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Related entries of code: 5lvx
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
2nsxRCSB PDB    PDBbind497aa, >2NSX_1|Chains... at 100%
2v3dRCSB PDB    PDBbind505aa, >2V3D_1|Chains... *
2v3eRCSB PDB    PDBbind505aa, >2V3E_1|Chains... at 100%
2wcgRCSB PDB    PDBbind505aa, >2WCG_1|Chains... at 100%
2xwdRCSB PDB    PDBbind505aa, >2XWD_1|Chains... at 100%
2xweRCSB PDB    PDBbind505aa, >2XWE_1|Chains... at 100%
3rikRCSB PDB    PDBbind497aa, >3RIK_1|Chains... at 100%
3rilRCSB PDB    PDBbind497aa, >3RIL_1|Chains... at 100%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
No complexes with the same small molecule ligand are found!
Entry Information
PDB ID5lvx
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameGlucosylceramidase
Ligand Name7E4/79B
EC.Number E.C.3.2.1.45
Resolution 2.2(Å)
Affinity (Kd/Ki/IC50)IC50=56nM
Release Year2017
Protein/NA SequenceCheck fasta file
Primary Reference (2018) J. Am. Chem. Soc. Vol. 140: pp. 5914-5924
Ligand Properties
Formula C33H34N4O
Molecular Weight 502.649
Exact Mass 502.273
No. of atoms 72
No. of bonds 76
Polar Surface Area 67.77
LOGP Value 7.66      (Computed with XLOGP3)
7.02      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 1
No. of Hydrogen Bond Acceptors: 4
No. of Rotatable Bonds: 12
No. of Nitrogen and Oxygen Atoms: 5
No. of Rings: 5
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): P04062  
Entrez Gene IDNCBI Entrez Gene ID: 2629  
ASDInformation of known allosteric effects of PDB entries
 
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