Browse entries in the PDBbind-CN Database

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Related entries of code: 6mq3
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
3e4aRCSB PDB    PDBbind1019aa, >3E4A_1|Chains... *
4dttRCSB PDB    PDBbind990aa, >4DTT_1|Chains... at 98%
4dwkRCSB PDB    PDBbind990aa, >4DWK_1|Chains... at 98%
4gs8RCSB PDB    PDBbind990aa, >4GS8_1|Chains... at 98%
4gscRCSB PDB    PDBbind990aa, >4GSC_1|Chains... at 98%
4ifhRCSB PDB    PDBbind990aa, >4IFH_1|Chains... at 98%
4lteRCSB PDB    PDBbind978aa, >4LTE_1|Chains... at 100%
4nxoRCSB PDB    PDBbind990aa, >4NXO_1|Chains... at 98%
4re9RCSB PDB    PDBbind990aa, >4RE9_1|Chains... at 98%
6byzRCSB PDB    PDBbind1019aa, >6BYZ_1|Chains... at 100%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
6edsRCSB PDB    PDBbindJ22
Entry Information
PDB ID6mq3
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameInsulin-degrading enzyme
Ligand NameJ22
EC.Number E.C.3.4.24.56
Resolution 3.57(Å)
Affinity (Kd/Ki/IC50)Ki=1.7nM
Release Year2019
Protein/NA SequenceCheck fasta file
Primary Reference (2019) Nat.Chem.Biol. Vol. 15: pp. 565-574
Ligand Properties
Formula C27H35N4O3S
Molecular Weight 495.657
Exact Mass 495.243
No. of atoms 70
No. of bonds 74
Polar Surface Area 88.25
LOGP Value 3.35      (Computed with XLOGP3)
4.49      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 2
No. of Hydrogen Bond Acceptors: 4
No. of Rotatable Bonds: 6
No. of Nitrogen and Oxygen Atoms: 7
No. of Rings: 5
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): P14735  
Entrez Gene IDNCBI Entrez Gene ID: 3416  
ASDInformation of known allosteric effects of PDB entries
 
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