Browse entries in the PDBbind-CN Database
HEADER PEPTIDE BINDING PROTEIN 03-JAN-18 6FF3 TITLE CRYSTAL STRUCTURE OF DROSOPHILA NEURAL ECTODERMAL DEVELOPMENT FACTOR TITLE 2 IMP-L1 WITH HUMAN IGF-I COMPND MOL_ID: 1; COMPND 2 MOLECULE: NEURAL/ECTODERMAL DEVELOPMENT FACTOR IMP-L2; COMPND 3 CHAIN: A; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: INSULIN-LIKE GROWTH FACTOR I; COMPND 7 CHAIN: B; COMPND 8 SYNONYM: IGF-I,MECHANO GROWTH FACTOR,MGF,SOMATOMEDIN-C; COMPND 9 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: DROSOPHILA MELANOGASTER; SOURCE 3 ORGANISM_COMMON: FRUIT FLY; SOURCE 4 ORGANISM_TAXID: 7227; SOURCE 5 GENE: IMPL2, CG15009; SOURCE 6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 7108; SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: SF9; SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: FLASHBACK; SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PVL1392; SOURCE 11 MOL_ID: 2; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_COMMON: HUMAN; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 GENE: IGF1, IBP1; SOURCE 16 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 562 KEYWDS IGF-I, INSULIN BINDING PROTEIN, DROSOPHILA, IMAGINAL MORPHOGENESIS, KEYWDS 2 PEPTIDE BINDING PROTEIN EXPDTA X-RAY DIFFRACTION AUTHOR A.M.BRZOZOWSKI,N.KULAHIN,O.KRISTENSEN,G.SCHLUCKEBIER,P.D.MEYTS, AUTHOR 2 C.M.VIOLA REVDAT 2 03-OCT-18 6FF3 1 JRNL REVDAT 1 26-SEP-18 6FF3 0 JRNL AUTH N.K.ROED,C.M.VIOLA,O.KRISTENSEN,G.SCHLUCKEBIER,M.NORRMAN, JRNL AUTH 2 W.SAJID,J.D.WADE,A.S.ANDERSEN,C.KRISTENSEN,T.R.GANDERTON, JRNL AUTH 3 J.P.TURKENBURG,P.DE MEYTS,A.M.BRZOZOWSKI JRNL TITL STRUCTURES OF INSECT IMP-L2 SUGGEST AN ALTERNATIVE STRATEGY JRNL TITL 2 FOR REGULATING THE BIOAVAILABILITY OF INSULIN-LIKE HORMONES. JRNL REF NAT COMMUN V. 9 3860 2018 JRNL REFN ESSN 2041-1723 JRNL PMID 30242155 JRNL DOI 10.1038/S41467-018-06192-3 REMARK 2 REMARK 2 RESOLUTION. 2.57 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : REFMAC 5.8.0073 REMARK 3 AUTHORS : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER, REMARK 3 : NICHOLLS,WINN,LONG,VAGIN REMARK 3 REMARK 3 REFINEMENT TARGET : NULL REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.57 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 48.16 REMARK 3 DATA CUTOFF (SIGMA(F)) : NULL REMARK 3 COMPLETENESS FOR RANGE (%) : 95.7 REMARK 3 NUMBER OF REFLECTIONS : 10666 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3 R VALUE (WORKING + TEST SET) : 0.232 REMARK 3 R VALUE (WORKING SET) : 0.229 REMARK 3 FREE R VALUE : 0.285 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 4.800 REMARK 3 FREE R VALUE TEST SET COUNT : 535 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 2.57 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 2.64 REMARK 3 REFLECTION IN BIN (WORKING SET) : 772 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 95.18 REMARK 3 BIN R VALUE (WORKING SET) : 0.4810 REMARK 3 BIN FREE R VALUE SET COUNT : 38 REMARK 3 BIN FREE R VALUE : 0.6830 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 1886 REMARK 3 NUCLEIC ACID ATOMS : 0 REMARK 3 HETEROGEN ATOMS : 0 REMARK 3 SOLVENT ATOMS : 14 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : NULL REMARK 3 MEAN B VALUE (OVERALL, A**2) : 58.99 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : 3.14000 REMARK 3 B22 (A**2) : -3.46000 REMARK 3 B33 (A**2) : 0.26000 REMARK 3 B12 (A**2) : 0.00000 REMARK 3 B13 (A**2) : 0.30000 REMARK 3 B23 (A**2) : 0.00000 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A): 0.479 REMARK 3 ESU BASED ON FREE R VALUE (A): 0.319 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): 0.315 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 15.075 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.932 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.872 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A): 1928 ; 0.013 ; 0.019 REMARK 3 BOND LENGTHS OTHERS (A): 1786 ; 0.002 ; 0.020 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 2624 ; 1.676 ; 1.950 REMARK 3 BOND ANGLES OTHERS (DEGREES): 4106 ; 0.835 ; 3.000 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 243 ; 6.638 ; 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 82 ;33.586 ;23.780 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 311 ;24.866 ;15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 14 ;24.169 ;15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 302 ; 0.082 ; 0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A): 2163 ; 0.010 ; 0.021 REMARK 3 GENERAL PLANES OTHERS (A): 423 ; 0.001 ; 0.020 REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED CONTACTS OTHERS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 H-BOND (X...Y) OTHERS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 983 ; 4.107 ; 5.837 REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): 982 ; 4.089 ; 5.835 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 1221 ; 6.208 ; 8.737 REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): 1222 ; 6.207 ; 8.740 REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 945 ; 4.536 ; 6.241 REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): 945 ; 4.536 ; 6.241 REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): 1404 ; 7.040 ; 9.193 REMARK 3 LONG RANGE B REFINED ATOMS (A**2): 7677 ;11.001 ;55.217 REMARK 3 LONG RANGE B OTHER ATOMS (A**2): 7678 ;11.000 ;55.221 REMARK 3 REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : NULL REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED : NULL REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.20 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING REMARK 3 POSITIONS REMARK 4 REMARK 4 6FF3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 03-JAN-18. REMARK 100 THE DEPOSITION ID IS D_1200008199. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 28-FEB-13 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : 7.5 REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : DIAMOND REMARK 200 BEAMLINE : I03 REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 0.97625 REMARK 200 MONOCHROMATOR : NULL REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : PIXEL REMARK 200 DETECTOR MANUFACTURER : DECTRIS PILATUS3 S 6M REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS REMARK 200 DATA SCALING SOFTWARE : SCALA REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 10666 REMARK 200 RESOLUTION RANGE HIGH (A) : 2.570 REMARK 200 RESOLUTION RANGE LOW (A) : 48.160 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 96.4 REMARK 200 DATA REDUNDANCY : 3.900 REMARK 200 R MERGE (I) : 0.09300 REMARK 200 R SYM (I) : NULL REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : 3.9000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.57 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.64 REMARK 200 COMPLETENESS FOR SHELL (%) : 97.6 REMARK 200 DATA REDUNDANCY IN SHELL : 4.10 REMARK 200 R MERGE FOR SHELL (I) : 0.78300 REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 <I/SIGMA(I)> FOR SHELL : NULL REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: MOLREP REMARK 200 STARTING MODEL: 4CBP REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 54.70 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.72 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: CP 10 MG/ML, 4-8% W/V PEG 6K, 5-20 MM REMARK 280 MGCL2, 5 MM SB12, 0.1 M TRIS PH 7.5, VAPOR DIFFUSION, REMARK 280 TEMPERATURE 291K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -X,Y,-Z REMARK 290 3555 X+1/2,Y+1/2,Z REMARK 290 4555 -X+1/2,Y+1/2,-Z REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000 REMARK 290 SMTRY1 3 1.000000 0.000000 0.000000 41.01500 REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 47.07500 REMARK 290 SMTRY3 3 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 4 -1.000000 0.000000 0.000000 41.01500 REMARK 290 SMTRY2 4 0.000000 1.000000 0.000000 47.07500 REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 TOTAL BURIED SURFACE AREA: 1670 ANGSTROM**2 REMARK 350 SURFACE AREA OF THE COMPLEX: 12870 ANGSTROM**2 REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -10.0 KCAL/MOL REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 375 REMARK 375 SPECIAL POSITION REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL REMARK 375 POSITIONS. REMARK 375 REMARK 375 ATOM RES CSSEQI REMARK 375 HOH A 307 LIES ON A SPECIAL POSITION. REMARK 375 HOH A 309 LIES ON A SPECIAL POSITION. REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ARG A 1 REMARK 465 ALA A 2 REMARK 465 VAL A 3 REMARK 465 ASP A 4 REMARK 465 LEU A 5 REMARK 465 VAL A 6 REMARK 465 ASP A 7 REMARK 465 ASP A 8 REMARK 465 SER A 9 REMARK 465 ASN A 10 REMARK 465 ASP A 11 REMARK 465 VAL A 12 REMARK 465 ASP A 13 REMARK 465 ASN A 14 REMARK 465 SER A 15 REMARK 465 ILE A 16 REMARK 465 GLU A 17 REMARK 465 ALA A 18 REMARK 465 GLU A 19 REMARK 465 GLU A 20 REMARK 465 GLU A 21 REMARK 465 LYS A 22 REMARK 465 PRO A 23 REMARK 465 ARG A 24 REMARK 465 ASN A 25 REMARK 465 ARG A 26 REMARK 465 ALA A 27 REMARK 465 PHE A 28 REMARK 465 GLU A 29 REMARK 465 ALA A 86 REMARK 465 GLU A 87 REMARK 465 GLU A 88 REMARK 465 GLU A 240 REMARK 465 GLU A 241 REMARK 465 ASP A 242 REMARK 465 GLY B 22 REMARK 465 PHE B 23 REMARK 465 TYR B 24 REMARK 465 PHE B 25 REMARK 465 ASN B 26 REMARK 465 LYS B 27 REMARK 465 PRO B 28 REMARK 465 THR B 29 REMARK 465 GLY B 30 REMARK 465 TYR B 31 REMARK 465 GLY B 32 REMARK 465 SER B 33 REMARK 465 SER B 34 REMARK 465 SER B 35 REMARK 465 ARG B 36 REMARK 465 ARG B 37 REMARK 465 ALA B 38 REMARK 465 PRO B 39 REMARK 465 GLN B 40 REMARK 465 THR B 41 REMARK 465 GLY B 42 REMARK 465 ALA B 62 REMARK 465 PRO B 63 REMARK 465 LEU B 64 REMARK 465 LYS B 65 REMARK 465 PRO B 66 REMARK 465 ALA B 67 REMARK 465 LYS B 68 REMARK 465 SER B 69 REMARK 465 ALA B 70 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LYS A 37 CD CE NZ REMARK 470 LYS A 42 CE NZ REMARK 470 ILE A 51 CD1 REMARK 470 LEU A 72 CD1 CD2 REMARK 470 GLN A 84 CG CD OE1 NE2 REMARK 470 VAL A 85 CG1 CG2 REMARK 470 ALA A 89 CB REMARK 470 ARG A 97 NE CZ NH1 NH2 REMARK 470 GLU A 108 OE1 OE2 REMARK 470 ARG A 133 CG CD NE CZ NH1 NH2 REMARK 470 LYS A 141 CD CE NZ REMARK 470 LYS A 148 CE NZ REMARK 470 LEU A 159 CD1 CD2 REMARK 470 MET A 162 O REMARK 470 LYS A 188 CG CD CE NZ REMARK 470 GLU A 212 CG CD OE1 OE2 REMARK 470 LEU B 54 CG CD1 CD2 REMARK 470 ARG B 55 CG CD NE CZ NH1 NH2 REMARK 470 ARG B 56 NE CZ NH1 NH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 O GLY A 145 NH1 ARG A 175 1.91 REMARK 500 OG1 THR A 36 OE2 GLU A 56 1.94 REMARK 500 OE1 GLN A 66 NH1 ARG A 117 1.99 REMARK 500 NH2 ARG A 195 OD2 ASP A 213 1.99 REMARK 500 OD1 ASP A 47 OG SER A 135 2.14 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 PRO A 90 C - N - CD ANGL. DEV. = -25.5 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 GLN A 61 -132.24 47.67 REMARK 500 ASP A 78 -8.56 78.37 REMARK 500 ASP B 20 -71.08 -139.14 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 LEU A 77 ASP A 78 -33.04 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 4CBP RELATED DB: PDB REMARK 900 CRYSTAL STRUCTURE OF THE APO-IMP-L2 PROTEIN REMARK 900 RELATED ID: 1GZR RELATED DB: PDB REMARK 900 CRYSTAL STRUCTURE OF HUMAN IGF-I DBREF 6FF3 A 1 242 UNP Q09024 IMPL2_DROME 26 267 DBREF 6FF3 B 1 70 UNP P05019 IGF1_HUMAN 49 118 SEQRES 1 A 242 ARG ALA VAL ASP LEU VAL ASP ASP SER ASN ASP VAL ASP SEQRES 2 A 242 ASN SER ILE GLU ALA GLU GLU GLU LYS PRO ARG ASN ARG SEQRES 3 A 242 ALA PHE GLU ALA ASP TRP LEU LYS PHE THR LYS THR PRO SEQRES 4 A 242 PRO THR LYS LEU GLN GLN ALA ASP GLY ALA THR ILE GLU SEQRES 5 A 242 ILE VAL CYS GLU MET MET GLY SER GLN VAL PRO SER ILE SEQRES 6 A 242 GLN TRP VAL VAL GLY HIS LEU PRO ARG SER GLU LEU ASP SEQRES 7 A 242 ASP LEU ASP SER ASN GLN VAL ALA GLU GLU ALA PRO SER SEQRES 8 A 242 ALA ILE VAL ARG VAL ARG SER SER HIS ILE ILE ASP HIS SEQRES 9 A 242 VAL LEU SER GLU ALA ARG THR TYR THR CYS VAL GLY ARG SEQRES 10 A 242 THR GLY SER LYS THR ILE TYR ALA SER THR VAL VAL HIS SEQRES 11 A 242 PRO PRO ARG SER SER ARG LEU THR PRO GLU LYS THR TYR SEQRES 12 A 242 PRO GLY ALA GLN LYS PRO ARG ILE ILE TYR THR GLU LYS SEQRES 13 A 242 THR HIS LEU ASP LEU MET GLY SER ASN ILE GLN LEU PRO SEQRES 14 A 242 CYS ARG VAL HIS ALA ARG PRO ARG ALA GLU ILE THR TRP SEQRES 15 A 242 LEU ASN ASN GLU ASN LYS GLU ILE VAL GLN GLY HIS ARG SEQRES 16 A 242 HIS ARG VAL LEU ALA ASN GLY ASP LEU LEU ILE SER GLU SEQRES 17 A 242 ILE LYS TRP GLU ASP MET GLY ASN TYR LYS CYS ILE ALA SEQRES 18 A 242 ARG ASN VAL VAL GLY LYS ASP THR ALA ASP THR PHE VAL SEQRES 19 A 242 TYR PRO VAL LEU ASN GLU GLU ASP SEQRES 1 B 70 GLY PRO GLU THR LEU CYS GLY ALA GLU LEU VAL ASP ALA SEQRES 2 B 70 LEU GLN PHE VAL CYS GLY ASP ARG GLY PHE TYR PHE ASN SEQRES 3 B 70 LYS PRO THR GLY TYR GLY SER SER SER ARG ARG ALA PRO SEQRES 4 B 70 GLN THR GLY ILE VAL ASP GLU CYS CYS PHE ARG SER CYS SEQRES 5 B 70 ASP LEU ARG ARG LEU GLU MET TYR CYS ALA PRO LEU LYS SEQRES 6 B 70 PRO ALA LYS SER ALA FORMUL 3 HOH *14(H2 O) HELIX 1 AA1 PRO A 73 LEU A 77 5 5 HELIX 2 AA2 LYS A 210 MET A 214 5 5 HELIX 3 AA3 PRO B 2 ASP B 20 1 19 HELIX 4 AA4 VAL B 44 ARG B 50 1 7 HELIX 5 AA5 ASP B 53 MET B 59 1 7 SHEET 1 AA1 5 LEU A 33 LYS A 37 0 SHEET 2 AA1 5 ILE A 51 SER A 60 -1 O MET A 58 N LYS A 34 SHEET 3 AA1 5 ILE A 93 ILE A 102 -1 O HIS A 100 N ILE A 53 SHEET 4 AA1 5 GLN A 147 LEU A 161 -1 O THR A 154 N ARG A 97 SHEET 5 AA1 5 CYS A 170 ARG A 175 -1 O ARG A 175 N GLN A 147 SHEET 1 AA2 7 LEU A 33 LYS A 37 0 SHEET 2 AA2 7 ILE A 51 SER A 60 -1 O MET A 58 N LYS A 34 SHEET 3 AA2 7 ILE A 93 ILE A 102 -1 O HIS A 100 N ILE A 53 SHEET 4 AA2 7 GLN A 147 LEU A 161 -1 O THR A 154 N ARG A 97 SHEET 5 AA2 7 GLY A 226 VAL A 237 1 O VAL A 237 N ASP A 160 SHEET 6 AA2 7 GLY A 215 ASN A 223 -1 N GLY A 215 O VAL A 234 SHEET 7 AA2 7 GLU A 179 LEU A 183 -1 N THR A 181 O ILE A 220 SHEET 1 AA3 4 LYS A 42 GLN A 44 0 SHEET 2 AA3 4 LYS A 121 HIS A 130 1 O VAL A 128 N LEU A 43 SHEET 3 AA3 4 ARG A 110 THR A 118 -1 N ARG A 110 O VAL A 129 SHEET 4 AA3 4 SER A 64 VAL A 69 -1 N GLN A 66 O VAL A 115 SHEET 1 AA4 3 ILE A 166 LEU A 168 0 SHEET 2 AA4 3 LEU A 204 ILE A 206 -1 O LEU A 204 N LEU A 168 SHEET 3 AA4 3 HIS A 196 VAL A 198 -1 N ARG A 197 O LEU A 205 SSBOND 1 CYS A 55 CYS A 114 1555 1555 2.07 SSBOND 2 CYS A 170 CYS A 219 1555 1555 2.04 SSBOND 3 CYS B 6 CYS B 48 1555 1555 2.05 SSBOND 4 CYS B 18 CYS B 61 1555 1555 2.02 SSBOND 5 CYS B 47 CYS B 52 1555 1555 2.05 CISPEP 1 ALA A 30 ASP A 31 0 5.91 CISPEP 2 ARG A 175 PRO A 176 0 0.49 CRYST1 82.030 94.150 48.360 90.00 95.26 90.00 C 1 2 1 4 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.012191 0.000000 0.001122 0.00000 SCALE2 0.000000 0.010621 0.000000 0.00000 SCALE3 0.000000 0.000000 0.020766 0.00000 ATOM 1 N ALA A 30 -17.998 -4.085 -2.139 1.00 97.81 N ATOM 2 CA ALA A 30 -18.671 -2.808 -1.768 1.00 94.23 C ATOM 3 C ALA A 30 -17.600 -1.800 -1.409 1.00 99.11 C ATOM 4 O ALA A 30 -16.479 -2.191 -1.070 1.00109.80 O ATOM 5 CB ALA A 30 -19.615 -3.021 -0.591 1.00 90.20 C ATOM 6 N ASP A 31 -17.927 -0.514 -1.439 1.00 91.98 N ATOM 7 CA ASP A 31 -19.283 -0.018 -1.675 1.00 90.05 C ATOM 8 C ASP A 31 -19.212 0.904 -2.864 1.00 79.55 C ATOM 9 O ASP A 31 -18.274 1.696 -3.004 1.00 73.61 O ATOM 10 CB ASP A 31 -19.852 0.711 -0.434 1.00 93.26 C ATOM 11 CG ASP A 31 -18.765 1.109 0.578 1.00 98.61 C ATOM 12 OD1 ASP A 31 -18.306 0.229 1.332 1.00106.65 O ATOM 13 OD2 ASP A 31 -18.359 2.290 0.627 1.00 93.37 O ATOM 14 N TRP A 32 -20.187 0.797 -3.748 1.00 71.56 N ATOM 15 CA TRP A 32 -20.231 1.727 -4.856 1.00 67.90 C ATOM 16 C TRP A 32 -21.641 1.873 -5.375 1.00 63.27 C ATOM 17 O TRP A 32 -22.472 0.983 -5.190 1.00 56.93 O ATOM 18 CB TRP A 32 -19.272 1.296 -5.964 1.00 63.32 C ATOM 19 CG TRP A 32 -19.632 0.020 -6.580 1.00 61.78 C ATOM 20 CD1 TRP A 32 -19.439 -1.211 -6.060 1.00 60.42 C ATOM 21 CD2 TRP A 32 -20.273 -0.167 -7.847 1.00 58.57 C ATOM 22 NE1 TRP A 32 -19.904 -2.164 -6.927 1.00 61.92 N ATOM 23 CE2 TRP A 32 -20.413 -1.551 -8.040 1.00 59.26 C ATOM 24 CE3 TRP A 32 -20.737 0.699 -8.834 1.00 54.53 C ATOM 25 CZ2 TRP A 32 -20.997 -2.094 -9.185 1.00 52.49 C ATOM 26 CZ3 TRP A 32 -21.307 0.155 -9.976 1.00 52.08 C ATOM 27 CH2 TRP A 32 -21.435 -1.223 -10.134 1.00 50.86 C ATOM 28 N LEU A 33 -21.885 3.002 -6.035 1.00 61.90 N ATOM 29 CA LEU A 33 -23.211 3.341 -6.512 1.00 55.39 C ATOM 30 C LEU A 33 -23.065 4.388 -7.583 1.00 49.89 C ATOM 31 O LEU A 33 -22.410 5.370 -7.374 1.00 53.49 O ATOM 32 CB LEU A 33 -24.010 3.889 -5.336 1.00 53.72 C ATOM 33 CG LEU A 33 -25.464 4.250 -5.545 1.00 53.41 C ATOM 34 CD1 LEU A 33 -26.314 3.009 -5.783 1.00 53.09 C ATOM 35 CD2 LEU A 33 -25.934 5.015 -4.304 1.00 53.91 C ATOM 36 N LYS A 34 -23.667 4.180 -8.740 1.00 54.22 N ATOM 37 CA LYS A 34 -23.646 5.198 -9.771 1.00 51.88 C ATOM 38 C LYS A 34 -24.894 5.175 -10.624 1.00 53.96 C ATOM 39 O LYS A 34 -25.597 4.189 -10.667 1.00 53.13 O ATOM 40 CB LYS A 34 -22.417 5.052 -10.649 1.00 52.04 C ATOM 41 CG LYS A 34 -22.372 3.759 -11.424 1.00 60.45 C ATOM 42 CD LYS A 34 -21.078 3.600 -12.192 1.00 63.99 C ATOM 43 CE LYS A 34 -21.243 4.050 -13.625 1.00 66.52 C ATOM 44 NZ LYS A 34 -19.947 4.053 -14.343 1.00 71.11 N ATOM 45 N PHE A 35 -25.163 6.286 -11.292 1.00 54.60 N ATOM 46 CA PHE A 35 -26.270 6.401 -12.216 1.00 51.60 C ATOM 47 C PHE A 35 -25.855 5.786 -13.514 1.00 54.58 C ATOM 48 O PHE A 35 -24.703 5.873 -13.889 1.00 57.16 O ATOM 49 CB PHE A 35 -26.567 7.861 -12.516 1.00 53.89 C ATOM 50 CG PHE A 35 -27.349 8.554 -11.447 1.00 54.96 C ATOM 51 CD1 PHE A 35 -28.686 8.286 -11.293 1.00 51.71 C ATOM 52 CD2 PHE A 35 -26.741 9.489 -10.603 1.00 59.61 C ATOM 53 CE1 PHE A 35 -29.418 8.903 -10.310 1.00 53.45 C ATOM 54 CE2 PHE A 35 -27.466 10.123 -9.613 1.00 58.68 C ATOM 55 CZ PHE A 35 -28.816 9.826 -9.473 1.00 58.57 C ATOM 56 N THR A 36 -26.804 5.176 -14.202 1.00 54.16 N ATOM 57 CA THR A 36 -26.601 4.685 -15.553 1.00 52.77 C ATOM 58 C THR A 36 -27.550 5.389 -16.574 1.00 54.99 C ATOM 59 O THR A 36 -27.267 5.495 -17.776 1.00 54.59 O ATOM 60 CB THR A 36 -26.851 3.171 -15.546 1.00 49.86 C ATOM 61 OG1 THR A 36 -28.100 2.905 -14.897 1.00 49.52 O ATOM 62 CG2 THR A 36 -25.765 2.458 -14.770 1.00 47.57 C ATOM 63 N LYS A 37 -28.702 5.826 -16.080 1.00 53.90 N ATOM 64 CA LYS A 37 -29.646 6.642 -16.826 1.00 53.03 C ATOM 65 C LYS A 37 -30.003 7.713 -15.845 1.00 54.93 C ATOM 66 O LYS A 37 -30.745 7.453 -14.905 1.00 51.96 O ATOM 67 CB LYS A 37 -30.913 5.855 -17.194 1.00 51.15 C ATOM 68 CG LYS A 37 -31.579 6.262 -18.495 1.00 46.51 C ATOM 69 N THR A 38 -29.432 8.896 -16.035 1.00 55.44 N ATOM 70 CA THR A 38 -29.722 10.030 -15.180 1.00 53.37 C ATOM 71 C THR A 38 -30.745 10.913 -15.930 1.00 53.63 C ATOM 72 O THR A 38 -30.662 11.082 -17.136 1.00 53.37 O ATOM 73 CB THR A 38 -28.446 10.817 -14.719 1.00 54.89 C ATOM 74 OG1 THR A 38 -28.590 12.231 -14.959 1.00 50.76 O ATOM 75 CG2 THR A 38 -27.186 10.350 -15.419 1.00 52.69 C ATOM 76 N PRO A 39 -31.738 11.426 -15.211 1.00 51.08 N ATOM 77 CA PRO A 39 -32.775 12.198 -15.818 1.00 52.06 C ATOM 78 C PRO A 39 -32.256 13.500 -16.341 1.00 54.57 C ATOM 79 O PRO A 39 -31.232 13.975 -15.878 1.00 54.84 O ATOM 80 CB PRO A 39 -33.726 12.506 -14.648 1.00 56.28 C ATOM 81 CG PRO A 39 -33.035 12.066 -13.412 1.00 53.18 C ATOM 82 CD PRO A 39 -32.087 11.010 -13.844 1.00 53.55 C ATOM 83 N PRO A 40 -32.977 14.093 -17.290 1.00 57.00 N ATOM 84 CA PRO A 40 -32.632 15.428 -17.742 1.00 54.76 C ATOM 85 C PRO A 40 -32.986 16.396 -16.675 1.00 56.98 C ATOM 86 O PRO A 40 -33.909 16.130 -15.915 1.00 57.92 O ATOM 87 CB PRO A 40 -33.526 15.643 -18.970 1.00 59.53 C ATOM 88 CG PRO A 40 -34.615 14.632 -18.847 1.00 61.78 C ATOM 89 CD PRO A 40 -34.021 13.464 -18.119 1.00 60.49 C ATOM 90 N THR A 41 -32.286 17.526 -16.639 1.00 56.77 N ATOM 91 CA THR A 41 -32.403 18.445 -15.522 1.00 54.35 C ATOM 92 C THR A 41 -33.638 19.314 -15.578 1.00 58.32 C ATOM 93 O THR A 41 -34.076 19.841 -14.557 1.00 60.47 O ATOM 94 CB THR A 41 -31.171 19.341 -15.447 1.00 55.68 C ATOM 95 OG1 THR A 41 -30.712 19.607 -16.772 1.00 54.55 O ATOM 96 CG2 THR A 41 -30.056 18.634 -14.667 1.00 56.73 C ATOM 97 N LYS A 42 -34.191 19.487 -16.770 1.00 59.73 N ATOM 98 CA LYS A 42 -35.322 20.365 -16.954 1.00 57.94 C ATOM 99 C LYS A 42 -36.197 19.763 -18.011 1.00 61.09 C ATOM 100 O LYS A 42 -35.707 19.168 -18.968 1.00 59.36 O ATOM 101 CB LYS A 42 -34.872 21.738 -17.413 1.00 62.56 C ATOM 102 CG LYS A 42 -36.033 22.651 -17.796 1.00 69.53 C ATOM 103 CD LYS A 42 -35.606 23.839 -18.656 1.00 72.22 C ATOM 104 N LEU A 43 -37.498 19.908 -17.836 1.00 60.61 N ATOM 105 CA LEU A 43 -38.429 19.417 -18.813 1.00 58.08 C ATOM 106 C LEU A 43 -39.535 20.411 -18.980 1.00 59.76 C ATOM 107 O LEU A 43 -39.815 21.215 -18.110 1.00 58.88 O ATOM 108 CB LEU A 43 -39.002 18.071 -18.396 1.00 57.22 C ATOM 109 CG LEU A 43 -38.178 16.821 -18.717 1.00 62.72 C ATOM 110 CD1 LEU A 43 -39.091 15.646 -19.042 1.00 63.51 C ATOM 111 CD2 LEU A 43 -37.184 17.014 -19.861 1.00 63.48 C ATOM 112 N GLN A 44 -40.159 20.360 -20.136 1.00 65.25 N ATOM 113 CA GLN A 44 -41.211 21.277 -20.456 1.00 64.20 C ATOM 114 C GLN A 44 -42.435 20.425 -20.627 1.00 60.19 C ATOM 115 O GLN A 44 -42.489 19.575 -21.506 1.00 57.22 O ATOM 116 CB GLN A 44 -40.898 22.027 -21.743 1.00 64.78 C ATOM 117 CG GLN A 44 -42.121 22.604 -22.444 1.00 71.13 C ATOM 118 CD GLN A 44 -42.823 23.678 -21.632 1.00 71.71 C ATOM 119 OE1 GLN A 44 -42.179 24.576 -21.073 1.00 71.40 O ATOM 120 NE2 GLN A 44 -44.151 23.595 -21.571 1.00 72.16 N ATOM 121 N GLN A 45 -43.415 20.666 -19.777 1.00 55.70 N ATOM 122 CA GLN A 45 -44.649 19.953 -19.861 1.00 56.97 C ATOM 123 C GLN A 45 -45.497 20.484 -21.006 1.00 59.46 C ATOM 124 O GLN A 45 -45.540 21.683 -21.255 1.00 57.18 O ATOM 125 CB GLN A 45 -45.414 20.083 -18.549 1.00 53.17 C ATOM 126 CG GLN A 45 -46.519 19.050 -18.437 1.00 50.82 C ATOM 127 CD GLN A 45 -47.165 19.021 -17.069 1.00 47.55 C ATOM 128 OE1 GLN A 45 -47.204 20.021 -16.363 1.00 44.74 O ATOM 129 NE2 GLN A 45 -47.683 17.863 -16.695 1.00 49.01 N ATOM 130 N ALA A 46 -46.151 19.560 -21.694 1.00 62.80 N ATOM 131 CA ALA A 46 -47.125 19.879 -22.710 1.00 66.59 C ATOM 132 C ALA A 46 -48.442 19.869 -22.006 1.00 73.86 C ATOM 133 O ALA A 46 -48.518 19.437 -20.857 1.00 74.24 O ATOM 134 CB ALA A 46 -47.118 18.815 -23.779 1.00 67.83 C ATOM 135 N ASP A 47 -49.491 20.321 -22.684 1.00 78.72 N ATOM 136 CA ASP A 47 -50.804 20.375 -22.044 1.00 81.83 C ATOM 137 C ASP A 47 -51.494 19.014 -22.069 1.00 69.93 C ATOM 138 O ASP A 47 -51.814 18.483 -23.113 1.00 65.23 O ATOM 139 CB ASP A 47 -51.687 21.448 -22.686 1.00 89.14 C ATOM 140 CG ASP A 47 -53.044 21.569 -22.010 1.00 88.15 C ATOM 141 OD1 ASP A 47 -53.130 21.976 -20.835 1.00 87.98 O ATOM 142 OD2 ASP A 47 -54.039 21.243 -22.674 1.00 97.38 O ATOM 143 N GLY A 48 -51.704 18.449 -20.897 1.00 68.92 N ATOM 144 CA GLY A 48 -52.427 17.203 -20.792 1.00 73.53 C ATOM 145 C GLY A 48 -51.633 15.926 -20.961 1.00 75.39 C ATOM 146 O GLY A 48 -52.208 14.839 -20.931 1.00 77.08 O ATOM 147 N ALA A 49 -50.320 16.018 -21.104 1.00 77.58 N ATOM 148 CA ALA A 49 -49.552 14.817 -21.423 1.00 82.06 C ATOM 149 C ALA A 49 -48.677 14.301 -20.260 1.00 76.25 C ATOM 150 O ALA A 49 -47.876 15.030 -19.677 1.00 84.12 O ATOM 151 CB ALA A 49 -48.722 15.052 -22.674 1.00 84.85 C ATOM 152 N THR A 50 -48.836 13.020 -19.964 1.00 64.91 N ATOM 153 CA THR A 50 -48.153 12.375 -18.869 1.00 59.94 C ATOM 154 C THR A 50 -46.653 12.257 -19.089 1.00 61.67 C ATOM 155 O THR A 50 -46.180 11.687 -20.078 1.00 58.46 O ATOM 156 CB THR A 50 -48.689 10.971 -18.716 1.00 59.31 C ATOM 157 OG1 THR A 50 -48.738 10.373 -20.017 1.00 68.09 O ATOM 158 CG2 THR A 50 -50.076 11.016 -18.164 1.00 61.35 C ATOM 159 N ILE A 51 -45.910 12.795 -18.135 1.00 61.60 N ATOM 160 CA ILE A 51 -44.465 12.717 -18.121 1.00 55.59 C ATOM 161 C ILE A 51 -44.096 11.491 -17.288 1.00 56.75 C ATOM 162 O ILE A 51 -44.786 11.136 -16.331 1.00 54.29 O ATOM 163 CB ILE A 51 -43.890 14.000 -17.484 1.00 55.36 C ATOM 164 CG1 ILE A 51 -43.959 15.175 -18.473 1.00 51.08 C ATOM 165 CG2 ILE A 51 -42.477 13.786 -16.982 1.00 52.99 C ATOM 166 N GLU A 52 -43.005 10.848 -17.661 1.00 59.66 N ATOM 167 CA GLU A 52 -42.457 9.740 -16.902 1.00 57.50 C ATOM 168 C GLU A 52 -40.983 9.995 -16.764 1.00 53.28 C ATOM 169 O GLU A 52 -40.261 9.823 -17.725 1.00 56.54 O ATOM 170 CB GLU A 52 -42.706 8.452 -17.669 1.00 61.87 C ATOM 171 CG GLU A 52 -42.377 7.163 -16.935 1.00 66.83 C ATOM 172 CD GLU A 52 -43.250 6.013 -17.382 1.00 67.11 C ATOM 173 OE1 GLU A 52 -44.428 6.256 -17.743 1.00 69.76 O ATOM 174 OE2 GLU A 52 -42.754 4.868 -17.372 1.00 69.69 O ATOM 175 N ILE A 53 -40.537 10.412 -15.582 1.00 50.44 N ATOM 176 CA ILE A 53 -39.115 10.698 -15.354 1.00 47.41 C ATOM 177 C ILE A 53 -38.416 9.429 -14.955 1.00 43.99 C ATOM 178 O ILE A 53 -38.762 8.813 -13.953 1.00 49.45 O ATOM 179 CB ILE A 53 -38.879 11.665 -14.189 1.00 50.05 C ATOM 180 CG1 ILE A 53 -39.958 12.752 -14.176 1.00 48.50 C ATOM 181 CG2 ILE A 53 -37.473 12.248 -14.279 1.00 48.12 C ATOM 182 CD1 ILE A 53 -39.575 13.981 -13.397 1.00 48.08 C ATOM 183 N VAL A 54 -37.428 9.035 -15.725 1.00 42.90 N ATOM 184 CA VAL A 54 -36.754 7.765 -15.472 1.00 45.63 C ATOM 185 C VAL A 54 -35.400 7.960 -14.915 1.00 44.28 C ATOM 186 O VAL A 54 -34.628 8.727 -15.474 1.00 49.45 O ATOM 187 CB VAL A 54 -36.555 6.997 -16.752 1.00 47.11 C ATOM 188 CG1 VAL A 54 -35.913 5.657 -16.441 1.00 47.58 C ATOM 189 CG2 VAL A 54 -37.896 6.870 -17.475 1.00 50.21 C ATOM 190 N CYS A 55 -35.105 7.299 -13.810 1.00 45.45 N ATOM 191 CA CYS A 55 -33.758 7.356 -13.311 1.00 52.45 C ATOM 192 C CYS A 55 -33.335 5.934 -13.040 1.00 51.57 C ATOM 193 O CYS A 55 -34.136 5.106 -12.610 1.00 52.53 O ATOM 194 CB CYS A 55 -33.640 8.333 -12.140 1.00 59.34 C ATOM 195 SG CYS A 55 -33.521 7.685 -10.478 1.00 72.60 S ATOM 196 N GLU A 56 -32.097 5.620 -13.390 1.00 51.24 N ATOM 197 CA GLU A 56 -31.630 4.247 -13.319 1.00 52.10 C ATOM 198 C GLU A 56 -30.223 4.223 -12.770 1.00 50.49 C ATOM 199 O GLU A 56 -29.434 5.152 -13.023 1.00 45.91 O ATOM 200 CB GLU A 56 -31.647 3.650 -14.703 1.00 55.12 C ATOM 201 CG GLU A 56 -31.607 2.145 -14.733 1.00 61.41 C ATOM 202 CD GLU A 56 -30.702 1.656 -15.842 1.00 68.86 C ATOM 203 OE1 GLU A 56 -31.227 1.178 -16.870 1.00 66.08 O ATOM 204 OE2 GLU A 56 -29.470 1.775 -15.685 1.00 72.86 O ATOM 205 N MET A 57 -29.895 3.190 -12.007 1.00 46.81 N ATOM 206 CA MET A 57 -28.603 3.181 -11.371 1.00 49.96 C ATOM 207 C MET A 57 -28.116 1.796 -11.062 1.00 49.66 C ATOM 208 O MET A 57 -28.880 0.834 -11.060 1.00 45.90 O ATOM 209 CB MET A 57 -28.608 4.040 -10.114 1.00 55.88 C ATOM 210 CG MET A 57 -29.912 4.026 -9.343 1.00 62.60 C ATOM 211 SD MET A 57 -29.715 4.885 -7.764 1.00 69.13 S ATOM 212 CE MET A 57 -30.658 6.386 -8.081 1.00 67.41 C ATOM 213 N MET A 58 -26.808 1.716 -10.848 1.00 50.79 N ATOM 214 CA MET A 58 -26.126 0.454 -10.650 1.00 50.96 C ATOM 215 C MET A 58 -25.267 0.594 -9.421 1.00 47.08 C ATOM 216 O MET A 58 -24.721 1.680 -9.156 1.00 42.27 O ATOM 217 CB MET A 58 -25.254 0.141 -11.856 1.00 50.36 C ATOM 218 CG MET A 58 -24.802 -1.301 -11.868 1.00 52.36 C ATOM 219 SD MET A 58 -24.224 -1.806 -13.494 1.00 52.37 S ATOM 220 CE MET A 58 -24.502 -3.565 -13.420 1.00 48.41 C ATOM 221 N GLY A 59 -25.144 -0.487 -8.675 1.00 45.38 N ATOM 222 CA GLY A 59 -24.319 -0.454 -7.481 1.00 55.20 C ATOM 223 C GLY A 59 -24.203 -1.773 -6.752 1.00 56.20 C ATOM 224 O GLY A 59 -24.837 -2.770 -7.119 1.00 57.11 O ATOM 225 N SER A 60 -23.391 -1.771 -5.705 1.00 54.84 N ATOM 226 CA SER A 60 -23.161 -2.980 -4.921 1.00 55.32 C ATOM 227 C SER A 60 -24.419 -3.378 -4.203 1.00 48.68 C ATOM 228 O SER A 60 -25.287 -2.579 -4.004 1.00 49.66 O ATOM 229 CB SER A 60 -22.012 -2.791 -3.911 1.00 56.67 C ATOM 230 OG SER A 60 -22.177 -1.624 -3.096 1.00 57.81 O ATOM 231 N GLN A 61 -24.502 -4.636 -3.832 1.00 51.69 N ATOM 232 CA GLN A 61 -25.638 -5.158 -3.152 1.00 57.94 C ATOM 233 C GLN A 61 -26.893 -4.727 -3.858 1.00 56.62 C ATOM 234 O GLN A 61 -26.973 -4.883 -5.062 1.00 57.31 O ATOM 235 CB GLN A 61 -25.614 -4.733 -1.703 1.00 64.44 C ATOM 236 CG GLN A 61 -25.158 -3.316 -1.502 1.00 75.14 C ATOM 237 CD GLN A 61 -24.116 -3.240 -0.449 1.00 77.71 C ATOM 238 OE1 GLN A 61 -24.429 -3.224 0.744 1.00 89.22 O ATOM 239 NE2 GLN A 61 -22.866 -3.201 -0.867 1.00 76.56 N ATOM 240 N VAL A 62 -27.887 -4.220 -3.131 1.00 54.99 N ATOM 241 CA VAL A 62 -29.131 -3.859 -3.762 1.00 50.91 C ATOM 242 C VAL A 62 -29.503 -2.432 -3.466 1.00 49.50 C ATOM 243 O VAL A 62 -30.047 -2.131 -2.419 1.00 56.08 O ATOM 244 CB VAL A 62 -30.282 -4.768 -3.335 1.00 52.45 C ATOM 245 CG1 VAL A 62 -31.530 -4.491 -4.192 1.00 53.26 C ATOM 246 CG2 VAL A 62 -29.854 -6.224 -3.455 1.00 53.02 C ATOM 247 N PRO A 63 -29.220 -1.543 -4.410 1.00 47.35 N ATOM 248 CA PRO A 63 -29.633 -0.175 -4.309 1.00 47.73 C ATOM 249 C PRO A 63 -31.123 0.011 -4.179 1.00 51.10 C ATOM 250 O PRO A 63 -31.944 -0.822 -4.657 1.00 54.04 O ATOM 251 CB PRO A 63 -29.156 0.415 -5.631 1.00 43.81 C ATOM 252 CG PRO A 63 -27.895 -0.295 -5.840 1.00 45.17 C ATOM 253 CD PRO A 63 -28.301 -1.712 -5.542 1.00 46.70 C ATOM 254 N SER A 64 -31.455 1.113 -3.519 1.00 49.57 N ATOM 255 CA SER A 64 -32.835 1.451 -3.266 1.00 49.19 C ATOM 256 C SER A 64 -33.019 2.878 -3.740 1.00 43.01 C ATOM 257 O SER A 64 -32.237 3.769 -3.420 1.00 47.42 O ATOM 258 CB SER A 64 -33.214 1.267 -1.779 1.00 48.47 C ATOM 259 OG SER A 64 -33.127 2.485 -1.048 1.00 51.51 O ATOM 260 N ILE A 65 -34.067 3.071 -4.514 1.00 40.65 N ATOM 261 CA ILE A 65 -34.416 4.391 -5.049 1.00 43.10 C ATOM 262 C ILE A 65 -35.735 4.842 -4.484 1.00 41.08 C ATOM 263 O ILE A 65 -36.660 4.059 -4.280 1.00 45.79 O ATOM 264 CB ILE A 65 -34.567 4.343 -6.569 1.00 42.20 C ATOM 265 CG1 ILE A 65 -33.359 3.667 -7.186 1.00 40.98 C ATOM 266 CG2 ILE A 65 -34.639 5.734 -7.146 1.00 49.69 C ATOM 267 CD1 ILE A 65 -33.419 3.583 -8.677 1.00 40.26 C ATOM 268 N GLN A 66 -35.831 6.119 -4.236 1.00 44.75 N ATOM 269 CA GLN A 66 -37.088 6.672 -3.788 1.00 49.42 C ATOM 270 C GLN A 66 -37.120 8.054 -4.388 1.00 40.86 C ATOM 271 O GLN A 66 -36.089 8.561 -4.770 1.00 47.58 O ATOM 272 CB GLN A 66 -37.154 6.623 -2.250 1.00 53.85 C ATOM 273 CG GLN A 66 -37.170 7.979 -1.564 1.00 64.16 C ATOM 274 CD GLN A 66 -36.347 8.020 -0.302 1.00 73.25 C ATOM 275 OE1 GLN A 66 -35.559 7.112 -0.028 1.00 85.77 O ATOM 276 NE2 GLN A 66 -36.494 9.102 0.462 1.00 72.04 N ATOM 277 N TRP A 67 -38.284 8.656 -4.530 1.00 44.20 N ATOM 278 CA TRP A 67 -38.357 10.008 -5.101 1.00 44.86 C ATOM 279 C TRP A 67 -38.805 10.978 -4.036 1.00 45.69 C ATOM 280 O TRP A 67 -39.474 10.590 -3.082 1.00 47.26 O ATOM 281 CB TRP A 67 -39.328 10.079 -6.272 1.00 43.42 C ATOM 282 CG TRP A 67 -38.948 9.258 -7.455 1.00 41.92 C ATOM 283 CD1 TRP A 67 -39.165 7.928 -7.614 1.00 43.40 C ATOM 284 CD2 TRP A 67 -38.324 9.708 -8.649 1.00 38.87 C ATOM 285 NE1 TRP A 67 -38.713 7.517 -8.837 1.00 44.47 N ATOM 286 CE2 TRP A 67 -38.182 8.601 -9.489 1.00 43.12 C ATOM 287 CE3 TRP A 67 -37.885 10.937 -9.095 1.00 45.21 C ATOM 288 CZ2 TRP A 67 -37.595 8.685 -10.745 1.00 43.50 C ATOM 289 CZ3 TRP A 67 -37.297 11.022 -10.360 1.00 48.52 C ATOM 290 CH2 TRP A 67 -37.161 9.901 -11.160 1.00 46.76 C ATOM 291 N VAL A 68 -38.420 12.239 -4.198 1.00 48.64 N ATOM 292 CA VAL A 68 -38.952 13.310 -3.362 1.00 51.14 C ATOM 293 C VAL A 68 -39.345 14.503 -4.247 1.00 52.90 C ATOM 294 O VAL A 68 -38.731 14.790 -5.286 1.00 48.85 O ATOM 295 CB VAL A 68 -37.986 13.720 -2.198 1.00 53.35 C ATOM 296 CG1 VAL A 68 -36.843 12.728 -2.020 1.00 56.50 C ATOM 297 CG2 VAL A 68 -37.407 15.109 -2.387 1.00 53.40 C ATOM 298 N VAL A 69 -40.384 15.200 -3.822 1.00 56.60 N ATOM 299 CA VAL A 69 -40.868 16.373 -4.536 1.00 61.42 C ATOM 300 C VAL A 69 -40.407 17.682 -3.858 1.00 59.98 C ATOM 301 O VAL A 69 -40.226 17.734 -2.661 1.00 61.25 O ATOM 302 CB VAL A 69 -42.392 16.327 -4.604 1.00 58.87 C ATOM 303 CG1 VAL A 69 -42.892 17.325 -5.618 1.00 63.94 C ATOM 304 CG2 VAL A 69 -42.844 14.927 -4.973 1.00 57.82 C ATOM 305 N GLY A 70 -40.214 18.745 -4.622 1.00 60.61 N ATOM 306 CA GLY A 70 -39.780 20.006 -4.028 1.00 63.13 C ATOM 307 C GLY A 70 -38.328 19.958 -3.623 1.00 60.23 C ATOM 308 O GLY A 70 -37.620 19.037 -3.967 1.00 61.78 O ATOM 309 N HIS A 71 -37.885 20.971 -2.900 1.00 71.30 N ATOM 310 CA HIS A 71 -36.513 21.028 -2.419 1.00 76.35 C ATOM 311 C HIS A 71 -36.510 20.408 -1.054 1.00 71.60 C ATOM 312 O HIS A 71 -37.283 20.807 -0.192 1.00 64.58 O ATOM 313 CB HIS A 71 -36.030 22.475 -2.333 1.00 85.14 C ATOM 314 CG HIS A 71 -36.478 23.323 -3.485 1.00 93.96 C ATOM 315 ND1 HIS A 71 -37.578 24.153 -3.409 1.00 96.60 N ATOM 316 CD2 HIS A 71 -36.005 23.439 -4.750 1.00 94.66 C ATOM 317 CE1 HIS A 71 -37.754 24.755 -4.571 1.00 97.01 C ATOM 318 NE2 HIS A 71 -36.813 24.341 -5.401 1.00 99.04 N ATOM 319 N LEU A 72 -35.657 19.414 -0.868 1.00 70.49 N ATOM 320 CA LEU A 72 -35.531 18.739 0.406 1.00 67.16 C ATOM 321 C LEU A 72 -34.236 19.254 1.004 1.00 68.46 C ATOM 322 O LEU A 72 -33.201 19.213 0.318 1.00 70.21 O ATOM 323 CB LEU A 72 -35.466 17.220 0.203 1.00 61.30 C ATOM 324 CG LEU A 72 -35.827 16.352 1.407 1.00 55.16 C ATOM 325 N PRO A 73 -34.266 19.755 2.264 1.00 68.44 N ATOM 326 CA PRO A 73 -32.944 20.057 2.793 1.00 67.21 C ATOM 327 C PRO A 73 -32.154 18.758 2.890 1.00 66.47 C ATOM 328 O PRO A 73 -32.692 17.697 3.223 1.00 70.01 O ATOM 329 CB PRO A 73 -33.246 20.638 4.181 1.00 67.73 C ATOM 330 CG PRO A 73 -34.530 19.988 4.561 1.00 70.27 C ATOM 331 CD PRO A 73 -35.315 19.979 3.287 1.00 71.28 C ATOM 332 N ARG A 74 -30.891 18.861 2.560 1.00 65.78 N ATOM 333 CA ARG A 74 -30.021 17.731 2.388 1.00 69.41 C ATOM 334 C ARG A 74 -29.904 16.917 3.662 1.00 63.75 C ATOM 335 O ARG A 74 -29.592 15.733 3.630 1.00 52.37 O ATOM 336 CB ARG A 74 -28.646 18.243 1.965 1.00 79.49 C ATOM 337 CG ARG A 74 -28.203 19.493 2.738 1.00 90.18 C ATOM 338 CD ARG A 74 -28.861 20.780 2.235 1.00 93.13 C ATOM 339 NE ARG A 74 -28.408 21.941 2.993 1.00 94.74 N ATOM 340 CZ ARG A 74 -28.408 23.195 2.539 1.00 95.83 C ATOM 341 NH1 ARG A 74 -28.833 23.475 1.306 1.00 93.96 N ATOM 342 NH2 ARG A 74 -27.969 24.179 3.320 1.00 90.79 N ATOM 343 N SER A 75 -30.146 17.562 4.793 1.00 65.27 N ATOM 344 CA SER A 75 -30.048 16.897 6.075 1.00 64.35 C ATOM 345 C SER A 75 -31.106 15.830 6.224 1.00 60.22 C ATOM 346 O SER A 75 -31.011 14.977 7.105 1.00 65.42 O ATOM 347 CB SER A 75 -30.209 17.923 7.201 1.00 68.37 C ATOM 348 OG SER A 75 -31.438 18.636 7.094 1.00 75.78 O ATOM 349 N GLU A 76 -32.102 15.859 5.344 1.00 59.63 N ATOM 350 CA GLU A 76 -33.356 15.205 5.628 1.00 62.04 C ATOM 351 C GLU A 76 -33.472 13.756 5.271 1.00 62.36 C ATOM 352 O GLU A 76 -34.569 13.204 5.343 1.00 73.67 O ATOM 353 CB GLU A 76 -34.523 15.975 5.019 1.00 63.09 C ATOM 354 CG GLU A 76 -34.998 17.074 5.944 1.00 67.52 C ATOM 355 CD GLU A 76 -35.219 16.572 7.360 1.00 67.25 C ATOM 356 OE1 GLU A 76 -35.261 17.423 8.279 1.00 65.57 O ATOM 357 OE2 GLU A 76 -35.331 15.329 7.554 1.00 77.54 O ATOM 358 N LEU A 77 -32.356 13.104 4.985 1.00 57.85 N ATOM 359 CA LEU A 77 -32.400 11.684 4.684 1.00 59.61 C ATOM 360 C LEU A 77 -31.405 10.831 5.517 1.00 61.72 C ATOM 361 O LEU A 77 -30.212 11.029 5.326 1.00 63.02 O ATOM 362 CB LEU A 77 -32.084 11.507 3.202 1.00 64.48 C ATOM 363 CG LEU A 77 -32.221 12.766 2.305 1.00 66.77 C ATOM 364 CD1 LEU A 77 -31.131 13.775 2.581 1.00 68.54 C ATOM 365 CD2 LEU A 77 -32.211 12.473 0.820 1.00 67.33 C ATOM 366 N ASP A 78 -31.802 9.973 6.487 1.00 57.49 N ATOM 367 CA ASP A 78 -32.975 10.118 7.398 1.00 61.50 C ATOM 368 C ASP A 78 -34.405 9.789 6.868 1.00 62.49 C ATOM 369 O ASP A 78 -35.391 9.694 7.632 1.00 49.23 O ATOM 370 CB ASP A 78 -32.952 11.513 8.060 1.00 68.68 C ATOM 371 CG ASP A 78 -33.126 11.452 9.611 1.00 73.64 C ATOM 372 OD1 ASP A 78 -32.468 10.599 10.257 1.00 67.57 O ATOM 373 OD2 ASP A 78 -33.901 12.267 10.182 1.00 62.92 O ATOM 374 N ASP A 79 -34.503 9.563 5.566 1.00 63.48 N ATOM 375 CA ASP A 79 -35.742 9.184 4.940 1.00 58.34 C ATOM 376 C ASP A 79 -35.618 7.759 4.496 1.00 51.82 C ATOM 377 O ASP A 79 -36.537 7.210 3.947 1.00 48.18 O ATOM 378 CB ASP A 79 -35.983 10.056 3.731 1.00 65.02 C ATOM 379 CG ASP A 79 -36.844 11.242 4.047 1.00 72.51 C ATOM 380 OD1 ASP A 79 -36.716 11.798 5.161 1.00 85.58 O ATOM 381 OD2 ASP A 79 -37.652 11.636 3.185 1.00 71.92 O ATOM 382 N LEU A 80 -34.455 7.180 4.749 1.00 54.16 N ATOM 383 CA LEU A 80 -34.150 5.798 4.440 1.00 61.66 C ATOM 384 C LEU A 80 -35.215 4.934 5.080 1.00 60.27 C ATOM 385 O LEU A 80 -35.862 5.352 6.044 1.00 66.96 O ATOM 386 CB LEU A 80 -32.770 5.451 5.003 1.00 61.48 C ATOM 387 CG LEU A 80 -31.923 4.494 4.190 1.00 67.59 C ATOM 388 CD1 LEU A 80 -30.571 4.198 4.856 1.00 66.11 C ATOM 389 CD2 LEU A 80 -32.687 3.224 3.900 1.00 74.00 C ATOM 390 N ASP A 81 -35.432 3.749 4.549 1.00 58.54 N ATOM 391 CA ASP A 81 -36.571 2.980 4.979 1.00 63.38 C ATOM 392 C ASP A 81 -36.278 1.680 5.686 1.00 61.87 C ATOM 393 O ASP A 81 -37.092 1.240 6.478 1.00 70.30 O ATOM 394 CB ASP A 81 -37.465 2.790 3.775 1.00 69.59 C ATOM 395 CG ASP A 81 -37.701 4.094 3.074 1.00 81.47 C ATOM 396 OD1 ASP A 81 -37.836 5.114 3.797 1.00 77.16 O ATOM 397 OD2 ASP A 81 -37.706 4.114 1.820 1.00 98.32 O ATOM 398 N SER A 82 -35.150 1.047 5.409 1.00 63.05 N ATOM 399 CA SER A 82 -34.688 -0.021 6.282 1.00 63.88 C ATOM 400 C SER A 82 -33.191 0.049 6.258 1.00 61.08 C ATOM 401 O SER A 82 -32.603 0.277 5.217 1.00 54.41 O ATOM 402 CB SER A 82 -35.185 -1.404 5.828 1.00 63.29 C ATOM 403 OG SER A 82 -35.362 -2.242 6.956 1.00 55.52 O ATOM 404 N ASN A 83 -32.580 -0.110 7.417 1.00 60.99 N ATOM 405 CA ASN A 83 -31.148 -0.233 7.485 1.00 63.36 C ATOM 406 C ASN A 83 -30.873 -1.560 8.173 1.00 59.90 C ATOM 407 O ASN A 83 -30.435 -1.623 9.307 1.00 65.21 O ATOM 408 CB ASN A 83 -30.535 0.930 8.246 1.00 65.06 C ATOM 409 CG ASN A 83 -31.346 2.205 8.134 1.00 73.41 C ATOM 410 OD1 ASN A 83 -32.575 2.176 7.935 1.00 80.04 O ATOM 411 ND2 ASN A 83 -30.667 3.351 8.304 1.00 68.48 N ATOM 412 N GLN A 84 -31.174 -2.624 7.456 1.00 58.53 N ATOM 413 CA GLN A 84 -30.975 -3.970 7.910 1.00 59.10 C ATOM 414 C GLN A 84 -29.705 -4.471 7.225 1.00 62.52 C ATOM 415 O GLN A 84 -29.399 -4.074 6.095 1.00 59.33 O ATOM 416 CB GLN A 84 -32.179 -4.839 7.524 1.00 48.77 C ATOM 417 N VAL A 85 -28.941 -5.301 7.924 1.00 68.46 N ATOM 418 CA VAL A 85 -27.753 -5.908 7.329 1.00 73.36 C ATOM 419 C VAL A 85 -28.215 -6.772 6.160 1.00 74.17 C ATOM 420 O VAL A 85 -29.235 -7.464 6.266 1.00 74.74 O ATOM 421 CB VAL A 85 -26.971 -6.764 8.349 1.00 64.46 C ATOM 422 N ALA A 89 -26.792 -8.676 3.887 1.00 68.74 N ATOM 423 CA ALA A 89 -27.411 -9.799 3.172 1.00 83.67 C ATOM 424 C ALA A 89 -26.567 -10.393 2.004 1.00 88.69 C ATOM 425 O ALA A 89 -26.504 -11.593 1.826 1.00 77.58 O ATOM 426 N PRO A 90 -26.034 -9.543 1.130 1.00 94.40 N ATOM 427 CA PRO A 90 -25.288 -10.097 -0.007 1.00 91.44 C ATOM 428 C PRO A 90 -24.072 -9.363 -0.624 1.00 86.28 C ATOM 429 O PRO A 90 -23.747 -8.239 -0.283 1.00 77.98 O ATOM 430 CB PRO A 90 -26.390 -10.184 -1.058 1.00 92.65 C ATOM 431 CG PRO A 90 -27.222 -8.968 -0.785 1.00 93.94 C ATOM 432 CD PRO A 90 -27.193 -8.740 0.703 1.00 97.00 C ATOM 433 N SER A 91 -23.441 -10.038 -1.578 1.00 91.45 N ATOM 434 CA SER A 91 -22.405 -9.459 -2.421 1.00 88.51 C ATOM 435 C SER A 91 -22.955 -9.322 -3.843 1.00 82.70 C ATOM 436 O SER A 91 -22.236 -9.452 -4.830 1.00 74.86 O ATOM 437 CB SER A 91 -21.187 -10.379 -2.425 1.00 92.70 C ATOM 438 OG SER A 91 -20.008 -9.625 -2.600 1.00 92.80 O ATOM 439 N ALA A 92 -24.247 -9.057 -3.946 1.00 76.81 N ATOM 440 CA ALA A 92 -24.892 -8.924 -5.246 1.00 70.02 C ATOM 441 C ALA A 92 -24.567 -7.589 -5.886 1.00 66.32 C ATOM 442 O ALA A 92 -24.111 -6.668 -5.202 1.00 63.13 O ATOM 443 CB ALA A 92 -26.396 -9.056 -5.100 1.00 72.46 C ATOM 444 N ILE A 93 -24.813 -7.493 -7.193 1.00 58.93 N ATOM 445 CA ILE A 93 -24.721 -6.234 -7.918 1.00 56.42 C ATOM 446 C ILE A 93 -26.002 -6.003 -8.706 1.00 55.33 C ATOM 447 O ILE A 93 -26.382 -6.831 -9.529 1.00 57.70 O ATOM 448 CB ILE A 93 -23.540 -6.256 -8.877 1.00 59.82 C ATOM 449 CG1 ILE A 93 -22.246 -6.293 -8.062 1.00 62.46 C ATOM 450 CG2 ILE A 93 -23.557 -5.034 -9.806 1.00 61.55 C ATOM 451 CD1 ILE A 93 -21.079 -6.837 -8.842 1.00 63.74 C ATOM 452 N VAL A 94 -26.647 -4.862 -8.494 1.00 46.30 N ATOM 453 CA VAL A 94 -27.951 -4.636 -9.067 1.00 44.11 C ATOM 454 C VAL A 94 -27.986 -3.369 -9.862 1.00 42.65 C ATOM 455 O VAL A 94 -27.309 -2.403 -9.551 1.00 42.48 O ATOM 456 CB VAL A 94 -29.036 -4.548 -7.977 1.00 51.98 C ATOM 457 CG1 VAL A 94 -30.395 -4.185 -8.572 1.00 52.57 C ATOM 458 CG2 VAL A 94 -29.140 -5.858 -7.215 1.00 52.47 C ATOM 459 N ARG A 95 -28.797 -3.385 -10.913 1.00 43.20 N ATOM 460 CA ARG A 95 -29.051 -2.206 -11.733 1.00 40.35 C ATOM 461 C ARG A 95 -30.542 -2.050 -11.668 1.00 39.85 C ATOM 462 O ARG A 95 -31.266 -2.942 -12.102 1.00 38.37 O ATOM 463 CB ARG A 95 -28.598 -2.521 -13.138 1.00 43.05 C ATOM 464 CG ARG A 95 -28.630 -1.400 -14.130 1.00 43.98 C ATOM 465 CD ARG A 95 -27.811 -1.836 -15.311 1.00 46.71 C ATOM 466 NE ARG A 95 -28.346 -1.329 -16.568 1.00 54.26 N ATOM 467 CZ ARG A 95 -28.738 -2.070 -17.600 1.00 52.44 C ATOM 468 NH1 ARG A 95 -28.663 -3.389 -17.570 1.00 52.16 N ATOM 469 NH2 ARG A 95 -29.188 -1.470 -18.693 1.00 59.79 N ATOM 470 N VAL A 96 -31.028 -0.953 -11.094 1.00 40.37 N ATOM 471 CA VAL A 96 -32.458 -0.856 -10.808 1.00 40.02 C ATOM 472 C VAL A 96 -32.985 0.417 -11.389 1.00 38.22 C ATOM 473 O VAL A 96 -32.326 1.410 -11.328 1.00 44.06 O ATOM 474 CB VAL A 96 -32.706 -0.992 -9.284 1.00 45.65 C ATOM 475 CG1 VAL A 96 -31.671 -0.223 -8.487 1.00 48.37 C ATOM 476 CG2 VAL A 96 -34.095 -0.553 -8.894 1.00 46.35 C ATOM 477 N ARG A 97 -34.160 0.377 -11.986 1.00 39.27 N ATOM 478 CA ARG A 97 -34.727 1.527 -12.711 1.00 42.25 C ATOM 479 C ARG A 97 -36.057 1.917 -12.084 1.00 43.04 C ATOM 480 O ARG A 97 -36.925 1.074 -11.993 1.00 46.18 O ATOM 481 CB ARG A 97 -34.999 1.121 -14.172 1.00 43.63 C ATOM 482 CG ARG A 97 -35.755 2.134 -15.040 1.00 42.99 C ATOM 483 CD ARG A 97 -36.485 1.438 -16.176 1.00 42.52 C ATOM 484 N SER A 98 -36.229 3.179 -11.684 1.00 41.75 N ATOM 485 CA SER A 98 -37.482 3.646 -11.112 1.00 42.27 C ATOM 486 C SER A 98 -37.970 4.837 -11.885 1.00 44.02 C ATOM 487 O SER A 98 -37.163 5.677 -12.326 1.00 46.14 O ATOM 488 CB SER A 98 -37.286 4.081 -9.655 1.00 48.02 C ATOM 489 OG SER A 98 -38.538 4.411 -9.011 1.00 48.54 O ATOM 490 N SER A 99 -39.284 4.971 -12.024 1.00 44.18 N ATOM 491 CA SER A 99 -39.819 6.121 -12.771 1.00 45.56 C ATOM 492 C SER A 99 -40.842 6.864 -11.952 1.00 43.14 C ATOM 493 O SER A 99 -41.505 6.277 -11.140 1.00 46.86 O ATOM 494 CB SER A 99 -40.416 5.659 -14.083 1.00 43.45 C ATOM 495 OG SER A 99 -39.476 4.831 -14.748 1.00 46.30 O ATOM 496 N HIS A 100 -40.946 8.166 -12.165 1.00 45.06 N ATOM 497 CA HIS A 100 -42.009 8.957 -11.577 1.00 45.43 C ATOM 498 C HIS A 100 -42.951 9.471 -12.642 1.00 44.58 C ATOM 499 O HIS A 100 -42.544 10.182 -13.547 1.00 43.22 O ATOM 500 CB HIS A 100 -41.426 10.136 -10.830 1.00 46.57 C ATOM 501 CG HIS A 100 -42.439 10.908 -10.062 1.00 48.00 C ATOM 502 ND1 HIS A 100 -42.813 10.583 -8.770 1.00 51.44 N ATOM 503 CD2 HIS A 100 -43.174 11.987 -10.409 1.00 50.14 C ATOM 504 CE1 HIS A 100 -43.735 11.440 -8.359 1.00 51.02 C ATOM 505 NE2 HIS A 100 -43.953 12.318 -9.326 1.00 48.19 N ATOM 506 N ILE A 101 -44.209 9.095 -12.524 1.00 47.51 N ATOM 507 CA ILE A 101 -45.240 9.541 -13.447 1.00 49.98 C ATOM 508 C ILE A 101 -45.893 10.767 -12.906 1.00 47.77 C ATOM 509 O ILE A 101 -46.344 10.778 -11.789 1.00 48.31 O ATOM 510 CB ILE A 101 -46.376 8.535 -13.629 1.00 51.63 C ATOM 511 CG1 ILE A 101 -45.823 7.124 -13.820 1.00 54.70 C ATOM 512 CG2 ILE A 101 -47.221 8.953 -14.818 1.00 56.38 C ATOM 513 CD1 ILE A 101 -44.587 7.054 -14.690 1.00 58.07 C ATOM 514 N ILE A 102 -45.924 11.800 -13.716 1.00 49.66 N ATOM 515 CA ILE A 102 -46.686 12.974 -13.425 1.00 47.42 C ATOM 516 C ILE A 102 -47.849 12.907 -14.378 1.00 51.62 C ATOM 517 O ILE A 102 -47.668 12.928 -15.620 1.00 51.64 O ATOM 518 CB ILE A 102 -45.883 14.202 -13.786 1.00 50.16 C ATOM 519 CG1 ILE A 102 -44.628 14.250 -12.941 1.00 52.83 C ATOM 520 CG2 ILE A 102 -46.696 15.460 -13.569 1.00 50.67 C ATOM 521 CD1 ILE A 102 -43.590 15.191 -13.498 1.00 52.82 C ATOM 522 N ASP A 103 -49.046 12.796 -13.834 1.00 53.61 N ATOM 523 CA ASP A 103 -50.215 12.797 -14.691 1.00 57.80 C ATOM 524 C ASP A 103 -51.259 13.777 -14.179 1.00 53.72 C ATOM 525 O ASP A 103 -52.346 13.395 -13.792 1.00 55.95 O ATOM 526 CB ASP A 103 -50.768 11.384 -14.857 1.00 58.35 C ATOM 527 CG ASP A 103 -51.151 10.753 -13.551 1.00 60.31 C ATOM 528 OD1 ASP A 103 -50.954 11.400 -12.512 1.00 63.20 O ATOM 529 OD2 ASP A 103 -51.651 9.606 -13.560 1.00 62.76 O ATOM 530 N HIS A 104 -50.884 15.043 -14.182 1.00 53.14 N ATOM 531 CA HIS A 104 -51.795 16.137 -13.921 1.00 54.16 C ATOM 532 C HIS A 104 -50.986 17.337 -14.323 1.00 54.11 C ATOM 533 O HIS A 104 -49.757 17.238 -14.378 1.00 53.77 O ATOM 534 CB HIS A 104 -52.215 16.201 -12.466 1.00 56.47 C ATOM 535 CG HIS A 104 -51.074 16.200 -11.504 1.00 58.06 C ATOM 536 ND1 HIS A 104 -50.305 17.317 -11.273 1.00 58.27 N ATOM 537 CD2 HIS A 104 -50.604 15.237 -10.678 1.00 59.46 C ATOM 538 CE1 HIS A 104 -49.388 17.037 -10.368 1.00 59.11 C ATOM 539 NE2 HIS A 104 -49.549 15.781 -9.990 1.00 62.88 N ATOM 540 N VAL A 105 -51.643 18.446 -14.644 1.00 50.79 N ATOM 541 CA VAL A 105 -50.935 19.588 -15.187 1.00 47.29 C ATOM 542 C VAL A 105 -50.470 20.440 -14.040 1.00 46.10 C ATOM 543 O VAL A 105 -51.259 20.808 -13.162 1.00 49.29 O ATOM 544 CB VAL A 105 -51.814 20.445 -16.116 1.00 48.43 C ATOM 545 CG1 VAL A 105 -50.960 21.403 -16.915 1.00 51.49 C ATOM 546 CG2 VAL A 105 -52.589 19.582 -17.075 1.00 49.04 C ATOM 547 N LEU A 106 -49.196 20.795 -14.064 1.00 45.88 N ATOM 548 CA LEU A 106 -48.610 21.575 -12.986 1.00 47.63 C ATOM 549 C LEU A 106 -49.096 22.973 -13.151 1.00 52.20 C ATOM 550 O LEU A 106 -49.244 23.439 -14.265 1.00 62.35 O ATOM 551 CB LEU A 106 -47.088 21.546 -13.090 1.00 47.72 C ATOM 552 CG LEU A 106 -46.459 20.140 -13.067 1.00 43.65 C ATOM 553 CD1 LEU A 106 -44.960 20.237 -13.183 1.00 45.69 C ATOM 554 CD2 LEU A 106 -46.810 19.402 -11.793 1.00 47.59 C ATOM 555 N SER A 107 -49.373 23.646 -12.053 1.00 60.81 N ATOM 556 CA SER A 107 -49.703 25.060 -12.117 1.00 61.91 C ATOM 557 C SER A 107 -48.438 25.883 -11.882 1.00 66.93 C ATOM 558 O SER A 107 -48.476 27.112 -11.958 1.00 74.30 O ATOM 559 CB SER A 107 -50.768 25.421 -11.078 1.00 61.84 C ATOM 560 OG SER A 107 -50.410 24.926 -9.804 1.00 62.07 O ATOM 561 N GLU A 108 -47.319 25.225 -11.591 1.00 63.78 N ATOM 562 CA GLU A 108 -46.095 25.957 -11.307 1.00 66.39 C ATOM 563 C GLU A 108 -44.923 25.004 -11.324 1.00 67.34 C ATOM 564 O GLU A 108 -45.097 23.826 -11.014 1.00 67.73 O ATOM 565 CB GLU A 108 -46.181 26.680 -9.953 1.00 67.38 C ATOM 566 CG GLU A 108 -46.337 25.777 -8.739 1.00 67.96 C ATOM 567 CD GLU A 108 -46.344 26.551 -7.428 1.00 65.97 C ATOM 568 N ALA A 109 -43.742 25.512 -11.696 1.00 62.64 N ATOM 569 CA ALA A 109 -42.557 24.670 -11.845 1.00 58.73 C ATOM 570 C ALA A 109 -42.350 23.850 -10.586 1.00 58.04 C ATOM 571 O ALA A 109 -42.577 24.349 -9.474 1.00 57.92 O ATOM 572 CB ALA A 109 -41.325 25.500 -12.123 1.00 57.63 C ATOM 573 N ARG A 110 -41.970 22.586 -10.766 1.00 51.57 N ATOM 574 CA ARG A 110 -41.685 21.726 -9.631 1.00 52.86 C ATOM 575 C ARG A 110 -40.517 20.827 -9.933 1.00 54.67 C ATOM 576 O ARG A 110 -40.214 20.528 -11.093 1.00 56.30 O ATOM 577 CB ARG A 110 -42.887 20.869 -9.312 1.00 55.39 C ATOM 578 CG ARG A 110 -43.171 20.798 -7.846 1.00 53.68 C ATOM 579 CD ARG A 110 -44.254 19.787 -7.555 1.00 55.00 C ATOM 580 NE ARG A 110 -45.604 20.139 -7.991 1.00 57.19 N ATOM 581 CZ ARG A 110 -46.233 21.251 -7.649 1.00 56.36 C ATOM 582 NH1 ARG A 110 -45.626 22.163 -6.906 1.00 59.29 N ATOM 583 NH2 ARG A 110 -47.466 21.464 -8.071 1.00 58.65 N ATOM 584 N THR A 111 -39.857 20.393 -8.879 1.00 54.34 N ATOM 585 CA THR A 111 -38.682 19.587 -9.042 1.00 54.83 C ATOM 586 C THR A 111 -38.982 18.219 -8.485 1.00 46.40 C ATOM 587 O THR A 111 -39.650 18.075 -7.469 1.00 47.49 O ATOM 588 CB THR A 111 -37.472 20.208 -8.329 1.00 56.02 C ATOM 589 OG1 THR A 111 -37.500 19.845 -6.946 1.00 59.79 O ATOM 590 CG2 THR A 111 -37.492 21.720 -8.458 1.00 53.66 C ATOM 591 N TYR A 112 -38.493 17.217 -9.167 1.00 42.40 N ATOM 592 CA TYR A 112 -38.615 15.862 -8.682 1.00 45.92 C ATOM 593 C TYR A 112 -37.196 15.360 -8.619 1.00 45.33 C ATOM 594 O TYR A 112 -36.391 15.613 -9.520 1.00 47.58 O ATOM 595 CB TYR A 112 -39.492 15.037 -9.636 1.00 46.85 C ATOM 596 CG TYR A 112 -40.854 15.656 -9.788 1.00 45.17 C ATOM 597 CD1 TYR A 112 -41.033 16.798 -10.544 1.00 46.22 C ATOM 598 CD2 TYR A 112 -41.950 15.128 -9.125 1.00 47.18 C ATOM 599 CE1 TYR A 112 -42.277 17.397 -10.653 1.00 46.03 C ATOM 600 CE2 TYR A 112 -43.190 15.722 -9.217 1.00 47.44 C ATOM 601 CZ TYR A 112 -43.351 16.850 -9.987 1.00 46.96 C ATOM 602 OH TYR A 112 -44.601 17.446 -10.054 1.00 53.89 O ATOM 603 N THR A 113 -36.875 14.681 -7.537 1.00 46.47 N ATOM 604 CA THR A 113 -35.517 14.235 -7.306 1.00 49.38 C ATOM 605 C THR A 113 -35.565 12.765 -6.969 1.00 47.52 C ATOM 606 O THR A 113 -36.439 12.326 -6.219 1.00 53.27 O ATOM 607 CB THR A 113 -34.880 15.009 -6.153 1.00 49.13 C ATOM 608 OG1 THR A 113 -35.283 16.378 -6.233 1.00 44.59 O ATOM 609 CG2 THR A 113 -33.384 14.935 -6.257 1.00 55.10 C ATOM 610 N CYS A 114 -34.673 11.988 -7.547 1.00 45.50 N ATOM 611 CA CYS A 114 -34.672 10.587 -7.245 1.00 52.63 C ATOM 612 C CYS A 114 -33.459 10.315 -6.398 1.00 51.30 C ATOM 613 O CYS A 114 -32.349 10.738 -6.724 1.00 51.19 O ATOM 614 CB CYS A 114 -34.717 9.720 -8.511 1.00 58.72 C ATOM 615 SG CYS A 114 -33.156 9.373 -9.335 1.00 69.59 S ATOM 616 N VAL A 115 -33.664 9.594 -5.311 1.00 45.50 N ATOM 617 CA VAL A 115 -32.589 9.347 -4.402 1.00 46.47 C ATOM 618 C VAL A 115 -32.166 7.888 -4.343 1.00 43.89 C ATOM 619 O VAL A 115 -32.989 7.004 -4.081 1.00 39.20 O ATOM 620 CB VAL A 115 -33.008 9.816 -3.020 1.00 51.24 C ATOM 621 CG1 VAL A 115 -31.892 9.556 -2.021 1.00 48.53 C ATOM 622 CG2 VAL A 115 -33.404 11.296 -3.102 1.00 51.41 C ATOM 623 N GLY A 116 -30.868 7.660 -4.589 1.00 45.18 N ATOM 624 CA GLY A 116 -30.260 6.319 -4.539 1.00 45.31 C ATOM 625 C GLY A 116 -29.448 6.061 -3.285 1.00 45.35 C ATOM 626 O GLY A 116 -28.630 6.884 -2.862 1.00 46.83 O ATOM 627 N ARG A 117 -29.676 4.919 -2.679 1.00 46.40 N ATOM 628 CA ARG A 117 -28.975 4.539 -1.460 1.00 48.51 C ATOM 629 C ARG A 117 -28.505 3.101 -1.592 1.00 50.83 C ATOM 630 O ARG A 117 -29.189 2.258 -2.174 1.00 51.28 O ATOM 631 CB ARG A 117 -29.903 4.655 -0.246 1.00 50.16 C ATOM 632 CG ARG A 117 -30.028 6.065 0.311 1.00 53.34 C ATOM 633 CD ARG A 117 -31.051 6.131 1.426 1.00 55.92 C ATOM 634 NE ARG A 117 -31.752 7.411 1.429 1.00 62.99 N ATOM 635 CZ ARG A 117 -33.036 7.593 1.105 1.00 74.85 C ATOM 636 NH1 ARG A 117 -33.824 6.571 0.772 1.00 77.70 N ATOM 637 NH2 ARG A 117 -33.539 8.821 1.134 1.00 84.49 N ATOM 638 N THR A 118 -27.321 2.828 -1.072 1.00 54.18 N ATOM 639 CA THR A 118 -26.859 1.458 -0.881 1.00 55.68 C ATOM 640 C THR A 118 -25.643 1.580 -0.005 1.00 58.96 C ATOM 641 O THR A 118 -24.861 2.538 -0.163 1.00 52.43 O ATOM 642 CB THR A 118 -26.507 0.705 -2.200 1.00 57.51 C ATOM 643 OG1 THR A 118 -26.434 -0.698 -1.933 1.00 63.01 O ATOM 644 CG2 THR A 118 -25.187 1.156 -2.816 1.00 52.40 C ATOM 645 N GLY A 119 -25.500 0.635 0.926 1.00 62.08 N ATOM 646 CA GLY A 119 -24.417 0.665 1.906 1.00 62.23 C ATOM 647 C GLY A 119 -24.332 2.025 2.553 1.00 61.41 C ATOM 648 O GLY A 119 -25.330 2.535 3.064 1.00 57.36 O ATOM 649 N SER A 120 -23.156 2.635 2.462 1.00 64.12 N ATOM 650 CA SER A 120 -22.912 3.939 3.053 1.00 64.13 C ATOM 651 C SER A 120 -23.057 5.077 2.059 1.00 65.01 C ATOM 652 O SER A 120 -22.798 6.219 2.403 1.00 69.70 O ATOM 653 CB SER A 120 -21.491 3.970 3.620 1.00 68.48 C ATOM 654 OG SER A 120 -20.538 4.172 2.582 1.00 69.99 O ATOM 655 N LYS A 121 -23.454 4.782 0.827 1.00 70.04 N ATOM 656 CA LYS A 121 -23.467 5.805 -0.213 1.00 66.97 C ATOM 657 C LYS A 121 -24.866 6.323 -0.522 1.00 60.63 C ATOM 658 O LYS A 121 -25.847 5.576 -0.471 1.00 55.59 O ATOM 659 CB LYS A 121 -22.802 5.280 -1.489 1.00 68.76 C ATOM 660 CG LYS A 121 -21.371 5.773 -1.690 1.00 76.66 C ATOM 661 CD LYS A 121 -20.310 4.697 -1.458 1.00 83.46 C ATOM 662 CE LYS A 121 -19.271 5.089 -0.400 1.00 88.02 C ATOM 663 NZ LYS A 121 -18.370 6.216 -0.780 1.00 88.65 N ATOM 664 N THR A 122 -24.935 7.613 -0.838 1.00 58.73 N ATOM 665 CA THR A 122 -26.161 8.243 -1.308 1.00 59.02 C ATOM 666 C THR A 122 -25.903 9.148 -2.523 1.00 58.31 C ATOM 667 O THR A 122 -25.002 9.968 -2.502 1.00 57.32 O ATOM 668 CB THR A 122 -26.793 9.080 -0.193 1.00 64.40 C ATOM 669 OG1 THR A 122 -26.844 8.307 1.014 1.00 67.34 O ATOM 670 CG2 THR A 122 -28.209 9.526 -0.587 1.00 69.52 C ATOM 671 N ILE A 123 -26.690 8.994 -3.583 1.00 57.34 N ATOM 672 CA ILE A 123 -26.612 9.901 -4.742 1.00 56.72 C ATOM 673 C ILE A 123 -28.002 10.374 -5.153 1.00 51.73 C ATOM 674 O ILE A 123 -28.998 9.813 -4.700 1.00 46.58 O ATOM 675 CB ILE A 123 -25.932 9.223 -5.946 1.00 61.16 C ATOM 676 CG1 ILE A 123 -26.830 8.127 -6.516 1.00 61.82 C ATOM 677 CG2 ILE A 123 -24.591 8.631 -5.536 1.00 59.95 C ATOM 678 CD1 ILE A 123 -26.209 7.350 -7.635 1.00 59.49 C ATOM 679 N TYR A 124 -28.062 11.403 -6.006 1.00 53.96 N ATOM 680 CA TYR A 124 -29.343 11.958 -6.486 1.00 52.03 C ATOM 681 C TYR A 124 -29.259 12.831 -7.744 1.00 52.51 C ATOM 682 O TYR A 124 -28.253 13.452 -8.043 1.00 44.95 O ATOM 683 CB TYR A 124 -30.017 12.746 -5.381 1.00 54.95 C ATOM 684 CG TYR A 124 -29.091 13.728 -4.734 1.00 64.70 C ATOM 685 CD1 TYR A 124 -28.259 13.337 -3.690 1.00 73.37 C ATOM 686 CD2 TYR A 124 -29.026 15.038 -5.176 1.00 67.65 C ATOM 687 CE1 TYR A 124 -27.392 14.234 -3.103 1.00 77.20 C ATOM 688 CE2 TYR A 124 -28.169 15.943 -4.590 1.00 75.70 C ATOM 689 CZ TYR A 124 -27.357 15.535 -3.554 1.00 77.52 C ATOM 690 OH TYR A 124 -26.504 16.431 -2.972 1.00 85.67 O ATOM 691 N ALA A 125 -30.360 12.850 -8.485 1.00 59.86 N ATOM 692 CA ALA A 125 -30.503 13.674 -9.691 1.00 63.30 C ATOM 693 C ALA A 125 -31.848 14.412 -9.641 1.00 66.05 C ATOM 694 O ALA A 125 -32.885 13.810 -9.325 1.00 59.52 O ATOM 695 CB ALA A 125 -30.427 12.798 -10.928 1.00 59.41 C ATOM 696 N SER A 126 -31.848 15.711 -9.932 1.00 63.35 N ATOM 697 CA SER A 126 -33.087 16.472 -9.806 1.00 63.07 C ATOM 698 C SER A 126 -33.542 16.908 -11.169 1.00 62.56 C ATOM 699 O SER A 126 -32.729 17.143 -12.056 1.00 74.64 O ATOM 700 CB SER A 126 -32.882 17.673 -8.918 1.00 59.22 C ATOM 701 OG SER A 126 -31.816 17.414 -8.036 1.00 64.39 O ATOM 702 N THR A 127 -34.848 17.012 -11.337 1.00 61.62 N ATOM 703 CA THR A 127 -35.404 17.542 -12.560 1.00 65.40 C ATOM 704 C THR A 127 -36.410 18.615 -12.233 1.00 63.41 C ATOM 705 O THR A 127 -37.294 18.412 -11.409 1.00 61.86 O ATOM 706 CB THR A 127 -36.132 16.451 -13.349 1.00 68.01 C ATOM 707 OG1 THR A 127 -35.371 15.249 -13.271 1.00 72.13 O ATOM 708 CG2 THR A 127 -36.324 16.859 -14.819 1.00 71.88 C ATOM 709 N VAL A 128 -36.286 19.754 -12.892 1.00 64.39 N ATOM 710 CA VAL A 128 -37.322 20.769 -12.825 1.00 61.43 C ATOM 711 C VAL A 128 -38.295 20.535 -13.963 1.00 54.25 C ATOM 712 O VAL A 128 -37.897 20.430 -15.115 1.00 48.90 O ATOM 713 CB VAL A 128 -36.724 22.156 -12.966 1.00 60.91 C ATOM 714 CG1 VAL A 128 -37.796 23.188 -12.696 1.00 68.71 C ATOM 715 CG2 VAL A 128 -35.575 22.310 -11.981 1.00 62.33 C ATOM 716 N VAL A 129 -39.565 20.419 -13.646 1.00 48.89 N ATOM 717 CA VAL A 129 -40.563 20.346 -14.690 1.00 54.66 C ATOM 718 C VAL A 129 -41.314 21.675 -14.766 1.00 58.81 C ATOM 719 O VAL A 129 -41.686 22.260 -13.738 1.00 57.93 O ATOM 720 CB VAL A 129 -41.537 19.194 -14.434 1.00 55.44 C ATOM 721 CG1 VAL A 129 -42.714 19.233 -15.395 1.00 52.40 C ATOM 722 CG2 VAL A 129 -40.783 17.884 -14.540 1.00 54.86 C ATOM 723 N HIS A 130 -41.543 22.131 -15.994 1.00 56.53 N ATOM 724 CA HIS A 130 -42.124 23.434 -16.235 1.00 55.55 C ATOM 725 C HIS A 130 -43.509 23.265 -16.774 1.00 54.30 C ATOM 726 O HIS A 130 -43.717 22.485 -17.694 1.00 60.66 O ATOM 727 CB HIS A 130 -41.278 24.205 -17.230 1.00 56.94 C ATOM 728 CG HIS A 130 -39.958 24.599 -16.682 1.00 57.62 C ATOM 729 ND1 HIS A 130 -39.761 25.784 -16.007 1.00 63.48 N ATOM 730 CD2 HIS A 130 -38.779 23.940 -16.641 1.00 63.38 C ATOM 731 CE1 HIS A 130 -38.512 25.847 -15.585 1.00 62.46 C ATOM 732 NE2 HIS A 130 -37.889 24.746 -15.968 1.00 67.37 N ATOM 733 N PRO A 131 -44.470 24.001 -16.206 1.00 55.00 N ATOM 734 CA PRO A 131 -45.871 23.882 -16.630 1.00 53.80 C ATOM 735 C PRO A 131 -46.088 24.416 -18.035 1.00 54.41 C ATOM 736 O PRO A 131 -45.262 25.156 -18.552 1.00 52.18 O ATOM 737 CB PRO A 131 -46.620 24.754 -15.625 1.00 52.06 C ATOM 738 CG PRO A 131 -45.598 25.795 -15.235 1.00 52.15 C ATOM 739 CD PRO A 131 -44.280 25.070 -15.208 1.00 53.07 C ATOM 740 N PRO A 132 -47.195 24.027 -18.660 1.00 63.41 N ATOM 741 CA PRO A 132 -47.517 24.626 -19.953 1.00 65.52 C ATOM 742 C PRO A 132 -47.743 26.137 -19.831 1.00 74.14 C ATOM 743 O PRO A 132 -48.084 26.651 -18.744 1.00 64.77 O ATOM 744 CB PRO A 132 -48.808 23.922 -20.355 1.00 64.38 C ATOM 745 CG PRO A 132 -48.787 22.626 -19.614 1.00 64.89 C ATOM 746 CD PRO A 132 -48.081 22.895 -18.321 1.00 63.66 C ATOM 747 N ARG A 133 -47.536 26.842 -20.940 1.00 76.97 N ATOM 748 CA ARG A 133 -47.762 28.281 -20.977 1.00 70.87 C ATOM 749 C ARG A 133 -49.244 28.505 -20.843 1.00 67.86 C ATOM 750 O ARG A 133 -49.679 29.413 -20.153 1.00 66.55 O ATOM 751 CB ARG A 133 -47.265 28.885 -22.281 1.00 72.34 C ATOM 752 N SER A 134 -50.012 27.657 -21.504 1.00 61.98 N ATOM 753 CA SER A 134 -51.446 27.726 -21.428 1.00 60.79 C ATOM 754 C SER A 134 -51.961 26.310 -21.358 1.00 61.79 C ATOM 755 O SER A 134 -51.311 25.391 -21.823 1.00 63.94 O ATOM 756 CB SER A 134 -52.010 28.443 -22.663 1.00 62.01 C ATOM 757 OG SER A 134 -52.278 27.527 -23.708 1.00 65.48 O ATOM 758 N SER A 135 -53.144 26.130 -20.794 1.00 68.48 N ATOM 759 CA SER A 135 -53.687 24.794 -20.617 1.00 66.38 C ATOM 760 C SER A 135 -55.208 24.739 -20.764 1.00 60.23 C ATOM 761 O SER A 135 -55.923 25.625 -20.341 1.00 64.20 O ATOM 762 CB SER A 135 -53.256 24.230 -19.247 1.00 65.54 C ATOM 763 OG SER A 135 -53.796 22.933 -19.044 1.00 62.12 O ATOM 764 N ARG A 136 -55.686 23.664 -21.346 1.00 60.73 N ATOM 765 CA ARG A 136 -57.102 23.450 -21.515 1.00 66.79 C ATOM 766 C ARG A 136 -57.674 22.725 -20.306 1.00 68.00 C ATOM 767 O ARG A 136 -58.866 22.780 -20.033 1.00 64.99 O ATOM 768 CB ARG A 136 -57.339 22.611 -22.775 1.00 77.66 C ATOM 769 CG ARG A 136 -58.111 23.326 -23.870 1.00 88.33 C ATOM 770 CD ARG A 136 -57.273 24.047 -24.922 1.00 88.19 C ATOM 771 NE ARG A 136 -57.972 25.241 -25.429 1.00 95.98 N ATOM 772 CZ ARG A 136 -59.166 25.247 -26.044 1.00 95.05 C ATOM 773 NH1 ARG A 136 -59.858 24.120 -26.256 1.00 87.27 N ATOM 774 NH2 ARG A 136 -59.688 26.401 -26.451 1.00 94.58 N ATOM 775 N LEU A 137 -56.812 22.034 -19.575 1.00 71.86 N ATOM 776 CA LEU A 137 -57.247 21.238 -18.448 1.00 69.79 C ATOM 777 C LEU A 137 -57.075 22.028 -17.173 1.00 65.11 C ATOM 778 O LEU A 137 -56.420 23.074 -17.150 1.00 63.77 O ATOM 779 CB LEU A 137 -56.417 19.975 -18.356 1.00 74.71 C ATOM 780 CG LEU A 137 -56.066 19.390 -19.721 1.00 81.55 C ATOM 781 CD1 LEU A 137 -55.419 18.035 -19.519 1.00 83.26 C ATOM 782 CD2 LEU A 137 -57.306 19.277 -20.602 1.00 85.53 C ATOM 783 N THR A 138 -57.634 21.502 -16.098 1.00 57.96 N ATOM 784 CA THR A 138 -57.489 22.142 -14.819 1.00 58.49 C ATOM 785 C THR A 138 -56.100 21.892 -14.284 1.00 60.14 C ATOM 786 O THR A 138 -55.575 20.790 -14.422 1.00 64.49 O ATOM 787 CB THR A 138 -58.475 21.603 -13.786 1.00 56.50 C ATOM 788 OG1 THR A 138 -59.685 21.234 -14.445 1.00 54.74 O ATOM 789 CG2 THR A 138 -58.750 22.662 -12.728 1.00 52.31 C ATOM 790 N PRO A 139 -55.500 22.912 -13.663 1.00 59.71 N ATOM 791 CA PRO A 139 -54.226 22.626 -13.074 1.00 62.36 C ATOM 792 C PRO A 139 -54.360 21.666 -11.913 1.00 63.33 C ATOM 793 O PRO A 139 -55.350 21.688 -11.196 1.00 64.97 O ATOM 794 CB PRO A 139 -53.750 23.994 -12.566 1.00 68.00 C ATOM 795 CG PRO A 139 -54.547 25.005 -13.322 1.00 65.90 C ATOM 796 CD PRO A 139 -55.863 24.335 -13.544 1.00 61.46 C ATOM 797 N GLU A 140 -53.348 20.821 -11.754 1.00 62.98 N ATOM 798 CA GLU A 140 -53.137 20.081 -10.535 1.00 57.00 C ATOM 799 C GLU A 140 -54.229 19.066 -10.243 1.00 58.82 C ATOM 800 O GLU A 140 -54.501 18.733 -9.089 1.00 58.37 O ATOM 801 CB GLU A 140 -52.975 21.059 -9.378 1.00 57.49 C ATOM 802 CG GLU A 140 -51.850 22.068 -9.590 1.00 61.72 C ATOM 803 CD GLU A 140 -50.451 21.450 -9.597 1.00 64.69 C ATOM 804 OE1 GLU A 140 -50.316 20.207 -9.716 1.00 68.77 O ATOM 805 OE2 GLU A 140 -49.474 22.226 -9.472 1.00 60.43 O ATOM 806 N LYS A 141 -54.853 18.555 -11.289 1.00 58.22 N ATOM 807 CA LYS A 141 -55.857 17.539 -11.101 1.00 61.89 C ATOM 808 C LYS A 141 -55.540 16.415 -12.044 1.00 63.58 C ATOM 809 O LYS A 141 -55.151 16.656 -13.182 1.00 63.44 O ATOM 810 CB LYS A 141 -57.262 18.077 -11.347 1.00 63.41 C ATOM 811 CG LYS A 141 -58.357 17.143 -10.880 1.00 60.51 C ATOM 812 N THR A 142 -55.722 15.194 -11.543 1.00 63.42 N ATOM 813 CA THR A 142 -55.211 13.996 -12.159 1.00 60.47 C ATOM 814 C THR A 142 -56.062 13.575 -13.333 1.00 58.99 C ATOM 815 O THR A 142 -57.258 13.354 -13.172 1.00 56.31 O ATOM 816 CB THR A 142 -55.197 12.836 -11.145 1.00 60.82 C ATOM 817 OG1 THR A 142 -54.607 13.276 -9.920 1.00 58.03 O ATOM 818 CG2 THR A 142 -54.396 11.672 -11.681 1.00 63.47 C ATOM 819 N TYR A 143 -55.434 13.431 -14.496 1.00 58.35 N ATOM 820 CA TYR A 143 -56.158 13.032 -15.695 1.00 62.91 C ATOM 821 C TYR A 143 -57.078 11.871 -15.367 1.00 65.92 C ATOM 822 O TYR A 143 -56.648 10.895 -14.773 1.00 72.07 O ATOM 823 CB TYR A 143 -55.209 12.608 -16.794 1.00 57.63 C ATOM 824 CG TYR A 143 -54.086 13.562 -17.031 1.00 54.52 C ATOM 825 CD1 TYR A 143 -54.329 14.913 -17.126 1.00 53.91 C ATOM 826 CD2 TYR A 143 -52.765 13.111 -17.158 1.00 53.13 C ATOM 827 CE1 TYR A 143 -53.298 15.808 -17.360 1.00 51.31 C ATOM 828 CE2 TYR A 143 -51.723 13.998 -17.391 1.00 50.94 C ATOM 829 CZ TYR A 143 -51.999 15.347 -17.493 1.00 51.25 C ATOM 830 OH TYR A 143 -50.990 16.257 -17.732 1.00 52.03 O ATOM 831 N PRO A 144 -58.350 11.971 -15.749 1.00 73.70 N ATOM 832 CA PRO A 144 -59.301 10.987 -15.272 1.00 72.87 C ATOM 833 C PRO A 144 -59.387 9.813 -16.237 1.00 68.62 C ATOM 834 O PRO A 144 -58.810 9.850 -17.324 1.00 71.93 O ATOM 835 CB PRO A 144 -60.605 11.778 -15.260 1.00 79.72 C ATOM 836 CG PRO A 144 -60.442 12.782 -16.379 1.00 81.97 C ATOM 837 CD PRO A 144 -58.971 12.876 -16.731 1.00 76.33 C ATOM 838 N GLY A 145 -60.112 8.784 -15.834 1.00 63.94 N ATOM 839 CA GLY A 145 -60.253 7.592 -16.635 1.00 66.57 C ATOM 840 C GLY A 145 -59.327 6.481 -16.196 1.00 72.74 C ATOM 841 O GLY A 145 -58.568 6.615 -15.236 1.00 76.08 O ATOM 842 N ALA A 146 -59.402 5.365 -16.901 1.00 68.17 N ATOM 843 CA ALA A 146 -58.514 4.279 -16.648 1.00 66.62 C ATOM 844 C ALA A 146 -57.122 4.742 -17.085 1.00 70.41 C ATOM 845 O ALA A 146 -56.975 5.827 -17.670 1.00 63.24 O ATOM 846 CB ALA A 146 -58.956 3.062 -17.440 1.00 68.77 C ATOM 847 N GLN A 147 -56.109 3.932 -16.778 1.00 67.00 N ATOM 848 CA GLN A 147 -54.757 4.195 -17.238 1.00 61.09 C ATOM 849 C GLN A 147 -54.010 2.925 -17.451 1.00 50.66 C ATOM 850 O GLN A 147 -54.060 2.023 -16.624 1.00 53.53 O ATOM 851 CB GLN A 147 -53.990 5.089 -16.256 1.00 65.32 C ATOM 852 CG GLN A 147 -54.447 5.009 -14.812 1.00 68.67 C ATOM 853 CD GLN A 147 -54.015 6.213 -13.988 1.00 72.61 C ATOM 854 OE1 GLN A 147 -54.460 6.411 -12.846 1.00 70.10 O ATOM 855 NE2 GLN A 147 -53.142 7.031 -14.566 1.00 73.67 N ATOM 856 N LYS A 148 -53.289 2.864 -18.558 1.00 49.04 N ATOM 857 CA LYS A 148 -52.503 1.688 -18.878 1.00 53.07 C ATOM 858 C LYS A 148 -51.518 1.472 -17.739 1.00 51.88 C ATOM 859 O LYS A 148 -50.954 2.433 -17.226 1.00 58.35 O ATOM 860 CB LYS A 148 -51.728 1.855 -20.198 1.00 54.89 C ATOM 861 CG LYS A 148 -52.389 1.153 -21.373 1.00 62.73 C ATOM 862 CD LYS A 148 -51.382 0.722 -22.437 1.00 63.95 C ATOM 863 N PRO A 149 -51.291 0.224 -17.343 1.00 44.76 N ATOM 864 CA PRO A 149 -50.242 0.083 -16.369 1.00 47.55 C ATOM 865 C PRO A 149 -48.894 0.604 -16.826 1.00 50.37 C ATOM 866 O PRO A 149 -48.597 0.621 -18.020 1.00 45.29 O ATOM 867 CB PRO A 149 -50.134 -1.418 -16.194 1.00 50.76 C ATOM 868 CG PRO A 149 -51.486 -1.917 -16.592 1.00 52.87 C ATOM 869 CD PRO A 149 -51.809 -1.083 -17.768 1.00 49.13 C ATOM 870 N ARG A 150 -48.106 1.047 -15.850 1.00 51.61 N ATOM 871 CA ARG A 150 -46.733 1.419 -16.059 1.00 47.09 C ATOM 872 C ARG A 150 -45.936 0.852 -14.923 1.00 46.17 C ATOM 873 O ARG A 150 -46.236 1.060 -13.758 1.00 52.65 O ATOM 874 CB ARG A 150 -46.592 2.905 -16.072 1.00 46.19 C ATOM 875 CG ARG A 150 -47.123 3.542 -17.319 1.00 51.77 C ATOM 876 CD ARG A 150 -47.500 4.972 -16.998 1.00 61.31 C ATOM 877 NE ARG A 150 -46.945 5.914 -17.972 1.00 69.14 N ATOM 878 CZ ARG A 150 -47.653 6.649 -18.822 1.00 71.00 C ATOM 879 NH1 ARG A 150 -48.993 6.577 -18.858 1.00 75.28 N ATOM 880 NH2 ARG A 150 -47.005 7.463 -19.645 1.00 72.89 N ATOM 881 N ILE A 151 -44.909 0.113 -15.275 1.00 47.24 N ATOM 882 CA ILE A 151 -44.041 -0.485 -14.309 1.00 44.07 C ATOM 883 C ILE A 151 -43.064 0.567 -13.850 1.00 43.67 C ATOM 884 O ILE A 151 -42.225 1.024 -14.614 1.00 45.78 O ATOM 885 CB ILE A 151 -43.304 -1.657 -14.930 1.00 46.48 C ATOM 886 CG1 ILE A 151 -44.315 -2.733 -15.307 1.00 45.50 C ATOM 887 CG2 ILE A 151 -42.290 -2.221 -13.938 1.00 49.76 C ATOM 888 CD1 ILE A 151 -43.678 -3.903 -16.016 1.00 47.12 C ATOM 889 N ILE A 152 -43.161 0.951 -12.595 1.00 43.91 N ATOM 890 CA ILE A 152 -42.383 2.080 -12.117 1.00 41.45 C ATOM 891 C ILE A 152 -41.148 1.707 -11.344 1.00 40.43 C ATOM 892 O ILE A 152 -40.344 2.573 -11.043 1.00 48.42 O ATOM 893 CB ILE A 152 -43.232 3.041 -11.272 1.00 42.31 C ATOM 894 CG1 ILE A 152 -44.101 2.272 -10.268 1.00 46.40 C ATOM 895 CG2 ILE A 152 -44.097 3.886 -12.197 1.00 45.89 C ATOM 896 CD1 ILE A 152 -44.525 3.107 -9.084 1.00 47.99 C ATOM 897 N TYR A 153 -40.978 0.447 -10.986 1.00 40.68 N ATOM 898 CA TYR A 153 -39.804 0.073 -10.199 1.00 38.87 C ATOM 899 C TYR A 153 -39.429 -1.305 -10.617 1.00 35.01 C ATOM 900 O TYR A 153 -40.254 -2.194 -10.577 1.00 35.29 O ATOM 901 CB TYR A 153 -40.135 0.070 -8.707 1.00 42.06 C ATOM 902 CG TYR A 153 -38.916 0.107 -7.823 1.00 44.29 C ATOM 903 CD1 TYR A 153 -38.170 -1.034 -7.582 1.00 45.46 C ATOM 904 CD2 TYR A 153 -38.498 1.284 -7.245 1.00 47.16 C ATOM 905 CE1 TYR A 153 -37.046 -0.988 -6.811 1.00 42.37 C ATOM 906 CE2 TYR A 153 -37.374 1.324 -6.447 1.00 45.12 C ATOM 907 CZ TYR A 153 -36.669 0.180 -6.257 1.00 41.76 C ATOM 908 OH TYR A 153 -35.577 0.206 -5.488 1.00 43.57 O ATOM 909 N THR A 154 -38.200 -1.501 -11.032 1.00 36.29 N ATOM 910 CA THR A 154 -37.831 -2.768 -11.633 1.00 43.50 C ATOM 911 C THR A 154 -36.346 -2.869 -11.671 1.00 41.16 C ATOM 912 O THR A 154 -35.675 -1.859 -11.721 1.00 42.67 O ATOM 913 CB THR A 154 -38.345 -2.889 -13.077 1.00 47.87 C ATOM 914 OG1 THR A 154 -37.664 -3.972 -13.716 1.00 53.83 O ATOM 915 CG2 THR A 154 -38.086 -1.613 -13.863 1.00 45.79 C ATOM 916 N GLU A 155 -35.843 -4.087 -11.622 1.00 43.54 N ATOM 917 CA GLU A 155 -34.408 -4.326 -11.711 1.00 47.54 C ATOM 918 C GLU A 155 -34.056 -4.745 -13.138 1.00 46.24 C ATOM 919 O GLU A 155 -34.677 -5.653 -13.710 1.00 42.01 O ATOM 920 CB GLU A 155 -33.963 -5.406 -10.710 1.00 50.38 C ATOM 921 CG GLU A 155 -34.103 -4.953 -9.276 1.00 59.40 C ATOM 922 CD GLU A 155 -33.636 -5.971 -8.257 1.00 65.21 C ATOM 923 OE1 GLU A 155 -33.320 -7.112 -8.678 1.00 70.30 O ATOM 924 OE2 GLU A 155 -33.584 -5.618 -7.040 1.00 63.42 O ATOM 925 N LYS A 156 -33.043 -4.091 -13.690 1.00 42.10 N ATOM 926 CA LYS A 156 -32.530 -4.424 -14.992 1.00 45.08 C ATOM 927 C LYS A 156 -31.533 -5.579 -14.938 1.00 43.87 C ATOM 928 O LYS A 156 -31.645 -6.522 -15.691 1.00 44.48 O ATOM 929 CB LYS A 156 -31.848 -3.194 -15.583 1.00 49.83 C ATOM 930 CG LYS A 156 -32.790 -2.036 -15.886 1.00 51.69 C ATOM 931 CD LYS A 156 -33.721 -2.373 -17.039 1.00 55.88 C ATOM 932 CE LYS A 156 -33.023 -2.250 -18.384 1.00 58.33 C ATOM 933 NZ LYS A 156 -33.422 -3.369 -19.282 1.00 61.03 N ATOM 934 N THR A 157 -30.554 -5.487 -14.054 1.00 40.86 N ATOM 935 CA THR A 157 -29.528 -6.488 -13.922 1.00 43.80 C ATOM 936 C THR A 157 -29.438 -6.894 -12.483 1.00 42.89 C ATOM 937 O THR A 157 -29.341 -6.045 -11.638 1.00 50.37 O ATOM 938 CB THR A 157 -28.178 -5.896 -14.264 1.00 44.89 C ATOM 939 OG1 THR A 157 -28.243 -5.323 -15.568 1.00 56.47 O ATOM 940 CG2 THR A 157 -27.102 -6.940 -14.215 1.00 46.19 C ATOM 941 N HIS A 158 -29.439 -8.182 -12.201 1.00 40.62 N ATOM 942 CA HIS A 158 -29.262 -8.657 -10.834 1.00 43.12 C ATOM 943 C HIS A 158 -28.335 -9.858 -10.787 1.00 43.87 C ATOM 944 O HIS A 158 -28.759 -10.975 -11.074 1.00 38.35 O ATOM 945 CB HIS A 158 -30.581 -9.066 -10.211 1.00 41.82 C ATOM 946 CG HIS A 158 -30.479 -9.336 -8.745 1.00 46.33 C ATOM 947 ND1 HIS A 158 -31.362 -8.803 -7.824 1.00 49.95 N ATOM 948 CD2 HIS A 158 -29.585 -10.061 -8.031 1.00 46.86 C ATOM 949 CE1 HIS A 158 -31.028 -9.206 -6.611 1.00 49.06 C ATOM 950 NE2 HIS A 158 -29.958 -9.977 -6.710 1.00 50.26 N ATOM 951 N LEU A 159 -27.088 -9.617 -10.385 1.00 43.07 N ATOM 952 CA LEU A 159 -26.081 -10.641 -10.299 1.00 44.85 C ATOM 953 C LEU A 159 -25.829 -11.016 -8.827 1.00 52.63 C ATOM 954 O LEU A 159 -25.551 -10.155 -7.994 1.00 53.81 O ATOM 955 CB LEU A 159 -24.822 -10.090 -10.932 1.00 43.44 C ATOM 956 CG LEU A 159 -23.601 -10.935 -10.610 1.00 46.49 C ATOM 957 N ASP A 160 -25.938 -12.294 -8.488 1.00 59.86 N ATOM 958 CA ASP A 160 -25.620 -12.739 -7.128 1.00 60.14 C ATOM 959 C ASP A 160 -24.984 -14.121 -7.131 1.00 59.88 C ATOM 960 O ASP A 160 -24.974 -14.807 -8.155 1.00 57.50 O ATOM 961 CB ASP A 160 -26.881 -12.752 -6.267 1.00 61.60 C ATOM 962 CG ASP A 160 -26.603 -12.416 -4.801 1.00 63.19 C ATOM 963 OD1 ASP A 160 -25.467 -12.631 -4.327 1.00 58.17 O ATOM 964 OD2 ASP A 160 -27.534 -11.915 -4.122 1.00 71.36 O ATOM 965 N LEU A 161 -24.453 -14.510 -5.974 1.00 64.92 N ATOM 966 CA LEU A 161 -23.756 -15.778 -5.800 1.00 64.23 C ATOM 967 C LEU A 161 -24.666 -16.969 -5.910 1.00 65.47 C ATOM 968 O LEU A 161 -25.837 -16.917 -5.571 1.00 68.49 O ATOM 969 CB LEU A 161 -23.090 -15.828 -4.436 1.00 67.89 C ATOM 970 CG LEU A 161 -22.048 -14.726 -4.268 1.00 74.84 C ATOM 971 CD1 LEU A 161 -21.672 -14.592 -2.796 1.00 77.18 C ATOM 972 CD2 LEU A 161 -20.827 -14.991 -5.161 1.00 73.37 C ATOM 973 N MET A 162 -24.099 -18.067 -6.366 1.00 73.57 N ATOM 974 CA MET A 162 -24.843 -19.292 -6.465 1.00 77.34 C ATOM 975 C MET A 162 -25.463 -19.634 -5.122 1.00 73.29 C ATOM 976 CB MET A 162 -23.938 -20.443 -6.891 1.00 81.63 C ATOM 977 CG MET A 162 -24.592 -21.388 -7.879 1.00 87.30 C ATOM 978 SD MET A 162 -24.093 -20.953 -9.558 1.00 91.04 S ATOM 979 CE MET A 162 -25.730 -20.808 -10.233 1.00 82.04 C ATOM 980 N GLY A 163 -26.683 -20.140 -5.236 1.00 75.32 N ATOM 981 CA GLY A 163 -27.412 -20.655 -4.100 1.00 73.19 C ATOM 982 C GLY A 163 -28.033 -19.559 -3.283 1.00 67.98 C ATOM 983 O GLY A 163 -28.742 -19.842 -2.321 1.00 72.59 O ATOM 984 N SER A 164 -27.799 -18.306 -3.665 1.00 62.64 N ATOM 985 CA SER A 164 -28.320 -17.211 -2.877 1.00 62.30 C ATOM 986 C SER A 164 -29.778 -17.012 -3.284 1.00 60.40 C ATOM 987 O SER A 164 -30.296 -17.770 -4.102 1.00 62.36 O ATOM 988 CB SER A 164 -27.485 -15.953 -3.032 1.00 57.92 C ATOM 989 OG SER A 164 -28.025 -15.154 -4.023 1.00 59.13 O ATOM 990 N ASN A 165 -30.464 -16.069 -2.654 1.00 60.00 N ATOM 991 CA ASN A 165 -31.860 -15.799 -2.994 1.00 60.92 C ATOM 992 C ASN A 165 -31.988 -14.415 -3.530 1.00 55.00 C ATOM 993 O ASN A 165 -31.260 -13.513 -3.146 1.00 55.79 O ATOM 994 CB ASN A 165 -32.776 -15.920 -1.784 1.00 66.19 C ATOM 995 CG ASN A 165 -32.521 -17.171 -0.998 1.00 65.53 C ATOM 996 OD1 ASN A 165 -32.389 -18.253 -1.555 1.00 72.45 O ATOM 997 ND2 ASN A 165 -32.428 -17.025 0.302 1.00 67.38 N ATOM 998 N ILE A 166 -32.926 -14.230 -4.432 1.00 51.28 N ATOM 999 CA ILE A 166 -33.088 -12.932 -5.005 1.00 44.49 C ATOM 1000 C ILE A 166 -34.559 -12.672 -5.133 1.00 42.13 C ATOM 1001 O ILE A 166 -35.358 -13.591 -5.308 1.00 43.80 O ATOM 1002 CB ILE A 166 -32.356 -12.862 -6.353 1.00 47.74 C ATOM 1003 CG1 ILE A 166 -33.100 -13.609 -7.441 1.00 48.36 C ATOM 1004 CG2 ILE A 166 -30.979 -13.504 -6.249 1.00 49.82 C ATOM 1005 CD1 ILE A 166 -32.402 -13.498 -8.777 1.00 49.84 C ATOM 1006 N GLN A 167 -34.907 -11.406 -5.062 1.00 45.36 N ATOM 1007 CA GLN A 167 -36.292 -10.987 -5.007 1.00 48.09 C ATOM 1008 C GLN A 167 -36.394 -9.871 -5.998 1.00 44.47 C ATOM 1009 O GLN A 167 -35.913 -8.780 -5.729 1.00 42.81 O ATOM 1010 CB GLN A 167 -36.619 -10.467 -3.603 1.00 50.56 C ATOM 1011 CG GLN A 167 -38.095 -10.513 -3.274 1.00 54.69 C ATOM 1012 CD GLN A 167 -38.383 -10.124 -1.830 1.00 53.77 C ATOM 1013 OE1 GLN A 167 -37.707 -10.573 -0.874 1.00 51.64 O ATOM 1014 NE2 GLN A 167 -39.390 -9.285 -1.664 1.00 51.66 N ATOM 1015 N LEU A 168 -36.997 -10.139 -7.156 1.00 43.73 N ATOM 1016 CA LEU A 168 -37.009 -9.172 -8.263 1.00 35.14 C ATOM 1017 C LEU A 168 -38.301 -8.408 -8.222 1.00 32.72 C ATOM 1018 O LEU A 168 -39.355 -9.013 -8.230 1.00 37.74 O ATOM 1019 CB LEU A 168 -36.959 -9.897 -9.580 1.00 37.54 C ATOM 1020 CG LEU A 168 -35.915 -10.980 -9.722 1.00 43.30 C ATOM 1021 CD1 LEU A 168 -36.153 -11.658 -11.057 1.00 45.84 C ATOM 1022 CD2 LEU A 168 -34.510 -10.395 -9.618 1.00 46.98 C ATOM 1023 N PRO A 169 -38.243 -7.077 -8.153 1.00 32.08 N ATOM 1024 CA PRO A 169 -39.480 -6.376 -8.053 1.00 32.89 C ATOM 1025 C PRO A 169 -40.127 -6.071 -9.380 1.00 38.39 C ATOM 1026 O PRO A 169 -39.528 -6.246 -10.469 1.00 41.98 O ATOM 1027 CB PRO A 169 -39.065 -5.058 -7.417 1.00 32.33 C ATOM 1028 CG PRO A 169 -37.761 -4.784 -8.037 1.00 33.63 C ATOM 1029 CD PRO A 169 -37.102 -6.143 -8.042 1.00 34.36 C ATOM 1030 N CYS A 170 -41.375 -5.636 -9.240 1.00 42.32 N ATOM 1031 CA CYS A 170 -42.172 -5.056 -10.291 1.00 40.94 C ATOM 1032 C CYS A 170 -43.190 -4.217 -9.532 1.00 43.30 C ATOM 1033 O CYS A 170 -44.009 -4.748 -8.792 1.00 45.60 O ATOM 1034 CB CYS A 170 -42.863 -6.168 -11.044 1.00 43.54 C ATOM 1035 SG CYS A 170 -43.592 -5.701 -12.624 1.00 49.96 S ATOM 1036 N ARG A 171 -43.106 -2.908 -9.650 1.00 41.35 N ATOM 1037 CA ARG A 171 -44.130 -2.067 -9.094 1.00 43.12 C ATOM 1038 C ARG A 171 -44.737 -1.290 -10.213 1.00 40.00 C ATOM 1039 O ARG A 171 -44.098 -1.015 -11.228 1.00 37.49 O ATOM 1040 CB ARG A 171 -43.535 -1.081 -8.116 1.00 51.52 C ATOM 1041 CG ARG A 171 -42.489 -1.660 -7.205 1.00 58.63 C ATOM 1042 CD ARG A 171 -43.088 -2.064 -5.877 1.00 64.27 C ATOM 1043 NE ARG A 171 -42.205 -3.012 -5.214 1.00 62.13 N ATOM 1044 CZ ARG A 171 -41.082 -2.694 -4.594 1.00 58.26 C ATOM 1045 NH1 ARG A 171 -40.662 -1.425 -4.536 1.00 56.97 N ATOM 1046 NH2 ARG A 171 -40.372 -3.675 -4.039 1.00 61.35 N ATOM 1047 N VAL A 172 -45.932 -0.824 -9.968 1.00 41.09 N ATOM 1048 CA VAL A 172 -46.783 -0.404 -11.023 1.00 42.04 C ATOM 1049 C VAL A 172 -47.582 0.801 -10.645 1.00 43.37 C ATOM 1050 O VAL A 172 -47.900 1.057 -9.474 1.00 44.24 O ATOM 1051 CB VAL A 172 -47.774 -1.547 -11.311 1.00 49.26 C ATOM 1052 CG1 VAL A 172 -48.833 -1.128 -12.310 1.00 54.32 C ATOM 1053 CG2 VAL A 172 -47.014 -2.782 -11.810 1.00 49.83 C ATOM 1054 N HIS A 173 -47.914 1.550 -11.673 1.00 49.32 N ATOM 1055 CA HIS A 173 -48.874 2.610 -11.596 1.00 53.31 C ATOM 1056 C HIS A 173 -49.962 2.207 -12.552 1.00 54.17 C ATOM 1057 O HIS A 173 -49.707 2.023 -13.714 1.00 55.60 O ATOM 1058 CB HIS A 173 -48.227 3.888 -12.065 1.00 58.98 C ATOM 1059 CG HIS A 173 -48.990 5.111 -11.696 1.00 63.78 C ATOM 1060 ND1 HIS A 173 -48.895 5.697 -10.451 1.00 62.30 N ATOM 1061 CD2 HIS A 173 -49.854 5.867 -12.411 1.00 62.72 C ATOM 1062 CE1 HIS A 173 -49.671 6.763 -10.415 1.00 63.48 C ATOM 1063 NE2 HIS A 173 -50.262 6.888 -11.591 1.00 63.16 N ATOM 1064 N ALA A 174 -51.178 2.049 -12.062 1.00 60.44 N ATOM 1065 CA ALA A 174 -52.236 1.567 -12.902 1.00 58.09 C ATOM 1066 C ALA A 174 -53.552 1.817 -12.251 1.00 61.63 C ATOM 1067 O ALA A 174 -53.710 1.557 -11.064 1.00 63.41 O ATOM 1068 CB ALA A 174 -52.073 0.080 -13.136 1.00 62.83 C ATOM 1069 N ARG A 175 -54.498 2.297 -13.044 1.00 66.45 N ATOM 1070 CA ARG A 175 -55.891 2.384 -12.639 1.00 63.88 C ATOM 1071 C ARG A 175 -56.722 1.868 -13.830 1.00 59.86 C ATOM 1072 O ARG A 175 -56.658 2.522 -14.880 1.00 60.07 O ATOM 1073 CB ARG A 175 -56.262 3.826 -12.311 1.00 59.89 C ATOM 1074 CG ARG A 175 -57.652 3.971 -11.746 1.00 72.09 C ATOM 1075 CD ARG A 175 -57.800 5.249 -10.937 1.00 84.27 C ATOM 1076 NE ARG A 175 -59.031 5.955 -11.279 1.00 91.66 N ATOM 1077 CZ ARG A 175 -59.224 6.608 -12.424 1.00 97.97 C ATOM 1078 NH1 ARG A 175 -58.274 6.638 -13.350 1.00 98.36 N ATOM 1079 NH2 ARG A 175 -60.379 7.223 -12.654 1.00102.81 N ATOM 1080 N PRO A 176 -57.466 0.748 -13.687 1.00 48.93 N ATOM 1081 CA PRO A 176 -57.499 0.029 -12.415 1.00 53.59 C ATOM 1082 C PRO A 176 -56.208 -0.700 -12.087 1.00 57.25 C ATOM 1083 O PRO A 176 -55.312 -0.831 -12.915 1.00 57.87 O ATOM 1084 CB PRO A 176 -58.608 -1.030 -12.595 1.00 48.35 C ATOM 1085 CG PRO A 176 -59.318 -0.680 -13.836 1.00 50.23 C ATOM 1086 CD PRO A 176 -58.307 0.048 -14.680 1.00 51.50 C ATOM 1087 N ARG A 177 -56.172 -1.206 -10.865 1.00 62.53 N ATOM 1088 CA ARG A 177 -54.987 -1.849 -10.316 1.00 61.97 C ATOM 1089 C ARG A 177 -54.610 -3.012 -11.214 1.00 61.57 C ATOM 1090 O ARG A 177 -55.457 -3.545 -11.918 1.00 63.73 O ATOM 1091 CB ARG A 177 -55.214 -2.289 -8.870 1.00 58.21 C ATOM 1092 CG ARG A 177 -54.842 -1.186 -7.890 1.00 61.55 C ATOM 1093 CD ARG A 177 -55.478 -1.322 -6.511 1.00 65.99 C ATOM 1094 NE ARG A 177 -54.536 -1.760 -5.474 1.00 72.61 N ATOM 1095 CZ ARG A 177 -53.653 -0.972 -4.845 1.00 81.32 C ATOM 1096 NH1 ARG A 177 -53.544 0.323 -5.133 1.00 84.32 N ATOM 1097 NH2 ARG A 177 -52.855 -1.483 -3.914 1.00 78.31 N ATOM 1098 N ALA A 178 -53.333 -3.381 -11.218 1.00 55.62 N ATOM 1099 CA ALA A 178 -52.816 -4.226 -12.282 1.00 55.11 C ATOM 1100 C ALA A 178 -52.357 -5.563 -11.810 1.00 53.51 C ATOM 1101 O ALA A 178 -51.716 -5.641 -10.766 1.00 48.81 O ATOM 1102 CB ALA A 178 -51.676 -3.533 -12.991 1.00 58.79 C ATOM 1103 N GLU A 179 -52.639 -6.597 -12.615 1.00 49.50 N ATOM 1104 CA GLU A 179 -52.264 -7.960 -12.298 1.00 51.64 C ATOM 1105 C GLU A 179 -50.858 -8.179 -12.759 1.00 52.40 C ATOM 1106 O GLU A 179 -50.460 -7.669 -13.785 1.00 57.70 O ATOM 1107 CB GLU A 179 -53.143 -8.956 -13.024 1.00 59.69 C ATOM 1108 CG GLU A 179 -54.628 -8.718 -12.844 1.00 69.27 C ATOM 1109 CD GLU A 179 -55.163 -9.399 -11.603 1.00 76.35 C ATOM 1110 OE1 GLU A 179 -54.545 -9.242 -10.529 1.00 83.23 O ATOM 1111 OE2 GLU A 179 -56.193 -10.101 -11.709 1.00 86.95 O ATOM 1112 N ILE A 180 -50.112 -8.965 -12.009 1.00 48.31 N ATOM 1113 CA ILE A 180 -48.730 -9.196 -12.295 1.00 46.86 C ATOM 1114 C ILE A 180 -48.572 -10.658 -12.594 1.00 48.57 C ATOM 1115 O ILE A 180 -49.148 -11.493 -11.908 1.00 49.41 O ATOM 1116 CB ILE A 180 -47.817 -8.925 -11.075 1.00 46.08 C ATOM 1117 CG1 ILE A 180 -48.038 -7.542 -10.491 1.00 41.87 C ATOM 1118 CG2 ILE A 180 -46.365 -9.060 -11.496 1.00 46.49 C ATOM 1119 CD1 ILE A 180 -47.493 -6.420 -11.322 1.00 44.97 C ATOM 1120 N THR A 181 -47.781 -10.974 -13.612 1.00 53.88 N ATOM 1121 CA THR A 181 -47.448 -12.362 -13.932 1.00 50.32 C ATOM 1122 C THR A 181 -46.015 -12.332 -14.304 1.00 48.61 C ATOM 1123 O THR A 181 -45.512 -11.296 -14.743 1.00 57.12 O ATOM 1124 CB THR A 181 -48.259 -12.901 -15.121 1.00 52.54 C ATOM 1125 OG1 THR A 181 -49.606 -12.432 -15.044 1.00 51.13 O ATOM 1126 CG2 THR A 181 -48.298 -14.412 -15.095 1.00 56.86 C ATOM 1127 N TRP A 182 -45.321 -13.430 -14.085 1.00 44.94 N ATOM 1128 CA TRP A 182 -43.920 -13.457 -14.401 1.00 44.09 C ATOM 1129 C TRP A 182 -43.663 -14.566 -15.384 1.00 44.91 C ATOM 1130 O TRP A 182 -44.350 -15.562 -15.339 1.00 47.44 O ATOM 1131 CB TRP A 182 -43.127 -13.706 -13.147 1.00 46.07 C ATOM 1132 CG TRP A 182 -42.869 -12.499 -12.313 1.00 45.56 C ATOM 1133 CD1 TRP A 182 -43.636 -12.025 -11.288 1.00 44.64 C ATOM 1134 CD2 TRP A 182 -41.755 -11.644 -12.400 1.00 40.51 C ATOM 1135 NE1 TRP A 182 -43.075 -10.902 -10.755 1.00 39.70 N ATOM 1136 CE2 TRP A 182 -41.906 -10.656 -11.414 1.00 42.90 C ATOM 1137 CE3 TRP A 182 -40.646 -11.601 -13.221 1.00 43.98 C ATOM 1138 CZ2 TRP A 182 -40.975 -9.652 -11.222 1.00 44.08 C ATOM 1139 CZ3 TRP A 182 -39.722 -10.573 -13.043 1.00 43.69 C ATOM 1140 CH2 TRP A 182 -39.887 -9.630 -12.051 1.00 42.05 C ATOM 1141 N LEU A 183 -42.681 -14.408 -16.269 1.00 45.69 N ATOM 1142 CA LEU A 183 -42.222 -15.542 -17.072 1.00 47.64 C ATOM 1143 C LEU A 183 -40.789 -15.795 -16.733 1.00 47.32 C ATOM 1144 O LEU A 183 -40.113 -14.859 -16.315 1.00 48.00 O ATOM 1145 CB LEU A 183 -42.288 -15.227 -18.559 1.00 45.15 C ATOM 1146 CG LEU A 183 -43.486 -14.474 -19.098 1.00 42.86 C ATOM 1147 CD1 LEU A 183 -43.147 -14.252 -20.556 1.00 41.89 C ATOM 1148 CD2 LEU A 183 -44.810 -15.219 -18.972 1.00 43.97 C ATOM 1149 N ASN A 184 -40.310 -17.011 -16.974 1.00 46.59 N ATOM 1150 CA ASN A 184 -38.911 -17.350 -16.695 1.00 51.14 C ATOM 1151 C ASN A 184 -38.002 -17.130 -17.880 1.00 50.80 C ATOM 1152 O ASN A 184 -38.397 -16.502 -18.853 1.00 49.08 O ATOM 1153 CB ASN A 184 -38.799 -18.798 -16.197 1.00 56.11 C ATOM 1154 CG ASN A 184 -39.447 -19.785 -17.134 1.00 57.70 C ATOM 1155 OD1 ASN A 184 -40.016 -19.416 -18.158 1.00 54.95 O ATOM 1156 ND2 ASN A 184 -39.385 -21.045 -16.773 1.00 62.16 N ATOM 1157 N ASN A 185 -36.772 -17.628 -17.779 1.00 57.17 N ATOM 1158 CA ASN A 185 -35.795 -17.470 -18.857 1.00 66.20 C ATOM 1159 C ASN A 185 -36.240 -18.115 -20.149 1.00 68.31 C ATOM 1160 O ASN A 185 -35.956 -17.603 -21.217 1.00 76.26 O ATOM 1161 CB ASN A 185 -34.394 -17.970 -18.465 1.00 64.86 C ATOM 1162 CG ASN A 185 -34.433 -19.021 -17.392 1.00 67.09 C ATOM 1163 OD1 ASN A 185 -35.510 -19.429 -16.960 1.00 72.45 O ATOM 1164 ND2 ASN A 185 -33.268 -19.444 -16.927 1.00 66.28 N ATOM 1165 N GLU A 186 -36.929 -19.244 -20.055 1.00 70.87 N ATOM 1166 CA GLU A 186 -37.392 -19.952 -21.253 1.00 67.51 C ATOM 1167 C GLU A 186 -38.635 -19.272 -21.772 1.00 63.56 C ATOM 1168 O GLU A 186 -39.153 -19.625 -22.813 1.00 58.30 O ATOM 1169 CB GLU A 186 -37.690 -21.413 -20.951 1.00 70.63 C ATOM 1170 CG GLU A 186 -36.447 -22.280 -20.759 1.00 83.42 C ATOM 1171 CD GLU A 186 -35.287 -21.575 -20.047 1.00 91.27 C ATOM 1172 OE1 GLU A 186 -35.520 -20.572 -19.346 1.00106.75 O ATOM 1173 OE2 GLU A 186 -34.129 -22.030 -20.184 1.00 87.55 O ATOM 1174 N ASN A 187 -39.125 -18.290 -21.037 1.00 61.38 N ATOM 1175 CA ASN A 187 -40.340 -17.604 -21.417 1.00 64.54 C ATOM 1176 C ASN A 187 -41.643 -18.346 -21.115 1.00 64.29 C ATOM 1177 O ASN A 187 -42.698 -17.922 -21.569 1.00 66.25 O ATOM 1178 CB ASN A 187 -40.301 -17.228 -22.886 1.00 69.33 C ATOM 1179 CG ASN A 187 -40.613 -15.771 -23.102 1.00 78.46 C ATOM 1180 OD1 ASN A 187 -41.576 -15.435 -23.786 1.00 92.18 O ATOM 1181 ND2 ASN A 187 -39.805 -14.884 -22.496 1.00 76.98 N ATOM 1182 N LYS A 188 -41.570 -19.435 -20.348 1.00 62.63 N ATOM 1183 CA LYS A 188 -42.755 -20.038 -19.721 1.00 59.00 C ATOM 1184 C LYS A 188 -43.256 -19.199 -18.531 1.00 57.35 C ATOM 1185 O LYS A 188 -42.475 -18.558 -17.823 1.00 54.80 O ATOM 1186 CB LYS A 188 -42.449 -21.462 -19.235 1.00 55.60 C ATOM 1187 N GLU A 189 -44.568 -19.217 -18.315 1.00 59.45 N ATOM 1188 CA GLU A 189 -45.157 -18.550 -17.162 1.00 61.02 C ATOM 1189 C GLU A 189 -44.674 -19.239 -15.894 1.00 60.75 C ATOM 1190 O GLU A 189 -44.536 -20.448 -15.877 1.00 61.79 O ATOM 1191 CB GLU A 189 -46.680 -18.589 -17.229 1.00 62.86 C ATOM 1192 CG GLU A 189 -47.344 -18.236 -15.912 1.00 72.74 C ATOM 1193 CD GLU A 189 -48.748 -17.659 -16.060 1.00 83.91 C ATOM 1194 OE1 GLU A 189 -49.345 -17.756 -17.159 1.00 98.79 O ATOM 1195 OE2 GLU A 189 -49.267 -17.111 -15.060 1.00 85.58 O ATOM 1196 N ILE A 190 -44.417 -18.469 -14.842 1.00 59.83 N ATOM 1197 CA ILE A 190 -43.998 -19.027 -13.554 1.00 65.95 C ATOM 1198 C ILE A 190 -45.205 -19.268 -12.653 1.00 68.06 C ATOM 1199 O ILE A 190 -45.998 -18.347 -12.424 1.00 63.25 O ATOM 1200 CB ILE A 190 -43.071 -18.050 -12.815 1.00 66.98 C ATOM 1201 CG1 ILE A 190 -41.848 -17.765 -13.660 1.00 70.02 C ATOM 1202 CG2 ILE A 190 -42.667 -18.588 -11.456 1.00 68.93 C ATOM 1203 CD1 ILE A 190 -40.771 -16.983 -12.947 1.00 71.43 C ATOM 1204 N VAL A 191 -45.326 -20.489 -12.132 1.00 75.56 N ATOM 1205 CA VAL A 191 -46.327 -20.805 -11.094 1.00 77.60 C ATOM 1206 C VAL A 191 -45.618 -21.131 -9.789 1.00 73.50 C ATOM 1207 O VAL A 191 -44.433 -21.498 -9.781 1.00 75.95 O ATOM 1208 CB VAL A 191 -47.221 -22.001 -11.467 1.00 79.48 C ATOM 1209 CG1 VAL A 191 -47.994 -21.716 -12.747 1.00 79.66 C ATOM 1210 CG2 VAL A 191 -46.397 -23.282 -11.589 1.00 80.63 C ATOM 1211 N GLN A 192 -46.352 -21.018 -8.691 1.00 69.39 N ATOM 1212 CA GLN A 192 -45.753 -21.183 -7.373 1.00 70.14 C ATOM 1213 C GLN A 192 -45.069 -22.535 -7.281 1.00 63.93 C ATOM 1214 O GLN A 192 -45.587 -23.531 -7.778 1.00 64.49 O ATOM 1215 CB GLN A 192 -46.808 -21.067 -6.273 1.00 75.24 C ATOM 1216 CG GLN A 192 -46.440 -20.083 -5.185 1.00 79.59 C ATOM 1217 CD GLN A 192 -46.821 -20.561 -3.807 1.00 80.73 C ATOM 1218 OE1 GLN A 192 -45.957 -20.851 -2.979 1.00 83.19 O ATOM 1219 NE2 GLN A 192 -48.116 -20.653 -3.552 1.00 85.23 N ATOM 1220 N GLY A 193 -43.910 -22.567 -6.648 1.00 64.14 N ATOM 1221 CA GLY A 193 -43.141 -23.811 -6.524 1.00 66.93 C ATOM 1222 C GLY A 193 -42.028 -23.698 -5.495 1.00 64.51 C ATOM 1223 O GLY A 193 -41.858 -22.654 -4.885 1.00 67.10 O ATOM 1224 N HIS A 194 -41.263 -24.766 -5.303 1.00 67.23 N ATOM 1225 CA HIS A 194 -40.309 -24.793 -4.210 1.00 74.49 C ATOM 1226 C HIS A 194 -39.209 -23.723 -4.306 1.00 76.29 C ATOM 1227 O HIS A 194 -38.568 -23.369 -3.305 1.00 78.69 O ATOM 1228 CB HIS A 194 -39.654 -26.176 -4.074 1.00 77.91 C ATOM 1229 CG HIS A 194 -38.581 -26.218 -3.022 1.00 86.24 C ATOM 1230 ND1 HIS A 194 -38.858 -26.336 -1.674 1.00 90.04 N ATOM 1231 CD2 HIS A 194 -37.236 -26.089 -3.117 1.00 89.94 C ATOM 1232 CE1 HIS A 194 -37.727 -26.316 -0.990 1.00 93.46 C ATOM 1233 NE2 HIS A 194 -36.728 -26.167 -1.841 1.00 94.47 N ATOM 1234 N ARG A 195 -38.950 -23.249 -5.514 1.00 71.57 N ATOM 1235 CA ARG A 195 -37.897 -22.278 -5.716 1.00 63.96 C ATOM 1236 C ARG A 195 -38.423 -20.983 -6.284 1.00 59.24 C ATOM 1237 O ARG A 195 -37.683 -20.030 -6.383 1.00 61.24 O ATOM 1238 CB ARG A 195 -36.850 -22.873 -6.636 1.00 62.39 C ATOM 1239 CG ARG A 195 -35.863 -23.761 -5.899 1.00 62.63 C ATOM 1240 CD ARG A 195 -34.747 -24.273 -6.796 1.00 66.34 C ATOM 1241 NE ARG A 195 -33.870 -23.186 -7.241 1.00 71.32 N ATOM 1242 CZ ARG A 195 -33.656 -22.811 -8.503 1.00 67.64 C ATOM 1243 NH1 ARG A 195 -34.215 -23.426 -9.537 1.00 65.19 N ATOM 1244 NH2 ARG A 195 -32.843 -21.804 -8.720 1.00 71.04 N ATOM 1245 N HIS A 196 -39.697 -20.938 -6.652 1.00 57.67 N ATOM 1246 CA HIS A 196 -40.265 -19.729 -7.237 1.00 57.93 C ATOM 1247 C HIS A 196 -41.620 -19.420 -6.661 1.00 54.79 C ATOM 1248 O HIS A 196 -42.514 -20.283 -6.630 1.00 47.47 O ATOM 1249 CB HIS A 196 -40.462 -19.855 -8.756 1.00 63.92 C ATOM 1250 CG HIS A 196 -39.216 -20.173 -9.512 1.00 67.09 C ATOM 1251 ND1 HIS A 196 -38.888 -21.453 -9.903 1.00 71.86 N ATOM 1252 CD2 HIS A 196 -38.208 -19.380 -9.934 1.00 70.60 C ATOM 1253 CE1 HIS A 196 -37.737 -21.430 -10.549 1.00 76.83 C ATOM 1254 NE2 HIS A 196 -37.301 -20.185 -10.579 1.00 74.99 N ATOM 1255 N ARG A 197 -41.773 -18.164 -6.263 1.00 48.74 N ATOM 1256 CA ARG A 197 -43.067 -17.620 -5.949 1.00 48.87 C ATOM 1257 C ARG A 197 -43.087 -16.161 -6.281 1.00 45.58 C ATOM 1258 O ARG A 197 -42.078 -15.487 -6.228 1.00 52.89 O ATOM 1259 CB ARG A 197 -43.400 -17.779 -4.470 1.00 54.97 C ATOM 1260 CG ARG A 197 -42.217 -18.125 -3.582 1.00 61.21 C ATOM 1261 CD ARG A 197 -42.420 -17.703 -2.144 1.00 57.75 C ATOM 1262 NE ARG A 197 -43.823 -17.595 -1.743 1.00 60.68 N ATOM 1263 CZ ARG A 197 -44.338 -18.143 -0.643 1.00 60.95 C ATOM 1264 NH1 ARG A 197 -43.564 -18.877 0.163 1.00 57.47 N ATOM 1265 NH2 ARG A 197 -45.632 -17.944 -0.347 1.00 55.27 N ATOM 1266 N VAL A 198 -44.261 -15.676 -6.611 1.00 44.90 N ATOM 1267 CA VAL A 198 -44.491 -14.270 -6.769 1.00 46.49 C ATOM 1268 C VAL A 198 -45.194 -13.788 -5.514 1.00 48.04 C ATOM 1269 O VAL A 198 -46.210 -14.359 -5.109 1.00 48.63 O ATOM 1270 CB VAL A 198 -45.421 -14.010 -7.925 1.00 46.48 C ATOM 1271 CG1 VAL A 198 -45.510 -12.518 -8.162 1.00 50.36 C ATOM 1272 CG2 VAL A 198 -44.926 -14.758 -9.148 1.00 47.67 C ATOM 1273 N LEU A 199 -44.642 -12.748 -4.904 1.00 44.25 N ATOM 1274 CA LEU A 199 -45.141 -12.241 -3.638 1.00 41.17 C ATOM 1275 C LEU A 199 -46.358 -11.369 -3.861 1.00 47.28 C ATOM 1276 O LEU A 199 -46.663 -10.951 -4.998 1.00 50.31 O ATOM 1277 CB LEU A 199 -44.048 -11.431 -2.951 1.00 38.71 C ATOM 1278 CG LEU A 199 -43.157 -12.264 -2.035 1.00 42.06 C ATOM 1279 CD1 LEU A 199 -43.136 -13.742 -2.382 1.00 43.31 C ATOM 1280 CD2 LEU A 199 -41.734 -11.751 -1.952 1.00 42.46 C ATOM 1281 N ALA A 200 -47.054 -11.101 -2.764 1.00 44.33 N ATOM 1282 CA ALA A 200 -48.190 -10.207 -2.769 1.00 42.52 C ATOM 1283 C ALA A 200 -47.887 -8.889 -3.433 1.00 44.70 C ATOM 1284 O ALA A 200 -48.761 -8.355 -4.075 1.00 47.54 O ATOM 1285 CB ALA A 200 -48.650 -9.950 -1.343 1.00 43.27 C ATOM 1286 N ASN A 201 -46.690 -8.317 -3.267 1.00 46.14 N ATOM 1287 CA ASN A 201 -46.443 -7.005 -3.923 1.00 44.84 C ATOM 1288 C ASN A 201 -45.943 -7.114 -5.365 1.00 46.76 C ATOM 1289 O ASN A 201 -45.529 -6.123 -5.943 1.00 54.50 O ATOM 1290 CB ASN A 201 -45.447 -6.181 -3.130 1.00 40.43 C ATOM 1291 CG ASN A 201 -44.059 -6.688 -3.286 1.00 35.86 C ATOM 1292 OD1 ASN A 201 -43.874 -7.796 -3.704 1.00 41.28 O ATOM 1293 ND2 ASN A 201 -43.085 -5.886 -2.963 1.00 33.58 N ATOM 1294 N GLY A 202 -45.960 -8.321 -5.924 1.00 49.07 N ATOM 1295 CA GLY A 202 -45.553 -8.556 -7.307 1.00 49.06 C ATOM 1296 C GLY A 202 -44.092 -8.902 -7.514 1.00 50.13 C ATOM 1297 O GLY A 202 -43.698 -9.242 -8.616 1.00 51.20 O ATOM 1298 N ASP A 203 -43.282 -8.838 -6.462 1.00 54.47 N ATOM 1299 CA ASP A 203 -41.880 -9.208 -6.570 1.00 52.84 C ATOM 1300 C ASP A 203 -41.838 -10.663 -6.842 1.00 52.08 C ATOM 1301 O ASP A 203 -42.671 -11.400 -6.313 1.00 60.00 O ATOM 1302 CB ASP A 203 -41.151 -9.014 -5.247 1.00 54.95 C ATOM 1303 CG ASP A 203 -41.156 -7.589 -4.778 1.00 55.77 C ATOM 1304 OD1 ASP A 203 -41.747 -6.701 -5.466 1.00 59.00 O ATOM 1305 OD2 ASP A 203 -40.587 -7.386 -3.681 1.00 55.03 O ATOM 1306 N LEU A 204 -40.862 -11.106 -7.614 1.00 45.55 N ATOM 1307 CA LEU A 204 -40.710 -12.531 -7.833 1.00 47.19 C ATOM 1308 C LEU A 204 -39.567 -13.018 -6.997 1.00 49.19 C ATOM 1309 O LEU A 204 -38.432 -12.504 -7.096 1.00 48.97 O ATOM 1310 CB LEU A 204 -40.443 -12.843 -9.303 1.00 49.69 C ATOM 1311 CG LEU A 204 -39.887 -14.240 -9.579 1.00 48.85 C ATOM 1312 CD1 LEU A 204 -40.981 -15.170 -10.061 1.00 49.28 C ATOM 1313 CD2 LEU A 204 -38.767 -14.140 -10.598 1.00 51.07 C ATOM 1314 N LEU A 205 -39.846 -14.032 -6.188 1.00 45.34 N ATOM 1315 CA LEU A 205 -38.820 -14.571 -5.307 1.00 44.87 C ATOM 1316 C LEU A 205 -38.284 -15.863 -5.899 1.00 43.70 C ATOM 1317 O LEU A 205 -39.063 -16.788 -6.156 1.00 41.18 O ATOM 1318 CB LEU A 205 -39.399 -14.805 -3.918 1.00 40.66 C ATOM 1319 CG LEU A 205 -38.414 -15.267 -2.863 1.00 40.97 C ATOM 1320 CD1 LEU A 205 -37.465 -14.165 -2.404 1.00 40.91 C ATOM 1321 CD2 LEU A 205 -39.222 -15.735 -1.688 1.00 43.32 C ATOM 1322 N ILE A 206 -36.972 -15.904 -6.149 1.00 46.04 N ATOM 1323 CA ILE A 206 -36.307 -17.100 -6.696 1.00 46.41 C ATOM 1324 C ILE A 206 -35.331 -17.570 -5.666 1.00 42.80 C ATOM 1325 O ILE A 206 -34.494 -16.800 -5.240 1.00 42.17 O ATOM 1326 CB ILE A 206 -35.475 -16.776 -7.948 1.00 49.45 C ATOM 1327 CG1 ILE A 206 -36.327 -15.996 -8.934 1.00 50.11 C ATOM 1328 CG2 ILE A 206 -34.909 -18.054 -8.572 1.00 48.10 C ATOM 1329 CD1 ILE A 206 -35.684 -15.836 -10.297 1.00 53.53 C ATOM 1330 N SER A 207 -35.397 -18.831 -5.299 1.00 47.24 N ATOM 1331 CA SER A 207 -34.557 -19.353 -4.207 1.00 58.77 C ATOM 1332 C SER A 207 -33.438 -20.259 -4.696 1.00 57.87 C ATOM 1333 O SER A 207 -33.632 -21.096 -5.572 1.00 60.45 O ATOM 1334 CB SER A 207 -35.428 -20.126 -3.206 1.00 63.90 C ATOM 1335 OG SER A 207 -35.994 -19.245 -2.256 1.00 63.83 O ATOM 1336 N GLU A 208 -32.264 -20.105 -4.119 1.00 61.93 N ATOM 1337 CA GLU A 208 -31.169 -21.020 -4.413 1.00 71.95 C ATOM 1338 C GLU A 208 -30.917 -21.057 -5.910 1.00 70.02 C ATOM 1339 O GLU A 208 -31.111 -22.070 -6.578 1.00 70.65 O ATOM 1340 CB GLU A 208 -31.486 -22.427 -3.894 1.00 80.15 C ATOM 1341 CG GLU A 208 -31.631 -22.512 -2.385 1.00 88.02 C ATOM 1342 CD GLU A 208 -32.901 -23.235 -1.965 1.00 94.73 C ATOM 1343 OE1 GLU A 208 -33.168 -24.347 -2.481 1.00 93.55 O ATOM 1344 OE2 GLU A 208 -33.634 -22.690 -1.107 1.00 97.57 O ATOM 1345 N ILE A 209 -30.512 -19.917 -6.430 1.00 66.92 N ATOM 1346 CA ILE A 209 -30.306 -19.760 -7.856 1.00 62.73 C ATOM 1347 C ILE A 209 -29.180 -20.660 -8.366 1.00 66.90 C ATOM 1348 O ILE A 209 -28.138 -20.817 -7.725 1.00 69.09 O ATOM 1349 CB ILE A 209 -30.019 -18.303 -8.200 1.00 59.85 C ATOM 1350 CG1 ILE A 209 -28.877 -17.762 -7.346 1.00 58.32 C ATOM 1351 CG2 ILE A 209 -31.261 -17.460 -7.974 1.00 60.48 C ATOM 1352 CD1 ILE A 209 -28.302 -16.482 -7.901 1.00 59.31 C ATOM 1353 N LYS A 210 -29.423 -21.264 -9.517 1.00 65.89 N ATOM 1354 CA LYS A 210 -28.504 -22.196 -10.126 1.00 63.82 C ATOM 1355 C LYS A 210 -28.224 -21.668 -11.513 1.00 63.53 C ATOM 1356 O LYS A 210 -28.934 -20.792 -12.003 1.00 63.65 O ATOM 1357 CB LYS A 210 -29.130 -23.586 -10.181 1.00 68.71 C ATOM 1358 CG LYS A 210 -28.851 -24.439 -8.952 1.00 76.48 C ATOM 1359 CD LYS A 210 -28.836 -23.640 -7.642 1.00 85.00 C ATOM 1360 CE LYS A 210 -28.873 -24.493 -6.380 1.00 82.56 C ATOM 1361 NZ LYS A 210 -29.750 -25.690 -6.523 1.00 82.58 N ATOM 1362 N TRP A 211 -27.197 -22.183 -12.168 1.00 64.24 N ATOM 1363 CA TRP A 211 -26.824 -21.621 -13.454 1.00 62.85 C ATOM 1364 C TRP A 211 -27.951 -21.773 -14.457 1.00 59.00 C ATOM 1365 O TRP A 211 -28.080 -20.956 -15.349 1.00 69.82 O ATOM 1366 CB TRP A 211 -25.567 -22.266 -14.001 1.00 68.57 C ATOM 1367 CG TRP A 211 -25.225 -21.778 -15.364 1.00 77.03 C ATOM 1368 CD1 TRP A 211 -25.333 -22.473 -16.527 1.00 72.47 C ATOM 1369 CD2 TRP A 211 -24.751 -20.471 -15.715 1.00 77.56 C ATOM 1370 NE1 TRP A 211 -24.946 -21.687 -17.580 1.00 71.47 N ATOM 1371 CE2 TRP A 211 -24.571 -20.457 -17.109 1.00 77.16 C ATOM 1372 CE3 TRP A 211 -24.449 -19.320 -14.985 1.00 76.55 C ATOM 1373 CZ2 TRP A 211 -24.104 -19.338 -17.791 1.00 77.16 C ATOM 1374 CZ3 TRP A 211 -23.981 -18.204 -15.662 1.00 78.39 C ATOM 1375 CH2 TRP A 211 -23.813 -18.224 -17.053 1.00 79.93 C ATOM 1376 N GLU A 212 -28.760 -22.815 -14.309 1.00 55.65 N ATOM 1377 CA GLU A 212 -29.921 -23.012 -15.159 1.00 56.14 C ATOM 1378 C GLU A 212 -30.873 -21.827 -15.037 1.00 57.74 C ATOM 1379 O GLU A 212 -31.787 -21.668 -15.842 1.00 56.44 O ATOM 1380 CB GLU A 212 -30.650 -24.283 -14.726 1.00 59.54 C ATOM 1381 N ASP A 213 -30.644 -21.003 -14.017 1.00 59.20 N ATOM 1382 CA ASP A 213 -31.516 -19.896 -13.679 1.00 57.99 C ATOM 1383 C ASP A 213 -31.166 -18.653 -14.409 1.00 60.57 C ATOM 1384 O ASP A 213 -32.038 -17.817 -14.615 1.00 54.99 O ATOM 1385 CB ASP A 213 -31.479 -19.595 -12.181 1.00 58.33 C ATOM 1386 CG ASP A 213 -32.398 -20.499 -11.406 1.00 60.52 C ATOM 1387 OD1 ASP A 213 -33.494 -20.811 -11.917 1.00 55.04 O ATOM 1388 OD2 ASP A 213 -32.027 -20.908 -10.293 1.00 62.48 O ATOM 1389 N MET A 214 -29.899 -18.520 -14.804 1.00 62.58 N ATOM 1390 CA MET A 214 -29.458 -17.299 -15.448 1.00 58.52 C ATOM 1391 C MET A 214 -30.334 -17.052 -16.645 1.00 57.10 C ATOM 1392 O MET A 214 -30.739 -17.991 -17.330 1.00 60.81 O ATOM 1393 CB MET A 214 -27.985 -17.343 -15.832 1.00 58.85 C ATOM 1394 CG MET A 214 -27.676 -17.767 -17.232 1.00 66.05 C ATOM 1395 SD MET A 214 -27.410 -16.389 -18.360 1.00 70.17 S ATOM 1396 CE MET A 214 -28.140 -17.109 -19.817 1.00 68.82 C ATOM 1397 N GLY A 215 -30.676 -15.788 -16.856 1.00 55.75 N ATOM 1398 CA GLY A 215 -31.518 -15.430 -17.964 1.00 51.11 C ATOM 1399 C GLY A 215 -32.304 -14.190 -17.696 1.00 52.67 C ATOM 1400 O GLY A 215 -31.902 -13.338 -16.911 1.00 58.22 O ATOM 1401 N ASN A 216 -33.421 -14.089 -18.391 1.00 55.51 N ATOM 1402 CA ASN A 216 -34.285 -12.948 -18.299 1.00 59.71 C ATOM 1403 C ASN A 216 -35.626 -13.355 -17.722 1.00 59.77 C ATOM 1404 O ASN A 216 -36.173 -14.397 -18.051 1.00 59.65 O ATOM 1405 CB ASN A 216 -34.484 -12.318 -19.670 1.00 66.62 C ATOM 1406 CG ASN A 216 -33.741 -11.001 -19.819 1.00 75.53 C ATOM 1407 OD1 ASN A 216 -34.364 -9.978 -20.060 1.00 85.14 O ATOM 1408 ND2 ASN A 216 -32.414 -11.017 -19.668 1.00 74.02 N ATOM 1409 N TYR A 217 -36.152 -12.532 -16.841 1.00 53.07 N ATOM 1410 CA TYR A 217 -37.447 -12.794 -16.286 1.00 50.91 C ATOM 1411 C TYR A 217 -38.254 -11.590 -16.619 1.00 51.93 C ATOM 1412 O TYR A 217 -37.757 -10.464 -16.565 1.00 50.87 O ATOM 1413 CB TYR A 217 -37.346 -12.997 -14.785 1.00 47.22 C ATOM 1414 CG TYR A 217 -36.519 -14.198 -14.472 1.00 44.98 C ATOM 1415 CD1 TYR A 217 -35.153 -14.153 -14.526 1.00 45.15 C ATOM 1416 CD2 TYR A 217 -37.118 -15.406 -14.148 1.00 50.00 C ATOM 1417 CE1 TYR A 217 -34.402 -15.280 -14.241 1.00 46.85 C ATOM 1418 CE2 TYR A 217 -36.369 -16.534 -13.851 1.00 47.63 C ATOM 1419 CZ TYR A 217 -35.021 -16.457 -13.921 1.00 45.44 C ATOM 1420 OH TYR A 217 -34.308 -17.583 -13.663 1.00 58.85 O ATOM 1421 N LYS A 218 -39.494 -11.827 -16.989 1.00 50.58 N ATOM 1422 CA LYS A 218 -40.318 -10.770 -17.471 1.00 46.30 C ATOM 1423 C LYS A 218 -41.529 -10.611 -16.607 1.00 42.36 C ATOM 1424 O LYS A 218 -42.287 -11.540 -16.410 1.00 37.63 O ATOM 1425 CB LYS A 218 -40.794 -11.089 -18.875 1.00 46.83 C ATOM 1426 CG LYS A 218 -41.666 -9.993 -19.476 1.00 49.98 C ATOM 1427 CD LYS A 218 -42.400 -10.465 -20.717 1.00 52.84 C ATOM 1428 CE LYS A 218 -41.491 -11.103 -21.768 1.00 51.76 C ATOM 1429 NZ LYS A 218 -40.691 -10.089 -22.460 1.00 53.09 N ATOM 1430 N CYS A 219 -41.739 -9.395 -16.158 1.00 43.78 N ATOM 1431 CA CYS A 219 -42.927 -9.054 -15.434 1.00 46.33 C ATOM 1432 C CYS A 219 -43.926 -8.543 -16.442 1.00 44.28 C ATOM 1433 O CYS A 219 -43.645 -7.631 -17.175 1.00 42.57 O ATOM 1434 CB CYS A 219 -42.599 -7.966 -14.416 1.00 46.55 C ATOM 1435 SG CYS A 219 -44.042 -7.511 -13.452 1.00 53.38 S ATOM 1436 N ILE A 220 -45.096 -9.147 -16.468 1.00 47.02 N ATOM 1437 CA ILE A 220 -46.186 -8.671 -17.277 1.00 46.55 C ATOM 1438 C ILE A 220 -47.211 -8.029 -16.359 1.00 46.28 C ATOM 1439 O ILE A 220 -47.794 -8.698 -15.522 1.00 51.34 O ATOM 1440 CB ILE A 220 -46.841 -9.833 -18.044 1.00 47.32 C ATOM 1441 CG1 ILE A 220 -45.739 -10.595 -18.790 1.00 46.09 C ATOM 1442 CG2 ILE A 220 -47.974 -9.317 -18.959 1.00 47.53 C ATOM 1443 CD1 ILE A 220 -46.211 -11.806 -19.554 1.00 52.62 C ATOM 1444 N ALA A 221 -47.424 -6.735 -16.515 1.00 42.96 N ATOM 1445 CA ALA A 221 -48.404 -6.033 -15.726 1.00 42.71 C ATOM 1446 C ALA A 221 -49.568 -5.717 -16.630 1.00 47.95 C ATOM 1447 O ALA A 221 -49.382 -5.089 -17.679 1.00 52.26 O ATOM 1448 CB ALA A 221 -47.805 -4.748 -15.196 1.00 42.35 C ATOM 1449 N ARG A 222 -50.769 -6.101 -16.231 1.00 46.56 N ATOM 1450 CA ARG A 222 -51.902 -5.992 -17.107 1.00 49.21 C ATOM 1451 C ARG A 222 -53.151 -5.416 -16.403 1.00 54.02 C ATOM 1452 O ARG A 222 -53.391 -5.655 -15.213 1.00 55.49 O ATOM 1453 CB ARG A 222 -52.169 -7.403 -17.604 1.00 53.77 C ATOM 1454 CG ARG A 222 -53.471 -7.576 -18.374 1.00 66.24 C ATOM 1455 CD ARG A 222 -53.240 -7.935 -19.835 1.00 63.76 C ATOM 1456 NE ARG A 222 -53.063 -9.369 -20.004 1.00 60.11 N ATOM 1457 CZ ARG A 222 -53.968 -10.179 -20.553 1.00 58.13 C ATOM 1458 NH1 ARG A 222 -55.135 -9.699 -20.989 1.00 49.96 N ATOM 1459 NH2 ARG A 222 -53.693 -11.481 -20.673 1.00 56.93 N ATOM 1460 N ASN A 223 -53.967 -4.667 -17.130 1.00 52.63 N ATOM 1461 CA ASN A 223 -55.329 -4.400 -16.654 1.00 50.70 C ATOM 1462 C ASN A 223 -56.347 -4.394 -17.808 1.00 53.71 C ATOM 1463 O ASN A 223 -56.054 -4.815 -18.929 1.00 60.23 O ATOM 1464 CB ASN A 223 -55.383 -3.126 -15.788 1.00 48.58 C ATOM 1465 CG ASN A 223 -55.281 -1.848 -16.597 1.00 51.72 C ATOM 1466 OD1 ASN A 223 -55.435 -1.863 -17.823 1.00 56.96 O ATOM 1467 ND2 ASN A 223 -55.028 -0.724 -15.913 1.00 50.52 N ATOM 1468 N VAL A 224 -57.548 -3.926 -17.521 1.00 56.11 N ATOM 1469 CA VAL A 224 -58.636 -3.937 -18.480 1.00 56.78 C ATOM 1470 C VAL A 224 -58.198 -3.183 -19.707 1.00 58.99 C ATOM 1471 O VAL A 224 -58.562 -3.534 -20.828 1.00 57.52 O ATOM 1472 CB VAL A 224 -59.914 -3.272 -17.879 1.00 57.73 C ATOM 1473 CG1 VAL A 224 -59.796 -1.767 -17.847 1.00 56.52 C ATOM 1474 CG2 VAL A 224 -61.161 -3.659 -18.637 1.00 60.04 C ATOM 1475 N VAL A 225 -57.392 -2.154 -19.480 1.00 59.70 N ATOM 1476 CA VAL A 225 -57.123 -1.177 -20.498 1.00 55.16 C ATOM 1477 C VAL A 225 -55.747 -1.325 -21.129 1.00 52.52 C ATOM 1478 O VAL A 225 -55.434 -0.605 -22.063 1.00 54.71 O ATOM 1479 CB VAL A 225 -57.336 0.227 -19.923 1.00 60.53 C ATOM 1480 CG1 VAL A 225 -56.105 0.731 -19.197 1.00 63.17 C ATOM 1481 CG2 VAL A 225 -57.730 1.201 -21.020 1.00 66.60 C ATOM 1482 N GLY A 226 -54.920 -2.258 -20.667 1.00 47.98 N ATOM 1483 CA GLY A 226 -53.645 -2.457 -21.350 1.00 46.38 C ATOM 1484 C GLY A 226 -52.612 -3.222 -20.558 1.00 47.53 C ATOM 1485 O GLY A 226 -52.929 -3.972 -19.630 1.00 53.43 O ATOM 1486 N LYS A 227 -51.360 -3.042 -20.935 1.00 47.14 N ATOM 1487 CA LYS A 227 -50.307 -3.838 -20.362 1.00 46.41 C ATOM 1488 C LYS A 227 -49.001 -3.087 -20.394 1.00 41.59 C ATOM 1489 O LYS A 227 -48.896 -2.080 -21.045 1.00 39.05 O ATOM 1490 CB LYS A 227 -50.229 -5.191 -21.075 1.00 48.57 C ATOM 1491 CG LYS A 227 -48.894 -5.549 -21.759 1.00 53.11 C ATOM 1492 CD LYS A 227 -48.849 -5.060 -23.199 1.00 57.27 C ATOM 1493 CE LYS A 227 -47.785 -5.783 -24.022 1.00 53.62 C ATOM 1494 NZ LYS A 227 -46.655 -4.888 -24.289 1.00 50.15 N ATOM 1495 N ASP A 228 -48.041 -3.551 -19.603 1.00 42.51 N ATOM 1496 CA ASP A 228 -46.653 -3.139 -19.751 1.00 43.10 C ATOM 1497 C ASP A 228 -45.789 -4.289 -19.343 1.00 45.62 C ATOM 1498 O ASP A 228 -46.263 -5.210 -18.662 1.00 46.02 O ATOM 1499 CB ASP A 228 -46.339 -1.952 -18.863 1.00 44.50 C ATOM 1500 CG ASP A 228 -44.987 -1.342 -19.168 1.00 50.31 C ATOM 1501 OD1 ASP A 228 -44.392 -1.737 -20.198 1.00 54.05 O ATOM 1502 OD2 ASP A 228 -44.520 -0.459 -18.396 1.00 48.16 O ATOM 1503 N THR A 229 -44.524 -4.261 -19.744 1.00 46.22 N ATOM 1504 CA THR A 229 -43.616 -5.338 -19.383 1.00 43.35 C ATOM 1505 C THR A 229 -42.224 -4.879 -19.132 1.00 40.07 C ATOM 1506 O THR A 229 -41.807 -3.824 -19.569 1.00 44.57 O ATOM 1507 CB THR A 229 -43.531 -6.383 -20.502 1.00 51.13 C ATOM 1508 OG1 THR A 229 -42.719 -5.870 -21.587 1.00 46.69 O ATOM 1509 CG2 THR A 229 -44.962 -6.778 -20.968 1.00 52.30 C ATOM 1510 N ALA A 230 -41.481 -5.704 -18.428 1.00 38.39 N ATOM 1511 CA ALA A 230 -40.139 -5.330 -18.026 1.00 38.68 C ATOM 1512 C ALA A 230 -39.340 -6.599 -17.966 1.00 43.63 C ATOM 1513 O ALA A 230 -39.884 -7.701 -17.843 1.00 47.14 O ATOM 1514 CB ALA A 230 -40.143 -4.622 -16.676 1.00 33.41 C ATOM 1515 N ASP A 231 -38.038 -6.449 -18.053 1.00 42.81 N ATOM 1516 CA ASP A 231 -37.205 -7.599 -18.216 1.00 48.53 C ATOM 1517 C ASP A 231 -36.085 -7.460 -17.276 1.00 45.88 C ATOM 1518 O ASP A 231 -35.517 -6.389 -17.183 1.00 52.24 O ATOM 1519 CB ASP A 231 -36.658 -7.630 -19.638 1.00 54.80 C ATOM 1520 CG ASP A 231 -37.554 -8.346 -20.552 1.00 58.23 C ATOM 1521 OD1 ASP A 231 -38.504 -7.709 -21.070 1.00 68.90 O ATOM 1522 OD2 ASP A 231 -37.321 -9.563 -20.717 1.00 67.28 O ATOM 1523 N THR A 232 -35.756 -8.541 -16.597 1.00 43.10 N ATOM 1524 CA THR A 232 -34.682 -8.515 -15.648 1.00 42.82 C ATOM 1525 C THR A 232 -33.720 -9.629 -15.979 1.00 41.46 C ATOM 1526 O THR A 232 -34.142 -10.757 -16.174 1.00 45.85 O ATOM 1527 CB THR A 232 -35.210 -8.736 -14.211 1.00 43.79 C ATOM 1528 OG1 THR A 232 -36.041 -7.625 -13.831 1.00 46.42 O ATOM 1529 CG2 THR A 232 -34.020 -8.888 -13.208 1.00 40.12 C ATOM 1530 N PHE A 233 -32.431 -9.317 -15.987 1.00 41.07 N ATOM 1531 CA PHE A 233 -31.431 -10.296 -16.301 1.00 43.26 C ATOM 1532 C PHE A 233 -30.781 -10.810 -15.047 1.00 47.87 C ATOM 1533 O PHE A 233 -30.233 -10.025 -14.269 1.00 49.21 O ATOM 1534 CB PHE A 233 -30.360 -9.681 -17.153 1.00 41.35 C ATOM 1535 CG PHE A 233 -29.220 -10.618 -17.420 1.00 42.14 C ATOM 1536 CD1 PHE A 233 -29.412 -11.771 -18.169 1.00 41.75 C ATOM 1537 CD2 PHE A 233 -27.979 -10.363 -16.915 1.00 40.11 C ATOM 1538 CE1 PHE A 233 -28.384 -12.630 -18.427 1.00 38.79 C ATOM 1539 CE2 PHE A 233 -26.942 -11.233 -17.167 1.00 42.86 C ATOM 1540 CZ PHE A 233 -27.148 -12.364 -17.925 1.00 40.01 C ATOM 1541 N VAL A 234 -30.795 -12.125 -14.872 1.00 49.33 N ATOM 1542 CA VAL A 234 -30.246 -12.734 -13.660 1.00 49.79 C ATOM 1543 C VAL A 234 -28.978 -13.492 -14.000 1.00 49.01 C ATOM 1544 O VAL A 234 -29.018 -14.420 -14.797 1.00 40.04 O ATOM 1545 CB VAL A 234 -31.252 -13.718 -13.084 1.00 49.21 C ATOM 1546 CG1 VAL A 234 -30.644 -14.463 -11.921 1.00 49.86 C ATOM 1547 CG2 VAL A 234 -32.536 -12.998 -12.691 1.00 51.76 C ATOM 1548 N TYR A 235 -27.849 -13.102 -13.434 1.00 49.01 N ATOM 1549 CA TYR A 235 -26.637 -13.848 -13.697 1.00 50.78 C ATOM 1550 C TYR A 235 -26.118 -14.481 -12.411 1.00 47.19 C ATOM 1551 O TYR A 235 -25.561 -13.793 -11.576 1.00 48.96 O ATOM 1552 CB TYR A 235 -25.574 -12.933 -14.304 1.00 50.74 C ATOM 1553 CG TYR A 235 -24.315 -13.690 -14.721 1.00 53.01 C ATOM 1554 CD1 TYR A 235 -24.313 -14.444 -15.865 1.00 53.09 C ATOM 1555 CD2 TYR A 235 -23.141 -13.651 -13.951 1.00 52.44 C ATOM 1556 CE1 TYR A 235 -23.201 -15.140 -16.250 1.00 56.27 C ATOM 1557 CE2 TYR A 235 -22.014 -14.336 -14.338 1.00 54.16 C ATOM 1558 CZ TYR A 235 -22.057 -15.085 -15.495 1.00 55.95 C ATOM 1559 OH TYR A 235 -20.963 -15.786 -15.906 1.00 53.18 O ATOM 1560 N PRO A 236 -26.293 -15.788 -12.231 1.00 49.80 N ATOM 1561 CA PRO A 236 -25.720 -16.358 -11.009 1.00 48.62 C ATOM 1562 C PRO A 236 -24.213 -16.533 -11.101 1.00 50.52 C ATOM 1563 O PRO A 236 -23.692 -17.296 -11.932 1.00 48.20 O ATOM 1564 CB PRO A 236 -26.385 -17.714 -10.906 1.00 47.91 C ATOM 1565 CG PRO A 236 -27.442 -17.748 -11.970 1.00 50.51 C ATOM 1566 CD PRO A 236 -26.974 -16.818 -13.025 1.00 50.54 C ATOM 1567 N VAL A 237 -23.520 -15.822 -10.242 1.00 51.99 N ATOM 1568 CA VAL A 237 -22.073 -15.775 -10.294 1.00 57.78 C ATOM 1569 C VAL A 237 -21.509 -16.959 -9.490 1.00 64.04 C ATOM 1570 O VAL A 237 -22.256 -17.654 -8.811 1.00 66.65 O ATOM 1571 CB VAL A 237 -21.582 -14.393 -9.824 1.00 57.47 C ATOM 1572 CG1 VAL A 237 -22.315 -13.947 -8.586 1.00 62.20 C ATOM 1573 CG2 VAL A 237 -20.107 -14.377 -9.549 1.00 62.23 C ATOM 1574 N LEU A 238 -20.205 -17.208 -9.598 1.00 67.76 N ATOM 1575 CA LEU A 238 -19.612 -18.470 -9.169 1.00 70.31 C ATOM 1576 C LEU A 238 -18.978 -18.455 -7.777 1.00 73.79 C ATOM 1577 O LEU A 238 -18.217 -17.546 -7.440 1.00 74.38 O ATOM 1578 CB LEU A 238 -18.563 -18.870 -10.195 1.00 73.77 C ATOM 1579 CG LEU A 238 -18.081 -20.314 -10.239 1.00 76.61 C ATOM 1580 CD1 LEU A 238 -19.221 -21.278 -10.567 1.00 73.07 C ATOM 1581 CD2 LEU A 238 -16.941 -20.392 -11.254 1.00 73.01 C ATOM 1582 N ASN A 239 -19.302 -19.489 -6.995 1.00 81.89 N ATOM 1583 CA ASN A 239 -18.833 -19.678 -5.599 1.00 87.45 C ATOM 1584 C ASN A 239 -19.313 -18.588 -4.633 1.00 87.49 C ATOM 1585 O ASN A 239 -19.872 -18.880 -3.571 1.00 82.90 O ATOM 1586 CB ASN A 239 -17.295 -19.903 -5.528 1.00 86.69 C ATOM 1587 CG ASN A 239 -16.508 -18.700 -4.987 1.00 92.04 C ATOM 1588 OD1 ASN A 239 -16.926 -17.538 -5.080 1.00 92.23 O ATOM 1589 ND2 ASN A 239 -15.337 -18.989 -4.428 1.00 93.75 N TER 1590 ASN A 239 ATOM 1591 N GLY B 1 -30.999 -18.757 -20.465 1.00106.23 N ATOM 1592 CA GLY B 1 -31.621 -18.965 -21.802 1.00113.25 C ATOM 1593 C GLY B 1 -30.621 -18.778 -22.940 1.00119.65 C ATOM 1594 O GLY B 1 -29.521 -19.344 -22.880 1.00129.03 O ATOM 1595 N PRO B 2 -30.988 -18.002 -23.998 1.00119.27 N ATOM 1596 CA PRO B 2 -30.029 -17.900 -25.107 1.00109.01 C ATOM 1597 C PRO B 2 -28.693 -17.282 -24.727 1.00101.01 C ATOM 1598 O PRO B 2 -28.625 -16.318 -23.951 1.00 93.93 O ATOM 1599 CB PRO B 2 -30.750 -17.008 -26.128 1.00107.29 C ATOM 1600 CG PRO B 2 -32.188 -17.246 -25.859 1.00111.32 C ATOM 1601 CD PRO B 2 -32.270 -17.358 -24.359 1.00115.55 C ATOM 1602 N GLU B 3 -27.644 -17.868 -25.283 1.00 86.55 N ATOM 1603 CA GLU B 3 -26.308 -17.367 -25.138 1.00 77.54 C ATOM 1604 C GLU B 3 -26.250 -15.941 -25.693 1.00 70.28 C ATOM 1605 O GLU B 3 -25.590 -15.071 -25.115 1.00 60.82 O ATOM 1606 CB GLU B 3 -25.354 -18.277 -25.908 1.00 85.23 C ATOM 1607 CG GLU B 3 -24.024 -18.573 -25.227 1.00 91.81 C ATOM 1608 CD GLU B 3 -23.259 -19.695 -25.928 1.00 97.52 C ATOM 1609 OE1 GLU B 3 -23.560 -19.984 -27.111 1.00 92.94 O ATOM 1610 OE2 GLU B 3 -22.359 -20.292 -25.302 1.00 96.37 O ATOM 1611 N THR B 4 -26.939 -15.698 -26.809 1.00 63.70 N ATOM 1612 CA THR B 4 -26.873 -14.393 -27.436 1.00 58.81 C ATOM 1613 C THR B 4 -27.435 -13.358 -26.524 1.00 50.53 C ATOM 1614 O THR B 4 -26.838 -12.326 -26.323 1.00 49.04 O ATOM 1615 CB THR B 4 -27.650 -14.306 -28.755 1.00 61.32 C ATOM 1616 OG1 THR B 4 -27.566 -15.557 -29.430 1.00 72.26 O ATOM 1617 CG2 THR B 4 -27.054 -13.212 -29.641 1.00 58.58 C ATOM 1618 N LEU B 5 -28.591 -13.647 -25.964 1.00 54.61 N ATOM 1619 CA LEU B 5 -29.276 -12.690 -25.097 1.00 55.95 C ATOM 1620 C LEU B 5 -28.498 -12.443 -23.824 1.00 51.09 C ATOM 1621 O LEU B 5 -28.421 -11.325 -23.345 1.00 53.98 O ATOM 1622 CB LEU B 5 -30.684 -13.173 -24.765 1.00 55.55 C ATOM 1623 CG LEU B 5 -31.625 -12.073 -24.269 1.00 61.05 C ATOM 1624 CD1 LEU B 5 -31.416 -10.749 -25.007 1.00 64.98 C ATOM 1625 CD2 LEU B 5 -33.080 -12.509 -24.356 1.00 61.15 C ATOM 1626 N CYS B 6 -27.891 -13.485 -23.294 1.00 51.92 N ATOM 1627 CA CYS B 6 -27.048 -13.323 -22.132 1.00 53.28 C ATOM 1628 C CYS B 6 -25.905 -12.384 -22.440 1.00 50.49 C ATOM 1629 O CYS B 6 -25.583 -11.508 -21.642 1.00 48.70 O ATOM 1630 CB CYS B 6 -26.505 -14.677 -21.708 1.00 61.54 C ATOM 1631 SG CYS B 6 -25.127 -14.588 -20.543 1.00 71.78 S ATOM 1632 N GLY B 7 -25.286 -12.571 -23.606 1.00 50.19 N ATOM 1633 CA GLY B 7 -24.121 -11.747 -23.997 1.00 47.57 C ATOM 1634 C GLY B 7 -24.518 -10.308 -24.234 1.00 45.60 C ATOM 1635 O GLY B 7 -23.866 -9.372 -23.785 1.00 47.91 O ATOM 1636 N ALA B 8 -25.637 -10.122 -24.896 1.00 44.51 N ATOM 1637 CA ALA B 8 -26.098 -8.779 -25.143 1.00 47.24 C ATOM 1638 C ALA B 8 -26.324 -8.152 -23.810 1.00 47.30 C ATOM 1639 O ALA B 8 -25.796 -7.088 -23.511 1.00 52.55 O ATOM 1640 CB ALA B 8 -27.389 -8.799 -25.941 1.00 48.97 C ATOM 1641 N GLU B 9 -27.070 -8.850 -22.973 1.00 45.51 N ATOM 1642 CA GLU B 9 -27.457 -8.243 -21.712 1.00 50.09 C ATOM 1643 C GLU B 9 -26.274 -8.132 -20.749 1.00 51.10 C ATOM 1644 O GLU B 9 -26.210 -7.235 -19.906 1.00 49.47 O ATOM 1645 CB GLU B 9 -28.592 -8.996 -21.078 1.00 48.35 C ATOM 1646 CG GLU B 9 -29.326 -8.110 -20.119 1.00 57.59 C ATOM 1647 CD GLU B 9 -30.560 -7.437 -20.708 1.00 66.12 C ATOM 1648 OE1 GLU B 9 -31.449 -8.173 -21.225 1.00 65.04 O ATOM 1649 OE2 GLU B 9 -30.659 -6.177 -20.600 1.00 66.52 O ATOM 1650 N LEU B 10 -25.306 -9.015 -20.911 1.00 50.25 N ATOM 1651 CA LEU B 10 -24.120 -8.908 -20.121 1.00 55.12 C ATOM 1652 C LEU B 10 -23.345 -7.634 -20.445 1.00 55.71 C ATOM 1653 O LEU B 10 -23.021 -6.868 -19.547 1.00 53.68 O ATOM 1654 CB LEU B 10 -23.248 -10.137 -20.334 1.00 61.98 C ATOM 1655 CG LEU B 10 -22.326 -10.517 -19.166 1.00 61.76 C ATOM 1656 CD1 LEU B 10 -22.828 -10.081 -17.797 1.00 59.84 C ATOM 1657 CD2 LEU B 10 -22.120 -12.012 -19.172 1.00 62.49 C ATOM 1658 N VAL B 11 -23.051 -7.400 -21.721 1.00 53.43 N ATOM 1659 CA VAL B 11 -22.284 -6.206 -22.102 1.00 51.51 C ATOM 1660 C VAL B 11 -23.012 -4.952 -21.659 1.00 52.66 C ATOM 1661 O VAL B 11 -22.394 -3.986 -21.239 1.00 53.71 O ATOM 1662 CB VAL B 11 -22.078 -6.068 -23.631 1.00 49.37 C ATOM 1663 CG1 VAL B 11 -21.406 -4.739 -23.946 1.00 49.78 C ATOM 1664 CG2 VAL B 11 -21.250 -7.210 -24.175 1.00 47.59 C ATOM 1665 N ASP B 12 -24.328 -4.951 -21.796 1.00 53.95 N ATOM 1666 CA ASP B 12 -25.089 -3.789 -21.420 1.00 58.12 C ATOM 1667 C ASP B 12 -24.839 -3.400 -19.963 1.00 58.13 C ATOM 1668 O ASP B 12 -24.734 -2.232 -19.664 1.00 66.08 O ATOM 1669 CB ASP B 12 -26.585 -4.009 -21.669 1.00 70.77 C ATOM 1670 CG ASP B 12 -27.147 -3.099 -22.772 1.00 79.06 C ATOM 1671 OD1 ASP B 12 -26.362 -2.531 -23.589 1.00 85.27 O ATOM 1672 OD2 ASP B 12 -28.396 -2.965 -22.807 1.00 75.91 O ATOM 1673 N ALA B 13 -24.723 -4.371 -19.060 1.00 53.40 N ATOM 1674 CA ALA B 13 -24.325 -4.092 -17.677 1.00 52.85 C ATOM 1675 C ALA B 13 -22.860 -3.655 -17.549 1.00 56.94 C ATOM 1676 O ALA B 13 -22.537 -2.673 -16.869 1.00 52.71 O ATOM 1677 CB ALA B 13 -24.566 -5.319 -16.825 1.00 54.80 C ATOM 1678 N LEU B 14 -21.983 -4.400 -18.217 1.00 57.06 N ATOM 1679 CA LEU B 14 -20.556 -4.157 -18.177 1.00 53.51 C ATOM 1680 C LEU B 14 -20.153 -2.796 -18.692 1.00 54.99 C ATOM 1681 O LEU B 14 -19.124 -2.239 -18.299 1.00 61.51 O ATOM 1682 CB LEU B 14 -19.854 -5.187 -19.032 1.00 58.94 C ATOM 1683 CG LEU B 14 -19.576 -6.597 -18.482 1.00 63.28 C ATOM 1684 CD1 LEU B 14 -19.731 -6.703 -16.961 1.00 58.29 C ATOM 1685 CD2 LEU B 14 -20.411 -7.657 -19.192 1.00 65.71 C ATOM 1686 N GLN B 15 -20.942 -2.259 -19.598 1.00 56.59 N ATOM 1687 CA GLN B 15 -20.619 -0.972 -20.207 1.00 62.08 C ATOM 1688 C GLN B 15 -20.375 0.111 -19.141 1.00 64.05 C ATOM 1689 O GLN B 15 -19.487 0.946 -19.263 1.00 66.54 O ATOM 1690 CB GLN B 15 -21.749 -0.594 -21.161 1.00 64.76 C ATOM 1691 CG GLN B 15 -21.896 0.879 -21.487 1.00 69.37 C ATOM 1692 CD GLN B 15 -23.352 1.289 -21.673 1.00 70.35 C ATOM 1693 OE1 GLN B 15 -24.271 0.448 -21.630 1.00 67.38 O ATOM 1694 NE2 GLN B 15 -23.578 2.595 -21.871 1.00 71.00 N ATOM 1695 N PHE B 16 -21.113 0.025 -18.057 1.00 66.61 N ATOM 1696 CA PHE B 16 -21.014 1.029 -17.029 1.00 72.06 C ATOM 1697 C PHE B 16 -19.886 0.774 -16.068 1.00 80.39 C ATOM 1698 O PHE B 16 -19.171 1.686 -15.687 1.00 92.35 O ATOM 1699 CB PHE B 16 -22.316 1.100 -16.255 1.00 69.94 C ATOM 1700 CG PHE B 16 -23.508 1.308 -17.118 1.00 59.42 C ATOM 1701 CD1 PHE B 16 -23.646 2.456 -17.840 1.00 55.48 C ATOM 1702 CD2 PHE B 16 -24.482 0.350 -17.206 1.00 58.99 C ATOM 1703 CE1 PHE B 16 -24.737 2.650 -18.637 1.00 56.85 C ATOM 1704 CE2 PHE B 16 -25.578 0.535 -18.002 1.00 58.93 C ATOM 1705 CZ PHE B 16 -25.705 1.689 -18.718 1.00 55.58 C ATOM 1706 N VAL B 17 -19.744 -0.465 -15.647 1.00 83.19 N ATOM 1707 CA VAL B 17 -18.813 -0.762 -14.587 1.00 87.57 C ATOM 1708 C VAL B 17 -17.363 -0.467 -14.922 1.00 87.85 C ATOM 1709 O VAL B 17 -16.656 0.132 -14.134 1.00 89.95 O ATOM 1710 CB VAL B 17 -18.925 -2.236 -14.192 1.00 84.11 C ATOM 1711 CG1 VAL B 17 -17.950 -2.567 -13.083 1.00 90.99 C ATOM 1712 CG2 VAL B 17 -20.332 -2.535 -13.745 1.00 82.62 C ATOM 1713 N CYS B 18 -16.925 -0.872 -16.095 1.00 93.43 N ATOM 1714 CA CYS B 18 -15.512 -0.827 -16.384 1.00102.85 C ATOM 1715 C CYS B 18 -14.962 0.579 -16.399 1.00112.93 C ATOM 1716 O CYS B 18 -13.853 0.821 -15.929 1.00112.46 O ATOM 1717 CB CYS B 18 -15.175 -1.587 -17.659 1.00103.25 C ATOM 1718 SG CYS B 18 -14.928 -3.343 -17.335 1.00104.03 S ATOM 1719 N GLY B 19 -15.724 1.512 -16.947 1.00121.78 N ATOM 1720 CA GLY B 19 -15.181 2.837 -17.146 1.00123.97 C ATOM 1721 C GLY B 19 -14.780 3.496 -15.847 1.00128.49 C ATOM 1722 O GLY B 19 -13.689 4.035 -15.756 1.00136.27 O ATOM 1723 N ASP B 20 -15.632 3.423 -14.831 1.00128.64 N ATOM 1724 CA ASP B 20 -15.335 4.041 -13.549 1.00119.82 C ATOM 1725 C ASP B 20 -15.751 3.154 -12.391 1.00116.68 C ATOM 1726 O ASP B 20 -14.926 2.584 -11.693 1.00119.23 O ATOM 1727 CB ASP B 20 -16.094 5.363 -13.418 1.00115.49 C ATOM 1728 CG ASP B 20 -15.391 6.522 -14.091 1.00113.57 C ATOM 1729 OD1 ASP B 20 -14.655 6.294 -15.063 1.00116.29 O ATOM 1730 OD2 ASP B 20 -15.584 7.672 -13.651 1.00100.36 O ATOM 1731 N ARG B 21 -17.058 3.040 -12.206 1.00106.56 N ATOM 1732 CA ARG B 21 -17.626 2.401 -11.036 1.00 92.73 C ATOM 1733 C ARG B 21 -17.558 3.332 -9.817 1.00 90.75 C ATOM 1734 O ARG B 21 -18.505 4.050 -9.504 1.00 77.48 O ATOM 1735 CB ARG B 21 -16.957 1.045 -10.789 1.00 83.89 C ATOM 1736 CG ARG B 21 -15.983 0.967 -9.634 1.00 83.28 C ATOM 1737 CD ARG B 21 -16.112 -0.358 -8.936 1.00 80.50 C ATOM 1738 NE ARG B 21 -16.163 -1.444 -9.893 1.00 77.48 N ATOM 1739 CZ ARG B 21 -16.677 -2.632 -9.623 1.00 85.65 C ATOM 1740 NH1 ARG B 21 -17.176 -2.868 -8.429 1.00 85.55 N ATOM 1741 NH2 ARG B 21 -16.695 -3.582 -10.538 1.00 89.48 N ATOM 1742 N ILE B 43 -14.809 -13.686 -23.999 1.00 72.32 N ATOM 1743 CA ILE B 43 -14.841 -13.316 -22.582 1.00 75.96 C ATOM 1744 C ILE B 43 -16.280 -13.168 -22.152 1.00 75.99 C ATOM 1745 O ILE B 43 -16.696 -13.719 -21.147 1.00 81.52 O ATOM 1746 CB ILE B 43 -14.025 -12.031 -22.297 1.00 79.97 C ATOM 1747 CG1 ILE B 43 -14.514 -11.291 -21.040 1.00 74.77 C ATOM 1748 CG2 ILE B 43 -14.058 -11.079 -23.499 1.00 82.73 C ATOM 1749 CD1 ILE B 43 -14.834 -12.151 -19.852 1.00 72.41 C ATOM 1750 N VAL B 44 -17.063 -12.453 -22.932 1.00 75.61 N ATOM 1751 CA VAL B 44 -18.471 -12.404 -22.660 1.00 72.06 C ATOM 1752 C VAL B 44 -18.980 -13.808 -22.977 1.00 73.40 C ATOM 1753 O VAL B 44 -19.808 -14.351 -22.257 1.00 74.67 O ATOM 1754 CB VAL B 44 -19.172 -11.286 -23.476 1.00 78.56 C ATOM 1755 CG1 VAL B 44 -19.795 -11.806 -24.774 1.00 84.75 C ATOM 1756 CG2 VAL B 44 -20.222 -10.587 -22.632 1.00 79.91 C ATOM 1757 N ASP B 45 -18.447 -14.410 -24.034 1.00 71.31 N ATOM 1758 CA ASP B 45 -18.933 -15.698 -24.481 1.00 67.15 C ATOM 1759 C ASP B 45 -18.687 -16.775 -23.448 1.00 66.15 C ATOM 1760 O ASP B 45 -19.509 -17.662 -23.264 1.00 66.75 O ATOM 1761 CB ASP B 45 -18.223 -16.106 -25.746 1.00 73.95 C ATOM 1762 CG ASP B 45 -19.080 -16.960 -26.624 1.00 83.13 C ATOM 1763 OD1 ASP B 45 -19.807 -16.365 -27.444 1.00 96.50 O ATOM 1764 OD2 ASP B 45 -19.033 -18.206 -26.503 1.00 81.53 O ATOM 1765 N GLU B 46 -17.529 -16.699 -22.809 1.00 62.70 N ATOM 1766 CA GLU B 46 -17.162 -17.634 -21.771 1.00 63.59 C ATOM 1767 C GLU B 46 -18.258 -17.654 -20.708 1.00 56.55 C ATOM 1768 O GLU B 46 -18.806 -18.693 -20.343 1.00 52.38 O ATOM 1769 CB GLU B 46 -15.880 -17.127 -21.120 1.00 68.79 C ATOM 1770 CG GLU B 46 -14.860 -18.163 -20.742 1.00 74.36 C ATOM 1771 CD GLU B 46 -13.670 -17.533 -20.016 1.00 80.18 C ATOM 1772 OE1 GLU B 46 -13.496 -16.305 -20.073 1.00 85.12 O ATOM 1773 OE2 GLU B 46 -12.891 -18.258 -19.373 1.00 88.78 O ATOM 1774 N CYS B 47 -18.572 -16.459 -20.246 1.00 50.62 N ATOM 1775 CA CYS B 47 -19.317 -16.269 -19.045 1.00 50.91 C ATOM 1776 C CYS B 47 -20.798 -16.324 -19.286 1.00 56.54 C ATOM 1777 O CYS B 47 -21.589 -16.347 -18.360 1.00 60.18 O ATOM 1778 CB CYS B 47 -18.941 -14.942 -18.462 1.00 54.34 C ATOM 1779 SG CYS B 47 -17.187 -14.957 -18.012 1.00 63.04 S ATOM 1780 N CYS B 48 -21.173 -16.379 -20.546 1.00 60.32 N ATOM 1781 CA CYS B 48 -22.545 -16.589 -20.908 1.00 62.17 C ATOM 1782 C CYS B 48 -22.826 -18.040 -21.143 1.00 61.49 C ATOM 1783 O CYS B 48 -23.974 -18.449 -21.230 1.00 63.99 O ATOM 1784 CB CYS B 48 -22.876 -15.782 -22.156 1.00 65.63 C ATOM 1785 SG CYS B 48 -23.500 -14.144 -21.713 1.00 74.20 S ATOM 1786 N PHE B 49 -21.775 -18.829 -21.278 1.00 69.09 N ATOM 1787 CA PHE B 49 -21.973 -20.248 -21.502 1.00 72.97 C ATOM 1788 C PHE B 49 -21.785 -21.008 -20.202 1.00 67.79 C ATOM 1789 O PHE B 49 -22.407 -22.048 -19.992 1.00 60.75 O ATOM 1790 CB PHE B 49 -21.038 -20.799 -22.580 1.00 74.99 C ATOM 1791 CG PHE B 49 -21.289 -22.249 -22.868 1.00 82.46 C ATOM 1792 CD1 PHE B 49 -22.566 -22.691 -23.206 1.00 86.52 C ATOM 1793 CD2 PHE B 49 -20.279 -23.187 -22.736 1.00 80.31 C ATOM 1794 CE1 PHE B 49 -22.814 -24.037 -23.441 1.00 87.84 C ATOM 1795 CE2 PHE B 49 -20.519 -24.531 -22.970 1.00 80.13 C ATOM 1796 CZ PHE B 49 -21.787 -24.959 -23.324 1.00 83.17 C ATOM 1797 N ARG B 50 -20.935 -20.470 -19.336 1.00 59.62 N ATOM 1798 CA ARG B 50 -20.642 -21.077 -18.063 1.00 58.91 C ATOM 1799 C ARG B 50 -20.624 -19.947 -17.037 1.00 63.35 C ATOM 1800 O ARG B 50 -20.348 -18.811 -17.386 1.00 70.09 O ATOM 1801 CB ARG B 50 -19.276 -21.743 -18.179 1.00 62.47 C ATOM 1802 CG ARG B 50 -18.383 -21.658 -16.956 1.00 65.34 C ATOM 1803 CD ARG B 50 -17.027 -21.074 -17.283 1.00 66.54 C ATOM 1804 NE ARG B 50 -16.454 -20.389 -16.126 1.00 70.36 N ATOM 1805 CZ ARG B 50 -15.256 -19.798 -16.118 1.00 75.21 C ATOM 1806 NH1 ARG B 50 -14.482 -19.843 -17.198 1.00 70.36 N ATOM 1807 NH2 ARG B 50 -14.815 -19.170 -15.018 1.00 78.56 N ATOM 1808 N SER B 51 -20.904 -20.243 -15.772 1.00 59.25 N ATOM 1809 CA SER B 51 -20.884 -19.207 -14.740 1.00 54.23 C ATOM 1810 C SER B 51 -19.479 -18.748 -14.457 1.00 47.65 C ATOM 1811 O SER B 51 -18.622 -19.563 -14.246 1.00 57.95 O ATOM 1812 CB SER B 51 -21.479 -19.741 -13.445 1.00 59.45 C ATOM 1813 OG SER B 51 -21.250 -18.819 -12.409 1.00 63.94 O ATOM 1814 N CYS B 52 -19.239 -17.457 -14.450 1.00 44.64 N ATOM 1815 CA CYS B 52 -17.935 -16.944 -14.135 1.00 51.66 C ATOM 1816 C CYS B 52 -18.011 -16.353 -12.760 1.00 59.83 C ATOM 1817 O CYS B 52 -19.008 -16.537 -12.080 1.00 64.67 O ATOM 1818 CB CYS B 52 -17.522 -15.876 -15.125 1.00 56.77 C ATOM 1819 SG CYS B 52 -17.098 -16.562 -16.746 1.00 74.48 S ATOM 1820 N ASP B 53 -16.970 -15.646 -12.342 1.00 58.38 N ATOM 1821 CA ASP B 53 -17.000 -14.965 -11.069 1.00 61.76 C ATOM 1822 C ASP B 53 -16.442 -13.565 -11.258 1.00 62.68 C ATOM 1823 O ASP B 53 -15.865 -13.292 -12.309 1.00 65.98 O ATOM 1824 CB ASP B 53 -16.188 -15.744 -10.062 1.00 65.89 C ATOM 1825 CG ASP B 53 -14.729 -15.706 -10.363 1.00 68.21 C ATOM 1826 OD1 ASP B 53 -14.385 -15.556 -11.547 1.00 71.41 O ATOM 1827 OD2 ASP B 53 -13.923 -15.817 -9.420 1.00 76.97 O ATOM 1828 N LEU B 54 -16.589 -12.697 -10.256 1.00 56.67 N ATOM 1829 CA LEU B 54 -16.390 -11.262 -10.472 1.00 58.51 C ATOM 1830 C LEU B 54 -15.019 -10.984 -11.046 1.00 62.35 C ATOM 1831 O LEU B 54 -14.876 -10.097 -11.868 1.00 71.37 O ATOM 1832 CB LEU B 54 -16.590 -10.452 -9.190 1.00 54.75 C ATOM 1833 N ARG B 55 -14.022 -11.754 -10.620 1.00 66.48 N ATOM 1834 CA ARG B 55 -12.660 -11.601 -11.128 1.00 63.43 C ATOM 1835 C ARG B 55 -12.596 -11.714 -12.654 1.00 61.42 C ATOM 1836 O ARG B 55 -12.123 -10.803 -13.323 1.00 62.64 O ATOM 1837 CB ARG B 55 -11.737 -12.640 -10.503 1.00 63.10 C ATOM 1838 N ARG B 56 -13.079 -12.826 -13.191 1.00 62.10 N ATOM 1839 CA ARG B 56 -13.087 -13.041 -14.644 1.00 64.92 C ATOM 1840 C ARG B 56 -13.948 -12.024 -15.341 1.00 64.53 C ATOM 1841 O ARG B 56 -13.536 -11.433 -16.320 1.00 70.41 O ATOM 1842 CB ARG B 56 -13.605 -14.438 -15.000 1.00 68.93 C ATOM 1843 CG ARG B 56 -13.402 -14.862 -16.461 1.00 68.92 C ATOM 1844 CD ARG B 56 -12.004 -15.402 -16.774 1.00 63.09 C ATOM 1845 N LEU B 57 -15.153 -11.813 -14.829 1.00 71.20 N ATOM 1846 CA LEU B 57 -16.082 -10.851 -15.448 1.00 70.60 C ATOM 1847 C LEU B 57 -15.384 -9.526 -15.559 1.00 74.59 C ATOM 1848 O LEU B 57 -15.508 -8.814 -16.559 1.00 74.32 O ATOM 1849 CB LEU B 57 -17.323 -10.648 -14.591 1.00 65.44 C ATOM 1850 CG LEU B 57 -18.348 -11.767 -14.578 1.00 62.63 C ATOM 1851 CD1 LEU B 57 -19.311 -11.542 -13.438 1.00 59.14 C ATOM 1852 CD2 LEU B 57 -19.093 -11.845 -15.897 1.00 64.85 C ATOM 1853 N GLU B 58 -14.644 -9.221 -14.502 1.00 76.31 N ATOM 1854 CA GLU B 58 -13.953 -7.966 -14.394 1.00 82.38 C ATOM 1855 C GLU B 58 -12.939 -7.791 -15.516 1.00 82.98 C ATOM 1856 O GLU B 58 -12.751 -6.691 -16.010 1.00 82.89 O ATOM 1857 CB GLU B 58 -13.247 -7.876 -13.047 1.00 86.23 C ATOM 1858 CG GLU B 58 -13.497 -6.563 -12.347 1.00 91.47 C ATOM 1859 CD GLU B 58 -12.233 -6.041 -11.726 1.00105.52 C ATOM 1860 OE1 GLU B 58 -11.835 -6.586 -10.675 1.00114.46 O ATOM 1861 OE2 GLU B 58 -11.632 -5.106 -12.303 1.00102.78 O ATOM 1862 N MET B 59 -12.309 -8.875 -15.938 1.00 86.95 N ATOM 1863 CA MET B 59 -11.289 -8.783 -16.973 1.00 89.25 C ATOM 1864 C MET B 59 -12.009 -8.572 -18.281 1.00 85.61 C ATOM 1865 O MET B 59 -11.826 -9.294 -19.246 1.00 94.55 O ATOM 1866 CB MET B 59 -10.365 -10.006 -17.007 1.00 92.68 C ATOM 1867 CG MET B 59 -10.812 -11.204 -16.180 1.00 93.74 C ATOM 1868 SD MET B 59 -9.432 -12.236 -15.654 1.00 95.16 S ATOM 1869 CE MET B 59 -8.358 -12.155 -17.087 1.00 87.50 C ATOM 1870 N TYR B 60 -12.882 -7.583 -18.261 1.00 87.78 N ATOM 1871 CA TYR B 60 -13.536 -7.083 -19.437 1.00 84.08 C ATOM 1872 C TYR B 60 -12.995 -5.670 -19.695 1.00 87.45 C ATOM 1873 O TYR B 60 -13.549 -4.936 -20.504 1.00 82.11 O ATOM 1874 CB TYR B 60 -15.047 -7.053 -19.209 1.00 77.54 C ATOM 1875 CG TYR B 60 -15.798 -6.458 -20.358 1.00 71.92 C ATOM 1876 CD1 TYR B 60 -15.992 -7.172 -21.513 1.00 69.35 C ATOM 1877 CD2 TYR B 60 -16.296 -5.160 -20.293 1.00 75.84 C ATOM 1878 CE1 TYR B 60 -16.670 -6.621 -22.579 1.00 68.04 C ATOM 1879 CE2 TYR B 60 -16.966 -4.590 -21.358 1.00 70.41 C ATOM 1880 CZ TYR B 60 -17.154 -5.332 -22.495 1.00 68.88 C ATOM 1881 OH TYR B 60 -17.831 -4.789 -23.556 1.00 76.89 O ATOM 1882 N CYS B 61 -11.904 -5.310 -19.011 1.00 90.16 N ATOM 1883 CA CYS B 61 -11.276 -4.002 -19.147 1.00 89.59 C ATOM 1884 C CYS B 61 -9.856 -4.015 -18.558 1.00 84.79 C ATOM 1885 O CYS B 61 -9.020 -3.167 -18.890 1.00 73.12 O ATOM 1886 CB CYS B 61 -12.131 -2.947 -18.449 1.00 93.94 C ATOM 1887 SG CYS B 61 -12.960 -3.556 -16.949 1.00 94.76 S TER 1888 CYS B 61 HETATM 1889 O HOH A 301 -28.379 14.457 -16.351 1.00 49.69 O HETATM 1890 O HOH A 302 -54.105 -1.547 -1.592 1.00 58.13 O HETATM 1891 O HOH A 303 -31.465 15.240 -13.437 1.00 41.90 O HETATM 1892 O HOH A 304 -48.815 22.435 -24.280 1.00 78.59 O HETATM 1893 O HOH A 305 -27.955 9.541 -18.253 1.00 57.70 O HETATM 1894 O HOH A 306 -39.716 -24.141 -8.066 1.00 58.94 O HETATM 1895 O HOH A 307 -41.016 -20.225 0.000 0.50 48.88 O HETATM 1896 O HOH A 308 -15.005 0.171 0.369 1.00 72.97 O HETATM 1897 O HOH A 309 -41.014 -24.715 0.000 0.50 77.67 O HETATM 1898 O HOH A 310 -43.021 -27.330 -3.516 1.00 62.28 O HETATM 1899 O HOH A 311 -17.711 4.109 4.994 1.00 57.79 O HETATM 1900 O HOH A 312 -28.194 23.219 -19.814 1.00 51.98 O HETATM 1901 O HOH B 101 -18.386 -5.853 -11.908 1.00 54.15 O HETATM 1902 O HOH B 102 -12.821 0.187 -20.607 1.00 53.94 O CONECT 195 615 CONECT 615 195 CONECT 1035 1435 CONECT 1435 1035 CONECT 1631 1785 CONECT 1718 1887 CONECT 1779 1819 CONECT 1785 1631 CONECT 1819 1779 CONECT 1887 1718 MASTER 417 0 0 5 19 0 0 6 1900 2 10 25 END
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Related entries of code: 6ff3
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Protein Sequence Similarity
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70aa, >1IMX_1|Chain... at 100%
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PDBbind
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Complexes with the same small molecule ligand
PDB Code
Check Database
Ligand Name
No complexes with the same small molecule ligand are found!
Entry Information
PDB ID
6ff3
Complex Type
Protein-Protein
PDBbind Subset
general set
Protein Name
Drosophila melanogaster Neural/ectodermal development factor IMP-L2
Ligand Name
Human Insulin-like growth factor I, IGF-I
EC.Number
E.C.-.-.-.-
Resolution
2.57(Å)
Affinity (Kd/Ki/IC50)
Kd=13.6nM
Release Year
2018
Protein/NA Sequence
Check fasta file
Primary Reference
(2018) Nat Commun Vol. 9: pp. 3860-3860
Links to External Databases
RCSB PDB
The mother database
PDBsum
Enhanced annotations on PDB entries
Pubchem
Comprehensive collection of chemical and biological data
UniProtKB AC
UniProt accession number (AC):
Q09024
P05019
Entrez Gene ID
NCBI Entrez Gene ID:
38513
3479
ASD
Information of known allosteric effects of PDB entries
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