06 C ATOM 556 N GLU A 84 -23.290 14.908 3.332 1.00 41.85 N ATOM 557 CA GLU A 84 -23.235 15.899 2.259 1.00 40.28 C ATOM 558 C GLU A 84 -24.520 16.689 2.159 1.00 39.30 C ATOM 559 O GLU A 84 -24.478 17.914 2.025 1.00 39.64 O ATOM 560 CB GLU A 84 -22.922 15.244 0.926 1.00 41.56 C ATOM 561 CG GLU A 84 -21.466 14.866 0.797 1.00 43.94 C ATOM 562 CD GLU A 84 -21.193 14.014 -0.417 1.00 45.69 C ATOM 563 OE1 GLU A 84 -20.352 13.092 -0.317 1.00 45.72 O ATOM 564 OE2 GLU A 84 -21.815 14.275 -1.469 1.00 48.01 O ATOM 565 N LYS A 85 -25.657 15.993 2.224 1.00 38.67 N ATOM 566 CA LYS A 85 -26.959 16.663 2.263 1.00 39.63 C ATOM 567 C LYS A 85 -27.003 17.666 3.419 1.00 39.72 C ATOM 568 O LYS A 85 -27.355 18.832 3.218 1.00 42.20 O ATOM 569 CB LYS A 85 -28.098 15.656 2.381 1.00 44.16 C ATOM 570 CG LYS A 85 -28.368 14.846 1.123 1.00 45.07 C ATOM 571 CD LYS A 85 -29.285 13.682 1.458 1.00 46.49 C ATOM 572 CE LYS A 85 -29.707 12.908 0.217 1.00 48.73 C ATOM 573 NZ LYS A 85 -30.614 11.785 0.592 1.00 53.45 N ATOM 574 N GLY A 86 -26.582 17.232 4.607 1.00 36.98 N ATOM 575 CA GLY A 86 -26.520 18.109 5.765 1.00 34.92 C ATOM 576 C GLY A 86 -25.600 19.301 5.576 1.00 37.83 C ATOM 577 O GLY A 86 -25.974 20.445 5.882 1.00 41.06 O ATOM 578 N LEU A 87 -24.394 19.048 5.082 1.00 36.91 N ATOM 579 CA LEU A 87 -23.442 20.126 4.830 1.00 37.29 C ATOM 580 C LEU A 87 -23.938 21.127 3.795 1.00 40.48 C ATOM 581 O LEU A 87 -23.735 22.331 3.950 1.00 43.13 O ATOM 582 CB LEU A 87 -22.094 19.565 4.403 1.00 36.87 C ATOM 583 CG LEU A 87 -21.313 18.878 5.512 1.00 36.42 C ATOM 584 CD1 LEU A 87 -20.106 18.157 4.933 1.00 35.50 C ATOM 585 CD2 LEU A 87 -20.909 19.890 6.575 1.00 35.71 C ATOM 586 N LYS A 88 -24.583 20.635 2.739 1.00 41.81 N ATOM 587 CA LYS A 88 -25.141 21.518 1.724 1.00 42.57 C ATOM 588 C LYS A 88 -26.181 22.435 2.357 1.00 42.75 C ATOM 589 O LYS A 88 -26.209 23.632 2.082 1.00 44.80 O ATOM 590 CB LYS A 88 -25.716 20.706 0.548 1.00 45.51 C ATOM 591 CG LYS A 88 -26.908 21.305 -0.200 1.00 46.93 C ATOM 592 CD LYS A 88 -26.557 22.485 -1.105 1.00 50.10 C ATOM 593 CE LYS A 88 -27.658 22.775 -2.130 1.00 52.25 C ATOM 594 NZ LYS A 88 -29.024 22.252 -1.781 1.00 51.89 N ATOM 595 N VAL A 89 -27.034 21.878 3.211 1.00 43.87 N ATOM 596 CA VAL A 89 -28.012 22.700 3.916 1.00 44.45 C ATOM 597 C VAL A 89 -27.297 23.783 4.724 1.00 45.85 C ATOM 598 O VAL A 89 -27.767 24.927 4.778 1.00 42.57 O ATOM 599 CB VAL A 89 -28.921 21.877 4.850 1.00 43.71 C ATOM 600 CG1 VAL A 89 -29.846 22.803 5.630 1.00 40.84 C ATOM 601 CG2 VAL A 89 -29.738 20.877 4.052 1.00 43.16 C ATOM 602 N ARG A 90 -26.160 23.414 5.328 1.00 43.40 N ATOM 603 CA ARG A 90 -25.355 24.348 6.111 1.00 43.11 C ATOM 604 C ARG A 90 -24.433 25.202 5.239 1.00 45.09 C ATOM 605 O ARG A 90 -23.622 25.980 5.754 1.00 43.70 O ATOM 606 CB ARG A 90 -24.536 23.588 7.164 1.00 44.32 C ATOM 607 CG ARG A 90 -25.363 22.976 8.299 1.00 43.35 C ATOM 608 CD ARG A 90 -25.966 24.051 9.189 1.00 40.86 C ATOM 609 NE ARG A 90 -24.930 24.919 9.744 1.00 41.72 N ATOM 610 CZ ARG A 90 -24.398 24.799 10.963 1.00 41.35 C ATOM 611 NH1 ARG A 90 -24.814 23.852 11.794 1.00 39.68 N ATOM 612 NH2 ARG A 90 -23.456 25.648 11.356 1.00 39.94 N ATOM 613 N GLU A 91 -24.559 25.053 3.921 1.00 45.62 N ATOM 614 CA GLU A 91 -23.688 25.737 2.964 1.00 50.12 C ATOM 615 C GLU A 91 -22.200 25.484 3.248 1.00 52.12 C ATOM 616 O GLU A 91 -21.375 26.399 3.153 1.00 51.99 O ATOM 617 CB GLU A 91 -23.982 27.240 2.929 1.00 53.58 C ATOM 618 CG GLU A 91 -25.344 27.598 2.365 1.00 61.45 C ATOM 619 CD GLU A 91 -25.741 29.022 2.699 1.00 71.38 C ATOM 620 OE1 GLU A 91 -25.881 29.340 3.905 1.00 77.03 O ATOM 621 OE2 GLU A 91 -25.914 29.825 1.754 1.00 75.81 O ATOM 622 N TYR A 92 -21.875 24.243 3.611 1.00 52.14 N ATOM 623 CA TYR A 92 -20.489 23.804 3.833 1.00 52.11 C ATOM 624 C TYR A 92 -19.745 24.693 4.844 1.00 51.86 C ATOM 625 O TYR A 92 -18.536 24.887 4.770 1.00 54.43 O ATOM 626 CB TYR A 92 -19.749 23.635 2.485 1.00 53.04 C ATOM 627 CG TYR A 92 -20.394 22.556 1.627 1.00 54.72 C ATOM 628 CD1 TYR A 92 -20.112 21.204 1.846 1.00 54.99 C ATOM 629 CD2 TYR A 92 -21.326 22.880 0.635 1.00 54.22 C ATOM 630 CE1 TYR A 92 -20.720 20.208 1.091 1.00 58.17 C ATOM 631 CE2 TYR A 92 -21.942 21.891 -0.127 1.00 54.59 C ATOM 632 CZ TYR A 92 -21.638 20.557 0.103 1.00 59.83 C ATOM 633 OH TYR A 92 -22.241 19.560 -0.645 1.00 61.86 O ATOM 634 N GLU A 93 -20.491 25.200 5.816 1.00 50.28 N ATOM 635 CA GLU A 93 -19.959 26.161 6.759 1.00 50.98 C ATOM 636 C GLU A 93 -20.323 25.818 8.209 1.00 47.91 C ATOM 637 O GLU A 93 -21.493 25.898 8.607 1.00 48.09 O ATOM 638 CB GLU A 93 -20.459 27.555 6.387 1.00 50.04 C ATOM 639 CG GLU A 93 -19.991 28.656 7.306 1.00 52.96 C ATOM 640 CD GLU A 93 -20.954 29.813 7.300 1.00 59.70 C ATOM 641 OE1 GLU A 93 -21.822 29.859 8.205 1.00 64.28 O ATOM 642 OE2 GLU A 93 -20.863 30.647 6.375 1.00 59.77 O ATOM 643 N LEU A 94 -19.301 25.444 8.978 1.00 43.06 N ATOM 644 CA LEU A 94 -19.428 25.130 10.405 1.00 43.33 C ATOM 645 C LEU A 94 -18.627 26.146 11.261 1.00 44.34 C ATOM 646 O LEU A 94 -18.032 27.076 10.714 1.00 43.31 O ATOM 647 CB LEU A 94 -18.986 23.677 10.676 1.00 39.91 C ATOM 648 CG LEU A 94 -19.683 22.529 9.907 1.00 39.54 C ATOM 649 CD1 LEU A 94 -18.981 21.196 10.112 1.00 37.39 C ATOM 650 CD2 LEU A 94 -21.162 22.388 10.239 1.00 37.04 C ATOM 651 N ARG A 95 -18.653 25.988 12.590 1.00 44.82 N ATOM 652 CA ARG A 95 -17.838 26.780 13.529 1.00 43.55 C ATOM 653 C ARG A 95 -16.815 25.858 14.143 1.00 43.34 C ATOM 654 O ARG A 95 -17.038 24.651 14.198 1.00 43.01 O ATOM 655 CB ARG A 95 -18.684 27.306 14.685 1.00 44.01 C ATOM 656 CG ARG A 95 -19.647 28.417 14.355 1.00 45.01 C ATOM 657 CD ARG A 95 -19.112 29.766 14.792 1.00 45.89 C ATOM 658 NE ARG A 95 -19.937 30.812 14.202 1.00 48.25 N ATOM 659 CZ ARG A 95 -19.529 32.048 13.948 1.00 49.01 C ATOM 660 NH1 ARG A 95 -18.285 32.414 14.240 1.00 50.17 N ATOM 661 NH2 ARG A 95 -20.375 32.915 13.401 1.00 48.10 N ATOM 662 N LYS A 96 -15.718 26.429 14.645 1.00 45.49 N ATOM 663 CA LYS A 96 -14.730 25.667 15.405 1.00 46.03 C ATOM 664 C LYS A 96 -15.366 24.960 16.604 1.00 46.40 C ATOM 665 O LYS A 96 -14.893 23.907 17.009 1.00 47.34 O ATOM 666 CB LYS A 96 -13.571 26.559 15.857 1.00 49.26 C ATOM 667 CG LYS A 96 -12.376 25.784 16.397 1.00 52.62 C ATOM 668 CD LYS A 96 -11.227 26.702 16.777 1.00 57.28 C ATOM 669 CE LYS A 96 -10.002 25.891 17.174 1.00 63.26 C ATOM 670 NZ LYS A 96 -8.799 26.727 17.456 1.00 67.92 N ATOM 671 N ASN A 97 -16.434 25.547 17.154 1.00 48.20 N ATOM 672 CA ASN A 97 -17.233 24.943 18.240 1.00 49.05 C ATOM 673 C ASN A 97 -17.750 23.545 17.896 1.00 49.66 C ATOM 674 O ASN A 97 -17.893 22.696 18.779 1.00 48.77 O ATOM 675 CB ASN A 97 -18.453 25.815 18.602 1.00 48.97 C ATOM 676 CG ASN A 97 -18.077 27.227 19.038 1.00 52.17 C ATOM 677 OD1 ASN A 97 -17.514 28.008 18.266 1.00 51.08 O ATOM 678 ND2 ASN A 97 -18.423 27.573 20.274 1.00 50.75 N ATOM 679 N ASN A 98 -18.053 23.320 16.617 1.00 47.62 N ATOM 680 CA ASN A 98 -18.628 22.054 16.169 1.00 44.52 C ATOM 681 C ASN A 98 -17.624 20.916 16.242 1.00 43.82 C ATOM 682 O ASN A 98 -18.007 19.750 16.223 1.00 43.26 O ATOM 683 CB ASN A 98 -19.165 22.186 14.741 1.00 44.47 C ATOM 684 CG ASN A 98 -20.433 23.014 14.662 1.00 44.66 C ATOM 685 OD1 ASN A 98 -21.451 22.681 15.264 1.00 44.87 O ATOM 686 ND2 ASN A 98 -20.383 24.091 13.896 1.00 44.12 N ATOM 687 N PHE A 99 -16.340 21.258 16.331 1.00 43.38 N ATOM 688 CA PHE A 99 -15.276 20.257 16.321 1.00 47.39 C ATOM 689 C PHE A 99 -14.786 19.892 17.722 1.00 52.02 C ATOM 690 O PHE A 99 -14.278 20.741 18.457 1.00 53.06 O ATOM 691 CB PHE A 99 -14.103 20.716 15.447 1.00 44.58 C ATOM 692 CG PHE A 99 -14.403 20.704 13.974 1.00 44.23 C ATOM 693 CD1 PHE A 99 -13.939 19.666 13.166 1.00 43.97 C ATOM 694 CD2 PHE A 99 -15.157 21.731 13.390 1.00 41.79 C ATOM 695 CE1 PHE A 99 -14.218 19.652 11.801 1.00 43.42 C ATOM 696 CE2 PHE A 99 -15.434 21.722 12.032 1.00 42.71 C ATOM 697 CZ PHE A 99 -14.965 20.685 11.237 1.00 43.18 C ATOM 698 N SER A 100 -14.935 18.619 18.077 1.00 53.14 N ATOM 699 CA SER A 100 -14.470 18.112 19.360 1.00 53.10 C ATOM 700 C SER A 100 -12.953 18.001 19.421 1.00 54.31 C ATOM 701 O SER A 100 -12.274 17.987 18.389 1.00 51.87 O ATOM 702 CB SER A 100 -15.105 16.754 19.640 1.00 54.98 C ATOM 703 OG SER A 100 -16.499 16.910 19.856 1.00 58.44 O ATOM 704 N ASP A 101 -12.427 17.911 20.640 1.00 56.88 N ATOM 705 CA ASP A 101 -10.992 17.755 20.845 1.00 59.52 C ATOM 706 C ASP A 101 -10.484 16.381 20.395 1.00 56.97 C ATOM 707 O ASP A 101 -9.276 16.154 20.328 1.00 56.47 O ATOM 708 CB ASP A 101 -10.622 18.057 22.300 1.00 64.82 C ATOM 709 CG ASP A 101 -10.555 19.558 22.584 1.00 72.77 C ATOM 710 OD1 ASP A 101 -9.567 20.206 22.158 1.00 72.05 O ATOM 711 OD2 ASP A 101 -11.489 20.090 23.229 1.00 74.35 O ATOM 712 N THR A 102 -11.415 15.497 20.042 1.00 54.50 N ATOM 713 CA THR A 102 -11.104 14.116 19.638 1.00 58.14 C ATOM 714 C THR A 102 -10.919 13.948 18.130 1.00 57.66 C ATOM 715 O THR A 102 -10.561 12.868 17.652 1.00 57.43 O ATOM 716 CB THR A 102 -12.234 13.165 20.049 1.00 57.17 C ATOM 717 OG1 THR A 102 -13.490 13.729 19.647 1.00 61.94 O ATOM 718 CG2 THR A 102 -12.235 12.971 21.542 1.00 57.60 C ATOM 719 N GLY A 103 -11.176 15.014 17.382 1.00 59.06 N ATOM 720 CA GLY A 103 -11.162 14.932 15.928 1.00 60.50 C ATOM 721 C GLY A 103 -12.473 14.434 15.332 1.00 58.89 C ATOM 722 O GLY A 103 -12.497 13.947 14.201 1.00 63.87 O ATOM 723 N ASN A 104 -13.554 14.537 16.098 1.00 48.62 N ATOM 724 CA ASN A 104 -14.894 14.346 15.573 1.00 45.83 C ATOM 725 C ASN A 104 -15.611 15.681 15.578 1.00 44.54 C ATOM 726 O ASN A 104 -15.102 16.669 16.134 1.00 44.16 O ATOM 727 CB ASN A 104 -15.681 13.355 16.421 1.00 44.66 C ATOM 728 CG ASN A 104 -14.949 12.051 16.625 1.00 44.86 C ATOM 729 OD1 ASN A 104 -14.283 11.539 15.720 1.00 46.08 O ATOM 730 ND2 ASN A 104 -15.068 11.505 17.820 1.00 41.70 N ATOM 731 N PHE A 105 -16.794 15.711 14.970 1.00 40.54 N ATOM 732 CA PHE A 105 -17.554 16.947 14.855 1.00 38.13 C ATOM 733 C PHE A 105 -19.014 16.666 14.537 1.00 39.02 C ATOM 734 O PHE A 105 -19.351 15.594 14.007 1.00 38.06 O ATOM 735 CB PHE A 105 -16.937 17.848 13.777 1.00 38.44 C ATOM 736 CG PHE A 105 -17.065 17.299 12.379 1.00 39.62 C ATOM 737 CD1 PHE A 105 -16.178 16.333 11.907 1.00 39.41 C ATOM 738 CD2 PHE A 105 -18.071 17.752 11.535 1.00 38.87 C ATOM 739 CE1 PHE A 105 -16.307 15.825 10.623 1.00 41.14 C ATOM 740 CE2 PHE A 105 -18.205 17.247 10.255 1.00 39.19 C ATOM 741 CZ PHE A 105 -17.322 16.285 9.797 1.00 40.05 C ATOM 742 N GLY A 106 -19.878 17.637 14.845 1.00 35.82 N ATOM 743 CA GLY A 106 -21.286 17.501 14.542 1.00 32.74 C ATOM 744 C GLY A 106 -21.924 18.850 14.344 1.00 32.56 C ATOM 745 O GLY A 106 -21.257 19.867 14.420 1.00 33.16 O ATOM 746 N PHE A 107 -23.228 18.859 14.088 1.00 31.27 N ATOM 747 CA PHE A 107 -23.934 20.096 13.801 1.00 31.45 C ATOM 748 C PHE A 107 -25.401 19.794 13.712 1.00 30.72 C ATOM 749 O PHE A 107 -25.789 18.632 13.592 1.00 33.22 O ATOM 750 CB PHE A 107 -23.440 20.741 12.489 1.00 32.40 C ATOM 751 CG PHE A 107 -23.660 19.894 11.257 1.00 33.43 C ATOM 752 CD1 PHE A 107 -24.831 20.017 10.511 1.00 34.11 C ATOM 753 CD2 PHE A 107 -22.702 18.982 10.843 1.00 31.93 C ATOM 754 CE1 PHE A 107 -25.039 19.245 9.370 1.00 34.86 C ATOM 755 CE2 PHE A 107 -22.906 18.210 9.711 1.00 35.49 C ATOM 756 CZ PHE A 107 -24.076 18.339 8.968 1.00 34.63 C ATOM 757 N GLY A 108 -26.210 20.838 13.770 1.00 30.82 N ATOM 758 CA GLY A 108 -27.640 20.695 13.566 1.00 33.55 C ATOM 759 C GLY A 108 -28.152 21.486 12.377 1.00 35.75 C ATOM 760 O GLY A 108 -27.493 22.418 11.880 1.00 36.58 O ATOM 761 N ILE A 109 -29.332 21.100 11.908 1.00 37.40 N ATOM 762 CA ILE A 109 -30.059 21.856 10.889 1.00 39.36 C ATOM 763 C ILE A 109 -31.475 22.065 11.427 1.00 42.53 C ATOM 764 O ILE A 109 -32.001 21.184 12.132 1.00 41.80 O ATOM 765 CB ILE A 109 -30.066 21.130 9.516 1.00 40.75 C ATOM 766 CG1 ILE A 109 -30.731 19.752 9.626 1.00 42.43 C ATOM 767 CG2 ILE A 109 -28.648 20.971 8.970 1.00 36.82 C ATOM 768 CD1 ILE A 109 -31.173 19.173 8.300 1.00 43.03 C ATOM 769 N GLN A 110 -32.085 23.219 11.131 1.00 44.10 N ATOM 770 CA GLN A 110 -33.432 23.511 11.646 1.00 46.84 C ATOM 771 C GLN A 110 -34.550 22.649 11.073 1.00 47.40 C ATOM 772 O GLN A 110 -35.496 22.311 11.790 1.00 48.66 O ATOM 773 CB GLN A 110 -33.819 24.977 11.452 1.00 51.40 C ATOM 774 CG GLN A 110 -33.580 25.862 12.663 1.00 57.48 C ATOM 775 CD GLN A 110 -32.348 26.742 12.509 1.00 65.85 C ATOM 776 OE1 GLN A 110 -32.081 27.603 13.351 1.00 71.01 O ATOM 777 NE2 GLN A 110 -31.594 26.539 11.425 1.00 64.53 N ATOM 778 N GLU A 111 -34.475 22.328 9.783 1.00 47.25 N ATOM 779 CA GLU A 111 -35.622 21.704 9.107 1.00 47.69 C ATOM 780 C GLU A 111 -35.172 20.552 8.238 1.00 45.01 C ATOM 781 O GLU A 111 -34.306 20.717 7.378 1.00 45.28 O ATOM 782 CB GLU A 111 -36.398 22.719 8.268 1.00 49.51 C ATOM 783 CG GLU A 111 -36.736 24.014 8.993 1.00 55.51 C ATOM 784 CD GLU A 111 -37.736 24.880 8.247 1.00 59.98 C ATOM 785 OE1 GLU A 111 -38.146 25.913 8.821 1.00 59.24 O ATOM 786 OE2 GLU A 111 -38.117 24.533 7.099 1.00 62.56 O ATOM 787 N HIS A 112 -35.768 19.389 8.472 1.00 40.62 N ATOM 788 CA HIS A 112 -35.349 18.163 7.812 1.00 44.17 C ATOM 789 C HIS A 112 -35.734 18.147 6.344 1.00 45.83 C ATOM 790 O HIS A 112 -35.141 17.419 5.551 1.00 47.32 O ATOM 791 CB HIS A 112 -35.979 16.975 8.521 1.00 41.09 C ATOM 792 CG HIS A 112 -37.465 16.876 8.308 1.00 40.21 C ATOM 793 ND1 HIS A 112 -38.020 15.952 7.496 1.00 41.66 N ATOM 794 CD2 HIS A 112 -38.515 17.651 8.805 1.00 39.23 C ATOM 795 CE1 HIS A 112 -39.367 16.106 7.497 1.00 41.30 C ATOM 796 NE2 HIS A 112 -39.666 17.147 8.299 1.00 39.06 N ATOM 797 N ILE A 113 -36.745 18.935 5.980 1.00 45.01 N ATOM 798 CA ILE A 113 -37.225 19.005 4.598 1.00 46.83 C ATOM 799 C ILE A 113 -36.129 19.492 3.626 1.00 48.18 C ATOM 800 O ILE A 113 -36.149 19.169 2.434 1.00 52.95 O ATOM 801 CB ILE A 113 -38.534 19.831 4.481 1.00 46.38 C ATOM 802 CG1 ILE A 113 -38.342 21.275 4.966 1.00 45.08 C ATOM 803 CG2 ILE A 113 -39.656 19.170 5.282 1.00 44.45 C ATOM 804 CD1 ILE A 113 -39.501 22.190 4.613 1.00 42.40 C ATOM 805 N ASP A 114 -35.160 20.230 4.163 1.00 45.11 N ATOM 806 CA ASP A 114 -34.033 20.751 3.406 1.00 44.68 C ATOM 807 C ASP A 114 -33.038 19.683 2.930 1.00 46.38 C ATOM 808 O ASP A 114 -32.176 19.973 2.101 1.00 49.58 O ATOM 809 CB ASP A 114 -33.307 21.832 4.216 1.00 42.98 C ATOM 810 CG ASP A 114 -34.167 23.063 4.460 1.00 44.89 C ATOM 811 OD1 ASP A 114 -35.334 23.096 3.998 1.00 47.40 O ATOM 812 OD2 ASP A 114 -33.677 24.006 5.119 1.00 44.08 O ATOM 813 N LEU A 115 -33.141 18.465 3.460 1.00 46.65 N ATOM 814 CA LEU A 115 -32.378 17.335 2.926 1.00 49.75 C ATOM 815 C LEU A 115 -33.061 16.742 1.684 1.00 52.45 C ATOM 816 O LEU A 115 -32.520 15.842 1.032 1.00 52.29 O ATOM 817 CB LEU A 115 -32.228 16.221 3.969 1.00 48.85 C ATOM 818 CG LEU A 115 -31.280 16.249 5.176 1.00 48.62 C ATOM 819 CD1 LEU A 115 -30.235 17.360 5.145 1.00 46.54 C ATOM 820 CD2 LEU A 115 -32.107 16.308 6.441 1.00 46.43 C ATOM 821 N GLY A 116 -34.264 17.232 1.392 1.00 51.68 N ATOM 822 CA GLY A 116 -35.053 16.757 0.272 1.00 54.78 C ATOM 823 C GLY A 116 -36.181 15.810 0.642 1.00 57.96 C ATOM 824 O GLY A 116 -36.604 14.994 -0.176 1.00 58.05 O ATOM 825 N ILE A 117 -36.661 15.904 1.876 1.00 56.82 N ATOM 826 CA ILE A 117 -37.810 15.130 2.301 1.00 56.45 C ATOM 827 C ILE A 117 -39.012 16.045 2.073 1.00 58.88 C ATOM 828 O ILE A 117 -38.960 17.224 2.424 1.00 60.09 O ATOM 829 CB ILE A 117 -37.693 14.716 3.793 1.00 55.54 C ATOM 830 CG1 ILE A 117 -36.357 14.003 4.076 1.00 55.47 C ATOM 831 CG2 ILE A 117 -38.891 13.885 4.237 1.00 49.97 C ATOM 832 CD1 ILE A 117 -36.345 12.515 3.793 1.00 63.56 C ATOM 833 N LYS A 118 -40.077 15.517 1.472 1.00 56.78 N ATOM 834 CA LYS A 118 -41.287 16.307 1.212 1.00 57.94 C ATOM 835 C LYS A 118 -41.957 16.795 2.498 1.00 56.86 C ATOM 836 O LYS A 118 -42.088 16.028 3.453 1.00 56.99 O ATOM 837 CB LYS A 118 -42.293 15.479 0.413 1.00 55.02 C ATOM 838 N TYR A 119 -42.383 18.059 2.514 1.00 56.97 N ATOM 839 CA TYR A 119 -43.194 18.591 3.613 1.00 60.61 C ATOM 840 C TYR A 119 -44.610 18.024 3.610 1.00 64.42 C ATOM 841 O TYR A 119 -45.277 18.006 2.577 1.00 66.40 O ATOM 842 CB TYR A 119 -43.254 20.125 3.581 1.00 63.42 C ATOM 843 CG TYR A 119 -44.255 20.726 4.559 1.00 67.35 C ATOM 844 CD1 TYR A 119 -43.985 20.771 5.930 1.00 67.87 C ATOM 845 CD2 TYR A 119 -45.472 21.251 4.112 1.00 69.35 C ATOM 846 CE1 TYR A 119 -44.893 21.316 6.827 1.00 68.47 C ATOM 847 CE2 TYR A 119 -46.388 21.797 5.002 1.00 71.37 C ATOM 848 CZ TYR A 119 -46.093 21.829 6.358 1.00 73.30 C ATOM 849 OH TYR A 119 -46.997 22.371 7.248 1.00 72.93 O ATOM 850 N ASP A 120 -45.050 17.558 4.775 1.00 68.00 N ATOM 851 CA ASP A 120 -46.434 17.155 4.993 1.00 72.11 C ATOM 852 C ASP A 120 -46.973 17.957 6.183 1.00 74.36 C ATOM 853 O ASP A 120 -46.404 17.886 7.275 1.00 75.90 O ATOM 854 CB ASP A 120 -46.510 15.646 5.267 1.00 73.89 C ATOM 855 CG ASP A 120 -47.931 15.083 5.166 1.00 76.26 C ATOM 856 OD1 ASP A 120 -48.901 15.758 5.578 1.00 75.19 O ATOM 857 OD2 ASP A 120 -48.071 13.936 4.685 1.00 77.31 O ATOM 858 N PRO A 121 -48.062 18.732 5.978 1.00 76.19 N ATOM 859 CA PRO A 121 -48.665 19.489 7.083 1.00 73.77 C ATOM 860 C PRO A 121 -49.105 18.591 8.238 1.00 73.72 C ATOM 861 O PRO A 121 -49.194 19.061 9.374 1.00 73.78 O ATOM 862 CB PRO A 121 -49.877 20.175 6.434 1.00 75.79 C ATOM 863 CG PRO A 121 -50.125 19.432 5.163 1.00 76.61 C ATOM 864 CD PRO A 121 -48.775 18.963 4.707 1.00 76.17 C ATOM 865 N SER A 122 -49.369 17.316 7.939 1.00 73.69 N ATOM 866 CA SER A 122 -49.627 16.291 8.958 1.00 77.68 C ATOM 867 C SER A 122 -48.389 15.992 9.799 1.00 79.08 C ATOM 868 O SER A 122 -48.490 15.840 11.018 1.00 80.50 O ATOM 869 CB SER A 122 -50.116 14.983 8.318 1.00 78.89 C ATOM 870 OG SER A 122 -51.525 14.956 8.186 1.00 81.07 O ATOM 871 N ILE A 123 -47.236 15.888 9.132 1.00 77.66 N ATOM 872 CA ILE A 123 -45.959 15.555 9.775 1.00 73.78 C ATOM 873 C ILE A 123 -45.384 16.741 10.557 1.00 70.40 C ATOM 874 O ILE A 123 -45.046 16.608 11.737 1.00 67.62 O ATOM 875 CB ILE A 123 -44.932 14.998 8.748 1.00 73.51 C ATOM 876 CG1 ILE A 123 -45.014 13.470 8.662 1.00 73.99 C ATOM 877 CG2 ILE A 123 -43.501 15.380 9.107 1.00 71.20 C ATOM 878 CD1 ILE A 123 -46.133 12.936 7.796 1.00 76.07 C ATOM 879 N GLY A 124 -45.298 17.894 9.896 1.00 66.90 N ATOM 880 CA GLY A 124 -44.668 19.076 10.467 1.00 62.72 C ATOM 881 C GLY A 124 -43.209 19.198 10.074 1.00 62.02 C ATOM 882 O GLY A 124 -42.799 18.733 9.006 1.00 64.89 O ATOM 883 N ILE A 125 -42.426 19.820 10.954 1.00 59.18 N ATOM 884 CA ILE A 125 -41.006 20.092 10.719 1.00 54.74 C ATOM 885 C ILE A 125 -40.154 19.494 11.844 1.00 51.45 C ATOM 886 O ILE A 125 -40.504 19.617 13.014 1.00 50.20 O ATOM 887 CB ILE A 125 -40.758 21.623 10.604 1.00 55.87 C ATOM 888 CG1 ILE A 125 -41.468 22.210 9.373 1.00 56.25 C ATOM 889 CG2 ILE A 125 -39.275 21.960 10.571 1.00 56.46 C ATOM 890 CD1 ILE A 125 -41.021 21.638 8.044 1.00 56.43 C ATOM 891 N TYR A 126 -39.042 18.846 11.490 1.00 48.67 N ATOM 892 CA TYR A 126 -38.091 18.345 12.488 1.00 45.89 C ATOM 893 C TYR A 126 -36.708 18.981 12.360 1.00 45.79 C ATOM 894 O TYR A 126 -36.200 19.171 11.247 1.00 45.60 O ATOM 895 CB TYR A 126 -37.950 16.822 12.411 1.00 43.04 C ATOM 896 CG TYR A 126 -39.196 16.053 12.784 1.00 43.00 C ATOM 897 CD1 TYR A 126 -39.489 15.753 14.117 1.00 42.80 C ATOM 898 CD2 TYR A 126 -40.077 15.606 11.800 1.00 41.79 C ATOM 899 CE1 TYR A 126 -40.629 15.039 14.458 1.00 43.61 C ATOM 900 CE2 TYR A 126 -41.220 14.893 12.127 1.00 42.00 C ATOM 901 CZ TYR A 126 -41.496 14.614 13.455 1.00 44.88 C ATOM 902 OH TYR A 126 -42.635 13.910 13.770 1.00 46.99 O ATOM 903 N GLY A 127 -36.110 19.319 13.505 1.00 42.43 N ATOM 904 CA GLY A 127 -34.686 19.640 13.577 1.00 39.47 C ATOM 905 C GLY A 127 -33.928 18.321 13.532 1.00 39.74 C ATOM 906 O GLY A 127 -34.471 17.284 13.908 1.00 41.96 O ATOM 907 N LEU A 128 -32.685 18.345 13.063 1.00 38.60 N ATOM 908 CA LEU A 128 -31.887 17.130 12.975 1.00 35.89 C ATOM 909 C LEU A 128 -30.472 17.392 13.456 1.00 36.64 C ATOM 910 O LEU A 128 -29.903 18.447 13.161 1.00 37.55 O ATOM 911 CB LEU A 128 -31.888 16.591 11.544 1.00 35.78 C ATOM 912 CG LEU A 128 -31.266 15.208 11.282 1.00 37.05 C ATOM 913 CD1 LEU A 128 -32.036 14.108 11.981 1.00 34.94 C ATOM 914 CD2 LEU A 128 -31.175 14.900 9.791 1.00 36.34 C ATOM 915 N ASP A 129 -29.931 16.437 14.218 1.00 36.26 N ATOM 916 CA ASP A 129 -28.567 16.484 14.737 1.00 36.13 C ATOM 917 C ASP A 129 -27.683 15.505 13.988 1.00 34.58 C ATOM 918 O ASP A 129 -28.067 14.359 13.776 1.00 33.21 O ATOM 919 CB ASP A 129 -28.530 16.070 16.220 1.00 38.05 C ATOM 920 CG ASP A 129 -29.149 17.101 17.150 1.00 41.06 C ATOM 921 OD1 ASP A 129 -28.873 18.312 16.994 1.00 41.86 O ATOM 922 OD2 ASP A 129 -29.906 16.687 18.059 1.00 44.09 O ATOM 923 N PHE A 130 -26.480 15.943 13.641 1.00 33.32 N ATOM 924 CA PHE A 130 -25.493 15.087 13.000 1.00 34.91 C ATOM 925 C PHE A 130 -24.298 14.994 13.935 1.00 37.38 C ATOM 926 O PHE A 130 -23.866 16.013 14.494 1.00 40.84 O ATOM 927 CB PHE A 130 -24.986 15.710 11.681 1.00 35.86 C ATOM 928 CG PHE A 130 -26.030 15.869 10.599 1.00 35.64 C ATOM 929 CD1 PHE A 130 -27.085 16.769 10.738 1.00 35.74 C ATOM 930 CD2 PHE A 130 -25.911 15.165 9.396 1.00 37.15 C ATOM 931 CE1 PHE A 130 -28.022 16.934 9.722 1.00 36.09 C ATOM 932 CE2 PHE A 130 -26.847 15.321 8.377 1.00 36.08 C ATOM 933 CZ PHE A 130 -27.903 16.208 8.541 1.00 36.25 C ATOM 934 N TYR A 131 -23.748 13.794 14.103 1.00 37.92 N ATOM 935 CA TYR A 131 -22.408 13.663 14.693 1.00 37.56 C ATOM 936 C TYR A 131 -21.544 12.698 13.885 1.00 38.03 C ATOM 937 O TYR A 131 -21.950 11.570 13.586 1.00 39.57 O ATOM 938 CB TYR A 131 -22.455 13.286 16.182 1.00 36.51 C ATOM 939 CG TYR A 131 -21.192 13.644 16.949 1.00 35.86 C ATOM 940 CD1 TYR A 131 -20.241 12.666 17.247 1.00 35.32 C ATOM 941 CD2 TYR A 131 -20.923 14.975 17.342 1.00 36.43 C ATOM 942 CE1 TYR A 131 -19.078 12.981 17.930 1.00 34.39 C ATOM 943 CE2 TYR A 131 -19.753 15.303 18.030 1.00 33.75 C ATOM 944 CZ TYR A 131 -18.838 14.294 18.322 1.00 35.34 C ATOM 945 OH TYR A 131 -17.670 14.569 19.006 1.00 35.36 O ATOM 946 N VAL A 132 -20.356 13.169 13.517 1.00 38.34 N ATOM 947 CA VAL A 132 -19.466 12.421 12.649 1.00 40.08 C ATOM 948 C VAL A 132 -18.247 11.989 13.425 1.00 41.90 C ATOM 949 O VAL A 132 -17.464 12.835 13.876 1.00 41.42 O ATOM 950 CB VAL A 132 -18.956 13.283 11.474 1.00 39.93 C ATOM 951 CG1 VAL A 132 -18.131 12.435 10.518 1.00 39.31 C ATOM 952 CG2 VAL A 132 -20.109 13.962 10.755 1.00 39.93 C ATOM 953 N VAL A 133 -18.071 10.678 13.565 1.00 43.73 N ATOM 954 CA VAL A 133 -16.836 10.161 14.147 1.00 46.21 C ATOM 955 C VAL A 133 -15.873 9.645 13.077 1.00 47.98 C ATOM 956 O VAL A 133 -16.194 8.769 12.264 1.00 52.47 O ATOM 957 CB VAL A 133 -17.052 9.228 15.392 1.00 47.85 C ATOM 958 CG1 VAL A 133 -18.513 8.848 15.587 1.00 46.48 C ATOM 959 CG2 VAL A 133 -16.120 8.025 15.398 1.00 46.38 C ATOM 960 N LEU A 134 -14.699 10.259 13.071 1.00 49.43 N ATOM 961 CA LEU A 134 -13.648 9.965 12.111 1.00 50.65 C ATOM 962 C LEU A 134 -12.726 8.846 12.589 1.00 52.07 C ATOM 963 O LEU A 134 -12.730 8.488 13.767 1.00 53.37 O ATOM 964 CB LEU A 134 -12.852 11.235 11.828 1.00 49.45 C ATOM 965 CG LEU A 134 -13.180 12.132 10.621 1.00 48.97 C ATOM 966 CD1 LEU A 134 -14.500 11.828 9.916 1.00 45.05 C ATOM 967 CD2 LEU A 134 -13.090 13.583 11.051 1.00 46.64 C ATOM 968 N GLY A 135 -11.959 8.284 11.661 1.00 54.23 N ATOM 969 CA GLY A 135 -11.006 7.225 11.976 1.00 59.34 C ATOM 970 C GLY A 135 -9.937 7.116 10.909 1.00 64.64 C ATOM 971 O GLY A 135 -9.962 7.848 9.912 1.00 60.82 O ATOM 972 N ARG A 136 -8.993 6.204 11.123 1.00 73.67 N ATOM 973 CA ARG A 136 -7.962 5.903 10.132 1.00 79.41 C ATOM 974 C ARG A 136 -8.164 4.495 9.573 1.00 86.74 C ATOM 975 O ARG A 136 -8.499 3.578 10.328 1.00 85.47 O ATOM 976 CB ARG A 136 -6.570 6.058 10.738 1.00 78.31 C ATOM 977 CG ARG A 136 -6.283 7.458 11.245 1.00 75.19 C ATOM 978 CD ARG A 136 -4.803 7.639 11.519 1.00 72.73 C ATOM 979 NE ARG A 136 -4.556 8.675 12.518 1.00 70.50 N ATOM 980 CZ ARG A 136 -4.414 9.969 12.246 1.00 70.76 C ATOM 981 NH1 ARG A 136 -4.499 10.405 10.996 1.00 69.02 N ATOM 982 NH2 ARG A 136 -4.186 10.832 13.229 1.00 72.45 N ATOM 983 N PRO A 137 -7.964 4.321 8.248 1.00 97.42 N ATOM 984 CA PRO A 137 -8.307 3.086 7.517 1.00102.84 C ATOM 985 C PRO A 137 -7.573 1.805 7.954 1.00107.89 C ATOM 986 O PRO A 137 -7.753 0.757 7.326 1.00111.66 O ATOM 987 CB PRO A 137 -7.962 3.433 6.059 1.00103.83 C ATOM 988 CG PRO A 137 -7.995 4.924 6.000 1.00104.06 C ATOM 989 CD PRO A 137 -7.457 5.360 7.333 1.00101.28 C ATOM 990 N GLY A 138 -6.774 1.884 9.018 1.00108.53 N ATOM 991 CA GLY A 138 -6.079 0.714 9.557 1.00109.31 C ATOM 992 C GLY A 138 -6.994 -0.258 10.288 1.00113.00 C ATOM 993 O GLY A 138 -8.189 -0.365 9.990 1.00111.91 O ATOM 994 N LYS A 154 -3.912 3.453 15.501 1.00107.41 N ATOM 995 CA LYS A 154 -4.562 3.939 16.716 1.00106.76 C ATOM 996 C LYS A 154 -4.052 5.325 17.137 1.00103.99 C ATOM 997 O LYS A 154 -4.458 5.846 18.183 1.00 98.25 O ATOM 998 CB LYS A 154 -4.402 2.929 17.850 1.00101.91 C ATOM 999 N HIS A 155 -3.170 5.912 16.321 1.00102.13 N ATOM 1000 CA HIS A 155 -2.663 7.273 16.547 1.00 99.66 C ATOM 1001 C HIS A 155 -3.821 8.285 16.562 1.00 97.27 C ATOM 1002 O HIS A 155 -4.648 8.306 15.638 1.00 97.48 O ATOM 1003 CB HIS A 155 -1.619 7.646 15.495 1.00 92.21 C ATOM 1004 N ARG A 156 -3.881 9.099 17.620 1.00 87.53 N ATOM 1005 CA ARG A 156 -4.993 10.037 17.844 1.00 81.22 C ATOM 1006 C ARG A 156 -5.199 11.035 16.696 1.00 77.78 C ATOM 1007 O ARG A 156 -4.239 11.485 16.058 1.00 79.79 O ATOM 1008 CB ARG A 156 -4.812 10.790 19.168 1.00 75.78 C ATOM 1009 N ILE A 157 -6.462 11.354 16.426 1.00 68.72 N ATOM 1010 CA ILE A 157 -6.808 12.404 15.474 1.00 63.48 C ATOM 1011 C ILE A 157 -7.022 13.682 16.277 1.00 57.69 C ATOM 1012 O ILE A 157 -7.895 13.731 17.135 1.00 59.55 O ATOM 1013 CB ILE A 157 -8.079 12.053 14.657 1.00 59.59 C ATOM 1014 CG1 ILE A 157 -7.918 10.697 13.961 1.00 58.67 C ATOM 1015 CG2 ILE A 157 -8.385 13.144 13.642 1.00 56.25 C ATOM 1016 CD1 ILE A 157 -9.221 9.955 13.741 1.00 58.86 C ATOM 1017 N SER A 158 -6.210 14.700 16.014 1.00 56.89 N ATOM 1018 CA SER A 158 -6.341 15.983 16.709 1.00 56.33 C ATOM 1019 C SER A 158 -7.523 16.782 16.163 1.00 55.62 C ATOM 1020 O SER A 158 -8.057 16.461 15.100 1.00 55.40 O ATOM 1021 CB SER A 158 -5.040 16.794 16.620 1.00 54.19 C ATOM 1022 OG SER A 158 -4.743 17.177 15.289 1.00 54.32 O ATOM 1023 N LYS A 159 -7.930 17.812 16.899 1.00 56.31 N ATOM 1024 CA LYS A 159 -9.001 18.711 16.474 1.00 57.07 C ATOM 1025 C LYS A 159 -8.631 19.401 15.158 1.00 59.98 C ATOM 1026 O LYS A 159 -9.499 19.657 14.321 1.00 62.62 O ATOM 1027 CB LYS A 159 -9.253 19.757 17.555 1.00 57.76 C ATOM 1028 CG LYS A 159 -10.492 20.617 17.368 1.00 59.71 C ATOM 1029 CD LYS A 159 -10.402 21.829 18.280 1.00 62.29 C ATOM 1030 CE LYS A 159 -11.738 22.526 18.471 1.00 66.81 C ATOM 1031 NZ LYS A 159 -12.358 22.188 19.783 1.00 67.99 N ATOM 1032 N GLU A 160 -7.338 19.679 14.982 1.00 59.39 N ATOM 1033 CA GLU A 160 -6.831 20.411 13.816 1.00 59.46 C ATOM 1034 C GLU A 160 -6.778 19.561 12.552 1.00 55.10 C ATOM 1035 O GLU A 160 -7.015 20.076 11.466 1.00 52.88 O ATOM 1036 CB GLU A 160 -5.456 21.027 14.100 1.00 62.61 C ATOM 1037 CG GLU A 160 -5.472 22.152 15.127 1.00 69.89 C ATOM 1038 CD GLU A 160 -5.702 21.670 16.559 1.00 78.44 C ATOM 1039 OE1 GLU A 160 -5.356 20.507 16.880 1.00 82.52 O ATOM 1040 OE2 GLU A 160 -6.233 22.462 17.375 1.00 84.84 O ATOM 1041 N GLU A 161 -6.469 18.272 12.696 1.00 53.71 N ATOM 1042 CA GLU A 161 -6.486 17.342 11.565 1.00 53.49 C ATOM 1043 C GLU A 161 -7.897 17.195 11.003 1.00 50.66 C ATOM 1044 O GLU A 161 -8.093 17.295 9.799 1.00 49.16 O ATOM 1045 CB GLU A 161 -5.935 15.970 11.954 1.00 57.19 C ATOM 1046 CG GLU A 161 -4.451 15.963 12.290 1.00 65.44 C ATOM 1047 CD GLU A 161 -3.960 14.590 12.722 1.00 68.45 C ATOM 1048 OE1 GLU A 161 -4.190 14.198 13.891 1.00 68.02 O ATOM 1049 OE2 GLU A 161 -3.337 13.902 11.886 1.00 70.10 O ATOM 1050 N ALA A 162 -8.874 16.963 11.880 1.00 49.05 N ATOM 1051 CA ALA A 162 -10.273 16.859 11.478 1.00 47.38 C ATOM 1052 C ALA A 162 -10.742 18.139 10.799 1.00 48.08 C ATOM 1053 O ALA A 162 -11.558 18.092 9.875 1.00 49.04 O ATOM 1054 CB ALA A 162 -11.159 16.541 12.674 1.00 45.48 C ATOM 1055 N MET A 163 -10.215 19.274 11.254 1.00 46.50 N ATOM 1056 CA MET A 163 -10.565 20.562 10.678 1.00 48.05 C ATOM 1057 C MET A 163 -10.048 20.730 9.250 1.00 47.29 C ATOM 1058 O MET A 163 -10.796 21.168 8.370 1.00 42.95 O ATOM 1059 CB MET A 163 -10.114 21.713 11.580 1.00 47.94 C ATOM 1060 CG MET A 163 -11.073 21.978 12.734 1.00 48.10 C ATOM 1061 SD MET A 163 -10.404 23.185 13.889 1.00 53.70 S ATOM 1062 CE MET A 163 -10.715 24.722 13.035 1.00 51.96 C ATOM 1063 N ARG A 164 -8.789 20.366 9.011 1.00 48.61 N ATOM 1064 CA ARG A 164 -8.259 20.458 7.653 1.00 53.28 C ATOM 1065 C ARG A 164 -8.727 19.327 6.739 1.00 51.16 C ATOM 1066 O ARG A 164 -8.739 19.478 5.526 1.00 55.98 O ATOM 1067 CB ARG A 164 -6.740 20.715 7.607 1.00 62.25 C ATOM 1068 CG ARG A 164 -5.815 19.598 8.058 1.00 71.65 C ATOM 1069 CD ARG A 164 -4.371 20.047 7.843 1.00 81.97 C ATOM 1070 NE ARG A 164 -3.377 19.059 8.273 1.00 88.95 N ATOM 1071 CZ ARG A 164 -2.771 19.052 9.461 1.00 94.48 C ATOM 1072 NH1 ARG A 164 -3.047 19.979 10.378 1.00 94.49 N ATOM 1073 NH2 ARG A 164 -1.881 18.107 9.735 1.00 97.25 N ATOM 1074 N TRP A 165 -9.147 18.210 7.326 1.00 48.28 N ATOM 1075 CA TRP A 165 -9.847 17.164 6.582 1.00 47.64 C ATOM 1076 C TRP A 165 -11.157 17.686 6.042 1.00 47.28 C ATOM 1077 O TRP A 165 -11.461 17.529 4.858 1.00 45.42 O ATOM 1078 CB TRP A 165 -10.080 15.946 7.464 1.00 45.42 C ATOM 1079 CG TRP A 165 -10.847 14.823 6.802 1.00 45.64 C ATOM 1080 CD1 TRP A 165 -10.323 13.732 6.103 1.00 46.30 C ATOM 1081 CD2 TRP A 165 -12.309 14.624 6.775 1.00 43.73 C ATOM 1082 NE1 TRP A 165 -11.325 12.901 5.662 1.00 44.63 N ATOM 1083 CE2 TRP A 165 -12.540 13.374 6.030 1.00 44.76 C ATOM 1084 CE3 TRP A 165 -13.403 15.318 7.279 1.00 42.31 C ATOM 1085 CZ2 TRP A 165 -13.817 12.875 5.808 1.00 43.48 C ATOM 1086 CZ3 TRP A 165 -14.691 14.804 7.045 1.00 42.06 C ATOM 1087 CH2 TRP A 165 -14.890 13.616 6.325 1.00 42.01 C ATOM 1088 N PHE A 166 -11.943 18.321 6.907 1.00 45.75 N ATOM 1089 CA PHE A 166 -13.223 18.884 6.505 1.00 42.90 C ATOM 1090 C PHE A 166 -13.016 19.979 5.465 1.00 43.14 C ATOM 1091 O PHE A 166 -13.785 20.099 4.512 1.00 45.40 O ATOM 1092 CB PHE A 166 -13.957 19.423 7.734 1.00 40.17 C ATOM 1093 CG PHE A 166 -15.120 20.314 7.410 1.00 38.74 C ATOM 1094 CD1 PHE A 166 -16.356 19.779 7.114 1.00 37.76 C ATOM 1095 CD2 PHE A 166 -14.974 21.697 7.403 1.00 39.27 C ATOM 1096 CE1 PHE A 166 -17.431 20.600 6.808 1.00 39.50 C ATOM 1097 CE2 PHE A 166 -16.049 22.528 7.101 1.00 40.64 C ATOM 1098 CZ PHE A 166 -17.279 21.980 6.803 1.00 37.77 C ATOM 1099 N GLN A 167 -11.970 20.771 5.646 1.00 43.87 N ATOM 1100 CA GLN A 167 -11.724 21.915 4.780 1.00 47.29 C ATOM 1101 C GLN A 167 -11.321 21.499 3.375 1.00 49.92 C ATOM 1102 O GLN A 167 -11.740 22.110 2.394 1.00 51.86 O ATOM 1103 CB GLN A 167 -10.649 22.803 5.382 1.00 43.80 C ATOM 1104 CG GLN A 167 -11.149 23.628 6.548 1.00 42.90 C ATOM 1105 CD GLN A 167 -10.015 24.246 7.339 1.00 44.76 C ATOM 1106 OE1 GLN A 167 -8.903 23.704 7.398 1.00 44.45 O ATOM 1107 NE2 GLN A 167 -10.286 25.394 7.948 1.00 44.21 N ATOM 1108 N GLN A 168 -10.503 20.457 3.297 1.00 52.32 N ATOM 1109 CA GLN A 168 -10.011 19.940 2.036 1.00 55.54 C ATOM 1110 C GLN A 168 -11.011 19.037 1.320 1.00 56.28 C ATOM 1111 O GLN A 168 -11.217 19.186 0.116 1.00 57.31 O ATOM 1112 CB GLN A 168 -8.705 19.195 2.255 1.00 57.16 C ATOM 1113 CG GLN A 168 -7.536 20.119 2.548 1.00 63.56 C ATOM 1114 CD GLN A 168 -6.230 19.369 2.734 1.00 65.30 C ATOM 1115 OE1 GLN A 168 -6.124 18.182 2.410 1.00 66.17 O ATOM 1116 NE2 GLN A 168 -5.225 20.062 3.251 1.00 63.68 N ATOM 1117 N LYS A 169 -11.619 18.102 2.047 1.00 52.70 N ATOM 1118 CA LYS A 169 -12.529 17.149 1.421 1.00 56.85 C ATOM 1119 C LYS A 169 -13.851 17.770 0.960 1.00 57.83 C ATOM 1120 O LYS A 169 -14.408 17.339 -0.051 1.00 60.05 O ATOM 1121 CB LYS A 169 -12.789 15.915 2.297 1.00 56.94 C ATOM 1122 CG LYS A 169 -13.530 14.829 1.526 1.00 62.37 C ATOM 1123 CD LYS A 169 -13.698 13.524 2.285 1.00 66.36 C ATOM 1124 CE LYS A 169 -14.600 12.582 1.496 1.00 69.78 C ATOM 1125 NZ LYS A 169 -14.895 11.318 2.233 1.00 70.67 N ATOM 1126 N TYR A 170 -14.349 18.774 1.682 1.00 54.07 N ATOM 1127 CA TYR A 170 -15.615 19.406 1.299 1.00 52.78 C ATOM 1128 C TYR A 170 -15.481 20.852 0.851 1.00 50.56 C ATOM 1129 O TYR A 170 -16.492 21.518 0.610 1.00 50.36 O ATOM 1130 CB TYR A 170 -16.657 19.266 2.417 1.00 54.35 C ATOM 1131 CG TYR A 170 -16.977 17.823 2.695 1.00 56.56 C ATOM 1132 CD1 TYR A 170 -17.708 17.070 1.779 1.00 58.82 C ATOM 1133 CD2 TYR A 170 -16.521 17.194 3.851 1.00 56.20 C ATOM 1134 CE1 TYR A 170 -17.988 15.732 2.008 1.00 60.12 C ATOM 1135 CE2 TYR A 170 -16.802 15.856 4.090 1.00 58.38 C ATOM 1136 CZ TYR A 170 -17.533 15.132 3.163 1.00 57.45 C ATOM 1137 OH TYR A 170 -17.821 13.808 3.376 1.00 60.97 O ATOM 1138 N ASP A 171 -14.238 21.322 0.711 1.00 51.56 N ATOM 1139 CA ASP A 171 -13.944 22.752 0.516 1.00 50.90 C ATOM 1140 C ASP A 171 -14.721 23.563 1.565 1.00 50.11 C ATOM 1141 O ASP A 171 -15.265 24.635 1.286 1.00 49.58 O ATOM 1142 CB ASP A 171 -14.250 23.204 -0.926 1.00 52.15 C ATOM 1143 CG ASP A 171 -13.498 24.482 -1.319 1.00 57.42 C ATOM 1144 OD1 ASP A 171 -12.257 24.526 -1.159 1.00 57.10 O ATOM 1145 OD2 ASP A 171 -14.148 25.444 -1.794 1.00 56.79 O ATOM 1146 N GLY A 172 -14.768 23.017 2.779 1.00 50.76 N ATOM 1147 CA GLY A 172 -15.601 23.554 3.847 1.00 49.10 C ATOM 1148 C GLY A 172 -15.013 24.772 4.532 1.00 47.90 C ATOM 1149 O GLY A 172 -13.796 24.996 4.499 1.00 45.96 O ATOM 1150 N ILE A 173 -15.890 25.550 5.158 1.00 44.32 N ATOM 1151 CA ILE A 173 -15.503 26.762 5.871 1.00 44.95 C ATOM 1152 C ILE A 173 -15.774 26.608 7.372 1.00 45.02 C ATOM 1153 O ILE A 173 -16.894 26.304 7.790 1.00 42.23 O ATOM 1154 CB ILE A 173 -16.252 27.990 5.307 1.00 44.30 C ATOM 1155 CG1 ILE A 173 -15.758 28.298 3.887 1.00 44.87 C ATOM 1156 CG2 ILE A 173 -16.106 29.203 6.227 1.00 42.29 C ATOM 1157 CD1 ILE A 173 -16.665 29.219 3.095 1.00 43.65 C ATOM 1158 N ILE A 174 -14.730 26.809 8.165 1.00 44.76 N ATOM 1159 CA ILE A 174 -14.830 26.742 9.617 1.00 43.91 C ATOM 1160 C ILE A 174 -14.657 28.145 10.179 1.00 45.78 C ATOM 1161 O ILE A 174 -13.544 28.682 10.249 1.00 48.87 O ATOM 1162 CB ILE A 174 -13.795 25.770 10.214 1.00 43.34 C ATOM 1163 CG1 ILE A 174 -14.109 24.341 9.776 1.00 42.55 C ATOM 1164 CG2 ILE A 174 -13.781 25.848 11.732 1.00 44.49 C ATOM 1165 CD1 ILE A 174 -12.937 23.398 9.898 1.00 41.30 C ATOM 1166 N LEU A 175 -15.785 28.740 10.544 1.00 45.30 N ATOM 1167 CA LEU A 175 -15.832 30.055 11.159 1.00 46.34 C ATOM 1168 C LEU A 175 -15.119 30.032 12.499 1.00 47.99 C ATOM 1169 O LEU A 175 -15.046 28.976 13.142 1.00 47.58 O ATOM 1170 CB LEU A 175 -17.290 30.464 11.376 1.00 45.06 C ATOM 1171 CG LEU A 175 -17.952 31.392 10.360 1.00 46.75 C ATOM 1172 CD1 LEU A 175 -17.332 31.321 8.973 1.00 45.38 C ATOM 1173 CD2 LEU A 175 -19.458 31.147 10.312 1.00 48.01 C ATOM 1174 N PRO A 176 -14.604 31.199 12.932 1.00 50.71 N ATOM 1175 CA PRO A 176 -13.953 31.300 14.242 1.00 52.06 C ATOM 1176 C PRO A 176 -14.880 30.876 15.374 1.00 52.64 C ATOM 1177 O PRO A 176 -16.104 31.058 15.291 1.00 50.40 O ATOM 1178 CB PRO A 176 -13.630 32.793 14.363 1.00 50.09 C ATOM 1179 CG PRO A 176 -13.533 33.272 12.952 1.00 51.59 C ATOM 1180 CD PRO A 176 -14.565 32.483 12.202 1.00 49.84 C ATOM 1181 N GLY A 177 -14.281 30.306 16.416 1.00 54.98 N ATOM 1182 CA GLY A 177 -14.992 29.978 17.640 1.00 56.50 C ATOM 1183 C GLY A 177 -15.738 31.166 18.217 1.00 59.97 C ATOM 1184 O GLY A 177 -15.219 32.292 18.259 1.00 62.80 O ATOM 1185 N LYS A 178 -16.979 30.916 18.622 1.00 61.46 N ATOM 1186 CA LYS A 178 -17.765 31.883 19.383 1.00 61.13 C ATOM 1187 C LYS A 178 -17.823 31.449 20.851 1.00 61.67 C ATOM 1188 O LYS A 178 -17.393 30.344 21.211 1.00 58.07 O ATOM 1189 CB LYS A 178 -19.176 32.027 18.803 1.00 60.04 C ATOM 1190 CG LYS A 178 -19.318 33.072 17.707 1.00 58.71 C ATOM 1191 CD LYS A 178 -20.773 33.212 17.293 1.00 59.21 C ATOM 1192 CE LYS A 178 -20.995 34.473 16.475 1.00 64.06 C ATOM 1193 NZ LYS A 178 -22.446 34.784 16.335 1.00 65.08 N ATOM 1194 OXT LYS A 178 -18.291 32.198 21.716 1.00 62.94 O TER 1195 LYS A 178 ATOM 1196 N GLU B 293 -20.819 3.547 27.643 1.00 79.76 N ATOM 1197 CA GLU B 293 -22.060 3.238 26.869 1.00 78.20 C ATOM 1198 C GLU B 293 -21.789 3.008 25.373 1.00 79.58 C ATOM 1199 O GLU B 293 -22.425 2.148 24.757 1.00 76.93 O ATOM 1200 CB GLU B 293 -23.108 4.343 27.066 1.00 77.97 C ATOM 1201 N ASP B 294 -20.854 3.775 24.801 1.00 82.53 N ATOM 1202 CA ASP B 294 -20.469 3.660 23.374 1.00 79.73 C ATOM 1203 C ASP B 294 -18.946 3.679 23.213 1.00 76.03 C ATOM 1204 O ASP B 294 -18.308 4.687 23.506 1.00 80.98 O ATOM 1205 CB ASP B 294 -21.119 4.777 22.535 1.00 78.99 C ATOM 1206 CG ASP B 294 -20.714 4.751 21.039 1.00 81.61 C ATOM 1207 OD1 ASP B 294 -19.812 3.987 20.624 1.00 76.69 O ATOM 1208 OD2 ASP B 294 -21.314 5.531 20.263 1.00 81.59 O ATOM 1209 N PRO B 295 -18.367 2.563 22.726 1.00 73.94 N ATOM 1210 CA PRO B 295 -16.912 2.371 22.619 1.00 71.22 C ATOM 1211 C PRO B 295 -16.213 3.155 21.502 1.00 67.56 C ATOM 1212 O PRO B 295 -14.988 3.142 21.431 1.00 68.32 O ATOM 1213 CB PRO B 295 -16.784 0.869 22.347 1.00 70.49 C ATOM 1214 CG PRO B 295 -18.042 0.530 21.625 1.00 71.45 C ATOM 1215 CD PRO B 295 -19.107 1.367 22.274 1.00 70.28 C ATOM 1216 N GLU B 296 -16.971 3.816 20.633 1.00 67.71 N ATOM 1217 CA GLU B 296 -16.375 4.571 19.520 1.00 64.01 C ATOM 1218 C GLU B 296 -16.189 6.067 19.813 1.00 62.39 C ATOM 1219 O GLU B 296 -15.638 6.806 18.991 1.00 62.22 O ATOM 1220 CB GLU B 296 -17.181 4.365 18.240 1.00 61.00 C ATOM 1221 CG GLU B 296 -16.843 3.076 17.518 1.00 60.72 C ATOM 1222 CD GLU B 296 -17.739 2.818 16.323 1.00 61.90 C ATOM 1223 OE1 GLU B 296 -18.972 2.691 16.503 1.00 61.30 O ATOM 1224 OE2 GLU B 296 -17.205 2.718 15.201 1.00 61.67 O ATOM 1225 N ILE B 297 -16.655 6.500 20.983 1.00 60.58 N ATOM 1226 CA ILE B 297 -16.469 7.877 21.444 1.00 62.03 C ATOM 1227 C ILE B 297 -15.888 7.898 22.857 1.00 65.19 C ATOM 1228 O ILE B 297 -15.919 6.888 23.561 1.00 67.95 O ATOM 1229 CB ILE B 297 -17.781 8.711 21.400 1.00 57.52 C ATOM 1230 CG1 ILE B 297 -18.895 8.029 22.203 1.00 53.00 C ATOM 1231 CG2 ILE B 297 -18.199 8.979 19.954 1.00 54.54 C ATOM 1232 CD1 ILE B 297 -19.982 8.971 22.672 1.00 55.16 C ATOM 1233 N SER B 298 -15.359 9.048 23.263 1.00 64.46 N ATOM 1234 CA SER B 298 -14.824 9.208 24.607 1.00 66.09 C ATOM 1235 C SER B 298 -15.533 10.346 25.332 1.00 65.28 C ATOM 1236 O SER B 298 -16.478 10.938 24.808 1.00 65.41 O ATOM 1237 CB SER B 298 -13.306 9.444 24.560 1.00 67.51 C ATOM 1238 OG SER B 298 -12.989 10.607 23.813 1.00 70.54 O ATOM 1239 N LEU B 299 -15.079 10.642 26.544 1.00 63.98 N ATOM 1240 CA LEU B 299 -15.627 11.747 27.308 1.00 63.71 C ATOM 1241 C LEU B 299 -15.277 13.076 26.654 1.00 61.31 C ATOM 1242 O LEU B 299 -15.957 14.074 26.879 1.00 61.50 O ATOM 1243 CB LEU B 299 -15.153 11.701 28.770 1.00 66.40 C ATOM 1244 CG LEU B 299 -16.105 11.205 29.878 1.00 68.94 C ATOM 1245 CD1 LEU B 299 -17.016 12.329 30.373 1.00 68.61 C ATOM 1246 CD2 LEU B 299 -16.914 9.973 29.478 1.00 67.63 C ATOM 1247 N ALA B 300 -14.226 13.071 25.833 1.00 58.38 N ATOM 1248 CA ALA B 300 -13.776 14.267 25.120 1.00 54.43 C ATOM 1249 C ALA B 300 -14.743 14.676 24.004 1.00 51.66 C ATOM 1250 O ALA B 300 -14.637 15.772 23.454 1.00 51.64 O ATOM 1251 CB ALA B 300 -12.374 14.051 24.569 1.00 55.78 C ATOM 1252 N ASP B 301 -15.675 13.782 23.676 1.00 49.64 N ATOM 1253 CA ASP B 301 -16.762 14.067 22.747 1.00 48.65 C ATOM 1254 C ASP B 301 -17.946 14.732 23.468 1.00 46.07 C ATOM 1255 O ASP B 301 -18.873 15.230 22.830 1.00 46.20 O ATOM 1256 CB ASP B 301 -17.214 12.780 22.037 1.00 49.51 C ATOM 1257 CG ASP B 301 -16.231 12.321 20.954 1.00 54.83 C ATOM 1258 OD1 ASP B 301 -15.710 11.187 21.050 1.00 54.90 O ATOM 1259 OD2 ASP B 301 -15.979 13.088 19.999 1.00 52.73 O ATOM 1260 N TYR B 302 -17.910 14.728 24.795 1.00 43.83 N ATOM 1261 CA TYR B 302 -18.964 15.334 25.617 1.00 45.25 C ATOM 1262 C TYR B 302 -18.826 16.844 25.664 1.00 46.16 C ATOM 1263 O TYR B 302 -17.711 17.377 25.593 1.00 45.03 O ATOM 1264 CB TYR B 302 -18.956 14.761 27.043 1.00 44.17 C ATOM 1265 CG TYR B 302 -19.531 13.361 27.135 1.00 45.10 C ATOM 1266 CD1 TYR B 302 -19.030 12.335 26.345 1.00 42.74 C ATOM 1267 CD2 TYR B 302 -20.576 13.063 28.019 1.00 46.68 C ATOM 1268 CE1 TYR B 302 -19.549 11.061 26.417 1.00 44.18 C ATOM 1269 CE2 TYR B 302 -21.110 11.780 28.091 1.00 45.31 C ATOM 1270 CZ TYR B 302 -20.585 10.786 27.286 1.00 44.98 C ATOM 1271 OH TYR B 302 -21.084 9.505 27.327 1.00 46.80 O ATOM 1272 N TRP B 303 -19.970 17.519 25.772 1.00 43.63 N ATOM 1273 CA TRP B 303 -20.019 18.969 25.855 1.00 42.76 C ATOM 1274 C TRP B 303 -20.627 19.407 27.157 1.00 45.73 C ATOM 1275 O TRP B 303 -21.564 18.784 27.668 1.00 42.85 O ATOM 1276 CB TRP B 303 -20.774 19.563 24.666 1.00 40.22 C ATOM 1277 CG TRP B 303 -22.221 19.127 24.554 1.00 38.37 C ATOM 1278 CD1 TRP B 303 -22.714 17.944 24.010 1.00 36.74 C ATOM 1279 CD2 TRP B 303 -23.416 19.872 24.993 1.00 36.77 C ATOM 1280 NE1 TRP B 303 -24.085 17.909 24.079 1.00 36.79 N ATOM 1281 CE2 TRP B 303 -24.568 19.029 24.663 1.00 36.71 C ATOM 1282 CE3 TRP B 303 -23.632 21.106 25.604 1.00 35.98 C ATOM 1283 CZ2 TRP B 303 -25.875 19.422 24.945 1.00 38.92 C ATOM 1284 CZ3 TRP B 303 -24.950 21.493 25.881 1.00 37.56 C ATOM 1285 CH2 TRP B 303 -26.045 20.674 25.554 1.00 37.77 C ATOM 1286 N LYS B 304 -20.093 20.496 27.697 1.00 47.84 N ATOM 1287 CA LYS B 304 -20.485 20.978 29.003 1.00 50.33 C ATOM 1288 C LYS B 304 -21.547 22.054 28.861 1.00 45.88 C ATOM 1289 O LYS B 304 -21.268 23.119 28.327 1.00 47.02 O ATOM 1290 CB LYS B 304 -19.250 21.533 29.731 1.00 55.41 C ATOM 1291 CG LYS B 304 -19.457 21.872 31.207 1.00 60.84 C ATOM 1292 CD LYS B 304 -18.144 22.303 31.859 1.00 62.73 C ATOM 1293 CE LYS B 304 -18.209 22.186 33.374 1.00 67.88 C ATOM 1294 NZ LYS B 304 -16.908 21.760 33.969 1.00 69.43 N ATOM 1295 N CYS B 305 -22.755 21.775 29.348 1.00 44.83 N ATOM 1296 CA CYS B 305 -23.810 22.783 29.442 1.00 45.26 C ATOM 1297 C CYS B 305 -23.344 23.974 30.285 1.00 49.18 C ATOM 1298 O CYS B 305 -22.839 23.796 31.396 1.00 47.64 O ATOM 1299 CB CYS B 305 -25.080 22.188 30.051 1.00 44.66 C ATOM 1300 SG CYS B 305 -26.386 23.410 30.342 1.00 44.34 S ATOM 1301 N THR B 306 -23.499 25.182 29.743 1.00 52.20 N ATOM 1302 CA THR B 306 -23.042 26.406 30.418 1.00 52.13 C ATOM 1303 C THR B 306 -24.100 26.983 31.342 1.00 52.09 C ATOM 1304 O THR B 306 -23.889 28.033 31.940 1.00 57.37 O ATOM 1305 CB THR B 306 -22.664 27.523 29.421 1.00 54.98 C ATOM 1306 OG1 THR B 306 -23.793 27.819 28.580 1.00 54.56 O ATOM 1307 CG2 THR B 306 -21.446 27.128 28.569 1.00 55.16 C ATOM 1308 N SER B 307 -25.248 26.322 31.441 1.00 50.00 N ATOM 1309 CA SER B 307 -26.296 26.781 32.349 1.00 46.71 C ATOM 1310 C SER B 307 -26.313 26.017 33.671 1.00 46.54 C ATOM 1311 O SER B 307 -26.745 26.553 34.690 1.00 46.67 O ATOM 1312 CB SER B 307 -27.656 26.689 31.685 1.00 46.86 C ATOM 1313 OG SER B 307 -27.658 27.443 30.496 1.00 52.15 O ATOM 1314 N CYS B 308 -25.843 24.771 33.649 1.00 43.54 N ATOM 1315 CA CYS B 308 -25.966 23.889 34.796 1.00 43.36 C ATOM 1316 C CYS B 308 -24.744 22.982 34.947 1.00 47.06 C ATOM 1317 O CYS B 308 -24.645 22.218 35.919 1.00 49.26 O ATOM 1318 CB CYS B 308 -27.254 23.062 34.702 1.00 40.02 C ATOM 1319 SG CYS B 308 -27.028 21.477 33.874 1.00 40.68 S ATOM 1320 N ASN B 309 -23.824 23.066 33.986 1.00 44.45 N ATOM 1321 CA ASN B 309 -22.537 22.354 34.047 1.00 46.02 C ATOM 1322 C ASN B 309 -22.593 20.840 33.873 1.00 46.05 C ATOM 1323 O ASN B 309 -21.602 20.144 34.105 1.00 45.86 O ATOM 1324 CB ASN B 309 -21.746 22.726 35.314 1.00 49.13 C ATOM 1325 CG ASN B 309 -21.252 24.165 35.292 1.00 51.52 C ATOM 1326 OD1 ASN B 309 -21.080 24.765 34.222 1.00 48.53 O ATOM 1327 ND2 ASN B 309 -21.028 24.730 36.473 1.00 51.03 N ATOM 1328 N GLU B 310 -23.745 20.332 33.456 1.00 44.70 N ATOM 1329 CA GLU B 310 -23.852 18.930 33.104 1.00 45.67 C ATOM 1330 C GLU B 310 -22.981 18.595 31.881 1.00 46.52 C ATOM 1331 O GLU B 310 -22.970 19.319 30.875 1.00 44.19 O ATOM 1332 CB GLU B 310 -25.313 18.567 32.844 1.00 44.64 C ATOM 1333 CG GLU B 310 -25.546 17.137 32.381 1.00 49.12 C ATOM 1334 CD GLU B 310 -25.696 16.138 33.519 1.00 51.11 C ATOM 1335 OE1 GLU B 310 -25.503 16.507 34.702 1.00 52.64 O ATOM 1336 OE2 GLU B 310 -26.019 14.971 33.218 1.00 49.13 O ATOM 1337 N MET B 311 -22.237 17.499 32.000 1.00 48.58 N ATOM 1338 CA MET B 311 -21.574 16.868 30.860 1.00 47.45 C ATOM 1339 C MET B 311 -22.595 16.048 30.072 1.00 45.12 C ATOM 1340 O MET B 311 -23.277 15.178 30.615 1.00 42.53 O ATOM 1341 CB MET B 311 -20.401 15.989 31.326 1.00 50.41 C ATOM 1342 CG MET B 311 -19.211 16.789 31.836 1.00 51.90 C ATOM 1343 SD MET B 311 -18.631 17.941 30.576 1.00 61.86 S ATOM 1344 CE MET B 311 -17.304 18.772 31.453 1.00 63.02 C ATOM 1345 N ASN B 312 -22.700 16.351 28.787 1.00 42.74 N ATOM 1346 CA ASN B 312 -23.694 15.742 27.924 1.00 40.35 C ATOM 1347 C ASN B 312 -23.050 14.981 26.782 1.00 39.87 C ATOM 1348 O ASN B 312 -22.048 15.454 26.235 1.00 40.75 O ATOM 1349 CB ASN B 312 -24.586 16.826 27.361 1.00 37.53 C ATOM 1350 CG ASN B 312 -25.525 17.381 28.389 1.00 37.21 C ATOM 1351 OD1 ASN B 312 -26.568 16.784 28.677 1.00 36.76 O ATOM 1352 ND2 ASN B 312 -25.172 18.541 28.950 1.00 36.27 N ATOM 1353 N PRO B 313 -23.607 13.798 26.421 1.00 39.50 N ATOM 1354 CA PRO B 313 -23.099 13.056 25.235 1.00 40.77 C ATOM 1355 C PRO B 313 -23.173 13.922 23.953 1.00 39.34 C ATOM 1356 O PRO B 313 -23.928 14.893 23.918 1.00 38.07 O ATOM 1357 CB PRO B 313 -24.039 11.833 25.129 1.00 40.30 C ATOM 1358 CG PRO B 313 -24.740 11.732 26.450 1.00 40.82 C ATOM 1359 CD PRO B 313 -24.742 13.110 27.073 1.00 39.15 C ATOM 1360 N PRO B 314 -22.383 13.593 22.915 1.00 39.55 N ATOM 1361 CA PRO B 314 -22.416 14.387 21.686 1.00 40.07 C ATOM 1362 C PRO B 314 -23.840 14.695 21.235 1.00 40.93 C ATOM 1363 O PRO B 314 -24.152 15.848 20.939 1.00 41.33 O ATOM 1364 CB PRO B 314 -21.729 13.478 20.675 1.00 40.56 C ATOM 1365 CG PRO B 314 -20.766 12.703 21.492 1.00 42.12 C ATOM 1366 CD PRO B 314 -21.461 12.450 22.799 1.00 41.14 C ATOM 1367 N LEU B 315 -24.697 13.675 21.213 1.00 42.10 N ATOM 1368 CA LEU B 315 -26.104 13.838 20.850 1.00 43.12 C ATOM 1369 C LEU B 315 -26.988 13.373 22.008 1.00 43.61 C ATOM 1370 O LEU B 315 -26.761 12.286 22.533 1.00 44.29 O ATOM 1371 CB LEU B 315 -26.426 13.040 19.579 1.00 42.36 C ATOM 1372 CG LEU B 315 -25.688 13.357 18.274 1.00 43.02 C ATOM 1373 CD1 LEU B 315 -26.408 12.724 17.092 1.00 39.04 C ATOM 1374 CD2 LEU B 315 -25.532 14.851 18.050 1.00 40.83 C ATOM 1375 N PRO B 316 -28.027 14.156 22.380 1.00 44.41 N ATOM 1376 CA PRO B 316 -28.640 15.327 21.730 1.00 44.00 C ATOM 1377 C PRO B 316 -27.883 16.628 21.959 1.00 46.39 C ATOM 1378 O PRO B 316 -26.929 16.656 22.738 1.00 48.99 O ATOM 1379 CB PRO B 316 -29.998 15.423 22.428 1.00 45.67 C ATOM 1380 CG PRO B 316 -29.703 14.968 23.823 1.00 46.04 C ATOM 1381 CD PRO B 316 -28.667 13.874 23.682 1.00 45.38 C ATOM 1382 N SER B 317 -28.321 17.692 21.284 1.00 46.59 N ATOM 1383 CA SER B 317 -27.699 19.013 21.399 1.00 45.32 C ATOM 1384 C SER B 317 -28.463 19.961 22.339 1.00 44.35 C ATOM 1385 O SER B 317 -28.336 21.188 22.248 1.00 44.65 O ATOM 1386 CB SER B 317 -27.537 19.652 20.019 1.00 45.58 C ATOM 1387 OG SER B 317 -28.807 19.899 19.423 1.00 46.66 O ATOM 1388 N HIS B 318 -29.266 19.396 23.233 1.00 43.44 N ATOM 1389 CA HIS B 318 -29.726 20.146 24.408 1.00 42.96 C ATOM 1390 C HIS B 318 -29.252 19.407 25.623 1.00 41.02 C ATOM 1391 O HIS B 318 -28.986 18.208 25.553 1.00 39.76 O ATOM 1392 CB HIS B 318 -31.234 20.267 24.418 1.00 42.22 C ATOM 1393 CG HIS B 318 -31.926 18.945 24.343 1.00 42.99 C ATOM 1394 ND1 HIS B 318 -31.998 18.112 25.397 1.00 44.31 N ATOM 1395 CD2 HIS B 318 -32.563 18.306 23.284 1.00 42.53 C ATOM 1396 CE1 HIS B 318 -32.661 17.001 25.039 1.00 45.77 C ATOM 1397 NE2 HIS B 318 -33.004 17.121 23.738 1.00 44.94 N ATOM 1398 N CYS B 319 -29.127 20.110 26.744 1.00 41.33 N ATOM 1399 CA CYS B 319 -28.659 19.501 27.988 1.00 40.00 C ATOM 1400 C CYS B 319 -29.687 18.487 28.502 1.00 40.34 C ATOM 1401 O CYS B 319 -30.892 18.756 28.505 1.00 38.46 O ATOM 1402 CB CYS B 319 -28.366 20.590 29.028 1.00 41.13 C ATOM 1403 SG CYS B 319 -27.945 20.019 30.703 1.00 39.34 S ATOM 1404 N ASN B 320 -29.210 17.313 28.907 1.00 41.33 N ATOM 1405 CA ASN B 320 -30.100 16.287 29.457 1.00 43.52 C ATOM 1406 C ASN B 320 -30.623 16.604 30.864 1.00 42.38 C ATOM 1407 O ASN B 320 -31.635 16.040 31.270 1.00 39.72 O ATOM 1408 CB ASN B 320 -29.455 14.898 29.421 1.00 42.55 C ATOM 1409 CG ASN B 320 -29.191 14.416 28.007 1.00 45.06 C ATOM 1410 OD1 ASN B 320 -29.986 13.662 27.434 1.00 46.86 O ATOM 1411 ND2 ASN B 320 -28.072 14.850 27.431 1.00 43.14 N ATOM 1412 N ARG B 321 -29.957 17.518 31.582 1.00 44.18 N ATOM 1413 CA ARG B 321 -30.382 17.911 32.945 1.00 44.54 C ATOM 1414 C ARG B 321 -31.406 19.057 32.923 1.00 42.89 C ATOM 1415 O ARG B 321 -32.452 18.956 33.554 1.00 44.19 O ATOM 1416 CB ARG B 321 -29.183 18.307 33.829 1.00 43.59 C ATOM 1417 CG ARG B 321 -29.238 17.747 35.252 1.00 45.87 C ATOM 1418 CD ARG B 321 -28.749 18.691 36.358 1.00 44.54 C ATOM 1419 NE ARG B 321 -27.461 19.353 36.117 1.00 42.86 N ATOM 1420 CZ ARG B 321 -26.301 19.034 36.697 1.00 47.73 C ATOM 1421 NH1 ARG B 321 -26.220 18.037 37.581 1.00 46.21 N ATOM 1422 NH2 ARG B 321 -25.201 19.719 36.388 1.00 47.85 N ATOM 1423 N CYS B 322 -31.098 20.137 32.199 1.00 42.06 N ATOM 1424 CA CYS B 322 -31.901 21.369 32.234 1.00 40.05 C ATOM 1425 C CYS B 322 -32.565 21.749 30.900 1.00 42.43 C ATOM 1426 O CYS B 322 -33.333 22.713 30.852 1.00 42.24 O ATOM 1427 CB CYS B 322 -31.057 22.541 32.752 1.00 40.61 C ATOM 1428 SG CYS B 322 -29.816 23.202 31.603 1.00 40.82 S ATOM 1429 N TRP B 323 -32.269 20.993 29.832 1.00 41.95 N ATOM 1430 CA TRP B 323 -32.804 21.233 28.483 1.00 41.44 C ATOM 1431 C TRP B 323 -32.282 22.422 27.730 1.00 40.75 C ATOM 1432 O TRP B 323 -32.747 22.684 26.634 1.00 44.20 O ATOM 1433 CB TRP B 323 -34.328 21.273 28.487 1.00 40.95 C ATOM 1434 CG TRP B 323 -34.969 20.160 27.698 1.00 41.83 C ATOM 1435 CD1 TRP B 323 -35.850 20.281 26.627 1.00 41.02 C ATOM 1436 CD2 TRP B 323 -34.790 18.717 27.880 1.00 41.43 C ATOM 1437 NE1 TRP B 323 -36.225 19.053 26.158 1.00 40.90 N ATOM 1438 CE2 TRP B 323 -35.627 18.071 26.861 1.00 43.93 C ATOM 1439 CE3 TRP B 323 -34.057 17.924 28.753 1.00 42.56 C ATOM 1440 CZ2 TRP B 323 -35.713 16.687 26.748 1.00 45.20 C ATOM 1441 CZ3 TRP B 323 -34.147 16.531 28.629 1.00 42.65 C ATOM 1442 CH2 TRP B 323 -34.957 15.928 27.652 1.00 43.57 C ATOM 1443 N ALA B 324 -31.335 23.164 28.293 1.00 40.41 N ATOM 1444 CA ALA B 324 -30.726 24.290 27.585 1.00 39.37 C ATOM 1445 C ALA B 324 -30.037 23.826 26.299 1.00 41.29 C ATOM 1446 O ALA B 324 -29.359 22.793 26.284 1.00 42.96 O ATOM 1447 CB ALA B 324 -29.743 25.014 28.484 1.00 36.77 C ATOM 1448 N LEU B 325 -30.231 24.576 25.216 1.00 41.36 N ATOM 1449 CA LEU B 325 -29.654 24.226 23.913 1.00 41.75 C ATOM 1450 C LEU B 325 -28.161 24.467 23.915 1.00 42.49 C ATOM 1451 O LEU B 325 -27.682 25.391 24.570 1.00 46.38 O ATOM 1452 CB LEU B 325 -30.298 25.062 22.805 1.00 40.15 C ATOM 1453 CG LEU B 325 -31.785 24.829 22.541 1.00 41.84 C ATOM 1454 CD1 LEU B 325 -32.377 25.991 21.756 1.00 40.83 C ATOM 1455 CD2 LEU B 325 -32.006 23.506 21.816 1.00 41.30 C ATOM 1456 N ARG B 326 -27.426 23.636 23.187 1.00 43.12 N ATOM 1457 CA ARG B 326 -25.995 23.855 22.997 1.00 44.88 C ATOM 1458 C ARG B 326 -25.773 25.028 22.050 1.00 47.45 C ATOM 1459 O ARG B 326 -26.477 25.165 21.047 1.00 47.21 O ATOM 1460 CB ARG B 326 -25.349 22.599 22.436 1.00 44.37 C ATOM 1461 CG ARG B 326 -23.864 22.730 22.154 1.00 42.26 C ATOM 1462 CD ARG B 326 -23.399 21.511 21.385 1.00 41.36 C ATOM 1463 NE ARG B 326 -21.968 21.553 21.098 1.00 43.06 N ATOM 1464 CZ ARG B 326 -21.212 20.478 20.874 1.00 44.41 C ATOM 1465 NH1 ARG B 326 -21.741 19.244 20.906 1.00 40.25 N ATOM 1466 NH2 ARG B 326 -19.918 20.634 20.618 1.00 43.14 N ATOM 1467 N GLU B 327 -24.803 25.880 22.372 1.00 51.92 N ATOM 1468 CA GLU B 327 -24.544 27.076 21.572 1.00 54.32 C ATOM 1469 C GLU B 327 -23.700 26.735 20.355 1.00 53.32 C ATOM 1470 O GLU B 327 -22.907 25.792 20.391 1.00 53.12 O ATOM 1471 CB GLU B 327 -23.824 28.132 22.407 1.00 60.53 C ATOM 1472 CG GLU B 327 -24.742 28.975 23.277 1.00 68.35 C ATOM 1473 CD GLU B 327 -24.160 29.217 24.657 1.00 73.51 C ATOM 1474 OE1 GLU B 327 -23.969 28.230 25.402 1.00 77.43 O ATOM 1475 OE2 GLU B 327 -23.900 30.388 25.001 1.00 74.97 O ATOM 1476 N ASN B 328 -23.872 27.513 19.287 1.00 51.03 N ATOM 1477 CA ASN B 328 -23.035 27.410 18.089 1.00 50.44 C ATOM 1478 C ASN B 328 -23.084 26.008 17.479 1.00 48.19 C ATOM 1479 O ASN B 328 -22.083 25.449 17.028 1.00 48.83 O ATOM 1480 CB ASN B 328 -21.591 27.855 18.392 1.00 53.57 C ATOM 1481 CG ASN B 328 -21.519 29.237 19.037 1.00 55.44 C ATOM 1482 OD1 ASN B 328 -20.832 29.424 20.039 1.00 60.94 O ATOM 1483 ND2 ASN B 328 -22.229 30.206 18.468 1.00 57.17 N ATOM 1484 N TRP B 329 -24.279 25.443 17.500 1.00 45.23 N ATOM 1485 CA TRP B 329 -24.532 24.138 16.949 1.00 42.30 C ATOM 1486 C TRP B 329 -25.315 24.305 15.691 1.00 44.00 C ATOM 1487 O TRP B 329 -25.034 23.647 14.680 1.00 42.81 O ATOM 1488 CB TRP B 329 -25.361 23.355 17.934 1.00 36.34 C ATOM 1489 CG TRP B 329 -25.634 21.937 17.526 1.00 32.53 C ATOM 1490 CD1 TRP B 329 -26.849 21.390 17.124 1.00 31.58 C ATOM 1491 CD2 TRP B 329 -24.677 20.822 17.491 1.00 30.16 C ATOM 1492 NE1 TRP B 329 -26.711 20.049 16.852 1.00 30.05 N ATOM 1493 CE2 TRP B 329 -25.435 19.646 17.057 1.00 29.58 C ATOM 1494 CE3 TRP B 329 -23.321 20.686 17.780 1.00 31.20 C ATOM 1495 CZ2 TRP B 329 -24.847 18.398 16.925 1.00 29.89 C ATOM 1496 CZ3 TRP B 329 -22.732 19.417 17.635 1.00 31.68 C ATOM 1497 CH2 TRP B 329 -23.482 18.302 17.224 1.00 30.51 C ATOM 1498 N LEU B 330 -26.327 25.169 15.779 1.00 43.52 N ATOM 1499 CA LEU B 330 -27.201 25.499 14.677 1.00 46.34 C ATOM 1500 C LEU B 330 -26.606 26.667 13.893 1.00 48.95 C ATOM 1501 O LEU B 330 -25.824 27.443 14.452 1.00 50.76 O ATOM 1502 CB LEU B 330 -28.578 25.874 15.217 1.00 45.28 C ATOM 1503 CG LEU B 330 -29.703 24.840 15.347 1.00 48.55 C ATOM 1504 CD1 LEU B 330 -29.239 23.399 15.467 1.00 49.14 C ATOM 1505 CD2 LEU B 330 -30.598 25.200 16.522 1.00 48.41 C ATOM 1506 N PRO B 331 -26.955 26.782 12.592 1.00 49.32 N ATOM 1507 CA PRO B 331 -26.566 27.919 11.750 1.00 53.87 C ATOM 1508 C PRO B 331 -27.119 29.246 12.275 1.00 57.54 C ATOM 1509 O PRO B 331 -28.283 29.303 12.677 1.00 57.20 O ATOM 1510 CB PRO B 331 -27.208 27.589 10.394 1.00 52.32 C ATOM 1511 CG PRO B 331 -28.291 26.610 10.701 1.00 49.69 C ATOM 1512 CD PRO B 331 -27.743 25.793 11.832 1.00 49.63 C ATOM 1513 N GLU B 332 -26.294 30.294 12.268 1.00 64.16 N ATOM 1514 CA GLU B 332 -26.694 31.596 12.807 1.00 74.02 C ATOM 1515 C GLU B 332 -27.495 32.394 11.784 1.00 80.79 C ATOM 1516 O GLU B 332 -27.042 32.602 10.656 1.00 85.05 O ATOM 1517 CB GLU B 332 -25.473 32.395 13.286 1.00 75.71 C ATOM 1518 N ASP B 333 -28.687 32.830 12.188 1.00 88.86 N ATOM 1519 CA ASP B 333 -29.587 33.609 11.325 1.00 98.39 C ATOM 1520 C ASP B 333 -29.123 35.060 11.133 1.00 99.26 C ATOM 1521 O ASP B 333 -28.435 35.619 11.994 1.00 98.78 O ATOM 1522 CB ASP B 333 -31.020 33.583 11.882 1.00100.86 C ATOM 1523 CG ASP B 333 -31.731 32.249 11.638 1.00103.37 C ATOM 1524 OD1 ASP B 333 -31.170 31.179 11.977 1.00101.95 O ATOM 1525 OD2 ASP B 333 -32.867 32.275 11.116 1.00100.94 O ATOM 1526 N LYS B 334 -29.507 35.658 10.004 1.00 99.33 N ATOM 1527 CA LYS B 334 -29.152 37.051 9.691 1.00101.69 C ATOM 1528 C LYS B 334 -30.343 38.008 9.810 1.00100.89 C ATOM 1529 O LYS B 334 -31.478 37.659 9.476 1.00 96.58 O ATOM 1530 CB LYS B 334 -28.494 37.160 8.304 1.00100.18 C ATOM 1531 CG LYS B 334 -29.395 36.816 7.120 1.00 96.92 C ATOM 1532 CD LYS B 334 -28.616 36.108 6.023 1.00 93.15 C ATOM 1533 CE LYS B 334 -28.351 34.656 6.399 1.00 95.88 C ATOM 1534 NZ LYS B 334 -27.320 34.030 5.527 1.00 94.36 N TER 1535 LYS B 334 HETATM 1536 N1 IMD A 201 -32.005 12.116 24.933 1.00 48.83 N HETATM 1537 C2 IMD A 201 -32.713 13.274 24.987 1.00 50.38 C HETATM 1538 N3 IMD A 201 -33.028 13.662 23.723 1.00 47.74 N HETATM 1539 C4 IMD A 201 -32.507 12.746 22.879 1.00 49.33 C HETATM 1540 C5 IMD A 201 -31.867 11.780 23.635 1.00 49.55 C HETATM 1541 C1 BME A 202 -23.433 10.760 18.847 0.50 49.23 C HETATM 1542 C2 BME A 202 -22.067 10.125 18.670 0.50 50.61 C HETATM 1543 O1 BME A 202 -24.333 9.721 19.244 0.50 50.18 O HETATM 1544 S2 BME A 202 -22.374 8.356 18.574 0.50 57.73 S HETATM 1545 ZN ZN A 203 -33.945 15.389 23.113 1.00 48.85 ZN HETATM 1546 ZN ZN B 501 -27.945 22.101 31.617 1.00 40.50 ZN HETATM 1547 O HOH A 301 -29.004 7.140 -2.559 1.00 46.69 O HETATM 1548 O HOH A 302 -30.687 -2.094 6.371 1.00 60.28 O HETATM 1549 O HOH A 303 -45.827 15.505 21.137 1.00 45.79 O HETATM 1550 O HOH A 304 -27.909 9.562 34.489 1.00 68.00 O HETATM 1551 O HOH A 305 -11.896 24.952 2.340 1.00 42.57 O HETATM 1552 O HOH A 306 -40.547 12.651 0.836 1.00 60.18 O HETATM 1553 O HOH A 307 -49.523 12.043 20.057 1.00 63.02 O HETATM 1554 O HOH A 308 -34.338 2.397 35.472 1.00 65.36 O HETATM 1555 O HOH A 309 -17.455 31.587 24.676 1.00 60.18 O HETATM 1556 O HOH A 310 -31.831 5.490 25.792 1.00 57.42 O HETATM 1557 O HOH A 311 -18.583 22.340 -1.695 1.00 48.52 O HETATM 1558 O HOH A 312 -35.198 3.903 2.577 1.00 58.02 O HETATM 1559 O HOH A 313 -35.976 0.797 20.351 1.00 65.00 O HETATM 1560 O HOH A 314 -40.050 20.561 25.321 1.00 47.92 O HETATM 1561 O HOH A 315 -38.171 0.065 16.355 1.00 64.48 O HETATM 1562 O HOH A 316 -34.763 23.001 34.954 1.00 57.98 O HETATM 1563 O HOH A 317 -7.639 30.609 17.490 1.00 58.06 O HETATM 1564 O HOH A 318 -40.653 27.610 6.064 1.00 61.10 O HETATM 1565 O HOH A 319 -40.435 -0.056 20.164 0.50 45.06 O HETATM 1566 O HOH A 320 -46.848 22.926 42.884 1.00 49.58 O HETATM 1567 O HOH A 321 -4.493 26.831 19.901 1.00 63.61 O HETATM 1568 O HOH A 322 -36.190 15.301 23.244 1.00 22.44 O HETATM 1569 O HOH A 323 -33.440 17.196 17.278 1.00 41.99 O HETATM 1570 O HOH A 324 -43.803 6.803 20.075 1.00 47.43 O HETATM 1571 O HOH A 325 -20.414 26.228 22.960 1.00 61.69 O HETATM 1572 O HOH A 326 -21.525 28.648 11.305 1.00 53.41 O HETATM 1573 O HOH A 327 -32.399 23.259 8.122 1.00 51.78 O HETATM 1574 O HOH A 328 -34.241 26.813 6.051 1.00 49.66 O HETATM 1575 O HOH A 329 -49.536 7.278 13.200 1.00 69.61 O HETATM 1576 O HOH A 330 -8.851 5.719 14.161 1.00 62.71 O HETATM 1577 O HOH A 331 -33.399 12.101 0.995 1.00 52.09 O HETATM 1578 O HOH A 332 -31.789 21.162 15.345 1.00 48.40 O HETATM 1579 O HOH A 333 -48.704 8.456 23.560 1.00 57.91 O HETATM 1580 O HOH A 334 -24.198 27.003 8.206 1.00 40.74 O HETATM 1581 O HOH A 335 -14.001 18.826 22.749 1.00 68.28 O HETATM 1582 O HOH A 336 -13.967 26.485 19.589 1.00 59.45 O HETATM 1583 O HOH A 337 -30.772 10.098 21.109 1.00 46.49 O HETATM 1584 O HOH A 338 -28.743 2.456 14.349 1.00 65.54 O HETATM 1585 O HOH A 339 -26.335 28.538 6.965 1.00 57.35 O HETATM 1586 O HOH A 340 -22.496 25.345 13.856 1.00 42.38 O HETATM 1587 O HOH A 341 -27.136 7.941 17.451 1.00 54.43 O HETATM 1588 O HOH A 342 -30.335 25.033 8.936 1.00 45.26 O HETATM 1589 O HOH A 343 -42.405 5.817 26.655 1.00 54.69 O HETATM 1590 O HOH A 344 -5.826 1.333 4.380 1.00 67.12 O HETATM 1591 O HOH A 345 -2.983 5.310 13.595 1.00120.97 O HETATM 1592 O HOH A 346 -3.733 5.331 3.863 1.00 54.83 O HETATM 1593 O HOH A 347 -7.116 18.154 19.796 1.00 48.24 O HETATM 1594 O HOH A 348 -6.827 1.422 12.824 1.00 65.32 O HETATM 1595 O HOH A 349 -0.518 8.796 18.318 1.00 82.46 O HETATM 1596 O HOH A 350 -37.250 19.031 16.254 1.00 44.90 O HETATM 1597 O HOH A 351 -27.076 31.539 -0.865 1.00 62.23 O HETATM 1598 O HOH A 352 -42.632 4.651 20.663 1.00 58.14 O HETATM 1599 O HOH A 353 -14.762 21.403 22.443 1.00 70.96 O HETATM 1600 O HOH A 354 -47.133 11.727 26.622 1.00 53.20 O HETATM 1601 O HOH A 355 -18.459 2.101 1.266 1.00 52.84 O HETATM 1602 O HOH A 356 -11.561 3.337 10.944 1.00 59.49 O HETATM 1603 O HOH A 357 -23.875 26.378 -0.553 1.00 67.14 O HETATM 1604 O HOH B 601 -22.227 15.842 34.439 1.00 52.83 O HETATM 1605 O HOH B 602 -24.714 30.722 31.032 1.00 67.52 O HETATM 1606 O HOH B 603 -33.398 25.467 29.622 1.00 58.13 O HETATM 1607 O HOH B 604 -22.578 19.136 37.840 1.00 52.06 O HETATM 1608 O HOH B 605 -18.026 2.341 26.822 1.00 60.19 O HETATM 1609 O HOH B 606 -24.126 28.778 36.304 1.00 52.58 O HETATM 1610 O HOH B 607 -35.325 23.930 24.106 1.00 52.99 O HETATM 1611 O HOH B 608 -35.022 20.531 22.789 1.00 71.39 O HETATM 1612 O HOH B 609 -24.301 18.429 20.437 1.00 36.58 O HETATM 1613 O HOH B 610 -26.318 15.268 25.095 1.00 46.19 O HETATM 1614 O HOH B 611 -26.713 26.788 27.901 1.00 46.76 O HETATM 1615 O HOH B 612 -17.962 7.329 26.944 1.00 60.59 O HETATM 1616 O HOH B 613 -15.134 23.160 37.148 1.00 61.48 O HETATM 1617 O HOH B 614 -25.801 29.711 19.286 1.00 50.77 O HETATM 1618 O HOH B 615 -33.512 14.242 30.739 1.00 36.63 O HETATM 1619 O HOH B 616 -19.385 17.680 21.524 1.00 46.05 O HETATM 1620 O HOH B 617 -26.611 13.726 30.690 1.00 55.47 O HETATM 1621 O HOH B 618 -23.128 25.340 24.992 1.00 41.38 O HETATM 1622 O HOH B 619 -28.661 11.200 26.559 1.00 50.74 O HETATM 1623 O HOH B 620 -24.915 25.223 27.065 1.00 42.68 O HETATM 1624 O HOH B 621 -20.976 7.095 25.480 1.00 62.30 O HETATM 1625 O HOH B 622 -21.192 23.826 19.409 1.00 51.72 O HETATM 1626 O HOH B 623 -28.194 28.498 20.654 1.00 48.39 O HETATM 1627 O HOH B 624 -26.316 3.044 25.762 1.00 75.04 O HETATM 1628 O HOH B 625 -16.854 18.597 22.988 1.00 62.21 O HETATM 1629 O HOH B 626 -18.655 19.279 34.853 1.00 60.82 O HETATM 1630 O HOH B 627 -36.855 18.299 23.183 1.00 55.16 O CONECT 105 1545 CONECT 1300 1546 CONECT 1319 1546 CONECT 1397 1545 CONECT 1403 1546 CONECT 1428 1546 CONECT 1536 1537 1540 CONECT 1537 1536 1538 CONECT 1538 1537 1539 1545 CONECT 1539 1538 1540 CONECT 1540 1536 1539 CONECT 1541 1542 1543 CONECT 1542 1541 1544 CONECT 1543 1541 CONECT 1544 1542 CONECT 1545 105 1397 1538 1568 CONECT 1546 1300 1319 1403 1428 CONECT 1568 1545 MASTER 459 0 4 7 9 0 6 6 1628 2 18 26 END
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Related entries of code: 4xxb
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB Code
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Protein Sequence Similarity
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Complexes with the same small molecule ligand
PDB Code
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Ligand Name
6im9
RCSB PDB
PDBbind
E3 ubiquitin-protein ligase Mdm2
Entry Information
PDB ID
4xxb
Complex Type
Protein-Protein
PDBbind Subset
general set
Protein Name
60S ribosomal protein L11, RPL11
Ligand Name
E3 ubiquitin-protein ligase Mdm2
EC.Number
E.C.-.-.-.-
Resolution
2.4(Å)
Affinity (Kd/Ki/IC50)
Kd=1.48uM
Release Year
2015
Protein/NA Sequence
Check fasta file
Primary Reference
(2015) Genes Dev. Vol. 29: pp. 1524-1534
Links to External Databases
RCSB PDB
The mother database
PDBsum
Enhanced annotations on PDB entries
Pubchem
Comprehensive collection of chemical and biological data
UniProtKB AC
UniProt accession number (AC):
P62913
Q00987
Entrez Gene ID
NCBI Entrez Gene ID:
6135
4193
ASD
Information of known allosteric effects of PDB entries
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