Browse entries in the PDBbind-CN Database

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Related entries of code: 6g3c
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
4fvqRCSB PDB    PDBbind289aa, >4FVQ_1|Chain... *
4fvrRCSB PDB    PDBbind289aa, >4FVR_1|Chain... at 99%
5uszRCSB PDB    PDBbind289aa, >5USZ_1|Chain... at 100%
5ut0RCSB PDB    PDBbind289aa, >5UT0_1|Chain... at 100%
5ut4RCSB PDB    PDBbind289aa, >5UT4_1|Chain... at 100%
5ut6RCSB PDB    PDBbind289aa, >5UT6_1|Chain... at 100%
5winRCSB PDB    PDBbind277aa, >5WIN_1|Chain... at 100%
5wikRCSB PDB    PDBbind277aa, >5WIK_1|Chain... at 100%
5wijRCSB PDB    PDBbind277aa, >5WIJ_1|Chain... at 100%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
No complexes with the same small molecule ligand are found!
Entry Information
PDB ID6g3c
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameTyrosine-protein kinase V617F
Ligand NameEKT
EC.Number E.C.2.7.10.2
Resolution 1.6(Å)
Affinity (Kd/Ki/IC50)IC50=123nM
Release Year2019
Protein/NA SequenceCheck fasta file
Primary Reference (2019) Acs Chem.Biol. Vol. 14: pp. 587-593
Ligand Properties
Formula C20H25F2N5O2
Molecular Weight 405.442
Exact Mass 405.198
No. of atoms 54
No. of bonds 56
Polar Surface Area 81.59
LOGP Value 3.82      (Computed with XLOGP3)
4.01      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 2
No. of Hydrogen Bond Acceptors: 4
No. of Rotatable Bonds: 6
No. of Nitrogen and Oxygen Atoms: 7
No. of Rings: 3
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): O60674  
Entrez Gene IDNCBI Entrez Gene ID: 3717  
ASDInformation of known allosteric effects of PDB entries
 
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