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Related entries of code: 5laz
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
1rv1RCSB PDB    PDBbind85aa, >1RV1_1|Chains... at 98%
1t4eRCSB PDB    PDBbind96aa, >1T4E_1|Chains... at 98%
2axiRCSB PDB    PDBbind115aa, >2AXI_1|Chain... at 95%
2gv2RCSB PDB    PDBbind110aa, >2GV2_1|Chain... at 99%
2lzgRCSB PDB    PDBbind125aa, >2LZG_1|Chain... at 100%
3jzkRCSB PDB    PDBbind96aa, >3JZK_1|Chain... at 98%
3lbkRCSB PDB    PDBbind95aa, >3LBK_1|Chain... at 97%
3lblRCSB PDB    PDBbind95aa, >3LBL_1|Chains... at 98%
3lnzRCSB PDB    PDBbind85aa, >3LNZ_1|Chains... at 100%
3tu1RCSB PDB    PDBbind108aa, >3TU1_1|Chain... at 100%
3vbgRCSB PDB    PDBbind85aa, >3VBG_1|Chains... at 98%
3vzvRCSB PDB    PDBbind87aa, >3VZV_1|Chains... at 96%
3w69RCSB PDB    PDBbind87aa, >3W69_1|Chains... at 96%
4dijRCSB PDB    PDBbind96aa, >4DIJ_1|Chains... at 97%
4ereRCSB PDB    PDBbind96aa, >4ERE_1|Chains... at 98%
4erfRCSB PDB    PDBbind96aa, >4ERF_1|Chains... at 98%
4hbmRCSB PDB    PDBbind120aa, >4HBM_1|Chains... at 100%
4hg7RCSB PDB    PDBbind97aa, >4HG7_1|Chain... at 93%
4jv7RCSB PDB    PDBbind96aa, >4JV7_1|Chain... at 97%
4jv9RCSB PDB    PDBbind96aa, >4JV9_1|Chain... at 97%
4jveRCSB PDB    PDBbind96aa, >4JVE_1|Chain... at 97%
4jwrRCSB PDB    PDBbind95aa, >4JWR_1|Chains... at 100%
4mdnRCSB PDB    PDBbind94aa, >4MDN_1|Chain... at 98%
4mdqRCSB PDB    PDBbind86aa, >4MDQ_1|Chain... at 100%
4oasRCSB PDB    PDBbind96aa, >4OAS_1|Chains... at 98%
4obaRCSB PDB    PDBbind96aa, >4OBA_1|Chains... at 98%
4occRCSB PDB    PDBbind96aa, >4OCC_1|Chains... at 98%
4odeRCSB PDB    PDBbind105aa, >4ODE_1|Chain... at 100%
4odfRCSB PDB    PDBbind105aa, >4ODF_1|Chain... at 100%
4ognRCSB PDB    PDBbind105aa, >4OGN_1|Chain... at 100%
4ogtRCSB PDB    PDBbind105aa, >4OGT_1|Chain... at 100%
4ogvRCSB PDB    PDBbind95aa, >4OGV_1|Chains... at 100%
4oq3RCSB PDB    PDBbind96aa, >4OQ3_1|Chains... at 97%
4qo4RCSB PDB    PDBbind96aa, >4QO4_1|Chain... at 98%
4qocRCSB PDB    PDBbind96aa, >4QOC_1|Chains... at 98%
4wt2RCSB PDB    PDBbind105aa, >4WT2_1|Chain... at 100%
4zfiRCSB PDB    PDBbind97aa, >4ZFI_1|Chains... at 98%
4zgkRCSB PDB    PDBbind98aa, >4ZGK_1|Chains... at 98%
4zycRCSB PDB    PDBbind96aa, >4ZYC_1|Chains... at 97%
4zyfRCSB PDB    PDBbind96aa, >4ZYF_1|Chain... at 98%
4zyiRCSB PDB    PDBbind96aa, >4ZYI_1|Chain... at 98%
5hmhRCSB PDB    PDBbind101aa, >5HMH_1|Chains... at 93%
5hmiRCSB PDB    PDBbind104aa, >5HMI_1|Chains... at 93%
5hmkRCSB PDB    PDBbind109aa, >5HMK_1|Chains... at 98%
5j7fRCSB PDB    PDBbind125aa, >5J7F_1|Chains... at 100%
5j7gRCSB PDB    PDBbind109aa, >5J7G_1|Chains... at 99%
5lavRCSB PDB    PDBbind93aa, >5LAV_1|Chain... at 100%
5lawRCSB PDB    PDBbind94aa, >5LAW_1|Chain... at 100%
5layRCSB PDB    PDBbind95aa, >5LAY_1|Chains... at 100%
5trfRCSB PDB    PDBbind109aa, >5TRF_1|Chains... at 100%
6ggnRCSB PDB    PDBbind96aa, >6GGN_1|Chain... at 98%
6i3sRCSB PDB    PDBbind94aa, >6I3S_1|Chain... at 100%
6q9oRCSB PDB    PDBbind96aa, >6Q9O_1|Chains... at 98%
6q9lRCSB PDB    PDBbind96aa, >6Q9L_1|Chains... at 98%
6q9hRCSB PDB    PDBbind96aa, >6Q9H_1|Chain... at 98%
6q96RCSB PDB    PDBbind96aa, >6Q96_1|Chains... at 98%
6im9RCSB PDB    PDBbind122aa, >6IM9_2|Chain... at 98%
5oaiRCSB PDB    PDBbind97aa, >5OAI_1|Chain... at 98%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
No complexes with the same small molecule ligand are found!
Entry Information
PDB ID5laz
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameE3 ubiquitin-protein ligase Mdm2
Ligand Name6ST
EC.Number E.C.6.3.2
Resolution 1.66(Å)
Affinity (Kd/Ki/IC50)IC50=4nM
Release Year2016
Protein/NA SequenceCheck fasta file
Primary Reference (2016) J. Med. Chem. Vol. 59: pp. 10147-10162
Ligand Properties
Formula C30H28Cl2FN3O3
Molecular Weight 568.466
Exact Mass 567.149
No. of atoms 67
No. of bonds 73
Polar Surface Area 87.45
LOGP Value 4.08      (Computed with XLOGP3)
6.79      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 3
No. of Hydrogen Bond Acceptors: 3
No. of Rotatable Bonds: 4
No. of Nitrogen and Oxygen Atoms: 6
No. of Rings: 7
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): Q00987  
Entrez Gene IDNCBI Entrez Gene ID: 4193  
ASDInformation of known allosteric effects of PDB entries
 
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