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HEADER    GENE REGULATION/RNA                     27-FEB-04   1SI3              
TITLE     CRYSTAL STRUCTURE OF THE PAZ DOMAIN OF HUMAN EIF2C1 IN                
TITLE    2 COMPLEX WITH A 9-MER SIRNA-LIKE DUPLEX                               
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3';                       
COMPND   3 CHAIN: B;                                                            
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2C 1;             
COMPND   7 CHAIN: A;                                                            
COMPND   8 FRAGMENT: PAZ DOMAIN (RESIDUES 225-369);                             
COMPND   9 SYNONYM: EIF2C 1, EIF-2C 1, PUTATIVE RNA-BINDING PROTEIN             
COMPND  10 Q99, ARGONAUTE1;                                                     
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 SYNTHETIC: YES;                                                      
SOURCE   3 MOL_ID: 2;                                                           
SOURCE   4 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   5 ORGANISM_COMMON: HUMAN;                                              
SOURCE   6 ORGANISM_TAXID: 9606;                                                
SOURCE   7 GENE: EIF2C1;                                                        
SOURCE   8 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE   9 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  10 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE  11 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  12 EXPRESSION_SYSTEM_PLASMID: PET19B                                    
KEYWDS    PROTEIN-RNA COMPLEX, RNA INTERFERENCE, DOUBLE HELIX,                  
KEYWDS   2 OVERHANG, GENE REGULATION/RNA COMPLEX                                
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    K.YE,J.B.MA,D.PATEL                                                   
REVDAT   2   24-FEB-09 1SI3    1       VERSN                                    
REVDAT   1   25-MAY-04 1SI3    0                                                
JRNL        AUTH   J.B.MA,K.YE,D.J.PATEL                                        
JRNL        TITL   STRUCTURAL BASIS FOR OVERHANG-SPECIFIC SMALL                 
JRNL        TITL 2 INTERFERING RNA RECOGNITION BY THE PAZ DOMAIN.               
JRNL        REF    NATURE                        V. 429   318 2004              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   15152257                                                     
JRNL        DOI    10.1038/NATURE02519                                          
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.1                                              
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,             
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : ENGH & HUBER                                    
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.83                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL                           
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL                           
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 93.6                           
REMARK   3   NUMBER OF REFLECTIONS             : 5908                           
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.247                           
REMARK   3   FREE R VALUE                     : 0.304                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 10.000                          
REMARK   3   FREE R VALUE TEST SET COUNT      : 593                             
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.012                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 10                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.60                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.69                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 89.80                        
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 503                          
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3960                       
REMARK   3   BIN FREE R VALUE                    : 0.5010                       
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 10.30                        
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 58                           
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.066                        
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 977                                     
REMARK   3   NUCLEIC ACID ATOMS       : 185                                     
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 15                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 59.20                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 58.90                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 3.73000                                              
REMARK   3    B22 (A**2) : 3.73000                                              
REMARK   3    B33 (A**2) : -7.47000                                             
REMARK   3    B12 (A**2) : 4.90000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.41                            
REMARK   3   ESD FROM SIGMAA              (A) : 0.48                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.59                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.58                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.008                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.20                            
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 21.00                           
REMARK   3   IMPROPER ANGLES        (DEGREES) : 1.17                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED                                
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.600 ; 1.500                
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 2.770 ; 2.000                
REMARK   3   SIDE-CHAIN BOND              (A**2) : 1.900 ; 2.000                
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 3.000 ; 2.500                
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : FLAT MODEL                                           
REMARK   3   KSOL        : 0.32                                                 
REMARK   3   BSOL        : 35.01                                                
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM                              
REMARK   3  PARAMETER FILE  2  : DNA-RNA_REP.PARAM                              
REMARK   3  PARAMETER FILE  3  : WATER_REP.PARAM                                
REMARK   3  PARAMETER FILE  4  : ION.PARAM                                      
REMARK   3  PARAMETER FILE  5  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP                                    
REMARK   3  TOPOLOGY FILE  2   : DNA-RNA.TOP                                    
REMARK   3  TOPOLOGY FILE  3   : WATER.TOP                                      
REMARK   3  TOPOLOGY FILE  4   : ION.TOP                                        
REMARK   3  TOPOLOGY FILE  5   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1SI3 COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-MAR-04.                  
REMARK 100 THE RCSB ID CODE IS RCSB021726.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 18-OCT-03                          
REMARK 200  TEMPERATURE           (KELVIN) : 100.0                              
REMARK 200  PH                             : 7.60                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 19-BM                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9796                             
REMARK 200  MONOCHROMATOR                  : SI 111                             
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH                        
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 6431                               
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.600                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9                               
REMARK 200  DATA REDUNDANCY                : 12.600                             
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.11500                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 28.6000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.69                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0                              
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : 0.66300                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 3.400                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SAD                                            
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD                          
REMARK 200 SOFTWARE USED: CNS 1.1                                               
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 50.00                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.49                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: PEG 1000, POTASSIUM CHLORIDE, HEPES      
REMARK 280  -NAOH, DITHIOTHREITOL, PH 7.60, VAPOR DIFFUSION, HANGING DROP,      
REMARK 280  TEMPERATURE 293K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 64                             
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+1/3                                            
REMARK 290       3555   -X+Y,-X,Z+2/3                                           
REMARK 290       4555   -X,-Y,Z                                                 
REMARK 290       5555   Y,-X+Y,Z+1/3                                            
REMARK 290       6555   X-Y,X,Z+2/3                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       11.64433            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       23.28867            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   5  0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   5 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       11.64433            
REMARK 290   SMTRY1   6  0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       23.28867            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300 REMARK: THE BIOLOGICAL ASSEMBLE CONSISTS OF TWO PAZ DOMAINS          
REMARK 300 BOUND TO EACH END OF A 9-MER SIRNA-LIKE DUPLEX GENERATED FROM        
REMARK 300 THE PROTEIN MONOMER AND THE 9-MER SINGLE STRANDED RNA IN THE         
REMARK 300 ASYMMETRIC UNIT BY THE OPERATION: -X+1,-Y+2,Z.                       
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, A                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000      172.85694            
REMARK 350   BIOMT3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLY A   221                                                      
REMARK 465     SER A   222                                                      
REMARK 465     HIS A   223                                                      
REMARK 465     LEU A   296                                                      
REMARK 465     GLU A   297                                                      
REMARK 465     SER A   298                                                      
REMARK 465     GLY A   299                                                      
REMARK 465     GLN A   300                                                      
REMARK 465     THR A   301                                                      
REMARK 465     CYS A   350                                                      
REMARK 465     ILE A   351                                                      
REMARK 465     LYS A   352                                                      
REMARK 465     LYS A   353                                                      
REMARK 465     LEU A   354                                                      
REMARK 465     THR A   355                                                      
REMARK 465     ASP A   356                                                      
REMARK 465     ASN A   357                                                      
REMARK 465     GLN A   358                                                      
REMARK 465     THR A   359                                                      
REMARK 465     SER A   360                                                      
REMARK 465     THR A   361                                                      
REMARK 465     MSE A   362                                                      
REMARK 465     ILE A   363                                                      
REMARK 465     LYS A   364                                                      
REMARK 465     ALA A   365                                                      
REMARK 465     THR A   366                                                      
REMARK 465     ALA A   367                                                      
REMARK 465     ARG A   368                                                      
REMARK 465     SER A   369                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;            
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     MSE A 224    CG  SE    CE                                        
REMARK 470     GLN A 295    CG   CD   OE1  NE2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A 240       38.44    -92.47                                   
REMARK 500    PRO A 245       29.75    -79.10                                   
REMARK 500    ASN A 281      171.60    176.21                                   
REMARK 500    LYS A 333      -16.11   -160.35                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500      U B 407         0.07    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1SI2   RELATED DB: PDB                                   
DBREF  1SI3 A  225   369  UNP    Q9UL18   I2C1_HUMAN     225    369             
DBREF  1SI3 B  401   409  PDB    1SI3     1SI3           401    409             
SEQADV 1SI3 GLY A  221  UNP  Q9UL18              CLONING ARTIFACT               
SEQADV 1SI3 SER A  222  UNP  Q9UL18              CLONING ARTIFACT               
SEQADV 1SI3 HIS A  223  UNP  Q9UL18              CLONING ARTIFACT               
SEQADV 1SI3 MSE A  224  UNP  Q9UL18              CLONING ARTIFACT               
SEQADV 1SI3 MSE A  232  UNP  Q9UL18    MET   232 MODIFIED RESIDUE               
SEQADV 1SI3 MSE A  273  UNP  Q9UL18    MET   273 MODIFIED RESIDUE               
SEQADV 1SI3 MSE A  362  UNP  Q9UL18    MET   362 MODIFIED RESIDUE               
SEQRES   1 B    9    C   G   U   G   A   C   U   C   U                          
SEQRES   1 A  149  GLY SER HIS MSE ALA GLN PRO VAL ILE GLU PHE MSE CYS          
SEQRES   2 A  149  GLU VAL LEU ASP ILE ARG ASN ILE ASP GLU GLN PRO LYS          
SEQRES   3 A  149  PRO LEU THR ASP SER GLN ARG VAL ARG PHE THR LYS GLU          
SEQRES   4 A  149  ILE LYS GLY LEU LYS VAL GLU VAL THR HIS CYS GLY GLN          
SEQRES   5 A  149  MSE LYS ARG LYS TYR ARG VAL CYS ASN VAL THR ARG ARG          
SEQRES   6 A  149  PRO ALA SER HIS GLN THR PHE PRO LEU GLN LEU GLU SER          
SEQRES   7 A  149  GLY GLN THR VAL GLU CYS THR VAL ALA GLN TYR PHE LYS          
SEQRES   8 A  149  GLN LYS TYR ASN LEU GLN LEU LYS TYR PRO HIS LEU PRO          
SEQRES   9 A  149  CYS LEU GLN VAL GLY GLN GLU GLN LYS HIS THR TYR LEU          
SEQRES  10 A  149  PRO LEU GLU VAL CYS ASN ILE VAL ALA GLY GLN ARG CYS          
SEQRES  11 A  149  ILE LYS LYS LEU THR ASP ASN GLN THR SER THR MSE ILE          
SEQRES  12 A  149  LYS ALA THR ALA ARG SER                                      
MODRES 1SI3 MSE A  224  MET  SELENOMETHIONINE                                   
MODRES 1SI3 MSE A  232  MET  SELENOMETHIONINE                                   
MODRES 1SI3 MSE A  273  MET  SELENOMETHIONINE                                   
HET    MSE  A 224       5                                                       
HET    MSE  A 232       8                                                       
HET    MSE  A 273       8                                                       
HETNAM     MSE SELENOMETHIONINE                                                 
FORMUL   2  MSE    3(C5 H11 N O2 SE)                                            
FORMUL   3  HOH   *15(H2 O)                                                     
HELIX    1   1 VAL A  228  ASP A  237  1                                  10    
HELIX    2   2 THR A  249  LYS A  261  1                                  13    
HELIX    3   3 VAL A  306  LYS A  313  1                                   8    
SHEET    1   A 6 GLN A 226  PRO A 227  0                                        
SHEET    2   A 6 CYS A 342  ILE A 344 -1  O  ILE A 344   N  GLN A 226           
SHEET    3   A 6 LYS A 264  VAL A 267 -1  N  GLU A 266   O  ASN A 343           
SHEET    4   A 6 LYS A 276  PRO A 286 -1  O  TYR A 277   N  VAL A 265           
SHEET    5   A 6 PRO A 324  VAL A 328 -1  O  CYS A 325   N  THR A 283           
SHEET    6   A 6 THR A 335  PRO A 338 -1  O  LEU A 337   N  LEU A 326           
SHEET    1   B 2 THR A 291  PRO A 293  0                                        
SHEET    2   B 2 GLU A 303  THR A 305 -1  O  CYS A 304   N  PHE A 292           
LINK         C   MSE A 224                 N   ALA A 225     1555   1555  1.33  
LINK         C   PHE A 231                 N   MSE A 232     1555   1555  1.33  
LINK         C   MSE A 232                 N   CYS A 233     1555   1555  1.33  
LINK         C   GLN A 272                 N   MSE A 273     1555   1555  1.32  
LINK         C   MSE A 273                 N   LYS A 274     1555   1555  1.33  
CRYST1   99.799   99.799   34.933  90.00  90.00 120.00 P 64          6          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.010020  0.005785  0.000000        0.00000                         
SCALE2      0.000000  0.011570  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.028626        0.00000                         
ATOM      1  O5'   C B 401      -5.697  85.680   3.624  1.00 63.33           O  
ATOM      2  C5'   C B 401      -6.393  84.924   4.607  1.00 60.47           C  
ATOM      3  C4'   C B 401      -7.474  84.091   3.959  1.00 59.60           C  
ATOM      4  O4'   C B 401      -8.475  84.963   3.367  1.00 59.55           O  
ATOM      5  C3'   C B 401      -7.054  83.220   2.787  1.00 58.67           C  
ATOM      6  O3'   C B 401      -6.384  82.034   3.198  1.00 57.85           O  
ATOM      7  C2'   C B 401      -8.396  82.940   2.120  1.00 59.15           C  
ATOM      8  O2'   C B 401      -9.160  81.924   2.742  1.00 58.65           O  
ATOM      9  C1'   C B 401      -9.093  84.294   2.277  1.00 59.73           C  
ATOM     10  N1    C B 401      -8.933  85.111   1.068  1.00 59.81           N  
ATOM     11  C2    C B 401      -9.708  84.796  -0.053  1.00 59.25           C  
ATOM     12  O2    C B 401     -10.532  83.885   0.032  1.00 60.09           O  
ATOM     13  N3    C B 401      -9.541  85.495  -1.193  1.00 60.40           N  
ATOM     14  C4    C B 401      -8.652  86.491  -1.241  1.00 61.36           C  
ATOM     15  N4    C B 401      -8.518  87.152  -2.396  1.00 61.16           N  
ATOM     16  C5    C B 401      -7.859  86.852  -0.104  1.00 60.63           C  
ATOM     17  C6    C B 401      -8.034  86.142   1.021  1.00 59.90           C  
ATOM     18  P     G B 402      -5.236  81.392   2.258  1.00 58.18           P  
ATOM     19  OP1   G B 402      -4.731  80.198   2.987  1.00 59.06           O  
ATOM     20  OP2   G B 402      -4.273  82.450   1.833  1.00 56.71           O  
ATOM     21  O5'   G B 402      -6.031  80.884   0.971  1.00 55.55           O  
ATOM     22  C5'   G B 402      -6.908  79.766   1.053  1.00 54.41           C  
ATOM     23  C4'   G B 402      -7.522  79.479  -0.297  1.00 54.07           C  
ATOM     24  O4'   G B 402      -8.422  80.559  -0.656  1.00 54.21           O  
ATOM     25  C3'   G B 402      -6.551  79.401  -1.463  1.00 53.33           C  
ATOM     26  O3'   G B 402      -5.962  78.120  -1.594  1.00 53.33           O  
ATOM     27  C2'   G B 402      -7.446  79.717  -2.649  1.00 53.26           C  
ATOM     28  O2'   G B 402      -8.205  78.611  -3.099  1.00 52.95           O  
ATOM     29  C1'   G B 402      -8.344  80.800  -2.052  1.00 53.85           C  
ATOM     30  N9    G B 402      -7.756  82.116  -2.242  1.00 54.58           N  
ATOM     31  C8    G B 402      -7.199  82.920  -1.279  1.00 55.06           C  
ATOM     32  N7    G B 402      -6.730  84.038  -1.755  1.00 55.67           N  
ATOM     33  C5    G B 402      -6.999  83.970  -3.115  1.00 55.65           C  
ATOM     34  C6    G B 402      -6.725  84.896  -4.153  1.00 55.97           C  
ATOM     35  O6    G B 402      -6.174  85.995  -4.076  1.00 55.99           O  
ATOM     36  N1    G B 402      -7.171  84.427  -5.384  1.00 56.03           N  
ATOM     37  C2    G B 402      -7.802  83.224  -5.589  1.00 54.30           C  
ATOM     38  N2    G B 402      -8.160  82.953  -6.844  1.00 53.31           N  
ATOM     39  N3    G B 402      -8.062  82.354  -4.632  1.00 54.55           N  
ATOM     40  C4    G B 402      -7.635  82.790  -3.428  1.00 54.76           C  
ATOM     41  P     U B 403      -4.478  77.996  -2.182  1.00 54.17           P  
ATOM     42  OP1   U B 403      -4.033  76.597  -1.986  1.00 55.30           O  
ATOM     43  OP2   U B 403      -3.665  79.102  -1.630  1.00 54.82           O  
ATOM     44  O5'   U B 403      -4.644  78.292  -3.739  1.00 54.11           O  
ATOM     45  C5'   U B 403      -5.493  77.502  -4.559  1.00 53.84           C  
ATOM     46  C4'   U B 403      -5.596  78.119  -5.937  1.00 55.59           C  
ATOM     47  O4'   U B 403      -6.225  79.427  -5.822  1.00 55.61           O  
ATOM     48  C3'   U B 403      -4.280  78.388  -6.663  1.00 55.77           C  
ATOM     49  O3'   U B 403      -3.828  77.227  -7.362  1.00 56.95           O  
ATOM     50  C2'   U B 403      -4.679  79.504  -7.625  1.00 55.16           C  
ATOM     51  O2'   U B 403      -5.367  79.042  -8.764  1.00 54.56           O  
ATOM     52  C1'   U B 403      -5.659  80.311  -6.772  1.00 55.43           C  
ATOM     53  N1    U B 403      -5.027  81.420  -6.047  1.00 56.06           N  
ATOM     54  C2    U B 403      -4.801  82.587  -6.743  1.00 56.25           C  
ATOM     55  O2    U B 403      -5.088  82.715  -7.909  1.00 56.24           O  
ATOM     56  N3    U B 403      -4.224  83.598  -6.016  1.00 57.73           N  
ATOM     57  C4    U B 403      -3.854  83.557  -4.686  1.00 58.26           C  
ATOM     58  O4    U B 403      -3.428  84.580  -4.145  1.00 58.17           O  
ATOM     59  C5    U B 403      -4.108  82.303  -4.035  1.00 57.15           C  
ATOM     60  C6    U B 403      -4.674  81.303  -4.722  1.00 55.91           C  
ATOM     61  P     G B 404      -2.260  76.864  -7.393  1.00 58.57           P  
ATOM     62  OP1   G B 404      -2.086  75.427  -7.723  1.00 58.07           O  
ATOM     63  OP2   G B 404      -1.671  77.404  -6.148  1.00 57.53           O  
ATOM     64  O5'   G B 404      -1.674  77.719  -8.595  1.00 60.09           O  
ATOM     65  C5'   G B 404      -2.101  77.485  -9.928  1.00 60.47           C  
ATOM     66  C4'   G B 404      -1.831  78.700 -10.770  1.00 60.55           C  
ATOM     67  O4'   G B 404      -2.664  79.790 -10.294  1.00 60.74           O  
ATOM     68  C3'   G B 404      -0.414  79.252 -10.682  1.00 59.71           C  
ATOM     69  O3'   G B 404       0.492  78.554 -11.537  1.00 57.96           O  
ATOM     70  C2'   G B 404      -0.623  80.699 -11.102  1.00 60.47           C  
ATOM     71  O2'   G B 404      -0.731  80.853 -12.501  1.00 59.11           O  
ATOM     72  C1'   G B 404      -1.957  81.011 -10.414  1.00 62.06           C  
ATOM     73  N9    G B 404      -1.723  81.548  -9.077  1.00 65.94           N  
ATOM     74  C8    G B 404      -1.617  80.877  -7.879  1.00 67.93           C  
ATOM     75  N7    G B 404      -1.330  81.665  -6.874  1.00 68.26           N  
ATOM     76  C5    G B 404      -1.263  82.926  -7.447  1.00 70.93           C  
ATOM     77  C6    G B 404      -0.974  84.198  -6.870  1.00 72.43           C  
ATOM     78  O6    G B 404      -0.720  84.480  -5.691  1.00 72.51           O  
ATOM     79  N1    G B 404      -0.996  85.201  -7.830  1.00 74.06           N  
ATOM     80  C2    G B 404      -1.263  85.007  -9.168  1.00 73.95           C  
ATOM     81  N2    G B 404      -1.220  86.088  -9.951  1.00 73.06           N  
ATOM     82  N3    G B 404      -1.541  83.846  -9.707  1.00 71.15           N  
ATOM     83  C4    G B 404      -1.520  82.860  -8.803  1.00 69.01           C  
ATOM     84  P     A B 405       2.052  78.619 -11.224  1.00 55.36           P  
ATOM     85  OP1   A B 405       2.722  77.736 -12.200  1.00 58.21           O  
ATOM     86  OP2   A B 405       2.236  78.388  -9.777  1.00 56.16           O  
ATOM     87  O5'   A B 405       2.421  80.128 -11.560  1.00 56.30           O  
ATOM     88  C5'   A B 405       2.156  80.660 -12.853  1.00 56.11           C  
ATOM     89  C4'   A B 405       2.791  82.019 -13.004  1.00 56.20           C  
ATOM     90  O4'   A B 405       1.977  83.029 -12.358  1.00 54.76           O  
ATOM     91  C3'   A B 405       4.163  82.201 -12.373  1.00 56.22           C  
ATOM     92  O3'   A B 405       5.220  81.679 -13.167  1.00 55.57           O  
ATOM     93  C2'   A B 405       4.251  83.715 -12.287  1.00 56.29           C  
ATOM     94  O2'   A B 405       4.593  84.292 -13.533  1.00 56.24           O  
ATOM     95  C1'   A B 405       2.815  84.074 -11.890  1.00 56.13           C  
ATOM     96  N9    A B 405       2.670  84.169 -10.436  1.00 57.96           N  
ATOM     97  C8    A B 405       2.048  83.292  -9.580  1.00 57.66           C  
ATOM     98  N7    A B 405       2.117  83.645  -8.320  1.00 57.75           N  
ATOM     99  C5    A B 405       2.828  84.838  -8.344  1.00 58.02           C  
ATOM    100  C6    A B 405       3.240  85.724  -7.324  1.00 57.54           C  
ATOM    101  N6    A B 405       3.004  85.527  -6.025  1.00 55.09           N  
ATOM    102  N1    A B 405       3.917  86.832  -7.692  1.00 58.06           N  
ATOM    103  C2    A B 405       4.169  87.027  -8.994  1.00 58.87           C  
ATOM    104  N3    A B 405       3.841  86.270 -10.040  1.00 58.26           N  
ATOM    105  C4    A B 405       3.167  85.177  -9.642  1.00 57.94           C  
ATOM    106  P     C B 406       6.674  81.475 -12.512  1.00 57.38           P  
ATOM    107  OP1   C B 406       7.501  80.710 -13.490  1.00 57.02           O  
ATOM    108  OP2   C B 406       6.510  80.955 -11.130  1.00 55.41           O  
ATOM    109  O5'   C B 406       7.263  82.952 -12.387  1.00 57.30           O  
ATOM    110  C5'   C B 406       7.521  83.745 -13.539  1.00 58.42           C  
ATOM    111  C4'   C B 406       8.270  84.995 -13.149  1.00 59.06           C  
ATOM    112  O4'   C B 406       7.423  85.826 -12.313  1.00 59.62           O  
ATOM    113  C3'   C B 406       9.495  84.745 -12.298  1.00 59.85           C  
ATOM    114  O3'   C B 406      10.617  84.425 -13.095  1.00 60.54           O  
ATOM    115  C2'   C B 406       9.653  86.065 -11.557  1.00 59.58           C  
ATOM    116  O2'   C B 406      10.262  87.072 -12.339  1.00 59.63           O  
ATOM    117  C1'   C B 406       8.194  86.424 -11.282  1.00 59.43           C  
ATOM    118  N1    C B 406       7.692  85.923  -9.986  1.00 59.83           N  
ATOM    119  C2    C B 406       7.503  86.828  -8.928  1.00 59.43           C  
ATOM    120  O2    C B 406       7.767  88.025  -9.107  1.00 60.07           O  
ATOM    121  N3    C B 406       7.033  86.373  -7.741  1.00 58.13           N  
ATOM    122  C4    C B 406       6.750  85.080  -7.587  1.00 57.08           C  
ATOM    123  N4    C B 406       6.273  84.681  -6.408  1.00 53.47           N  
ATOM    124  C5    C B 406       6.938  84.138  -8.639  1.00 59.37           C  
ATOM    125  C6    C B 406       7.408  84.599  -9.811  1.00 59.72           C  
ATOM    126  P     U B 407      11.730  83.443 -12.506  1.00 63.20           P  
ATOM    127  OP1   U B 407      12.651  83.052 -13.606  1.00 62.72           O  
ATOM    128  OP2   U B 407      11.024  82.396 -11.722  1.00 63.52           O  
ATOM    129  O5'   U B 407      12.534  84.358 -11.486  1.00 65.08           O  
ATOM    130  C5'   U B 407      13.306  85.456 -11.953  1.00 66.03           C  
ATOM    131  C4'   U B 407      13.815  86.268 -10.793  1.00 66.16           C  
ATOM    132  O4'   U B 407      12.714  86.961 -10.158  1.00 67.00           O  
ATOM    133  C3'   U B 407      14.444  85.488  -9.654  1.00 66.83           C  
ATOM    134  O3'   U B 407      15.776  85.113  -9.994  1.00 66.83           O  
ATOM    135  C2'   U B 407      14.373  86.503  -8.511  1.00 67.64           C  
ATOM    136  O2'   U B 407      15.430  87.442  -8.479  1.00 68.28           O  
ATOM    137  C1'   U B 407      13.056  87.234  -8.810  1.00 68.35           C  
ATOM    138  N1    U B 407      11.954  86.808  -7.932  1.00 71.08           N  
ATOM    139  C2    U B 407      11.397  87.757  -7.083  1.00 72.09           C  
ATOM    140  O2    U B 407      11.720  88.934  -7.095  1.00 73.59           O  
ATOM    141  N3    U B 407      10.451  87.273  -6.215  1.00 71.84           N  
ATOM    142  C4    U B 407      10.005  85.977  -6.114  1.00 71.15           C  
ATOM    143  O4    U B 407       9.268  85.671  -5.179  1.00 72.04           O  
ATOM    144  C5    U B 407      10.583  85.069  -7.058  1.00 71.33           C  
ATOM    145  C6    U B 407      11.511  85.504  -7.914  1.00 71.63           C  
ATOM    146  P     C B 408      16.494  83.890  -9.234  1.00 68.35           P  
ATOM    147  OP1   C B 408      16.488  84.179  -7.776  1.00 66.55           O  
ATOM    148  OP2   C B 408      17.788  83.643  -9.919  1.00 67.57           O  
ATOM    149  O5'   C B 408      15.582  82.615  -9.560  1.00 69.14           O  
ATOM    150  C5'   C B 408      14.596  82.153  -8.638  1.00 67.82           C  
ATOM    151  C4'   C B 408      13.931  80.886  -9.145  1.00 67.03           C  
ATOM    152  O4'   C B 408      13.459  81.079 -10.505  1.00 68.00           O  
ATOM    153  C3'   C B 408      14.773  79.626  -9.262  1.00 65.57           C  
ATOM    154  O3'   C B 408      14.901  78.968  -8.009  1.00 61.33           O  
ATOM    155  C2'   C B 408      13.933  78.764 -10.201  1.00 66.59           C  
ATOM    156  O2'   C B 408      12.895  78.089  -9.532  1.00 66.99           O  
ATOM    157  C1'   C B 408      13.307  79.811 -11.124  1.00 68.74           C  
ATOM    158  N1    C B 408      13.901  79.838 -12.472  1.00 71.96           N  
ATOM    159  C2    C B 408      13.446  78.906 -13.429  1.00 74.06           C  
ATOM    160  O2    C B 408      12.564  78.095 -13.111  1.00 76.67           O  
ATOM    161  N3    C B 408      13.976  78.917 -14.667  1.00 74.37           N  
ATOM    162  C4    C B 408      14.921  79.807 -14.976  1.00 75.21           C  
ATOM    163  N4    C B 408      15.414  79.785 -16.218  1.00 75.46           N  
ATOM    164  C5    C B 408      15.404  80.762 -14.026  1.00 74.20           C  
ATOM    165  C6    C B 408      14.872  80.740 -12.798  1.00 72.47           C  
ATOM    166  P     U B 409      16.228  78.135  -7.695  1.00 59.43           P  
ATOM    167  OP1   U B 409      16.202  77.642  -6.300  1.00 57.47           O  
ATOM    168  OP2   U B 409      17.354  78.993  -8.154  1.00 60.95           O  
ATOM    169  O5'   U B 409      16.143  76.876  -8.665  1.00 58.57           O  
ATOM    170  C5'   U B 409      15.363  75.739  -8.321  1.00 57.58           C  
ATOM    171  C4'   U B 409      15.257  74.799  -9.497  1.00 56.89           C  
ATOM    172  O4'   U B 409      14.746  75.530 -10.638  1.00 57.97           O  
ATOM    173  C3'   U B 409      16.558  74.210 -10.007  1.00 56.29           C  
ATOM    174  O3'   U B 409      17.016  73.106  -9.236  1.00 56.09           O  
ATOM    175  C2'   U B 409      16.202  73.826 -11.434  1.00 56.89           C  
ATOM    176  O2'   U B 409      15.516  72.601 -11.524  1.00 56.51           O  
ATOM    177  C1'   U B 409      15.274  74.974 -11.833  1.00 58.92           C  
ATOM    178  N1    U B 409      15.996  76.028 -12.557  1.00 61.92           N  
ATOM    179  C2    U B 409      15.704  76.197 -13.891  1.00 63.56           C  
ATOM    180  O2    U B 409      14.868  75.522 -14.478  1.00 62.92           O  
ATOM    181  N3    U B 409      16.428  77.184 -14.516  1.00 65.35           N  
ATOM    182  C4    U B 409      17.392  77.997 -13.948  1.00 63.97           C  
ATOM    183  O4    U B 409      17.947  78.852 -14.639  1.00 63.44           O  
ATOM    184  C5    U B 409      17.631  77.761 -12.562  1.00 63.00           C  
ATOM    185  C6    U B 409      16.942  76.813 -11.928  1.00 62.47           C  
TER     186        U B 409                                                      
HETATM  187  N   MSE A 224       3.327  77.739  12.245  1.00 60.73           N  
HETATM  188  CA  MSE A 224       4.715  77.619  11.707  1.00 60.87           C  
HETATM  189  C   MSE A 224       4.821  76.664  10.500  1.00 60.79           C  
HETATM  190  O   MSE A 224       3.949  75.813  10.257  1.00 60.33           O  
HETATM  191  CB  MSE A 224       5.664  77.153  12.820  1.00 59.75           C  
ATOM    192  N   ALA A 225       5.899  76.822   9.740  1.00 58.52           N  
ATOM    193  CA  ALA A 225       6.138  75.984   8.577  1.00 55.89           C  
ATOM    194  C   ALA A 225       6.933  74.731   8.989  1.00 53.69           C  
ATOM    195  O   ALA A 225       7.934  74.829   9.712  1.00 53.90           O  
ATOM    196  CB  ALA A 225       6.902  76.781   7.532  1.00 55.86           C  
ATOM    197  N   GLN A 226       6.484  73.561   8.534  1.00 49.86           N  
ATOM    198  CA  GLN A 226       7.152  72.293   8.857  1.00 45.99           C  
ATOM    199  C   GLN A 226       8.080  71.851   7.743  1.00 42.40           C  
ATOM    200  O   GLN A 226       7.652  71.740   6.607  1.00 43.73           O  
ATOM    201  CB  GLN A 226       6.115  71.202   9.090  1.00 44.25           C  
ATOM    202  CG  GLN A 226       6.696  69.802   9.118  1.00 46.82           C  
ATOM    203  CD  GLN A 226       5.623  68.722   9.168  1.00 48.64           C  
ATOM    204  OE1 GLN A 226       4.705  68.688   8.331  1.00 48.26           O  
ATOM    205  NE2 GLN A 226       5.734  67.828  10.148  1.00 48.27           N  
ATOM    206  N   PRO A 227       9.363  71.590   8.052  1.00 41.16           N  
ATOM    207  CA  PRO A 227      10.349  71.151   7.036  1.00 38.82           C  
ATOM    208  C   PRO A 227       9.779  69.956   6.292  1.00 36.81           C  
ATOM    209  O   PRO A 227       9.207  69.073   6.925  1.00 35.69           O  
ATOM    210  CB  PRO A 227      11.561  70.765   7.873  1.00 37.26           C  
ATOM    211  CG  PRO A 227      11.453  71.686   9.058  1.00 39.49           C  
ATOM    212  CD  PRO A 227       9.969  71.626   9.393  1.00 39.20           C  
ATOM    213  N   VAL A 228       9.912  69.900   4.971  1.00 36.18           N  
ATOM    214  CA  VAL A 228       9.306  68.765   4.304  1.00 38.31           C  
ATOM    215  C   VAL A 228      10.021  67.497   4.690  1.00 40.88           C  
ATOM    216  O   VAL A 228       9.402  66.422   4.671  1.00 42.17           O  
ATOM    217  CB  VAL A 228       9.215  68.889   2.742  1.00 38.11           C  
ATOM    218  CG1 VAL A 228       9.154  70.348   2.318  1.00 37.67           C  
ATOM    219  CG2 VAL A 228      10.320  68.130   2.083  1.00 36.78           C  
ATOM    220  N   ILE A 229      11.301  67.605   5.065  1.00 41.45           N  
ATOM    221  CA  ILE A 229      12.033  66.416   5.491  1.00 42.58           C  
ATOM    222  C   ILE A 229      11.271  65.777   6.642  1.00 44.32           C  
ATOM    223  O   ILE A 229      11.022  64.570   6.634  1.00 45.60           O  
ATOM    224  CB  ILE A 229      13.445  66.730   5.988  1.00 42.73           C  
ATOM    225  CG1 ILE A 229      14.442  66.678   4.834  1.00 43.97           C  
ATOM    226  CG2 ILE A 229      13.869  65.686   7.008  1.00 42.10           C  
ATOM    227  CD1 ILE A 229      14.832  65.267   4.445  1.00 43.04           C  
ATOM    228  N   GLU A 230      10.909  66.593   7.630  1.00 45.11           N  
ATOM    229  CA  GLU A 230      10.160  66.129   8.801  1.00 46.43           C  
ATOM    230  C   GLU A 230       8.806  65.552   8.434  1.00 45.98           C  
ATOM    231  O   GLU A 230       8.372  64.541   8.997  1.00 46.58           O  
ATOM    232  CB  GLU A 230       9.952  67.273   9.787  1.00 47.90           C  
ATOM    233  CG  GLU A 230      11.135  67.519  10.680  1.00 52.72           C  
ATOM    234  CD  GLU A 230      10.868  68.592  11.710  1.00 56.22           C  
ATOM    235  OE1 GLU A 230       9.771  68.580  12.336  1.00 54.48           O  
ATOM    236  OE2 GLU A 230      11.772  69.438  11.894  1.00 57.53           O  
ATOM    237  N   PHE A 231       8.130  66.208   7.500  1.00 45.47           N  
ATOM    238  CA  PHE A 231       6.834  65.740   7.053  1.00 45.17           C  
ATOM    239  C   PHE A 231       7.035  64.320   6.496  1.00 45.87           C  
ATOM    240  O   PHE A 231       6.283  63.394   6.821  1.00 44.35           O  
ATOM    241  CB  PHE A 231       6.293  66.685   5.981  1.00 43.97           C  
ATOM    242  CG  PHE A 231       4.938  66.307   5.473  1.00 41.84           C  
ATOM    243  CD1 PHE A 231       3.837  66.332   6.313  1.00 42.46           C  
ATOM    244  CD2 PHE A 231       4.761  65.931   4.154  1.00 39.82           C  
ATOM    245  CE1 PHE A 231       2.566  65.987   5.843  1.00 40.85           C  
ATOM    246  CE2 PHE A 231       3.502  65.587   3.679  1.00 40.66           C  
ATOM    247  CZ  PHE A 231       2.405  65.617   4.524  1.00 40.59           C  
HETATM  248  N   MSE A 232       8.073  64.158   5.679  1.00 46.35           N  
HETATM  249  CA  MSE A 232       8.395  62.868   5.088  1.00 48.45           C  
HETATM  250  C   MSE A 232       8.636  61.787   6.131  1.00 48.44           C  
HETATM  251  O   MSE A 232       8.047  60.704   6.068  1.00 49.68           O  
HETATM  252  CB  MSE A 232       9.634  62.981   4.225  1.00 51.77           C  
HETATM  253  CG  MSE A 232      10.095  61.652   3.653  1.00 57.63           C  
HETATM  254 SE   MSE A 232      11.912  61.783   2.903  1.00 69.42          SE  
HETATM  255  CE  MSE A 232      11.463  62.232   1.084  1.00 66.87           C  
ATOM    256  N   CYS A 233       9.512  62.066   7.087  1.00 47.34           N  
ATOM    257  CA  CYS A 233       9.809  61.085   8.121  1.00 46.75           C  
ATOM    258  C   CYS A 233       8.531  60.643   8.836  1.00 46.93           C  
ATOM    259  O   CYS A 233       8.399  59.487   9.231  1.00 47.39           O  
ATOM    260  CB  CYS A 233      10.838  61.649   9.112  1.00 46.39           C  
ATOM    261  SG  CYS A 233      12.546  61.871   8.418  1.00 46.92           S  
ATOM    262  N   GLU A 234       7.578  61.553   8.987  1.00 47.27           N  
ATOM    263  CA  GLU A 234       6.319  61.206   9.641  1.00 47.24           C  
ATOM    264  C   GLU A 234       5.497  60.297   8.747  1.00 46.75           C  
ATOM    265  O   GLU A 234       4.858  59.352   9.211  1.00 45.64           O  
ATOM    266  CB  GLU A 234       5.510  62.464   9.950  1.00 48.60           C  
ATOM    267  CG  GLU A 234       6.013  63.251  11.138  1.00 52.01           C  
ATOM    268  CD  GLU A 234       5.258  64.556  11.333  1.00 54.36           C  
ATOM    269  OE1 GLU A 234       5.540  65.258  12.328  1.00 53.99           O  
ATOM    270  OE2 GLU A 234       4.386  64.876  10.490  1.00 53.58           O  
ATOM    271  N   VAL A 235       5.506  60.595   7.455  1.00 46.95           N  
ATOM    272  CA  VAL A 235       4.763  59.796   6.496  1.00 46.60           C  
ATOM    273  C   VAL A 235       5.357  58.383   6.385  1.00 49.10           C  
ATOM    274  O   VAL A 235       4.639  57.376   6.447  1.00 47.47           O  
ATOM    275  CB  VAL A 235       4.776  60.485   5.123  1.00 45.58           C  
ATOM    276  CG1 VAL A 235       4.114  59.598   4.071  1.00 44.79           C  
ATOM    277  CG2 VAL A 235       4.071  61.838   5.224  1.00 42.30           C  
ATOM    278  N   LEU A 236       6.678  58.311   6.259  1.00 51.89           N  
ATOM    279  CA  LEU A 236       7.360  57.030   6.117  1.00 54.90           C  
ATOM    280  C   LEU A 236       7.677  56.341   7.441  1.00 58.05           C  
ATOM    281  O   LEU A 236       8.254  55.247   7.450  1.00 56.40           O  
ATOM    282  CB  LEU A 236       8.652  57.227   5.325  1.00 53.35           C  
ATOM    283  CG  LEU A 236       8.504  57.961   3.989  1.00 52.75           C  
ATOM    284  CD1 LEU A 236       9.824  57.929   3.252  1.00 51.86           C  
ATOM    285  CD2 LEU A 236       7.424  57.310   3.144  1.00 51.11           C  
ATOM    286  N   ASP A 237       7.289  56.974   8.548  1.00 61.76           N  
ATOM    287  CA  ASP A 237       7.558  56.439   9.881  1.00 66.19           C  
ATOM    288  C   ASP A 237       9.060  56.246  10.093  1.00 69.31           C  
ATOM    289  O   ASP A 237       9.508  55.175  10.496  1.00 69.88           O  
ATOM    290  CB  ASP A 237       6.841  55.106  10.087  1.00 67.16           C  
ATOM    291  CG  ASP A 237       5.364  55.276  10.386  1.00 69.81           C  
ATOM    292  OD1 ASP A 237       4.623  54.271  10.286  1.00 69.25           O  
ATOM    293  OD2 ASP A 237       4.946  56.408  10.732  1.00 71.28           O  
ATOM    294  N   ILE A 238       9.833  57.286   9.801  1.00 71.85           N  
ATOM    295  CA  ILE A 238      11.279  57.249   9.976  1.00 74.40           C  
ATOM    296  C   ILE A 238      11.613  58.122  11.174  1.00 78.20           C  
ATOM    297  O   ILE A 238      11.003  59.172  11.369  1.00 79.46           O  
ATOM    298  CB  ILE A 238      12.016  57.815   8.746  1.00 71.88           C  
ATOM    299  CG1 ILE A 238      11.950  56.825   7.592  1.00 70.72           C  
ATOM    300  CG2 ILE A 238      13.450  58.097   9.088  1.00 70.31           C  
ATOM    301  CD1 ILE A 238      12.672  57.295   6.365  1.00 69.18           C  
ATOM    302  N   ARG A 239      12.576  57.692  11.978  1.00 82.13           N  
ATOM    303  CA  ARG A 239      12.972  58.464  13.147  1.00 85.78           C  
ATOM    304  C   ARG A 239      14.431  58.866  13.029  1.00 87.07           C  
ATOM    305  O   ARG A 239      14.813  59.992  13.345  1.00 87.28           O  
ATOM    306  CB  ARG A 239      12.769  57.636  14.413  1.00 87.94           C  
ATOM    307  CG  ARG A 239      11.334  57.166  14.612  1.00 91.14           C  
ATOM    308  CD  ARG A 239      11.143  56.517  15.977  1.00 93.32           C  
ATOM    309  NE  ARG A 239       9.727  56.388  16.314  1.00 95.46           N  
ATOM    310  CZ  ARG A 239       9.264  56.216  17.549  1.00 95.89           C  
ATOM    311  NH1 ARG A 239      10.106  56.147  18.572  1.00 95.83           N  
ATOM    312  NH2 ARG A 239       7.956  56.134  17.765  1.00 95.12           N  
ATOM    313  N   ASN A 240      15.226  57.921  12.545  1.00 89.31           N  
ATOM    314  CA  ASN A 240      16.665  58.072  12.367  1.00 91.05           C  
ATOM    315  C   ASN A 240      17.045  58.564  10.975  1.00 90.46           C  
ATOM    316  O   ASN A 240      18.050  58.127  10.417  1.00 90.26           O  
ATOM    317  CB  ASN A 240      17.321  56.715  12.593  1.00 94.13           C  
ATOM    318  CG  ASN A 240      16.689  55.620  11.735  1.00 95.84           C  
ATOM    319  OD1 ASN A 240      15.598  55.124  12.037  1.00 96.71           O  
ATOM    320  ND2 ASN A 240      17.365  55.254  10.649  1.00 95.85           N  
ATOM    321  N   ILE A 241      16.263  59.475  10.416  1.00 90.07           N  
ATOM    322  CA  ILE A 241      16.545  59.958   9.075  1.00 90.48           C  
ATOM    323  C   ILE A 241      18.029  60.077   8.749  1.00 91.02           C  
ATOM    324  O   ILE A 241      18.463  59.656   7.677  1.00 90.88           O  
ATOM    325  CB  ILE A 241      15.868  61.313   8.806  1.00 90.19           C  
ATOM    326  CG1 ILE A 241      16.193  61.761   7.381  1.00 88.87           C  
ATOM    327  CG2 ILE A 241      16.308  62.338   9.844  1.00 90.01           C  
ATOM    328  CD1 ILE A 241      15.428  62.958   6.937  1.00 89.02           C  
ATOM    329  N   ASP A 242      18.806  60.633   9.673  1.00 91.95           N  
ATOM    330  CA  ASP A 242      20.243  60.813   9.451  1.00 92.54           C  
ATOM    331  C   ASP A 242      21.124  59.630   9.830  1.00 92.13           C  
ATOM    332  O   ASP A 242      22.342  59.679   9.659  1.00 91.40           O  
ATOM    333  CB  ASP A 242      20.734  62.061  10.183  1.00 92.26           C  
ATOM    334  CG  ASP A 242      20.766  63.274   9.288  1.00 93.16           C  
ATOM    335  OD1 ASP A 242      21.035  64.384   9.787  1.00 93.90           O  
ATOM    336  OD2 ASP A 242      20.527  63.117   8.075  1.00 93.99           O  
ATOM    337  N   GLU A 243      20.506  58.571  10.337  1.00 91.94           N  
ATOM    338  CA  GLU A 243      21.232  57.375  10.739  1.00 92.00           C  
ATOM    339  C   GLU A 243      21.480  56.528   9.491  1.00 91.70           C  
ATOM    340  O   GLU A 243      22.566  55.980   9.290  1.00 90.73           O  
ATOM    341  CB  GLU A 243      20.393  56.603  11.755  1.00 92.47           C  
ATOM    342  CG  GLU A 243      21.171  55.693  12.681  1.00 94.76           C  
ATOM    343  CD  GLU A 243      20.284  55.064  13.741  1.00 95.80           C  
ATOM    344  OE1 GLU A 243      19.342  54.332  13.367  1.00 96.41           O  
ATOM    345  OE2 GLU A 243      20.523  55.304  14.946  1.00 96.15           O  
ATOM    346  N   GLN A 244      20.456  56.445   8.648  1.00 91.64           N  
ATOM    347  CA  GLN A 244      20.533  55.685   7.411  1.00 91.62           C  
ATOM    348  C   GLN A 244      20.611  56.630   6.216  1.00 90.48           C  
ATOM    349  O   GLN A 244      19.599  57.195   5.791  1.00 91.54           O  
ATOM    350  CB  GLN A 244      19.296  54.805   7.240  1.00 93.26           C  
ATOM    351  CG  GLN A 244      18.979  53.875   8.397  1.00 95.51           C  
ATOM    352  CD  GLN A 244      17.748  53.024   8.113  1.00 96.77           C  
ATOM    353  OE1 GLN A 244      17.744  52.211   7.185  1.00 96.71           O  
ATOM    354  NE2 GLN A 244      16.695  53.214   8.904  1.00 97.69           N  
ATOM    355  N   PRO A 245      21.815  56.832   5.668  1.00 88.30           N  
ATOM    356  CA  PRO A 245      21.949  57.725   4.510  1.00 85.75           C  
ATOM    357  C   PRO A 245      21.517  56.999   3.226  1.00 83.42           C  
ATOM    358  O   PRO A 245      22.011  57.292   2.133  1.00 84.46           O  
ATOM    359  CB  PRO A 245      23.441  58.064   4.506  1.00 85.91           C  
ATOM    360  CG  PRO A 245      23.848  57.873   5.948  1.00 86.99           C  
ATOM    361  CD  PRO A 245      23.119  56.613   6.315  1.00 87.46           C  
ATOM    362  N   LYS A 246      20.587  56.058   3.375  1.00 78.96           N  
ATOM    363  CA  LYS A 246      20.080  55.249   2.264  1.00 74.31           C  
ATOM    364  C   LYS A 246      18.941  55.908   1.482  1.00 69.90           C  
ATOM    365  O   LYS A 246      18.077  56.568   2.058  1.00 68.74           O  
ATOM    366  CB  LYS A 246      19.610  53.908   2.817  1.00 76.23           C  
ATOM    367  CG  LYS A 246      20.527  53.369   3.906  1.00 78.47           C  
ATOM    368  CD  LYS A 246      19.887  52.231   4.673  1.00 80.36           C  
ATOM    369  CE  LYS A 246      20.724  51.856   5.892  1.00 82.06           C  
ATOM    370  NZ  LYS A 246      20.104  50.745   6.674  1.00 81.83           N  
ATOM    371  N   PRO A 247      18.922  55.724   0.152  1.00 66.28           N  
ATOM    372  CA  PRO A 247      17.878  56.310  -0.693  1.00 62.78           C  
ATOM    373  C   PRO A 247      16.504  55.708  -0.411  1.00 59.87           C  
ATOM    374  O   PRO A 247      16.388  54.625   0.165  1.00 59.19           O  
ATOM    375  CB  PRO A 247      18.356  55.997  -2.113  1.00 62.55           C  
ATOM    376  CG  PRO A 247      19.829  55.833  -1.961  1.00 64.50           C  
ATOM    377  CD  PRO A 247      19.930  55.049  -0.679  1.00 65.23           C  
ATOM    378  N   LEU A 248      15.463  56.418  -0.822  1.00 56.71           N  
ATOM    379  CA  LEU A 248      14.108  55.944  -0.615  1.00 53.46           C  
ATOM    380  C   LEU A 248      13.808  54.806  -1.573  1.00 52.63           C  
ATOM    381  O   LEU A 248      14.342  54.758  -2.682  1.00 50.55           O  
ATOM    382  CB  LEU A 248      13.108  57.071  -0.855  1.00 51.13           C  
ATOM    383  CG  LEU A 248      13.081  58.240   0.119  1.00 50.31           C  
ATOM    384  CD1 LEU A 248      12.142  59.298  -0.425  1.00 48.90           C  
ATOM    385  CD2 LEU A 248      12.645  57.774   1.495  1.00 46.60           C  
ATOM    386  N   THR A 249      12.959  53.885  -1.131  1.00 51.19           N  
ATOM    387  CA  THR A 249      12.560  52.770  -1.969  1.00 51.87           C  
ATOM    388  C   THR A 249      11.409  53.275  -2.829  1.00 51.51           C  
ATOM    389  O   THR A 249      10.852  54.340  -2.560  1.00 53.14           O  
ATOM    390  CB  THR A 249      12.063  51.585  -1.129  1.00 52.97           C  
ATOM    391  OG1 THR A 249      11.013  52.031  -0.255  1.00 53.45           O  
ATOM    392  CG2 THR A 249      13.211  50.990  -0.313  1.00 51.63           C  
ATOM    393  N   ASP A 250      11.056  52.515  -3.858  1.00 50.10           N  
ATOM    394  CA  ASP A 250       9.969  52.890  -4.753  1.00 48.14           C  
ATOM    395  C   ASP A 250       8.673  52.969  -3.946  1.00 46.91           C  
ATOM    396  O   ASP A 250       7.794  53.810  -4.191  1.00 45.00           O  
ATOM    397  CB  ASP A 250       9.856  51.851  -5.859  1.00 48.51           C  
ATOM    398  CG  ASP A 250      11.157  51.685  -6.627  1.00 51.78           C  
ATOM    399  OD1 ASP A 250      11.408  52.522  -7.522  1.00 51.08           O  
ATOM    400  OD2 ASP A 250      11.930  50.732  -6.327  1.00 48.64           O  
ATOM    401  N   SER A 251       8.577  52.091  -2.961  1.00 44.11           N  
ATOM    402  CA  SER A 251       7.421  52.059  -2.101  1.00 41.83           C  
ATOM    403  C   SER A 251       7.400  53.337  -1.257  1.00 43.21           C  
ATOM    404  O   SER A 251       6.357  53.965  -1.089  1.00 42.47           O  
ATOM    405  CB  SER A 251       7.495  50.821  -1.214  1.00 38.95           C  
ATOM    406  OG  SER A 251       6.406  50.744  -0.324  1.00 40.15           O  
ATOM    407  N   GLN A 252       8.556  53.734  -0.733  1.00 44.91           N  
ATOM    408  CA  GLN A 252       8.606  54.932   0.091  1.00 46.14           C  
ATOM    409  C   GLN A 252       8.337  56.184  -0.737  1.00 46.13           C  
ATOM    410  O   GLN A 252       7.604  57.079  -0.301  1.00 46.56           O  
ATOM    411  CB  GLN A 252       9.960  55.058   0.777  1.00 47.57           C  
ATOM    412  CG  GLN A 252      10.243  53.981   1.807  1.00 50.54           C  
ATOM    413  CD  GLN A 252      11.697  54.006   2.284  1.00 51.53           C  
ATOM    414  OE1 GLN A 252      12.642  53.837   1.492  1.00 49.26           O  
ATOM    415  NE2 GLN A 252      11.880  54.223   3.583  1.00 51.25           N  
ATOM    416  N   ARG A 253       8.923  56.248  -1.928  1.00 43.54           N  
ATOM    417  CA  ARG A 253       8.721  57.397  -2.788  1.00 42.74           C  
ATOM    418  C   ARG A 253       7.253  57.554  -3.142  1.00 43.89           C  
ATOM    419  O   ARG A 253       6.731  58.666  -3.127  1.00 43.85           O  
ATOM    420  CB  ARG A 253       9.548  57.263  -4.067  1.00 42.02           C  
ATOM    421  CG  ARG A 253       9.327  58.377  -5.089  1.00 40.64           C  
ATOM    422  CD  ARG A 253      10.372  58.320  -6.202  1.00 41.26           C  
ATOM    423  NE  ARG A 253      10.523  56.974  -6.734  1.00 42.25           N  
ATOM    424  CZ  ARG A 253       9.566  56.309  -7.370  1.00 44.60           C  
ATOM    425  NH1 ARG A 253       9.799  55.080  -7.808  1.00 45.16           N  
ATOM    426  NH2 ARG A 253       8.379  56.869  -7.579  1.00 44.23           N  
ATOM    427  N   VAL A 254       6.587  56.443  -3.459  1.00 45.39           N  
ATOM    428  CA  VAL A 254       5.172  56.480  -3.828  1.00 44.61           C  
ATOM    429  C   VAL A 254       4.260  56.949  -2.702  1.00 45.89           C  
ATOM    430  O   VAL A 254       3.322  57.721  -2.946  1.00 46.59           O  
ATOM    431  CB  VAL A 254       4.679  55.113  -4.323  1.00 44.47           C  
ATOM    432  CG1 VAL A 254       3.145  55.081  -4.345  1.00 43.93           C  
ATOM    433  CG2 VAL A 254       5.225  54.853  -5.719  1.00 43.23           C  
ATOM    434  N   ARG A 255       4.527  56.487  -1.478  1.00 44.37           N  
ATOM    435  CA  ARG A 255       3.723  56.890  -0.327  1.00 42.87           C  
ATOM    436  C   ARG A 255       3.960  58.359   0.003  1.00 41.16           C  
ATOM    437  O   ARG A 255       3.033  59.085   0.371  1.00 42.60           O  
ATOM    438  CB  ARG A 255       4.056  56.047   0.897  1.00 44.88           C  
ATOM    439  CG  ARG A 255       3.365  54.697   0.938  1.00 51.48           C  
ATOM    440  CD  ARG A 255       3.665  53.997   2.252  1.00 55.79           C  
ATOM    441  NE  ARG A 255       5.000  53.409   2.252  1.00 60.66           N  
ATOM    442  CZ  ARG A 255       5.793  53.367   3.314  1.00 62.82           C  
ATOM    443  NH1 ARG A 255       5.386  53.888   4.465  1.00 65.00           N  
ATOM    444  NH2 ARG A 255       6.988  52.795   3.226  1.00 65.75           N  
ATOM    445  N   PHE A 256       5.202  58.796  -0.125  1.00 34.71           N  
ATOM    446  CA  PHE A 256       5.516  60.172   0.154  1.00 32.67           C  
ATOM    447  C   PHE A 256       4.888  61.100  -0.894  1.00 34.37           C  
ATOM    448  O   PHE A 256       4.332  62.146  -0.545  1.00 34.07           O  
ATOM    449  CB  PHE A 256       7.033  60.353   0.177  1.00 30.99           C  
ATOM    450  CG  PHE A 256       7.482  61.779   0.383  1.00 27.97           C  
ATOM    451  CD1 PHE A 256       8.390  62.365  -0.491  1.00 28.85           C  
ATOM    452  CD2 PHE A 256       7.068  62.506   1.490  1.00 26.18           C  
ATOM    453  CE1 PHE A 256       8.882  63.641  -0.254  1.00 27.60           C  
ATOM    454  CE2 PHE A 256       7.564  63.782   1.724  1.00 23.24           C  
ATOM    455  CZ  PHE A 256       8.463  64.342   0.858  1.00 24.00           C  
ATOM    456  N   THR A 257       4.969  60.724  -2.173  1.00 33.83           N  
ATOM    457  CA  THR A 257       4.425  61.562  -3.228  1.00 33.38           C  
ATOM    458  C   THR A 257       2.933  61.800  -3.045  1.00 35.98           C  
ATOM    459  O   THR A 257       2.466  62.921  -3.214  1.00 37.18           O  
ATOM    460  CB  THR A 257       4.654  60.960  -4.621  1.00 33.83           C  
ATOM    461  OG1 THR A 257       6.048  60.730  -4.826  1.00 34.41           O  
ATOM    462  CG2 THR A 257       4.161  61.912  -5.693  1.00 31.71           C  
ATOM    463  N   LYS A 258       2.182  60.759  -2.700  1.00 36.92           N  
ATOM    464  CA  LYS A 258       0.742  60.919  -2.500  1.00 39.18           C  
ATOM    465  C   LYS A 258       0.437  62.014  -1.504  1.00 39.84           C  
ATOM    466  O   LYS A 258      -0.540  62.739  -1.655  1.00 40.19           O  
ATOM    467  CB  LYS A 258       0.098  59.631  -1.978  1.00 39.82           C  
ATOM    468  CG  LYS A 258      -0.279  58.610  -3.042  1.00 40.33           C  
ATOM    469  CD  LYS A 258      -0.886  57.376  -2.370  1.00 42.84           C  
ATOM    470  CE  LYS A 258      -1.171  56.283  -3.373  1.00 43.69           C  
ATOM    471  NZ  LYS A 258      -1.527  54.996  -2.712  1.00 46.90           N  
ATOM    472  N   GLU A 259       1.285  62.130  -0.484  1.00 40.98           N  
ATOM    473  CA  GLU A 259       1.085  63.119   0.569  1.00 40.85           C  
ATOM    474  C   GLU A 259       1.606  64.516   0.283  1.00 40.53           C  
ATOM    475  O   GLU A 259       0.970  65.499   0.681  1.00 40.85           O  
ATOM    476  CB  GLU A 259       1.688  62.609   1.881  1.00 40.83           C  
ATOM    477  CG  GLU A 259       1.107  61.276   2.335  1.00 44.54           C  
ATOM    478  CD  GLU A 259      -0.411  61.315   2.480  1.00 49.57           C  
ATOM    479  OE1 GLU A 259      -1.080  60.316   2.133  1.00 50.44           O  
ATOM    480  OE2 GLU A 259      -0.942  62.348   2.948  1.00 55.11           O  
ATOM    481  N   ILE A 260       2.742  64.618  -0.408  1.00 38.27           N  
ATOM    482  CA  ILE A 260       3.320  65.932  -0.686  1.00 36.42           C  
ATOM    483  C   ILE A 260       2.736  66.608  -1.927  1.00 35.84           C  
ATOM    484  O   ILE A 260       2.663  67.822  -1.990  1.00 36.50           O  
ATOM    485  CB  ILE A 260       4.886  65.852  -0.790  1.00 34.70           C  
ATOM    486  CG1 ILE A 260       5.492  67.261  -0.838  1.00 34.94           C  
ATOM    487  CG2 ILE A 260       5.305  65.096  -2.020  1.00 33.90           C  
ATOM    488  CD1 ILE A 260       5.518  67.976   0.498  1.00 29.55           C  
ATOM    489  N   LYS A 261       2.315  65.821  -2.906  1.00 35.61           N  
ATOM    490  CA  LYS A 261       1.719  66.357  -4.128  1.00 36.69           C  
ATOM    491  C   LYS A 261       0.484  67.210  -3.780  1.00 37.61           C  
ATOM    492  O   LYS A 261      -0.366  66.798  -2.990  1.00 38.06           O  
ATOM    493  CB  LYS A 261       1.311  65.195  -5.034  1.00 39.49           C  
ATOM    494  CG  LYS A 261       0.755  65.575  -6.395  1.00 44.33           C  
ATOM    495  CD  LYS A 261       0.461  64.316  -7.235  1.00 47.72           C  
ATOM    496  CE  LYS A 261       1.731  63.489  -7.501  1.00 50.07           C  
ATOM    497  NZ  LYS A 261       1.527  62.302  -8.400  1.00 49.95           N  
ATOM    498  N   GLY A 262       0.382  68.398  -4.365  1.00 35.99           N  
ATOM    499  CA  GLY A 262      -0.749  69.256  -4.077  1.00 34.57           C  
ATOM    500  C   GLY A 262      -0.527  70.243  -2.943  1.00 35.28           C  
ATOM    501  O   GLY A 262      -1.259  71.220  -2.831  1.00 36.24           O  
ATOM    502  N   LEU A 263       0.468  70.001  -2.093  1.00 34.62           N  
ATOM    503  CA  LEU A 263       0.745  70.905  -0.979  1.00 32.94           C  
ATOM    504  C   LEU A 263       1.549  72.106  -1.426  1.00 34.40           C  
ATOM    505  O   LEU A 263       2.161  72.101  -2.488  1.00 35.21           O  
ATOM    506  CB  LEU A 263       1.499  70.183   0.145  1.00 30.15           C  
ATOM    507  CG  LEU A 263       0.707  69.072   0.850  1.00 30.03           C  
ATOM    508  CD1 LEU A 263       1.427  68.674   2.129  1.00 26.15           C  
ATOM    509  CD2 LEU A 263      -0.716  69.556   1.168  1.00 24.68           C  
ATOM    510  N   LYS A 264       1.538  73.150  -0.614  1.00 36.72           N  
ATOM    511  CA  LYS A 264       2.281  74.355  -0.945  1.00 36.84           C  
ATOM    512  C   LYS A 264       3.528  74.416  -0.072  1.00 36.35           C  
ATOM    513  O   LYS A 264       3.468  74.163   1.141  1.00 34.69           O  
ATOM    514  CB  LYS A 264       1.413  75.613  -0.726  1.00 36.50           C  
ATOM    515  CG  LYS A 264       2.086  76.912  -1.188  1.00 39.15           C  
ATOM    516  CD  LYS A 264       1.297  78.186  -0.825  1.00 41.11           C  
ATOM    517  CE  LYS A 264      -0.021  78.306  -1.604  1.00 42.74           C  
ATOM    518  NZ  LYS A 264      -0.658  79.673  -1.558  1.00 40.69           N  
ATOM    519  N   VAL A 265       4.662  74.727  -0.692  1.00 34.35           N  
ATOM    520  CA  VAL A 265       5.898  74.841   0.063  1.00 34.05           C  
ATOM    521  C   VAL A 265       6.580  76.193  -0.136  1.00 34.02           C  
ATOM    522  O   VAL A 265       6.414  76.844  -1.162  1.00 32.33           O  
ATOM    523  CB  VAL A 265       6.907  73.715  -0.300  1.00 31.37           C  
ATOM    524  CG1 VAL A 265       6.298  72.364   0.006  1.00 30.84           C  
ATOM    525  CG2 VAL A 265       7.330  73.821  -1.754  1.00 27.58           C  
ATOM    526  N   GLU A 266       7.342  76.601   0.867  1.00 35.53           N  
ATOM    527  CA  GLU A 266       8.086  77.848   0.817  1.00 39.60           C  
ATOM    528  C   GLU A 266       9.567  77.516   0.928  1.00 39.89           C  
ATOM    529  O   GLU A 266       9.978  76.726   1.771  1.00 41.19           O  
ATOM    530  CB  GLU A 266       7.679  78.773   1.964  1.00 42.10           C  
ATOM    531  CG  GLU A 266       7.721  78.116   3.332  1.00 45.22           C  
ATOM    532  CD  GLU A 266       7.809  79.139   4.451  1.00 49.16           C  
ATOM    533  OE1 GLU A 266       7.078  80.155   4.385  1.00 49.57           O  
ATOM    534  OE2 GLU A 266       8.604  78.920   5.399  1.00 49.55           O  
ATOM    535  N   VAL A 267      10.351  78.123   0.055  1.00 41.19           N  
ATOM    536  CA  VAL A 267      11.795  77.932  -0.003  1.00 44.83           C  
ATOM    537  C   VAL A 267      12.503  78.556   1.207  1.00 45.96           C  
ATOM    538  O   VAL A 267      12.061  79.582   1.721  1.00 46.48           O  
ATOM    539  CB  VAL A 267      12.316  78.551  -1.313  1.00 46.27           C  
ATOM    540  CG1 VAL A 267      13.526  79.401  -1.056  1.00 47.47           C  
ATOM    541  CG2 VAL A 267      12.600  77.450  -2.316  1.00 47.94           C  
ATOM    542  N   THR A 268      13.604  77.951   1.651  1.00 47.09           N  
ATOM    543  CA  THR A 268      14.330  78.457   2.818  1.00 49.86           C  
ATOM    544  C   THR A 268      15.825  78.658   2.638  1.00 51.47           C  
ATOM    545  O   THR A 268      16.568  78.597   3.620  1.00 52.04           O  
ATOM    546  CB  THR A 268      14.208  77.512   4.006  1.00 51.09           C  
ATOM    547  OG1 THR A 268      15.065  76.380   3.794  1.00 53.44           O  
ATOM    548  CG2 THR A 268      12.777  77.048   4.177  1.00 51.58           C  
ATOM    549  N   HIS A 269      16.266  78.894   1.404  1.00 53.23           N  
ATOM    550  CA  HIS A 269      17.688  79.070   1.100  1.00 52.25           C  
ATOM    551  C   HIS A 269      17.956  80.396   0.384  1.00 52.06           C  
ATOM    552  O   HIS A 269      19.003  80.576  -0.226  1.00 50.70           O  
ATOM    553  CB  HIS A 269      18.170  77.907   0.218  1.00 53.16           C  
ATOM    554  CG  HIS A 269      17.550  77.887  -1.149  1.00 53.97           C  
ATOM    555  ND1 HIS A 269      16.195  77.735  -1.352  1.00 52.44           N  
ATOM    556  CD2 HIS A 269      18.095  78.059  -2.379  1.00 54.16           C  
ATOM    557  CE1 HIS A 269      15.931  77.818  -2.644  1.00 53.10           C  
ATOM    558  NE2 HIS A 269      17.066  78.015  -3.290  1.00 54.59           N  
ATOM    559  N   CYS A 270      17.002  81.316   0.457  1.00 52.59           N  
ATOM    560  CA  CYS A 270      17.137  82.608  -0.196  1.00 52.99           C  
ATOM    561  C   CYS A 270      16.817  83.740   0.767  1.00 53.51           C  
ATOM    562  O   CYS A 270      16.180  84.729   0.398  1.00 52.59           O  
ATOM    563  CB  CYS A 270      16.196  82.688  -1.394  1.00 53.68           C  
ATOM    564  SG  CYS A 270      16.507  81.460  -2.663  1.00 56.70           S  
ATOM    565  N   GLY A 271      17.253  83.582   2.009  1.00 54.32           N  
ATOM    566  CA  GLY A 271      17.008  84.607   2.999  1.00 57.28           C  
ATOM    567  C   GLY A 271      15.540  84.940   3.186  1.00 59.47           C  
ATOM    568  O   GLY A 271      14.731  84.072   3.527  1.00 60.75           O  
ATOM    569  N   GLN A 272      15.187  86.201   2.958  1.00 60.30           N  
ATOM    570  CA  GLN A 272      13.812  86.639   3.143  1.00 60.12           C  
ATOM    571  C   GLN A 272      12.920  86.477   1.929  1.00 58.86           C  
ATOM    572  O   GLN A 272      11.722  86.785   1.963  1.00 58.05           O  
ATOM    573  CB  GLN A 272      13.793  88.085   3.633  1.00 62.43           C  
ATOM    574  CG  GLN A 272      14.120  88.188   5.108  1.00 64.30           C  
ATOM    575  CD  GLN A 272      13.328  87.183   5.936  1.00 65.22           C  
ATOM    576  OE1 GLN A 272      12.095  87.263   6.030  1.00 65.19           O  
ATOM    577  NE2 GLN A 272      14.037  86.221   6.533  1.00 64.57           N  
HETATM  578  N   MSE A 273      13.501  85.988   0.848  1.00 57.23           N  
HETATM  579  CA  MSE A 273      12.708  85.763  -0.340  1.00 57.67           C  
HETATM  580  C   MSE A 273      12.217  84.306  -0.243  1.00 56.67           C  
HETATM  581  O   MSE A 273      12.772  83.394  -0.872  1.00 55.79           O  
HETATM  582  CB  MSE A 273      13.561  85.972  -1.581  1.00 59.17           C  
HETATM  583  CG  MSE A 273      12.788  85.929  -2.867  1.00 62.00           C  
HETATM  584 SE   MSE A 273      14.010  85.464  -4.307  1.00 72.10          SE  
HETATM  585  CE  MSE A 273      13.545  86.793  -5.570  1.00 67.31           C  
ATOM    586  N   LYS A 274      11.194  84.095   0.582  1.00 53.18           N  
ATOM    587  CA  LYS A 274      10.635  82.764   0.768  1.00 51.10           C  
ATOM    588  C   LYS A 274       9.573  82.479  -0.296  1.00 48.80           C  
ATOM    589  O   LYS A 274       8.377  82.509  -0.025  1.00 47.43           O  
ATOM    590  CB  LYS A 274      10.030  82.658   2.161  1.00 51.57           C  
ATOM    591  CG  LYS A 274      11.005  82.952   3.285  1.00 52.24           C  
ATOM    592  CD  LYS A 274      10.349  82.612   4.609  1.00 55.19           C  
ATOM    593  CE  LYS A 274      11.262  82.842   5.788  1.00 56.33           C  
ATOM    594  NZ  LYS A 274      10.566  82.490   7.057  1.00 55.48           N  
ATOM    595  N   ARG A 275      10.029  82.208  -1.512  1.00 46.76           N  
ATOM    596  CA  ARG A 275       9.136  81.944  -2.622  1.00 45.13           C  
ATOM    597  C   ARG A 275       8.286  80.707  -2.346  1.00 45.49           C  
ATOM    598  O   ARG A 275       8.767  79.712  -1.796  1.00 44.92           O  
ATOM    599  CB  ARG A 275       9.954  81.763  -3.895  1.00 43.79           C  
ATOM    600  CG  ARG A 275       9.177  82.004  -5.172  1.00 41.93           C  
ATOM    601  CD  ARG A 275      10.052  81.733  -6.375  1.00 39.69           C  
ATOM    602  NE  ARG A 275       9.329  81.880  -7.635  1.00 40.75           N  
ATOM    603  CZ  ARG A 275       9.904  81.816  -8.830  1.00 40.74           C  
ATOM    604  NH1 ARG A 275      11.204  81.602  -8.933  1.00 42.23           N  
ATOM    605  NH2 ARG A 275       9.185  81.980  -9.924  1.00 42.52           N  
ATOM    606  N   LYS A 276       7.015  80.780  -2.718  1.00 44.81           N  
ATOM    607  CA  LYS A 276       6.098  79.672  -2.494  1.00 43.59           C  
ATOM    608  C   LYS A 276       5.870  78.937  -3.798  1.00 42.72           C  
ATOM    609  O   LYS A 276       5.656  79.565  -4.838  1.00 44.14           O  
ATOM    610  CB  LYS A 276       4.762  80.190  -1.965  1.00 43.91           C  
ATOM    611  CG  LYS A 276       4.861  81.037  -0.714  1.00 46.17           C  
ATOM    612  CD  LYS A 276       3.564  81.810  -0.485  1.00 48.18           C  
ATOM    613  CE  LYS A 276       3.757  82.948   0.519  1.00 51.64           C  
ATOM    614  NZ  LYS A 276       2.685  83.998   0.436  1.00 51.87           N  
ATOM    615  N   TYR A 277       5.936  77.611  -3.746  1.00 41.26           N  
ATOM    616  CA  TYR A 277       5.710  76.780  -4.930  1.00 40.92           C  
ATOM    617  C   TYR A 277       4.611  75.765  -4.652  1.00 40.77           C  
ATOM    618  O   TYR A 277       4.291  75.483  -3.498  1.00 41.68           O  
ATOM    619  CB  TYR A 277       6.975  76.016  -5.327  1.00 39.64           C  
ATOM    620  CG  TYR A 277       8.162  76.881  -5.656  1.00 41.04           C  
ATOM    621  CD1 TYR A 277       8.985  77.376  -4.653  1.00 40.17           C  
ATOM    622  CD2 TYR A 277       8.460  77.211  -6.981  1.00 42.90           C  
ATOM    623  CE1 TYR A 277      10.073  78.173  -4.953  1.00 42.09           C  
ATOM    624  CE2 TYR A 277       9.549  78.008  -7.300  1.00 42.30           C  
ATOM    625  CZ  TYR A 277      10.357  78.488  -6.283  1.00 44.67           C  
ATOM    626  OH  TYR A 277      11.462  79.270  -6.596  1.00 46.69           O  
ATOM    627  N   ARG A 278       4.033  75.223  -5.717  1.00 40.54           N  
ATOM    628  CA  ARG A 278       2.992  74.205  -5.601  1.00 39.18           C  
ATOM    629  C   ARG A 278       3.660  72.890  -5.984  1.00 38.43           C  
ATOM    630  O   ARG A 278       4.191  72.759  -7.075  1.00 41.19           O  
ATOM    631  CB  ARG A 278       1.846  74.515  -6.565  1.00 38.42           C  
ATOM    632  CG  ARG A 278       0.769  73.441  -6.642  1.00 39.72           C  
ATOM    633  CD  ARG A 278       0.029  73.258  -5.309  1.00 37.57           C  
ATOM    634  NE  ARG A 278      -0.711  74.450  -4.926  1.00 35.12           N  
ATOM    635  CZ  ARG A 278      -1.312  74.607  -3.751  1.00 36.62           C  
ATOM    636  NH1 ARG A 278      -1.255  73.641  -2.848  1.00 33.94           N  
ATOM    637  NH2 ARG A 278      -1.961  75.732  -3.472  1.00 33.90           N  
ATOM    638  N   VAL A 279       3.680  71.924  -5.086  1.00 38.07           N  
ATOM    639  CA  VAL A 279       4.307  70.657  -5.422  1.00 38.41           C  
ATOM    640  C   VAL A 279       3.429  69.959  -6.446  1.00 40.14           C  
ATOM    641  O   VAL A 279       2.220  69.845  -6.264  1.00 38.88           O  
ATOM    642  CB  VAL A 279       4.434  69.761  -4.201  1.00 37.82           C  
ATOM    643  CG1 VAL A 279       5.333  68.593  -4.524  1.00 37.50           C  
ATOM    644  CG2 VAL A 279       4.981  70.549  -3.042  1.00 36.66           C  
ATOM    645  N   CYS A 280       4.020  69.511  -7.544  1.00 42.74           N  
ATOM    646  CA  CYS A 280       3.220  68.832  -8.553  1.00 45.77           C  
ATOM    647  C   CYS A 280       3.643  67.378  -8.715  1.00 46.23           C  
ATOM    648  O   CYS A 280       2.955  66.600  -9.374  1.00 47.75           O  
ATOM    649  CB  CYS A 280       3.294  69.569  -9.905  1.00 45.77           C  
ATOM    650  SG  CYS A 280       4.862  69.467 -10.802  1.00 51.59           S  
ATOM    651  N   ASN A 281       4.754  67.008  -8.087  1.00 45.95           N  
ATOM    652  CA  ASN A 281       5.254  65.650  -8.190  1.00 46.07           C  
ATOM    653  C   ASN A 281       6.583  65.539  -7.450  1.00 45.90           C  
ATOM    654  O   ASN A 281       7.144  66.545  -7.013  1.00 45.97           O  
ATOM    655  CB  ASN A 281       5.448  65.315  -9.669  1.00 47.16           C  
ATOM    656  CG  ASN A 281       5.453  63.817  -9.959  1.00 48.55           C  
ATOM    657  OD1 ASN A 281       5.388  63.421 -11.118  1.00 50.60           O  
ATOM    658  ND2 ASN A 281       5.533  62.988  -8.924  1.00 48.41           N  
ATOM    659  N   VAL A 282       7.076  64.314  -7.311  1.00 44.84           N  
ATOM    660  CA  VAL A 282       8.348  64.054  -6.657  1.00 46.56           C  
ATOM    661  C   VAL A 282       9.218  63.366  -7.698  1.00 47.96           C  
ATOM    662  O   VAL A 282       8.716  62.546  -8.469  1.00 50.44           O  
ATOM    663  CB  VAL A 282       8.167  63.121  -5.451  1.00 46.75           C  
ATOM    664  CG1 VAL A 282       9.500  62.816  -4.807  1.00 47.32           C  
ATOM    665  CG2 VAL A 282       7.245  63.760  -4.450  1.00 48.18           C  
ATOM    666  N   THR A 283      10.506  63.699  -7.752  1.00 48.48           N  
ATOM    667  CA  THR A 283      11.384  63.058  -8.740  1.00 48.22           C  
ATOM    668  C   THR A 283      11.688  61.612  -8.365  1.00 48.56           C  
ATOM    669  O   THR A 283      11.519  61.217  -7.210  1.00 48.55           O  
ATOM    670  CB  THR A 283      12.751  63.791  -8.891  1.00 46.35           C  
ATOM    671  OG1 THR A 283      13.442  63.823  -7.634  1.00 45.49           O  
ATOM    672  CG2 THR A 283      12.544  65.182  -9.393  1.00 45.78           C  
ATOM    673  N   ARG A 284      12.133  60.825  -9.342  1.00 49.97           N  
ATOM    674  CA  ARG A 284      12.508  59.430  -9.082  1.00 50.79           C  
ATOM    675  C   ARG A 284      14.001  59.403  -8.805  1.00 51.32           C  
ATOM    676  O   ARG A 284      14.487  58.612  -8.011  1.00 51.85           O  
ATOM    677  CB  ARG A 284      12.223  58.527 -10.288  1.00 49.87           C  
ATOM    678  CG  ARG A 284      10.774  58.158 -10.483  1.00 48.65           C  
ATOM    679  CD  ARG A 284      10.651  56.986 -11.437  1.00 48.71           C  
ATOM    680  NE  ARG A 284       9.255  56.674 -11.728  1.00 48.01           N  
ATOM    681  CZ  ARG A 284       8.861  55.661 -12.489  1.00 46.28           C  
ATOM    682  NH1 ARG A 284       9.758  54.854 -13.042  1.00 45.82           N  
ATOM    683  NH2 ARG A 284       7.567  55.454 -12.692  1.00 45.59           N  
ATOM    684  N   ARG A 285      14.721  60.288  -9.478  1.00 53.43           N  
ATOM    685  CA  ARG A 285      16.164  60.392  -9.326  1.00 54.63           C  
ATOM    686  C   ARG A 285      16.498  61.266  -8.125  1.00 54.20           C  
ATOM    687  O   ARG A 285      15.755  62.182  -7.790  1.00 54.42           O  
ATOM    688  CB  ARG A 285      16.755  60.991 -10.593  1.00 56.34           C  
ATOM    689  CG  ARG A 285      16.110  60.442 -11.864  1.00 58.44           C  
ATOM    690  CD  ARG A 285      17.065  60.568 -13.016  1.00 61.85           C  
ATOM    691  NE  ARG A 285      18.407  60.212 -12.557  1.00 66.50           N  
ATOM    692  CZ  ARG A 285      19.440  59.970 -13.355  1.00 67.35           C  
ATOM    693  NH1 ARG A 285      19.286  60.041 -14.672  1.00 67.08           N  
ATOM    694  NH2 ARG A 285      20.627  59.671 -12.830  1.00 66.98           N  
ATOM    695  N   PRO A 286      17.624  60.994  -7.456  1.00 54.09           N  
ATOM    696  CA  PRO A 286      17.982  61.802  -6.296  1.00 53.76           C  
ATOM    697  C   PRO A 286      18.538  63.148  -6.721  1.00 55.01           C  
ATOM    698  O   PRO A 286      18.969  63.323  -7.865  1.00 54.56           O  
ATOM    699  CB  PRO A 286      19.040  60.956  -5.595  1.00 53.43           C  
ATOM    700  CG  PRO A 286      18.834  59.580  -6.138  1.00 53.10           C  
ATOM    701  CD  PRO A 286      18.540  59.857  -7.576  1.00 53.68           C  
ATOM    702  N   ALA A 287      18.520  64.095  -5.788  1.00 55.18           N  
ATOM    703  CA  ALA A 287      19.038  65.426  -6.033  1.00 55.15           C  
ATOM    704  C   ALA A 287      20.431  65.301  -6.652  1.00 55.99           C  
ATOM    705  O   ALA A 287      20.817  66.091  -7.504  1.00 54.41           O  
ATOM    706  CB  ALA A 287      19.112  66.188  -4.731  1.00 55.55           C  
ATOM    707  N   SER A 288      21.182  64.292  -6.228  1.00 57.89           N  
ATOM    708  CA  SER A 288      22.524  64.091  -6.761  1.00 59.24           C  
ATOM    709  C   SER A 288      22.545  63.760  -8.258  1.00 61.02           C  
ATOM    710  O   SER A 288      23.573  63.944  -8.914  1.00 62.09           O  
ATOM    711  CB  SER A 288      23.273  63.006  -5.961  1.00 58.75           C  
ATOM    712  OG  SER A 288      22.584  61.767  -5.910  1.00 58.84           O  
ATOM    713  N   HIS A 289      21.421  63.304  -8.812  1.00 61.32           N  
ATOM    714  CA  HIS A 289      21.389  62.968 -10.235  1.00 60.66           C  
ATOM    715  C   HIS A 289      20.325  63.661 -11.062  1.00 60.82           C  
ATOM    716  O   HIS A 289      20.476  63.796 -12.278  1.00 60.46           O  
ATOM    717  CB  HIS A 289      21.247  61.464 -10.409  1.00 61.07           C  
ATOM    718  CG  HIS A 289      22.301  60.683  -9.694  1.00 61.58           C  
ATOM    719  ND1 HIS A 289      22.462  60.737  -8.325  1.00 61.01           N  
ATOM    720  CD2 HIS A 289      23.267  59.856 -10.157  1.00 61.31           C  
ATOM    721  CE1 HIS A 289      23.486  59.978  -7.977  1.00 62.22           C  
ATOM    722  NE2 HIS A 289      23.993  59.434  -9.069  1.00 62.01           N  
ATOM    723  N   GLN A 290      19.246  64.095 -10.419  1.00 61.16           N  
ATOM    724  CA  GLN A 290      18.179  64.769 -11.153  1.00 61.13           C  
ATOM    725  C   GLN A 290      18.773  65.880 -12.002  1.00 62.60           C  
ATOM    726  O   GLN A 290      19.583  66.673 -11.526  1.00 62.99           O  
ATOM    727  CB  GLN A 290      17.138  65.355 -10.207  1.00 58.64           C  
ATOM    728  CG  GLN A 290      15.982  65.989 -10.949  1.00 57.67           C  
ATOM    729  CD  GLN A 290      15.276  65.017 -11.885  1.00 57.17           C  
ATOM    730  OE1 GLN A 290      14.532  65.428 -12.775  1.00 58.59           O  
ATOM    731  NE2 GLN A 290      15.495  63.729 -11.682  1.00 56.13           N  
ATOM    732  N   THR A 291      18.360  65.947 -13.258  1.00 63.03           N  
ATOM    733  CA  THR A 291      18.904  66.945 -14.148  1.00 64.30           C  
ATOM    734  C   THR A 291      17.864  67.833 -14.820  1.00 66.05           C  
ATOM    735  O   THR A 291      16.674  67.508 -14.859  1.00 65.87           O  
ATOM    736  CB  THR A 291      19.742  66.262 -15.224  1.00 63.60           C  
ATOM    737  OG1 THR A 291      20.187  67.234 -16.171  1.00 65.31           O  
ATOM    738  CG2 THR A 291      18.920  65.213 -15.934  1.00 64.80           C  
ATOM    739  N   PHE A 292      18.332  68.965 -15.340  1.00 67.57           N  
ATOM    740  CA  PHE A 292      17.475  69.913 -16.044  1.00 69.25           C  
ATOM    741  C   PHE A 292      18.275  70.710 -17.094  1.00 71.58           C  
ATOM    742  O   PHE A 292      19.511  70.680 -17.106  1.00 70.48           O  
ATOM    743  CB  PHE A 292      16.806  70.876 -15.052  1.00 67.00           C  
ATOM    744  CG  PHE A 292      17.773  71.745 -14.293  1.00 64.71           C  
ATOM    745  CD1 PHE A 292      18.579  71.210 -13.299  1.00 62.49           C  
ATOM    746  CD2 PHE A 292      17.874  73.103 -14.576  1.00 63.60           C  
ATOM    747  CE1 PHE A 292      19.466  72.010 -12.599  1.00 61.04           C  
ATOM    748  CE2 PHE A 292      18.759  73.909 -13.881  1.00 61.43           C  
ATOM    749  CZ  PHE A 292      19.556  73.359 -12.891  1.00 60.79           C  
ATOM    750  N   PRO A 293      17.570  71.414 -18.001  1.00 73.82           N  
ATOM    751  CA  PRO A 293      18.175  72.227 -19.064  1.00 75.39           C  
ATOM    752  C   PRO A 293      18.780  73.516 -18.509  1.00 77.08           C  
ATOM    753  O   PRO A 293      18.075  74.516 -18.390  1.00 77.06           O  
ATOM    754  CB  PRO A 293      16.990  72.538 -19.988  1.00 75.07           C  
ATOM    755  CG  PRO A 293      15.993  71.470 -19.687  1.00 74.48           C  
ATOM    756  CD  PRO A 293      16.113  71.318 -18.199  1.00 74.83           C  
ATOM    757  N   LEU A 294      20.073  73.499 -18.181  1.00 79.35           N  
ATOM    758  CA  LEU A 294      20.746  74.684 -17.632  1.00 81.18           C  
ATOM    759  C   LEU A 294      21.474  75.528 -18.684  1.00 82.52           C  
ATOM    760  O   LEU A 294      22.262  75.004 -19.475  1.00 83.90           O  
ATOM    761  CB  LEU A 294      21.744  74.271 -16.548  1.00 81.04           C  
ATOM    762  CG  LEU A 294      22.543  75.424 -15.927  1.00 81.76           C  
ATOM    763  CD1 LEU A 294      21.589  76.476 -15.373  1.00 81.25           C  
ATOM    764  CD2 LEU A 294      23.452  74.892 -14.822  1.00 81.51           C  
ATOM    765  N   GLN A 295      21.220  76.836 -18.681  1.00 82.65           N  
ATOM    766  CA  GLN A 295      21.859  77.743 -19.638  1.00 83.13           C  
ATOM    767  C   GLN A 295      23.185  78.292 -19.110  1.00 83.24           C  
ATOM    768  O   GLN A 295      23.708  79.288 -19.614  1.00 82.66           O  
ATOM    769  CB  GLN A 295      20.923  78.907 -19.972  1.00 83.01           C  
ATOM    770  N   VAL A 302      23.181  73.373 -22.175  1.00 99.12           N  
ATOM    771  CA  VAL A 302      23.697  72.217 -21.450  1.00100.05           C  
ATOM    772  C   VAL A 302      22.669  71.726 -20.434  1.00100.15           C  
ATOM    773  O   VAL A 302      21.506  72.133 -20.474  1.00100.21           O  
ATOM    774  CB  VAL A 302      25.010  72.557 -20.691  1.00100.50           C  
ATOM    775  CG1 VAL A 302      25.967  73.298 -21.613  1.00101.02           C  
ATOM    776  CG2 VAL A 302      24.710  73.381 -19.444  1.00100.13           C  
ATOM    777  N   GLU A 303      23.106  70.850 -19.530  1.00 99.51           N  
ATOM    778  CA  GLU A 303      22.238  70.305 -18.490  1.00 98.58           C  
ATOM    779  C   GLU A 303      23.032  70.018 -17.226  1.00 97.48           C  
ATOM    780  O   GLU A 303      24.102  69.411 -17.284  1.00 97.60           O  
ATOM    781  CB  GLU A 303      21.552  69.029 -18.979  1.00 99.02           C  
ATOM    782  CG  GLU A 303      20.545  69.288 -20.087  1.00101.14           C  
ATOM    783  CD  GLU A 303      19.585  68.134 -20.301  1.00102.36           C  
ATOM    784  OE1 GLU A 303      18.867  67.765 -19.344  1.00103.11           O  
ATOM    785  OE2 GLU A 303      19.545  67.602 -21.430  1.00102.80           O  
ATOM    786  N   CYS A 304      22.500  70.452 -16.083  1.00 95.70           N  
ATOM    787  CA  CYS A 304      23.178  70.260 -14.801  1.00 93.21           C  
ATOM    788  C   CYS A 304      22.427  69.401 -13.786  1.00 90.95           C  
ATOM    789  O   CYS A 304      21.222  69.172 -13.905  1.00 90.56           O  
ATOM    790  CB  CYS A 304      23.480  71.622 -14.165  1.00 93.17           C  
ATOM    791  SG  CYS A 304      24.395  71.540 -12.596  1.00 95.28           S  
ATOM    792  N   THR A 305      23.169  68.930 -12.788  1.00 88.08           N  
ATOM    793  CA  THR A 305      22.623  68.125 -11.713  1.00 86.38           C  
ATOM    794  C   THR A 305      22.270  69.138 -10.609  1.00 86.73           C  
ATOM    795  O   THR A 305      23.079  70.014 -10.287  1.00 86.77           O  
ATOM    796  CB  THR A 305      23.675  67.092 -11.223  1.00 85.38           C  
ATOM    797  OG1 THR A 305      23.020  65.864 -10.894  1.00 86.83           O  
ATOM    798  CG2 THR A 305      24.414  67.588  -9.997  1.00 84.07           C  
ATOM    799  N   VAL A 306      21.065  69.029 -10.043  1.00 86.11           N  
ATOM    800  CA  VAL A 306      20.611  69.969  -9.014  1.00 85.10           C  
ATOM    801  C   VAL A 306      21.512  70.093  -7.792  1.00 83.98           C  
ATOM    802  O   VAL A 306      21.550  71.143  -7.158  1.00 84.38           O  
ATOM    803  CB  VAL A 306      19.161  69.656  -8.526  1.00 84.95           C  
ATOM    804  CG1 VAL A 306      18.216  69.586  -9.709  1.00 84.71           C  
ATOM    805  CG2 VAL A 306      19.128  68.375  -7.735  1.00 85.03           C  
ATOM    806  N   ALA A 307      22.233  69.034  -7.452  1.00 82.88           N  
ATOM    807  CA  ALA A 307      23.125  69.102  -6.304  1.00 83.18           C  
ATOM    808  C   ALA A 307      24.189  70.157  -6.596  1.00 83.49           C  
ATOM    809  O   ALA A 307      24.426  71.060  -5.790  1.00 83.17           O  
ATOM    810  CB  ALA A 307      23.774  67.749  -6.060  1.00 83.44           C  
ATOM    811  N   GLN A 308      24.817  70.034  -7.762  1.00 83.76           N  
ATOM    812  CA  GLN A 308      25.852  70.965  -8.195  1.00 84.35           C  
ATOM    813  C   GLN A 308      25.294  72.376  -8.232  1.00 82.99           C  
ATOM    814  O   GLN A 308      25.872  73.295  -7.652  1.00 83.45           O  
ATOM    815  CB  GLN A 308      26.375  70.572  -9.582  1.00 86.81           C  
ATOM    816  CG  GLN A 308      27.406  69.435  -9.570  1.00 90.08           C  
ATOM    817  CD  GLN A 308      27.411  68.611 -10.864  1.00 91.43           C  
ATOM    818  OE1 GLN A 308      27.386  69.160 -11.969  1.00 92.61           O  
ATOM    819  NE2 GLN A 308      27.454  67.286 -10.724  1.00 90.71           N  
ATOM    820  N   TYR A 309      24.166  72.543  -8.913  1.00 80.22           N  
ATOM    821  CA  TYR A 309      23.529  73.846  -9.013  1.00 77.61           C  
ATOM    822  C   TYR A 309      23.423  74.522  -7.640  1.00 77.68           C  
ATOM    823  O   TYR A 309      23.781  75.683  -7.490  1.00 77.96           O  
ATOM    824  CB  TYR A 309      22.140  73.691  -9.621  1.00 74.78           C  
ATOM    825  CG  TYR A 309      21.372  74.980  -9.770  1.00 72.17           C  
ATOM    826  CD1 TYR A 309      21.371  75.681 -10.974  1.00 70.94           C  
ATOM    827  CD2 TYR A 309      20.626  75.489  -8.713  1.00 71.64           C  
ATOM    828  CE1 TYR A 309      20.637  76.857 -11.122  1.00 69.86           C  
ATOM    829  CE2 TYR A 309      19.892  76.661  -8.849  1.00 71.07           C  
ATOM    830  CZ  TYR A 309      19.901  77.337 -10.054  1.00 70.43           C  
ATOM    831  OH  TYR A 309      19.162  78.484 -10.182  1.00 70.17           O  
ATOM    832  N   PHE A 310      22.945  73.802  -6.632  1.00 77.35           N  
ATOM    833  CA  PHE A 310      22.809  74.400  -5.308  1.00 77.76           C  
ATOM    834  C   PHE A 310      24.126  74.621  -4.574  1.00 78.75           C  
ATOM    835  O   PHE A 310      24.172  75.340  -3.576  1.00 77.89           O  
ATOM    836  CB  PHE A 310      21.845  73.577  -4.441  1.00 75.57           C  
ATOM    837  CG  PHE A 310      20.398  73.902  -4.685  1.00 74.03           C  
ATOM    838  CD1 PHE A 310      19.797  73.600  -5.902  1.00 72.63           C  
ATOM    839  CD2 PHE A 310      19.652  74.577  -3.721  1.00 73.38           C  
ATOM    840  CE1 PHE A 310      18.480  73.971  -6.157  1.00 72.06           C  
ATOM    841  CE2 PHE A 310      18.330  74.954  -3.971  1.00 71.33           C  
ATOM    842  CZ  PHE A 310      17.747  74.652  -5.189  1.00 71.39           C  
ATOM    843  N   LYS A 311      25.196  74.007  -5.069  1.00 80.34           N  
ATOM    844  CA  LYS A 311      26.519  74.164  -4.461  1.00 81.61           C  
ATOM    845  C   LYS A 311      27.284  75.222  -5.261  1.00 81.83           C  
ATOM    846  O   LYS A 311      28.219  75.853  -4.759  1.00 81.32           O  
ATOM    847  CB  LYS A 311      27.283  72.833  -4.489  1.00 82.03           C  
ATOM    848  CG  LYS A 311      28.532  72.776  -3.602  1.00 83.17           C  
ATOM    849  CD  LYS A 311      29.708  73.595  -4.146  1.00 83.50           C  
ATOM    850  CE  LYS A 311      30.917  73.521  -3.207  1.00 83.39           C  
ATOM    851  NZ  LYS A 311      32.044  74.388  -3.650  1.00 81.84           N  
ATOM    852  N   GLN A 312      26.867  75.415  -6.507  1.00 80.95           N  
ATOM    853  CA  GLN A 312      27.507  76.383  -7.373  1.00 81.19           C  
ATOM    854  C   GLN A 312      26.808  77.741  -7.309  1.00 79.85           C  
ATOM    855  O   GLN A 312      27.472  78.775  -7.237  1.00 80.65           O  
ATOM    856  CB  GLN A 312      27.548  75.848  -8.815  1.00 84.03           C  
ATOM    857  CG  GLN A 312      28.201  74.450  -8.928  1.00 88.18           C  
ATOM    858  CD  GLN A 312      28.431  73.971 -10.367  1.00 90.31           C  
ATOM    859  OE1 GLN A 312      27.534  74.028 -11.214  1.00 91.64           O  
ATOM    860  NE2 GLN A 312      29.639  73.481 -10.639  1.00 91.01           N  
ATOM    861  N   LYS A 313      25.477  77.744  -7.306  1.00 78.02           N  
ATOM    862  CA  LYS A 313      24.724  78.998  -7.256  1.00 74.41           C  
ATOM    863  C   LYS A 313      24.398  79.498  -5.855  1.00 71.90           C  
ATOM    864  O   LYS A 313      24.107  80.677  -5.680  1.00 71.96           O  
ATOM    865  CB  LYS A 313      23.423  78.893  -8.064  1.00 74.35           C  
ATOM    866  CG  LYS A 313      22.553  80.154  -7.974  1.00 74.55           C  
ATOM    867  CD  LYS A 313      21.539  80.264  -9.102  1.00 73.08           C  
ATOM    868  CE  LYS A 313      20.826  81.606  -9.032  1.00 72.98           C  
ATOM    869  NZ  LYS A 313      20.133  81.967 -10.310  1.00 73.07           N  
ATOM    870  N   TYR A 314      24.446  78.619  -4.861  1.00 69.21           N  
ATOM    871  CA  TYR A 314      24.143  79.018  -3.485  1.00 66.32           C  
ATOM    872  C   TYR A 314      25.229  78.540  -2.555  1.00 65.78           C  
ATOM    873  O   TYR A 314      25.195  78.816  -1.358  1.00 65.26           O  
ATOM    874  CB  TYR A 314      22.801  78.428  -3.030  1.00 64.36           C  
ATOM    875  CG  TYR A 314      21.627  78.972  -3.799  1.00 61.12           C  
ATOM    876  CD1 TYR A 314      21.243  80.304  -3.662  1.00 59.02           C  
ATOM    877  CD2 TYR A 314      20.942  78.177  -4.715  1.00 59.32           C  
ATOM    878  CE1 TYR A 314      20.214  80.837  -4.420  1.00 57.97           C  
ATOM    879  CE2 TYR A 314      19.908  78.701  -5.481  1.00 58.37           C  
ATOM    880  CZ  TYR A 314      19.555  80.032  -5.327  1.00 57.57           C  
ATOM    881  OH  TYR A 314      18.555  80.568  -6.087  1.00 56.53           O  
ATOM    882  N   ASN A 315      26.192  77.822  -3.118  1.00 66.30           N  
ATOM    883  CA  ASN A 315      27.293  77.270  -2.345  1.00 66.56           C  
ATOM    884  C   ASN A 315      26.682  76.519  -1.173  1.00 66.64           C  
ATOM    885  O   ASN A 315      26.962  76.806  -0.009  1.00 66.38           O  
ATOM    886  CB  ASN A 315      28.223  78.386  -1.855  1.00 66.91           C  
ATOM    887  CG  ASN A 315      29.580  77.862  -1.420  1.00 67.63           C  
ATOM    888  OD1 ASN A 315      29.774  77.464  -0.270  1.00 67.31           O  
ATOM    889  ND2 ASN A 315      30.527  77.844  -2.352  1.00 68.78           N  
ATOM    890  N   LEU A 316      25.823  75.560  -1.505  1.00 67.43           N  
ATOM    891  CA  LEU A 316      25.144  74.744  -0.512  1.00 68.03           C  
ATOM    892  C   LEU A 316      25.341  73.268  -0.795  1.00 68.92           C  
ATOM    893  O   LEU A 316      24.702  72.703  -1.680  1.00 70.84           O  
ATOM    894  CB  LEU A 316      23.643  75.075  -0.488  1.00 67.55           C  
ATOM    895  CG  LEU A 316      22.683  74.173   0.297  1.00 65.95           C  
ATOM    896  CD1 LEU A 316      23.205  73.939   1.696  1.00 66.50           C  
ATOM    897  CD2 LEU A 316      21.311  74.817   0.342  1.00 64.86           C  
ATOM    898  N   GLN A 317      26.256  72.647  -0.064  1.00 69.26           N  
ATOM    899  CA  GLN A 317      26.484  71.228  -0.239  1.00 69.71           C  
ATOM    900  C   GLN A 317      25.260  70.603   0.398  1.00 68.34           C  
ATOM    901  O   GLN A 317      25.060  70.713   1.611  1.00 67.81           O  
ATOM    902  CB  GLN A 317      27.754  70.781   0.497  1.00 72.28           C  
ATOM    903  CG  GLN A 317      29.036  70.785  -0.350  1.00 76.58           C  
ATOM    904  CD  GLN A 317      29.030  69.732  -1.461  1.00 79.18           C  
ATOM    905  OE1 GLN A 317      28.370  69.898  -2.495  1.00 80.48           O  
ATOM    906  NE2 GLN A 317      29.762  68.640  -1.244  1.00 79.01           N  
ATOM    907  N   LEU A 318      24.427  69.968  -0.416  1.00 66.20           N  
ATOM    908  CA  LEU A 318      23.220  69.350   0.112  1.00 65.40           C  
ATOM    909  C   LEU A 318      23.492  68.329   1.216  1.00 64.33           C  
ATOM    910  O   LEU A 318      24.439  67.542   1.139  1.00 65.02           O  
ATOM    911  CB  LEU A 318      22.427  68.711  -1.028  1.00 64.99           C  
ATOM    912  CG  LEU A 318      21.642  69.727  -1.853  1.00 64.46           C  
ATOM    913  CD1 LEU A 318      21.191  69.111  -3.159  1.00 64.45           C  
ATOM    914  CD2 LEU A 318      20.455  70.209  -1.034  1.00 64.23           C  
ATOM    915  N   LYS A 319      22.656  68.359   2.248  1.00 62.84           N  
ATOM    916  CA  LYS A 319      22.782  67.445   3.376  1.00 62.31           C  
ATOM    917  C   LYS A 319      22.209  66.061   3.020  1.00 61.58           C  
ATOM    918  O   LYS A 319      22.622  65.053   3.587  1.00 61.98           O  
ATOM    919  CB  LYS A 319      22.041  68.025   4.590  1.00 64.08           C  
ATOM    920  CG  LYS A 319      22.621  67.653   5.962  1.00 65.23           C  
ATOM    921  CD  LYS A 319      21.631  67.950   7.104  1.00 67.86           C  
ATOM    922  CE  LYS A 319      21.128  69.397   7.084  1.00 70.56           C  
ATOM    923  NZ  LYS A 319      19.984  69.642   8.019  1.00 71.43           N  
ATOM    924  N   TYR A 320      21.259  66.025   2.083  1.00 60.48           N  
ATOM    925  CA  TYR A 320      20.619  64.780   1.635  1.00 58.25           C  
ATOM    926  C   TYR A 320      20.571  64.661   0.107  1.00 57.45           C  
ATOM    927  O   TYR A 320      19.494  64.634  -0.498  1.00 55.54           O  
ATOM    928  CB  TYR A 320      19.190  64.682   2.165  1.00 57.10           C  
ATOM    929  CG  TYR A 320      19.074  64.814   3.658  1.00 56.95           C  
ATOM    930  CD1 TYR A 320      18.950  66.070   4.259  1.00 57.04           C  
ATOM    931  CD2 TYR A 320      19.117  63.687   4.480  1.00 55.05           C  
ATOM    932  CE1 TYR A 320      18.873  66.198   5.637  1.00 55.90           C  
ATOM    933  CE2 TYR A 320      19.046  63.803   5.856  1.00 54.45           C  
ATOM    934  CZ  TYR A 320      18.925  65.060   6.428  1.00 56.46           C  
ATOM    935  OH  TYR A 320      18.865  65.181   7.794  1.00 58.32           O  
ATOM    936  N   PRO A 321      21.744  64.594  -0.539  1.00 56.56           N  
ATOM    937  CA  PRO A 321      21.791  64.477  -1.997  1.00 55.01           C  
ATOM    938  C   PRO A 321      21.155  63.172  -2.472  1.00 53.30           C  
ATOM    939  O   PRO A 321      20.794  63.033  -3.642  1.00 51.81           O  
ATOM    940  CB  PRO A 321      23.293  64.527  -2.298  1.00 54.22           C  
ATOM    941  CG  PRO A 321      23.835  65.344  -1.188  1.00 55.58           C  
ATOM    942  CD  PRO A 321      23.097  64.784   0.008  1.00 56.46           C  
ATOM    943  N   HIS A 322      21.019  62.220  -1.558  1.00 52.33           N  
ATOM    944  CA  HIS A 322      20.448  60.928  -1.903  1.00 53.52           C  
ATOM    945  C   HIS A 322      18.913  60.905  -2.001  1.00 52.85           C  
ATOM    946  O   HIS A 322      18.352  60.089  -2.735  1.00 53.35           O  
ATOM    947  CB  HIS A 322      20.954  59.874  -0.919  1.00 54.73           C  
ATOM    948  CG  HIS A 322      20.675  60.194   0.515  1.00 57.15           C  
ATOM    949  ND1 HIS A 322      19.514  59.808   1.152  1.00 58.07           N  
ATOM    950  CD2 HIS A 322      21.418  60.842   1.442  1.00 56.87           C  
ATOM    951  CE1 HIS A 322      19.557  60.200   2.414  1.00 58.11           C  
ATOM    952  NE2 HIS A 322      20.702  60.829   2.615  1.00 57.17           N  
ATOM    953  N   LEU A 323      18.242  61.798  -1.272  1.00 51.04           N  
ATOM    954  CA  LEU A 323      16.779  61.902  -1.307  1.00 46.45           C  
ATOM    955  C   LEU A 323      16.377  62.628  -2.606  1.00 45.20           C  
ATOM    956  O   LEU A 323      17.189  63.322  -3.219  1.00 44.74           O  
ATOM    957  CB  LEU A 323      16.283  62.682  -0.082  1.00 43.92           C  
ATOM    958  CG  LEU A 323      16.587  62.039   1.275  1.00 42.05           C  
ATOM    959  CD1 LEU A 323      16.193  62.974   2.402  1.00 40.92           C  
ATOM    960  CD2 LEU A 323      15.845  60.713   1.396  1.00 40.31           C  
ATOM    961  N   PRO A 324      15.119  62.480  -3.043  1.00 43.57           N  
ATOM    962  CA  PRO A 324      14.683  63.140  -4.275  1.00 43.17           C  
ATOM    963  C   PRO A 324      14.378  64.616  -4.116  1.00 43.27           C  
ATOM    964  O   PRO A 324      14.461  65.177  -3.028  1.00 42.91           O  
ATOM    965  CB  PRO A 324      13.415  62.370  -4.661  1.00 42.85           C  
ATOM    966  CG  PRO A 324      13.446  61.153  -3.819  1.00 42.67           C  
ATOM    967  CD  PRO A 324      14.065  61.594  -2.546  1.00 42.43           C  
ATOM    968  N   CYS A 325      13.984  65.222  -5.226  1.00 44.08           N  
ATOM    969  CA  CYS A 325      13.619  66.625  -5.269  1.00 44.83           C  
ATOM    970  C   CYS A 325      12.119  66.694  -5.507  1.00 44.34           C  
ATOM    971  O   CYS A 325      11.513  65.725  -5.984  1.00 43.13           O  
ATOM    972  CB  CYS A 325      14.325  67.324  -6.430  1.00 47.46           C  
ATOM    973  SG  CYS A 325      16.105  67.125  -6.418  1.00 54.85           S  
ATOM    974  N   LEU A 326      11.529  67.836  -5.164  1.00 43.24           N  
ATOM    975  CA  LEU A 326      10.107  68.056  -5.373  1.00 43.39           C  
ATOM    976  C   LEU A 326       9.985  68.826  -6.674  1.00 44.32           C  
ATOM    977  O   LEU A 326      10.633  69.854  -6.839  1.00 46.17           O  
ATOM    978  CB  LEU A 326       9.507  68.914  -4.256  1.00 41.28           C  
ATOM    979  CG  LEU A 326       9.581  68.456  -2.801  1.00 41.11           C  
ATOM    980  CD1 LEU A 326       8.998  69.534  -1.893  1.00 41.39           C  
ATOM    981  CD2 LEU A 326       8.830  67.170  -2.636  1.00 41.09           C  
ATOM    982  N   GLN A 327       9.190  68.342  -7.616  1.00 44.08           N  
ATOM    983  CA  GLN A 327       9.038  69.107  -8.838  1.00 45.85           C  
ATOM    984  C   GLN A 327       7.898  70.076  -8.567  1.00 45.32           C  
ATOM    985  O   GLN A 327       6.862  69.677  -8.051  1.00 46.33           O  
ATOM    986  CB  GLN A 327       8.695  68.221 -10.027  1.00 47.64           C  
ATOM    987  CG  GLN A 327       8.337  69.047 -11.253  1.00 50.70           C  
ATOM    988  CD  GLN A 327       8.192  68.222 -12.506  1.00 54.17           C  
ATOM    989  OE1 GLN A 327       8.015  68.773 -13.593  1.00 57.12           O  
ATOM    990  NE2 GLN A 327       8.265  66.894 -12.370  1.00 52.96           N  
ATOM    991  N   VAL A 328       8.079  71.340  -8.925  1.00 44.36           N  
ATOM    992  CA  VAL A 328       7.064  72.345  -8.656  1.00 43.86           C  
ATOM    993  C   VAL A 328       6.743  73.244  -9.839  1.00 45.62           C  
ATOM    994  O   VAL A 328       7.558  73.414 -10.737  1.00 46.36           O  
ATOM    995  CB  VAL A 328       7.518  73.225  -7.493  1.00 42.96           C  
ATOM    996  CG1 VAL A 328       7.680  72.376  -6.235  1.00 40.71           C  
ATOM    997  CG2 VAL A 328       8.848  73.897  -7.851  1.00 40.55           C  
ATOM    998  N   GLY A 329       5.554  73.834  -9.826  1.00 46.38           N  
ATOM    999  CA  GLY A 329       5.164  74.712 -10.909  1.00 51.88           C  
ATOM   1000  C   GLY A 329       4.736  73.964 -12.156  1.00 56.55           C  
ATOM   1001  O   GLY A 329       4.449  72.768 -12.092  1.00 56.38           O  
ATOM   1002  N   GLN A 330       4.682  74.668 -13.286  1.00 61.23           N  
ATOM   1003  CA  GLN A 330       4.289  74.066 -14.558  1.00 66.64           C  
ATOM   1004  C   GLN A 330       5.168  72.848 -14.832  1.00 69.50           C  
ATOM   1005  O   GLN A 330       6.392  72.930 -14.754  1.00 70.27           O  
ATOM   1006  CB  GLN A 330       4.456  75.075 -15.693  1.00 68.36           C  
ATOM   1007  CG  GLN A 330       3.925  76.461 -15.377  1.00 72.65           C  
ATOM   1008  CD  GLN A 330       4.248  77.487 -16.464  1.00 75.82           C  
ATOM   1009  OE1 GLN A 330       4.101  78.695 -16.252  1.00 76.04           O  
ATOM   1010  NE2 GLN A 330       4.683  77.008 -17.636  1.00 77.44           N  
ATOM   1011  N   GLU A 331       4.543  71.719 -15.148  1.00 72.38           N  
ATOM   1012  CA  GLU A 331       5.283  70.491 -15.423  1.00 74.94           C  
ATOM   1013  C   GLU A 331       6.397  70.797 -16.441  1.00 74.70           C  
ATOM   1014  O   GLU A 331       7.582  70.591 -16.164  1.00 73.57           O  
ATOM   1015  CB  GLU A 331       4.325  69.421 -15.979  1.00 78.19           C  
ATOM   1016  CG  GLU A 331       2.904  69.470 -15.369  1.00 82.81           C  
ATOM   1017  CD  GLU A 331       1.876  68.564 -16.088  1.00 85.45           C  
ATOM   1018  OE1 GLU A 331       1.809  68.583 -17.346  1.00 84.45           O  
ATOM   1019  OE2 GLU A 331       1.123  67.843 -15.382  1.00 85.89           O  
ATOM   1020  N   GLN A 332       6.000  71.301 -17.609  1.00 74.94           N  
ATOM   1021  CA  GLN A 332       6.935  71.649 -18.685  1.00 75.85           C  
ATOM   1022  C   GLN A 332       7.733  72.889 -18.302  1.00 74.22           C  
ATOM   1023  O   GLN A 332       7.573  73.944 -18.922  1.00 73.83           O  
ATOM   1024  CB  GLN A 332       6.174  71.959 -19.986  1.00 79.27           C  
ATOM   1025  CG  GLN A 332       5.298  70.835 -20.542  1.00 82.91           C  
ATOM   1026  CD  GLN A 332       4.201  71.349 -21.482  1.00 85.27           C  
ATOM   1027  OE1 GLN A 332       3.256  72.024 -21.050  1.00 85.52           O  
ATOM   1028  NE2 GLN A 332       4.326  71.032 -22.771  1.00 85.41           N  
ATOM   1029  N   LYS A 333       8.583  72.770 -17.286  1.00 71.94           N  
ATOM   1030  CA  LYS A 333       9.388  73.902 -16.838  1.00 68.34           C  
ATOM   1031  C   LYS A 333      10.580  73.402 -16.032  1.00 66.53           C  
ATOM   1032  O   LYS A 333      11.543  74.128 -15.789  1.00 66.36           O  
ATOM   1033  CB  LYS A 333       8.531  74.854 -16.006  1.00 67.43           C  
ATOM   1034  CG  LYS A 333       8.967  76.290 -16.108  1.00 67.20           C  
ATOM   1035  CD  LYS A 333       8.004  77.212 -15.408  1.00 68.00           C  
ATOM   1036  CE  LYS A 333       8.408  78.659 -15.634  1.00 69.70           C  
ATOM   1037  NZ  LYS A 333       9.846  78.896 -15.299  1.00 71.65           N  
ATOM   1038  N   HIS A 334      10.490  72.149 -15.611  1.00 64.53           N  
ATOM   1039  CA  HIS A 334      11.560  71.489 -14.881  1.00 63.45           C  
ATOM   1040  C   HIS A 334      12.159  72.197 -13.676  1.00 60.82           C  
ATOM   1041  O   HIS A 334      13.373  72.401 -13.621  1.00 60.23           O  
ATOM   1042  CB  HIS A 334      12.676  71.139 -15.862  1.00 66.26           C  
ATOM   1043  CG  HIS A 334      12.194  70.389 -17.066  1.00 70.94           C  
ATOM   1044  ND1 HIS A 334      11.535  69.179 -16.975  1.00 71.97           N  
ATOM   1045  CD2 HIS A 334      12.249  70.690 -18.385  1.00 72.03           C  
ATOM   1046  CE1 HIS A 334      11.206  68.768 -18.186  1.00 72.25           C  
ATOM   1047  NE2 HIS A 334      11.627  69.666 -19.060  1.00 73.42           N  
ATOM   1048  N   THR A 335      11.317  72.555 -12.706  1.00 56.92           N  
ATOM   1049  CA  THR A 335      11.800  73.206 -11.494  1.00 51.36           C  
ATOM   1050  C   THR A 335      11.859  72.148 -10.417  1.00 50.58           C  
ATOM   1051  O   THR A 335      10.830  71.626 -10.000  1.00 49.76           O  
ATOM   1052  CB  THR A 335      10.864  74.314 -11.033  1.00 49.92           C  
ATOM   1053  OG1 THR A 335      10.621  75.214 -12.117  1.00 48.55           O  
ATOM   1054  CG2 THR A 335      11.487  75.077  -9.878  1.00 47.64           C  
ATOM   1055  N   TYR A 336      13.068  71.823  -9.973  1.00 50.71           N  
ATOM   1056  CA  TYR A 336      13.253  70.803  -8.948  1.00 51.57           C  
ATOM   1057  C   TYR A 336      13.805  71.429  -7.688  1.00 50.91           C  
ATOM   1058  O   TYR A 336      14.734  72.222  -7.741  1.00 51.99           O  
ATOM   1059  CB  TYR A 336      14.197  69.703  -9.449  1.00 53.58           C  
ATOM   1060  CG  TYR A 336      13.791  69.134 -10.793  1.00 56.14           C  
ATOM   1061  CD1 TYR A 336      14.441  69.529 -11.960  1.00 57.48           C  
ATOM   1062  CD2 TYR A 336      12.721  68.245 -10.906  1.00 57.07           C  
ATOM   1063  CE1 TYR A 336      14.042  69.062 -13.211  1.00 57.50           C  
ATOM   1064  CE2 TYR A 336      12.311  67.771 -12.156  1.00 59.21           C  
ATOM   1065  CZ  TYR A 336      12.982  68.186 -13.307  1.00 58.82           C  
ATOM   1066  OH  TYR A 336      12.601  67.718 -14.549  1.00 58.74           O  
ATOM   1067  N   LEU A 337      13.225  71.071  -6.551  1.00 49.97           N  
ATOM   1068  CA  LEU A 337      13.643  71.623  -5.276  1.00 47.91           C  
ATOM   1069  C   LEU A 337      14.065  70.539  -4.325  1.00 47.26           C  
ATOM   1070  O   LEU A 337      13.314  69.598  -4.074  1.00 49.00           O  
ATOM   1071  CB  LEU A 337      12.495  72.411  -4.643  1.00 46.43           C  
ATOM   1072  CG  LEU A 337      12.372  73.913  -4.893  1.00 47.46           C  
ATOM   1073  CD1 LEU A 337      12.947  74.284  -6.241  1.00 46.33           C  
ATOM   1074  CD2 LEU A 337      10.900  74.320  -4.777  1.00 47.01           C  
ATOM   1075  N   PRO A 338      15.278  70.647  -3.780  1.00 46.20           N  
ATOM   1076  CA  PRO A 338      15.738  69.622  -2.836  1.00 45.34           C  
ATOM   1077  C   PRO A 338      14.806  69.682  -1.635  1.00 43.68           C  
ATOM   1078  O   PRO A 338      14.296  70.743  -1.312  1.00 44.57           O  
ATOM   1079  CB  PRO A 338      17.154  70.084  -2.485  1.00 46.04           C  
ATOM   1080  CG  PRO A 338      17.585  70.843  -3.716  1.00 47.33           C  
ATOM   1081  CD  PRO A 338      16.346  71.607  -4.104  1.00 45.28           C  
ATOM   1082  N   LEU A 339      14.574  68.564  -0.968  1.00 42.79           N  
ATOM   1083  CA  LEU A 339      13.692  68.592   0.187  1.00 43.45           C  
ATOM   1084  C   LEU A 339      14.214  69.515   1.286  1.00 45.34           C  
ATOM   1085  O   LEU A 339      13.437  70.207   1.959  1.00 45.06           O  
ATOM   1086  CB  LEU A 339      13.523  67.194   0.767  1.00 40.14           C  
ATOM   1087  CG  LEU A 339      13.135  66.096  -0.205  1.00 39.07           C  
ATOM   1088  CD1 LEU A 339      12.846  64.862   0.621  1.00 38.20           C  
ATOM   1089  CD2 LEU A 339      11.932  66.495  -1.040  1.00 36.94           C  
ATOM   1090  N   GLU A 340      15.531  69.503   1.473  1.00 47.01           N  
ATOM   1091  CA  GLU A 340      16.192  70.319   2.496  1.00 47.94           C  
ATOM   1092  C   GLU A 340      15.707  71.731   2.618  1.00 45.79           C  
ATOM   1093  O   GLU A 340      15.399  72.179   3.712  1.00 47.50           O  
ATOM   1094  CB  GLU A 340      17.682  70.404   2.235  1.00 50.33           C  
ATOM   1095  CG  GLU A 340      18.460  69.336   2.885  1.00 52.99           C  
ATOM   1096  CD  GLU A 340      19.684  69.056   2.112  1.00 56.09           C  
ATOM   1097  OE1 GLU A 340      20.527  69.980   1.977  1.00 57.61           O  
ATOM   1098  OE2 GLU A 340      19.782  67.911   1.626  1.00 57.69           O  
ATOM   1099  N   VAL A 341      15.670  72.422   1.486  1.00 43.60           N  
ATOM   1100  CA  VAL A 341      15.264  73.820   1.417  1.00 42.91           C  
ATOM   1101  C   VAL A 341      13.754  74.019   1.383  1.00 42.73           C  
ATOM   1102  O   VAL A 341      13.274  75.085   0.987  1.00 44.05           O  
ATOM   1103  CB  VAL A 341      15.864  74.488   0.157  1.00 42.38           C  
ATOM   1104  CG1 VAL A 341      17.350  74.172   0.053  1.00 43.06           C  
ATOM   1105  CG2 VAL A 341      15.159  73.993  -1.077  1.00 39.42           C  
ATOM   1106  N   CYS A 342      12.994  73.023   1.815  1.00 41.04           N  
ATOM   1107  CA  CYS A 342      11.559  73.167   1.748  1.00 40.27           C  
ATOM   1108  C   CYS A 342      10.754  73.021   3.015  1.00 41.53           C  
ATOM   1109  O   CYS A 342      10.935  72.092   3.793  1.00 41.86           O  
ATOM   1110  CB  CYS A 342      11.016  72.234   0.680  1.00 37.12           C  
ATOM   1111  SG  CYS A 342      11.448  72.802  -0.953  1.00 36.74           S  
ATOM   1112  N   ASN A 343       9.852  73.972   3.207  1.00 42.08           N  
ATOM   1113  CA  ASN A 343       8.979  73.972   4.355  1.00 44.15           C  
ATOM   1114  C   ASN A 343       7.549  73.905   3.848  1.00 44.39           C  
ATOM   1115  O   ASN A 343       7.210  74.517   2.834  1.00 44.24           O  
ATOM   1116  CB  ASN A 343       9.176  75.254   5.168  1.00 47.14           C  
ATOM   1117  CG  ASN A 343      10.324  75.156   6.150  1.00 49.64           C  
ATOM   1118  OD1 ASN A 343      11.459  74.896   5.773  1.00 52.00           O  
ATOM   1119  ND2 ASN A 343      10.028  75.359   7.426  1.00 53.19           N  
ATOM   1120  N   ILE A 344       6.710  73.143   4.532  1.00 44.44           N  
ATOM   1121  CA  ILE A 344       5.311  73.069   4.144  1.00 44.97           C  
ATOM   1122  C   ILE A 344       4.629  74.317   4.689  1.00 45.40           C  
ATOM   1123  O   ILE A 344       4.683  74.589   5.889  1.00 43.08           O  
ATOM   1124  CB  ILE A 344       4.621  71.808   4.710  1.00 43.91           C  
ATOM   1125  CG1 ILE A 344       5.040  70.594   3.880  1.00 43.25           C  
ATOM   1126  CG2 ILE A 344       3.100  71.978   4.691  1.00 42.24           C  
ATOM   1127  CD1 ILE A 344       4.543  69.302   4.411  1.00 43.18           C  
ATOM   1128  N   VAL A 345       4.014  75.078   3.786  1.00 47.29           N  
ATOM   1129  CA  VAL A 345       3.317  76.308   4.136  1.00 48.64           C  
ATOM   1130  C   VAL A 345       1.940  76.011   4.703  1.00 51.51           C  
ATOM   1131  O   VAL A 345       1.173  75.238   4.135  1.00 49.46           O  
ATOM   1132  CB  VAL A 345       3.140  77.213   2.909  1.00 47.39           C  
ATOM   1133  CG1 VAL A 345       2.249  78.397   3.264  1.00 45.11           C  
ATOM   1134  CG2 VAL A 345       4.496  77.678   2.406  1.00 45.52           C  
ATOM   1135  N   ALA A 346       1.630  76.640   5.828  1.00 56.75           N  
ATOM   1136  CA  ALA A 346       0.336  76.444   6.469  1.00 61.54           C  
ATOM   1137  C   ALA A 346      -0.687  77.440   5.913  1.00 63.89           C  
ATOM   1138  O   ALA A 346      -0.402  78.643   5.809  1.00 63.90           O  
ATOM   1139  CB  ALA A 346       0.473  76.613   7.979  1.00 60.76           C  
ATOM   1140  N   GLY A 347      -1.865  76.927   5.547  1.00 66.26           N  
ATOM   1141  CA  GLY A 347      -2.927  77.770   5.020  1.00 69.28           C  
ATOM   1142  C   GLY A 347      -3.419  78.716   6.101  1.00 71.60           C  
ATOM   1143  O   GLY A 347      -3.185  78.472   7.288  1.00 71.92           O  
ATOM   1144  N   GLN A 348      -4.101  79.792   5.721  1.00 72.89           N  
ATOM   1145  CA  GLN A 348      -4.567  80.733   6.734  1.00 74.66           C  
ATOM   1146  C   GLN A 348      -6.024  81.162   6.602  1.00 75.01           C  
ATOM   1147  O   GLN A 348      -6.319  82.354   6.658  1.00 75.84           O  
ATOM   1148  CB  GLN A 348      -3.674  81.976   6.736  1.00 74.72           C  
ATOM   1149  CG  GLN A 348      -2.201  81.672   6.535  1.00 75.86           C  
ATOM   1150  CD  GLN A 348      -1.313  82.857   6.853  1.00 76.54           C  
ATOM   1151  OE1 GLN A 348      -1.102  83.194   8.022  1.00 76.33           O  
ATOM   1152  NE2 GLN A 348      -0.791  83.503   5.812  1.00 75.88           N  
ATOM   1153  N   ARG A 349      -6.931  80.203   6.439  1.00 75.13           N  
ATOM   1154  CA  ARG A 349      -8.350  80.527   6.318  1.00 75.44           C  
ATOM   1155  C   ARG A 349      -8.846  81.330   7.525  1.00 76.19           C  
ATOM   1156  O   ARG A 349      -8.269  81.270   8.616  1.00 76.26           O  
ATOM   1157  CB  ARG A 349      -9.189  79.251   6.175  1.00 74.83           C  
ATOM   1158  CG  ARG A 349      -9.270  78.685   4.761  1.00 74.26           C  
ATOM   1159  CD  ARG A 349     -10.191  77.471   4.732  1.00 73.23           C  
ATOM   1160  NE  ARG A 349     -10.470  76.981   3.383  1.00 72.54           N  
ATOM   1161  CZ  ARG A 349      -9.555  76.507   2.541  1.00 72.14           C  
ATOM   1162  NH1 ARG A 349      -8.282  76.458   2.901  1.00 72.55           N  
ATOM   1163  NH2 ARG A 349      -9.916  76.075   1.339  1.00 70.78           N  
TER    1164      ARG A 349                                                      
HETATM 1165  O   HOH A 501       2.420  70.354   9.098  1.00 35.26           O  
HETATM 1166  O   HOH A 502      15.923  58.761  -2.398  1.00 47.91           O  
HETATM 1167  O   HOH A 503       8.325  72.073 -13.393  1.00 36.76           O  
HETATM 1168  O   HOH A 504       2.291  80.100  -5.770  1.00 45.69           O  
HETATM 1169  O   HOH A 505       5.560  58.733  12.509  1.00 45.50           O  
HETATM 1170  O   HOH A 506      13.710  78.739  -5.137  1.00 46.55           O  
HETATM 1171  O   HOH A 507      13.433  73.146   6.371  1.00 46.92           O  
HETATM 1172  O   HOH A 508       9.071  61.896  13.245  1.00 46.57           O  
HETATM 1173  O   HOH A 509       4.403  81.131   5.477  1.00 55.17           O  
HETATM 1174  O   HOH A 510      15.191  55.315   5.042  1.00 60.46           O  
HETATM 1175  O   HOH A 511      16.139  67.803 -19.698  1.00 49.53           O  
HETATM 1176  O   HOH A 512       0.104  73.319   2.063  1.00 45.02           O  
HETATM 1177  O   HOH A 513      16.692  53.508  15.009  1.00 47.12           O  
HETATM 1178  O   HOH A 514      -4.022  62.100   0.454  1.00 56.07           O  
HETATM 1179  O   HOH A 515      27.036  65.771   0.303  1.00 49.07           O  
CONECT  187  188                                                                
CONECT  188  187  189  191                                                      
CONECT  189  188  190  192                                                      
CONECT  190  189                                                                
CONECT  191  188                                                                
CONECT  192  189                                                                
CONECT  239  248                                                                
CONECT  248  239  249                                                           
CONECT  249  248  250  252                                                      
CONECT  250  249  251  256                                                      
CONECT  251  250                                                                
CONECT  252  249  253                                                           
CONECT  253  252  254                                                           
CONECT  254  253  255                                                           
CONECT  255  254                                                                
CONECT  256  250                                                                
CONECT  571  578                                                                
CONECT  578  571  579                                                           
CONECT  579  578  580  582                                                      
CONECT  580  579  581  586                                                      
CONECT  581  580                                                                
CONECT  582  579  583                                                           
CONECT  583  582  584                                                           
CONECT  584  583  585                                                           
CONECT  585  584                                                                
CONECT  586  580                                                                
MASTER      317    0    3    3    8    0    0    6 1177    2   26   13          
END

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Related entries of code: 1si3

Entries with 90% protein sequence similarity cutoff in PDBbind
PDB Code	Check Database	Protein Sequence Similarity
1si2	RCSB PDB PDBbind	149aa, >1SI2_2\|Chain... *
Complexes with the same small molecule ligand
PDB Code	Check Database	Ligand Name
1si2	RCSB PDB PDBbind	9-mer
3gib	RCSB PDB PDBbind	9-mer
3h15	RCSB PDB PDBbind	9-mer
3k5q	RCSB PDB PDBbind	9-mer
3k5y	RCSB PDB PDBbind	9-mer
3k5z	RCSB PDB PDBbind	9-mer
3k61	RCSB PDB PDBbind	9-mer
3k62	RCSB PDB PDBbind	9-mer
3k64	RCSB PDB PDBbind	9-mer
5yki	RCSB PDB PDBbind	9-mer
5zvb	RCSB PDB PDBbind	9-mer

Entry Information

PDB ID	1si3
Complex Type	Protein-Nucleic Acid
PDBbind Subset	general set
Protein Name	Eukaryotic translation initiation factor 2C 1
Ligand Name	9-mer
EC.Number	E.C.-.-.-.-
Resolution	2.6(Å)
Affinity (Kd/Ki/IC50)	Kd=2.18nM
Release Year	2004
Protein/NA Sequence	Check fasta file
Primary Reference	Nature. (2004) 429, pp. 318-322

Links to External Databases

RCSB PDB	The mother database
PDBsum	Enhanced annotations on PDB entries
Pubchem	Comprehensive collection of chemical and biological data
UniProtKB AC	UniProt accession number (AC): Q9UL18
Entrez Gene ID	NCBI Entrez Gene ID: 26523
ASD	Information of known allosteric effects of PDB entries

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