Browse entries in the PDBbind-CN Database

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Related entries of code: 6p10
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
6p14RCSB PDB    PDBbind314aa, >6P14_1|Chain... at 99%
6p12RCSB PDB    PDBbind313aa, >6P12_1|Chain... at 100%
6p11RCSB PDB    PDBbind314aa, >6P11_1|Chain... at 99%
6nywRCSB PDB    PDBbind314aa, >6NYW_1|Chain... at 99%
6nyvRCSB PDB    PDBbind314aa, >6NYV_1|Chain... *
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
3amaRCSB PDB    PDBbindSKE
4qmuRCSB PDB    PDBbindSKE
5usyRCSB PDB    PDBbindSKE
5uszRCSB PDB    PDBbindSKE
6p11RCSB PDB    PDBbindSKE
5winRCSB PDB    PDBbindSKE
Entry Information
PDB ID6p10
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameDrosophila melanogaster Spastin AAA domain (N527C mutant)
Ligand NameSKE
EC.Number E.C.5.6.1.1
Resolution 2.3(Å)
Affinity (Kd/Ki/IC50)IC50=6.0uM
Release Year2019
Protein/NA SequenceCheck fasta file
Primary Reference (2019) Cell Chem Biol Vol. 26: pp. 1263-1273
Ligand Properties
Formula C15H12F2N6O3S
Molecular Weight 394.356
Exact Mass 394.066
No. of atoms 39
No. of bonds 41
Polar Surface Area 154.37
LOGP Value 2.39      (Computed with XLOGP3)
3.65      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 3
No. of Hydrogen Bond Acceptors: 5
No. of Rotatable Bonds: 5
No. of Nitrogen and Oxygen Atoms: 9
No. of Rings: 3
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): Q8I0P1  
Entrez Gene IDNCBI Entrez Gene ID: 42846  
ASDInformation of known allosteric effects of PDB entries
 
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